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1. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case–control study and epidemiological remarks

Author

Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Dallari B., Pesatori A.C., Riboldi L., Merletti F., Gangemi M., Stura A., Brentisci C., Gilardetti M., Benfatto L., Canessa P.A., Malacarne D., Mazzucco G., Campi M.G., Fedeli U., Bressan V., Gioffre F., Ballarin M.N., Chermaz C., D'agostin F., De Michieli P., Mangone L., Storchi C., Sala O., Badiali A.M., Cacciarini V., Giovannetti L., Martini A., Calisti R., Pascucci C., Stracci F., Masanotti G., Davoli M., Cavariani F., Ancona L., Annunziata A., Menegozzo S., Napolitano F., Pelullo C.P., Vimercati L., Cascone G., Frasca G., Giurdanella M.C., Martorana C., Nicita C., Rollo C.P., Spata E., Dardanoni G., Scondotto S., Nieddu V., Pergola M., Stecchi S., Marinaccio, Alessandro, Consonni, Dario, Mensi, Carolina, Mirabelli, Dario, Migliore, Enrica, Magnani, Corrado, Di Marzio, Davide, Gennaro, Valerio, Mazzoleni, Guido, Girardi, Paolo, Negro, Corrado, Romanelli, Antonio, Chellini, Elisabetta, Grappasonni, Iolanda, Madeo, Gabriella, Romeo, Elisa, Ascoli, Valeria, Carrozza, Francesco, Angelillo, Italo Francesco, Cavone, Domenica, Tumino, Rosario, Melis, Massimo, Curti, Stefania, Brandi, Giovanni, Mattioli, Stefano, and Iavicoli, Sergio

Subjects
medicine.medical_specialty, pericardial and tunica vaginalis testis, Epidemiology, Population, rare disease, national registry, medicine.disease_cause, Epidemiology, Italy, National registry, Rare disease, Asbestos, epidemiology, Italy, national registry, rare disease, NO, 03 medical and health sciences, 0302 clinical medicine, italy, medicine, epidemiology, Italy, Mesothelioma, education, Gynecology, education.field_of_study, business.industry, Public Health, Environmental and Occupational Health, Tunica vaginalis testis, Case-control study, case–control study, Odds ratio, medicine.disease, asbestos, 030210 environmental & occupational health, National registry, exposure, mesothelioma, malignant mesothelioma, Original Article, Public aspects of medicine, RA1-1270, business, Rare disease
Abstract

Objectives: The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods: Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results: Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis mesothelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions: For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.

Published
2020

2. Characteristics and outcomes of pregnant women with placenta accreta spectrum in Italy: A prospective population-based cohort study

Author

Ornaghi, S, Maraschini, A, Donati, S, D'Aloja, P, Lega, I, Basevi, V, Cali, G, Dardanoni, G, Dubini, V, Lupi, C, Martinelli, P, Mondo, L, Pezzella, M, Puglia, M, Rusciani, R, Spettoli, D, Voller, F, Ornaghi S., Maraschini A., Donati S., D'Aloja P., Lega I., Basevi V., Cali G., Dardanoni G., Dubini V., Lupi C., Martinelli P., Mondo L., Pezzella M., Puglia M., Rusciani R., Spettoli D., Voller F., Ornaghi, S, Maraschini, A, Donati, S, D'Aloja, P, Lega, I, Basevi, V, Cali, G, Dardanoni, G, Dubini, V, Lupi, C, Martinelli, P, Mondo, L, Pezzella, M, Puglia, M, Rusciani, R, Spettoli, D, Voller, F, Ornaghi S., Maraschini A., Donati S., D'Aloja P., Lega I., Basevi V., Cali G., Dardanoni G., Dubini V., Lupi C., Martinelli P., Mondo L., Pezzella M., Puglia M., Rusciani R., Spettoli D., and Voller F.

Abstract

Introduction Placenta accreta spectrum (PAS) is a rare but potentially life-threatening event due to massive hemorrhage. Placenta previa and previous cesarean section are major risk factors for PAS. Italy holds one of the highest rates of primary and repeated cesarean section in Europe; nonetheless, there is a paucity of high-quality Italian data on PAS. The aim of this paper was to estimate the prevalence of PAS in Italy and to evaluate its associated factors, ante- and intra-partum management, and perinatal outcomes. Also, since severe morbidity and mortality in Italy show a North-South gradient, we assessed and compared perinatal outcomes of women with PAS according to the geographical area of delivery. Material and methods This was a prospective population-based study using the Italian Obstetric Surveillance System (ItOSS) and including all women aged 15–50 years with a diagnosis of PAS between September 2014 and August 2016. Six Italian regions were involved in the study project, covering 49% of the national births. Cases were prospectively reported by a trained clinician for each participating maternity unit by electronic data collection forms. The background population comprised all women who delivered in the participating regions during the study period. Results A cohort of 384 women with PAS was identified from a source population of 458 995 maternities for a prevalence of 0.84/1000 (95% CI, 0.75–0.92). Antenatal suspicion was present in 50% of patients, who showed reduced rates of blood transfusion compared to unsuspected patients (65.6% versus 79.7%, P = 0.003). Analyses by geographical area showed higher rates of both concomitant placenta previa and prior CS (62.1% vs 28.7%, P<0.0001) and antenatal suspicion (61.7% vs 28.7%, P<0.0001) in women in Southern compared to Northern Italy. Also, these women had lower rates of hemorrhage ≥2000 mL (29.6% vs 51.2%, P<0.0001), blood transfusion (64.5% vs 87.5%, P = 0.001), and severe maternal morbidity (5.

Published
2021

3. Childbirth care among sars-cov-2 positive women in Italy

Author

Donati, S, Corsi, E, Salvatore, M, Maraschini, A, Bonassisa, S, Casucci, P, Cataneo, I, Cetin, I, D'Aloja, P, Dardanoni, G, De Ambrosi, E, Ferrazzi, E, Fieni, S, Franchi, M, Gargantini, G, Iurlaro, E, Leo, L, Liberati, M, Livio, S, Locci, M, Marozio, L, Martini, C, Maso, G, Mecacci, F, Meloni, A, Mignuoli, A, Patane, L, Pellegrini, E, Perotti, F, Perrone, E, Prefumo, F, Ramenghi, L, Rusciani, R, Savasi, V, Schettini, S, Simeone, D, Simeone, S, Spinillo, A, Steinkasserer, M, Tateo, S, Ternelli, G, Tironi, R, Trojano, V, Vergani, P, Zullino, S, Donati S., Corsi E., Salvatore M. A., Maraschini A., Bonassisa S., Casucci P., Cataneo I., Cetin I., D'aloja P., Dardanoni G., De Ambrosi E., Ferrazzi E., Fieni S., Franchi M. P., Gargantini G., Iurlaro E., Leo L., Liberati M., Livio S., Locci M., Marozio L., Martini C., Maso G., Mecacci F., Meloni A., Mignuoli A. D., Patane L., Pellegrini E., Perotti F., Perrone E., Prefumo F., Ramenghi L., Rusciani R., Savasi V., Schettini S. C. A., Simeone D., Simeone S., Spinillo A., Steinkasserer M., Tateo S., Ternelli G., Tironi R., Trojano V., Vergani P., Zullino S., Donati, S, Corsi, E, Salvatore, M, Maraschini, A, Bonassisa, S, Casucci, P, Cataneo, I, Cetin, I, D'Aloja, P, Dardanoni, G, De Ambrosi, E, Ferrazzi, E, Fieni, S, Franchi, M, Gargantini, G, Iurlaro, E, Leo, L, Liberati, M, Livio, S, Locci, M, Marozio, L, Martini, C, Maso, G, Mecacci, F, Meloni, A, Mignuoli, A, Patane, L, Pellegrini, E, Perotti, F, Perrone, E, Prefumo, F, Ramenghi, L, Rusciani, R, Savasi, V, Schettini, S, Simeone, D, Simeone, S, Spinillo, A, Steinkasserer, M, Tateo, S, Ternelli, G, Tironi, R, Trojano, V, Vergani, P, Zullino, S, Donati S., Corsi E., Salvatore M. A., Maraschini A., Bonassisa S., Casucci P., Cataneo I., Cetin I., D'aloja P., Dardanoni G., De Ambrosi E., Ferrazzi E., Fieni S., Franchi M. P., Gargantini G., Iurlaro E., Leo L., Liberati M., Livio S., Locci M., Marozio L., Martini C., Maso G., Mecacci F., Meloni A., Mignuoli A. D., Patane L., Pellegrini E., Perotti F., Perrone E., Prefumo F., Ramenghi L., Rusciani R., Savasi V., Schettini S. C. A., Simeone D., Simeone S., Spinillo A., Steinkasserer M., Tateo S., Ternelli G., Tironi R., Trojano V., Vergani P., and Zullino S.

