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This text intends to pursue the following aims: to state how teenagers see room for dreams in mathematics classes and how to make more room for dreams during these classes. It is qualitative research, whose theoretical framework is based on Ole Skovsmose, Paulo Freire and Emanuel Levinas; and the methodology is inspired by case study and oral history. Data production took place with adolescents from two schools: one located in Colombia and the other in Brazil. The data discussed here are based on two discussion groups. Throughout the text, it is addressed some theoretical concepts and presented some of the data, based on students’ discussions about possible room at mathematics classes for teenagers’ dreams. In the sequence, it is stated some reflections, criticizing mathematics classes based on exercise paradigm, and the relationships stablished during these classes, which do not allow an opening space for students’ dreams.

BackgroundMolecular epidemiology techniques allow us to track the HIV-1 transmission dynamics. Herein, we combined genetic, clinical and epidemiological data collected during routine clinical treatment to evaluate the dynamics and characteristics of transmission clusters of the most prevalent HIV-1 subtypes in the state of São Paulo, Brazil.MethodsThis was a cross-sectional study conducted with 2,518 persons living with HIV (PLWH) from 53 cities in São Paulo state between Jan 2004 to Feb 2015. The phylogenetic tree of protease/reverse transcriptase (PR/RT) regions was reconstructed by PhyML and ClusterPicker used to infer the transmission clusters based on Shimodaira–Hasegawa (SH) greater than 90% (phylogenetic support) and genetic distance less than 6%.ResultsOf a total of 2,518 sequences, 2,260 were pure subtypes at the PR/RT region, being B (88%), F1 (8.1%), and C (4%). About 21.2% were naïve with a transmitted drug resistance (TDR) rate of 11.8%. A total of 414 (18.3%) of the sequences clustered. These clusters were less evident in subtype B (17.7%) and F1 (15.1%) than in subtype C (40.2%). Clustered sequences were from PLWH at least 5 years younger than non-clustered among subtypes B (p

PURPOSEBreast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The Latin American Cancer Research Network was established to address these challenges and to promote collaborative clinical research. The Molecular Profiling of Breast Cancer Study (MPBCS) aimed to evaluate the clinical characteristics and treatment outcomes of LA participants with locally advanced breast cancer (LABC).PATIENTS AND METHODSThe MPBCS enrolled 1,449 participants from Argentina, Brazil, Chile, Mexico, and Uruguay. Through harmonized procedures and quality assurance measures, this study evaluated clinicopathologic characteristics, neoadjuvant chemotherapy response, and survival outcomes according to residual cancer burden (RCB) and the type of surgery.RESULTSOverall, 711 and 480 participants in the primary surgery and neoadjuvant arms, respectively, completed the 5-year follow-up period. Overall survival was independently associated with RCB (worse survival for RCBIII-adjusted hazard ratio, 8.19, P < .001, and RCBII [adjusted hazard ratio, 3.69, P < .008] compared with RCB0 [pathologic complete response or pCR]) and type of surgery (worse survival in mastectomy than in breast-conserving surgery [BCS], adjusted hazard ratio, 2.97, P = .001). The hormone receptor–negative-human epidermal growth factor receptor 2–positive group had the highest proportion of pCR (48.9%). The analysis of the ASCO Quality Oncology Practice Initiative breast module revealed high compliance with pathologic standards but lower adherence to treatment administration standards. Notably, compliance with trastuzumab administration varied widely among countries (33.3%-88.7%).CONCLUSIONIn LABC, we demonstrated the survival benefit of BCS and the prognostic effect of the response to available neoadjuvant treatments despite an important variability in access to key treatments. The MPBCS represents a significant step forward in understanding the real-world implementation of oncologic procedures in LA.

Abstract Objective: To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups. Methods: A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102). Results: Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE. Conclusion: It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE.

