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1. An Analysis of Genetic Polymorphisms in 76 Genes Related to the Development of Ovarian Tumors of Different Aggressiveness.

Author: Szafron, Laura A., Sobiczewski, Piotr, Dansonka-Mieszkowska, Agnieszka, Kupryjanczyk, Jolanta, and Szafron, Lukasz M.
Abstract: Borderline ovarian tumors (BOTS) are rare neoplasms of intermediate aggressiveness between cystadenomas and low-grade ovarian cancers (lgOvCa), which they share some molecular resemblances with. In contrast to the most frequent and well-described high-grade ovarian carcinomas (hgOvCa), the molecular background of BOTS and lgOvCa is less thoroughly characterized. Here, we aimed to analyze genetic variants in crucial tumor suppressors and oncogenes in BOTS (with or without the BRAF V600E mutation), lgOvCa, and hgOvCa in two gene panels using next-generation sequencing. Then, we verified the existence of selected polymorphisms by Sanger sequencing. Finally, Western blot analyses were carried out to check the impact of the selected polymorphisms on the expression of the corresponding proteins. Our study contributes to the molecular characterization of ovarian neoplasms, demonstrating divergent polymorphic patterns pointing to distinct signaling pathways engaged in their development. Certain mutations seem to play an important role in BOTS without the BRAF V600E variant (KRAS) and in lgOvCa (KRAS and NRAS), but not in hgOvCa. Additionally, based on multivariable regression analyses, potential biomarkers in BOTS (PARP1) and hgOvCa (FANCI, BRCA2, TSC2, FANCF) were identified. Noteworthy, for some of the analyzed genes, such as FANCI, FANCD2, and FANCI, FANCF, TSC2, the status of BRCA1/2 and TP53, respectively, turned out to be crucial. Our results shed new light on the similarities and differences in the polymorphic patterns between ovarian tumors of diverse aggressiveness. Furthermore, the biomarkers identified herein are of potential use as predictors of the prognosis and/or response to therapy. [ABSTRACT FROM AUTHOR]
Published: 2024
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2. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

Author: Earp, Madalene, Tyrer, Jonathan P, Winham, Stacey J, Lin, Hui-Yi, Chornokur, Ganna, Dennis, Joe, Aben, Katja KH, Anton‐Culver, Hoda, Antonenkova, Natalia, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Høgdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Jung, Audrey Y, Karlan, Beth Y, Kellar, Melissa, Kiemeney, Lambertus A, Lim, Boon Kiong, Kjaer, Susanne K, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lele, Shashi, Lester, Jenny, Levine, Douglas A, Li, Zheng, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, Orsulic, Sandra, Paul, James, Pejovic, Tanja, Pelttari, Liisa M, Permuth, Jenny B, Pike, Malcolm C, Poole, Elizabeth M, Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H, and Runnebaum, Ingo B
Subjects: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Genetics, Oncology and Carcinogenesis, Biotechnology, Ovarian Cancer, Cancer, Human Genome, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, A Kinase Anchor Proteins, Carcinoma, Ovarian Epithelial, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Monomeric GTP-Binding Proteins, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Rho Guanine Nucleotide Exchange Factors, Risk Factors, General Science & Technology
Abstract: Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes such as signal transduction, cell proliferation, cell motility, and vesicle transport. We hypothesized that common germline variation in genes encoding small GTPases is associated with EOC risk. We investigated 322 variants in 88 small GTPase genes in germline DNA of 18,736 EOC patients and 26,138 controls of European ancestry using a custom genotype array and logistic regression fitting log-additive models. Functional annotation was used to identify biofeatures and expression quantitative trait loci that intersect with risk variants. One variant, ARHGEF10L (Rho guanine nucleotide exchange factor 10 like) rs2256787, was associated with increased endometrioid EOC risk (OR = 1.33, p = 4.46 x 10-6). Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059). Functional annotation revealed that the two ARHGEF10L variants were located in super-enhancer regions and that AKAP6 rs927062 was associated with expression of GTPase gene ARHGAP5 (Rho GTPase activating protein 5). Inherited variants in ARHGEF10L and AKAP6, with potential transcriptional regulatory function and association with EOC risk, warrant investigation in independent EOC study populations.
Published: 2018

3. The utility of fluorescence in situ hybridization (FISH) in determining DNA damage-inducible transcript 3 (DDIT3) amplification in dedifferentiated liposarcomas – an important diagnostic pitfall

Author: Kuczkiewicz-Siemion, Olga, Wiśniewski, Piotr, Dansonka-Mieszkowska, Agnieszka, Grabowska-Kierył, Magdalena, Olszewska, Katarzyna, Goryń, Tomasz, Prochorec-Sobieszek, Monika, Rutkowski, Piotr, and Szumera-Ciećkiewicz, Anna
Published: 2021
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4. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Author: Phelan, Catherine M, Kuchenbaecker, Karoline B, Tyrer, Jonathan P, Kar, Siddhartha P, Lawrenson, Kate, Winham, Stacey J, Dennis, Joe, Pirie, Ailith, Riggan, Marjorie J, Chornokur, Ganna, Earp, Madalene A, Lyra, Paulo C, Lee, Janet M, Coetzee, Simon, Beesley, Jonathan, McGuffog, Lesley, Soucy, Penny, Dicks, Ed, Lee, Andrew, Barrowdale, Daniel, Lecarpentier, Julie, Leslie, Goska, Aalfs, Cora M, Aben, Katja KH, Adams, Marcia, Adlard, Julian, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia, AOCS study group, Aravantinos, Gerasimos, Arnold, Norbert, Arun, Banu K, Arver, Brita, Azzollini, Jacopo, Balmaña, Judith, Banerjee, Susana N, Barjhoux, Laure, Barkardottir, Rosa B, Bean, Yukie, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q, Birrer, Michael J, Bjorge, Line, Black, Amanda, Blankstein, Kenneth, Blok, Marinus J, Bodelon, Clara, Bogdanova, Natalia, Bojesen, Anders, Bonanni, Bernardo, Borg, Åke, Bradbury, Angela R, Brenton, James D, Brewer, Carole, Brinton, Louise, Broberg, Per, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Buecher, Bruno, Butzow, Ralf, Buys, Saundra S, Caldes, Trinidad, Caligo, Maria A, Campbell, Ian, Cannioto, Rikki, Carney, Michael E, Cescon, Terence, Chan, Salina B, Chang-Claude, Jenny, Chanock, Stephen, Chen, Xiao Qing, Chiew, Yoke-Eng, Chiquette, Jocelyne, Chung, Wendy K, Claes, Kathleen BM, Conner, Thomas, Cook, Linda S, Cook, Jackie, Cramer, Daniel W, Cunningham, Julie M, D'Aloisio, Aimee A, Daly, Mary B, Damiola, Francesca, Damirovna, Sakaeva Dina, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Davidson, Rosemarie, DeFazio, Anna, Delnatte, Capucine, Doheny, Kimberly F, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer Anne, Domchek, Susan M, and Dorfling, Cecilia M
Subjects: AOCS study group, EMBRACE Study, GEMO Study Collaborators, HEBON Study, KConFab Investigators, OPAL study group, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Genetic Predisposition to Disease, Telomere-Binding Proteins, BRCA1 Protein, BRCA2 Protein, Risk Factors, Genotype, Mutation, Polymorphism, Single Nucleotide, Alleles, Female, Meta-Analysis as Topic, Genome-Wide Association Study, Genetic Loci, Carcinoma, Ovarian Epithelial, Genetics, Cancer, Human Genome, Rare Diseases, Prevention, Ovarian Cancer, Aetiology, 2.1 Biological and endogenous factors, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract: To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Published: 2017

5. No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival

Author: Sucheston-Campbell, Lara E, Cannioto, Rikki, Clay, Alyssa I, Etter, John Lewis, Eng, Kevin H, Liu, Song, Battaglia, Sebastiano, Hu, Qiang, Szender, J Brian, Minlikeeva, Albina, Joseph, Janine M, Mayor, Paul, Abrams, Scott I, Segal, Brahm H, Wallace, Paul K, Soh, Kah Teong, Zsiros, Emese, Anton-Culver, Hoda, Bandera, Elisa V, Beckmann, Matthias W, Berchuck, Andrew, Bjorge, Line, Bruegl, Amanda, Campbell, Ian G, Campbell, Shawn Patrice, Chenevix-Trench, Georgia, Study, on behalf of the Australian Ovarian Cancer, Cramer, Daniel W, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Diergaarde, Brenda, Doerk, Thilo, Doherty, Jennifer A, du Bois, Andreas, Eccles, Diana, Engelholm, Svend Aage, Fasching, Peter A, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Glasspool, Rosalind M, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hillemmanns, Peter, Høgdall, Claus, Høgdall, Estrid VS, Huzarski, Tomasz, Jensen, Allan, Johnatty, Sharon E, Jung, Audrey, Karlan, Beth Y, Klapdor, Reudiger, Kluz, Tomasz, Konopka, Bożena, Kjær, Susanne Krüger, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lester, Jenny, Lubiński, Jan, Levine, Douglas A, Lundvall, Lene, McGuire, Valerie, McNeish, Iain A, Menon, Usha, Modugno, Francesmary, Ness, Roberta B, Orsulic, Sandra, Paul, James, Pearce, Celeste Leigh, Pejovic, Tanja, Pharoah, Paul, Ramus, Susan J, Rothstein, Joseph, Rossing, Mary Anne, Rübner, Matthias, Schildkraut, Joellen M, Schmalfeldt, Barbara, Schwaab, Ira, Siddiqui, Nadeem, Sieh, Weiva, Sobiczewski, Piotr, Song, Honglin, Terry, Kathryn L, Van Nieuwenhuysen, Els, Vanderstichele, Adriaan, Vergote, Ignace, Walsh, Christine S, Webb, Penelope M, Wentzensen, Nicolas, Whittemore, Alice S, Wu, Anna H, Ziogas, Argyrios, Odunsi, Kunle, Chang-Claude, Jenny, Goode, Ellen L, and Moysich, Kirsten B
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Cancer, Ovarian Cancer, Rare Diseases, Prevention, Genetics, Genetic Testing, 2.1 Biological and endogenous factors, Aetiology, Carcinoma, Ovarian Epithelial, Female, Genetic Association Studies, Genetic Variation, Humans, Myeloid-Derived Suppressor Cells, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Australian Ovarian Cancer Study, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract: Background: The precise mechanism by which the immune system is adversely affected in cancer patients remains poorly understood, but the accumulation of immunosuppressive/protumorigenic myeloid-derived suppressor cells (MDSCs) is thought to be a prominent mechanism contributing to immunologic tolerance of malignant cells in epithelial ovarian cancer (EOC). To this end, we hypothesized genetic variation in MDSC pathway genes would be associated with survival after EOC diagnoses.Methods: We measured the hazard of death due to EOC within 10 years of diagnosis, overall and by invasive subtype, attributable to SNPs in 24 genes relevant in the MDSC pathway in 10,751 women diagnosed with invasive EOC. Versatile Gene-based Association Study and the admixture likelihood method were used to test gene and pathway associations with survival.Results: We did not identify individual SNPs that were significantly associated with survival after correction for multiple testing (P < 3.5 × 10-5), nor did we identify significant associations between the MDSC pathway overall, or the 24 individual genes and EOC survival.Conclusions: In this well-powered analysis, we observed no evidence that inherited variations in MDSC-associated SNPs, individual genes, or the collective genetic pathway contributed to EOC survival outcomes.Impact: Common inherited variation in genes relevant to MDSCs was not associated with survival in women diagnosed with invasive EOC. Cancer Epidemiol Biomarkers Prev; 26(3); 420-4. ©2016 AACR.
Published: 2017

6. Unique gastrointestinal stromal tumor with PDGFRA D842Y mutation—evaluation of in vivo sensitivity to imatinib

Author: Kuczkiewicz-Siemion, Olga, Dansonka-Mieszkowska, Agnieszka, Rutkowski, Piotr, Klimczak, Anna, Tysarowski, Andrzej, Prochorec-Sobieszek, Monika, and Szumera-Ciećkiewicz, Anna
Published: 2021
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7. Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration

Author: Permuth, Jennifer B, Reid, Brett, Earp, Madalene, Chen, Y Ann, Monteiro, Alvaro NA, Chen, Zhihua, Group, AOCS Study, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Lambrechts, Diether, Vanderstichele, Adriaan, Van Niewenhuyse, Els, Vergote, Ignace, Rossing, Mary Anne, Doherty, Jennifer Anne, Chang-Claude, Jenny, Moysich, Kirsten, Odunsi, Kunle, Goodman, Marc T, Shvetsov, Yurii B, Wilkens, Lynne R, Thompson, Pamela J, Dörk, Thilo, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa, Leminen, Arto, Modugno, Francesmary, Edwards, Robert P, Ness, Roberta B, Kelley, Joseph, Heitz, Florian, Karlan, Beth, Lester, Jenny, Kjaer, Susanne K, Jensen, Allan, Giles, Graham, Hildebrandt, Michelle, Liang, Dong, Lu, Karen H, Wu, Xifeng, Levine, Douglas A, Bisogna, Maria, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Tworoger, Shelley S, Poole, Elizabeth M, Bandera, Elisa V, Fridley, Brooke, Cunningham, Julie, Winham, Stacey J, Olson, Sara H, Orlow, Irene, Bjorge, Line, Kiemeney, Lambertus A, Massuger, Leon, Pejovic, Tanja, Moffitt, Melissa, Le, Nhu, Cook, Linda S, Brooks-Wilson, Angela, Kelemen, Linda E, Gronwald, Jacek, Lubinski, Jan, Wentzensen, Nicolas, Brinton, Louise A, Lissowska, Jolanta, Yang, Hanna, Hogdall, Estrid, Hogdall, Claus, Lundvall, Lene, Pharoah, Paul DP, Song, Honglin, Campbell, Ian, Eccles, Diana, McNeish, Iain, Whittemore, Alice, McGuire, Valerie, Sieh, Weiva, Rothstein, Joseph, Phelan, Catherine M, Risch, Harvey, Narod, Steven, McLaughlin, John, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Pearce, Celeste Leigh, Wu, Anna H, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Schildkraut, Joellen M, Cheng, Jin Q, and Goode, Ellen L
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Ovarian Cancer, Cancer, Genetics, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Animals, Disease Susceptibility, Female, Genetic Variation, Humans, Middle Aged, Ovarian Neoplasms, Polymorphism, Single Nucleotide, RNA Editing, polymorphisms, RNA editing, ovarian cancer risk, AOCS Study Group, Oncology and carcinogenesis
Abstract: RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypothesized that single nucleotide polymorphisms (SNPs) in ADAR genes modify EOC susceptibility, potentially by altering ovarian tissue gene expression. Using directly genotyped and imputed data from 10,891 invasive EOC cases and 21,693 controls, we evaluated the associations of 5,303 SNPs in ADAD1, ADAR, ADAR2, ADAR3, and SND1. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI), with adjustment for European ancestry. We conducted gene-level analyses using the Admixture Maximum Likelihood (AML) test and the Sequence-Kernel Association test for common and rare variants (SKAT-CR). Association analysis revealed top risk-associated SNP rs77027562 (OR (95% CI)= 1.39 (1.17-1.64), P=1.0x10-4) in ADAR3 and rs185455523 in SND1 (OR (95% CI)= 0.68 (0.56-0.83), P=2.0x10-4). When restricting to serous histology (n=6,500), the magnitude of association strengthened for rs185455523 (OR=0.60, P=1.0x10-4). Gene-level analyses revealed that variation in ADAR was associated (P
Published: 2016

8. Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

Author: Hampras, Shalaka S, Sucheston-Campbell, Lara E, Cannioto, Rikki, Chang-Claude, Jenny, Modugno, Francesmary, Dörk, Thilo, Hillemanns, Peter, Preus, Leah, Knutson, Keith L, Wallace, Paul K, Hong, Chi-Chen, Friel, Grace, Davis, Warren, Nesline, Mary, Pearce, Celeste L, Kelemen, Linda E, Goodman, Marc T, Bandera, Elisa V, Terry, Kathryn L, Schoof, Nils, Eng, Kevin H, Clay, Alyssa, Singh, Prashant K, Joseph, Janine M, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bean, Yukie, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Cook, Linda S, Cramer, Daniel W, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, du Bois, Andreas, Dürst, Matthias, Easton, Doug, Eccles, Diana, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hogdall, Claus, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Klapdor, Rüdiger, Kolomeyevskaya, Nonna, Krakstad, Camilla, Kjaer, Susanne K, Kruszka, Bridget, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashikant, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Liu, Song, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, and McGuire, Valeria
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Ovarian Cancer, Rare Diseases, Cancer, Genetics, 2.1 Biological and endogenous factors, Aetiology, Adenocarcinoma, Clear Cell, Adult, Aged, Carcinoma, Ovarian Epithelial, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Protein Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Risk Factors, T-Lymphocytes, Regulatory, ovarian cancer, immunosuppression, biomarkers, genetic variation, TGFBR2, TGFBR2, Oncology and carcinogenesis
Abstract: BackgroundRegulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.MethodsIn a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.ResultsThe most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).ConclusionsCommon inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.
Published: 2016

9. Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.