Abstract

The new coronavirus emergency spread to Italy when little was known about the infection’s impact on mothers and newborns. This study aims to describe the extent to which clinical practice has protected childbirth physiology and preserved the mother–child bond during the first wave of the pandemic in Italy. A national population-based prospective cohort study was performed enrolling women with confirmed SARS-CoV-2 infection admitted for childbirth to any Italian hospital from 25 February to 31 July 2020. All cases were prospectively notified, and information on peripartum care (mother–newborn separation, skin-to-skin contact, breastfeeding, and rooming-in) and maternal and perinatal outcomes were collected in a structured form and entered in a web-based secure system. The paper describes a cohort of 525 SARS-CoV-2 positive women who gave birth. At hospital admission, 44.8% of the cohort was asymptomatic. At delivery, 51.9% of the mothers had a birth support person in the delivery room; the average caesarean section rate of 33.7% remained stable compared to the national figure. On average, 39.0% of mothers were separated from their newborns at birth, 26.6% practised skin-to-skin, 72.1% roomed in with their babies, and 79.6% of the infants received their mother’s milk. The infants separated and not separated from their SARS-CoV-2 positive mothers both had good outcomes. At the beginning of the pandemic, childbirth raised awareness and concern due to limited available evidence and led to “better safe than sorry” care choices. An improvement of the peripartum care indicators was observed over time.

Published
2021

4. Coronavirus and birth in Italy: Results of a national population-based cohort study

Author

Donati, S, Maraschini, A, Lega, I, D'Aloja, P, Sampaolo, L, Salvatore, M, Corsi, E, Alberico, S, Casucci, P, Cetin, I, Dardanoni, G, Doganiero, F, Franchi, M, Ferrazzi, E, Leo, L, Liberati, M, Locci, M, Martini, C, Mecacci, F, Meloni, A, Mignuoli, A, Mondo, L, Patane, L, Perrone, E, Prefumo, F, Ramenghi, L, Savasi, V, Schettini, S, Steinkasserer, M, Tateo, S, Trojano, V, Vergani, P, Donati S., Maraschini A., Lega I., D'Aloja P., Sampaolo L., Salvatore M. A., Corsi E., Alberico S., Casucci P., Cetin I., Dardanoni G., Doganiero F., Franchi M. P., Ferrazzi E., Leo L., Liberati M., Locci M., Martini C., Mecacci F., Meloni A., Mignuoli A. D., Mondo L., Patane L., Perrone E., Prefumo F., Ramenghi L., Savasi V., Schettini S., Steinkasserer M., Tateo S., Trojano V., Vergani P., Donati, S, Maraschini, A, Lega, I, D'Aloja, P, Sampaolo, L, Salvatore, M, Corsi, E, Alberico, S, Casucci, P, Cetin, I, Dardanoni, G, Doganiero, F, Franchi, M, Ferrazzi, E, Leo, L, Liberati, M, Locci, M, Martini, C, Mecacci, F, Meloni, A, Mignuoli, A, Mondo, L, Patane, L, Perrone, E, Prefumo, F, Ramenghi, L, Savasi, V, Schettini, S, Steinkasserer, M, Tateo, S, Trojano, V, Vergani, P, Donati S., Maraschini A., Lega I., D'Aloja P., Sampaolo L., Salvatore M. A., Corsi E., Alberico S., Casucci P., Cetin I., Dardanoni G., Doganiero F., Franchi M. P., Ferrazzi E., Leo L., Liberati M., Locci M., Martini C., Mecacci F., Meloni A., Mignuoli A. D., Mondo L., Patane L., Perrone E., Prefumo F., Ramenghi L., Savasi V., Schettini S., Steinkasserer M., Tateo S., Trojano V., and Vergani P.

Abstract

Introduction. The study was implemented to provide guidance to decision-makers and clinicians by describing hospital care offered to women who gave birth with confirmed SARS-CoV-2 infection. Materials and methods. National population‐based prospective cohort study involving all women with confirmed SARS-CoV-2 infection who gave birth between February 25 and April 22, 2020 in any Italian hospital. Results. The incidence rate of confirmed SARS-CoV-2 infection in women who gave birth was 2.1 per 1000 maternities at a national level and 6.9/1000 in the Lombardy Region. Overall one third of the women developed a pneumonia and 49.7% assumed at least one drug against SARS-CoV-2 infection. Caesarean rate was 32.9%, no mothers nor newborns died. Six percent of the infants tested positive for SARS-CoV-2 at birth. Conclusions. Clinical features and outcomes of COVID-19 in women who gave birth are similar to those described for the general population, most women developing mild to moderate illness.

Published
2020

5. Coronavirus and birth in Italy: Results of a national population-based cohort study

Author

Donati S., Maraschini A., Lega I., D'Aloja P., Sampaolo L., Salvatore M. A., Corsi E., Alberico S., Casucci P., Cetin I., Dardanoni G., Doganiero F., Franchi M. P., Ferrazzi E., Leo L., Liberati M., Locci M., Martini C., Mecacci F., Meloni A., Mignuoli A. D., Mondo L., Patane L., Perrone E., Prefumo F., Ramenghi L., Savasi V., Schettini S., Steinkasserer M., Tateo S., Trojano V., Vergani P., Donati, S, Maraschini, A, Lega, I, D'Aloja, P, Sampaolo, L, Salvatore, M, Corsi, E, Alberico, S, Casucci, P, Cetin, I, Dardanoni, G, Doganiero, F, Franchi, M, Ferrazzi, E, Leo, L, Liberati, M, Locci, M, Martini, C, Mecacci, F, Meloni, A, Mignuoli, A, Mondo, L, Patane, L, Perrone, E, Prefumo, F, Ramenghi, L, Savasi, V, Schettini, S, Steinkasserer, M, Tateo, S, Trojano, V, Vergani, P, Donati S., Maraschini A., Lega I., D'Aloja P., Sampaolo L., Salvatore M.A., Corsi E., Alberico S., Casucci P., Cetin I., Dardanoni G., Doganiero F., Franchi M.P., Ferrazzi E., Leo L., Liberati M., Locci M., Martini C., Mecacci F., Meloni A., Mignuoli A.D., Mondo L., Patane L., Perrone E., Prefumo F., Ramenghi L., Savasi V., Schettini S., Steinkasserer M., Tateo S., Trojano V., and Vergani P.

