30 results on '"Daniele Segagni"'
Search Results
2. From data to the decision: A software architecture to integrate predictive modelling in clinical settings.
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Antonio Martinez-Millana, Carlos Fernández-Llatas, Lucia Sacchi, Daniele Segagni, Sergio Guillén, Riccardo Bellazzi, and Vicente Traver 0001
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- 2015
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3. Improving risk-stratification of Diabetes complications using temporal data mining.
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Lucia Sacchi, Arianna Dagliati, Daniele Segagni, Paola Leporati, Luca Chiovato, and Riccardo Bellazzi
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- 2015
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4. Improving Clinical Decisions on T2DM Patients Integrating Clinical, Administrative and Environmental Data.
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Daniele Segagni, Lucia Sacchi, Arianna Dagliati, Valentina Tibollo, Paola Leporati, Pasquale De Cata, Luca Chiovato, and Riccardo Bellazzi
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- 2015
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5. A data gathering framework to collect Type 2 diabetes patients data.
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Arianna Dagliati, Lucia Sacchi, Mauro Bucalo, Daniele Segagni, Konstantia Zarkogianni, Antonio Martinez-Millana, Jorge Cancela, Francesco Sambo, Giuseppe Fico, Maria Teresa Meneu Barreira, Carlo Cerra, Konstantina S. Nikita, Claudio Cobelli, Luca Chiovato, María Teresa Arredondo, and Riccardo Bellazzi
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- 2014
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6. BigQ: a NoSQL based framework to handle genomic variants in i2b2.
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Matteo Gabetta, Ivan Limongelli, Ettore Rizzo, Alberto Riva, Daniele Segagni, and Riccardo Bellazzi
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- 2015
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7. ONCO-i2b2: Improve Patients Selection through Case-Based Information Retrieval Techniques.
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Daniele Segagni, Matteo Gabetta, Valentina Tibollo, Alberto Zambelli, Silvia G. Priori, and Riccardo Bellazzi
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- 2012
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8. The ONCO-I2b2 Project: Integrating Biobank Information and Clinical Data to Support Translational Research in Oncology.
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Daniele Segagni, Valentina Tibollo, Arianna Dagliati, Leonardo Perinati, Alberto Zambelli, Silvia G. Priori, and Riccardo Bellazzi
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- 2011
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9. A Dynamic Query System for Supporting Phenotype Mining in Genetic Studies.
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Angelo Nuzzo, Daniele Segagni, Giuseppe Milani, Carla Rognoni, and Riccardo Bellazzi
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- 2007
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10. An Integrated IT System for Phenotypic and Genotypic Data Mining and Management.
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Angelo Nuzzo, Daniele Segagni, Giuseppe Milani, Cinzia Sala, and Cristiana Larizza
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- 2007
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11. R Engine Cell: integrating R into the i2b2 software infrastructure.
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Daniele Segagni, Fulvia Ferrazzi, Cristiana Larizza, Valentina Tibollo, Carlo Napolitano, Silvia G. Priori, and Riccardo Bellazzi
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- 2011
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12. Mining Careflow Patterns in data warehouses of breast cancer patients.
