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In this study, Eu2+/Al3+-, Eu2+/Tb3+-, and Eu2+/Tb3+/Al3+-doped high silica glasses were prepared, and the effect of Al3+ on the spectroscopic properties of Eu2+ and Tb3+ and the energy transfer of Eu2+→Tb3+ was investigated. The results revealed that the addition of Al3+ increased the luminescent intensity of the Eu2+-doped glass by approximately 400 times. An obvious Eu2+→Tb3+ energy transfer occurred in the Eu2+/Tb3+-doped high silica glass, whose transfer efficiency can reached 66.9%. However, the efficiency continuously decreased as the Al3+ concentration increased, and eventually, it dropped to 7.2%. These phenomena can be explained by the following: Al3+ not only disperses Eu2+ but also changes the field strength and symmetry of its neighboring environment, thus increasing its emission intensity. Moreover, Al3+ destroys the strong dipole–dipole interactions between Eu2+ and Tb3+ in high silica glass due to its dispersive ability, which inhibits the energy transfer of Eu2+→Tb3+. This indicates that a small amount of Al3+ can significantly modify the neighboring environment of Eu2+ and change its light-emitting characteristics, potentially yielding efficient blue and green phosphors excited by near-ultraviolet light for use in white light-emitting diodes.

To study the clinical features and power spectral entropy (PSE) of electroencephalography signals in Wilson's disease (WD) patients with dystonia.Several scale evaluations were performed to assess the clinical features of WD patients. Demographic information and electroencephalography signals were obtained in all subjects.34 WD patients with dystonia were recruited in the case group and 24 patients without dystonia were recruited in the control group. 20 healthy individuals were included in the healthy control group. The mean body mass index (BMI) in the case group was significantly lower than that in the controls (p .05). The case group had significantly higher SAS, SDS, and Bucco-Facial-Apraxia Assessment scores (p .05). Total BADS scores in the case group were lower than those in the control group (p .01). Note that 94.11% of the case group presented with dysarthria and 70.59% of them suffered from dysphagia. Dysphagia was mainly related to the oral preparatory stage and oral stage. Mean power spectral entropy (PSE) values in the case group were significantly different (p .05) from those in the control group and the healthy group across the different tasks.The patients with dystonia were usually accompanied with low BMI, anxiety, depression, apraxia, executive dysfunction, dysarthria and dysphagia. The cortical activities of the WD patients with dystonia seemed to be more chaotic during the eyes-closed and reading tasks but lower during the swallowing stages than those in the control group.

In order to improve the technology based on the existing animation scene stitching modeling, the animation scene stitching modeling is further studied combined with Laplacian equation. The algorithm uses wavelet transform to decompose the animation scene, and then obtains the low-frequency coefficients and high-frequency coefficients of the animation scene; For the high-frequency coefficients, the splicing rules based on the comparison and screening of the convolution results of two Laplacian template operators are adopted; For the low-frequency coefficients, the splicing rule based on Laplace sharpness evaluation function and 8-neighborhood local variance is adopted; Finally, the inverse wavelet transform is used to obtain the diffuse scene mosaic modeling. The experimental results are analyzed combined with subjective and various objective evaluation methods. The results show that the improved algorithm has better splicing effect than the traditional splicing modeling. Animation scene splicing modeling has the advantages of rich edge information and high scene definition.

Based on the Boltzmann distribution and multi-phonon relaxation probability criterion, an original Yb3+ population equation was proposed to describe the population distribution before and after laser generation, and the population distribution of Yb3+ under different pump ratios and temperatures was investigated by numerical simulation. The simulation results indicated that the laser wavelength of Yb3+-doped modified phosphate fibers have a high probability of being in the range of 1019 nm--1056 nm under the conventional pump ratio. Additionally, fibers lasing at a longer wavelength may have a lower laser threshold. For ultra-high pump ratio or high fiber temperature, the laser operation state changes from a quasi-four-level to a quasi-three-level scheme, and the laser wavelength may blue-shift. Experimental results verify the above simulation results, and in addition demonstrate an output power of 9.38 W with a slop efficiency of 27.4% in an Yb3+-doped phosphate modified fiber with a length of 35.4 cm and diameter of 280 μm from an optical path with a refrigeration patch and suppressing short-wave laser output. The results show that the laser performance of Yb3+-doped fibers can be improved by reducing the operating temperature and inhibiting short-wave laser output.