Subjects
Pediatrics, medicine.medical_treatment, Infectious Disease Transmission, medicine.disease_cause, Adrenal Cortex Hormone, Population based cohort, Pregnancy, Adrenal Cortex Hormones, Cohort studies, COVID-19, Pregnancy outcome, SARS-CoV-2, Adult, Cesarean Section, Coronavirus Infections, Emigrants and Immigrants, Female, Fetal Organ Maturity, Humans, Incidence, Infant, Newborn, Infectious Disease Transmission, Vertical, Italy, Lung, Pneumonia, Viral, Pregnancy Complications, Infectious, Pregnancy Outcome, Premature Birth, Procedures and Techniques Utilization, Prospective Studies, Stillbirth, Betacoronavirus, Pandemics, Vertical, Viral, Prospective cohort study, pregnancy, pregnancy outcome, cohort studies, Coronavirus, education.field_of_study, Infectious, Human, medicine.medical_specialty, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, NO, medicine, Caesarean section, National level, education, Betacoronaviru, Pandemic, business.industry, Coronavirus Infection, Infant, Emigrants and Immigrant, Pneumonia, medicine.disease, Newborn, COVID-19 Drug Treatment, Pregnancy Complications, Prospective Studie, Pregnancy Complications, Infectiou, business, Cohort studie
Abstract

IntroductionThe study was implemented to provide guidance to decision-makers and clinicians by describing hospital care offered to women who gave birth with confirmed COVID-19 infection.Materials and methodsNational population-based prospective cohort study involving all women with confirmed COVID-19 who gave birth between February 25 and April 22, 2020 in any Italian hospital.ResultsThe incidence rate of confirmed SARS-CoV-2 infection in women who gave birth was 2.1 per 1000 maternities at a national level and 6.9/1000 in the Lombardy Region. Overall one third of the women developed a pneumonia and 49.7% assumed at least one drug. Caesarean section rate was 32.9%, no mothers nor newborns died. Six percent of the infants tested positive for SARS – CoV-2 at birth.ConclusionsClinical features and outcomes of COVID-19 in women who gave birth are similar to those described for the general population, most women developing mild to moderate illness.

Published
2020

6. Malignant mesothelioma due to non-occupational asbestos exposure from the Italian national surveillance system (ReNaM): epidemiology and public health issues

Author

Marinaccio, Alessandro, Binazzi, Alessandra, Bonafede, Michela, Corfiati, Marisa, Di Marzio, Davide, Scarselli, Alberto, Verardo, Marina, Mirabelli, Dario, Gennaro, Valerio, Mensi, Carolina, Schallemberg, Gert, Merler, Enzo, Negro, Corrado, Romanelli, Antonio, Chellini, Elisabetta, Silvestri, Stefano, Cocchioni, Mario, Pascucci, Cristiana, Stracci, Fabrizio, Ascoli, Valeria, Trafficante, Luana, Angelillo, Italo, Musti, Marina, Cavone, Domenica, Cauzillo, Gabriella, Tallarigo, Federico, Tumino, Rosario, Melis, Massimo, Detragiache, E, Merletti, F, Gangemi, M, Stura, A, Brentisci, C, Cammarieri, Diglio G, Macerata, V, Gilardetti, M, Benfatto, L, Bianchelli, M, Mazzucco, G, Consonni, D, Pesatori, AC, Riboldi, L, Bressan, V, Gioffrè, F, Ballarin, MN, Chermaz, C, De Michieli, P, Mangone, L, Storchi, C, Sala, O, Badiali, AM, Cacciarini, V, Giovannetti, L, Martini, A, Calisti, R, La, Rosa F, DʼAlo’, D, Petrucci, MS, Davoli, M, Forastiere, F, Cavariani, F, Romeo, E, Ancona, L, Di Giammarco, A, Menegozzo, S, Canfora, ML, Santoro, M, Viscardi, F, Brangi, A, Cozza, V, Baldassarre, A, Lio, S, Nicita, C, Dardanoni, G, Scondotto, S, Nieddu, V, Pergola, M, and Stecchi, S

Published
2015
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10. Characteristics and outcomes of pregnant women with placenta accreta spectrum in Italy: A prospective population-based cohort study

Author

Ornaghi S., Maraschini A., Donati S., D'Aloja P., Lega I., Basevi V., Cali G., Dardanoni G., Dubini V., Lupi C., Martinelli P., Mondo L., Pezzella M., Puglia M., Rusciani R., Spettoli D., Voller F., Ornaghi, S, Maraschini, A, Donati, S, D'Aloja, P, Lega, I, Basevi, V, Cali, G, Dardanoni, G, Dubini, V, Lupi, C, Martinelli, P, Mondo, L, Pezzella, M, Puglia, M, Rusciani, R, Spettoli, D, and Voller, F

Subjects
Embryology, European People, Critical Care and Emergency Medicine, Blood transfusion, Epidemiology, Maternal Health, Placenta, medicine.medical_treatment, Placenta Previa, Vascular Medicine, Cohort Studies, Labor and Delivery, Pregnancy, Risk Factors, Medicine and Health Sciences, Prevalence, Ethnicities, Prospective Studies, education.field_of_study, Multidisciplinary, Obstetrics, Gynecologic Surgery, Obstetrics and Gynecology, placenta, cesarean, Hematology, Severe Blood Loss, Middle Aged, Clinical Laboratory Sciences, Italian People, Italy, Cohort, Medicine, Female, Electronic data, Anatomy, Research Article, Adult, medicine.medical_specialty, Adolescent, Referral, Placenta accreta, Science, Population, Surgical and Invasive Medical Procedures, Hemorrhage, Placenta Accreta, Hysterectomy, Young Adult, Signs and Symptoms, Diagnostic Medicine, medicine, Humans, Blood Transfusion, education, Transfusion Medicine, Cesarean Section, business.industry, Postpartum Hemorrhage, Reproductive System, Biology and Life Sciences, medicine.disease, Placenta previa, Health Care, Medical Risk Factors, Concomitant, People and Places, Birth, Women's Health, Population Groupings, Clinical Medicine, Health Statistics, Morbidity, business, Developmental Biology
Abstract

Introduction Placenta accreta spectrum (PAS) is a rare but potentially life-threatening event due to massive hemorrhage. Placenta previa and previous cesarean section are major risk factors for PAS. Italy holds one of the highest rates of primary and repeated cesarean section in Europe; nonetheless, there is a paucity of high-quality Italian data on PAS. The aim of this paper was to estimate the prevalence of PAS in Italy and to evaluate its associated factors, ante- and intra-partum management, and perinatal outcomes. Also, since severe morbidity and mortality in Italy show a North-South gradient, we assessed and compared perinatal outcomes of women with PAS according to the geographical area of delivery. Material and methods This was a prospective population-based study using the Italian Obstetric Surveillance System (ItOSS) and including all women aged 15–50 years with a diagnosis of PAS between September 2014 and August 2016. Six Italian regions were involved in the study project, covering 49% of the national births. Cases were prospectively reported by a trained clinician for each participating maternity unit by electronic data collection forms. The background population comprised all women who delivered in the participating regions during the study period. Results A cohort of 384 women with PAS was identified from a source population of 458 995 maternities for a prevalence of 0.84/1000 (95% CI, 0.75–0.92). Antenatal suspicion was present in 50% of patients, who showed reduced rates of blood transfusion compared to unsuspected patients (65.6% versus 79.7%, P = 0.003). Analyses by geographical area showed higher rates of both concomitant placenta previa and prior CS (62.1% vs 28.7%, PPPP = 0.001), and severe maternal morbidity (5.0% vs 11.1%, P = 0.036). Delivery in a referral center for PAS occurred in 71.9% of these patients. Conclusions Antenatal suspicion of PAS is associated with improved maternal outcomes, also among high-risk women with both placenta previa and prior CS, likely because of their referral to specialized centers for PAS management.

