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AUTISM: spectrum disorders (ASD) often remain undiagnosed until adulthood. The aim of this study is to report differential diagnoses (DDX) and comorbidities of adults without intellectual impairment suspected of having an ASD and to test the self-assessment questionnaire Autism Quotient (AQ) for its suitability for screening.; METHODS: DDX and comorbidities were recorded with standardized scales in an autism outpatient clinic in 106 individuals. The AQ was tested against the expert judgment of an interdisciplinary case conference using ROC analysis.; RESULTS: Affective disorders were common in both groups (48%); other DDX were phobias (33%) and personality disorders (22%). The AQ showed an AUC of 0,527 with sensitivity/specificity of 70%/35%.; CONCLUSIONS: Adults suspected of having autism are highly burdened by DDX and comorbidities. An interdisciplinary diagnostic procedure based on standardized scales is useful, whereas the AQ hardly differentiates between persons with and without ASD. Thieme. All rights reserved., Ziel Erfassung von Differenzialdiagnosen (DD) und Komorbiditäten bei Erwachsenen mit Autismusverdacht, Überprüfung des Autismus Quotient (AQ) auf seine Eignung für das Screening. Methode Stichprobe N=106; ROC-Analyse des AQ gegen das klinische Expertenurteil. Ergebnisse Komorbide affektive Störungen in beiden Gruppen (48%), DD waren Angst- (33%) und Persönlichkeitsstörungen (22%). AQ: AUC=0,527, Sensitivität/Spezifität von 70%/35%. Schlussfolgerungen Erwachsene mit Autismusverdacht sind durch DD und Komorbiditäten hoch belastet. Der AQ ist für das Screening nicht geeignet.

Background Assessment of age-associated disorders has become increasingly important. Methods In a clinical setting, people with intellectual disability with and without dementia were assessed retrospectively using the Neuropsychological Test Battery (NTB) and the Dementia Questionnaire for People with Learning Disabilities (DLD) at two different times to analyse neuropsychological changes and diagnostic validity. One group (n = 44) was assessed with both instruments, while the DLD was applied in 71 patients. Results In the NTB (n = 44), only patients with dementia (n = 26) showed a decline in the NTB total score and three subscales. Receiver operating characteristic analysis revealed a diagnostic sensitivity of .67, a specificity of .81, and an area under the curve (AUC) of .767. In the DLD group (n = 71), only those with dementia displayed a decrease in the cognitive and social scale; diagnostic sensitivity and specificity values were low (.61/.63) and the AUC was .704. Conclusions Neuropsychological assessment was sensitive to detect cognitive changes over time. Sensitivity values of both instruments suggest a reassessment at a later time point.

Symmetric ciphers are more efficient for bulk encryption than asymmetric ciphers, however there is a lack of published studies providing relevant metrics pertaining to bulk encryption with RSA in modern computing environments. As key escrow systems proposed against ransomware provide alternative routes for data restoration, ransomware developers will seek to deploy resistant cryptosystems. In this study, we examine the use of a popular asymmetric cipher (RSA) for bulk encryption. We provide metrics for both encryption time and ciphertext expansion while examining the impact of different encryption parameters such as key size and block size. In addition, we consider supplementing encryption with compression to combat both ciphertext expansion and encryption time. Our goal is to highlight the need for solutions against the ransomware that use externally generated asymmetric key pairs for bulk encryption.

In this article 4 complexes energy efficiency measures for different energy efficiency classes are chosen, it is defined the thermal heating costs of the building during the heating period, it is defined the cost and the payback period of energy efficiency measures. The conclusion about the feasibility of capital repair of buildings by increasing energy efficiency class from an economic point of view is made.

Modern software products for thermal calculations make possible to speed up the design process and to improve the energy efficiency of new and renovated buildings. This article provides a complex evaluation, comparison and analysis of the feasibility of using Russian and foreign programs in thermal calculations.