Objectives: We investigated the impact of school reopening on SARS-CoV-2 transmission in Italy, Germany, and Portugal in autumn 2022 when the Omicron variant was prevalent. Methods: A prospective international study was conducted using the case reproduction number (Rc) calculated with the time parametrization of Omicron. For Germany and Italy, staggered difference-in-differences analysis was employed to explore the causal relationship between school reopening and Rc changes, accounting for varying reopening dates. In Portugal, interrupted time series analysis was used due to simultaneous school reopenings. Multivariable models were adopted to adjust for confounders. Results: In Italy and Germany, post-reopening Rc estimates were significantly lower compared to those from regions/states that had not yet reopened at the same time points, both in the student population (overall average treatment effect for the treated subpopulation [O-ATT]: -0.80 [95% CI: -0.94;-0.66] for Italy; O-ATT-0.30 [95% CI: -0.36;-0.23] for Germany) and the adult population (O-ATT: -0.04 [95% CI: -0.07;-0.01] for Italy; O-ATT: -0.07 [95% CI: -0.11;-0.03] for Germany). In Portugal, there was a significant decreasing trend in Rc following school reopenings compared to the pre-reopening period (sustained effect: -0.03 [95% CI: -0.04; -0.03] in students; -0.02 [95% CI: -0.03; -0.02] in adults). Conclusions: We found no evidence of a causal relationship between school reopenings in autumn 2022 and Omicron SARS-CoV-2 transmission.

Introdução: A cirurgia de revascularização cardíaca é um procedimento que provoca muitas modificações na capacidade funcional e na composição corporal, levando a redução da qualidade de vida desses pacientes. Objetivo: Avaliar os efeitos do treinamento físico aquático na capacidade funcional e composição corporal de paciente revascularizado. Materiais e Métodos: Este artigo se caracterizou como um estudo de caso, desenvolvido no departamento de Educação Física da Universidade Ceuma, em São Luís-MA. Além disso, o estudo foi aprovado pelo Comitê de Ética em Pesquisa da Universidade Ceuma, sob o parecer de número 3.370.496. A amostra foi composta por um homem sedentário, 41 anos, eutrófico (IMC: 24,39), e que foi submetido a cirurgia de revascularização do miocárdio. A capacidade funcional foi avaliada através dos testes de sentar e levantar (5 vezes), teste de caminhada de 6’ (TC6) e Time Up And Go (TGU), enquanto a composição corporal foi avaliada através da Bioimpedância Tetrapolar da marca Sanny®. As sessões de treinamento aquático foram realizadas duas vezes por semana durante dois meses. Resultados: Após esse período foi possível observar aumento de 1,45kg de massa magra, redução da adiposidade absoluta e relativa (2,15kg/2,97%), diminuição do tempo nos testes de sentar e levantar (5 vezes), Time Up And Go e um acréscimo de 99,2m na distância percorrida no TC6. Conclusão: Diante do exposto, conclui-se que o protocolo de treinamento aquático promoveu hipertrofia, emagrecimento e melhora na capacidade funcional do sujeito avaliado.

BackgroundSerological surveys for SARS-CoV-2 were used early in the COVID-19 pandemic to assess epidemiological scenarios. In the municipality of Cascais (Portugal), serological testing combined with a comprehensive socio-demographic, clinical and behavioral questionnaire was offered to residents between May 2020 and beginning of 2021. In this study, we analyze the factors associated with adherence to this municipal initiative, as well as the sociodemographic profile and chronic diseases clinical correlates associated to seropositivity. We aim to contribute with relevant information for future pandemic preparedness efforts.MethodsThis was a cross-sectional study with non-probabilistic sampling. Citizens residing in Cascais Municipality went voluntarily to blood collection centers to participate in the serological survey. The proportion of participants, stratified by socio-demographic variables, was compared to the census proportions to identify the groups with lower levels of adherence to the survey. Univariate and multivariate logistic regression were used to identify socio-demographic, clinical and behavioral factors associated with seropositivity.ResultsFrom May 2020 to February 2021, 19,608 participants (9.2% of the residents of Cascais) were included in the study. Based on the comparison to census data, groups with lower adherence to this survey were men, the youngest and the oldest age groups, individuals with lower levels of education and unemployed/inactive. Significant predictors of a reactive (positive) serological test were younger age, being employed or a student, and living in larger households. Individuals with chronic diseases generally showed lower seroprevalence.ConclusionThe groups with low adherence to this voluntary study, as well as the socio-economic contexts identified as more at risk of viral transmission, may be targeted in future pandemic situations. We also found that the individuals with chronic diseases, perceiving higher risk of serious illness, adopted protective behaviors that limited infection rates, revealing that health education on preventive measures was effective for these patients.