Published
2021

12. Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study

Author

Iacopetta, B., Russo, A., Bazan, V., Dardanoni, G., Gebbia, N., Soussi, T., Kerr, D., Elsaleh, H., Soong, R., Kandioler, D., Janschek, E., Kappel, S., Lung, M., Leung, C.-S.S., Ko, J.M., Yuen, S., Ho, J., Leung, S.Y., Crapez, E., Duffour, J., Ychou, M., Leahy, D.T., O'Donoghue, D.P., Agnese, V., Cascio, S., Di Fede, G., Chieco-Bianchi, L., Bertorelle, R., Belluco, C., Giaretti, W., Castagnola, P., Ricevuto, E., Ficorella, C., Bosari, S., Arizzi, C.D., Miyaki, M., Onda, M., Kampman, E., Diergaarde, B., Royds, J., Lothe, R.A., Diep, C.B., Meling, G.I., Ostrowski, J., Trzeciak, L., Guzińska-Ustymowicz, K., Zalewski, B., Capellá, G.M., Moreno, V., Peinado, M.A., Lönnroth, C., Lundholm, K., Sun, X.F., Jansson, A., Bouzourene, H., Hsieh, L.-L., Tang, R., Smith, D.R., Allen-Mersh, T.G., Khan, Z.A.J., Shorthouse, A.J., Silverman, M.L., Kato, S., and Ishioka, C.

Published
2006
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13. Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dellʼItalia Meridionale) prospective study

Author

Bazan, V., Bruno, L., Augello, C., Agnese, V., Calò, V., Corsale, S., Gargano, G., Terrasi, M., Schirò, V., Fede, G. Di, Adamo, V., Intrivici, C., Crosta, A., Rinaldi, G., Latteri, F., Dardanoni, G., Grassi, N., Valerio, M. R., Colucci, G., Macaluso, M., and Russo, A.

Published
2006

18. The epidemiology of malignant mesothelioma in women: gender differences and modalities of asbestos exposure

Author

Marinaccio, Alessandro, Corfiati, Marisa, Binazzi, Alessandra, Di Marzio, Davide, Scarselli, Alberto, Ferrante, Pierpaolo, Bonafede, Michela, Verardo, Marina, Mirabelli, Dario, Gennaro, Valerio, Mensi, Carolina, Schallemberg, Gert, Mazzoleni, Guido, Merler, Enzo, Girardi, Paolo, Negro, Corrado, D'Agostin, Flavia, Romanelli, Antonio, Chellini, Elisabetta, Silvestri, Stefano, Pascucci, Cristiana, Calisti, Roberto, Stracci, Fabrizio, Romeo, Elisa, Ascoli, Valeria, Trafficante, Luana, Carrozza, Francesco, Angelillo, Italo Francesco, Cavone, Domenica, Cauzillo, Gabriella, Tallarigo, Federico, Tumino, Rosario, Melis, Massimo, Iavicoli, Sergio, Detragiache, E, Merletti, F, Gangemi, M, Stura, A, Brentisci, C, Diglio, Gc, Macerata, V, Gilardetti, M, Lazzarotto, A, Benfatto, L, Bianchelli, M, Mazzucco, G, Campi, M, Malacarne, D, Camposeragno, D, Giorgio, Fd, Canessa, P, Consonni, D, Pesatori, A, Riboldi, L, Bressan, V, Gioffrè, F, Ballarinl, M, Chermaz, C, Michieli, P, Mangone, L, Storchi, C, Sala, O, Badiali, A, Cacciarini, V, Giovannetti, L, Martini, A, Grappasonni, I, Masanotti, G, D'Alo', D, Petrucci, M, Davoli, M, Forastiere, F, Cavariani, F, Ancona, L, Giammarco, Ad, Menegozzo, S, Canfora, M, Santoro, M, Viscardi, F, Brangi, A, Cozza, V, Vimercati, L, Lio, S, Cascone, G, Frasca, G, Giurdanella, M, Martorana, C, Nicita, C, Rollo, P, Spata, E, Dardanoni, G, Scondotto, S, Nieddu, V, Pergola, M, Stecchi, S., Marinaccio, A, Corfiati, M, Binazzi, A, Di Marzio, D, Scarselli, A, Ferrante, P, Bonafede, M, Verardo, M, Mirabelli, D, Gennaro, V, Mensi, C, Schallemberg, G, Mazzoleni, G, Merler, E, Girardi, P, Negro, C, D'Agostin, F, Romanelli, A, Chellini, E, Silvestri, S, Pascucci, C, Calisti, R, Stracci, F, Romeo, E, Ascoli, V, Trafficante, L, Carrozza, F, Angelillo, If, Cavone, D, Cauzillo, G, Tallarigo, F, Tumino, R, Melis, M, Iavicoli, S., Marinaccio, Alessandro, Corfiati, Marisa, Binazzi, Alessandra, Di Marzio, Davide, Scarselli, Alberto, Ferrante, Pierpaolo, Bonafede, Michela, Verardo, Marina, Mirabelli, Dario, Gennaro, Valerio, Mensi, Carolina, Schallemberg, Gert, Mazzoleni, Guido, Merler, Enzo, Girardi, Paolo, Negro, Corrado, D'Agostin, Flavia, Romanelli, Antonio, Chellini, Elisabetta, Silvestri, Stefano, Pascucci, Cristiana, Calisti, Roberto, Stracci, Fabrizio, Romeo, Elisa, Ascoli, Valeria, Trafficante, Luana, Carrozza, Francesco, Angelillo, Italo Francesco, Cavone, Domenica, Cauzillo, Gabriella, Tallarigo, Federico, Tumino, Rosario, Melis, Massimo, and Iavicoli, Sergio

Subjects
medicine.medical_specialty, asbestos, gender, mesothelioma, asbestos, gender, mesothelioma, medicine.disease_cause, Asbestos, asbesto, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, Medicine, 030212 general & internal medicine, Mesothelioma, Workplace, Modalities, business.industry, Incidence (epidemiology), Mortality rate, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, medicine.disease, 030220 oncology & carcinogenesis, Workforce, Etiology, Public Health, Settore SECS-S/01 - Statistica, business, Demography
Abstract