Nd3+-doped three-level (4F3/2–4I9/2) fiber lasers with wavelengths in the range of 850–950 nm are of considerable interest in applications such as bio-medical imaging and blue and ultraviolet laser generation. Although the design of a suitable fiber geometry has enhanced the laser performance by suppressing the competitive four-level (4F3/2–4I11/2) transition at ∼1 µm, efficient operation of Nd3+-doped three-level fiber lasers still remains a challenge. In this study, taking a developed Nd3+-doped silicate glass single-mode fiber as gain medium, we demonstrate efficient three-level continuous-wave lasers and passively mode-locked lasers with a gigahertz (GHz) fundamental repetition rate. The fiber is designed using the rod-in-tube method and has a core diameter of 4 µm with a numerical aperture of 0.14. In a short 4.5-cm-long Nd3+-doped silicate fiber, all-fiber CW lasing in the range of 890 to 915 nm with a signal-to-noise ratio (SNR) greater than 49 dB is achieved. Especially, the laser slope efficiency reaches 31.7% at 910 nm. Furthermore, a centimeter-scale ultrashort passively mode-locked laser cavity is constructed and ultrashort pulse at 920 nm with a highest GHz fundamental repetition is successfully demonstrated. Our results confirm that Nd3+-doped silicate fiber could be an alternative gain medium for efficient three-level laser operation.

A novel and effective method to improve scintillation properties of glass-ceramics, such as intensity enhancement and decay-time shortening, is reported in this work. Compared with crystal scintillators, glass scintillators always have the problems of low efficiency and long decay; how to solve them has always been a scientific puzzle in the field of scintillation glass-ceramics. The plasma enhancement effect can be predicted to solve the above problems. Ag

Transparent nanocrystalline glass with Eu:SnO2 is synthesized successfully by a modified porous glass sintering technology. As confirmed by High-resolution TEM (HRTEM) analyses, Eu ions are completely concentrated in SnO2 crystal particles rather than uniformly distributed in the amorphous matrix. The differences between Eu single-doped, Eu/SnO2 co-doped, and Eu:SnO2 doped glasses in X-ray diffraction (XRD) patterns, transmission spectra, and photoluminescence spectra are discussed in detail. The local environment that Eu3+ is in, as well as the host-to-activator energy transfer mechanism, is analyzed. Furthermore, the role of SnO2 in inhibiting Eu3+ reduction reaction and enhancing luminescence intensity is proved. This study not only demonstrates a simple way to fabricate pure Eu:SnO2-doped nanocrystalline silica glass but also further extends the applications of semiconductor oxide nanocrystals in the field of gain materials.

Active DNA demethylation process critically relies on the intrinsic properties of ten-eleven translocation proteins (Tets), particularly the flanking sequence preference. Challenged by the fact that the proximate bases to the 5-methylcytosine (5mC) are multitudinous and their influence on the Tets/DNA interplay is minute, the current methodologies are very limited in terms of cost, sensitivity and efficiency. Herein, we propose a polymerization retardation isothermal amplification (PRIA) strategy that enables sensitive and fast study of the flanking sequence preference of Tet. By arranging DNA polymerase to repetitively pass DNA strands through an isothermal replication-scission amplification reaction, the tiny difference in the Tet/DNA interplay can be consecutively accumulated and amplified. Low amount sample (80 ng) even multiple samples can be simultaneously analyzed within 10 h on an easily accessible laboratory real-time quantitative PCR instrument. For a proof-of-concept study, the binding preference (PB) of Tet2 for XmCGX, (X = C, G, T, A) was analyzed by PRIA and computational analysis, showing an order of AmCGT > TmCGA ≈ GmCGC > CmCGG. Furthermore, the binding and oxidation preference in Tet/DNA interplay process was individually considered. By comparative evaluation of the total flanking sequence preference (PT) and the PB, for the first time, we revealed that Tet2 has a lower oxidation preference (PO) to proximal flanking bases and the main contributor to PT of Tet2 is PB. The PRIA strategy, due to its reliable, cost-effective, high efficiency and low sample input, would hopefully advance epigenetic researches and other relative studies.

An effective method of improving the luminescent properties of rare earth ions in fluoride glasses were reported. The Pr3+/Ho3+ co-doped fluorochlorozirconate luminescent glasses were prepared, and the effects of chloride on the spectral properties and structure of the glasses were studied. According to the results, the glass stability is improved, and the luminescence intensity in the visible range is significantly enhanced with the introduction of chloride. By introducing 7.5 mol% BaCl2, the luminescence intensity reaches the maximum and increases by three times. The mechanism of luminescence enhancement is explained by analyzing the correlation between the composition and the structure. The chloride ions disperse outside the glass network before the introduction of 7.5 mol% BaCl2 and increased dispersity of Pr3+ and Ho3+ ions in the fluorozirconate glasses.