Author: Ong, Jue-Sheng, Cuellar-Partida, Gabriel, Lu, Yi, Australian Ovarian Cancer Study, Fasching, Peter A, Hein, Alexander, Burghaus, Stefanie, Beckmann, Matthias W, Lambrechts, Diether, Van Nieuwenhuysen, Els, Vergote, Ignace, Vanderstichele, Adriaan, Anne Doherty, Jennifer, Anne Rossing, Mary, Chang-Claude, Jenny, Eilber, Ursula, Rudolph, Anja, Wang-Gohrke, Shan, Goodman, Marc T, Bogdanova, Natalia, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo B, Antonenkova, Natalia, Butzow, Ralf, Leminen, Arto, Nevanlinna, Heli, Pelttari, Liisa M, Edwards, Robert P, Kelley, Joseph L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Cannioto, Rikki, Høgdall, Estrid, Høgdall, Claus K, Jensen, Allan, Giles, Graham G, Bruinsma, Fiona, Kjaer, Susanne K, Hildebrandt, Michelle At, Liang, Dong, Lu, Karen H, Wu, Xifeng, Bisogna, Maria, Dao, Fanny, Levine, Douglas A, Cramer, Daniel W, Terry, Kathryn L, Tworoger, Shelley S, Stampfer, Meir, Missmer, Stacey, Bjorge, Line, Salvesen, Helga B, Kopperud, Reidun K, Bischof, Katharina, Aben, Katja Kh, Kiemeney, Lambertus A, Massuger, Leon Fag, Brooks-Wilson, Angela, Olson, Sara H, McGuire, Valerie, Rothstein, Joseph H, Sieh, Weiva, Whittemore, Alice S, Cook, Linda S, Le, Nhu D, Gilks, C Blake, Gronwald, Jacek, Jakubowska, Anna, Lubiński, Jan, Kluz, Tomasz, Song, Honglin, Tyrer, Jonathan P, Wentzensen, Nicolas, Brinton, Louise, Trabert, Britton, Lissowska, Jolanta, McLaughlin, John R, Narod, Steven A, Phelan, Catherine, Anton-Culver, Hoda, Ziogas, Argyrios, Eccles, Diana, Campbell, Ian, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Menon, Usha, Ramus, Susan J, Wu, Anna H, Dansonka-Mieszkowska, Agnieszka, Kupryjanczyk, Jolanta, Timorek, Agnieszka, Szafron, Lukasz, Cunningham, Julie M, Fridley, Brooke L, Winham, Stacey J, Bandera, Elisa V, and Poole, Elizabeth M
Subjects: Australian Ovarian Cancer Study, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Genetic Predisposition to Disease, Vitamin D, Odds Ratio, Risk Factors, Polymorphism, Single Nucleotide, Female, Mendelian Randomization Analysis, Carcinoma, Ovarian Epithelial, Neoplasms, Glandular and Epithelial, Polymorphism, Single Nucleotide, Carcinoma, Ovarian Epithelial, Prevention, Rare Diseases, Nutrition, Clinical Research, Cancer, Ovarian Cancer, Statistics, Public Health and Health Services, Epidemiology
Abstract: BackgroundIn vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer.MethodsWe employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases).ResultsThe odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01).ConclusionsGenetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer.
Published: 2016

10. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Author: Lawrenson, Kate, Kar, Siddhartha, McCue, Karen, Kuchenbaeker, Karoline, Michailidou, Kyriaki, Tyrer, Jonathan, Beesley, Jonathan, Ramus, Susan J, Li, Qiyuan, Delgado, Melissa K, Lee, Janet M, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Arun, Banu K, Arver, Brita, Bandera, Elisa V, Barile, Monica, Barkardottir, Rosa B, Barrowdale, Daniel, Beckmann, Matthias W, Benitez, Javier, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Blomqvist, Carl, Blot, William, Bogdanova, Natalia, Bojesen, Anders, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Børresen-Dale, Anne-Lise, Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Bruinsma, Fiona, Brunet, Joan, Buhari, Shaik Ahmad, Burwinkel, Barbara, Butzow, Ralf, Buys, Saundra S, Cai, Qiuyin, Caldes, Trinidad, Campbell, Ian, Canniotto, Rikki, Chang-Claude, Jenny, Chiquette, Jocelyne, Choi, Ji-Yeob, Claes, Kathleen BM, GEMO Study Collaborators, Cook, Linda S, Cox, Angela, Cramer, Daniel W, Cross, Simon S, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, Damiola, Francesca, Dansonka-Mieszkowska, Agnieszka, Darabi, Hatef, Dennis, Joe, Devilee, Peter, Diez, Orland, Doherty, Jennifer A, Domchek, Susan M, Dorfling, Cecilia M, Dörk, Thilo, Dumont, Martine, Ehrencrona, Hans, Ejlertsen, Bent, Ellis, Steve, EMBRACE, Engel, Christoph, Lee, Eunjung, Evans, D Gareth, Fasching, Peter A, Feliubadalo, Lidia, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Foretova, Lenka, Fostira, Florentia, Foulkes, William D, Fridley, Brooke L, Friedman, Eitan, Frost, Debra, Gambino, Gaetana, Ganz, Patricia A, Garber, Judy, García-Closas, Montserrat, Gentry-Maharaj, Aleksandra, Ghoussaini, Maya, Giles, Graham G, Glasspool, Rosalind, Godwin, Andrew K, Goldberg, Mark S, and Goldgar, David E
Subjects: GEMO Study Collaborators, EMBRACE, Hereditary Breast and Ovarian Cancer Research Group Netherlands, KConFab Investigators, Australian Ovarian Cancer Study Group, Chromosomes, Human, Pair 19, Humans, Breast Neoplasms, Ovarian Neoplasms, Genetic Predisposition to Disease, RNA, Messenger, Genotype, Polymorphism, Single Nucleotide, Alleles, African Continental Ancestry Group, Asian Continental Ancestry Group, Female, Genome-Wide Association Study, Chromosomes, Human, Pair 19, RNA, Messenger, Polymorphism, Single Nucleotide, Prevention, Breast Cancer, Ovarian Cancer, Cancer, Rare Diseases, Genetics, 2.1 Biological and endogenous factors
Abstract: A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10(-3)) and ABHD8 (P
Published: 2016

11. Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author: Kar, Siddhartha P, Beesley, Jonathan, Olama, Ali Amin Al, Michailidou, Kyriaki, Tyrer, Jonathan, Kote-Jarai, ZSofia, Lawrenson, Kate, Lindstrom, Sara, Ramus, Susan J, Thompson, Deborah J, Investigators, ABCTB, Kibel, Adam S, Dansonka-Mieszkowska, Agnieszka, Michael, Agnieszka, Dieffenbach, Aida K, Gentry-Maharaj, Aleksandra, Whittemore, Alice S, Wolk, Alicja, Monteiro, Alvaro, Peixoto, Ana, Kierzek, Andrzej, Cox, Angela, Rudolph, Anja, Gonzalez-Neira, Anna, Wu, Anna H, Lindblom, Annika, Swerdlow, Anthony, Study, AOCS Study Group amp Australian Cancer, BioResource, APCB, Ziogas, Argyrios, Ekici, Arif B, Burwinkel, Barbara, Karlan, Beth Y, Nordestgaard, Børge G, Blomqvist, Carl, Phelan, Catherine, McLean, Catriona, Pearce, Celeste Leigh, Vachon, Celine, Cybulski, Cezary, Slavov, Chavdar, Stegmaier, Christa, Maier, Christiane, Ambrosone, Christine B, Høgdall, Claus K, Teerlink, Craig C, Kang, Daehee, Tessier, Daniel C, Schaid, Daniel J, Stram, Daniel O, Cramer, Daniel W, Neal, David E, Eccles, Diana, Flesch-Janys, Dieter, Edwards, Digna R Velez, Wokozorczyk, Dominika, Levine, Douglas A, Yannoukakos, Drakoulis, Sawyer, Elinor J, Bandera, Elisa V, Poole, Elizabeth M, Goode, Ellen L, Khusnutdinova, Elza, Høgdall, Estrid, Song, Fengju, Bruinsma, Fiona, Heitz, Florian, Modugno, Francesmary, Hamdy, Freddie C, Wiklund, Fredrik, Giles, Graham G, Olsson, Håkan, Wildiers, Hans, Ulmer, Hans-Ulrich, Pandha, Hardev, Risch, Harvey A, Darabi, Hatef, Salvesen, Helga B, Nevanlinna, Heli, Gronberg, Henrik, Brenner, Hermann, Brauch, Hiltrud, Anton-Culver, Hoda, Song, Honglin, Lim, Hui-Yi, McNeish, Iain, Campbell, Ian, Vergote, Ignace, Gronwald, Jacek, Lubiński, Jan, Stanford, Janet L, Benítez, Javier, Doherty, Jennifer A, Permuth, Jennifer B, Chang-Claude, Jenny, Donovan, Jenny L, Dennis, Joe, Schildkraut, Joellen M, Schleutker, Johanna, and Hopper, John L
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Breast Cancer, Aging, Urologic Diseases, Prostate Cancer, Ovarian Cancer, Rare Diseases, Human Genome, Cancer, Aetiology, 2.1 Biological and endogenous factors, Breast Neoplasms, Case-Control Studies, Chromosome Mapping, Datasets as Topic, Enhancer Elements, Genetic, Female, Gene Regulatory Networks, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Meta-Analysis as Topic, Organ Specificity, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Quantitative Trait Loci, Signal Transduction, ABCTB Investigators, AOCS Study Group & Australian Cancer Study, APCB BioResource, kConFab Investigators, NBCS Investigators, GENICA Network, PRACTICAL consortium, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract: UnlabelledBreast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis.SignificanceWe demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052-67. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 932.
Published: 2016

12. Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

Author: Cuellar-Partida, Gabriel, Lu, Yi, Dixon, Suzanne C, Australian Ovarian Cancer Study, Fasching, Peter A, Hein, Alexander, Burghaus, Stefanie, Beckmann, Matthias W, Lambrechts, Diether, Van Nieuwenhuysen, Els, Vergote, Ignace, Vanderstichele, Adriaan, Doherty, Jennifer Anne, Rossing, Mary Anne, Chang-Claude, Jenny, Rudolph, Anja, Wang-Gohrke, Shan, Goodman, Marc T, Bogdanova, Natalia, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo B, Antonenkova, Natalia, Butzow, Ralf, Leminen, Arto, Nevanlinna, Heli, Pelttari, Liisa M, Edwards, Robert P, Kelley, Joseph L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Cannioto, Rikki, Høgdall, Estrid, Høgdall, Claus, Jensen, Allan, Giles, Graham G, Bruinsma, Fiona, Kjaer, Susanne K, Hildebrandt, Michelle AT, Liang, Dong, Lu, Karen H, Wu, Xifeng, Bisogna, Maria, Dao, Fanny, Levine, Douglas A, Cramer, Daniel W, Terry, Kathryn L, Tworoger, Shelley S, Stampfer, Meir, Missmer, Stacey, Bjorge, Line, Salvesen, Helga B, Kopperud, Reidun K, Bischof, Katharina, Aben, Katja KH, Kiemeney, Lambertus A, Massuger, Leon FAG, Brooks-Wilson, Angela, Olson, Sara H, McGuire, Valerie, Rothstein, Joseph H, Sieh, Weiva, Whittemore, Alice S, Cook, Linda S, Le, Nhu D, Blake Gilks, C, Gronwald, Jacek, Jakubowska, Anna, Lubiński, Jan, Kluz, Tomasz, Song, Honglin, Tyrer, Jonathan P, Wentzensen, Nicolas, Brinton, Louise, Trabert, Britton, Lissowska, Jolanta, McLaughlin, John R, Narod, Steven A, Phelan, Catherine, Anton-Culver, Hoda, Ziogas, Argyrios, Eccles, Diana, Campbell, Ian, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Menon, Usha, Ramus, Susan J, Wu, Anna H, Dansonka-Mieszkowska, Agnieszka, Kupryjanczyk, Jolanta, Timorek, Agnieszka, Szafron, Lukasz, Cunningham, Julie M, Fridley, Brooke L, Winham, Stacey J, Bandera, Elisa V, Poole, Elizabeth M, and Morgan, Terry K
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Obesity, Women's Health, Cancer Genomics, Ovarian Cancer, Cancer, Human Genome, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Carcinoma, Ovarian Epithelial, Female, Genotype, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Pathology, Molecular, Polymorphism, Single Nucleotide, Australian Ovarian Cancer Study, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity, Reproductive medicine
Abstract: Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To this end, we used data of 10,014 invasive EOC patients and 21,233 controls from the Ovarian Cancer Association Consortium genotyped in the iCOGS array (211,155 SNPs). We estimate the array heritability (attributable to variants tagged on arrays) of each subtype and their genetic correlations. We also look for genetic overlaps with factors such as obesity, smoking behaviors, diabetes, age at menarche and height. We estimated the array heritabilities of high-grade serous disease ([Formula: see text] = 8.8 ± 1.1 %), endometrioid ([Formula: see text] = 3.2 ± 1.6 %), clear cell ([Formula: see text] = 6.7 ± 3.3 %) and all EOC ([Formula: see text] = 5.6 ± 0.6 %). Known associated loci contributed approximately 40 % of the total array heritability for each subtype. The contribution of each chromosome to the total heritability was not proportional to chromosome size. Through bivariate and cross-trait LD score regression, we found evidence of shared genetic backgrounds between the three high-grade subtypes: serous, endometrioid and undifferentiated. Finally, we found significant genetic correlations of all EOC with diabetes and obesity using a polygenic prediction approach.
Published: 2016

13. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Author: Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Hollestelle, Antoinette, van der Baan, Frederieke H, Berchuck, Andrew, Johnatty, Sharon E, Aben, Katja K, Agnarsson, Bjarni A, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Antoniou, Antonis C, Apicella, Carmel, Arndt, Volker, Arnold, Norbert, Arun, Banu K, Arver, Brita, Ashworth, Alan, Group, Australian Ovarian Cancer Study, Baglietto, Laura, Balleine, Rosemary, Bandera, Elisa V, Barrowdale, Daniel, Bean, Yukie T, Beckmann, Lars, Beckmann, Matthias W, Benitez, Javier, Berger, Andreas, Berger, Raanan, Beuselinck, Benoit, Bisogna, Maria, Bjorge, Line, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Anders, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Brand, Judith S, Brauch, Hiltrud, Register, Breast Cancer Family, Brenner, Hermann, Brinton, Louise, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Brüning, Thomas, Budzilowska, Agnieszka, Bunker, Clareann H, Burwinkel, Barbara, Butzow, Ralf, Buys, Saundra S, Caligo, Maria A, Campbell, Ian, Carter, Jonathan, Chang-Claude, Jenny, Chanock, Stephen J, Claes, Kathleen BM, Collée, J Margriet, Cook, Linda S, Couch, Fergus J, Cox, Angela, Cramer, Daniel, Cross, Simon S, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Damiola, Francesca, Dansonka-Mieszkowska, Agnieszka, Darabi, Hatef, de la Hoya, Miguel, deFazio, Anna, Dennis, Joseph, Devilee, Peter, Dicks, Ed M, Diez, Orland, Doherty, Jennifer A, Domchek, Susan M, Dorfling, Cecilia M, Dörk, Thilo, Dos Santos Silva, Isabel, du Bois, Andreas, Dumont, Martine, Dunning, Alison M, Duran, Mercedes, Easton, Douglas F, Eccles, Diana, Edwards, Robert P, Ehrencrona, Hans, Ejlertsen, Bent, Ekici, Arif B, Ellis, Steve D, EMBRACE, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Feliubadalo, Lidia, Figueroa, Jonine, and Flesch-Janys, Dieter
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Prevention, Breast Cancer, Clinical Trials and Supportive Activities, Genetic Testing, Ovarian Cancer, Women's Health, Rare Diseases, Cancer, Genetics, 2.1 Biological and endogenous factors, Breast Neoplasms, Carcinoma, Ovarian Epithelial, Female, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Proto-Oncogene Proteins p21(ras), KRAS variant, Breast cancer, Ovarian cancer, Genetic association, Clinical outcome, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2, Australian Ovarian Cancer Study Group, Breast Cancer Family Register, EMBRACE, GEMO Study Collaborators, GENICA Network, HEBON, KConFab Investigators, SWE-BRCA, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis, Reproductive medicine
Abstract: ObjectiveClinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370.MethodsCentralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers).ResultsWe found no association with risk of ovarian cancer (OR=0.99, 95% CI 0.94-1.04, p=0.74) or breast cancer (OR=0.98, 95% CI 0.94-1.01, p=0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR=1.09, 95% CI 0.97-1.23, p=0.14, breast cancer HR=1.04, 95% CI 0.97-1.12, p=0.27; BRCA2, ovarian cancer HR=0.89, 95% CI 0.71-1.13, p=0.34, breast cancer HR=1.06, 95% CI 0.94-1.19, p=0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR=0.94, 95% CI 0.83-1.07, p=0.38), breast cancer (HR=0.96, 95% CI 0.87-1.06, p=0.38), and all other previously-reported associations.Conclusionsrs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
Published: 2016

14. Evidence of a genetic link between endometriosis and ovarian cancer

Author: Lee, Alice W, Templeman, Claire, Stram, Douglas A, Beesley, Jonathan, Tyrer, Jonathan, Berchuck, Andrew, Pharoah, Paul P, Chenevix-Trench, Georgia, Pearce, Celeste Leigh, Consortium, Ovarian Cancer Association, Ness, Roberta B, Dansonka-Mieszkowska, Agnieszka, Gentry-Maharaj, Aleksandra, Hein, Alexander, Whittemore, Alice S, Jensen, Allan, du Bois, Andreas, Brooks-Wilson, Angela, Rudolph, Anja, Jakubowska, Anna, Wu, Anna H, Ziogas, Argyrios, Ekici, Arif B, Leminen, Arto, Study, Australian Cancer, Group, Australian Ovarian Cancer Study, Rosen, Barry, Spiewankiewicz, Beata, Karlan, Beth Y, Trabert, Britton, Fridley, Brooke L, Gilks, C Blake, Krakstad, Camilla, Phelan, Catherine M, Cybulski, Cezary, Walsh, Christine, Hogdall, Claus, Cramer, Daniel W, Huntsman, David G, Eccles, Diana, Lambrechts, Diether, Liang, Dong, Levine, Douglas A, Iversen, Edwin S, Bandera, Elisa V, Poole, Elizabeth M, Goode, Ellen L, Van Nieuwenhuysen, Els, Hogdall, Estrid, Bruinsma, Fiona, Heitz, Florian, Modugno, Francesmary, Giles, Graham G, Risch, Harvey A, Baker, Helen, Salvesen, Helga B, Nevanlinna, Heli, Anton-Culver, Hoda, Song, Honglin, McNeish, Iain, Campbell, Ian G, Vergote, Ignace, Runnebaum, Ingo B, Tangen, Ingvild L, Schwaab, Ira, Gronwald, Jacek, Paul, James, Lubinski, Jan, Doherty, Jennifer A, Chang-Claude, Jenny, Lester, Jenny, Schildkraut, Joellen M, McLaughlin, John R, Lissowska, Jolanta, Kupryjanczyk, Jolanta, Kelley, Joseph L, Rothstein, Joseph H, Cunningham, Julie M, Lu, Karen, Carty, Karen, Terry, Kathryn L, Aben, Katja KH, Moysich, Kirsten B, Wicklund, Kristine G, Odunsi, Kunle, Kiemeney, Lambertus A, Sucheston-Campbell, Lara, Lundvall, Lene, Massuger, Leon FAG, Pelttari, Liisa M, Kelemen, Linda E, Cook, Linda S, Bjorge, Line, Nedergaard, Lotte, Brinton, Louise A, Wilkens, Lynne R, Pike, Malcolm C, Goodman, Marc T, and Bisogna, Maria
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Cancer, Rare Diseases, Ovarian Cancer, Genetics, Genetic Testing, Clinical Research, Endometriosis, 2.1 Biological and endogenous factors, Aetiology, Case-Control Studies, Computational Biology, Databases, Genetic, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Neoplasm Grading, Ovarian Neoplasms, Phenotype, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Ovarian Cancer Association Consortium, SNPs, genetic variation, ovarian cancer, Clinical Sciences, Paediatrics and Reproductive Medicine, Public Health and Health Services, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract: ObjectiveTo evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.DesignPooled genetic analysis.SettingUniversity hospital.Patient(s)Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies.Intervention(s)None.Main outcome measure(s)Endometriosis-associated genetic variation and ovarian cancer.Result(s)There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected.Conclusion(s)By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.
Published: 2016

15. Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

Author: Johnatty, Sharon E, Group, on behalf of the Australian Ovarian Cancer Study, Tyrer, Jonathan P, Kar, Siddhartha, Beesley, Jonathan, Lu, Yi, Gao, Bo, Fasching, Peter A, Hein, Alexander, Ekici, Arif B, Beckmann, Matthias W, Lambrechts, Diether, Van Nieuwenhuysen, Els, Vergote, Ignace, Lambrechts, Sandrina, Rossing, Mary Anne, Doherty, Jennifer A, Chang-Claude, Jenny, Modugno, Francesmary, Ness, Roberta B, Moysich, Kirsten B, Levine, Douglas A, Kiemeney, Lambertus A, Massuger, Leon FAG, Gronwald, Jacek, Lubiński, Jan, Jakubowska, Anna, Cybulski, Cezary, Brinton, Louise, Lissowska, Jolanta, Wentzensen, Nicolas, Song, Honglin, Rhenius, Valerie, Campbell, Ian, Eccles, Diana, Sieh, Weiva, Whittemore, Alice S, McGuire, Valerie, Rothstein, Joseph H, Sutphen, Rebecca, Anton-Culver, Hoda, Ziogas, Argyrios, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Menon, Usha, Ramus, Susan J, Pearce, Celeste L, Pike, Malcolm C, Stram, Daniel O, Wu, Anna H, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Rzepecka, Iwona K, Spiewankiewicz, Beata, Goodman, Marc T, Wilkens, Lynne R, Carney, Michael E, Thompson, Pamela J, Heitz, Florian, du Bois, Andreas, Schwaab, Ira, Harter, Philipp, Pisterer, Jacobus, Hillemanns, Peter, Group, on behalf of the AGO Study, Karlan, Beth Y, Walsh, Christine, Lester, Jenny, Orsulic, Sandra, Winham, Stacey J, Earp, Madalene, Larson, Melissa C, Fogarty, Zachary C, Høgdall, Estrid, Jensen, Allan, Kjaer, Susanne Kruger, Fridley, Brooke L, Cunningham, Julie M, Vierkant, Robert A, Schildkraut, Joellen M, Iversen, Edwin S, Terry, Kathryn L, Cramer, Daniel W, Bandera, Elisa V, Orlow, Irene, Pejovic, Tanja, Bean, Yukie, Høgdall, Claus, Lundvall, Lene, McNeish, Ian, Paul, James, Carty, Karen, Siddiqui, Nadeem, Glasspool, Rosalind, Sellers, Thomas, Kennedy, Catherine, Chiew, Yoke-Eng, Berchuck, Andrew, MacGregor, Stuart, and Pharoah, Paul DP
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Orphan Drug, Genetics, Human Genome, Precision Medicine, Rare Diseases, Women's Health, Cancer Genomics, Ovarian Cancer, Cancer, 2.1 Biological and endogenous factors, Aetiology, Alleles, Carcinoma, Ovarian Epithelial, Computational Biology, Female, Genome-Wide Association Study, Genotype, Humans, Kaplan-Meier Estimate, Meta-Analysis as Topic, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Patient Outcome Assessment, Polymorphism, Single Nucleotide, Prognosis, Quantitative Trait Loci, AGO Study Group, Australian Ovarian Cancer Study Group, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract: PurposeChemotherapy resistance remains a major challenge in the treatment of ovarian cancer. We hypothesize that germline polymorphisms might be associated with clinical outcome.Experimental designWe analyzed approximately 2.8 million genotyped and imputed SNPs from the iCOGS experiment for progression-free survival (PFS) and overall survival (OS) in 2,901 European epithelial ovarian cancer (EOC) patients who underwent first-line treatment of cytoreductive surgery and chemotherapy regardless of regimen, and in a subset of 1,098 patients treated with ≥ 4 cycles of paclitaxel and carboplatin at standard doses. We evaluated the top SNPs in 4,434 EOC patients, including patients from The Cancer Genome Atlas. In addition, we conducted pathway analysis of all intragenic SNPs and tested their association with PFS and OS using gene set enrichment analysis.ResultsFive SNPs were significantly associated (P ≤ 1.0 × 10(-5)) with poorer outcomes in at least one of the four analyses, three of which, rs4910232 (11p15.3), rs2549714 (16q23), and rs6674079 (1q22), were located in long noncoding RNAs (lncRNAs) RP11-179A10.1, RP11-314O13.1, and RP11-284F21.8, respectively (P ≤ 7.1 × 10(-6)). ENCODE ChIP-seq data at 1q22 for normal ovary show evidence of histone modification around RP11-284F21.8, and rs6674079 is perfectly correlated with another SNP within the super-enhancer MEF2D, expression levels of which were reportedly associated with prognosis in another solid tumor. YAP1- and WWTR1 (TAZ)-stimulated gene expression and high-density lipoprotein (HDL)-mediated lipid transport pathways were associated with PFS and OS, respectively, in the cohort who had standard chemotherapy (pGSEA ≤ 6 × 10(-3)).ConclusionsWe have identified SNPs in three lncRNAs that might be important targets for novel EOC therapies.
Published: 2015

16. Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.

Author: Amankwah, Ernest K, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Chornokur, Ganna, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chen, Zhihua, Chen, Y Ann, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis N, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Jim, Heather, Kellar, Melissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Ian, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, Orsulic, Sandra, and Weber, Rachel Palmieri
Subjects: Georgia Chenevix-Trench on behalf of the AOCS management group, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Genetic Predisposition to Disease, Odds Ratio, Risk, Genotype, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, European Continental Ancestry Group, Female, Genome-Wide Association Study, Epithelial-Mesenchymal Transition, Carcinoma, Ovarian Epithelial, epithelial-mesenchymal transition, ovarian cancer, single-nucleotide polymorphisms, Neoplasms, Glandular and Epithelial, Polymorphism, Single Nucleotide, Carcinoma, Ovarian Epithelial, Epidemiology, Public Health and Health Services, Genetics
Abstract: Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value
Published: 2015

17. Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Author: Kar, Siddhartha P, Tyrer, Jonathan P, Li, Qiyuan, Lawrenson, Kate, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Chenevix-Trench, Georgia, Australian Cancer Study, Australian Ovarian Cancer Study Group, Baker, Helen, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjørge, Line, Bogdanova, Natalia, Brinton, Louise, Brooks-Wilson, Angela, Butzow, Ralf, Campbell, Ian, Carty, Karen, Chang-Claude, Jenny, Chen, Yian Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas F, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus K, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Paul, James, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kjaer, Susanne K, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain A, Menon, Usha, Modugno, Francesmary, Moysich, Kirsten B, Narod, Steven A, Nedergaard, Lotte, Ness, Roberta B, Nevanlinna, Heli, Odunsi, Kunle, Olson, Sara H, and Orlow, Irene
Subjects: Australian Cancer Study, Australian Ovarian Cancer Study Group, Humans, Cystadenocarcinoma, Serous, Ovarian Neoplasms, Genetic Predisposition to Disease, Nuclear Proteins, Transcription Factors, DNA, Neoplasm, Morbidity, Risk Factors, Gene Expression Regulation, Neoplastic, Genotype, Female, Genome-Wide Association Study, Global Health, Ovarian Cancer, Biotechnology, Cancer, Genetics, Rare Diseases, Prevention, Human Genome, 2.1 Biological and endogenous factors, Epidemiology, Medical and Health Sciences
Abstract: BackgroundGenome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative target genes of these TFs as identified by coexpression may also be enriched for additional EOC risk associations.MethodsWe selected TF genes within 1 Mb of the top signal at the 12 genome-wide significant risk loci. Mutual information, a form of correlation, was used to build networks of genes strongly coexpressed with each selected TF gene in the unified microarray dataset of 489 serous EOC tumors from The Cancer Genome Atlas. Genes represented in this dataset were subsequently ranked using a gene-level test based on results for germline SNPs from a serous EOC GWAS meta-analysis (2,196 cases/4,396 controls).ResultsGene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05). These results were replicated (P < 0.05) using an independent association study (7,035 cases/21,693 controls). Genes underlying enrichment in the six networks were pooled into a combined network.ConclusionWe identified a HOX-centric network associated with serous EOC risk containing several genes with known or emerging roles in serous EOC development.ImpactNetwork analysis integrating large, context-specific datasets has the potential to offer mechanistic insights into cancer susceptibility and prioritize genes for experimental characterization.
Published: 2015

18. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.

Author: Lawrenson, Kate, Li, Qiyuan, Kar, Siddhartha, Seo, Ji-Heui, Tyrer, Jonathan, Spindler, Tassja J, Lee, Janet, Chen, Yibu, Karst, Alison, Drapkin, Ronny, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Australian Ovarian Cancer Study Group, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Chen, Anne, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas T, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, James, Paul, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kruger Kjaer, Susanne, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, Nevanlinna, Heli, McNeish, Ian, and Menon, Usha
Subjects: Australian Ovarian Cancer Study Group, Cell Line, Tumor, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Genetic Predisposition to Disease, Homeodomain Proteins, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Protein Binding, Quantitative Trait Loci, Female, Nuchal Cord, Genetic Association Studies, Carcinoma, Ovarian Epithelial, Cell Line, Tumor, Neoplasms, Glandular and Epithelial, Gene Expression Regulation, Neoplastic, Carcinoma, Ovarian Epithelial, Rare Diseases, Prevention, Ovarian Cancer, Biotechnology, Human Genome, Cancer, Genetics, 2.1 Biological and endogenous factors
Abstract: Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10(-5)). For three cis-eQTL associations (P
Published: 2015

19. Genome-wide significant risk associations for mucinous ovarian carcinoma (vol 47, pg 888, 2015)

Author: Kelemen, Linda E, Lawrenson, Kate, Tyrer, Jonathan, Li, Qiyuan, Lee, Janet M, Seo, Ji-Heui, Phelan, Catherine M, Beesley, Jonathan, Chen, Xiaoqing, Spindler, Tassja J, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chen, Y Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Doerk, Thilo, du Bois, Andreas, Duerst, Matthias, Eccles, Diana, Easton, Douglas T, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Engelholm, Svend Aage, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moysich, Kirsten B, Narod, Steven A, and Nedergaard, Lotte
Subjects: Developmental Biology, Medical and Health Sciences, Biological Sciences
Published: 2015

20. Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci

Author: Coetzee, Simon G, Shen, Howard C, Hazelett, Dennis J, Lawrenson, Kate, Kuchenbaecker, Karoline, Tyrer, Jonathan, Rhie, Suhn K, Levanon, Keren, Karst, Alison, Drapkin, Ronny, Ramus, Susan J, Consortium, The Consortium of Investigators of Modifiers of BRCA1 2 The Ovarian Cancer Association, Couch, Fergus J, Offit, Kenneth, Chenevix-Trench, Georgia, Monteiro, Alvaro NA, Antoniou, Antonis, Freedman, Matthew, Coetzee, Gerhard A, Pharoah, Paul DP, Noushmehr, Houtan, Gayther, Simon A, Anton-Culver, Hoda, Antonenkova, Natalia, Baker, Helen, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Berchuck, Andrew, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chen, Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Easton, Douglas F, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Grownwald, Jacek, Harrington, Patricia, Harter, Philipp, Hasmad, Hanis Nazihah, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Estrid, Hogdall, Claus, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, James, Paul, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kjaer, Susanne Kruger, Kelemen, Linda E, Kellar, Melissa, Kelley, Joseph L, Kiemeney, Lambertus A, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, and Lissowska, Jolanta
Subjects: Biological Sciences, Genetics, Rare Diseases, Prevention, Human Genome, Ovarian Cancer, Biotechnology, Cancer, 2.1 Biological and endogenous factors, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, Chromatin, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Histones, Humans, Organ Specificity, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Regulatory Sequences, Nucleic Acid, Ovarian Cancer Association Consortium, The Consortium of Investigators of Modifiers of BRCA1/2, Ovarian Cancer Association Consortium The Consortium of Investigators of Modifiers of BRCA1/2, Medical and Health Sciences, Genetics & Heredity
Abstract: Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as functional targets of susceptibility variants. Here, we describe genome-wide annotation of regions of open chromatin and histone modification in fallopian tube and ovarian surface epithelial cells (FTSECs, OSECs), the debated cellular origins of high-grade serous ovarian cancers (HGSOCs) and in endometriosis epithelial cells (EECs), the likely precursor of clear cell ovarian carcinomas (CCOCs). The regulatory architecture of these cell types was compared with normal human mammary epithelial cells and LNCaP prostate cancer cells. We observed similar positional patterns of global enhancer signatures across the three different ovarian cancer precursor cell types, and evidence of tissue-specific regulatory signatures compared to non-gynecological cell types. We found significant enrichment for risk-associated SNPs intersecting regulatory biofeatures at 17 known HGSOC susceptibility loci in FTSECs (P = 3.8 × 10(-30)), OSECs (P = 2.4 × 10(-23)) and HMECs (P = 6.7 × 10(-15)) but not for EECs (P = 0.45) or LNCaP cells (P = 0.88). Hierarchical clustering of risk SNPs conditioned on the six different cell types indicates FTSECs and OSECs are highly related (96% of samples using multi-scale bootstrapping) suggesting both cell types may be precursors of HGSOC. These data represent the first description of regulatory catalogues of normal precursor cells for different ovarian cancer subtypes, and provide unique insights into the tissue specific regulatory variation with respect to the likely functional targets of germline genetic susceptibility variants for ovarian cancer.
Published: 2015

21. Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.

Author: Lee, Alice W, Tyrer, Jonathan P, Doherty, Jennifer A, Stram, Douglas A, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Plisiecka-Halasa, Joanna, Spiewankiewicz, Beata, Myers, Emily J, Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Hein, Alexander, Vergote, Ignace, Van Nieuwenhuysen, Els, Lambrechts, Diether, Wicklund, Kristine G, Eilber, Ursula, Wang-Gohrke, Shan, Chang-Claude, Jenny, Rudolph, Anja, Sucheston-Campbell, Lara, Odunsi, Kunle, Moysich, Kirsten B, Shvetsov, Yurii B, Thompson, Pamela J, Goodman, Marc T, Wilkens, Lynne R, Dörk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo B, Bogdanova, Natalia, Pelttari, Liisa M, Nevanlinna, Heli, Leminen, Arto, Edwards, Robert P, Kelley, Joseph L, Harter, Philipp, Schwaab, Ira, Heitz, Florian, du Bois, Andreas, Orsulic, Sandra, Lester, Jenny, Walsh, Christine, Karlan, Beth Y, Hogdall, Estrid, Kjaer, Susanne K, Jensen, Allan, Vierkant, Robert A, Cunningham, Julie M, Goode, Ellen L, Fridley, Brooke L, Southey, Melissa C, Giles, Graham G, Bruinsma, Fiona, Wu, Xifeng, Hildebrandt, Michelle AT, Lu, Karen, Liang, Dong, Bisogna, Maria, Levine, Douglas A, Weber, Rachel Palmieri, Schildkraut, Joellen M, Iversen, Edwin S, Berchuck, Andrew, Terry, Kathryn L, Cramer, Daniel W, Tworoger, Shelley S, Poole, Elizabeth M, Olson, Sara H, Orlow, Irene, Bandera, Elisa V, Bjorge, Line, Tangen, Ingvild L, Salvesen, Helga B, Krakstad, Camilla, Massuger, Leon FAG, Kiemeney, Lambertus A, Aben, Katja KH, van Altena, Anne M, Bean, Yukie, Pejovic, Tanja, Kellar, Melissa, Le, Nhu D, Cook, Linda S, Kelemen, Linda E, Brooks-Wilson, Angela, Lubinski, Jan, Gronwald, Jacek, Cybulski, Cezary, Jakubowska, Anna, Wentzensen, Nicolas, Brinton, Louise A, Lissowska, Jolanta, Yang, Hannah, and Nedergaard, Lotte
Subjects: Australian Cancer Study, Australian Ovarian Cancer Study Group, Humans, Ovarian Neoplasms, Genetic Predisposition to Disease, Gonadotropins, Genetic Markers, Logistic Models, Risk Factors, Case-Control Studies, Signal Transduction, Genotype, Polymorphism, Single Nucleotide, Female, Genome-Wide Association Study, Biomarkers, Tumor, Gene, Genetic variation, Genetics, Ovarian cancer, Polymorphisms, Polymorphism, Single Nucleotide, Biomarkers, Tumor, Ovarian Cancer, Aging, Prevention, Human Genome, Cancer, Biotechnology, Rare Diseases, 2.1 Biological and endogenous factors, Oncology & Carcinogenesis, Oncology and Carcinogenesis, Paediatrics and Reproductive Medicine
Abstract: ObjectiveOvarian cancer is a hormone-related disease with a strong genetic basis. However, none of its high-penetrance susceptibility genes and GWAS-identified variants to date are known to be involved in hormonal pathways. Given the hypothesized etiologic role of gonadotropins, an assessment of how variability in genes involved in the gonadotropin signaling pathway impacts disease risk is warranted.MethodsGenetic data from 41 ovarian cancer study sites were pooled and unconditional logistic regression was used to evaluate whether any of the 2185 SNPs from 11 gonadotropin signaling pathway genes was associated with ovarian cancer risk. A burden test using the admixture likelihood (AML) method was also used to evaluate gene-level associations.ResultsWe did not find any genome-wide significant associations between individual SNPs and ovarian cancer risk. However, there was some suggestion of gene-level associations for four gonadotropin signaling pathway genes: INHBB (p=0.045, mucinous), LHCGR (p=0.046, high-grade serous), GNRH (p=0.041, high-grade serous), and FSHB (p=0.036, overall invasive). There was also suggestive evidence for INHA (p=0.060, overall invasive).ConclusionsOvarian cancer studies have limited sample numbers, thus fewer genome-wide susceptibility alleles, with only modest associations, have been identified relative to breast and prostate cancers. We have evaluated the majority of ovarian cancer studies with biological samples, to our knowledge, leaving no opportunity for replication. Using both our understanding of biology and powerful gene-level tests, we have identified four putative ovarian cancer loci near INHBB, LHCGR, GNRH, and FSHB that warrant a second look if larger sample sizes and denser genotype chips become available.
Published: 2015

22. Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

Author: Chornokur, Ganna, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Amankwah, Ernest K, Qu, Xiaotao, Tsai, Ya-Yu, Jim, Heather SL, Chen, Zhihua, Chen, Ann Y, Permuth-Wey, Jennifer, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harrington, Patricia, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kelemen, Linda E, Kellar, Mellissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, and Orlow, Irene
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Cancer, Ovarian Cancer, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Black or African American, Alleles, Asian, Biological Transport, Carcinoma, Ovarian Epithelial, Carrier Proteins, Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Humans, Neoplasms, Glandular and Epithelial, Odds Ratio, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Risk, Georgia Chenevix-Trench, AOCS management group, General Science & Technology
Abstract: BackgroundDefective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk.MethodsIn total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q
Published: 2015

23. Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)

Author: Jim, Heather SL, Lin, Hui-Yi, Tyrer, Jonathan P, Lawrenson, Kate, Dennis, Joe, Chornokur, Ganna, Chen, Zhihua, Chen, Ann Y, Permuth-Wey, Jennifer, Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia, Bruinsma, Fiona, Bandera, Elisa V, Bean, Yukie T, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bunker, Clareann H, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, du Bois, Andreas, Despierre, Evelyn, Sieh, Weiva, Doherty, Jennifer A, Dörk, Thilo, Dürst, Matthias, Easton, Douglas F, Eccles, Diana M, Edwards, Robert P, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind, Goodman, Marc T, Gronwald, Jacek, Harter, Philipp, Hasmad, Hanis N, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle AT, Hillemanns, Peter, Hogdall, Claus K, Hogdall, Estrid, Hosono, Satoyo, Iversen, Edwin S, Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Karlan, Beth Y, Kellar, Melissa, Kiemeney, Lambertus A, Krakstad, Camilla, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Vierkant, Robert A, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Alice W, Lele, Shashi, Leminen, Arto, Lester, Jenny, Levine, Douglas A, Liang, Dong, Lim, Boon Kiong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon FAG, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R, McNeish, Ian, Menon, Usha, Milne, Roger L, Modugno, Francesmary, Thomsen, Lotte, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Eilber, Ursula, Odunsi, Kunle, Olson, Sara H, Orlow, Irene, and Orsulic, Sandra
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Health Services and Systems, Health Sciences, Oncology and Carcinogenesis, Cancer, Orphan Drug, Prevention, Sleep Research, Rare Diseases, Ovarian Cancer, Aetiology, 2.1 Biological and endogenous factors, Georgia Chenevix-Trench on behalf of the AOCS management group 95, 96
Abstract: Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and gliomas. Circadian genes are highly expressed in the ovaries where they regulate ovulation; circadian disruption is associated with several ovarian cancer risk factors (e.g., endometriosis). However, no studies have examined variation in germline circadian genes as predictors of ovarian cancer risk and invasiveness. The goal of the current study was to examine single nucleotide polymorphisms (SNPs) in circadian genes BMAL1, CRY2, CSNK1E, NPAS2, PER3, REV1 and TIMELESS and downstream transcription factors KLF10 and SENP3 as predictors of risk of epithelial ovarian cancer (EOC) and histopathologic subtypes. The study included a test set of 3,761 EOC cases and 2,722 controls and a validation set of 44,308 samples including 18,174 (10,316 serous) cases and 26,134 controls from 43 studies participating in the Ovarian Cancer Association Consortium (OCAC). Analysis of genotype data from 36 genotyped SNPs and 4600 imputed SNPs indicated that the most significant association was rs117104877 in BMAL1 (OR = 0.79, 95% CI = 0.68-0.90, p = 5.59 × 10-4]. Functional analysis revealed a significant down regulation of BMAL1 expression following cMYC overexpression and increasing transformation in ovarian surface epithelial (OSE) cells as well as alternative splicing of BMAL1 exons in ovarian and granulosa cells. These results suggest that variation in circadian genes, and specifically BMAL1, may be associated with risk of ovarian cancer, likely through disruption of hormonal pathways.
Published: 2015

24. Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.

Author: Kelemen, Linda E, Terry, Kathryn L, Goodman, Marc T, Webb, Penelope M, Bandera, Elisa V, McGuire, Valerie, Rossing, Mary Anne, Wang, Qinggang, Dicks, Ed, Tyrer, Jonathan P, Song, Honglin, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Plisiecka-Halasa, Joanna, Timorek, Agnieszka, Menon, Usha, Gentry-Maharaj, Aleksandra, Gayther, Simon A, Ramus, Susan J, Narod, Steven A, Risch, Harvey A, McLaughlin, John R, Siddiqui, Nadeem, Glasspool, Rosalind, Paul, James, Carty, Karen, Gronwald, Jacek, Lubiński, Jan, Jakubowska, Anna, Cybulski, Cezary, Kiemeney, Lambertus A, Massuger, Leon FAG, van Altena, Anne M, Aben, Katja KH, Olson, Sara H, Orlow, Irene, Cramer, Daniel W, Levine, Douglas A, Bisogna, Maria, Giles, Graham G, Southey, Melissa C, Bruinsma, Fiona, Kjaer, Susanne K, Høgdall, Estrid, Jensen, Allan, Høgdall, Claus K, Lundvall, Lene, Engelholm, Svend-Aage, Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M, Leminen, Arto, Thompson, Pamela J, Lurie, Galina, Wilkens, Lynne R, Lambrechts, Diether, Van Nieuwenhuysen, Els, Lambrechts, Sandrina, Vergote, Ignace, Beesley, Jonathan, AOCS Study Group/ACS Investigators, Fasching, Peter A, Beckmann, Matthias W, Hein, Alexander, Ekici, Arif B, Doherty, Jennifer A, Wu, Anna H, Pearce, Celeste L, Pike, Malcolm C, Stram, Daniel, Chang-Claude, Jenny, Rudolph, Anja, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo B, Bogdanova, Natalia, Antonenkova, Natalia, Odunsi, Kunle, Edwards, Robert P, Kelley, Joseph L, Modugno, Francesmary, Ness, Roberta B, Karlan, Beth Y, Walsh, Christine, Lester, Jenny, Orsulic, Sandra, Fridley, Brooke L, Vierkant, Robert A, Cunningham, Julie M, Wu, Xifeng, Lu, Karen, Liang, Dong, Hildebrandt, Michelle AT, Weber, Rachel Palmieri, and Iversen, Edwin S
Subjects: AOCS Study Group/ACS Investigators, Humans, Carcinoma, Ovarian Neoplasms, Folic Acid Deficiency, Genetic Predisposition to Disease, Folic Acid, Dihydrouracil Dehydrogenase (NADP), Neoplasm Proteins, Diet, Multivariate Analysis, Risk Factors, Case-Control Studies, Energy Intake, Polymorphism, Single Nucleotide, Dietary Supplements, European Continental Ancestry Group, Female, Genome-Wide Association Study, Global Health, Case-control, Dihydropyrimidine dehydrogenase, Folate, Polymorphism, Serine hydroxymethyltransferase 1, Rare Diseases, Cancer, Ovarian Cancer, Genetics, Nutrition, 2.1 Biological and endogenous factors, Nutrition & Dietetics, Food Science, Food Sciences, Nutrition and Dietetics, Public Health and Health Services
Abstract: ScopeWe reevaluated previously reported associations between variants in pathways of one-carbon (1-C) (folate) transfer genes and ovarian carcinoma (OC) risk, and in related pathways of purine and pyrimidine metabolism, and assessed interactions with folate intake.Methods and resultsOdds ratios (OR) for 446 genetic variants were estimated among 13,410 OC cases and 22,635 controls, and among 2281 cases and 3444 controls with folate information. Following multiple testing correction, the most significant main effect associations were for dihydropyrimidine dehydrogenase (DPYD) variants rs11587873 (OR = 0.92; p = 6 × 10⁻⁵) and rs828054 (OR = 1.06; p = 1 × 10⁻⁴). Thirteen variants in the pyrimidine metabolism genes, DPYD, DPYS, PPAT, and TYMS, also interacted significantly with folate in a multivariant analysis (corrected p = 9.9 × 10⁻⁶) but collectively explained only 0.2% of OC risk. Although no other associations were significant after multiple testing correction, variants in SHMT1 in 1-C transfer, previously reported with OC, suggested lower risk at higher folate (p(interaction) = 0.03-0.006).ConclusionVariation in pyrimidine metabolism genes, particularly DPYD, which was previously reported to be associated with OC, may influence risk; however, stratification by folate intake is unlikely to modify disease risk appreciably in these women. SHMT1 SNP-by-folate interactions are plausible but require further validation. Polymorphisms in selected genes in purine metabolism were not associated with OC.
Published: 2014

25. Variation in NF-κB Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer

Author: Block, Matthew S, Charbonneau, Bridget, Vierkant, Robert A, Fogarty, Zachary, Bamlet, William R, Pharoah, Paul DP, Chenevix-Trench, Georgia, AOCS, for, Group, ACS, Rossing, Mary Anne, Cramer, Daniel, Pearce, Celeste Leigh, Schildkraut, Joellen, Menon, Usha, Kjaer, Susanne K, Levine, Douglas A, Gronwald, Jacek, Culver, Hoda Anton, Whittemore, Alice S, Karlan, Beth Y, Lambrechts, Diether, Wentzensen, Nicolas, Kupryjanczyk, Jolanta, Chang-Claude, Jenny, Bandera, Elisa V, Hogdall, Estrid, Heitz, Florian, Kaye, Stanley B, Fasching, Peter A, Campbell, Ian, Goodman, Marc T, Pejovic, Tanja, Bean, Yukie T, Hays, Laura E, Lurie, Galina, Eccles, Diana, Hein, Alexander, Beckmann, Matthias W, Ekici, Arif B, Paul, James, Brown, Robert, Flanagan, James M, Harter, Philipp, du Bois, Andreas, Schwaab, Ira, Hogdall, Claus K, Lundvall, Lene, Olson, Sara H, Orlow, Irene, Paddock, Lisa E, Rudolph, Anja, Eilber, Ursula, Dansonka-Mieszkowska, Agnieszka, Rzepecka, Iwona K, Ziolkowska-Seta, Izabela, Brinton, Louise A, Yang, Hannah, Garcia-Closas, Montserrat, Despierre, Evelyn, Lambrechts, Sandrina, Vergote, Ignace, Walsh, Christine S, Lester, Jenny, Sieh, Weiva, McGuire, Valerie, Rothstein, Joseph H, Ziogas, Argyrios, Lubiński, Jan, Cybulski, Cezary, Menkiszak, Janusz, Jensen, Allan, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Berchuck, Andrew, Wu, Anna H, Pike, Malcolm C, Van Den Berg, David, Terry, Kathryn L, Vitonis, Allison F, Ramirez, Starr M, Rider, David N, Knutson, Keith L, Sellers, Thomas A, Phelan, Catherine M, Doherty, Jennifer A, Johnatty, Sharon E, deFazio, Anna, Song, Honglin, Tyrer, Jonathan, Kalli, Kimberly R, Fridley, Brooke L, Cunningham, Julie M, and Goode, Ellen L
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Prevention, Ovarian Cancer, Genetics, Rare Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Adult, Aged, Carcinoma, Ovarian Epithelial, Female, Genotype, Humans, Middle Aged, NF-kappa B, Neoplasm Invasiveness, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Proportional Hazards Models, Signal Transduction, Georgia Chenevix-Trench, for AOCS, /ACS Group, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract: Survival in epithelial ovarian cancer (EOC) is influenced by the host immune response, yet the key genetic determinants of inflammation and immunity that affect prognosis are not known. The nuclear factor-κB (NF-κB) transcription factor family plays an important role in many immune and inflammatory responses, including the response to cancer. We studied common inherited variation in 210 genes in the NF-κB family in 10,084 patients with invasive EOC (5,248 high-grade serous, 1,452 endometrioid, 795 clear cell, and 661 mucinous) from the Ovarian Cancer Association Consortium. Associations between genotype and overall survival were assessed using Cox regression for all patients and by major histology, adjusting for known prognostic factors and correcting for multiple testing (threshold for statistical significance, P < 2.5 × 10(-5)). Results were statistically significant when assessed for patients of a single histology. Key associations were with caspase recruitment domain family, member 11 (CARD11) rs41324349 in patients with mucinous EOC [HR, 1.82; 95% confidence interval (CI), 1.41-2.35; P = 4.13 × 10(-6)] and tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) rs7501462 in patients with endometrioid EOC (HR, 0.68; 95% CI, 0.56-0.82; P = 2.33 × 10(-5)). Other associations of note included TNF receptor-associated factor 2 (TRAF2) rs17250239 in patients with high-grade serous EOC (HR, 0.84; 95% CI, 0.77-0.92; P = 6.49 × 10(-5)) and phospholipase C, gamma 1 (PLCG1) rs11696662 in patients with clear cell EOC (HR, 0.43; 95% CI, 0.26-0.73; P = 4.56 × 10(-4)). These associations highlight the potential importance of genes associated with host inflammation and immunity in modulating clinical outcomes in distinct EOC histologies.
Published: 2014

26. Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

Author: Walsh, Christine, Lester, Jenny, Jensen, Allan, Kjær, Susanne, Høgdall, Claus, Høgdall, Estrid, Lundvall, Lene, Sellers, Thomas, Fridley, Brooke, Goode, Ellen, Cunningham, Julie, Vierkant, Robert, Giles, Graham, Baglietto, Laura, Severi, Gianluca, Southey, Melissa, Liang, Dong, Wu, Xifeng, Lu, Karen, Hildebrandt, Michelle, Levine, Douglas, Bisogna, Maria, Schildkraut, Joellen, Iversen, Edwin, Weber, Rachel, Berchuck, Andrew, Cramer, Daniel, Terry, Kathryn, Poole, Elizabeth, Tworoger, Shelley, Bandera, Elisa, Chandran, Urmila, Orlow, Irene, Olson, Sara, Wik, Elisabeth, Salvesen, Helga, Bjorge, Line, Halle, Mari, van Altena, Anne, Aben, Katja, Kiemeney, Lambertus, Massuger, Leon, Pejovic, Tanja, Bean, Yukie, Cybulski, Cezary, Gronwald, Jacek, Lubinski, Jan, Wentzensen, Nicolas, Brinton, Louise, Lissowska, Jolanta, Garcia-Closas, Montserrat, Dicks, Ed, Dennis, Joe, Easton, Douglas, Song, Honglin, Tyrer, Jonathan, Pharoah, Paul, Eccles, Diana, Campbell, Ian, Whittemore, Alice, McGuire, Valerie, Sieh, Weiva, Rothstein, Joseph, Flanagan, James, Paul, James, Brown, Robert, Phelan, Catherine, Risch, Harvey, McLaughlin, John, Narod, Steven, Ziogas, Argyrios, Anton-Culver, Hoda, Gentry-Maharaj, Aleksandra, Menon, Usha, Gayther, Simon, Ramus, Susan, Wu, Anna, Pearce, Celeste, Pike, Malcolm, Dansonka-Mieszkowska, Agnieszka, Rzepecka, Iwona, Szafron, Lukasz, Kupryjanczyk, Jolanta, Cook, Linda, Le, Nhu, Brooks-Wilson, Angela, Earp, Madalene, Kelemen, Linda, Magliocco, Anthony, Swenerton, Kenneth, Chenevix-Trench, Georgia, Lu, Yi, Hein, Alexander, Ekici, Arif, Beckmann, Matthias, Fasching, Peter, Lambrechts, Diether, Despierre, Evelyn, Vergote, Ignace, and Lambrechts, Sandrina
Subjects: Alleles, Carcinoma, Ovarian Epithelial, DNA, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Quality Control
Abstract: Epithelial ovarian cancer (EOC) is a heterogeneous cancer with both genetic and environmental risk factors. Variants influencing the risk of developing the less-common EOC subtypes have not been fully investigated. We performed a genome-wide association study (GWAS) of EOC according to subtype by pooling genomic DNA from 545 cases and 398 controls of European descent, and testing for allelic associations. We evaluated for replication 188 variants from the GWAS [56 variants for mucinous, 55 for endometrioid and clear cell, 53 for low-malignant potential (LMP) serous, and 24 for invasive serous EOC], selected using pre-defined criteria. Genotypes from 13,188 cases and 23,164 controls of European descent were used to perform unconditional logistic regression under the log-additive genetic model; odds ratios (OR) and 95 % confidence intervals are reported. Nine variants tagging six loci were associated with subtype-specific EOC risk at P
Published: 2014

27. Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

Author: Charbonneau, Bridget, Moysich, Kirsten B, Kalli, Kimberly R, Oberg, Ann L, Vierkant, Robert A, Fogarty, Zachary C, Block, Matthew S, Maurer, Matthew J, Goergen, Krista M, Fridley, Brooke L, Cunningham, Julie M, Rider, David N, Preston, Claudia, Hartmann, Lynn C, Lawrenson, Kate, Wang, Chen, Tyrer, Jonathan, Song, Honglin, deFazio, Anna, Johnatty, Sharon E, Doherty, Jennifer A, Phelan, Catherine M, Sellers, Thomas A, Ramirez, Starr M, Vitonis, Allison F, Terry, Kathryn L, Van Den Berg, David, Pike, Malcolm C, Wu, Anna H, Berchuck, Andrew, Gentry-Maharaj, Aleksandra, Ramus, Susan J, Diergaarde, Brenda, Shen, Howard, Jensen, Allan, Menkiszak, Janusz, Cybulski, Cezary, Lubiński, Jan, Ziogas, Argyrios, Rothstein, Joseph H, McGuire, Valerie, Sieh, Weiva, Lester, Jenny, Walsh, Christine, Vergote, Ignace, Lambrechts, Sandrina, Despierre, Evelyn, Garcia-Closas, Montserrat, Yang, Hannah, Brinton, Louise A, Spiewankiewicz, Beata, Rzepecka, Iwona K, Dansonka-Mieszkowska, Agnieszka, Seibold, Petra, Rudolph, Anja, Paddock, Lisa E, Orlow, Irene, Lundvall, Lene, Olson, Sara H, Hogdall, Claus K, Schwaab, Ira, du Bois, Andreas, Harter, Philipp, Flanagan, James M, Brown, Robert, Paul, James, Ekici, Arif B, Beckmann, Matthias W, Hein, Alexander, Eccles, Diana, Lurie, Galina, Hays, Laura E, Bean, Yukie T, Pejovic, Tanja, Goodman, Marc T, Campbell, Ian, Fasching, Peter A, Konecny, Gottfried, Kaye, Stanley B, Heitz, Florian, Hogdall, Estrid, Bandera, Elisa V, Chang-Claude, Jenny, Kupryjanczyk, Jolanta, Wentzensen, Nicolas, Lambrechts, Diether, Karlan, Beth Y, Whittemore, Alice S, Culver, Hoda Anton, Gronwald, Jacek, Levine, Douglas A, Kjaer, Susanne K, Menon, Usha, Schildkraut, Joellen M, Pearce, Celeste Leigh, Cramer, Daniel W, Rossing, Mary Anne, Chenevix-Trench, Georgia, group, for the AOCS, and ACS
Subjects: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Genetics, Clinical Research, Ovarian Cancer, Rare Diseases, Women's Health, 2.1 Biological and endogenous factors, Female, Gene Expression, Gene Expression Profiling, Genetic Predisposition to Disease, Genetic Variation, Germ-Line Mutation, Humans, Interleukin-2 Receptor alpha Subunit, Neoplasm Grading, Neoplasm Invasiveness, Ovarian Neoplasms, Patient Outcome Assessment, Polymorphism, Single Nucleotide, Prognosis, T-Lymphocytes, Regulatory, AOCS group, ACS, Pharmacology and Pharmaceutical Sciences, Oncology and carcinogenesis
Abstract: The presence of regulatory T cells (Treg) in solid tumors is known to play a role in patient survival in ovarian cancer and other malignancies. We assessed inherited genetic variations via 749 tag single-nucleotide polymorphisms (SNP) in 25 Treg-associated genes (CD28, CTLA4, FOXP3, IDO1, IL10, IL10RA, IL15, 1L17RA, IL23A, IL23R, IL2RA, IL6, IL6R, IL8, LGALS1, LGALS9, MAP3K8, STAT5A, STAT5B, TGFB1, TGFB2, TGFB3, TGFBR1, TGRBR2, and TGFBR3) in relation to ovarian cancer survival. We analyzed genotype and overall survival in 10,084 women with invasive epithelial ovarian cancer, including 5,248 high-grade serous, 1,452 endometrioid, 795 clear cell, and 661 mucinous carcinoma cases of European descent across 28 studies from the Ovarian Cancer Association Consortium (OCAC). The strongest associations were found for endometrioid carcinoma and IL2RA SNPs rs11256497 [HR, 1.42; 95% confidence interval (CI), 1.22-1.64; P = 5.7 × 10(-6)], rs791587 (HR, 1.36; 95% CI, 1.17-1.57; P = 6.2 × 10(-5)), rs2476491 (HR, = 1.40; 95% CI, 1.19-1.64; P = 5.6 × 10(-5)), and rs10795763 (HR, 1.35; 95% CI, 1.17-1.57; P = 7.9 × 10(-5)), and for clear cell carcinoma and CTLA4 SNP rs231775 (HR, 0.67; 95% CI, 0.54-0.82; P = 9.3 × 10(-5)) after adjustment for age, study site, population stratification, stage, grade, and oral contraceptive use. The rs231775 allele associated with improved survival in our study also results in an amino acid change in CTLA4 and previously has been reported to be associated with autoimmune conditions. Thus, we found evidence that SNPs in genes related to Tregs seem to play a role in ovarian cancer survival, particularly in patients with clear cell and endometrioid epithelial ovarian cancer.
Published: 2014

28. Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10.

Author: Charbonneau, Bridget, Block, Matthew, Bamlet, William, Vierkant, Robert, Kalli, Kimberly, Fogarty, Zachary, Rider, David, Sellers, Thomas, Tworoger, Shelley, Poole, Elizabeth, Risch, Harvey, Salvesen, Helga, Kiemeney, Lambertus, Baglietto, Laura, Giles, Graham, Severi, Gianluca, Trabert, Britton, Wentzensen, Nicolas, Chenevix-Trench, Georgia, Whittemore, Alice, Sieh, Weiva, Chang-Claude, Jenny, Bandera, Elisa, Orlow, Irene, Terry, Kathryn, Goodman, Marc, Thompson, Pamela, Cook, Linda, Rossing, Mary, Ness, Roberta, Narod, Steven, Kupryjanczyk, Jolanta, Lu, Karen, Butzow, Ralf, Dörk, Thilo, Pejovic, Tanja, Campbell, Ian, Le, Nhu, Bunker, Clareann, Bogdanova, Natalia, Runnebaum, Ingo, Eccles, Diana, Paul, James, Wu, Anna, Gayther, Simon, Hogdall, Estrid, Heitz, Florian, Kaye, Stanley, Walsh, Christine, Despierre, Evelyn, Brinton, Louise, Hein, Alexander, Rudolph, Anja, Dansonka-Mieszkowska, Agnieszka, Olson, Sara, Harter, Philipp, Tyrer, Jonathan, Vitonis, Allison, Brooks-Wilson, Angela, Aben, Katja, Pike, Malcolm, Ramus, Susan, Wik, Elisabeth, Cybulski, Cezary, Lin, Jie, Sucheston, Lara, Edwards, Robert, McGuire, Valerie, Lester, Jenny, du Bois, Andreas, Lundvall, Lene, Wang-Gohrke, Shan, Szafron, Lukasz, Lambrechts, Sandrina, Yang, Hannah, Beckmann, Matthias, Pelttari, Liisa, Van Altena, Anne, van den Berg, David, Halle, Mari, Gentry-Maharaj, Aleksandra, Schwaab, Ira, Chandran, Urmila, Menkiszak, Janusz, Ekici, Arif, Wilkens, Lynne, Leminen, Arto, Modugno, Francesmary, Friel, Grace, Rothstein, Joseph, Vergote, Ignace, Garcia-Closas, Montserrat, Hildebrandt, Michelle, Sobiczewski, Piotr, Kelemen, Linda, Pharoah, Paul, Moysich, Kirsten, Knutson, Keith, Cunningham, Julie, and Fridley, Brooke
Subjects: Case-Control Studies, Female, Genetic Association Studies, Humans, Interleukin-1alpha, NF-kappa B, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Risk, Signal Transduction, TNF-Related Apoptosis-Inducing Ligand
Abstract: A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly understood, rs17561 has also been associated with risk of endometriosis, an epidemiologic risk factor for ovarian cancer. Interleukin-1α (IL1A) is both regulated by and able to activate NF-κB, a transcription factor family that induces transcription of many proinflammatory genes and may be an important mediator in carcinogenesis. We therefore tagged SNPs in more than 200 genes in the NF-κB pathway for a total of 2,282 SNPs (including rs17561) for genotype analysis of 15,604 cases of ovarian cancer in patients of European descent, including 6,179 of high-grade serous (HGS), 2,100 endometrioid, 1,591 mucinous, 1,034 clear cell, and 1,016 low-grade serous, including 23,235 control cases spanning 40 studies in the Ovarian Cancer Association Consortium. In this large population, we confirmed the association between rs17561 and clear cell ovarian cancer [OR, 0.84; 95% confidence interval (CI), 0.76-0.93; P = 0.00075], which remained intact even after excluding participants in the prior study (OR, 0.85; 95% CI, 0.75-0.95; P = 0.006). Considering a multiple-testing-corrected significance threshold of P < 2.5 × 10(-5), only one other variant, the TNFSF10 SNP rs6785617, was associated significantly with a risk of ovarian cancer (low malignant potential tumors OR, 0.85; 95% CI, 0.79-0.91; P = 0.00002). Our results extend the evidence that borderline tumors may have a distinct genetic etiology. Further investigation of how these SNPs might modify ovarian cancer associations with other inflammation-related risk factors is warranted.
Published: 2014

29. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

Author: Antonenkova, Natalia, Armasu, Sebastian, Baglietto, Laura, Bandera, Elisa, Beckmann, Matthias, Birrer, Michael, Bloom, Greg, Bogdanova, Natalia, Brenton, James, Brinton, Louise, Brooks-Wilson, Angela, Brown, Robert, Butzow, Ralf, Campbell, Ian, Carney, Michael, Carvalho, Renato, Chang-Claude, Jenny, Chen, Y, Chen, Zhihua, Chow, Wong-Ho, Cicek, Mine, Coetzee, Gerhard, Cook, Linda, Cramer, Daniel, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Edwards, Robert, Ekici, Arif, Fasching, Peter, Fenstermacher, David, Flanagan, James, Gao, Yu-Tang, Garcia-Closas, Montserrat, Gentry-Maharaj, Aleksandra, Giles, Graham, Gjyshi, Anxhela, Gore, Martin, Gronwald, Jacek, Guo, Qi, Halle, Mari, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hillemanns, Peter, Hoatlin, Maureen, Høgdall, Estrid, Høgdall, Claus, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Kalli, Kimberly, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu, Lee, Nathan, Lee, Janet, Leminen, Arto, Lim, Boon, Lissowska, Jolanta, Lubiński, Jan, Lundvall, Lene, Lurie, Galina, Massuger, Leon, Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John, Menon, Usha, Modugno, Francesmary, Moysich, Kirsten, Nakanishi, Toru, Narod, Steven, Ness, Roberta, Nevanlinna, Heli, Nickels, Stefan, Noushmehr, Houtan, Odunsi, Kunle, Olson, Sara, Orlow, Irene, Paul, James, Pejovic, Tanja, Pelttari, Liisa, Permuth-Wey, Jenny, Pike, Malcolm, Poole, Elizabeth, Qu, Xiaotao, Risch, Harvey, Rodriguez-Rodriguez, Lorna, Rossing, Mary, Rudolph, Anja, Runnebaum, Ingo, Rzepecka, Iwona, and Salvesen, Helga
Subjects: Case-Control Studies, Cooperative Behavior, Cystadenocarcinoma, Serous, Female, Gene-Environment Interaction, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Meta-Analysis as Topic, Neoplasm Invasiveness, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Risk Factors
Abstract: Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10(-9)) and 10p12 (rs1243180, P = 1.8 × 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
Published: 2013

30. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

Author: Pharoah, Paul DP, Tsai, Ya-Yu, Ramus, Susan J, Phelan, Catherine M, Goode, Ellen L, Lawrenson, Kate, Buckley, Melissa, Fridley, Brooke L, Tyrer, Jonathan P, Shen, Howard, Weber, Rachel, Karevan, Rod, Larson, Melissa C, Song, Honglin, Tessier, Daniel C, Bacot, François, Vincent, Daniel, Cunningham, Julie M, Dennis, Joe, Dicks, Ed, Australian Cancer Study, Australian Ovarian Cancer Study Group, Aben, Katja K, Anton-Culver, Hoda, Antonenkova, Natalia, Armasu, Sebastian M, Baglietto, Laura, Bandera, Elisa V, Beckmann, Matthias W, Birrer, Michael J, Bloom, Greg, Bogdanova, Natalia, Brenton, James D, Brinton, Louise A, Brooks-Wilson, Angela, Brown, Robert, Butzow, Ralf, Campbell, Ian, Carney, Michael E, Carvalho, Renato S, Chang-Claude, Jenny, Chen, Y Anne, Chen, Zhihua, Chow, Wong-Ho, Cicek, Mine S, Coetzee, Gerhard, Cook, Linda S, Cramer, Daniel W, Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Eccles, Diana, Edwards, Robert, Ekici, Arif B, Fasching, Peter A, Fenstermacher, David, Flanagan, James, Gao, Yu-Tang, Garcia-Closas, Montserrat, Gentry-Maharaj, Aleksandra, Giles, Graham, Gjyshi, Anxhela, Gore, Martin, Gronwald, Jacek, Guo, Qi, Halle, Mari K, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hillemanns, Peter, Hoatlin, Maureen, Høgdall, Estrid, Høgdall, Claus K, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Kalli, Kimberly R, Karlan, Beth Y, Kelemen, Linda E, Kiemeney, Lambertus A, Kjaer, Susanne Krüger, Konecny, Gottfried E, Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D, Lee, Nathan, Lee, Janet, Leminen, Arto, Lim, Boon Kiong, Lissowska, Jolanta, Lubiński, Jan, Lundvall, Lene, Lurie, Galina, and Massuger, Leon FAG
Subjects: Australian Cancer Study, Australian Ovarian Cancer Study Group, Humans, Cystadenocarcinoma, Serous, Ovarian Neoplasms, Neoplasm Invasiveness, Genetic Predisposition to Disease, Risk Factors, Case-Control Studies, Cooperative Behavior, Genotype, Polymorphism, Single Nucleotide, Female, Meta-Analysis as Topic, Genome-Wide Association Study, Genetic Loci, Gene-Environment Interaction, Cancer, Human Genome, Prevention, Genetics, Rare Diseases, Ovarian Cancer, Aetiology, 2.1 Biological and endogenous factors, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract: Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10(-9)) and 10p12 (rs1243180, P = 1.8 × 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
Published: 2013

31. Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

Author: Permuth-Wey, Jennifer, Lawrenson, Kate, Shen, Howard C, Velkova, Aneliya, Tyrer, Jonathan P, Chen, Zhihua, Lin, Hui-Yi, Ann Chen, Y, Tsai, Ya-Yu, Qu, Xiaotao, Ramus, Susan J, Karevan, Rod, Lee, Janet, Lee, Nathan, Larson, Melissa C, Aben, Katja K, Anton-Culver, Hoda, Antonenkova, Natalia, Antoniou, Antonis C, Armasu, Sebastian M, Bacot, François, Baglietto, Laura, Bandera, Elisa V, Barnholtz-Sloan, Jill, Beckmann, Matthias W, Birrer, Michael J, Bloom, Greg, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Brown, Robert, Butzow, Ralf, Cai, Qiuyin, Campbell, Ian, Chang-Claude, Jenny, Chanock, Stephen, Chenevix-Trench, Georgia, Cheng, Jin Q, Cicek, Mine S, Coetzee, Gerhard A, Cook, Linda S, Couch, Fergus J, Cramer, Daniel W, Cunningham, Julie M, Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Easton, Douglas F, Eccles, Diana, Edwards, Robert, Ekici, Arif B, Fasching, Peter A, Fenstermacher, David A, Flanagan, James M, Garcia-Closas, Montserrat, Gentry-Maharaj, Aleksandra, Giles, Graham G, Glasspool, Rosalind M, Gonzalez-Bosquet, Jesus, Goodman, Marc T, Gore, Martin, Górski, Bohdan, Gronwald, Jacek, Hall, Per, Halle, Mari K, Harter, Philipp, Heitz, Florian, Hillemanns, Peter, Hoatlin, Maureen, Høgdall, Claus K, Høgdall, Estrid, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Jim, Heather, Kalli, Kimberly R, Karlan, Beth Y, Kaye, Stanley B, Kelemen, Linda E, Kiemeney, Lambertus A, Kikkawa, Fumitaka, Konecny, Gottfried E, Krakstad, Camilla, Krüger Kjaer, Susanne, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Lancaster, Johnathan M, Le, Nhu D, Leminen, Arto, Levine, Douglas A, Liang, Dong, Kiong Lim, Boon, Lin, Jie, Lissowska, Jolanta, Lu, Karen H, and Lubiński, Jan
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Rare Diseases, Biotechnology, Ovarian Cancer, Cancer, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Carcinoma, Ovarian Epithelial, Chromosomes, Human, Pair 17, Female, Genetic Predisposition to Disease, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Australian Cancer Study, Australian Ovarian Cancer Study, Consortium of Investigators of Modifiers of BRCA1/2
Abstract: Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10(-8)) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10(-10)). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes.
Published: 2013

32. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Author: Dixon-Suen, Suzanne C., Nagle, Christina M., Thrift, Aaron P., Pharoah, Paul D. P., Ewing, Ailith, Pearce, Celeste Leigh, Zheng, Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A., Beckmann, Matthias W., Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A., Wicklund, Kristine G., Chang-Claude, Jenny, Jung, Audrey Y., Moysich, Kirsten B., Odunsi, Kunle, Goodman, Marc T., Wilkens, Lynne R., Thompson, Pamela J., Shvetsov, Yurii B., Dörk, Thilo, Park-Simon, Tjoung-Won, Hillemanns, Peter, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M., Leminen, Arto, Modugno, Francesmary, Ness, Roberta B., Edwards, Robert P., Kelley, Joseph L., Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Karlan, Beth Y., Lester, Jenny, Orsulic, Sandra, Rimel, Bobbie J., Kjær, Susanne K., Høgdall, Estrid, Jensen, Allan, Goode, Ellen L., Fridley, Brooke L., Cunningham, Julie M., Winham, Stacey J., Giles, Graham G., Bruinsma, Fiona, Milne, Roger L., Southey, Melissa C., Hildebrandt, Michelle A. T., Wu, Xifeng, Lu, Karen H., Liang, Dong, Levine, Douglas A., Bisogna, Maria, Schildkraut, Joellen M., Berchuck, Andrew, Cramer, Daniel W., Terry, Kathryn L., Bandera, Elisa V., Olson, Sara H., Salvesen, Helga B., Thomsen, Liv Cecilie Vestrheim, Kopperud, Reidun K., Bjorge, Line, Kiemeney, Lambertus A., Massuger, Leon F. A. G., Pejovic, Tanja, Bruegl, Amanda, Cook, Linda S., Le, Nhu D., Swenerton, Kenneth D., Brooks-Wilson, Angela, Kelemen, Linda E., Lubiński, Jan, Huzarski, Tomasz, Gronwald, Jacek, Menkiszak, Janusz, Wentzensen, Nicolas, Brinton, Louise, Yang, Hannah, Lissowska, Jolanta, Høgdall, Claus K., Lundvall, Lene, Song, Honglin, Tyrer, Jonathan P., Campbell, Ian, Eccles, Diana, Paul, James, Glasspool, Rosalind, Siddiqui, Nadeem, Whittemore, Alice S., Sieh, Weiva, McGuire, Valerie, Rothstein, Joseph H., Narod, Steven A., Phelan, Catherine, Risch, Harvey A., McLaughlin, John R., Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A., Ramus, Susan J., Gentry-Maharaj, Aleksandra, Wu, Anna H., Pike, Malcolm C., Tseng, Chiu-Chen, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Budzilowska, Agnieszka, Rzepecka, Iwona K., Webb, Penelope M., and on behalf of the Ovarian Cancer Association Consortium
Published: 2018
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33. Data from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