IntroductionThe epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register.MethodsIncident malignant mesothelioma (MM) cases in the period 1993 to 2012 were retrieved from ReNaM. Gender ratio by age class, period of diagnosis, diagnostic certainty, morphology and modalities of asbestos exposure has been analysed using exact tests for proportion. Economic activity sectors, jobs and territorial distribution of mesothelioma cases in women have been described and discussed. To perform international comparative analyses, the gender ratio of mesothelioma deaths was calculated by country from the WHO database and the correlation with the mortality rates estimated.ResultsIn the period of study a case list of 21 463 MMs has been registered and the modalities of asbestos exposure have been investigated for 16 458 (76.7%) of them. The gender ratio (F/M) was 0.38 and 0.70 (0.14 and 0.30 for occupationally exposed subjects only) for pleural and peritoneal cases respectively. Occupational exposures for female MM cases occurred in the chemical and plastic industry, and mainly in the non-asbestos textile sector. Gender ratio proved to be inversely correlated with mortality rate among countries.ConclusionsThe consistent proportion of mesothelioma cases in women in Italy is mainly due to the relevant role of non-occupational asbestos exposures and the historical presence of the female workforce in several industrial settings. Enhancing the awareness of mesothelioma aetiology in women could support the effectiveness of welfare system and prevention policies.

Published
2018

19. Epidemiology of preeclampsia in a Sicilian Hospital

Author

Pandolfo, MC, Catania, M, Dardanoni, G, Rinoldo, C, Bertolazzi, G, Ferrara, C, Palumbo, E, D'Anna, MR, Pandolfo, MC, Catania, M, Dardanoni, G, Rinoldo, C, Bertolazzi, G, Ferrara, C, Palumbo, E, and D'Anna, MR

Subjects
Preeclampsia, epidemiology, Sicily, twin pregnancy
Abstract

Multivariate logistic regression has shown that the following variables are independent risk factors for preeclampsia: age, BMI, parity, and twin pregnancy. Moreover, preeclampsia is significantly associated with the examined clinical effects, confirming itself as a leading cause of maternal-fetal morbidity.

Published
2016

21. Stili di vita e salute dei giovani in età scolare: rapporto sui dati della regione sicilia HBSC (Health behaviour in school-aged children - comportamenti collegati alla salute dei ragazzi di età scolare) 2009-2010

Author

MARSALA, Maria Grazia Laura, MORICI, Mariagrazia, SIDOTI, Enza, FIRENZE, Alberto, VITALE, Francesco, Scondotto, S, Cernigliaro, A, Dardanoni, G, Marsala, M, Morici, M, Scondotto, S, Sidoti, E, Cernigliaro, A, Dardanoni, G, Firenze, A, and Vitale, F

Subjects
HBSC, Stili di Vita, Giovani
Published
2012

22. Sorveglianza della mortalità infantile nella provincia di Palermo. Dati prelminari

Author

Mazzucco, W., Cusimano, R., LA SCOLA, C., Sammarco, S., Casuccio, N., Pitarresi, A., Scondotto, S., Dardanoni, G., Cassata, N., Corsello, G., Vitale, F., MAZZUCCO W, CUSIMANO R, LA SCOLA C, SAMMARCO S, CASUCCIO N, PITARRESI A, SCONDOTTO S, DARDANONI G, CASSATA N, CORSELLO G, and VITALE F

Subjects
mortalità infantile, sorveglianza, cause di morte, Settore MED/42 - Igiene Generale E Applicata
Published
2007

23. Variabili cliniche nella casistica del policlinico di Palermo nell’ambito del registro dei tumori della tiroide in Sicilia: Età, sesso, autoimmunità, tipo, dimensionilesionali e coinvolgimento delle stazioni linfonodali della tiroide

Author

RICHIUSA P, DARDANONI G, RUSSO L, SCIARRINO G, GRACEFFA G, LI VOLSI F, MODICA G, ROMANO M, GIORDANO, Carla, SMERALDI, Lucia, NUCERA, Miriam, FORTI, Domenica, PIZZOLANTI, Giuseppe, AMATO, Marco Calogero, GULOTTA, Gaspare, LATTERI, Mario, RICHIUSA P, DARDANONI G, RUSSO L, SMERALDI L, NUCERA M, FORTI D, PIZZOLANTI G, AMATO MC, SCIARRINO G, GRACEFFA G, LI VOLSI F, GULOTTA G, LATTERI M, MODICA G, ROMANO M, and GIORDANO C

Published
2007

24. Sorveglianza della mortalità infantile nella Provincia di Palermo

Author

Cusimano, R., Mazzucco, W., LA SCOLA, C., Sammarco, S., Casuccio, N., Pitarresi, A., Scondotto, S., Dardanoni, G., Cassata, N., Corsello, G., Vitale, F., CUSIMANO R, MAZZUCCO W, LA SCOLA C, SAMMARCO S, CASUCCIO N, PITARRESI A, SCONDOTTO S, DARDANONI G, CASSATA N, CORSELLO G, and VITALE F

Subjects
registri tumori, mortalità infantile, sorveglianza
Published
2006

25. A case-control study on risk factors for nuclear, cortical and posterior subcapsular cataract: The Casteldaccia Eye Study

Author

GIUFFRE', Giuseppe, DARDANONI G, LODATO, Gaetano, GIUFFRE' G, DARDANONI G, and LODATO G

Subjects
risk factor, cataract, case-control study, epidemiology, iris atrophy
Abstract

Purpose: To investigate risk factors for nuclear, cortical and posterior subcapsular age-related cataract. Methods: A case-control study was carried out on subjects aged 40 years and older, living in Casteldaccia, Sicily. Twenty-seven potential risk factors were investigated. Nuclear, cortical and posterior subcapsular opacities of the lens were classified according to the Lens Opacities Classification System II. Subjects with advanced lens opacities represented the cases, while an identical number of subjects without or with early cataract, matched for sex and age, were recruited as controls from within the same population. Results: Univariate analysis showed that myopia and iris atrophy were significantly associated with nuclear cataract. Iris atrophy, use of corticosteroids, pseudoexfoliation syndrome and familial occurrence of cataract were positively correlated with cortical cataract. Myopia, iris atrophy, use of corticosteroids and familial occurrence of cataract presented an association with posterior subcapsular cataract. After multivariate analysis, the variables that remained significantly associated were myopia and iris atrophy for nuclear cataract; iris atrophy, pseudoexfoliation syndrome and familial occurrence of cataract for cortical cataract; and myopia, iris atrophy and familial occurrence of cataract for posterior subcapsular cataract. Conclusion: In addition to well known risk factors such as myopia or use of corticosteroids, the Casteldaccia case-control study shows that iris atrophy represents a previously unrecognized risk factor for each of the three types of cataract.

