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This paper aims to discuss cross-cultural empathy and ways to promote the development of empathy in various cultures. Empathy is considered one of the most indispensable traits in every society. However, the concept of empathy differs in different communities, due to social, cultural, and religious influences. According to Mencius, empathy contributes to the expansion of moral cultivation. A core concept in Confucianism, benevolence (Ren), represents the relationship between people. The practice of compassion requires the ability to conduct moral reasoning. The development of such an ability relies heavily on empathy. Since empathy is crucial to people’s daily life in developing critical skills and relationships, fostering empathy in different cultures is helpful. Even though empathy varies significantly in many ways among different cultures, it possesses some fundamental similarities in all of them. The Golden Rule is an excellent example of an ethical principle that could be found in almost all civilizations. Respecting the differences in various cultures, learning more about other cultures and their social norms, and avoiding talking about sensitive topics can help people become more empathetic.

Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure. Lymphangiogenesis is a crucial step in lymphatic metastasis of NPC, while little is known about lymphangiogenesis in NPC. Similar to angiogenesis, lymphangitic neovascularization is a process of balance between pro-lymphangiogenesis and anti-lymphangiogenesis factors, but there are few studies on endogenous lymphangiogenesis inhibitors. Pigment epithelium-derived factor (PEDF) is a well-known effective endogenous angiogenesis inhibitor. However, the relationship between PEDF and lymphangiogenesis remains unknown. Our present study reveals that PEDF is lowly expressed in human NPC tissues with poor prognosis and is negatively correlated with lymphatic vessel density (LVD). Consistently, PEDF inhibits lymphangiogenesis and lymphatic metastasis of NPC in vivo experiments. Mechanistically, PEDF inhibits the proliferation, migration, and tube formation of lymphatic endothelial cells and promotes cell apoptosis. On the other hand, PEDF reduces the expression and secretion of vascular endothelial growth factor C (VEGF-C) of NPC cells through the nuclear factor-κB (NF-κB) signaling pathway. Our findings indicate that PEDF plays a vital role in lymphatic metastasis by targeting both lymphatic endothelial cells and NPC cells, and PEDF may represent a novel therapeutic target for NPC.

Tumour‐associated macrophages (TAMs), which possess M2‐like characters and are derived from immature monocytes in the circulatory system, represent a predominant population of inflammatory cells in solid tumours. TAM infiltration in tumour microenvironment can be used as an important prognostic marker in many cancer types and is a potential target for cancer prevention or treatment. VEGI‐251 not only is involved in the inhibition of tumour angiogenesis, but also participates in the regulation of host immunity. This work aimed to investigate the involvement of VEGI‐251 in the regulation of specific antitumour immunity. We found that recombinant human VEGI‐251(rhVEGI‐251) efficiently mediated the elimination of TAMs in tumour tissue in mice, and induced apoptosis of purified TAMs in vitro. During this process, caspase‐8 and caspase‐3 were activated, leading to PARP cleavage and apoptosis. Most importantly, we further elucidated the mechanism underlying VEGI‐251‐triggered TAM apoptosis, which suggests that ASK1, an intermediate component of the VEGI‐251, activates the JNK pathway via TRAF2 in a potentially DR3‐dependent manner in the process of TAM apoptosis. Collectively, our findings provide new insights into the basic mechanisms underlying the actions of VEGI‐251 that might lead to future development of antitumour therapeutic strategies using VEGI‐251 to target TAMs.

Microporous metal-organic frameworks (MOFs) are promising candidate materials for chemical sensing, but the reproducible fabrication of MOF-based sensors with optimized and stable performances remains a significant challenge. Here, we report the fabrication of MOF optical sensors with steady but tunable optical properties via assembling UiO-66 crystals with controllable sizes and missing-linker defects. The well-defined but tunable microscopic and mesoscopic structural features of MOF sensing components greatly facilitate the optimization of device performance. The UiO-66 crystal-assembled sensors display fast response (2.00 s) and short recovery (3.00 s) to ethanol vapor (one of the analytes we tested). Our systematical investigation indicates that the mesoporous features of sensing components contribute greatly to the enhanced sensitivity (by ∼24.6% to the saturated ethanol vapor), response speed (by ∼42.9%), and recovery speed (by ∼59.7%) of the crystal-assembled sensors in comparison to their dense counterpart. The building crystal sizes show a slight influence on the response speed but profound effects on the sensitivity and recovery performances of sensors. The missing-linker defects have obvious beneficial effects on the desorption kinetics of analyte and can cause a faster recovery of sensors.

