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1. Endovascular thrombectomy for acute ischaemic stroke with established large infarct (TENSION): 12-month outcomes of a multicentre, open-label, randomised trial

Author

Aamodt, Anne Hege, Adamczewski, Olaf, Alektoror, Kirill, Alexander, März, Alexandrou, Maria, Alias, Quentin, Al-Kuzae, Fadha Elawi, Allard, Julien, Al-Schameri, Rahman, Álvarez, Alberto, Andersen, Grethe, AnkerlundBlaufeldt, Rolf, Antje, Riedel, Appelbohm, Hannes, Argren, Maria, Assmann, Anne, Augustin, Michael, Bach, Elke, Bar, Michal, Barleben, Maria, Baronnet, Flore, Barrios, Andrés, Bavúzová, Xénia, BayThomsen, Rikke, Becker, Sandra, Beer, Sylvia, Behme, Daniel, Bellut, Maximilian, Bendszus, Martin, Berkefeld, Joachim, Bester, Maximillian, Bode, Felix J., Boehme, Christian, Boese, Ramona, Bohmann, Ferdinand, Bonekamp, Susanne, Borggrefe, Jan, Boss, Erendira Gabriela, Boutchakova, Maria, Boxhammer, Elfi, Brandhofe, Annemarie, Breckwoldt, Michael, Brekenfeld, Casper, Brehm, Alex, Brem, Christian, Breuer, Stella, Breyer, Tobias, Brodová, Petra, Broocks, Gabriel, Brosinski, Christoph, Bubel, Nele, Búřil, Jiří, Čábal, Martin, Casado, Laura, de Celis, Elena, Chabert, Emmanuel, Charisse, Daniel, Cheng, Bastian, Chovanec, Vendelín, Cidlinsky, Peter, Cisár, Juraj, Clarençon, Fréderic, Crozier, Sophie, Čurdová, Nina, Damaskinos, Michele, Damgaard, Dorte, Daniš, Martin, Dazinger, Florian, Deb-Chatterji, Milani, Delalic, Asima, Delekta, Agnieszka, Delorme, Stephen, Deutschmann, Hannes, Diamandis, Elie, Diedrichsen, Tove, Doležalová, Irena, Dorn, Franziska, du Mesnil de Rochemont, Richard, DupontHougaard, Kristina, Ebrahimi, Taraneh, Eff, Florian, Eliášová, Ilona, Enriquez, Brian, Ergawy, Mostafa, Essig, Fabian, Falkesgaard, Maiken, Fandler-Höfler, Simon, Fernández, Andrés, Ferré, Jean-Christophe, Ferrier, Anna, Fiehler, Jens, Figlewski, Krystian, Fischer, Sebastian, Fischer, Urs, Flottmann, Fabian, Forbrig, Robert, Förch, Christian, Fromm, Annette, Fuentes, Blanca, Gaedke, Ines, Galczak, Romana, Galijasevic, Malik, Ganser, Bernhard, Gattringer, Thomas, Gawlitza, Matthias, Gelhard, Sarah, Gellißen, Susanne, Gerber, Johannes, Giannakakis, Michail Panagiotis, Gindlhuber, Karin, Gizewski, Elke R., Glodny, Bernhard, Godel, Tim, Goebell, Einar, Goldemund, David, Görtler, Michael, Goyal, Mayank, Grams, Astrid E., Gruber, Joachim, Gruber, Katharina, Günthner-Lengsfeld, Thomas, Haase, Kathrin, Hacker-Ivan, Floriana, Hallerstig, Erika, Hametner, Christian, Hanning, Uta, Haring, Jozef, Haršány, Michal, Haršány, Ján, Hartmann, Christian, Hassler, Eva Maria, Hauptmann, Kristina, Haeusler, Karl Georg, Hecker, Constantin, Hellstern, Victoria, Henkes, Hans, Hernández, Victoria, Herweh, Christian, Hilgenfeld, Tim, Hill, Michael D., Hjort, Niels, HjortJensen, Nina, Hoelter, Maya, Hoffmann, Karl-Titus, Holst, Brigitte, Holtmannspoetter, Markus, Hopf-Jensen, Silke, Hoppe, Julia, Horner, Susanne, HougaardSoerensen, Leif, Hua, Vi Tuan, Hubert, Alexander, Hurtíková, Eva, Jakubíček, Stanislava, Janjic, Tanja, Jaramillo, Kirsten, Jedlitschka, Angela, Jensen, Schiela, Jensen, Märit, Jesser, Jessica, Jestaedt, Leonie, Johnson, Sabine, Jonszta, Tomáš, Kalmar, Peter, Karabegovic, Sanja, Karen, Kollo, Kastrup, Andreas, Katja, Hopp, Keeba, Natalia, Keese, Petra, Kefaloykos, Christina, Keil, Fee, Kellert, Lars, Kellinghaus, Christoph, Kestner, Roxane-Isabelle, Kiechl, Stefan, Killer-Oberpfalzer, Monika, Klepanec, Andrej, Knispel, Casjupea, Knoflach, Michael, Kohler, Sabine, Kohlhase, Konstantin, Kollikowski, Alexander Marco, Kovář, Martin, Krajina, Antonín, Kral, Michael, Krastev, Georgi, Krause, Lars Udo, Kreidenhuber, Rudolf, Křivka, Tomáš, Krkoška, Adam, Kröger, Jan Robert, Kronlage, Moritz, Krukowski, Pawel, Kühn, Julia, Kurča, Egon, Kurka, Natalia, Kuschnerow, Michael, Lachmund, Rita, Lamprecht, Susanne, Lange, Rüdiger, Lauer, Monika, de