In this study, a series of novel tryptanthrin derivatives were synthesized and their inhibitory activities against selected human cancer cell lines, namely, lung (A549), chronic myeloid leukemia (K562), prostate (PC3), and live (HepG2), were evaluated using a methyl thiazolyl tetrazolium colorimetric (MTT) assay. Among the tested compounds, compound C1 exhibited a promising inhibitory effect on the A549 cell line with an IC50 value of 0.55 ± 0.33 µM. The observation of the cell morphological result showed that treatment with C1 could significantly inhibit the migration of A549 cells through the cell migration assay. Moreover, after treatment with C1, the A549 cells exhibited a typical apoptotic morphology and obvious autophagy. In addition, the detection of apoptosis and the mitochondrial membrane potential indicated that C1 induced A549 cell apoptosis via modulating the levels of Bcl2 family members and disrupted the mitochondrial membrane potential. Compound C1 also suppressed the expression of cyclin D1 and increased the expression of p21 in the A549 cells, inducing cell cycle arrest in the G2/M phase in a dose dependent manner. The further mechanism study found that C1 markedly increased the transformation from LC3-I to LC3-II. Taken together, our results suggest that C1 is capable of inhibiting the proliferation of non-small cell lung cancer (NSCLC) cells, inducing cell apoptosis, and triggering autophagy.

In this study, YVO4:Nd nanocrystals embedded in sintered high-silica porous glass are synthesized. XRD and Raman spectroscopy analyses confirm that YVO4:Nd nanocrystals are dispersed in sintered high-silica glass, and the average size of the nanoparticles is 24 nm. Absorption, emission intensities, and radiation quantum efficiency of Nd3+ ions are obviously enhanced after crystallization. The stimulated emission cross-section of Nd3+ ions 4F3/2 → 4I11/2 transition reaches 5.2 × 10−20 cm2, which is the largest in silicate glasses.

Sensitive and accurate imaging of intracellular-specific microRNAs (miRNAs) in situ in living cells is seriously challenged by the susceptibility of nucleic acid probes and the low dynamics of the hybridization reaction in cellular environments. Herein, we engineer a set of new metastable dumbbell probes (M xDPs) to overcome these key limitations by concurrently boosting transfection, antidigestibility, assembly dynamics, and nanostructural uniformity. The M xDPs can maintain their stability up to 16 h in living cells and produce uniform and dense DNA nanostructures rapidly (

Metal-organic frameworks (MOFs) for enzyme immobilization have already shown superior tunable and designable characteristics, however, their diverse responsive properties have rarely been exploited. In this work we integrated a responsive MOF into a MOF-enzyme composite with the purpose of designing an "all-in-one" multifunctional composite with catalytic and luminescence functions incorporated into a single particle. As a proof-of-concept, glucose oxidase (GOx) was encapsulated in situ within an oxygen (O2 )-sensitive, noble-metal-free, luminescent CuI triazolate framework (MAF-2), denoted as GOx@MAF-2. Owing to the rigid scaffold of MAF-2 and confinement effect, the GOx@MAF-2 composite showed significantly improved stability (shelf life of 60 days and heat resistance up to 80 °C) as well as good selectivity and recyclability. More importantly, owing to the O2 sensitivity of MAF-2, the GOx@MAF-2 composite exhibited a rapid and reversible response towards dissolved O2 , thereby allowing direct and ratiometric sensing of glucose without the need for chromogenic substrates, cascade enzymatic reactions, or electrode systems. High sensitivity with a detection limit of 1.4 μm glucose was achieved, and the glucose levels in human sera were accurately determined. This strategy has led to a new application for MOFs that can be facilely extended to other MOF-enzyme composites due to the multifunctionality of MOFs.

Ce3+-doped oxyfluoride aluminosilicate glasses and glass ceramics were prepared by a melt-quenching method with subsequent heat treatment, and their spectral and scintillation properties were measured and analyzed. The effects of Na+ ions and glass microcrystallization on the spectral and scintillation properties are discussed. Although Na+ ions were favorable for the formation of glass, their photoluminescence and radioluminescence intensity were relatively low. After microcrystallization, the photoluminescence and radioluminescence intensities of the sodium-free oxyfluoride aluminosilicate glass ceramics increased by 2.3 and 4 times, respectively. Microcrystallization of glass is an effective method to improve the scintillation properties.