Purpose The aim of this study was to characterize and compare the motor competence and physical fitness in dancers of different styles considering age, body mass index, and physical activity level (min/week). Methods Overall, 17 female dancers aged 13–31 years (18.00 ± 4.80) participated in this study. The sample was divided into 2 groups: (1) dancers who practised up to 3 styles ( n = 10); (2) dancers who practised 4 or more styles ( n = 7). The Fit School and Motor Competence Assessment test batteries were applied to analyse physical fitness and motor competence, respectively. All variables were tested for normal distribution by using the Shapiro-Wilk test. For continuous variables, the t -test was used and for nominal variables, the chi-square test was employed. For those that did not follow normal distribution, the Mann-Whitney U -test was applied. Results For either motor competence or physical fitness, the number of dance styles did not exert any influence. Furthermore, no significant differences were found for between-group comparisons. Conclusions The total group fell within the average reference values in all the physical fitness tests, with the exception of the 20-m multistage maximum shuttle run test. With regard to the number of dance styles practised, no differences between groups were observed for either motor competence or physical fitness.

Introdução: A obesidade é considerada como um dos principais problemas de saúde pública. Para a prevenção e tratamento desta condição, foi instituída no Brasil a Política Nacional de Promoção da Saúde, que atua juntamente com o Sistema Único de Saúde. Objetivo: Verificar as ações e estratégias relatadas nos últimos 10 anos no controle e prevenção da obesidade na Atenção Primária a Saúde no Brasil. Metodologia: Revisão sistemática seguindo o PRISMA, pesquisados na plataforma BVS. Foram considerados artigos publicados entre 2011 e 2021. Resultados: Foram encontrados 113 artigos a partir das palavras chaves, 97 foram triados após eliminação a partir do contexto, população e desenho dos estudos, destes, 16 artigos foram analisados, com desenho de Intervenção, tipo antes e depois e Intervenção quase experimental, com adultos, com média de follow up de 7 meses. A maior parte dos estudos atuaram em Educação Alimentar e Nutricional e utilizaram programas de intervenção nutricional. Utilizaram estratégia de grupo controle e intervenção ou realizaram análise pré e pós intervenção. Dos estudos que realizaram análise entre grupos, foi observada melhoria no grupo intervenção em relação a hábitos alimentares e redução de medidas antropométricas, mesmo identificado nos estudos que realizaram análise pré e pós intervenção. Conclusões: Diante da melhoria observada no perfil antropométrico, dietético, bioquímico e de nível de conhecimento dos participantes dos estudos revisados, é visto o grande impacto das intervenções em saúde na população assistida na atenção primária, em especial àquelas relacionadas à educação alimentar e nutricional.

Hormonal changes added to extrinsic exposure factors, including socio-environmental and lifestyle factors, affect the quality of life of climacteric women. Symptoms during the climacteric are variable, and most women are not aware that menopause affects the skin. Among the perceived changes, there is an increase in dryness, roughness, sagging, and atrophied skin. This article reviews the relationship between exposure and menopause, focusing on helping dermatologists to guide patients on preventive care and treatments to improve skin and quality of life in menopause.

Abstract High‐dose methylprednisolone plus rituximab (R‐HDMP) is a useful treatment in chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) patients unfit for chemo‐immunotherapy and has proven its utility on the treatment of CLL/SLL complicated by auto‐immune cytopenias. We performed a retrospective, single‐centre study, of CLL/SLL patients treated with R‐HDMP for 9 years. Thirty‐nine patients were included, median age at time of treatment was 77 years. Most patients had stage Rai III/IV and Binet C disease. Twenty‐eight patients had relapsed/refractory disease at time of treatment with a median of 1 previous line of therapy; 53.8% had prior exposure to fludarabine and 25% to rituximab. Grade 3–4 neutropenia and thrombocytopenia were recorded in 10.2% and 17.9% patients, respectively. While on treatment, 51.3% had documented infectious complications, but no other non‐haematological toxicities grades 3–4 were identified. Overall response rate was 64%. Median overall survival and progression‐free survival were 24 and 13 months, respectively. Twenty four patients relapsed and 16 received another line of treatment after R‐HDMP, with median time to next treatment of 13.5 months. Thirteen out of the 24 patients improved performance status and were subsequently considered fit for chemo‐immunotherapy. R‐HDMP is a valuable option for elderly and frail patients, with low risk of severe myelotoxicity and other severe adverse events. It was shown to work as a bridge to other lines of treatment, including chemo‐immunotherapy.