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Lucia Sacchi, Daniele Segagni, Arianna Dagliati, Alberto Zambelli, and Riccardo Bellazzi
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- 2013
13. A dashboard-based system for supporting diabetes care
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Maria Teresa Arredondo, Antonio Martinez-Millana, Pasquale De Cata, Jorge Posada, Marsida Teliti, Giulia Cogni, Vicente Traver, Lucia Sacchi, Luca Chiovato, Manuel Ottaviano, Riccardo Bellazzi, Valentina Tibollo, Arianna Dagliati, Daniele Segagni, and Giuseppe Fico
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Decision support system ,020205 medical informatics ,Dashboard (business) ,Health Informatics ,02 engineering and technology ,Research and Applications ,Clinical decision support system ,TECNOLOGIA ELECTRONICA ,User-Computer Interface ,03 medical and health sciences ,0302 clinical medicine ,Computer Systems ,Data Warehousing ,Political science ,0202 electrical engineering, electronic engineering, information engineering ,Electronic Health Records ,Humans ,media_common.cataloged_instance ,030212 general & internal medicine ,European union ,media_common ,Medical education ,Data display ,Clinical decision support systems ,Type 2 diabetes ,Decision Support Systems, Clinical ,3. Good health ,Diabetes Mellitus, Type 2 ,Work (electrical) ,Data Display ,Data integration ,Temporal data analytics ,Software - Abstract
[EN] Objective To describe the development, as part of the European Union MOSAIC (Models and Simulation Techniques for Discovering Diabetes Influence Factors) project, of a dashboard-based system for the management of type 2 diabetes and assess its impact on clinical practice. Methods The MOSAIC dashboard system is based on predictive modeling, longitudinal data analytics, and the reuse and integration of data from hospitals and public health repositories. Data are merged into an i2b2 data warehouse, which feeds a set of advanced temporal analytic models, including temporal abstractions, care-flow mining, drug exposure pattern detection, and risk-prediction models for type 2 diabetes complications. The dashboard has 2 components, designed for (1) clinical decision support during follow-up consultations and (2) outcome assessment on populations of interest. To assess the impact of the clinical decision support component, a pre-post study was conducted considering visit duration, number of screening examinations, and lifestyle interventions. A pilot sample of 700 Italian patients was investigated. Judgments on the outcome assessment component were obtained via focus groups with clinicians and health care managers. Results The use of the decision support component in clinical activities produced a reduction in visit duration (P¿¿¿.01) and an increase in the number of screening exams for complications (P¿, This work was supported by the European Union in the Seventh Framework Programme, grant number 600914.
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- 2018
14. Decision-making for tracheostomy in amyotrophic lateral sclerosis (ALS): a retrospective study
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Daniele Segagni, Annalisa Carlucci, Annia Schreiber, Sara Surbone, and Piero Ceriana
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Male ,medicine.medical_specialty ,Clinical Decision-Making ,Decision Making ,Comorbidity ,Risk Assessment ,Utilization review ,03 medical and health sciences ,Tracheostomy ,0302 clinical medicine ,Prevalence ,medicine ,Humans ,Acute respiratory failure ,Amyotrophic lateral sclerosis ,Intensive care medicine ,decision-making ,planned ,tracheostomy ,unplanned ,Retrospective Studies ,business.industry ,Amyotrophic Lateral Sclerosis ,Patient Preference ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Italy ,030228 respiratory system ,Neurology ,Respiratory failure ,Utilization Review ,Emergency medicine ,Female ,Observational study ,Neurology (clinical) ,Respiratory Insufficiency ,Risk assessment ,business ,030217 neurology & neurosurgery - Abstract
ALS patients should discuss the issue of tracheostomy before the onset of terminal respiratory failure. While the process of shared decision-making is desirable, there are few data on the practical application of this real-life situation.To determine how a decision-making process is actually carried out, we analysed the episodes of acute respiratory failure preceding tracheostomy.We studied the charts of a group of ALS patients after tracheostomy. An interview focusing on the existence of anticipated directives was carried out. Tracheostomies were classified as planned or unplanned according to the presence of a decision plan.A total of 209 ALS patients were cared for during a three-year period. Of these patients, 34 (16%) were tracheotomised. In 38% of cases, tracheostomy was planned, 41% were unplanned, and 21% remained undiagnosed.A minority of ALS patients make a voluntary decision for tracheostomy before the procedure is conducted. The advising process of care still presents limits that have been thus far poorly addressed. In the future, we will need to develop guidelines for the timing and content of the shared-decision making process.