Germanium dioxide (GeO2)-doped phosphate glasses with large gain coefficient and systematical factor (SFL) were prepared by high temperature melting for laser glass applications. Their physical parameters and optical properties were investigated such as glass transition temperature (Tg), density, Raman spectra, fluorescence emission spectra, decay cure and absorption spectra. Compared with the traditional phosphate glass, the introduction of GeO2 to phosphate glass results in a high fluorescent intensity and a long lifetime. All these advantages might mean that GeO2-doped phosphate glasses are a promising candidate as a gain medium for ultra-fast and high-power laser.

Objective Thymopentin (5TP) significantly improved typical murine premature ovarian failure (POF) symptoms induced by a high‐fat and high‐sugar (HFHS) diet. However, its effect and mechanism remain unclear. Materials and methods RNA‐Seq was used to detect the differentially expressed genes among each group. HFHS‐induced POF mouse model was generated and injected with siRNA using Poly (lactic‐co‐glycolic acid) (PLGA) as a carrier. Results RNA‐Seq suggested that 5TP promoted the expression of Yin Yang 2 (YY2) in mouse ovarian granulosa cell (mOGC) of HFHS‐POF mice. Luciferase reporter assay indicated that 5TP promoted the binding of YY2 to the specific sequence C(C/T)AT(G/C)(G/T) on the Lin28A promoter and promoted Lin28A transcription and expression. We continuously injected PLGA‐cross‐linked siRNA nanoparticles targeting YY2 into HFHS‐POF mice (siYY2@PLGA), which significantly reduced the therapeutic effect of 5TP. siYY2@PLGA injection also significantly attenuated the upregulation of Lin28a expression in mOGCs induced by 5TP and enhanced the expression of let‐7 family microRNAs, thereby inhibiting the proliferation and division of mOGCs. qPCR results showed that there was a significant difference in the expression levels of exosome‐derived Yy2 mRNAs between POF patients and normal women, and that there was a specific correlation between the expression level of exosome‐derived Yy2 and the peripheral concentrations of the blood hormones pregnenolone, progesterone and oestradiol. Conclusions Thymopentin promotes the transcriptional activation of Lin28A via stimulating transcription factor YY2 expression, inhibits the activity of let‐7 family microRNAs and alleviates the ageing of ovarian granulosa cells, ultimately achieving a therapeutic effect on POF in mice., Thymopentin promotes the transcriptional activation of Lin28A via stimulating transcription factor YY2 expression, inhibit the activity of let‐7 family microRNAs, and alleviate the aging of ovarian granulosa cells, ultimately achieving a therapeutic effect on POF in mice.

5-Hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) are key intermediates of active DNA demethylation, for which the global detection methods are still restricted by high cost and long operation time. Here, we demonstrate a pearl necklacelike strategy to accurately quantify global 5hmC and 5fC in genomic DNA. In this method, the metal-organic framework (MOF), [Cu3(BTC)2] (denoted as HKUST-1, H3BTC = 1,3,5-benzenetricarboxylic acid), with a diameter of ∼30 nm that contains ∼15 000 copper ions (Cu2+) as the "super label" was in situ grown in the carboxylated 5hmC and 5fC loci of genomic DNA via the coordination between Cu2+ and the carboxyl group. After the acid digestion of MOF, the concentration of Cu2+, which has a quantitative relationship with the 5hmC/5fC content, was measured by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). The metal element enrichment during MOF growth has amplified the signal by 4 orders of magnitude, realizing sensitive and accurate quantification of global 5hmC and 5fC in different tissues with a detection limit of 0.031% and 0.019‰ in DNA, respectively. The bisulfite- and mass spectrometry-free strategy is easily performed in almost all research and medical laboratories and would provide potential capability to quantify other candidate modifications in nucleotides.