The rapidly emerging human health crisis associated with the Zika virus (ZIKV) epidemic and its link to severe complications highlights the growing need to identify the mechanisms by which ZIKV accesses hosts. Interferon response protects host cells against viral infection, while the cellular factors that mediate this defense are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have been identified, only a few have been characterized for their antiviral potential, target specificity and mechanisms of action. In this work, we focused our investigation on the possible antiviral effect of a novel ISG, C19orf66 in response to ZIKV infection and the associated mechanisms. We found that ZIKV infection could induce C19orf66 expression in ZIKV-permissive cells, and such an overexpression of C19orf66 remarkably suppressed ZIKV replication. Conversely, the depletion of C19orf66 led to a significant increase in viral replication. Furthermore, C19orf66 was found to interact and co-localize with ZIKV nonstructural protein 3 (NS3), thus inducing NS3 degradation via a lysosome-dependent pathway. Taken together, this study identified C19orf66 as a novel ISG that exerts antiviral effects against ZIKV by specifically degrading a viral nonstructural protein. These findings uncovered an intriguing mechanism of C19orf66 that targeting NS3 protein of ZIKV, providing clues for understanding the actions of innate immunity, and affording the possible availability of new drug targets that can be used for therapeutic intervention., Author summary ZIKV represents a serious threat to global health with particular relevance to microcephaly and other congenital abnormalities in newborns, and Guillain-Barré syndrome, meningoencephalitis, multi-organ failure in adults. Despite the global health threat of Zika virus infection, there is currently no vaccine or effective antiviral therapy available for the disease. As widely recognized, interferon signaling is key to establishing a strong antiviral state in host cells, mainly mediated through the anti-viral effects of numerous interferon-stimulated genes (ISGs). This work described our novel finding of the antiviral effect of a novel ISG, C19orf66, and its underlying mechanisms. We identified C19orf66 as a novel ISG that exerts antiviral effects against ZIKV by specifically interacting and colocalizing with the ZIKV nonstructural (NS) protein NS3, which inducing NS3 degradation via a lysosome-dependent pathway. Thus, this work broadens the understanding of the pivotal roles of C19orf66 in the interaction between the host and ZIKV, which might further provide a rational basis for developing novel anti-ZIKV strategies.

We report on a controlled synthesis of uniform MOF-5 sheets. The MOF sheets were solvothermally synthesized in a basic reaction medium in the presence of polyvinylpyrrolidone (PVP). Systematical investigation on the synthetic parameters revealed a pH-modulated mechanism for the formation of sheet-like morphology of MOF-5 crystals and a PVP-promoted shape evolution of the well-defined square sheets with uniform length and thickness.

Processing metal-organic frameworks (MOFs) as films with controllable thickness on a substrate is increasingly crucial for many applications to realize function integration and performance optimization. Herein, we report a facile cathodic deposition process that enables the large-area preparation of uniform films of zeolitic imidazolate frameworks (ZIF-8, ZIF-71, and ZIF-67) with highly tunable thickness ranging from approximately 24 nm to hundreds of nanometers. Importantly, this oxygen-reduction-triggered cathodic deposition does not lead to the plating of reduced metals (Zn and Co). It is also operable cost-effectively in the absence of supporting electrolyte and facilitates the construction of well-defined sub-micrometer-sized heterogeneous structures within ZIF films.

The excitation and speed control of marine diesel engine plays an important role in the stability of marine power station system. In order to verify the feasibility of a new type of controller used in the marine power station system, it is necessary to understand the working characteristics of the diesel generator set in the condition of switching and grid connection power generation. The paper firstly researched and established the nonlinear mathematical model of ship power system, and then based on the Hamilton energy theory, designed the nonlinear excitation controller of diesel speed coordination unit, finally achieved the ship power station simulation system related to passivity based controller based on Simulink simulation platform. The simulation results show that the passivity based controller can keep the stability of the system in the process of no-load start-up, load sudden change and grid connection power generation and it has a certain value in engineering applications.