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- 2017
15. An ICT infrastructure to integrate clinical and molecular data in oncology research.
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Daniele Segagni, Valentina Tibollo, Arianna Dagliati, Alberto Zambelli, Silvia G. Priori, and Riccardo Bellazzi
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- 2012
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16. From data to the decision: A software architecture to integrate predictive modelling in clinical settings
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Vicente Traver, Lucia Sacchi, Sergio Guillen, Riccardo Bellazzi, Antonio Martinez-Millana, Carlos Fernandez-Llatas, and Daniele Segagni
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Computer science ,business.industry ,Clinical settings ,Data structure ,Data science ,Diabetes Mellitus, Type 2 ,Component (UML) ,Architecture ,Humans ,Data architecture ,Software architecture ,business ,Predictive modelling ,Mathematics ,Software ,Graphical user interface - Abstract
The application of statistics and mathematics over large amounts of data is providing healthcare systems with new tools for screening and managing multiple diseases. Nonetheless, these tools have many technical and clinical limitations as they are based on datasets with concrete characteristics. This proposition paper describes a novel architecture focused on providing a validation framework for discrimination and prediction models in the screening of Type 2 diabetes. For that, the architecture has been designed to gather different data sources under a common data structure and, furthermore, to be controlled by a centralized component ( Orchestrator) in charge of directing the interaction flows among data sources, models and graphical user interfaces. This innovative approach aims to overcome the data-dependency of the models by providing a validation framework for the models as they are used within clinical settings.
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- 2016
17. Improving risk-stratification of Diabetes complications using temporal data mining
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Daniele Segagni, Riccardo Bellazzi, Arianna Dagliati, Luca Chiovato, Lucia Sacchi, and Paola Leporati
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Drug Utilization ,education.field_of_study ,Decision support system ,Exploit ,business.industry ,Population ,Pharmacy ,Data science ,Health informatics ,Risk Assessment ,Purchasing ,Diabetes Complications ,Diabetes Mellitus, Type 2 ,Risk Factors ,Pharmaceutical Services ,Medicine ,Data Mining ,Humans ,Relevance (information retrieval) ,business ,Risk assessment ,education - Abstract
To understand which factor trigger worsened disease control is a crucial step in Type 2 Diabetes (T2D) patient management. The MOSAIC project, funded by the European Commission under the FP7 program, has been designed to integrate heterogeneous data sources and provide decision support in chronic T2D management through patients' continuous stratification. In this work we show how temporal data mining can be fruitfully exploited to improve risk stratification. In particular, we exploit administrative data on drug purchases to divide patients in meaningful groups. The detection of drug consumption patterns allows stratifying the population on the basis of subjects' purchasing attitude. Merging these findings with clinical values indicates the relevance of the applied methods while showing significant differences in the identified groups. This extensive approach emphasized the exploitation of administrative data to identify patterns able to explain clinical conditions.
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- 2016
18. BigQ: a NoSQL based framework to handle genomic variants in i2b2
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Daniele Segagni, Matteo Gabetta, Riccardo Bellazzi, Alberto Riva, Ettore Rizzo, and Ivan Limongelli
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i2b2 ,Databases, Factual ,Computer science ,Genomic data ,MEDLINE ,Information Storage and Retrieval ,Genomics ,NoSQL ,computer.software_genre ,Biochemistry ,Structural Biology ,Humans ,Molecular Biology ,Throughput (business) ,Applied Mathematics ,Variants ,High-Throughput Nucleotide Sequencing ,Precision medicine ,Data science ,Computer Science Applications ,Informatics ,NGS ,DNA microarray ,computer ,Software ,CouchDB - Abstract
Background Precision medicine requires the tight integration of clinical and molecular data. To this end, it is mandatory to define proper technological solutions able to manage the overwhelming amount of high throughput genomic data needed to test associations between genomic signatures and human phenotypes. The i2b2 Center (Informatics for Integrating Biology and the Bedside) has developed a widely internationally adopted framework to use existing clinical data for discovery research that can help the definition of precision medicine interventions when coupled with genetic data. i2b2 can be significantly advanced by designing efficient management solutions of Next Generation Sequencing data. Results We developed BigQ, an extension of the i2b2 framework, which integrates patient clinical phenotypes with genomic variant profiles generated by Next Generation Sequencing. A visual programming i2b2 plugin allows retrieving variants belonging to the patients in a cohort by applying filters on genomic variant annotations. We report an evaluation of the query performance of our system on more than 11 million variants, showing that the implemented solution scales linearly in terms of query time and disk space with the number of variants. Conclusions In this paper we describe a new i2b2 web service composed of an efficient and scalable document-based database that manages annotations of genomic variants and of a visual programming plug-in designed to dynamically perform queries on clinical and genetic data. The system therefore allows managing the fast growing volume of genomic variants and can be used to integrate heterogeneous genomic annotations. Electronic supplementary material The online version of this article (doi:10.1186/s12859-015-0861-0) contains supplementary material, which is available to authorized users.