In situ analysis of tumor-related messenger RNAs (mRNAs) is significant in identifying cancer cells at the genetic level in the early stage. Rolling circle amplification (RCA)-based methods are primary tools for in situ mRNA assay, however, the necessary ligation reaction not only shows low ligation efficiency, but also greatly prolongs the assay time that increases the risk of cells losing and mRNAs leakage. In this work, we propose a novel toehold-mediated ligation-free RCA (TMLFRCA) on a designed structure-switchable dumbbell-shaped probe (SDP). Target mRNA can specifically activate SDP from its circular form by toehold strand displacement, thereby initiates in situ RCA for mRNA imaging with the help of a short DNA primer. For the proof-of-concept demonstration, the TK1 mRNA was sensitively detected by TMLFRCA in less than 3.5 h with a limit of detection (LOD) of 0.39 fM (corresponds to 2.39 × 10 8 c o p i e s L − 1 ), and significantly improved specificity capable for distinguishing single base difference. The sensitivity of the TMLFRCA for TK1 mRNA in situ assay is ∼29-fold and ∼7-fold higher than that of FISH and ligase-assisted RCA method, respectively, which enables the TMLFRCA method capability of highly sensitive and specific distinction mRNA expression levels between cancer cells and normal cells. We believe this TMLFRCA strategy would be of great value in both basic research and clinical diagnosis.

Yb3+, Yb3+/Al3+, and Yb3+/P5+ co-doped silica glasses, as well as pure silica, Al3+, and P5+ single-doped silica glasses, were prepared using a sol–gel method combined with high-temperature sintering. The glasses were irradiated with a 193 nm ArF excimer laser for different durations. The species of the 193 nm laser-induced color centers were identified by radiation-induced absorption (RIA), in-situ photoluminescence (PL), and continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopic techniques. To obtain the RIA and CW-EPR characteristics of each color center, the Gaussian decomposition of RIA and the line-shape simulation of the CW-EPR spectra were performed. The formation mechanism of the color centers was correlated with the glass microscopic structure, which was obtained by nuclear magnetic resonance (NMR) spectroscopy. The results show that the oxygen hole center and the Yb2+ ion pairs are primarily responsible for the radiation-induced darkening, and their formation is highly dependent on the charge balance between the Yb3+ ion and its ligand. This work provides insights into the underlying mechanism of pump light and/or external radiation-induced optical losses in Yb3+-doped silica fibers.

Purpose: To specify the functional requirements of different FPG mobile game users, improve the game experience of users, optimize the mobile game functions, and contribute to the focused design and optimization by the mobile game developers in the product development process. Method: Firstly, nine functional requirements are determined through literature review and pre-questionnaire data; then, KANO model and Bart classification method are used to summarize the KANO questionnaire survey results. Conclusions: The functional requirements of four types of FPS mobile games users are concluded and sequenced; the design principles are proposed, and the functional requirement model for four types of FPS mobile game users is constructed while the feasibility of the theory and results is reversely tested by the concept of design practices.

The effects of preparation atmosphere on the formation and Photochromic properties of Al2O3 -CaO system glass were investigated. A reducing atmosphere was conducive to the formation of glasses with high Al contents, whereas an air atmosphere was favorable for the formation of glasses with low Al contents. Glasses fabricated under a reducing atmosphere exhibited a higher darkening degree than those fabricated under an air atmosphere, and their darkening degree increased with increasing Al content. The optimal irradiation wavelength for darkening was approximately 250 nm. The darkening faded slowly at room temperature and rapidly after heat treatment at above 200 °C. Moreover, the darkened glass faded completely after irradiation with blue-violet light (wavelength of 390–410 nm) for 10 min. A photochromic mechanism was suggested based on the results of absorption spectrum and electron spin resonance.

In this paper, the surface corrosion mechanisms of Chinese high-peak-power laser glass, the N31 glass, are investigated. Powder samples were immersed in deionized water for up to 72 days. The concentrations of ions in leachate solutions were measured by inductively coupled plasma optical emission spectroscopy, and the surface evolution during corrosion was characterized by X-ray photoelectron and attenuated total reflection infrared spectroscopies. The N31 glass leaches incongruently, and the normalized ionic release rate decreases with an increase of cation field strength. Depending on the oxygen-to‑phosphorus molar ratio (O/P ratio) evolution on the glass surface, the surface corrosion process presents two stages, which can be indirectly supported by the attenuated total reflection infrared spectroscopy results. This study reveals composition and structure evolutions on the glass surface during water corrosion. In addition, our results suggest that the O/P ratio on glass surface could be used to characterize the surface corrosion degree and mechanisms.