Leciñana, Alonso, Leder, Sara, Leger, Anne, Lehnen, Nils, Lehrieder, Dominik, Leißner, Maximilian, Leitinger, Markus, Leitner, Ursula, Lenck, Stéphanie, Lenzenweger, Eva, Liebig, Thomas, Lowens, Stephan, Lunzer, Manuel, Maegerlein, Christian, Magyar, Marton, Marques, Leonardo, Matyáš, David, Maurer, Gabriele, Mauritz, Matthias, Maximilian, Thormann, Mayer-Süß, Lukas, Meckel, Stephan, Medek, Oldřich, Meissner, Julius N., Mencl, Pavel, Merkle, Andrea, Mesche, Birte, Michalski, Dominik, Mikulík, Robert, Modrau, Boris, Möhlenbruch, Markus A., Mohr, Alexander, Mönninghoff, Christoph, Moser, Tobias, Mücke, Ramona, Müller-Hülsbeck, Stefan, Müller-Thies-Broussalis, Erasmia, Mutzenbach, Sebastian, Navia, Pedro, Neuberger, Ulf, Neugebauer, Hermann, Neumann, Jens, Nguyên, Anh, Niederkorn, Kurt, Nosál', Vladimír, Novobilský, Richard, Ntoulias, Nikos, Nussbaum, Lukas, Oder, Joanna, Oldag, Andreas, Ondrejkovič, Marián, Otto, Ferdinand, Otto, Dagmar, Paech, Daniel, Pagano, Paolo, Pallesen, Lars-Peder, Panský, Michal, Papanagiotou, Panagiotis, Patrick, Samp, Paukisch, Harald, Pelz, Johann, Petersen, Inga, Petersen, Martina, Petzold, Gabor C., Pfaff, Johannes, Pfeilschifter, Waltraud, Pham, Mirko, Pichler, Alexander, Pierot, Laurent, Pikija, Slaven, PlougmannPovlsen, Jan, Polkowski, Christoph, Polomac, Nenad, Portugaller, Rupert Horst, Poulsen, Marika, Preiß, Michael, Premat, Kévin, Prestsæter, Sjur, Prieto-Pérez, Rocio, Psychogios, Marios, Puetz, Volker, Purrucker, Jan, Rai, Heike, Rauch, Maximilian, Raupach, Jan, Reimann, Gernot, Reimann, Georg, Reitz, Sarah, Renc, Ondřej, Retzlaff, Jasmin, Rigual, Ricardo, Ringleb, Peter Arthur, Rivera-Bengoa, Carlota, Rodríguez, Jorge, Rohde, Stefan, Rohler, Siegfried, Rosso, Charlotte, Roth, Christian, Röttcher, Thomas, Roubec, Martin, Roztočilová, Milada, Rudnicka, Svetlana, Ruiz, Gerardo, Ryan, Stephen, Ryckborst, Karla J., Sandvik, Simen, Schäfer, Jan-Hendrik, Schaller-Paule, Martin, Schell, Maximillian, Schellinger, Peter, Schlemm, Eckhard, Schmid, Florian, Schmidt, Christoph, Schmitz, Marie Louise, Schneider, Claus, Scholtz, Jan-Erik, Schönenberger, Silvia, Schröter, Andreas, Schwarz, Daniel, Schwarz, Stephan, Schwarzenhofer, Daniel, Seifert-Held, Thomas, Seiler, Alexander, Seker, Fatih, Shotar, Eimad, Simonsen, Claus Z., Simonsen, Maria Theresa, Sivák, Jozef, Skagen, Karolina, Skjelland, Mona, Šnajdrová, Alena, Solymosi, Lazlo, Sømark, Jesper, Sonnberger, Michael, Soršák, Jakub, Sourour, Nader, Søyland, Jogrim, Spitzer, Daniel, Sporns, Peter, Städt, Michael, Steidl, Eike, Størdal, Anne Margrethe Kaalaas, Stösser, Sebastian, Strickmann, Sarah, Strýček, Ondřej, Suškevič, Igor, Sýkora, Jan, Tennøe, Bjørn, Thaler, Daniela, Theisen, Sara, Thomalla, Götz, Trendafilov, Petar, Trenkler, Johannes, Trumm, Christoph, Tsogkas, Ioannis, Tunold, Jon-Anders, Tveit, Lars, Ulfert, Christian, Vališ, Kateřina, Vaníček, Jiří, Vassilev, Christine, Vítková, Eva, Voit-Höhne, Heinz-Leonhard, Vojtíšek, Bohuslav, Volderauer, Karoline, Vollherbst, Dominik, Vollmuth, Christoph, Volna, Kamila, Volný, Ondřej, VonWeitzel-Mudersbach, Poul, Vorčák, Martin, Wagner, Marlies, Wathle, Gaute Kjellevold, Weber, Werner, Weber, Anushe, Weiss, Viktor, Weller, Johannes M., Wenger-Alakmeh, Katharina, Weyland, Cyrill, Weymayr, Friedrich, Wießpeiner, Ulrike, Willeit, Johannes, Wittwer, Aymeric, Wollenweber, Frank, Wortmann, Ginette, Wunderlich, Silke, Xiong, Yanyan, You, Se-Jong, ZachoSpeiser, Lasse, Zamani, Mahtab, Zelenak, Kamil, Zeleňáková, Jana, Zubel, Seraphine, Subtil, Fabien, Gizewski, Elke R, Hill, Michael D, Krajina, Antonin, Simonsen, Claus Z, Zeleňák, Kamil, Blauenfeldt, Rolf A, Denis, Angélique, Gerber, Johannes C, Keil, Christiane Fee, Mikkelsen, Ronni, Möhlenbruch, Markus, Münnich, Nico, Petzold, Gabor C, Schell, Maximilian, Vollherbst, Dominik F, and Wick, Wolfgang