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- 2015
19. Improving Clinical Decisions on T2DM Patients Integrating Clinical, Administrative and Environmental Data
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Daniele, Segagni, Lucia, Sacchi, Arianna, Dagliati, Valentina, Tibollo, Paola, Leporati, Pasqale, De Cata, Luca, Chiovato, and Riccardo, Bellazzi
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Systems Integration ,Diabetes Mellitus, Type 2 ,Italy ,Hospital Information Systems ,Electronic Health Records ,Medical Record Linkage ,Decision Support Systems, Clinical ,Environmental Monitoring - Abstract
This work describes an integrated informatics system developed to collect and display clinically relevant data that can inform physicians and researchers about Type 2 Diabetes Mellitus (T2DM) patient clinical pathways and therapy adherence. The software we developed takes data coming from the electronic medical record (EMR) of the IRCCS Fondazione Maugeri (FSM) hospital of Pavia, Italy, and combines the data with administrative, pharmacy drugs (purchased from the local healthcare agency (ASL) of the Pavia area), and open environmental data of the same region. By using different use cases, we explain the importance of gathering and displaying the data types through a single informatics tool: the use of the tool as a calculator of risk factors and indicators to improve current detection of T2DM, a generator of clinical pathways and patients' behaviors from the point of view of the hospital care management, and a decision support tool for follow-up visits. The results of the performed data analysis report how the use of the dashboard displays meaningful clinical decisions in treating complex chronic diseases and might improve health outcomes.
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- 2015
20. Big Data Technologies: New Opportunities for Diabetes Management
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Riccardo Bellazzi, Daniele Segagni, Lucia Sacchi, and Arianna Dagliati
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Decision support system ,Knowledge management ,Databases, Factual ,Endocrinology, Diabetes and Metabolism ,Big data ,Biomedical Engineering ,Bioengineering ,computer.software_genre ,Diabetes management ,Health care ,Internal Medicine ,Diabetes Mellitus ,Medicine ,Humans ,Disease management (health) ,Review Articles ,Chronic care ,business.industry ,Information technology ,Disease Management ,Decision Support Systems, Clinical ,Data science ,business ,computer ,Delivery of Health Care ,Data integration - Abstract
The so-called big data revolution provides substantial opportunities to diabetes management. At least 3 important directions are currently of great interest. First, the integration of different sources of information, from primary and secondary care to administrative information, may allow depicting a novel view of patient’s care processes and of single patient’s behaviors, taking into account the multifaceted nature of chronic care. Second, the availability of novel diabetes technologies, able to gather large amounts of real-time data, requires the implementation of distributed platforms for data analysis and decision support. Finally, the inclusion of geographical and environmental information into such complex IT systems may further increase the capability of interpreting the data gathered and extract new knowledge from them. This article reviews the main concepts and definitions related to big data, it presents some efforts in health care, and discusses the potential role of big data in diabetes care. Finally, as an example, it describes the research efforts carried on in the MOSAIC project, funded by the European Commission.