Published
2005

30. [Epidemiologic surveillance of mesothelioma for the prevention of asbestos exposure also in non-traditional settings]

Author

Binazzi, A., Scarselli, A., Corfiati, M., Di Marzio, D., Branchi, C., Verardo, M., Mirabelli, D., Gennaro, V., Mensi, C., Schallenberg, G., Merler, E., De Zotti, R., Romanelli, A., Chellini, E., Pascucci, C., D'Alo, D., Forastiere, F., Trafficante, L., Menegozzo, S., Musti, M., Cauzillo, G., Leotta, A., Tumino, R., Melis, M., Marinaccio, A., Gruppo Di, Lavoro Renam Detragiache E., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Diglio, Cammarieri G., Macerata, V., Gilardetti, M., Benfatto, L., Bianchelli, M., Mazzucco, G., Sieno, C., Pesatori, A., Riboldi, L., Gioffre, F., Bressan, V., De Michieli, P., Chermaz, C., Negro, C., Mangone, L., Storchi, C., Silvestri, S., Badiali, A., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., La Rosa, F., Stracci, F., Cavariani, F., Ascoli, Valeria, Romeo, E., Sangalli, M., Gatta, S., Izzo, F., Canfora, M., Santoro, M., Viscardi, F., Cavone, D., Massaro, T., Convertini, L., Giovanni, L., Nicita, C., Nieddu, V., Pergola, M., Stecchi, S., Dardanoni, G., and Scondotto, S.

Subjects
Male, Mesothelioma, Lung Neoplasms, asbestos, epidemiologic surveillance, prevention, mesothelioma, Pleural Neoplasms, Mesothelioma, Malignant, Asbestos, Middle Aged, Occupational Diseases, Italy, Occupational Exposure, Population Surveillance, Epidemiological Monitoring, Humans, Female, Registries
Abstract

To show how malignant mesothelioma (MM) surveillance not only identifies settings of exposure representing past industrial history, but it may also detect conditions of current exposure relevant for the prevention, if the wide spectrum of asbestos uses is considered.Active search of MM cases and exposure assessment at individual level through a questionnaire; identification of exposure circumstances relevant for prevention.Italy, all the Regions where a Regional Operating Centre (COR) is established to identify all MM cases diagnosed in the population and analyze their occupational, residential, household and environmental histories. Period of diagnosis: 1993-2008.Descriptive analysis of MM cases and of asbestos exposures.ReNaM includes 15,845 cases of MM diagnosed between 1993 and 2008.The male/female ratio is 2.5. Mean age at diagnosis is 69 years. Pleural MMs represent 93% of all cases. Exposures have been investigated in 12,065 cases (76%). The median latency time is 46 years. In addition to clusters of MM cases in activities well known to entail asbestos use, different current exposure circumstances requiring intervention have been evidenced.On the basis of this experience, epidemiological surveillance of all occupational cancers should be implemented to foster synergies with the compensation system and the Local Health Authorities' occupational safety and health services, as required by the Italian Legislative Decree N. 81/2008.

Published
2013

31. Late presenters among persons with a new HIV diagnosis in Italy, 2010–2011

Author

Camoni, L., Raimondo, M., Regine, V., Salfa, M. C., Suligoi, B., Carboni, A, Cassiani, R, Chironna, M, Dardanoni, G, Finarelli, Ac, Gallo, L, Icardi, G, Locuratolo, F, Mura, Ms, Palombino, R, Gramegna, M, Pasqualini, C, Pristerà, R, Pozza, F, Rossetti, G, Scola, N, Sudano, L, Tosti, A, Voller, F, and Zaccone, A.

Subjects
Adult, Male, Gerontology, medicine.medical_specialty, Delayed Diagnosis, Epidemiology, Sexual Behavior, HIV diagnosis, Human immunodeficiency virus (HIV), Emigrants and Immigrants, HIV Infections, Disease, medicine.disease_cause, Statistics, Nonparametric, Risk-Taking, Acquired immunodeficiency syndrome (AIDS), Internal medicine, medicine, Late presenters, Humans, Nonparametric, Substance Abuse, Intravenous, Surveillance, business.industry, Public health, Statistics, Substance Abuse, Public Health, Environmental and Occupational Health, HIV, Middle Aged, medicine.disease, CD4 Lymphocyte Count, Sexual Partners, Italy, Population Surveillance, Female, Biostatistics, Intravenous, business, Research Article
Abstract

Background In Western Europe, about 50% of newly diagnosed HIV-positive individuals are diagnosed at a late stage disease and enter in care late (i.e. with a CD4 count ≤350 μL/μL). The aim of the present study is to analyze the characteristics and the factors associated with being diagnosed late or at an advanced stage of disease among persons with a new HIV diagnosis in Italy, in the period 2010–2011. Methods We used individual data on new HIV diagnoses reported by the HIV surveillance system in 2010 and in 2011. Persons with CD4 ≤350 cells/μL or diagnosed with AIDS (regardless of the CD4 cell count) were defined as late presenters (LP); persons with CD4 ≤ 200 cells/μL or AIDS (regardless of the CD4 cell count) were defined as presenting with advanced HIV disease (AHD). Results Of the 7,300 new diagnoses reported in 2010–2011 by the included regions, 55.2% were LP; among these, 37.9% was diagnosed with AIDS. Persons presenting with AHD were 37.8%. The median age of LP was 40 years (IQR 33–48), significantly higher (p

Published
2013

32. p53 mutations in L3-loop zinc-binding domain, DNA-ploidy, and S phase fraction are independent prognostic indicators in colorectal cancer: A prospective study with a five-year follow-up

Author

Russo, A., Migliavacca, M., Zanna, I., Valerio, M. R., Latteri, M. A., Grassi, N., Pantuso, G., Sergio Salerno, Dardanoni, G., Albanese, I., La Farina, M., Tomasino, R. M., Gebbia, N., Bazan, V., Russo, A, Migliavacca, M, Zanna, I, Valerio, MR, Latteri, MA, Grassi, N, Pantuso, G, Salerno, S, Dardanoni, G, Albanese, I, La Farina, M, Tomasino, RM, Gebbia, N, and Bazan, V

Subjects
Male, Settore MED/06 - Oncologia Medica, protein p53, S Phase, Biomarkers, Tumor, Humans, Prospective Studies, Codon, Aged, Ploidies, Polymorphism, Genetic, DNA, Neoplasm, Exons, DNA, Middle Aged, Genes, p53, Prognosis, Survival Analysis, Protein Structure, Tertiary, Italy, Multivariate Analysis, Mutation, Female, Carrier Proteins, Colorectal Neoplasms, Follow-Up Studies
Abstract

p53 gene alterations are among the most common events observed in colorectal cancer,and are accompanied frequently by DNA aneuploidy and high proliferative activity. The prognostic significance of such mutations remains controversial. We prospectively evaluated the prognostic significance of p53 mutations, DNA-ploidy, and S phase fraction (SPF) in a consecutive series of 160 colorectal cancer patients (median follow-up 71 months). Tumor DNA was screened for p53 mutations by PCR/single-strand conformational polymorphism/sequencing. DNA-ploidy and SPF were assessed by DNA flow cytometry. p53 mutations were detected in 68 of 160 (42.5%) cases. In 56% (38 of 68) of these, p53 mutations were found in conserved areas of the gene and in 44% (30 of 68 cases) outside the conserved regions. Eighteen of the 68 cases (26%) had mutations in the L3 loop, 11 of 68 (16%) in the L1 loop-sheet-alpha helix motif, and 39 of 68 (58%) outside L3 and loop-sheet-alpha helix. Seventy-five percent of the cases (120 of 160) showed DNA aneuploidy, whereas 18% of these (22 of 120) were multiclonal. The major independent predictors for both disease relapse and death were advanced Dukes' stage, p53 mutations affecting L3 loop, DNA-aneuploid tumors, and high SPF (18.5%). Our results show that mutations in L3 functional domain, more than any mutations, are important biological indicators to predict the outcome of patients indicating that these mutations have biological relevance in terms of colorectal cancer disease course.