O objetivo deste estudo foi o de avaliar a eficácia da punção aspirativa por agulha fina (PAAF) da tireóide comparando-a com o diagnóstico histopatológico. Os autores avaliaram os resultados citológicos de 50 pacientes atendidos no período de dezembro de 1995 a julho de 1997, nos Departamentos de Citopatologia, Anatomia Patológica e Cirurgia da Santa Casa de Belo Horizonte, Minas Gerais. No mesmo período foram realizados 256 PAAF de tireóide, sendo que somente 50 pacientes foram à cirurgia e puderam ter os diagnósticos citológicos comparados aos histológicos. O grupo estudado consistiu em 40 mulheres e 10 homens, com idades variando entre 10 e 79 anos, sendo a maior incidência observada nas 4ª e 5ª décadas. Baseando-se na comparação dos diagnósticos, os autores obtiveram as taxas de sensibilidade (80%), especificidade (100%), valor preditivo positivo (100%), valor preditivo negativo (89,5%) e acurácia (92,6%). De acordo com estes resultados, pôde-se concluir que a PAAF é um método seguro, eficiente e confiável no diagnóstico dos nódulos tireoidianos.

Background: The increased demand for cosmetic facial treatments is a universal reality, and Brazil is the second country with the most procedures. Quality of life questionnaires can help assess results objectively and reveal data not yet explored in the scientific literature. Thus, the process of translation, adaptation, and validation of questionnaires is necessary for data universalization. Objective: To translate, adapt and validate a specific questionnaire to assess facial cosmetics procedures in Brazilian Portuguese. Methods: After choosing the Skin Rejuvenation Outcome Evaluation (SROE) questionnaire, the translation process started. A literal translation was performed, with the subsequent synthesis of the versions. Then, a team of experts conducted the reverse translation and final validation. The data obtained were statistically analyzed for validation. Results: The final version was called "Avaliação dos Resultados de Rejuvenescimento da Pele" (ARRP). The Cronbach’s resulted in values above 0.70, showing good internal consistency. The Intraclass Correlation Coefficient was 0.995 (p

Abstract Background: Vitiligo is a muco-cutaneous, autoimmune, localized, or disseminated disease, which manifests through hypochromic or achromic macules, with loss in quality of life. The prevalence of vitiligo in Brazil was determined to be 0.54%. There is no on-label medication for its treatment. To date, no Brazilian consensus on the treatment of vitiligo had been written. Objectives: The objective of this group of Brazilian dermatologists with experience in the treatment of this disease was to reach a consensus on the clinical and surgical treatment of vitiligo, based on articles with the best scientific evidence. Methods: Seven dermatologists were invited, and each was assigned two treatment modalities to review. Each treatment (topical, systemic, and phototherapy) was reviewed by three experts. Two experts reviewed the surgical treatment. Subsequently, the coordinator compiled the different versions and drafted a text about each type of treatment. The new version was returned to all experts, who expressed their opinions and made suggestions for clarity. The final text was written by the coordinator and sent to all participants to prepare the final consensus. Results/Conclusion: The experts defined the following as standard treatments of vitiligo: the use of topical corticosteroids and calcineurin inhibitors for localized and unstable cases; corticosteroid minipulse in progressive generalized vitiligo; narrowband UVB phototherapy for extensive forms of the disease. Surgical modalities should be indicated for segmental and stable generalized vitiligo. Topical and systemic anti-JAK drugs are being tested, with promising results.