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- 2015
21. User requirements for incorporating diabetes modeling techniques in disease management tools
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Maria Teresa Arredondo, Vicente Traver, Antonio Martinez Millana, Alejandra Guillen, Daniele Segagni, Claudio Cobelli, Andrea Facchinetti, Carlos Fernandez-Llatas, Arianna Dagliati, Francesco Sambo, Lucia Sacchi, Giuseppe Fico, Jose Verdu, Riccardo Bellazzi, and Jorge Cancela
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Engineering ,Knowledge management ,endocrine system diseases ,business.industry ,Biomedical Engineering ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Health Technology Assessment ,Bioengineering ,medicine.disease ,User requirements document ,User Requirements ,Risk analysis (engineering) ,Type 2 Diabetes modeling ,Diabetes mellitus ,medicine ,Identification (biology) ,Disease management (health) ,business - Abstract
Type 2 Diabetes Mellitus (T2DM) is the most common form of diabetes. Early identification of people at risk of developing T2DM is extremely important, but the effectiveness of existing model is not clear as it is not clear the relative importance of the needs that such systems should satisfy.
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- 2015
22. A data gathering framework to collect Type 2 diabetes patients data
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Konstantia Zarkogianni, Maria Teresa Arredondo, Claudio Cobelli, Luca Chiovato, Mauro Bucalo, Lucia Sacchi, Carlo Cerra, Daniele Segagni, Jorge Cancela, Konstantina S. Nikita, Giuseppe Fico, Francesco Sambo, Antonio Martinez Millana, Arianna Dagliati, Riccardo Bellazzi, and Maria Teresa Meneu Barreira
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i2b2 ,History ,Exploit ,Data warehouses ,Computer science ,data acquisition ,public domain software ,Shared Health Research Information Network open source software tools ,multivariate models ,relevant clinical pathways ,Environmental data ,diseases ,MOSAIC activities ,data gathering framework ,Databases ,medical information systems ,Health care ,FP7 framework ,Ontologies ,In patient ,T2D ,SHRINE ,Temporal data mining ,Type 2 diabetes patient data ,medical centers ,Data collection ,business.industry ,Temporal Data Mining model development ,sharable data model ,Diabetes ,Data models ,Informatics for Integrating Biology and the Bedside ,bioinformatics ,data mining ,EU project MOSAIC ,Data science ,health care ,European hospitals ,Hospitals ,clinical data ,common data model ,environmental data ,integrated research setting ,local health care agency ,patient histories ,Informatics ,business ,Research setting - Abstract
In this work, we present a framework implemented within the EU project MOSAIC, funded under the FP7 framework, to gather Type 2 Diabetes (T2D) patients' data coming from three European hospitals and a local health care agency. A subset of the MOSAIC activities is centered on the development of Temporal Data Mining models to identify relevant clinical pathways in patients' histories and will in particular benefit from the data coming from the medical centers involved in the project. To best exploit this repository, the need for creating a common and sharable data model becomes immediately apparent. This model is the main subject of this paper. The proposed approach relies on the Informatics for Integrating Biology and the Bedside (i2b2) and the Shared Health Research Information Network (SHRINE) open source software tools. It provides an integrated research setting to merge clinical and environmental data that will enable obtaining a broader vision of individual patients' histories, which will be then mined with multivariate models to identify relevant clinical pathways.
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- 2014
23. Clinical and research data integration: the i2b2-FSM experience
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Daniele, Segagni, Valentina, Tibollo, Arianna, Dagliati, Alberto, Malovini, Alberto, Zambelli, Carlo, Napolitano, Silvia G, Priori, and Riccardo, Bellazzi
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In order to support and improve the efficiency of clinical research in specific health area, the University of Pavia and the IRCCS Fondazione Salvatore Maugeri of Pavia (FSM) are developing and implementing an i2b2 based platform, designed to collect data coming from hospital clinical practice and scientific research. The work made in FSM is committed to support an affordable, less intrusive and more personalized care, increasing the quality of clinical practice as well as improving the scientific results. Such a aim depends on the application of information and communication technologies and the use of data. An integrated data warehouse has been implemented to support clinicians and researchers in two medical fields with a great impact on the population: oncology and cardiology. Furthermore the data warehouse approach has been tested with administrative information, allowing a financial view of clinical data.
