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Background: Chronic stress is associated with accelerated aging and poor health outcomes in older adults. According to the Transactional Model of Stress (TMS), distress is experienced when one perceives the stressor, or threat, to outweigh the ability to cope. The experience of distress is correlated with trait neuroticism, which is associated with greater perceptions of stress and stress reactivity, as well as a tendency to engage in maladaptive coping strategies. However, as individual personality traits do not act in isolation, this study aimed to investigate the moderating role of self-esteem in the relationship between neuroticism and distress using a TMS framework. Methods: A total of 201 healthy older adults (Mage = 68.65 years) completed questionnaires measuring self-esteem, neuroticism, perceived stress, and positive coping. Results: Greater neuroticism was significantly associated with less positive coping at low (b = −0.02, p < 0.001) and mean self-esteem levels (b = −0.01, p < 0.001), but not at high self-esteem levels (b = −0.01, p = 0.06). No moderating effect was found for perceived stress or overall distress. Conclusion: The results support the association between trait neuroticism and indices of stress and suggest a potential buffering effect of self-esteem in moderating the negative association between neuroticism and positive coping.

Objectives Perceived stress and adherence to a Mediterranean diet pattern have been identified as independent predictors of cognitive function in older adulthood; however, no studies to date have examined the interaction between perceived stress and diet adherence on cognitive health. This cross-sectional study investigated the synergistic effect of perceived stress and adherence to a Mediterranean diet pattern on cognitive function in 192 nondemented older adults aged 60–95 years. Method Participants completed a Food Frequency Questionnaire (FFQ) and the Perceived Stress Scale (PSS-10). Executive functioning was assessed using the Trail Making Test-Part B (TMT-B) and episodic memory was assessed using the immediate and delayed free recall subscales from the California Verbal Learning Test (CVLT-II). Results Moderation analyses revealed that higher perceived stress was associated with worse executive functioning at low levels of Mediterranean diet adherence (B = 1.75, SE = 0.67, p = .009), but not at moderate and high levels of Mediterranean diet adherence (ps > .05). Perceived stress was not associated with episodic memory, irrespective of Mediterranean diet adherence. Discussion Findings provide preliminary evidence that the association between higher perceived stress and poorer executive function may be dependent on diet intake. Additional research is needed to confirm these findings.

Allostatic load (AL) is a multisystemic index of biological wear and tear which is associated with poor health outcomes. In recent years, researchers have examined the association between dietary pattern intake and AL; however, no studies to date have examined the relationship between AL and consumption of a Mediterranean diet. Blood and urine samples were collected from 201 community-dwelling older adults who completed a Food Frequency Questionnaire (FFQ). A Mediterranean Diet Score (MDS) was calculated based on previous recommendations and a sex-based AL index was calculated using a count-based approach for 16 biomarkers associated with neuroendocrine, immune, cardiovascular, or metabolic function. It was hypothesized that a higher MDS would associate with lower AL, and that this association would be particularly robust for the immune and metabolic subcomponents of the AL index. In support of the study hypotheses, generalized linear models revealed a significant inverse relationship between MDS and AL (ß = -0.03, P = 0.037). Furthermore, higher MDS was significantly associated with lower immune (ß = -0.06, P = 0.38) and metabolic (ß = -0.05, P = 0.039) subsystem scores, but was not associated with cardiovascular or neuroendocrine subsystem scores. Exploratory analyses further showed that the association was more robust in male than female participants. The current findings are interpreted with caution given the study design and sample characteristics. However, these findings contribute to the literature supporting the Mediterranean diet as an important lifestyle behavior that may support healthy aging.