Published
2024
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2. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial

Author

Aamodt, Anne Hege, Adamczewski, Olaf, Alektoror, Kirill, Alexander, März, Alexandrou, Maria, Alias, Quentin, Al-Kuzae, Fadha Elawi, Allard, Julien, Al-Schameri, Rahman, Álvarez, Alberto, Andersen, Grethe, AnkerlundBlaufeldt, Rolf, Antje, Riedel, Appelbohm, Hannes, Argren, Maria, Assmann, Anne, Augustin, Michael, Bach, Elke, Bar, Michal, Barleben, Maria, Baronnet, Flore, Barrios, Andrés, Bavúzová, Xénia, BayThomsen, Rikke, Becker, Sandra, Beer, Sylvia, Behme, Daniel, Bellut, Maximilian, Bendszus, Martin, Berkefeld, Joachim, Bester, Maximillian, Bode, Felix J., Boehme, Christian, Boese, Ramona, Bohmann, Ferdinand, Bonekamp, Susanne, Borggrefe, Jan, Boss, Erendira Gabriela, Boutchakova, Maria, Boxhammer, Elfi, Brandhofe, Annemarie, Breckwoldt, Michael, Brekenfeld, Casper, Brehm, Alex, Brem, Christian, Breuer, Stella, Breyer, Tobias, Brodová, Petra, Broocks, Gabriel, Brosinski, Christoph, Bubel, Nele, Búřil, Jiří, Čábal, Martin, Casado, Laura, Celis, Elena de, Chabert, Emmanuel, Charisse, Daniel, Cheng, Bastian, Chovanec, Vendelín, Cidlinsky, Peter, Cisár, Juraj, Clarençon, Fréderic, Crozier, Sophie, Čurdová, Nina, Damaskinos, Michele, Damgaard, Dorte, Daniš, Martin, Dazinger, Florian, Deb-Chatterji, Milani, Delalic, Asima, Delekta, Agnieszka, Delorme, Stephen, Deutschmann, Hannes, Diamandis, Elie, Diedrichsen, Tove, Doležalová, Irena, Dorn, Franziska, du Mesnil de Rochemont, Richard, DupontHougaard, Kristina, Ebrahimi, Taraneh, Eff, Florian, Eliášová, Ilona, Enriquez, Brian, Ergawy, Mostafa, Essig, Fabian, Falkesgaard, Maiken, Fandler-Höfler, Simon, Fernández, Andrés, Ferré, Jean-Christophe, Ferrier, Anna, Fiehler, Jens, Figlewski, Krystian, Fischer, Sebastian, Fischer, Urs, Flottmann, Fabian, Forbig, Robert, Förch, Christian, Fromm, Annette, Fuentes, Blanca, Gaedke, Ines, Galczak, Romana, Galijasevic, Malik, Ganser, Bernhard, Gattringer, Thomas, Gawlitza, Matthias, Gelhard, Sarah, Gellißen, Susanne, Gerber, Johannes, Giannakakis, Michail Panagiotis, Gindlhuber, Karin, Gizewski, Elke R., Glodny, Bernhard, Godel, Tim, Goebell, Einar, Goldemund, David, Görtler, Michael, Goyal, Mayank, Grams, Astrid E., Gruber, Joachim, Gruber, Katharina, Günthner-Lengsfeld, Thomas, Haase, Kathrin, Hacker-Ivan, Floriana, Hallerstig, Erika, Hanning, Uta, Haring, Jozef, Haršány, Michal, Haršány, Ján, Hartmann, Christian, Hassler, Eva Maria, Hauptmann, Kristina, Häusler, Karl Georg, Hecker, Constantin, Hellstern, Victoria, Henkes, Hans, Hernández, Victoria, Herweh, Christian, Hilgenfeld, Tim, Hill, Michael D., Hjort, Niels, HjortJensen, Nina, Hoelter, Maya, Hoffmann, Karl-Titus, Holst, Brigitte, Holtmannspoetter, Markus, Hopf-Jensen, Silke, Hoppe, Julia, Horner, Susanne, HougaardSoerensen, Leif, Hua, Vi Tuan, Hubert, Alexander, Hurtíková, Eva, Jakubíček, Stanislava, Janjic, Tanja, Jaramillo, Kirsten, Jedlitschka, Angela, Jensen, Schiela, Jensen, Märit, Jesser, Jessica, Jestaedt, Leonie, Johnson, Sabine, Jonszta, Tomáš, Kalmar, Peter, Karabegovic, Sanja, Karen, Kollo, Kastrup, Andreas, Katja, Hopp, Keeba, Natalia, Keese, Petra, Kefalaykos, Christina, Keil, Fee, Kellert, Lars, Kellinghaus, Christoph, Kestner, Roxane-Isabelle, Kiechl, Stefan, Killer-Oberpfalzer, Monika, Klepanec, Andrej, Knispel, Casjupea, Knoflach, Michael, Kohler, Sabine, Kohlhase, Konstantin, Kollikowski, Alexander Marco, Kovář, Martin, Krajina, Antonín, Kral, Michael, Krastev, Georgi, Krause, Lars Udo, Kreidenhuber, Rudolf, Křivka, Tomáš, Krkoška, Adam, Kröger, Jan Robert, Kronlage, Moritz, Krukowski, Pawel, Kühn, Julia, Kurča, Egon, Kurka, Natalia, Kuschnerow, Michael, Lachmund, Rita, Lamprecht, Susanne, Lange, Rüdiger, Lauer, Monika, Leciñana, Alonso