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- 2013
24. CARDIO-i2b2: integrating arrhythmogenic disease data in i2b2
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Daniele, Segagni, Valentina, Tibollo, Arianna, Dagliati, Carlo, Napolitano, Silvia, G Priori, and Riccardo, Bellazzi
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Systems Integration ,Electrocardiography ,User-Computer Interface ,Databases, Factual ,Italy ,Database Management Systems ,Information Storage and Retrieval ,Arrhythmias, Cardiac ,Medical Record Linkage - Abstract
The CARDIO-i2b2 project is an initiative to customize the i2b2 bioinformatics tool with the aim to integrate clinical and research data in order to support translational research in cardiology. In this work we describe the implementation and the customization of i2b2 to manage the data of arrhytmogenic disease patients collected at the Fondazione Salvatore Maugeri of Pavia in a joint project with the NYU Langone Medical Center (New York, USA). The i2b2 clinical research chart data warehouse is populated with the data obtained by the research database called TRIAD. The research infrastructure is extended by the development of new plug-ins for the i2b2 web client application able to properly select and export phenotypic data and to perform data analysis.
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- 2012
25. ONCO-i2b2: Improve Patients Selection through Case-Based Information Retrieval Techniques
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Matteo Gabetta, Alberto Zambelli, Daniele Segagni, Silvia G. Priori, Valentina Tibollo, and Riccardo Bellazzi
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Hospital information system ,Information retrieval ,Software ,business.industry ,Computer science ,Informatics ,Information technology ,Translational research ,Cancer Biobank ,Case-based reasoning ,business ,Research center - Abstract
The University of Pavia (Italy) and the IRCCS Fondazione Salvatore Maugeri hospital in Pavia have recently started an information technology initiative to support clinical research in oncology called ONCO-i2b2. This project aims at supporting translational research in oncology and exploits the software solutions implemented by the Informatics for Integrating Biology and the Bed-side (i2b2) research center. The ONCO-i2b2 software is designed to integrate the i2b2 infrastructure with the hospital information system, with the pathology unit and with a cancer biobank that manages both plasma and cancer tissue samples. Exploiting the medical concepts related to each patient, we have developed a novel data mining procedure that allows researchers to easily identify patients similar to those found with the i2b2 query tool, so as to increase the number of patients, compared to the patient set directly retrieved by the query. This allows physicians to obtain additional information that can support new insights in the study of tumors.
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- 2012
26. The ONCO-I2b2 project: integrating biobank information and clinical data to support translational research in oncology
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Daniele, Segagni, Valentina, Tibollo, Arianna, Dagliati, Leonardo, Perinati, Alberto, Zambelli, Silvia, Priori, and Riccardo, Bellazzi
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Medical Records Systems, Computerized ,Computers ,Information Storage and Retrieval ,Systems Integration ,Translational Research, Biomedical ,User-Computer Interface ,Italy ,Computer Systems ,Hospital Information Systems ,Humans ,Algorithms ,Software ,Biological Specimen Banks ,Natural Language Processing - Abstract
The University of Pavia and the IRCCS Fondazione Salvatore Maugeri of Pavia (FSM), has recently started an IT initiative to support clinical research in oncology, called ONCO-i2b2. ONCO-i2b2, funded by the Lombardia region, grounds on the software developed by the Informatics for Integrating Biology and the Bedside (i2b2) NIH project. Using i2b2 and new software modules purposely designed, data coming from multiple sources are integrated and jointly queried. The core of the integration process stands in retrieving and merging data from the biobank management software and from the FSM hospital information system. The integration process is based on a ontology of the problem domain and on open-source software integration modules. A Natural Language Processing module has been implemented, too. This module automatically extracts clinical information of oncology patients from unstructured medical records. The system currently manages more than two thousands patients and will be further implemented and improved in the next two years.