Introducción: a raíz de la emergencia por la COVID-19, las medidas de distanciamiento social adoptadas para mitigar la tasa de infección pueden influenciar los hábitos alimentarios y otros factores de estilo de vida. El objetivo de este estudio fue evaluar la relación del distanciamiento social y los factores de estilo de vida en adultos del sureste brasilero durante la primera ola pandémica. Metodología: se trata de un estudio transversal con 1828 adultos de entre 18 y 83 años, de ambos sexos, realizado a través de un cuestionario en línea; se recolectaron y analizaron datos sociodemográficos, alimentarios, sanitarios y de estilo de vida, en función de si se guardó o no el distanciamiento social. Resultados: los resultados mostraron disminución del desayuno (12,5 %) y aumento del consumo de meriendas (24,5 % matutina y 12,5 % vespertina) y picoteos entre comidas (20,4 %), así como de la ingesta de verduras y leguminosas entre quienes estaban recluidos y de pescado y comida rápida entre los que no lo estaban; la mayoría de participantes reportó ganancia de peso a lo largo de este periodo. Las personas en confinamiento dormían más y su principal causa de ansiedad fueron las estadísticas de la enfermedad. Conclusión: los hallazgos sugieren la necesidad de implementar estrategias de promoción de la salud acordes a circunstancias como la actual.

Introdução: A fibromialgia é uma síndroma reumatológica crónica, de etiologia desconhecida, caracterizada pela distribuição generalizada de queixas álgicas e uma multiplicidade de sintomas. O seu tratamento continua a ser um importante desafio. Alguns fármacos antipsicóticos, como a quetiapina, têm sido estudados como terapêutica adjuvante. No entanto, existe ainda alguma controvérsia relativamente à sua eficácia e segurança. O objetivo deste trabalho foi avaliar o papel da quetiapina no controlo de sintomas em indivíduos com fibromialgia. Métodos: Foi realizada uma revisão bibliográfica com pesquisa de artigos em diferentes plataformas científicas utilizando os termos MeSH fibromyalgia e quetiapine. Foram incluídos estudos que cumpriam os critérios definidos pelo modelo PICOS: (P) adultos com diagnóstico de fibromialgia; (I) plano terapêutico com recurso a quetiapina; (C) placebo ou outro tipo de comparador; (O) alívio de sintomas e perfis de tolerabilidade e segurança; (S) revisões sistemáticas e ensaios clínicos aleatorizados controlados. Foi utilizada a escala Strength of Recommendation Taxonomy, da American Academy of Family Physicians, para avaliação dos níveis de evidência e atribuição de forças de recomendação. Resultados: Dos 66 artigos encontrados foram selecionados três ensaios clínicos aleatorizados controlados. Os resultados encontrados são heterogéneos e apesar de, na sua generalidade, parecerem mostrar vantagem no controlo dos principais sintomas dos doentes com a utilização da quetiapina não foi encontrada evidência robusta que comprove um benefício inequívoco. Os autores relataram boa tolerância e ausência de efeitos adversos severos com o seu uso. Conclusões: A evidência atual é de fraca qualidade, não livre de viés e de difícil generalização, apesar de aparentemente favorável no alívio parcial de alguns sintomas de doentes com fibromialgia (força de recomendação B). Este perfil positivo não é sustentado por significância estatística. É necessário realizar novos estudos, mais robustos, com estrutura e metodologia mais específicas, claras e consensuais, de forma a chegar a conclusões de qualidade.

Atrophic acne scars are persistent and undesirable sequelae that have a negative cosmetic and psychosocial impact on patients. This issue becomes more delicate when such scars are located in the presternal region due to the risk of hypertrophic scars appearing when performing these procedures in the area. The literature has long recognized the role of insulin in promoting protein and fat synthesis. Insulin properties as a growth factor to treat these sequelae seems logical and has proved cosmetically satisfying, with quality of life improvement.

Introdução: Com frequência, pacientes solicitam avaliação e tratamento para o rejuvenescimento das regiões perioral e periorbitária. Na maioria das vezes, é preciso usar uma combinação de procedimentos para que o resultado atenda às expectativas. Objetivo: Por meio de um estudo prospectivo, unicêntrico e comparativo, comparar o rejuvenescimento das regiões perioral e periorbital, após tratamento com peeling químico médio com fenol 88% com ou sem a aplicação prévia de toxina botulínica. Métodos: O peeling regional de fenol 88% foi utilizado em 16 pacientes; em oito delas houve aplicação de toxina botulínica duas semanas antes. A avaliação foi feita por meio de fotografias padronizadas e escalas de avaliação por médicos e pacientes. Resultados: A avaliação global por médicos e pacientes no 45º dia foi considerada excelente ou boa para todas as pacientes, com pequena vantagem para o tratamento combinado na região periorbital. Conclusão: A combinação desses dois procedimentos de custo relativamente baixo, muitas vezes negligenciado pelos dermatologistas, resultou na melhora significativa das alterações do envelhecimento dessas áreas.