de, Leder, Sara, Leger, Anne, Lehnen, Nils, Lehrieder, Dominik, Leißner, Maximilian, Leitinger, Markus, Leitner, Ursula, Lenck, Stéphanie, Lenzenweger, Eva, Liebig, Thomas, Lowens, Stephan, Lunzer, Manuel, Maegerlein, Christian, Magyar, Marton, Marques, Leonardo, Matyáš, David, Maurer, Gabriele, Mauritz, Matthias, Maximilian, Thormann, Mayer-Süß, Lukas, Meckel, Stephan, Medek, Oldřich, Meissner, Julius N., Mencl, Pavel, Merkle, Andrea, Mesche, Birte, Michalski, Dominik, Mikulík, Robert, Modrau, Boris, Möhlenbruch, Markus A., Mohr, Alexander, Mönninghoff, Christoph, Moser, Tobias, Mücke, Ramona, Müller-Hülsbeck, Stefan, Müller-Thies-Broussalis, Erasmia, Mutzenbach, Sebastian, Navia, Pedro, Neuberger, Ulf, Neugebauer, Hermann, Neumann, Jens, Nguyên, Anh, Niederkorn, Kurt, Nosál', Vladimír, Novobilský, Richard, Ntoulias, Nikos, Nussbaum, Lukas, Oder, Joanna, Oldag, Andreas, Ondrejkovič, Marián, Otto, Ferdinand, Otto, Dagmar, Paech, Daniel, Pagano, Paolo, Pallesen, Lars-Peder, Panský, Michal, Papanagiotou, Panagiotis, Patrick, Samp, Paukisch, Harald, Pelz, Johann, Petersen, Inga, Petersen, Martina, Petzold, Gabor C., Pfaff, Johannes, Pfeilschifter, Waltraud, Pham, Mirko, Pichler, Alexander, Pierot, Laurent, Pikija, Slaven, PlougmannPovlsen, Jan, Polkowski, Christoph, Polomac, Nenad, Portugaller, Rupert Horst, Poulsen, Marika, Preiß, Michael, Premat, Kévin, Prestsæter, Sjur, Prieto-Pérez, Rocio, Psychogios, Marios, Puetz, Volker, Purrucker, Jan, Rai, Heike, Rauch, Maximilian, Raupach, Jan, Reimann, Gernot, Reimann, Georg, Reitz, Sarah, Renc, Ondřej, Retzlaff, Jasmin, Rigual, Ricardo, Ringleb, Peter Arthur, Rivera-Bengoa, Carlota, Rodríguez, Jorge, Rohde, Stefan, Rohler, Siegfried, Rosso, Charlotte, Roth, Christian, Röttcher, Thomas, Roubec, Martin, Roztočilová, Milada, Rudnicka, Svetlana, Ruiz, Gerardo, Ryan, Stephen, Ryckborst, Karla J., Sandvik, Simen, Schäfer, Jan-Hendrik, Schaller-Paule, Martin, Schell, Maximillian, Schellinger, Peter, Schlemm, Eckhard, Schmid, Florian, Schmidt, Christoph, Schmitz, Marie Louise, Schneider, Claus, Scholtz, Jan-Erik, Schönenberger, Silvia, Schröter, Andreas, Schwarz, Daniel, Schwarz, Stephan, Schwarzenhofer, Daniel, Seifert-Held, Thomas, Seiler, Alexander, Seker, Fatih, Shotar, Eimad, Simonsen, Claus Z., Simonsen, Maria Theresa, Sivák, Jozef, Skagen, Karolina, Skjelland, Mona, Šnajdrová, Alena, Solymosi, Lazlo, Sømark, Jesper, Sonnberger, Michael, Soršák, Jakub, Sourour, Nader, Søyland, Jogrim, Spitzer, Daniel, Sporns, Peter, Städt, Michael, Steidl, Eike, Størdal, Anne Margrethe Kaalaas, Stösser, Sebastian, Strickmann, Sarah, Strýček, Ondřej, Suškevič, Igor, Sýkora, Jan, Tennøe, Bjørn, Thaler, Daniela, Theisen, Sara, Thomalla, Götz, Trendafilov, Petar, Trenkler, Johannes, Trumm, Christoph, Tsogkas, Ioannis, Tunold, Jon-Anders, Tveit, Lars, Ulfert, Christian, Vališ, Kateřina, Vaníček, Jiří, Vassilev, Christine, Vítková, Eva, Voit-Höhne, Heinz-Leonhard, Vojtíšek, Bohuslav, Volderauer, Karoline, Vollherbst, Dominik, Vollmuth, Christoph, Volna, Kamila, Volný, Ondřej, VonWeitzel-Mudersbach, Poul, Vorčák, Martin, Wagner, Marlies, Wathle, Gaute Kjellevold, Weber, Werner, Weber, Anushe, Weiss, Viktor, Weller, Johannes M., Wenger-Alakmeh, Katharina, Weyland, Cyrill, Weymayr, Friedrich, Wießpeiner, Ulrike, Willeit, Johannes, Wittwer, Aymeric, Wollenweber, Frank, Wortmann, Ginette, Wunderlich, Silke, Xiong, Yanyan, You, Se-Jong, ZachoSpeiser, Lasse, Zelenak, Kamil, Zeleňáková, Jana, Zubel, Seraphine, Subtil, Fabien, Gizewski, Elke R, Hill, Michael D, Krajina, Antonin, Simonsen, Claus Z, Zeleňák, Kamil, Blauenfeldt, Rolf A, Denis, Angélique, Gerber, Johannes C, Keil, Christiane Fee, Mikkelsen, Ronni, Möhlenbruch, Markus, Münnich, Nico, Petzold, Gabor C, Schell, Maximilian, Vollherbst, Dominik F, and Wick, Wolfgang