Active DNA demethylation, mediated by O2-dependent ten–eleven translocation (TET) enzymes, has essential roles in regulating gene expression. TET kinetics assay is vital for revealing mechanisms of demethylation process. Here, by a metal–organic framework (MOF)-based optical O2 sensor, we present the first demonstration on real-time TET2 kinetics assay in vitro. A series of luminescent Cu(I) dialkyl-1,2,4-triazolate MOFs were synthesized, which were noble-metal-free and able to intuitively response to dissolved O2 in a wide range from cellular hypoxia (≤15 μM) to ambient condition (∼257 μM). By further immobilization of the MOFs onto transparent silicon rubber (MOF@SR) to construct O2 film sensors, and real-time monitoring of O2 consumption on MOF@SR over the reaction time, the complete TET2-mediated 5-methylcytosine (5mC) oxidation process were achieved. The method overcomes the limitations of the current off-line methods by considerably shortening the analytical time from 0.5–18 h to 10 min, and remarka...

We report a 40 μm core-diameter single-mode multitrench fiber (MTF) based on Nd-doped silicate glass. Both the delocalization effect and leaky nature were considered in the design of the MTF. The silicate MTF was designed and fabricated using the rod-in-tube method. A maximum laser output power of ∼8.4 W with a slope efficiency of 54% was obtained from a 10-cm-long single-mode MTF.

A simple electrochemical strategy is reported for continuous monitoring of dynamic DNA methylation process over time. An electrochemical sensor was prepared by co-assembling of DNA probe and 6-mercapto-1-hexanol onto a gold electrode. The top of the DNA probe was labeled with 6-ferrocenylhexanethiol modified gold nanoparticle. The charge density between the C•G base pair was verified to be slightly reduced by DNA methylation, and could be further decelerated by ~ 25% upon co-locating a Br group onto methylated cytosine (mC). Therefore, in the presence of NaIO4/LiBr, the progressively methylated DNA on the sensor showed a clearly decreasing current over methylation time. The dynamic DNA methylation process was indicated continuously from the current decrease ratio, with a limit of detection of 0.0372µM. The strategy is convenient, cost-effective, and enable continuous profiling methylation process without distortion. Besides, the strategy was successfully applied for the studies on inhibitor screening and flanking sequence preference of DNA methyltransferase 3a. The results show that the activity of DNA methyltransferase 3a can be mildly inhibited by epigallocatechin gallate, and varies towards different flanking sequence with an order of 5'-CCGG-3' < 5'-CGCG-3' < 5'-CGCA-3'.

Highly Yb-doped silica glass with low refractive index for fabrication of Yb-doped large-mode-area photonic crystal fiber (LMA PCF) is in favor of decreasing fiber length and thus increasing the threshold of nonlinear effects in pulse laser amplification. Accordingly, fluorine incorporation in highly Yb-doped silica glass is vitally important to compensate the sharp increase in refractive index caused by ytterbium and aluminum ions. In this work, the fluorine doping concentration in Yb/Al/P/F co-doped silica glass was significantly improved by a modified sol-gel method combined with high temperature sintering. The effects of fluorine doping on glass structure have been investigated in details by Raman spectra, nuclear magnetic resonance (NMR) and advanced pulse electron paramagnetic resonance (EPR) measurements. The incorporation of fluorine yields Si-F bonds and Yb-F bonds formation and leads to the mild change in spectroscopic properties. An optimized silica core glass rod with high Yb (0.77 wt.%) and fluorine (0.8 wt.%) doping concentration, low refractive index and acceptable optical quality was prepared. Based on the highly fluorine and ytterbium doped silica core glass, a polarization maintaining (PM) photonic crystal fiber with 40 µm core was prepared and the pump absorption coefficient at 976 nm was ∼6.5 dB/m. An average amplified power of 103 W was achieved from a 2-m-long PCF with the bend diameter of 23 cm. The slope efficiency (with respect to pump power) was 52% with laser beam quality factor M2 of 1.46.

A fiber preform was attempted to prepare by the stacking method. After drawing and heat-treatment, a composite fiber with good stability was obtained using the CsPbBr3 glass ceramic as the core and the phosphate glass as the cladding. The formation of CsPbBr3 quantum dots in fibers was confirmed by Raman spectra. The results of the spectral testing indicated that the emission band of fibers after heat-treatment had the same red-shift as that of CsPbBr3 glass ceramics, but the emission peak wavelengths of the former were shorter than that of the latter. Moreover, as the length of fibers increased, the emission peak wavelength also was red-shifted. However, with the increase of heat-treatment temperature, the red-shift value of the emission peak wavelength of fibers became small as the length augmented. Due to the high loss of fibers near 520 nm, the result of laser amplification was not observed, which reflects that the preparation of fibers with short-wavelength lasers is still a challenge.