Author: Charbonneau, Bridget, primary, Moysich, Kirsten B., primary, Kalli, Kimberly R., primary, Oberg, Ann L., primary, Vierkant, Robert A., primary, Fogarty, Zachary C., primary, Block, Matthew S., primary, Maurer, Matthew J., primary, Goergen, Krista M., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, Rider, David N., primary, Preston, Claudia, primary, Hartmann, Lynn C., primary, Lawrenson, Kate, primary, Wang, Chen, primary, Tyrer, Jonathan, primary, Song, Honglin, primary, deFazio, Anna, primary, Johnatty, Sharon E., primary, Doherty, Jennifer A., primary, Phelan, Catherine M., primary, Sellers, Thomas A., primary, Ramirez, Starr M., primary, Vitonis, Allison F., primary, Terry, Kathryn L., primary, Van Den Berg, David, primary, Pike, Malcolm C., primary, Wu, Anna H., primary, Berchuck, Andrew, primary, Gentry-Maharaj, Aleksandra, primary, Ramus, Susan J., primary, Diergaarde, Brenda, primary, Shen, Howard, primary, Jensen, Allan, primary, Menkiszak, Janusz, primary, Cybulski, Cezary, primary, Lubiński, Jan, primary, Ziogas, Argyrios, primary, Rothstein, Joseph H., primary, McGuire, Valerie, primary, Sieh, Weiva, primary, Lester, Jenny, primary, Walsh, Christine, primary, Vergote, Ignace, primary, Lambrechts, Sandrina, primary, Despierre, Evelyn, primary, Garcia-Closas, Montserrat, primary, Yang, Hannah, primary, Brinton, Louise A., primary, Spiewankiewicz, Beata, primary, Rzepecka, Iwona K., primary, Dansonka-Mieszkowska, Agnieszka, primary, Seibold, Petra, primary, Rudolph, Anja, primary, Paddock, Lisa E., primary, Orlow, Irene, primary, Lundvall, Lene, primary, Olson, Sara H., primary, Hogdall, Claus K., primary, Schwaab, Ira, primary, du Bois, Andreas, primary, Harter, Philipp, primary, Flanagan, James M., primary, Brown, Robert, primary, Paul, James, primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Hein, Alexander, primary, Eccles, Diana, primary, Lurie, Galina, primary, Hays, Laura E., primary, Bean, Yukie T., primary, Pejovic, Tanja, primary, Goodman, Marc T., primary, Campbell, Ian, primary, Fasching, Peter A., primary, Konecny, Gottfried, primary, Kaye, Stanley B., primary, Heitz, Florian, primary, Hogdall, Estrid, primary, Bandera, Elisa V., primary, Chang-Claude, Jenny, primary, Kupryjanczyk, Jolanta, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Karlan, Beth Y., primary, Whittemore, Alice S., primary, Culver, Hoda Anton, primary, Gronwald, Jacek, primary, Levine, Douglas A., primary, Kjaer, Susanne K., primary, Menon, Usha, primary, Schildkraut, Joellen M., primary, Pearce, Celeste Leigh, primary, Cramer, Daniel W., primary, Rossing, Mary Anne, primary, Chenevix-Trench, Georgia, primary, Pharoah, Paul D.P., primary, Gayther, Simon A., primary, Ness, Roberta B., primary, Odunsi, Kunle, primary, Sucheston, Lara E., primary, Knutson, Keith L., primary, and Goode, Ellen L., primary
Published: 2023
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34. Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author: Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary
Published: 2023
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35. Supplementary Tables S1 - S10 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author: Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary
Published: 2023
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36. Supplementary Acknowledgments from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author: Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary
Published: 2023
Full Text: View/download PDF

37. Data from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author: Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary
Published: 2023
Full Text: View/download PDF

38. Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Author: Kar, Siddhartha P., primary, Beesley, Jonathan, primary, Amin Al Olama, Ali, primary, Michailidou, Kyriaki, primary, Tyrer, Jonathan, primary, Kote-Jarai, ZSofia, primary, Lawrenson, Kate, primary, Lindstrom, Sara, primary, Ramus, Susan J., primary, Thompson, Deborah J., primary, Kibel, Adam S., primary, Dansonka-Mieszkowska, Agnieszka, primary, Michael, Agnieszka, primary, Dieffenbach, Aida K., primary, Gentry-Maharaj, Aleksandra, primary, Whittemore, Alice S., primary, Wolk, Alicja, primary, Monteiro, Alvaro, primary, Peixoto, Ana, primary, Kierzek, Andrzej, primary, Cox, Angela, primary, Rudolph, Anja, primary, Gonzalez-Neira, Anna, primary, Wu, Anna H., primary, Lindblom, Annika, primary, Swerdlow, Anthony, primary, Ziogas, Argyrios, primary, Ekici, Arif B., primary, Burwinkel, Barbara, primary, Karlan, Beth Y., primary, Nordestgaard, Børge G., primary, Blomqvist, Carl, primary, Phelan, Catherine, primary, McLean, Catriona, primary, Pearce, Celeste Leigh, primary, Vachon, Celine, primary, Cybulski, Cezary, primary, Slavov, Chavdar, primary, Stegmaier, Christa, primary, Maier, Christiane, primary, Ambrosone, Christine B., primary, Høgdall, Claus K., primary, Teerlink, Craig C., primary, Kang, Daehee, primary, Tessier, Daniel C., primary, Schaid, Daniel J., primary, Stram, Daniel O., primary, Cramer, Daniel W., primary, Neal, David E., primary, Eccles, Diana, primary, Flesch-Janys, Dieter, primary, Edwards, Digna R. Velez, primary, Wokozorczyk, Dominika, primary, Levine, Douglas A., primary, Yannoukakos, Drakoulis, primary, Sawyer, Elinor J., primary, Bandera, Elisa V., primary, Poole, Elizabeth M., primary, Goode, Ellen L., primary, Khusnutdinova, Elza, primary, Høgdall, Estrid, primary, Song, Fengju, primary, Bruinsma, Fiona, primary, Heitz, Florian, primary, Modugno, Francesmary, primary, Hamdy, Freddie C., primary, Wiklund, Fredrik, primary, Giles, Graham G., primary, Olsson, Håkan, primary, Wildiers, Hans, primary, Ulmer, Hans-Ulrich, primary, Pandha, Hardev, primary, Risch, Harvey A., primary, Darabi, Hatef, primary, Salvesen, Helga B., primary, Nevanlinna, Heli, primary, Gronberg, Henrik, primary, Brenner, Hermann, primary, Brauch, Hiltrud, primary, Anton-Culver, Hoda, primary, Song, Honglin, primary, Lim, Hui-Yi, primary, McNeish, Iain, primary, Campbell, Ian, primary, Vergote, Ignace, primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Stanford, Janet L., primary, Benítez, Javier, primary, Doherty, Jennifer A., primary, Permuth, Jennifer B., primary, Chang-Claude, Jenny, primary, Donovan, Jenny L., primary, Dennis, Joe, primary, Schildkraut, Joellen M., primary, Schleutker, Johanna, primary, Hopper, John L., primary, Kupryjanczyk, Jolanta, primary, Park, Jong Y., primary, Figueroa, Jonine, primary, Clements, Judith A., primary, Knight, Julia A., primary, Peto, Julian, primary, Cunningham, Julie M., primary, Pow-Sang, Julio, primary, Batra, Jyotsna, primary, Czene, Kamila, primary, Lu, Karen H., primary, Herkommer, Kathleen, primary, Khaw, Kay-Tee, primary, Matsuo, Keitaro, primary, Muir, Kenneth, primary, Offitt, Kenneth, primary, Chen, Kexin, primary, Moysich, Kirsten B., primary, Aittomäki, Kristiina, primary, Odunsi, Kunle, primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Fitzgerald, Liesel M., primary, Cook, Linda S., primary, Cannon-Albright, Lisa, primary, Hooning, Maartje J., primary, Pike, Malcolm C., primary, Bolla, Manjeet K., primary, Luedeke, Manuel, primary, Teixeira, Manuel R., primary, Goodman, Marc T., primary, Schmidt, Marjanka K., primary, Riggan, Marjorie, primary, Aly, Markus, primary, Rossing, Mary Anne, primary, Beckmann, Matthias W., primary, Moisse, Matthieu, primary, Sanderson, Maureen, primary, Southey, Melissa C., primary, Jones, Michael, primary, Lush, Michael, primary, Hildebrandt, Michelle A.T., primary, Hou, Ming-Feng, primary, Schoemaker, Minouk J., primary, Garcia-Closas, Montserrat, primary, Bogdanova, Natalia, primary, Rahman, Nazneen, primary, Le, Nhu D., primary, Orr, Nick, primary, Wentzensen, Nicolas, primary, Pashayan, Nora, primary, Peterlongo, Paolo, primary, Guénel, Pascal, primary, Brennan, Paul, primary, Paulo, Paula, primary, Webb, Penelope M., primary, Broberg, Per, primary, Fasching, Peter A., primary, Devilee, Peter, primary, Wang, Qin, primary, Cai, Qiuyin, primary, Li, Qiyuan, primary, Kaneva, Radka, primary, Butzow, Ralf, primary, Kopperud, Reidun Kristin, primary, Schmutzler, Rita K., primary, Stephenson, Robert A., primary, MacInnis, Robert J., primary, Hoover, Robert N., primary, Winqvist, Robert, primary, Ness, Roberta, primary, Milne, Roger L., primary, Travis, Ruth C., primary, Benlloch, Sara, primary, Olson, Sara H., primary, McDonnell, Shannon K., primary, Tworoger, Shelley S., primary, Maia, Sofia, primary, Berndt, Sonja, primary, Lee, Soo Chin, primary, Teo, Soo-Hwang, primary, Thibodeau, Stephen N., primary, Bojesen, Stig E., primary, Gapstur, Susan M., primary, Kjær, Susanne Krüger, primary, Pejovic, Tanja, primary, Tammela, Teuvo L.J., primary, Dörk, Thilo, primary, Brüning, Thomas, primary, Wahlfors, Tiina, primary, Key, Tim J., primary, Edwards, Todd L., primary, Menon, Usha, primary, Hamann, Ute, primary, Mitev, Vanio, primary, Kosma, Veli-Matti, primary, Setiawan, Veronica Wendy, primary, Kristensen, Vessela, primary, Arndt, Volker, primary, Vogel, Walther, primary, Zheng, Wei, primary, Sieh, Weiva, primary, Blot, William J., primary, Kluzniak, Wojciech, primary, Shu, Xiao-Ou, primary, Gao, Yu-Tang, primary, Schumacher, Fredrick, primary, Freedman, Matthew L., primary, Berchuck, Andrew, primary, Dunning, Alison M., primary, Simard, Jacques, primary, Haiman, Christopher A., primary, Spurdle, Amanda, primary, Sellers, Thomas A., primary, Hunter, David J., primary, Henderson, Brian E., primary, Kraft, Peter, primary, Chanock, Stephen J., primary, Couch, Fergus J., primary, Hall, Per, primary, Gayther, Simon A., primary, Easton, Douglas F., primary, Chenevix-Trench, Georgia, primary, Eeles, Rosalind, primary, Pharoah, Paul D.P., primary, and Lambrechts, Diether, primary
Published: 2023
Full Text: View/download PDF

39. Supplementary Tables 1 - 4 from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

Author: Charbonneau, Bridget, primary, Moysich, Kirsten B., primary, Kalli, Kimberly R., primary, Oberg, Ann L., primary, Vierkant, Robert A., primary, Fogarty, Zachary C., primary, Block, Matthew S., primary, Maurer, Matthew J., primary, Goergen, Krista M., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, Rider, David N., primary, Preston, Claudia, primary, Hartmann, Lynn C., primary, Lawrenson, Kate, primary, Wang, Chen, primary, Tyrer, Jonathan, primary, Song, Honglin, primary, deFazio, Anna, primary, Johnatty, Sharon E., primary, Doherty, Jennifer A., primary, Phelan, Catherine M., primary, Sellers, Thomas A., primary, Ramirez, Starr M., primary, Vitonis, Allison F., primary, Terry, Kathryn L., primary, Van Den Berg, David, primary, Pike, Malcolm C., primary, Wu, Anna H., primary, Berchuck, Andrew, primary, Gentry-Maharaj, Aleksandra, primary, Ramus, Susan J., primary, Diergaarde, Brenda, primary, Shen, Howard, primary, Jensen, Allan, primary, Menkiszak, Janusz, primary, Cybulski, Cezary, primary, Lubiński, Jan, primary, Ziogas, Argyrios, primary, Rothstein, Joseph H., primary, McGuire, Valerie, primary, Sieh, Weiva, primary, Lester, Jenny, primary, Walsh, Christine, primary, Vergote, Ignace, primary, Lambrechts, Sandrina, primary, Despierre, Evelyn, primary, Garcia-Closas, Montserrat, primary, Yang, Hannah, primary, Brinton, Louise A., primary, Spiewankiewicz, Beata, primary, Rzepecka, Iwona K., primary, Dansonka-Mieszkowska, Agnieszka, primary, Seibold, Petra, primary, Rudolph, Anja, primary, Paddock, Lisa E., primary, Orlow, Irene, primary, Lundvall, Lene, primary, Olson, Sara H., primary, Hogdall, Claus K., primary, Schwaab, Ira, primary, du Bois, Andreas, primary, Harter, Philipp, primary, Flanagan, James M., primary, Brown, Robert, primary, Paul, James, primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Hein, Alexander, primary, Eccles, Diana, primary, Lurie, Galina, primary, Hays, Laura E., primary, Bean, Yukie T., primary, Pejovic, Tanja, primary, Goodman, Marc T., primary, Campbell, Ian, primary, Fasching, Peter A., primary, Konecny, Gottfried, primary, Kaye, Stanley B., primary, Heitz, Florian, primary, Hogdall, Estrid, primary, Bandera, Elisa V., primary, Chang-Claude, Jenny, primary, Kupryjanczyk, Jolanta, primary, Wentzensen, Nicolas, primary, Lambrechts, Diether, primary, Karlan, Beth Y., primary, Whittemore, Alice S., primary, Culver, Hoda Anton, primary, Gronwald, Jacek, primary, Levine, Douglas A., primary, Kjaer, Susanne K., primary, Menon, Usha, primary, Schildkraut, Joellen M., primary, Pearce, Celeste Leigh, primary, Cramer, Daniel W., primary, Rossing, Mary Anne, primary, Chenevix-Trench, Georgia, primary, Pharoah, Paul D.P., primary, Gayther, Simon A., primary, Ness, Roberta B., primary, Odunsi, Kunle, primary, Sucheston, Lara E., primary, Knutson, Keith L., primary, and Goode, Ellen L., primary
Published: 2023
Full Text: View/download PDF

40. Data from Variation in NF-κB Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer

Author: Block, Matthew S., primary, Charbonneau, Bridget, primary, Vierkant, Robert A., primary, Fogarty, Zachary, primary, Bamlet, William R., primary, Pharoah, Paul D.P., primary, Rossing, Mary Anne, primary, Cramer, Daniel, primary, Pearce, Celeste Leigh, primary, Schildkraut, Joellen, primary, Menon, Usha, primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Gronwald, Jacek, primary, Culver, Hoda Anton, primary, Whittemore, Alice S., primary, Karlan, Beth Y., primary, Lambrechts, Diether, primary, Wentzensen, Nicolas, primary, Kupryjanczyk, Jolanta, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Fasching, Peter A., primary, Campbell, Ian, primary, Goodman, Marc T., primary, Pejovic, Tanja, primary, Bean, Yukie T., primary, Hays, Laura E., primary, Lurie, Galina, primary, Eccles, Diana, primary, Hein, Alexander, primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Paul, James, primary, Brown, Robert, primary, Flanagan, James M., primary, Harter, Philipp, primary, du Bois, Andreas, primary, Schwaab, Ira, primary, Hogdall, Claus K., primary, Lundvall, Lene, primary, Olson, Sara H., primary, Orlow, Irene, primary, Paddock, Lisa E., primary, Rudolph, Anja, primary, Eilber, Ursula, primary, Dansonka-Mieszkowska, Agnieszka, primary, Rzepecka, Iwona K., primary, Ziolkowska-Seta, Izabela, primary, Brinton, Louise A., primary, Yang, Hannah, primary, Garcia-Closas, Montserrat, primary, Despierre, Evelyn, primary, Lambrechts, Sandrina, primary, Vergote, Ignace, primary, Walsh, Christine S., primary, Lester, Jenny, primary, Sieh, Weiva, primary, McGuire, Valerie, primary, Rothstein, Joseph H., primary, Ziogas, Argyrios, primary, Lubiński, Jan, primary, Cybulski, Cezary, primary, Menkiszak, Janusz, primary, Jensen, Allan, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Gentry-Maharaj, Aleksandra, primary, Berchuck, Andrew, primary, Wu, Anna H., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Terry, Kathryn L., primary, Vitonis, Allison F., primary, Ramirez, Starr M., primary, Rider, David N., primary, Knutson, Keith L., primary, Sellers, Thomas A., primary, Phelan, Catherine M., primary, Doherty, Jennifer A., primary, Johnatty, Sharon E., primary, deFazio, Anna, primary, Song, Honglin, primary, Tyrer, Jonathan, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, and Goode, Ellen L., primary
Published: 2023
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41. Data from Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