Published
2023
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4. Le paludisme aujourd’hui

Author

DANIS, Martin

Abstract

Malaria today Malaria, a parasitic disease the pathogen of which was discovered by Alphonse Laveran in 1880 in the blood of febrile patients, remains in 2022 the most frequent endemic disease in tropical and subtropical countries. In its latest “World Malaria Report” available in November 2021, the WHO deals in great detail with the data collected in the field in 2019-2020, their progression over the last 20 years, and the mea-sures to be taken to try to better control this life-threatening endemic. The number of malaria cases is estimated at 232 million in 2019 in 87 endemic countries, down from 245 million in 2000. The WHO African Region alone accounts for 94% of cases and the most frequent and severe infections due to Plasmodium falciparum species. If children under the age of 5 are not treated promptly, they can die. Globally, the number of malaria deaths declined steadily over the period 2000-2019, from 897,000 in 2000 to 568,000 in 2019, with nearly 95% of deaths occurring in 31 countries, primarily in sub-Saharan Africa. In other WHO regions, including Southeast Asia, malaria deaths decreased by 74%, with 35,000 deaths in 2000 compared to 9,000 in 2019. Malaria can be controlled worldwide, and possibly eradi-cated, if public information campaigns are strengthened and sufficient funds are made available. Le paludisme aujourd’hui Le paludisme, maladie parasitaire dont l’agent pathogène a été découvert par Alphonse Laveran en 1880 en Algérie dans le sang de patients fébriles, reste en 2022 l’endémie des pays tropicaux et subtropicaux la plus fréquente. Dans son dernier « Rapport sur le paludisme dans le monde » disponible en novembre 2021, l’OMS rend compte très en détail des données recueillies sur le terrain en 2019-2020, de leur évolution depuis 20 ans et des mesures à prendre pour tenter de mieux contrôler cette endémie meurtrière. Le nombre de cas de paludisme est estimé à 232 millions en 2019 dans 87 pays d’endémie palustre, soit une baisse par rapport aux 245 millions de 2000. La région Afrique de l’OMS représente à elle seule 94 % des cas et les infections dues à l’espèce Plasmodium falciparum les plus fréquentes et les plus graves. En l’absence de prise en charge rapide chez les enfants de moins de 5 ans, le décès est à craindre. Au niveau mondial, le nombre de décès dus au paludisme a baissé de façon régulière sur la période 2000-2019, passant de 897 000 en 2000 à 568 000 en 2019. Près de 95 % des décès ont été enregistrés dans 31 pays, essentiellement d’Afrique subsaharienne. Dans les autres régions OMS, Asie du Sud-Est en particulier, le nombre de décès dus au paludisme a diminué de 74 %, avec 35 000 décès en 2000 contre 9000 en 2019. Le contrôle du paludisme dans le monde, son éradication peut-être, sont envisageables, à condition de dynamiser des campagnes d’information grand public et d’arracher des financements considérables., MTSI, Vol. 3 No 2 (2023): MTSI-Revue

Published
2023
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9. Delayed-onset hemolytic anemia in patients with travel-associated severe malaria treated with artesunate, France, 2011-2013

Author

Jaureguiberry, Stephane, Thellier, Marc, Ndour, Papa Alioune, Ader, Flavie, Roussel, Camille, Sonneville, Romain, Mayaux, Julien, Matheron, Sophie, Angoulvant, Adela, Wyplosz, Benjamin, Rapp, Christophe, Pistone, Thierry, Lebrun-Vignes, Benedicte, Kendjo, Eric, Danis, Martin, Houze, Sandrine, Bricaire, Francois, Mazier, Dominique, Buffet, Pierre, and Caumes, Eric

Subjects
Hemoglobin, Malaria -- Care and treatment, Hemolytic anemia -- Care and treatment, Health, World Health Organization
Abstract

Intravenous (IV) artesunate has been the recommended first-line treatment for severe malaria worldwide since 2010 (1). Two large randomized trials showed a 35.0% reduction (from 22.0% to 15.0%) in death [...]