Early life adversity is consequential for poor cognitive health in mid to late-life. Early life adversity is associated with higher allostatic load, a biological indicator of physiological dysregulation due to cumulative wear-and-tear from chronic stress. Higher allostatic load is also associated with poorer cognitive function across the lifespan. To date, a paucity of research has examined allostatic load as a mechanism through which early life adversity impacts cognition in adulthood. Using cross-sectional data from the Midlife in the United States (MIDUS) Study, the objective of the current study was to investigate the mediating role of allostatic load in the relationship between early life adversity and cognitive performance (global cognition, episodic memory, executive function) among middle-aged and older adults without cognitive impairment (n = 1541, M

Early life adversity (ELA) is consequential for poor cognitive health in mid to late life. ELA is associated with higher allostatic load (AL), a biological indicator of physiological dysregulation due to cumulative wear-and-tear from chronic stress. Higher AL is also associated with poorer cognitive function across the lifespan. To date, however, a paucity of research has investigated AL as a mechanism through which ELA impacts cognition. Using cross-sectional data from the Midlife in the United States (MIDUS) Study, the objective of this study was to investigate the mediating role of AL in the relationship between ELA and cognitive performance (global cognition, episodic memory, executive function) among middle-aged and older adults without cognitive impairment (n=1541, mean age=53±12, 53% female). ELA, including physical, emotional, and sexual experiences, was measured retrospectively using the Childhood Trauma Questionnaire. AL was composed of 20 biomarker proxies of neuroendocrine, metabolic, inflammatory, and cardiovascular systems, stratified by sex. Cognitive performance was evaluated using a battery of neuropsychological tests from the Brief Test of Adult Cognition by Telephone. Controlling for age, education, and ethnicity, AL significantly mediated the relationship between ELA and global cognition (ß=-0.01,95%CI[-0.02,-0.003]) and executive function (ß=-0.01,95%CI[-0.02,-0.003]) such that higher ELA was associated with higher AL, and higher AL was associated with poorer global cognition and executive function. No such effects were found for episodic memory. Consistent with the biopsychosocial lifespan model of cognitive aging, findings suggest that ELA may become biologically embedded over time to negatively impact cognitive function in later adulthood in a domain-specific manner.

Stress exposure over the lifespan is robustly associated with accelerated cognitive decline in later life. Brain-derived neurotrophic factor (BDNF) is shown to regulate activity of the hypothalamic-pituitary-adrenal axis. The objective of this study was to evaluate the association betweenthe BDNF polymorphism and indices of stress among adults aged 50+. Community-dwelling middle-aged and older adults provided a blood sample for BDNF genotyping. Participants also sampled their saliva 5 times/day for 3 consecutive days for the measurement of diurnal cortisol and underwent the Trier Social Stress Test (TSST) for the measurement of stress reactivity. Among 121 adults aged 50–67 years (78% female; 89% Caucasian), 74 participants were Val/Val carriers and 47 carried 1 copy of the Met allele. Repeated-measures analyses did not reveal an association between BDNF genotype and diurnal salivary cortisol (p = 0.63); however, analyses revealed that Met+ carriers displayed lower levels of cortisol secretion in response to the TSST compared with Val/Val carriers; F(4.43, 496.238) = 2.57, p = 0.032. This is the first study to evaluate the role of the BDNF polymorphism in stress physiology among older adults. Future studies are needed to evaluate the lifespan interconnections between BDNF and stress physiology.

Peripheral biomarkers have shown significant value in predicting brain health and may serve as a useful proxy measurement in the assessment of evidence-based lifestyle behavior modification programs, including physical activity and nutrition programs, that aim to maintain cognitive function in late life. The aim of this systematic review was to elucidate which peripheral biomarkers are robustly associated with cognitive function among relatively healthy non-demented older adults. Following the standards for systematic reviews (PICO, PRIMSA), and employing MEDLINE and Scopus search engines, 222 articles were included in the review. Based on the review of biomarker proxies of cognitive health, it is recommended that a comprehensive biomarker panel, or biomarker signature, be developed as a clinical end point for behavior modification trials aimed at enhancing cognitive function in late life. The biomarker signature should take a multisystemic approach, including lipid, immune/inflammatory, and metabolic biomarkers in the biological signature index of cognitive health.