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- 2011
27. R engine cell: integrating R into the i2b2 software infrastructure
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Fulvia Ferrazzi, Cristiana Larizza, Valentina Tibollo, Daniele Segagni, Carlo Napolitano, Silvia G. Priori, and Riccardo Bellazzi
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Academic Medical Centers ,Biomedical Research ,Computer science ,business.industry ,Health Informatics ,Arrhythmias, Cardiac ,Kaplan-Meier Estimate ,Brief Communication ,Data science ,Set (abstract data type) ,Systems Integration ,User-Computer Interface ,Software ,Italy ,Computer Systems ,Statistical analyses ,Informatics ,Humans ,Registries ,User interface ,business ,Statistical software ,Information Systems - Abstract
Informatics for Integrating Biology and the Bedside (i2b2) is an initiative funded by the NIH that aims at building an informatics infrastructure to support biomedical research. The University of Pavia has recently integrated i2b2 infrastructure with a registry of inherited arrhythmogenic diseases. Within this project, the authors created a novel i2b2 cell, named R Engine Cell, which allows the communication between i2b2 and the R statistical software. As survival analyses are routinely performed by cardiology researchers, the authors have first concentrated on making Kaplan–Meier analyses available within the i2b2 web interface. To this aim, the authors developed a web-client plug-in to select the patient set on which to perform the analysis and to display the results in a graphical, intuitive way. R Engine Cell has been designed to easily support the integration of other R-based statistical analyses into i2b2.
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- 2011
28. A dynamic query system for supporting phenotype mining in genetic studies
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Angelo, Nuzzo, Daniele, Segagni, Giuseppe, Milani, Carla, Rognoni, and Riccardo, Bellazzi
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Genetics, Population ,Phenotype ,Databases as Topic ,Medical Records Systems, Computerized ,Computational Biology ,Humans ,Information Storage and Retrieval - Abstract
This paper describes an information technology infrastructure aimed at supporting translational bioinformatics studies that require joint management of phenotypic and genotypic data. In particular, we integrated an electronic medical record with an open-source environment for data mining to create a flexible and easy to use query system aimed at supporting the discovery of the most frequent complex traits. We propose a logical formalization to define the phenotypes of interest; this is translated into a graphical interface that allows the user to combine different conditions relative to the electronic medical record data (e.g., the presence of a particular pathology). The phenotypes are then stored in a multidimensional database. Then, the data mining system engine reads the filtered data from the database and executes dynamic queries for analyzing phenotypic data, presenting the results in a multidimensional format through a simple web interface. The system has been applied in a study on genetically isolated individuals, the Val Borbera project.
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- 2007
29. Onco-i2b2 Project: A Bioinformatics Tool Integrating –Omics and Clinical Data to Support Translational Research
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S. Manera, Alberto Zambelli, V. Fotia, Valentina Tibollo, Arianna Dagliati, Riccardo Bellazzi, Daniele Segagni, and Alberto Malovini
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Hospital information system ,SNOMED CT ,Exploit ,business.industry ,Translational research ,Hematology ,Biobank ,Data science ,Software ,Oncology ,Informatics ,Management system ,Medicine ,business - Abstract
The ONCO-i2b2 project, supported by the University of Pavia and the Fondazione Salvatore Maugeri (FSM), aims at supporting translational research in oncology and exploits the software solutions implemented by the Informatics for Integrating Biology and the Bedside (i2b2) research centre, an initiative funded by the NIH Roadmap National Centres for Biomedical Computing. The ONCO-i2b2 software is designed to integrate the i2b2 infrastructure with the FSM hospital information system and the Bruno Boerci Biobank, in order to provide well-characterized cancer specimens along with an accurate patients clinical data-base. The i2b2 infrastructure provides a web-based access to all the electronic medical records of cancer patients, and allow researchers analyzing the vast amount of biological and clinical information, relying on a user-friendly interface. Data coming from multiple sources are integrated and jointly queried. In 2011 at AIOM Meeting we reported the preliminary experience of the ONCO-i2b2 project, now we're able to present the up and running platform and the extended data set. Currently, more than 4400 specimens are stored and more than 600 of breast cancer patients give the consent for the use of specimens in the context of clinical research, in addition, more than 5000 histological reports are stored in order to integrate clinical data. Within the ONCO-i2b2 project is possible to query and merge data regarding: • Anonymous patient personal data; • Diagnosis and therapy ICD9-CM subset from the hospital information system; • Histological data (tumour SNOMED and TNM codes) and receptor profile testing (Her2, Ki67) from anatomic pathology database; • Specimen molecular characteristics (DNA, RNA, blood, plasma and cancer tissues) from the Bruno Boerci biobank management system. The research infrastructure will be completed by the development of new set of components designed to enhance the ability of an i2b2 hive to utilize data generated by NGS technology, providing a mechanism to apply custom genomic annotations. The translational tool created at FSM is a concrete example regarding how the integration of different information from heterogeneous sources could bring scientific research closer to understand the nature of disease itself and to create novel diagnostics through handy interfaces. Disclosure All authors have declared no conflicts of interest.