Published
2015
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10. Superiority of 3 Over 2 Doses of Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine for the Prevention of Malaria During Pregnancy in Mali: A Randomized Controlled Trial

Author

Maiga, Oumou M., Kayentao, Kassoum, Traoré, Boubacar T., Djimde, Abdoulaye, Traoré, Bouyagui, Diallo, Mouctar, Ongoiba, Aissata, Doumtabé, Didier, Doumbo, Safiatou, Traoré, Mamadou S., Dara, Antoine, Guindo, Oumar, Karim, Diawara M., Coulibaly, Siraman, Bougoudogo, Flabou, Kuile, Feiko O. ter, Danis, Martin, and Doumbo, Ogobara K.

Published
2011
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14. Severe imported plasmodium falciparum Malaria, France, 1996-2003

Author

Seringe, Elise, Thellier, Marc, Fontanet, Arnaud, Legros, Fabrice, Bouchaud, Olivier, Ancelle, Thierry, Kendjo, Eric, Houze, Sandrine, Bras, Jacques Le, Danis, Martin, and Durand, Remy

Subjects
Medical research -- Analysis, Hemoglobin -- Analysis, Travelers -- Analysis, Blood sugar -- Analysis, Malaria -- Risk factors -- Development and progression -- Analysis, Travel -- France -- Analysis, Medicine, Experimental -- Analysis, Financial disclosure -- Analysis, Continuing medical education -- Analysis, Drug resistance -- Risk factors -- Development and progression -- Analysis, Americans in foreign countries -- Analysis, Drugs -- International trade -- Analysis, Public health -- Analysis, Plasmodium falciparum -- Analysis, Health
Abstract

Each year, a growing number of persons from industrialized countries travel to developing countries. Among these millions of travelers, 20% to 70% report some illness associated with their travel and [...]

Published
2011
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15. Risk factors for imported fatal Plasmodium falciparum malaria, France, 1996-2003

Author

Legros, Fabrice, Bouchaud, Olivier, Ancelle, Thierry, Arnaud, Amandine, Cojean, Sandrine, Le Bras, Jacques, Danis, Martin, Fontanet, Arnaud, and Durand, Remy

Subjects
Malaria -- Risk factors, Plasmodium falciparum
Abstract

Plasmodium falciparum malaria is a serious health hazard for travelers to malaria-endemic areas and is often diagnosed on return to the country of residence. We conducted a retrospective study of [...]

Published
2007

17. Intravenous Artesunate for the Treatment of Severe Imported Malaria: Implementation, Efficacy, and Safety in 1391 Patients.

Author

Roussel, Camille, Ndour, Papa Alioune, Kendjo, Eric, Larréché, Sébastien, Taieb, Aida, Henry, Benoît, Lebrun-Vignes, Bénédicte, Chambrion, Charlotte, Argy, Nicolas, Houzé, Sandrine, Mouri, Oussama, Courtin, David, Angoulvant, Adela, Delacour, Hervé, Gay, Frédérick, Siriez, Jean-Yves, Danis, Martin, Bruneel, Fabrice, Bouchaud, Olivier, and Caumes, Eric

Subjects
DRUG therapy for malaria, DRUG efficacy, HIV-positive persons, OBESITY, INTRAVENOUS therapy, COMMUNICABLE diseases, SCIENTIFIC observation, GENETIC mutation, MISCARRIAGE, PREGNANT women, DISEASE incidence, RACE, SEVERITY of illness index, HUMAN services programs, MALARIA, TREATMENT failure, COMPARATIVE studies, ANEMIA, DESCRIPTIVE statistics, ARRHYTHMIA, HEMODIALYSIS, LONGITUDINAL method, EPIDEMIOLOGICAL research, HEMORRHAGE, EVALUATION
Abstract

Background Intravenous artesunate is the World Health Organization–recommended first-line treatment for severe malaria worldwide, but it is still not fully licensed in Europe. Observational studies documenting its safety and efficacy in imported malaria are thus essential. Methods We prospectively collected clinical and epidemiological features of 1391 artesunate-treated patients among 110 participant centers during the first 7 years (2011–2017) of a national program implemented by the French Drug Agency. Results Artesunate became the most frequent treatment for severe malaria in France, rising from 9.9% in 2011 to 71.4% in 2017. Mortality was estimated at 4.1%. Treatment failure was recorded in 27 patients, but mutations in the Kelch-13 gene were not observed. Main reported adverse events (AEs) were anemia (136 cases), cardiac events (24, including 20 episodes of conduction disorders and/or arrhythmia), and liver enzyme elevation (23). Mortality and AEs were similar in the general population and in people with human immunodeficiency virus, who were overweight, or were pregnant, but the only pregnant woman treated in the first trimester experimented a hemorrhagic miscarriage. The incidence of post-artesunate–delayed hemolysis (PADH) was 42.8% when specifically assessed in a 98-patient subgroup, but was not associated with fatal outcomes or sequelae. PADH was twice as frequent in patients of European compared with African origin. Conclusions Artesunate was rapidly deployed and displayed a robust clinical benefit in patients with severe imported malaria, despite a high frequency of mild to moderate PADH. Further explorations in the context of importation should assess outcomes during the first trimester of pregnancy and collect rare but potentially severe cardiac AEs. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Plasmodium falciparum-infected erythrocyte adhesion induces caspase activation and apoptosis in human endothelial cells. (Major Article)