Published
2002

33. Havep53 gene mutations and protein expression a different biological significance in colorectal cancer?

Author

BAZAN, Viviana, MIGLIAVACCA, Manuela, Tubiolo, C, Macaluso, M, Zanna, I, CORSALE, Simona, AMATO, Antonella, CALO', Valentina, Dardanoni, G, MORELLO, Vincenza, LA FARINA, Mario, ALBANESE, Ida, Tomasino, R, GEBBIA, Nicolo', RUSSO, Antonio, Bazan, V, Migliavacca, M, Tubiolo, C, Macaluso, M, Zanna, I, Corsale, S, Amato, A, Calò, V, Dardanoni, G, Morello, V, La Farina, M, Albanese, I, Tomasino, R, Gebbia, N, and Russo, A

Subjects
Adult, Aged, 80 and over, Male, Base Sequence, DNA Mutational Analysis, P53, colorectal cancer, DNA, Middle Aged, Genes, p53, Immunohistochemistry, Protein Structure, Tertiary, Gene Expression Regulation, Neoplastic, Mutation, Humans, Female, Genetic Testing, Prospective Studies, Intestinal Mucosa, Tumor Suppressor Protein p53, Colorectal Neoplasms, Aged
Abstract

p53 alterations are considered the most common genetic events in many types of neoplasms, including colorectal carcinoma (CRC). These alterations include mutations of the gene and/or overexpression of the protein. The aim of our study was to assess whether in 160 patients undergoing resective surgery for primary operable CRC there was an association between p53 mutations and protein over-expression and between these and other biological variables, such as cell DNA content (DNA-ploidy) and S-phase fraction (SPF), and the traditional clinicopathological variables. p53 mutations, identified by PCR-SSCP-sequencing analysis, were found in 68/160 patients (43%) and positive staining for p53 protein, detected with the monoclonal antibody DO-7, was present in 48% (77/160) of the cases, with agreement of 57% (91/160). In particular, a significant association was found between increased p53 expression and genetic alterations localized in the conserved regions of the gene or in the L3 DNA-binding domain and the specific type of mutation. Furthermore, both overexpression of p53 and mutations in the conserved areas of the gene were found more frequently in distal than in proximal CRCs, suggesting that they might be "biologically different diseases." Although p53 mutations in conserved areas were associated with flow cytometric variables, overexpression of p53 and mutations in its L3 domain were only related respectively to DNA-aneuploidy and high SPF. These data may reflect the complex involvement of p53 in the different pathways regulating cell-cycle progression. In conclusion, the combination of the mutational status and immunohistochemistry of p53, and flow cytometric data may provide an important insight into the biological features of CRCs.

Published
2002

34. Pleural malignant mesothelioma epidemic: incidence, modalities of asbestos exposure and occupations involved from the Italian National Register

Author

Marinaccio, A, Binazzi, A, Marzio, Dd, Scarselli, A, Verardo, M, Mirabelli, D, Gennaro, V, Mensi, C, Riboldi, L, Merler, E, Zotti, Rd, Romanelli, A, Chellini, E, Silvestri, S, Pascucci, C, Romeo, E, Menegozzo, S, Musti, M, Cavone, D, Cauzillo, G, Tumino, R, Nicita, C, Melis, M, Iavicoli, S, ReNaM Working Group, Massari, S, Branchi, C, Detragiache, E, Merletti, Franco, Gangemi, M, Stura, A, Brentisci, C, Cammarieri Diglio, G, Macerata, V, Gilardetti, M, Lazzarotto, A, Benfatto, L, Bianchelli, M, Mazzucco, G, Sieno, C, Pesatori, Ac, Gioffrè, F, Bressan, V, De Michieli, P, Mangone, L, Storchi, C, Seniori Costantini, A, Badiali, Am, Cacciarini, V, Giovannetti, L, Martini, A, Calisti, R, La Rosa, F, Stracci, F, D'Alò, D, Perucci, Ca, Forastiere, F, Cavariani, F, Ascoli, V, Sangalli, M, Trafficante, L, Gatta, S, Menegozzo, M, Izzo, F, Canfora, Ml, Santoro, M, Viscardi, F, Massaro, T, Convertini, L, Leotta, A, Lio, Sg, Dardanoni, G, Scondotto, S, Corrias, Ga, Angius, Mr, and Nieddu, V.

Subjects
Adult, Male, Mesothelioma, Cancer Research, medicine.medical_specialty, Pathology, Pleural Neoplasms, asbestos, italy, mesothelioma, national register, pleural, Developing country, medicine.disease_cause, Asbestos, Occupational safety and health, Environmental health, Occupational Exposure, Epidemiology, medicine, Humans, Epidemics, Pleural mesothelioma, Aged, business.industry, Incidence (epidemiology), Age Factors, Environmental exposure, Middle Aged, medicine.disease, Occupational Diseases, Oncology, Italy, Population Surveillance, Etiology, Female, business
Abstract

Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004, a case-list of 8,868 pleural MM was recorded by the Italian National Register (ReNaM) and the modalities of exposure to asbestos fibres have been investigated for 6,603 of them. Standardized incidence rates are 3.49 (per 100,000 inhabitants) for men and 1.25 for women, with a wide regional variability. Occupational asbestos exposure was in 69.3% of interviewed subjects (N = 4,577 cases), while 4.4% was due to cohabitation with someone (generally, the husband) occupationally exposed, 4.7% by environmental exposure from living near a contamination source and 1.6% during a leisure activity. In the male group, 81.5% of interviewed subjects exhibit an occupational exposure. In the exposed workers, the median year of first exposure was 1957, and mean latency was 43.7 years. The analysis of exposures by industrial sector focuses on a decreasing trend for those traditionally signaled as "at risk" (asbestos-cement industry, shipbuilding and repair and railway carriages maintenance) and an increasing trend for the building construction sector. The systematic mesothelioma surveillance system is relevant for the prevention of the disease and for supporting an efficient compensation system. The existing experience on all-too-predictable asbestos effects should be transferred to developing countries where asbestos use is spreading.

Published
2011

35. Flow cytometric DNA analysis and lysosomal cathepsins B and L in locally advanced laryngeal cancer. Relationship with clinicopathologic parameters and prognostic significance

Author

Russo A., Bazan V., Gebbia N., Pizzolanti G., Tumminello F. M., Dardanoni G., Ingria F., Restivo S., Tomasino R. M., Leto G., Russo A., Bazan V., Gebbia N., Pizzolanti G., Tumminello F.M., Dardanoni G., Ingria F., Restivo S., Tomasino R.M., and Leto G.