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- 2012
30. An ICT infrastructure to integrate clinical and molecular data in oncology research
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Valentina Tibollo, Riccardo Bellazzi, Silvia G. Priori, Alberto Zambelli, Daniele Segagni, and Arianna Dagliati
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Oncology ,medicine.medical_specialty ,Databases, Factual ,Computer science ,Interface (computing) ,Information Storage and Retrieval ,Translational research ,Breast Neoplasms ,lcsh:Computer applications to medicine. Medical informatics ,Medical Oncology ,Biochemistry ,Translational Research, Biomedical ,Software ,Structural Biology ,Internal medicine ,medicine ,Humans ,lcsh:QH301-705.5 ,Molecular Biology ,Natural Language Processing ,business.industry ,Applied Mathematics ,Research ,Data science ,Data warehouse ,Computer Science Applications ,lcsh:Biology (General) ,Information and Communications Technology ,Informatics ,Hospital Information Systems ,lcsh:R858-859.7 ,business ,Research center - Abstract
Background The ONCO-i2b2 platform is a bioinformatics tool designed to integrate clinical and research data and support translational research in oncology. It is implemented by the University of Pavia and the IRCCS Fondazione Maugeri hospital (FSM), and grounded on the software developed by the Informatics for Integrating Biology and the Bedside (i2b2) research center. I2b2 has delivered an open source suite based on a data warehouse, which is efficiently interrogated to find sets of interesting patients through a query tool interface. Methods Onco-i2b2 integrates data coming from multiple sources and allows the users to jointly query them. I2b2 data are then stored in a data warehouse, where facts are hierarchically structured as ontologies. Onco-i2b2 gathers data from the FSM pathology unit (PU) database and from the hospital biobank and merges them with the clinical information from the hospital information system. Our main effort was to provide a robust integrated research environment, giving a particular emphasis to the integration process and facing different challenges, consecutively listed: biospecimen samples privacy and anonymization; synchronization of the biobank database with the i2b2 data warehouse through a series of Extract, Transform, Load (ETL) operations; development and integration of a Natural Language Processing (NLP) module, to retrieve coded information, such as SNOMED terms and malignant tumors (TNM) classifications, and clinical tests results from unstructured medical records. Furthermore, we have developed an internal SNOMED ontology rested on the NCBO BioPortal web services. Results Onco-i2b2 manages data of more than 6,500 patients with breast cancer diagnosis collected between 2001 and 2011 (over 390 of them have at least one biological sample in the cancer biobank), more than 47,000 visits and 96,000 observations over 960 medical concepts. Conclusions Onco-i2b2 is a concrete example of how integrated Information and Communication Technology architecture can be implemented to support translational research. The next steps of our project will involve the extension of its capabilities by implementing new plug-in devoted to bioinformatics data analysis as well as a temporal query module.
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