Author: Kar, Siddhartha P., primary, Tyrer, Jonathan P., primary, Li, Qiyuan, primary, Lawrenson, Kate, primary, Aben, Katja K.H., primary, Anton-Culver, Hoda, primary, Antonenkova, Natalia, primary, Chenevix-Trench, Georgia, primary, Baker, Helen, primary, Bandera, Elisa V., primary, Bean, Yukie T., primary, Beckmann, Matthias W., primary, Berchuck, Andrew, primary, Bisogna, Maria, primary, Bjørge, Line, primary, Bogdanova, Natalia, primary, Brinton, Louise, primary, Brooks-Wilson, Angela, primary, Butzow, Ralf, primary, Campbell, Ian, primary, Carty, Karen, primary, Chang-Claude, Jenny, primary, Chen, Yian Ann, primary, Chen, Zhihua, primary, Cook, Linda S., primary, Cramer, Daniel, primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, Dansonka-Mieszkowska, Agnieszka, primary, Dennis, Joe, primary, Dicks, Ed, primary, Doherty, Jennifer A., primary, Dörk, Thilo, primary, du Bois, Andreas, primary, Dürst, Matthias, primary, Eccles, Diana, primary, Easton, Douglas F., primary, Edwards, Robert P., primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Fridley, Brooke L., primary, Gao, Yu-Tang, primary, Gentry-Maharaj, Aleksandra, primary, Giles, Graham G., primary, Glasspool, Rosalind, primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Grownwald, Jacek, primary, Harrington, Patricia, primary, Harter, Philipp, primary, Hein, Alexander, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Hillemanns, Peter, primary, Hogdall, Estrid, primary, Hogdall, Claus K., primary, Hosono, Satoyo, primary, Iversen, Edwin S., primary, Jakubowska, Anna, primary, Paul, James, primary, Jensen, Allan, primary, Ji, Bu-Tian, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Kelemen, Linda E., primary, Kellar, Melissa, primary, Kelley, Joseph, primary, Kiemeney, Lambertus A., primary, Krakstad, Camilla, primary, Kupryjanczyk, Jolanta, primary, Lambrechts, Diether, primary, Lambrechts, Sandrina, primary, Le, Nhu D., primary, Lee, Alice W., primary, Lele, Shashi, primary, Leminen, Arto, primary, Lester, Jenny, primary, Levine, Douglas A., primary, Liang, Dong, primary, Lissowska, Jolanta, primary, Lu, Karen, primary, Lubinski, Jan, primary, Lundvall, Lene, primary, Massuger, Leon, primary, Matsuo, Keitaro, primary, McGuire, Valerie, primary, McLaughlin, John R., primary, McNeish, Iain A., primary, Menon, Usha, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Narod, Steven A., primary, Nedergaard, Lotte, primary, Ness, Roberta B., primary, Nevanlinna, Heli, primary, Odunsi, Kunle, primary, Olson, Sara H., primary, Orlow, Irene, primary, Orsulic, Sandra, primary, Weber, Rachel Palmieri, primary, Pearce, Celeste Leigh, primary, Pejovic, Tanja, primary, Pelttari, Liisa M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pike, Malcolm C., primary, Poole, Elizabeth M., primary, Ramus, Susan J., primary, Risch, Harvey A., primary, Rosen, Barry, primary, Rossing, Mary Anne, primary, Rothstein, Joseph H., primary, Rudolph, Anja, primary, Runnebaum, Ingo B., primary, Rzepecka, Iwona K., primary, Salvesen, Helga B., primary, Schildkraut, Joellen M., primary, Schwaab, Ira, primary, Shu, Xiao-Ou, primary, Shvetsov, Yurii B., primary, Siddiqui, Nadeem, primary, Sieh, Weiva, primary, Song, Honglin, primary, Southey, Melissa C., primary, Sucheston-Campbell, Lara E., primary, Tangen, Ingvild L., primary, Teo, Soo-Hwang, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Timorek, Agnieszka, primary, Tsai, Ya-Yu, primary, Tworoger, Shelley S., primary, van Altena, Anne M., primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Vierkant, Robert A., primary, Wang-Gohrke, Shan, primary, Walsh, Christine, primary, Wentzensen, Nicolas, primary, Whittemore, Alice S., primary, Wicklund, Kristine G., primary, Wilkens, Lynne R., primary, Woo, Yin-Ling, primary, Wu, Xifeng, primary, Wu, Anna, primary, Yang, Hannah, primary, Zheng, Wei, primary, Ziogas, Argyrios, primary, Sellers, Thomas A., primary, Monteiro, Alvaro N.A., primary, Freedman, Matthew L., primary, Gayther, Simon A., primary, and Pharoah, Paul D.P., primary
Published: 2023
Full Text: View/download PDF

42. Supplementary Tables S1-6, Figures S1-2 from Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

Author: Kar, Siddhartha P., primary, Tyrer, Jonathan P., primary, Li, Qiyuan, primary, Lawrenson, Kate, primary, Aben, Katja K.H., primary, Anton-Culver, Hoda, primary, Antonenkova, Natalia, primary, Chenevix-Trench, Georgia, primary, Baker, Helen, primary, Bandera, Elisa V., primary, Bean, Yukie T., primary, Beckmann, Matthias W., primary, Berchuck, Andrew, primary, Bisogna, Maria, primary, Bjørge, Line, primary, Bogdanova, Natalia, primary, Brinton, Louise, primary, Brooks-Wilson, Angela, primary, Butzow, Ralf, primary, Campbell, Ian, primary, Carty, Karen, primary, Chang-Claude, Jenny, primary, Chen, Yian Ann, primary, Chen, Zhihua, primary, Cook, Linda S., primary, Cramer, Daniel, primary, Cunningham, Julie M., primary, Cybulski, Cezary, primary, Dansonka-Mieszkowska, Agnieszka, primary, Dennis, Joe, primary, Dicks, Ed, primary, Doherty, Jennifer A., primary, Dörk, Thilo, primary, du Bois, Andreas, primary, Dürst, Matthias, primary, Eccles, Diana, primary, Easton, Douglas F., primary, Edwards, Robert P., primary, Ekici, Arif B., primary, Fasching, Peter A., primary, Fridley, Brooke L., primary, Gao, Yu-Tang, primary, Gentry-Maharaj, Aleksandra, primary, Giles, Graham G., primary, Glasspool, Rosalind, primary, Goode, Ellen L., primary, Goodman, Marc T., primary, Grownwald, Jacek, primary, Harrington, Patricia, primary, Harter, Philipp, primary, Hein, Alexander, primary, Heitz, Florian, primary, Hildebrandt, Michelle A.T., primary, Hillemanns, Peter, primary, Hogdall, Estrid, primary, Hogdall, Claus K., primary, Hosono, Satoyo, primary, Iversen, Edwin S., primary, Jakubowska, Anna, primary, Paul, James, primary, Jensen, Allan, primary, Ji, Bu-Tian, primary, Karlan, Beth Y., primary, Kjaer, Susanne K., primary, Kelemen, Linda E., primary, Kellar, Melissa, primary, Kelley, Joseph, primary, Kiemeney, Lambertus A., primary, Krakstad, Camilla, primary, Kupryjanczyk, Jolanta, primary, Lambrechts, Diether, primary, Lambrechts, Sandrina, primary, Le, Nhu D., primary, Lee, Alice W., primary, Lele, Shashi, primary, Leminen, Arto, primary, Lester, Jenny, primary, Levine, Douglas A., primary, Liang, Dong, primary, Lissowska, Jolanta, primary, Lu, Karen, primary, Lubinski, Jan, primary, Lundvall, Lene, primary, Massuger, Leon, primary, Matsuo, Keitaro, primary, McGuire, Valerie, primary, McLaughlin, John R., primary, McNeish, Iain A., primary, Menon, Usha, primary, Modugno, Francesmary, primary, Moysich, Kirsten B., primary, Narod, Steven A., primary, Nedergaard, Lotte, primary, Ness, Roberta B., primary, Nevanlinna, Heli, primary, Odunsi, Kunle, primary, Olson, Sara H., primary, Orlow, Irene, primary, Orsulic, Sandra, primary, Weber, Rachel Palmieri, primary, Pearce, Celeste Leigh, primary, Pejovic, Tanja, primary, Pelttari, Liisa M., primary, Permuth-Wey, Jennifer, primary, Phelan, Catherine M., primary, Pike, Malcolm C., primary, Poole, Elizabeth M., primary, Ramus, Susan J., primary, Risch, Harvey A., primary, Rosen, Barry, primary, Rossing, Mary Anne, primary, Rothstein, Joseph H., primary, Rudolph, Anja, primary, Runnebaum, Ingo B., primary, Rzepecka, Iwona K., primary, Salvesen, Helga B., primary, Schildkraut, Joellen M., primary, Schwaab, Ira, primary, Shu, Xiao-Ou, primary, Shvetsov, Yurii B., primary, Siddiqui, Nadeem, primary, Sieh, Weiva, primary, Song, Honglin, primary, Southey, Melissa C., primary, Sucheston-Campbell, Lara E., primary, Tangen, Ingvild L., primary, Teo, Soo-Hwang, primary, Terry, Kathryn L., primary, Thompson, Pamela J., primary, Timorek, Agnieszka, primary, Tsai, Ya-Yu, primary, Tworoger, Shelley S., primary, van Altena, Anne M., primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Vierkant, Robert A., primary, Wang-Gohrke, Shan, primary, Walsh, Christine, primary, Wentzensen, Nicolas, primary, Whittemore, Alice S., primary, Wicklund, Kristine G., primary, Wilkens, Lynne R., primary, Woo, Yin-Ling, primary, Wu, Xifeng, primary, Wu, Anna, primary, Yang, Hannah, primary, Zheng, Wei, primary, Ziogas, Argyrios, primary, Sellers, Thomas A., primary, Monteiro, Alvaro N.A., primary, Freedman, Matthew L., primary, Gayther, Simon A., primary, and Pharoah, Paul D.P., primary
Published: 2023
Full Text: View/download PDF

43. Supplementary Figures 1-5, Tables 1-8 from Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

Author: Johnatty, Sharon E., primary, Tyrer, Jonathan P., primary, Kar, Siddhartha, primary, Beesley, Jonathan, primary, Lu, Yi, primary, Gao, Bo, primary, Fasching, Peter A., primary, Hein, Alexander, primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Lambrechts, Diether, primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Lambrechts, Sandrina, primary, Rossing, Mary Anne, primary, Doherty, Jennifer A., primary, Chang-Claude, Jenny, primary, Modugno, Francesmary, primary, Ness, Roberta B., primary, Moysich, Kirsten B., primary, Levine, Douglas A., primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Jakubowska, Anna, primary, Cybulski, Cezary, primary, Brinton, Louise, primary, Lissowska, Jolanta, primary, Wentzensen, Nicolas, primary, Song, Honglin, primary, Rhenius, Valerie, primary, Campbell, Ian, primary, Eccles, Diana, primary, Sieh, Weiva, primary, Whittemore, Alice S., primary, McGuire, Valerie, primary, Rothstein, Joseph H., primary, Sutphen, Rebecca, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Ramus, Susan J., primary, Pearce, Celeste L., primary, Pike, Malcolm C., primary, Stram, Daniel O., primary, Wu, Anna H., primary, Kupryjanczyk, Jolanta, primary, Dansonka-Mieszkowska, Agnieszka, primary, Rzepecka, Iwona K., primary, Spiewankiewicz, Beata, primary, Goodman, Marc T., primary, Wilkens, Lynne R., primary, Carney, Michael E., primary, Thompson, Pamela J., primary, Heitz, Florian, primary, du Bois, Andreas, primary, Schwaab, Ira, primary, Harter, Philipp, primary, Pisterer, Jacobus, primary, Hillemanns, Peter, primary, Karlan, Beth Y., primary, Walsh, Christine, primary, Lester, Jenny, primary, Orsulic, Sandra, primary, Winham, Stacey J., primary, Earp, Madalene, primary, Larson, Melissa C., primary, Fogarty, Zachary C., primary, Høgdall, Estrid, primary, Jensen, Allan, primary, Kjaer, Susanne Kruger, primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, Vierkant, Robert A., primary, Schildkraut, Joellen M., primary, Iversen, Edwin S., primary, Terry, Kathryn L., primary, Cramer, Daniel W., primary, Bandera, Elisa V., primary, Orlow, Irene, primary, Pejovic, Tanja, primary, Bean, Yukie, primary, Høgdall, Claus, primary, Lundvall, Lene, primary, McNeish, Ian, primary, Paul, James, primary, Carty, Karen, primary, Siddiqui, Nadeem, primary, Glasspool, Rosalind, primary, Sellers, Thomas, primary, Kennedy, Catherine, primary, Chiew, Yoke-Eng, primary, Berchuck, Andrew, primary, MacGregor, Stuart, primary, Pharoah, Paul D.P., primary, Goode, Ellen L., primary, deFazio, Anna, primary, Webb, Penelope M., primary, and Chenevix-Trench, Georgia, primary
Published: 2023
Full Text: View/download PDF

44. Supplementary Tables 1 through 3 from Variation in NF-κB Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer

Author: Block, Matthew S., primary, Charbonneau, Bridget, primary, Vierkant, Robert A., primary, Fogarty, Zachary, primary, Bamlet, William R., primary, Pharoah, Paul D.P., primary, Rossing, Mary Anne, primary, Cramer, Daniel, primary, Pearce, Celeste Leigh, primary, Schildkraut, Joellen, primary, Menon, Usha, primary, Kjaer, Susanne K., primary, Levine, Douglas A., primary, Gronwald, Jacek, primary, Culver, Hoda Anton, primary, Whittemore, Alice S., primary, Karlan, Beth Y., primary, Lambrechts, Diether, primary, Wentzensen, Nicolas, primary, Kupryjanczyk, Jolanta, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Fasching, Peter A., primary, Campbell, Ian, primary, Goodman, Marc T., primary, Pejovic, Tanja, primary, Bean, Yukie T., primary, Hays, Laura E., primary, Lurie, Galina, primary, Eccles, Diana, primary, Hein, Alexander, primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Paul, James, primary, Brown, Robert, primary, Flanagan, James M., primary, Harter, Philipp, primary, du Bois, Andreas, primary, Schwaab, Ira, primary, Hogdall, Claus K., primary, Lundvall, Lene, primary, Olson, Sara H., primary, Orlow, Irene, primary, Paddock, Lisa E., primary, Rudolph, Anja, primary, Eilber, Ursula, primary, Dansonka-Mieszkowska, Agnieszka, primary, Rzepecka, Iwona K., primary, Ziolkowska-Seta, Izabela, primary, Brinton, Louise A., primary, Yang, Hannah, primary, Garcia-Closas, Montserrat, primary, Despierre, Evelyn, primary, Lambrechts, Sandrina, primary, Vergote, Ignace, primary, Walsh, Christine S., primary, Lester, Jenny, primary, Sieh, Weiva, primary, McGuire, Valerie, primary, Rothstein, Joseph H., primary, Ziogas, Argyrios, primary, Lubiński, Jan, primary, Cybulski, Cezary, primary, Menkiszak, Janusz, primary, Jensen, Allan, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Gentry-Maharaj, Aleksandra, primary, Berchuck, Andrew, primary, Wu, Anna H., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Terry, Kathryn L., primary, Vitonis, Allison F., primary, Ramirez, Starr M., primary, Rider, David N., primary, Knutson, Keith L., primary, Sellers, Thomas A., primary, Phelan, Catherine M., primary, Doherty, Jennifer A., primary, Johnatty, Sharon E., primary, deFazio, Anna, primary, Song, Honglin, primary, Tyrer, Jonathan, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, and Goode, Ellen L., primary
Published: 2023
Full Text: View/download PDF

45. Data from Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

Author: Johnatty, Sharon E., primary, Tyrer, Jonathan P., primary, Kar, Siddhartha, primary, Beesley, Jonathan, primary, Lu, Yi, primary, Gao, Bo, primary, Fasching, Peter A., primary, Hein, Alexander, primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Lambrechts, Diether, primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Lambrechts, Sandrina, primary, Rossing, Mary Anne, primary, Doherty, Jennifer A., primary, Chang-Claude, Jenny, primary, Modugno, Francesmary, primary, Ness, Roberta B., primary, Moysich, Kirsten B., primary, Levine, Douglas A., primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Jakubowska, Anna, primary, Cybulski, Cezary, primary, Brinton, Louise, primary, Lissowska, Jolanta, primary, Wentzensen, Nicolas, primary, Song, Honglin, primary, Rhenius, Valerie, primary, Campbell, Ian, primary, Eccles, Diana, primary, Sieh, Weiva, primary, Whittemore, Alice S., primary, McGuire, Valerie, primary, Rothstein, Joseph H., primary, Sutphen, Rebecca, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Ramus, Susan J., primary, Pearce, Celeste L., primary, Pike, Malcolm C., primary, Stram, Daniel O., primary, Wu, Anna H., primary, Kupryjanczyk, Jolanta, primary, Dansonka-Mieszkowska, Agnieszka, primary, Rzepecka, Iwona K., primary, Spiewankiewicz, Beata, primary, Goodman, Marc T., primary, Wilkens, Lynne R., primary, Carney, Michael E., primary, Thompson, Pamela J., primary, Heitz, Florian, primary, du Bois, Andreas, primary, Schwaab, Ira, primary, Harter, Philipp, primary, Pisterer, Jacobus, primary, Hillemanns, Peter, primary, Karlan, Beth Y., primary, Walsh, Christine, primary, Lester, Jenny, primary, Orsulic, Sandra, primary, Winham, Stacey J., primary, Earp, Madalene, primary, Larson, Melissa C., primary, Fogarty, Zachary C., primary, Høgdall, Estrid, primary, Jensen, Allan, primary, Kjaer, Susanne Kruger, primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, Vierkant, Robert A., primary, Schildkraut, Joellen M., primary, Iversen, Edwin S., primary, Terry, Kathryn L., primary, Cramer, Daniel W., primary, Bandera, Elisa V., primary, Orlow, Irene, primary, Pejovic, Tanja, primary, Bean, Yukie, primary, Høgdall, Claus, primary, Lundvall, Lene, primary, McNeish, Ian, primary, Paul, James, primary, Carty, Karen, primary, Siddiqui, Nadeem, primary, Glasspool, Rosalind, primary, Sellers, Thomas, primary, Kennedy, Catherine, primary, Chiew, Yoke-Eng, primary, Berchuck, Andrew, primary, MacGregor, Stuart, primary, Pharoah, Paul D.P., primary, Goode, Ellen L., primary, deFazio, Anna, primary, Webb, Penelope M., primary, and Chenevix-Trench, Georgia, primary
Published: 2023
Full Text: View/download PDF