Subjects
Adult, Aged, 80 and over, Male, Cathepsin L, DNA, Neoplasm, Middle Aged, Aneuploidy, Flow Cytometry, Prognosis, Cathepsins, Cathepsin B, S Phase, Cysteine Endopeptidases, Endopeptidases, Humans, Female, cathepsin B and L, DNA ploidy, flow cytometry, laryngeal squamous cell carcinoma, S‐phase fraction, Lysosomes, Laryngeal Neoplasms, Aged
Abstract

Background. The traditional factors of locally advanced laryngeal squamous cell carcinoma (LSCC) have limited predictive value for the identification of high risk patients. Therefore, it is extremely important to define prognostic factors that identify the more aggressive types. Reliable and reproducible prognostic indicators are being investigated to help clinicians identify high risk groups and address more rational treatment. Methods. Flow cytometric DNA ploidy and S‐phase fraction (SPF) measurements were performed on frozen tumor tissues from a consecutive series of 71 patients with Stage III and IV LSCC. Lysosomal cathepsin B and L activity levels were determined biochemically in matched paired sets of tumor tissue and normal mucosa samples. Results. By univariate analysis, lymph node positivity, poor histologic differentiation, DNA aneuploidy, high SPF, and high tumor/mucosa ratio of cathepsin B activity were significantly related to risk of relapse, whereas only DNA aneuploidy and high SPF proved to be significantly related to risk of death. Multivariate analysis showed that high histologic grade and high SPF values (>15.1%) were independent prognostic factors related to risk of relapse (relative risk [RR] = 3.54; 95% confidence limits [CL] = 1.05‐12.0; and RR = 4.22; CL = 1.54‐11.6, respectively), whereas only high SPF was related to risk of death (RR = 3.63; CL = 1.17‐11.3). Conclusions. S‐phase fraction is an independent predictor of relapse free and overall survival in patients with locally advanced LSCC. On the basis of these findings, SPF should be used in addition to other established prognostic factors to refine the prognostic assessment of these patients further. More studies are needed for a better evaluation of the prognostic significance of DNA ploidy and that of lysosomal cysteine proteinases in these tumors. Cancer 1995; 76:1757–64. Copyright © 1995 American Cancer Society

Published
1995

39. Thymidilate syntetase gene promoter polymorphisms are associated with TSmRNA expressions but not with microsatellite instability in colorectal cancer

Author

Calascibetta, A., Cabibi, D., Martorana, A., Sanguedolce, G., Rausa, L., Feo, S., Dardanoni, G., and Sanguedolce, R.

Subjects
Settore BIO/14 - Farmacologia, Colorectal cancer, thymidylate synthase, pharmacogenomic, microsatellite instability, polymorphism, molecular therapeutic, Settore BIO/11 - Biologia Molecolare, Settore MED/08 - Anatomia Patologica
Published
2004

40. Prognostic significance of proliferative activity, DNA-ploidy, p53 and Ki-ras point mutations in colorectal liver metastases

Author

Russo, A., Migliavacca, M., Bazan, V., Maturi, N., Morello, V., Dardanoni, G., Modica, G., Bazan, P., Albanese, I., La Farina, M., and Tomasino, R. M.

Subjects
Adult, Male, S Phase, Biomarkers, Tumor, Humans, Point Mutation, Prospective Studies, Polymorphism, Single-Stranded Conformational, Aged, Original Paper, Ploidies, Liver Neoplasms, Nuclear Proteins, Antigens, Nuclear, Cell Biology, General Medicine, Middle Aged, Flow Cytometry, Genes, p53, Prognosis, Immunohistochemistry, Survival Rate, Genes, ras, Ki-67 Antigen, Multivariate Analysis, Female, Original Article, Colorectal Neoplasms
Abstract

Paired colorectal liver metastases (CLM) and normal tissue samples from a consecutive series of 36 patients were studied prospectively. MIB‐1 expression was studied by immunohistochemistry on paraffin‐embedded sections. DNA ploidy and S‐phase fraction (SPF) measurements were performed by flow cytometry on frozen tissues. Mutations within the p53 (exons 5‐8) and c‐Ki‐ras (codons 12 and 13) genes were detected by PCR single‐strand conformation polymorphism analysis followed by sequencing. A high correlation was observed between the MIB‐1 LI and SPF value (rho=0·81; P

Published
1998

41. Functional categories of TP53 mutation in colorectal cancer : results of an International Collaborative Study

Author

Iacopetta, B, Russo, A, Bazan, V, Dardanoni, G, Gebbia, N, Soussi, T, Kerr, D, Elsaleh, H, Soong, R, Kandioler, D, Janschek, E, Kappel, S, Lung, M, Leung, C-S S, Ko, J M, Sun, Xiao-Feng, Jansson, Agneta, Shorthouse, AJ, Silverman, ML, Kato, S, Ishioka, C, Iacopetta, B, Russo, A, Bazan, V, Dardanoni, G, Gebbia, N, Soussi, T, Kerr, D, Elsaleh, H, Soong, R, Kandioler, D, Janschek, E, Kappel, S, Lung, M, Leung, C-S S, Ko, J M, Sun, Xiao-Feng, Jansson, Agneta, Shorthouse, AJ, Silverman, ML, Kato, S, and Ishioka, C

Published
2006

44. The role of age at menarche and at menopause on breast cancer risk: combined evidence from four case-control studies

Author

Carlo La Vecchia, Negri E, Bruzzi P, Dardanoni G, Decarli A, Franceschi S, Palli D, and Talamini R

Subjects
Adult, Menarche, Risk, Adolescent, Case-Control Studies, Age Factors, Humans, Breast Neoplasms, Female, Menopause, Middle Aged, Aged
Abstract

The role of age at menarche and at menopause on breast cancer risk was reassessed in a combined analysis of four Italian case-control studies including a total of 6,075 cases and 5,492 controls. The risk of breast cancer was lower in women whose menarche occurred at age 15 or over, but there was no evidence for the risk to increase with decreasing age at menarche below age 15. Compared with women with earlier menarche, the relative risk (RR) was 0.9 (95% confidence interval, CI 0.7-1.0) for those with menarche at age 15, 0.8 (95% CI 0.6-0.9) for menarche at 16, and 0.7 (95% CI 0.5-0.8) for menarche at age 17 or over. There was no significant interaction between age at menarche and study centre or age at diagnosis, parity and age at first birth. In relation to age at menopause, compared with women whose menopause occurred at age 40 or less, the relative risk was 1.1 (95% CI 0.8-1.3) between 40 and 44, 1.2 (95% CI 0.9-1.4) between 45 and 49, 1.4 (95% CI 1.2-1.8) between 50 and 53, and 1.4 (95% CI 1.1-1.8) above 53. The risk estimates were comparable in various studies, and the trend in risk with age at menopause was statistically significant. The risk estimates tended to be somewhat higher at peri-menopausal age (45 to 54 years), but no consistent pattern was evident across subsequent strata of age, and the interaction with age was not significant. Likewise, no consistent interaction was observed with parity, age at first birth or body mass index.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1992

45. Independent regulatory agencies: Economic theory and institutional evidence

Author

V. Dardanoni, G. Sobbrio, Boitani, Andrea, A., Petretto, Boitani, Andrea (ORCID:0000-0003-1249-213X), V. Dardanoni, G. Sobbrio, Boitani, Andrea, A., Petretto, and Boitani, Andrea (ORCID:0000-0003-1249-213X)

Abstract

In this work we shall focus on regulatory authorities. In Great Britain the word “authority” designates both a proper regulatory agency, and a standard for profit firm. An example of the latter is the British Airport authority. However, the term “authority” is not associated in Britain with the independence from political power that in Italy is commonly implied. The autonomy of regulatory agencies, which are widespread also in the United States, have an that is limited by political power (to the point that such agencies are often called “government agencies”), and their decisions can be modified or even overturned by the Minister in charge or by Parliament. This type of agencies are found also in Italy, but we shall not include them among the “independent authorities” in this paper.

Published
2000

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