Clinician-led memory interventions have been shown to increase knowledge, reduce anxiety, promote memory-strategy use, and increase brain-healthy lifestyle behaviours in older adults with normal age-related memory changes. A self-guided, e-learning version of the Baycrest Memory and Aging Program® was recently developed to increase accessibility to memory interventions. The objectives of the current study were to assess program feasibility (retention rate), acceptability (satisfaction), and participant-reported impact (memory concerns, behaviour change, goal attainment). As part of a larger study, participants were 139 healthy older adults (mean age: 73±7, 73% female). Ninety-two individuals completed the program (retention rate=66%). Anonymous feedback data indicated a high level of satisfaction with the program overall (98%), the pace and clarity of the learning modules (100%), and the organization and navigation of the interface (92%). Suggested improvements included offering more interaction with others and addressing minor platform glitches. There was a decrease in the level of concern about memory change, with 64% expressing concern at a level consistent with the Jessen et al. (2014) criteria for Subjective Cognitive Decline at baseline, and 23% expressing the same at post-test. The majority of participants reported increases in using memory-strategies (63-97%) and lifestyle-promoting behaviours (40-72%). All participants reported moderate to high satisfaction with personal goal attainment. Results support feasibility, acceptability, and impact of a self-guided e-learning adaptation of memory intervention. E-learning tools may be a promising avenue to deliver accessible brain health promotion in later life, especially in the context of the shift to virtual care during and beyond COVID-19.

Research examining the effects of group-based mindfulness interventions on executive functioning have yielded inconsistent findings, with some reports of enhanced performance and other reports of null findings. Inconsistencies in the literature may be due to methodological differences across studies, including the type of control group employed and sample characteristics (e.g., clinical vs. non-clinical samples). The current systematic review and meta-analysis examined the effect of group-based mindfulness programs on executive functioning in persons 18+ years of age. Following the standards for systematic review, a total of 29 studies were included in the meta-analysis, of which 21 comparisons contributed to the analysis of inhibition; nine to working memory; nine to attention shifting; and four to the analysis of verbal fluency. After removing outliers, random effects models suggested a small but significant synthesized effect of group-mindfulness training on overall executive functioning (95% CI = 0.256, 0.725). Examination of executive subdomains after removing outliers suggested a small, statistically significant effect for inhibition (95% CI = 0.055, 0.387), working memory (95% CI = 0.010, 0.437), and verbal fluency (95% CI = 0.071, 1.931). No significant pooled effects were found for attention shifting. A priori subgroup analysis by randomization, type of control group, and sample cohort revealed inconsistent results. Overall, the current review suggests that the effect of group-based mindfulness training on executive functioning is not robust.

Background Consumption of a prudent dietary pattern rich in healthy nutrients is associated with enhanced cognitive performance in older adulthood, while a Western dietary pattern low in healthy nutrients is associated with poor age-related cognitive function. Sex differences exist in dietary intake among older adults; however, there is a paucity of research examining the relationship between sex-specific dietary patterns and cognitive function in later life. Methods The current study aimed to investigate sex differences in the relationship between sex-specific dietary pattern adherence and global cognitive function at baseline and over a 3-year follow-up in 1268 community-dwelling older adults (Mage = 74 years, n = 664 women, n = 612 men) from the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge). A 78-item Food Frequency Questionnaire was used to estimate dietary intake over the previous year. Sex-specific dietary pattern scores were derived using principal component analysis. Global cognition was assessed using the Modified Mini-Mental State Examination (3MS). Results Adjusted linear mixed effects models indicated that a healthy, prudent dietary pattern was not associated with baseline cognitive performance in men or women. No relationship was found between Western dietary pattern adherence and baseline cognitive function in women. Among men, adherence to an unhealthy, Western dietary pattern was associated with poorer baseline cognitive function (β = − 0.652, p = 0.02, 95% CI [− 1.22, − 0.65]). No association was found between prudent or Western dietary patterns and cognitive change over time in men or women. Conclusions These findings highlight the importance of conducting sex-based analyses in aging research and suggest that the relationship between dietary pattern adherence and cognitive function in late life may be sex-dependent.