46. Data from Risk of Ovarian Cancer and the NF-κB Pathway: Genetic Association with IL1A and TNFSF10

Author: Charbonneau, Bridget, primary, Block, Matthew S., primary, Bamlet, William R., primary, Vierkant, Robert A., primary, Kalli, Kimberly R., primary, Fogarty, Zachary, primary, Rider, David N., primary, Sellers, Thomas A., primary, Tworoger, Shelley S., primary, Poole, Elizabeth, primary, Risch, Harvey A., primary, Salvesen, Helga B., primary, Kiemeney, Lambertus A., primary, Baglietto, Laura, primary, Giles, Graham G., primary, Severi, Gianluca, primary, Trabert, Britton, primary, Wentzensen, Nicolas, primary, Chenevix-Trench, Georgia, primary, Whittemore, Alice S., primary, Sieh, Weiva, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Orlow, Irene, primary, Terry, Kathryn, primary, Goodman, Marc T., primary, Thompson, Pamela J., primary, Cook, Linda S., primary, Rossing, Mary Anne, primary, Ness, Roberta B., primary, Narod, Steven A., primary, Kupryjanczyk, Jolanta, primary, Lu, Karen, primary, Butzow, Ralf, primary, Dörk, Thilo, primary, Pejovic, Tanja, primary, Campbell, Ian, primary, Le, Nhu D., primary, Bunker, Clareann H., primary, Bogdanova, Natalia, primary, Runnebaum, Ingo B., primary, Eccles, Diana, primary, Paul, James, primary, Wu, Anna H., primary, Gayther, Simon A., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Karlan, Beth Y., primary, Anton-Culver, Hoda, primary, Gronwald, Jacek, primary, Hogdall, Claus K., primary, Lambrechts, Diether, primary, Fasching, Peter A., primary, Menon, Usha, primary, Schildkraut, Joellen, primary, Pearce, Celeste Leigh, primary, Levine, Douglas A., primary, Kjaer, Susanne Kruger, primary, Cramer, Daniel, primary, Flanagan, James M., primary, Phelan, Catherine M., primary, Brown, Robert, primary, Massuger, Leon F.A.G., primary, Song, Honglin, primary, Doherty, Jennifer A., primary, Krakstad, Camilla, primary, Liang, Dong, primary, Odunsi, Kunle, primary, Berchuck, Andrew, primary, Jensen, Allan, primary, Lubiński, Jan, primary, Nevanlinna, Heli, primary, Bean, Yukie T., primary, Lurie, Galina, primary, Ziogas, Argyrios, primary, Walsh, Christine, primary, Despierre, Evelyn, primary, Brinton, Louise, primary, Hein, Alexander, primary, Rudolph, Anja, primary, Dansonka-Mieszkowska, Agnieszka, primary, Olson, Sara H., primary, Harter, Philipp, primary, Tyrer, Jonathan, primary, Vitonis, Allison F., primary, Brooks-Wilson, Angela, primary, Aben, Katja K., primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Wik, Elisabeth, primary, Cybulski, Cezary, primary, Lin, Jie, primary, Sucheston, Lara, primary, Edwards, Robert, primary, McGuire, Valerie, primary, Lester, Jenny, primary, du Bois, Andreas, primary, Lundvall, Lene, primary, Wang-Gohrke, Shan, primary, Szafron, Lukasz M., primary, Lambrechts, Sandrina, primary, Yang, Hannah, primary, Beckmann, Matthias W., primary, Pelttari, Liisa M., primary, Van Altena, Anne M., primary, van den Berg, David, primary, Halle, Mari K., primary, Gentry-Maharaj, Aleksandra, primary, Schwaab, Ira, primary, Chandran, Urmila, primary, Menkiszak, Janusz, primary, Ekici, Arif B., primary, Wilkens, Lynne R., primary, Leminen, Arto, primary, Modugno, Francesmary, primary, Friel, Grace, primary, Rothstein, Joseph H., primary, Vergote, Ignace, primary, Garcia-Closas, Montserrat, primary, Hildebrandt, Michelle A.T., primary, Sobiczewski, Piotr, primary, Kelemen, Linda E., primary, Pharoah, Paul D.P., primary, Moysich, Kirsten, primary, Knutson, Keith L., primary, Cunningham, Julie M., primary, Fridley, Brooke L., primary, and Goode, Ellen L., primary
Published: 2023
Full Text: View/download PDF

47. Supplementary Tables 1 - 5 from Risk of Ovarian Cancer and the NF-κB Pathway: Genetic Association with IL1A and TNFSF10

Author: Charbonneau, Bridget, primary, Block, Matthew S., primary, Bamlet, William R., primary, Vierkant, Robert A., primary, Kalli, Kimberly R., primary, Fogarty, Zachary, primary, Rider, David N., primary, Sellers, Thomas A., primary, Tworoger, Shelley S., primary, Poole, Elizabeth, primary, Risch, Harvey A., primary, Salvesen, Helga B., primary, Kiemeney, Lambertus A., primary, Baglietto, Laura, primary, Giles, Graham G., primary, Severi, Gianluca, primary, Trabert, Britton, primary, Wentzensen, Nicolas, primary, Chenevix-Trench, Georgia, primary, Whittemore, Alice S., primary, Sieh, Weiva, primary, Chang-Claude, Jenny, primary, Bandera, Elisa V., primary, Orlow, Irene, primary, Terry, Kathryn, primary, Goodman, Marc T., primary, Thompson, Pamela J., primary, Cook, Linda S., primary, Rossing, Mary Anne, primary, Ness, Roberta B., primary, Narod, Steven A., primary, Kupryjanczyk, Jolanta, primary, Lu, Karen, primary, Butzow, Ralf, primary, Dörk, Thilo, primary, Pejovic, Tanja, primary, Campbell, Ian, primary, Le, Nhu D., primary, Bunker, Clareann H., primary, Bogdanova, Natalia, primary, Runnebaum, Ingo B., primary, Eccles, Diana, primary, Paul, James, primary, Wu, Anna H., primary, Gayther, Simon A., primary, Hogdall, Estrid, primary, Heitz, Florian, primary, Kaye, Stanley B., primary, Karlan, Beth Y., primary, Anton-Culver, Hoda, primary, Gronwald, Jacek, primary, Hogdall, Claus K., primary, Lambrechts, Diether, primary, Fasching, Peter A., primary, Menon, Usha, primary, Schildkraut, Joellen, primary, Pearce, Celeste Leigh, primary, Levine, Douglas A., primary, Kjaer, Susanne Kruger, primary, Cramer, Daniel, primary, Flanagan, James M., primary, Phelan, Catherine M., primary, Brown, Robert, primary, Massuger, Leon F.A.G., primary, Song, Honglin, primary, Doherty, Jennifer A., primary, Krakstad, Camilla, primary, Liang, Dong, primary, Odunsi, Kunle, primary, Berchuck, Andrew, primary, Jensen, Allan, primary, Lubiński, Jan, primary, Nevanlinna, Heli, primary, Bean, Yukie T., primary, Lurie, Galina, primary, Ziogas, Argyrios, primary, Walsh, Christine, primary, Despierre, Evelyn, primary, Brinton, Louise, primary, Hein, Alexander, primary, Rudolph, Anja, primary, Dansonka-Mieszkowska, Agnieszka, primary, Olson, Sara H., primary, Harter, Philipp, primary, Tyrer, Jonathan, primary, Vitonis, Allison F., primary, Brooks-Wilson, Angela, primary, Aben, Katja K., primary, Pike, Malcolm C., primary, Ramus, Susan J., primary, Wik, Elisabeth, primary, Cybulski, Cezary, primary, Lin, Jie, primary, Sucheston, Lara, primary, Edwards, Robert, primary, McGuire, Valerie, primary, Lester, Jenny, primary, du Bois, Andreas, primary, Lundvall, Lene, primary, Wang-Gohrke, Shan, primary, Szafron, Lukasz M., primary, Lambrechts, Sandrina, primary, Yang, Hannah, primary, Beckmann, Matthias W., primary, Pelttari, Liisa M., primary, Van Altena, Anne M., primary, van den Berg, David, primary, Halle, Mari K., primary, Gentry-Maharaj, Aleksandra, primary, Schwaab, Ira, primary, Chandran, Urmila, primary, Menkiszak, Janusz, primary, Ekici, Arif B., primary, Wilkens, Lynne R., primary, Leminen, Arto, primary, Modugno, Francesmary, primary, Friel, Grace, primary, Rothstein, Joseph H., primary, Vergote, Ignace, primary, Garcia-Closas, Montserrat, primary, Hildebrandt, Michelle A.T., primary, Sobiczewski, Piotr, primary, Kelemen, Linda E., primary, Pharoah, Paul D.P., primary, Moysich, Kirsten, primary, Knutson, Keith L., primary, Cunningham, Julie M., primary, Fridley, Brooke L., primary, and Goode, Ellen L., primary
Published: 2023
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48. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Author: Hollestelle, Antoinette, van der Baan, Frederieke H., Berchuck, Andrew, Johnatty, Sharon E., Aben, Katja K., Agnarsson, Bjarni A., Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Antoniou, Antonis C., Apicella, Carmel, Arndt, Volker, Arnold, Norbert, Arun, Banu K., Arver, Brita, Ashworth, Alan, Baglietto, Laura, Balleine, Rosemary, Bandera, Elisa V., Barrowdale, Daniel, Bean, Yukie T., Beckmann, Lars, Beckmann, Matthias W., Benitez, Javier, Berger, Andreas, Berger, Raanan, Beuselinck, Benoit, Bisogna, Maria, Bjorge, Line, Blomqvist, Carl, Bogdanova, Natalia V., Bojesen, Anders, Bojesen, Stig E., Bolla, Manjeet K., Bonanni, Bernardo, Brand, Judith S., Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Brüning, Thomas, Budzilowska, Agnieszka, Bunker, Clareann H., Burwinkel, Barbara, Butzow, Ralf, Buys, Saundra S., Caligo, Maria A., Campbell, Ian, Carter, Jonathan, Chang-Claude, Jenny, Chanock, Stephen J., Claes, Kathleen B.M., Collée, J. Margriet, Cook, Linda S., Couch, Fergus J., Cox, Angela, Cramer, Daniel, Cross, Simon S., Cunningham, Julie M., Cybulski, Cezary, Czene, Kamila, Damiola, Francesca, Dansonka-Mieszkowska, Agnieszka, Darabi, Hatef, de la Hoya, Miguel, deFazio, Anna, Dennis, Joseph, Devilee, Peter, Dicks, Ed M., Diez, Orland, Doherty, Jennifer A., Domchek, Susan M., Dorfling, Cecilia M., Dörk, Thilo, Silva, Isabel Dos Santos, du Bois, Andreas, Dumont, Martine, Dunning, Alison M., Duran, Mercedes, Easton, Douglas F., Eccles, Diana, Edwards, Robert P., Ehrencrona, Hans, Ejlertsen, Bent, Ekici, Arif B., Ellis, Steve D., Engel, Christoph, Eriksson, Mikael, Fasching, Peter A., Feliubadalo, Lidia, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Fontaine, Annette, Fortuzzi, Stefano, Fostira, Florentia, Fridley, Brooke L., Friebel, Tara, Friedman, Eitan, Friel, Grace, Frost, Debra, Garber, Judy, García-Closas, Montserrat, Gayther, Simon A., Gentry-Maharaj, Aleksandra, Gerdes, Anne-Marie, Giles, Graham G., Glasspool, Rosalind, Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Gore, Martin, Greene, Mark H., Grip, Mervi, Gronwald, Jacek, Gschwantler Kaulich, Daphne, Guénel, Pascal, Guzman, Starr R., Haeberle, Lothar, Haiman, Christopher A., Hall, Per, Halverson, Sandra L., Hamann, Ute, Hansen, Thomas V.O., Harter, Philipp, Hartikainen, Jaana M., Healey, Sue, Hein, Alexander, Heitz, Florian, Henderson, Brian E., Herzog, Josef, T Hildebrandt, Michelle A., Høgdall, Claus K., Høgdall, Estrid, Hogervorst, Frans B.L., Hopper, John L., Humphreys, Keith, Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna, Janavicius, Ramunas, Jaworska, Katarzyna, Jensen, Allan, Jensen, Uffe Birk, Johnson, Nichola, Jukkola-Vuorinen, Arja, Kabisch, Maria, Karlan, Beth Y., Kataja, Vesa, Kauff, Noah, Kelemen, Linda E., Kerin, Michael J., Kiemeney, Lambertus A., Kjaer, Susanne K., Knight, Julia A., Knol-Bout, Jacoba P., Konstantopoulou, Irene, Kosma, Veli-Matti, Krakstad, Camilla, Kristensen, Vessela, Kuchenbaecker, Karoline B., Kupryjanczyk, Jolanta, Laitman, Yael, Lambrechts, Diether, Lambrechts, Sandrina, Larson, Melissa C., Lasa, Adriana, Laurent-Puig, Pierre, Lazaro, Conxi, Le, Nhu D., Le Marchand, Loic, Leminen, Arto, Lester, Jenny, Levine, Douglas A., Li, Jingmei, Liang, Dong, Lindblom, Annika, Lindor, Noralane, Lissowska, Jolanta, Long, Jirong, Lu, Karen H., Lubinski, Jan, Lundvall, Lene, Lurie, Galina, Mai, Phuong L., Mannermaa, Arto, Margolin, Sara, Mariette, Frederique, Marme, Frederik, Martens, John W.M., Massuger, Leon F.A.G., Maugard, Christine, Mazoyer, Sylvie, McGuffog, Lesley, McGuire, Valerie, McLean, Catriona, McNeish, Iain, Meindl, Alfons, Menegaux, Florence, Menéndez, Primitiva, Menkiszak, Janusz, Menon, Usha, Mensenkamp, Arjen R., Miller, Nicola, Milne, Roger L., Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Müller, Heiko, Mulligan, Anna Marie, Muranen, Taru A., Narod, Steven A., Nathanson, Katherine L., Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Neven, Patrick, Nielsen, Finn C., Nielsen, Sune F., Nordestgaard, Børge G., Nussbaum, Robert L., Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Olson, Janet E., Olson, Sara H., Oosterwijk, Jan C., Orlow, Irene, Orr, Nick, Orsulic, Sandra, Osorio, Ana, Ottini, Laura, Paul, James, Pearce, Celeste L., Pedersen, Inge Sokilde, Peissel, Bernard, Pejovic, Tanja, Pelttari, Liisa M., Perkins, Jo, Permuth-Wey, Jenny, Peterlongo, Paolo, Peto, Julian, Phelan, Catherine M., Phillips, Kelly-Anne, Piedmonte, Marion, Pike, Malcolm C., Platte, Radka, Plisiecka-Halasa, Joanna, Poole, Elizabeth M., Poppe, Bruce, Pylkäs, Katri, Radice, Paolo, Ramus, Susan J., Rebbeck, Timothy R., Reed, Malcolm W.R., Rennert, Gad, Risch, Harvey A., Robson, Mark, Rodriguez, Gustavo C., Romero, Atocha, Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo, Salani, Ritu, Salvesen, Helga B., Sawyer, Elinor J., Schildkraut, Joellen M., Schmidt, Marjanka K., Schmutzler, Rita K., Schneeweiss, Andreas, Schoemaker, Minouk J., Schrauder, Michael G., Schumacher, Fredrick, Schwaab, Ira, Scuvera, Giulietta, Sellers, Thomas A., Severi, Gianluca, Seynaeve, Caroline M., Shah, Mitul, Shrubsole, Martha, Siddiqui, Nadeem, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sinilnikova, Olga M., Smeets, Dominiek, Sohn, Christof, Soller, Maria, Song, Honglin, Soucy, Penny, Southey, Melissa C., Stegmaier, Christa, Stoppa-Lyonnet, Dominique, Sucheston, Lara, Swerdlow, Anthony, Tangen, Ingvild L., Tea, Muy-Kheng, Teixeira, Manuel R., Terry, Kathryn L., Terry, Mary Beth, Thomassen, Mads, Thompson, Pamela J., Tihomirova, Laima, Tischkowitz, Marc, Toland, Amanda Ewart, Tollenaar, Rob A.E.M., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Tsimiklis, Helen, Tung, Nadine, Tworoger, Shelley S., Tyrer, Jonathan P., Vachon, Celine M., Van 't Veer, Laura J., van Altena, Anne M., Van Asperen, C.J., van den Berg, David, van den Ouweland, Ans M.W., van Doorn, Helena C., Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J., Vergote, Ignace, Verhoef, Senno, Vierkant, Robert A., Vijai, Joseph, Vitonis, Allison F., von Wachenfeldt, Anna, Walsh, Christine, Wang, Qin, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weischer, Maren, Weitzel, Jeffrey N., Weltens, Caroline, Wentzensen, Nicolas, Whittemore, Alice S., Wilkens, Lynne R., Winqvist, Robert, Wu, Anna H., Wu, Xifeng, Yang, Hannah P., Zaffaroni, Daniela, Pilar Zamora, M., Zheng, Wei, Ziogas, Argyrios, Chenevix-Trench, Georgia, Pharoah, Paul D.P., Rookus, Matti A., Hooning, Maartje J., and Goode, Ellen L.
Published: 2016
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49. Unsupervised analysis reveals two molecular subgroups of serous ovarian cancer with distinct gene expression profiles and survival

Author: Lisowska, Katarzyna M., Olbryt, Magdalena, Student, Sebastian, Kujawa, Katarzyna A., Cortez, Alexander J., Simek, Krzysztof, Dansonka-Mieszkowska, Agnieszka, Rzepecka, Iwona K., Tudrej, Patrycja, and Kupryjańczyk, Jolanta
Published: 2016
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50. PROM1, CXCL8, RUNX1, NAV1 and TP73 genes as independent markers predictive of prognosis or response to treatment in two cohorts of high-grade serous ovarian cancer patients

Author: Dansonka-Mieszkowska, Agnieszka, primary, Szafron, Laura Aleksandra, additional, Kulesza, Magdalena, additional, Stachurska, Anna, additional, Leszczynski, Pawel, additional, Tomczyk-Szatkowska, Agnieszka, additional, Sobiczewski, Piotr, additional, Parada, Joanna, additional, Kulinczak, Mariusz, additional, Moes-Sosnowska, Joanna, additional, Pienkowska-Grela, Barbara, additional, Kupryjanczyk, Jolanta, additional, Chechlinska, Magdalena, additional, and Szafron, Lukasz Michal, additional
Published: 2022
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