Author

Pine, Paco, Vouldoukis, loannis, Kolb, Jean Pierro, Mahmoudi, Nassira, Desportes-Livage, Isabelle, Bricaire, Fracis, Danis, Martin, and Mazier, Dominique

Subjects
Communicable diseases -- Research, Apoptosis -- Physiological aspects, Plasmodium falciparum -- Physiological aspects, Erythrocytes -- Physiological aspects, Malaria -- Physiological aspects, Endothelium -- Physiological aspects, Health
Published
2003

26. Chagas disease, France

Author

Lescure, Francois-Xavier, Canestri, Ana, Melliez, Hugues, Jaureguiberry, Stephane, Develoux, Michel, Dorent, Richard, Guiard-Schmid, Jean-Baptiste, Bonnard, Philippe, Ajana, Faiza, Rolla, Valeria, Carlier, Yves, Gay, Frederick, Elghouzzi, Marie-Helene, Danis, Martin, and Pialoux, Gilles

Subjects
Chagas' disease -- Diagnosis, Chagas' disease -- Risk factors, Chagas' disease -- Care and treatment, Chagas' disease -- Research
Abstract

Chagas disease (CD) is endemic to Latin America; its prevalence is highest in Bolivia. CD is sometimes seen in the United States and Canada among migrants from Latin America, whereas [...]

Published
2008

27. Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base

Author

Danis Martin, Dodoo Alex NO, Touze Jean, Imbert Patrick, Bouchaud Olivier, and Legros Fabrice

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Halofantrine (HF) was considered an effective and safe treatment for multi-drug resistant falciparum malaria until 1993, when the first case of drug-associated death was reported. Since then, numerous studies have confirmed cardiac arrythmias, possibly fatal, in both adults and children. The aim of the study was to review fatal HF related cardiotoxicity. Methods In addition, to a systematic review of the literature, the authors have had access to the global safety database on possible HF related cardiotoxicity provided by GlaxoSmithKline. Results Thirty-five cases of fatal cardiotoxicity related to HF, including five children, were identified. Females (70%) and patients from developing countries (71%) were over-represented in this series. Seventy-four percent of the fatal events occurred within 24 hours of initial exposure to HF. Twenty six patients (74%) had at least one predisposing factor for severe cardiotoxicity, e.g., underlying cardiac disease, higher than recommended doses, or presence of a concomitant QT-lengthening drug. All (100%) of the paediatric cases had either a contraindication to HF or an improper dose was given. In six cases there was no malaria. Conclusion A distinction should be made between common but asymptomatic QT-interval prolongation and the much less common ventricular arrhythmias, such as torsades de pointes, which can be fatal and seem to occur in a very limited number of patients. The majority of reported cardiac events occurred either in patients with predisposing factors or with an improper dose. Therefore, in the rare situations in which HF is the only therapeutic option, it can still be given after carefully checking for contraindications, such as underlying cardiac disease, bradycardia, metabolic disorders, personal or family history of long QT-interval or concomitant use of another QT-prolonging drug (e.g., mefloquine), especially in females.

Published
2009
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29. Disseminated Penicillium marneffei infection associated with human immunodeficiency virus: a report of two cases and a review of 35 published cases

Author

Hilmarsdottir, Ingibjorg, Meynard, Jean L., Rogeaux, Olivier, Guermonprez, Geraldine, Datry, Annick, Katlama, Christine, Brucker, Gilles, Coutellier, Anne, Danis, Martin, and Gentilini, Marc

Subjects
HIV infection -- Complications, Mycoses -- Case studies, Health
Abstract

Penicillium marneffei infection should be suspected in any HIV patient who develops fever, skin lesions, lung disease and weight loss, and has a history of travel to southeast Asia. Penicillium marneffei is a fungus that is widespread in southeast Asia, and there have been almost 50 reported cases in southeast Asia in HIV patients as well as in healthy individuals. There have been several additional cases in HIV patients who have traveled to southeast Asia. The symptoms include fever, anemia, skin lesions, fluid in the lungs and an enlarged liver. The fungus probably enters the body through the respiratory tract, but can infiltrate other organs. It can be isolated from blood, bone marrow, skin scrapings and liver biopsies. It is usually treated with amphotericin B, ketoconazole or itraconazole.