Age-related memory changes pose considerable concerns for aging adults, and can adversely affect their daily living and cause worry even when changes experienced are not clinically significant. The Memory and Aging Program® is a validated psychoeducation and memory strategy-training program that teaches the public about memory changes during aging and trains them to use evidence-based strategies to support brain health. The program has been offered in-person for over 20 years, and a self-guided eLearning version was recently developed to improve program accessibility. This study evaluated the self-reported impacts of memory changes in older adults who completed this eLearning against a control group. We randomized 202 older adults, without neurological or psychiatric diagnoses (71.6 years; 69 % female; 15.6 years of education), into the eLearning program or a control group that received no intervention. All participants reported their perceived impact of memory changes using the Memory Impact Questionnaire at pre-, post-, and 6-8 weeks follow-up. A significant reduction in negative impact of memory changes on daily living and a significant improvement in positive coping with memory changes relative to controls was observed at post-test (13.4 versus 2.5 points reduction and 7.4 versus 0.1 point improvement, respectively, both p < 0.05), but these did not persist at follow-up. The adoption of digital tools has hastened across all ages. Our study showed that self-guided digital tools, such as the eLearning Memory and Aging Program®, may be a promising avenue to help aging individuals reduce the impact of memory changes on daily living.

Stress exposure over the lifespan is robustly associated with accelerated cognitive decline in later life. Brain-derived neurotrophic factor (BDNF) is shown to regulate activity of the hypothalamic-pituitary-adrenal axis. The objective of this study was to evaluate the association betweenthe BDNF polymorphism and indices of stress among adults aged 50+. Community-dwelling middle-aged and older adults provided a blood sample for BDNF genotyping. Participants also sampled their saliva 5 times/day for 3 consecutive days for the measurement of diurnal cortisol and underwent the Trier Social Stress Test (TSST) for the measurement of stress reactivity. Among 121 adults aged 50-67 years (78% female; 89% Caucasian), 74 participants were Val/Val carriers and 47 carried 1 copy of the Met allele. Repeated-measures analyses did not reveal an association between BDNF genotype and diurnal salivary cortisol (p = 0.63); however, analyses revealed that Met+ carriers displayed lower levels of cortisol secretion in response to the TSST compared with Val/Val carriers; F(4.43, 496.238) = 2.57, p = 0.032. This is the first study to evaluate the role of the BDNF polymorphism in stress physiology among older adults. Future studies are needed to evaluate the lifespan interconnections between BDNF and stress physiology.

Peripheral biomarkers have shown significant value in predicting brain health and may serve as a useful proxy measurement in the assessment of evidence-based lifestyle behavior modification programs, including physical activity and nutrition programs, that aim to maintain cognitive function in late life. The aim of this systematic review was to elucidate which peripheral biomarkers are robustly associated with cognitive function among relatively healthy non-demented older adults. Following the standards for systematic reviews (PICO, PRIMSA), and employing MEDLINE and Scopus search engines, 222 articles were included in the review. Based on the review of biomarker proxies of cognitive health, it is recommended that a comprehensive biomarker panel, or biomarker signature, be developed as a clinical end point for behavior modification trials aimed at enhancing cognitive function in late life. The biomarker signature should take a multisystemic approach, including lipid, immune/inflammatory, and metabolic biomarkers in the biological signature index of cognitive health.

Due to financial and mobility barriers, a majority of older adults living in collective dwellings are no longer able to engage in tourism, a leisure activity that contributes to quality of life and wellbeing. Immersive Virtual Reality (VR) may serve as a programmatic tool to facilitate tourism. This pilot study examined the effects of VR tourism exposure on indices of psychosocial wellbeing among older adults living in residential care. Using a mixed-methods study design, 18 older adults were exposed to VR tourism three times a week, over six weeks. Participants reported decreased anxiety and fatigue immediately following exposure, and increased social engagement and quality of life following six weeks of VR tourism. Qualitative data offered additional insight on the process by which VR tourism may enhance wellbeing. Findings suggest that immersive VR tourism may be a viable program for older adults in residential care.

Previous research suggests that high allostatic load (AL), a biological indicator of physiological dysregulation due to chronic stress, is associated with poor cognitive functioning. To date, no studies have systematically reviewed the literature to evaluate the strength and consistency of this relationship. The objective of this study was to conduct a systematic and meta-analytic review of studies that have investigated the association between AL and performance on standardized cognitive tests among adults aged 18 years and older. A total of 18 studies were retained for review. Meta-analyses revealed a significant cross-sectional association between higher AL and poor global cognition (r = -0.08, p 0.001) and executive function (r = -0.07, p = 0.02), but not memory (r = -0.07, p = 0.10). Due to variation in statistical methods used, longitudinal meta-analyses were not performed. Qualitative review of the literature suggests that AL algorithm, physiological systems and individual biomarkers included in the AL index, and sample age may be key moderators of the AL-cognition relationship. Although the magnitude of reported associations is small, findings support AL as a robust indicator of cognitive function among adults. Study limitations and future directions are discussed.

Allostatic load (AL), an index of multisystem physiological dysregulation due to chronic stress, has been identified as a predictor of poor health outcomes in late life. Research suggests that perceived social support (PSS) improves health outcomes by buffering the negative effects of stress on wellbeing and increasing health promoting behaviours including consumption of a healthy prudent diet (i.e., fruits, vegetables, lean meats, nuts, and seeds). Research to date has independently demonstrated that higher PSS and prudent diet intake have an effect on AL. A paucity of research, however, has examined how dietary consumption and PSS interact to effect AL in older adults. The objective of this study was to examine the interaction between PSS and prudent diet pattern on AL in 164 non-demented, community-dwelling older adults (Mage= 68.5(.52), 64% female). PSS and diet intake were measured using the Perceived Social Support Scale and the EPIC-Norfolk Food Frequency Questionnaire, respectively. AL was composed of 16 biomarkers stemming from neuroendocrine, metabolic, inflammatory, and cardiovascular systems, stratified by sex. Controlling for age and usual daily energy intake, higher prudent diet consumption (B=-2.04, p=.001), but not PSS, was associated with lower AL. Moderation analysis revealed that higher prudent diet intake was associated with lower AL only for those with low PSS (B=-.83, p=.0006) and mean level of PSS (B=-.43, p=.02). These findings suggest that chronic biological stress may be mitigated by consuming a healthy diet specifically for older adults with lower social support and may further inform intervention strategies to promote healthy aging.

Aim: In this study, we examined whether Chinese and White women with and without a history of breast cancer exhibit differences in physiological and psychological stress profiles. Methods: Diurnal and reactive salivary cortisol profiles and psychological stress patterns of 41 breast cancer survivors and 58 healthy women were assessed. Results: Breast cancer survivors displayed a blunted acute cortisol response but there was no main effect of ethnocultural membership. Subjective appraisals of stress during the acute stressor revealed a significant interaction between ethnocultural group, health status and time (p = 0.032). Conclusion: Our results support the existing literature though suggest group differences in the appraisal of stress; thus, underscoring the importance of cultural sensitivity and awareness among clinicians and existing programs.

Stress exposure over the lifespan is robustly associated with accelerated cognitive decline in late life. Researchers continue to investigate factors that determine individual differences in stress physiology. Brain derived neurotrophic factor is found to associate with cognitive trajectory in late life, and the Met allele of the functional Val66Met BDNF gene has been found to associate with poorer episodic memory and executive functioning in late life. The objective of this study was to evaluate the association between BDNF polymorphism and indices of stress among adults aged 50+. Community dwelling middle aged and older adults provided a blood sample for BDNF genotyping. Participants also sampled their saliva five times a day over three consecutive days for measurement of diurnal cortisol and underwent the Trier Social Stress Test (TSST) for measurement of stress reactivity. Among 120 adults aged 50–67 (83% female, 89% Caucasian), 73 participants were Val/Val carriers and 47 carried one copy of the Met allele (45 Val/Met, 2 Met/Met carriers). Val/Val and Met carriers did not differ on any demographic factors. Repeated measures analyses did not reveal an association between BDNF genotype and diurnal salivary cortisol (p=.63); however, analyses revealed that Met carriers displayed a blunted cortisol response to the TSST compared with Val/Val carriers, F(9, 936)=2.09, p=.03. This is the first study to evaluate the role of BDNF polymorphism in stress physiology among middle-aged and older adults. Future studies are needed to evaluate lifespan interconnections between BDNF, stress physiology and cognitive function.