Published
1993

30. Severe ImportedPlasmodium falciparumMalaria, France, 1996–2003

Author

Seringe, Elise, Thellier, Marc, Fontanet, Arnaud, Legros, Fabrice, Bouchaud, Olivier, Ancelle, Thierry, Kendjo, Eric, Houze, Sandrine, Le Bras, Jacques, Danis, Martin, and Durand, Rémy

Subjects
Male, Pediatrics, Epidemiology, vector-borne infections, lcsh:Medicine, Disease, Risk Factors, CME, Imported malaria, Malaria, Falciparum, Young adult, Child, Aged, 80 and over, Travel, biology, Middle Aged, Infectious Diseases, Child, Preschool, Population Surveillance, severe malaria, parasite, Chemoprophylaxis, Female, France, Developed country, Adult, Microbiology (medical), medicine.medical_specialty, Adolescent, Plasmodium falciparum, malaria, Article, lcsh:Infectious and parasitic diseases, Young Adult, parasitic diseases, medicine, Humans, lcsh:RC109-216, Severe Malaria, Aged, Retrospective Studies, business.industry, Research, lcsh:R, Infant, Newborn, Infant, Retrospective cohort study, medicine.disease, biology.organism_classification, business, Malaria
Abstract

Little is known about severe imported Plasmodium falciparum malaria in industrialized countries where the disease is not endemic because most studies have been case reports or have included

Published
2011

32. Médecine tropicale (6° Éd.)

Author

GENTILINI Marc, DANIS Martin, RICHARD LENOBLE Dominique, TOUZE Jean-Étienne, KEROUÉDAN Dominique, CAUMES Éric, BÉGUÉ Pierre, GENTILINI Marc, DANIS Martin, RICHARD LENOBLE Dominique, TOUZE Jean-Étienne, KEROUÉDAN Dominique, CAUMES Éric, and BÉGUÉ Pierre

Abstract

Depuis sa première parution il y a 40 ans, sous la direction de Marc Gentilini, Médecine tropicale a acquis une renommée internationale. Cette 6e édition, entièrement réactualisée et en couleurs, reste fidèle au concept original : offrir au lecteur le maximum de renseignements dans un style direct et didactique, reflet de la riche expérience des auteurs. La médecine tropicale se définit comme la prise en charge et le traitement des maladies survenant dans un environnement tropical ou subtropical. Cette pathologie, géographiquement déterminée, n'est pas limitée au Sud et se rencontre également au Nord du fait des migrations humaines, mais elle atteint avant tout les populations pauvres des pays en développement La première partie du livre dresse le panorama dans lequel elle s'inscrit à travers la géographie, la population mondiale, le développement de celle-ci, les aides internationales ou régionales. Cette vision globale est la condition indispensable pour comprendre les enjeux de santé des pays du Sud. Les parties suivantes sont consacrées à l'ensemble des maladies transmissibles, parasitoses, mycoses, maladies bactériennes et maladies virales rencontrées dans l'hémisphère austral. Mais aujourd'hui, les maladies non transmissibles prennent une place de plus en plus importante dans les pays en voie de développement où cancers, diabète, maladies respiratoires, affections cardiovasculaires, tendent à devenir, ensemble, les principales causes de mortalité. L'émergence de ces maladies s'ajoute aux affections traditionnelles qui diminuent en pourcentage mais guère en valeur absolue compte tenu de la poussée démographique. Elles revêtent souvent, à cause de l'environnement, des aspects originaux exposés pour chaque discipline (hématologie, cardiologie, pneumologie, etc.) : la symptomatologie, les traitements des maladies cosmopolites diffèrent non seulement du fait de leur localisation en zone tropicale mais aussi des difficultés d'accès aux traitements de qualité. Il en est de même pour la chirurgie, dont les singularités et les carences sont le reflet de la précarité en moyens matériels et humains. Une partie entière est consacrée à la pédiatrie : la population infantile, qui représente la moitié de la population des pays tropicaux, est prioritairement touchée par les conditions socio-économiques et environnementales défectueuses. La prévention des maladies tropicales est exposée à travers la vaccination, la lutte antivectorielle, l'assainissement, l'éducation sanitaire, les conseils aux voyageurs se rendant dans les pays tropicaux. L'ouvrage s'achève par une présentation de l'épidémiologie adaptée à la zone tropicale. Les études épidémiologiques permettent de planifier rigoureusement les actions de santé communautaire et de rentabiliser au mieux les moyens disponibles, mais elles se heurtent à des difficultés l

Published
2012

34. Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis.

Author

Ndour, Papa Alioune, Larréché, Sébastien, Mouri, Oussama, Argy, Nicolas, Gay, Frédérick, Roussel, Camille, Jauréguiberry, Stéphane, Perillaud, Claire, Langui, Dominique, Biligui, Sylvestre, Chartrel, Nathalie, Mérens, Audrey, Kendjo, Eric, Ghose, Aniruddha, Hassan, Md. Mahtab Uddin, Hossain, Md. Amir, Kingston, Hugh W. F., Plewes, Katherine, Dondorp, Arjen M., and Danis, Martin

Subjects
DRUG side effects, HEMOLYSIS & hemolysins, MALARIA treatment, ARTEMISININ, ANTIMALARIALS
Abstract

The article discusses the risk of developing post-artesunate delayed hemolysis (PADH) among patients who received artesunate drug, as treatment for malaria. It mentions the use of an optimizedmembrane permeabilization method for determining the risk of PADH among artesunate-treated malaria patients. It also notes on the development of a semiquantitative titration method for early diagnosis.

Published
2017
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