A revolução digital nos serviços de saúde veio disponibilizar novas oportunidades para o desenvolvimento da qualidade da prestação de cuidados, investigação de novos tratamentos e uma melhor utilização dos recursos. A maioria da informação que presentemente é partilhada digitalmente, anteriormente era partilhada em papel, suscitando, assim, novos desafios e ameaças digitais ao nível da segurança e privacidade. Existiam cerca de 28 leis de proteção de dados diferentes baseados na EU Data Protection Directive de 1995, a qual foi desenhada há 20 anos atrás, antes da introdução generalizada da Internet e do crescimento das preocupações com a privacidade. Apesar dos avanços tecnológicos, a regulamentação existente permaneceu estagnada e cada vez mais inadequada para proteger os dados dos indivíduos ou das organizações. Dada esta necessidade foi desenvolvido e aprovado o Regulamento 2016/679, do Parlamento Europeu e do Conselho, de 27 de abril de 2016, relativo à proteção das pessoas singulares no que diz respeito ao tratamento de dados pessoais e à livre circulação desses dados. O Regulamento Geral sobre a Proteção de Dados veio introduzir alterações significativas ao enquadramento legal da proteção de dados pessoais dentro da União Europeia, estabelecendo regras relativas à proteção das pessoas singulares no que diz respeito ao tratamento de dados pessoais e à livre circulação desses dados. Estas alterações devem influenciar o modo de tratamento dos dados de saúde pelas entidades prestadoras de cuidados de saúde, quer no âmbito da prestação de cuidados de saúde quer para efeitos de investigação.

Os espaços não formais se mostram como grandes potencialidades para ampliação do ensino e aprendizagem em Ciências da Natureza. Através da pergunta geradora: como as pesquisas e produções acadêmicas sobre identificação e contribuições de espaços não formais para o ensino e aprendizagem em Ciências da Natureza vêm sendo abordadas? o presente artigo tem como objetivo apresentar um panorama do que se tem estudado, a partir da pesquisa bibliográfica de publicações científicas (anais de eventos, periódico nacional, teses e dissertações) publicadas entre 2014 a 2019 que versam unicamente com a temática sobre a identificação e análise dos potenciais dos espaços não formais. Os trabalhos apontados possibilitaram produzir resultados relativos a novos conhecimentos teóricos e metodológicos para aprofundar o domínio concreto dos descritores, conduzindo com maior clareza a temática.

Introduction: Knowledge on the profile, nutritional status, eating habits, and degree of customer satisfaction are essential for the collective food sector. Objective: To evaluate the production, waste, and satisfaction regarding vegetarian preparations at a university. Methods: This cross-sectional study was carried out in a university restaurant in Espírito Santo state; the one on campus A served lunch to health workers and students and the one on campus B, lunch and dinner for students from other areas. Data collection took place in eight days at the restaurant on campus A and in 20 days on campus B, comprising the measurement of food production, waste, and acceptability. Results: We found that the average leftover portions were 43 34 on campus A and 546 114 and 36 42 at lunch and dinner on campus B, respectively. The average quantity of food waste per customer was equal to 29.0 9.9 g on campus A and 29.1 5.5 g and 18.7 3.8 g at lunch and dinner on campus B, respectively. In 64.7% of the days evaluated, the quantity of food waste per capita was above the recommended. As to the acceptability of vegetarian dishes on campus A, Eggplant Parmigiana had the highest overall acceptance (84.4%) and Textured Soybean Protein with Vegetables (68.89%) the lowest. On campus B, the most accepted preparation was Kibbeh with Pumpkin (87.6%) and the least accepted, Polenta with Textured Soybean Protein (71.4%). Conclusions: Despite the waste, the acceptability of the preparations was satisfactory, and these indicators should be continuously monitored.

Introduction: Rosacea is a chronic inflammatory skin disease. The intradermal application of botulinum toxin (BT) has been studied as a therapeutic option for patients who struggle to manage flushing and/or persistent facial erythema. There is no standard protocol for BT application in rosacea. Objective: To evaluate the effectiveness of botulinum toxin application on erythematotelan-giectatic rosacea. Methods: Pilot study with case series. We applied intradermal BT in 10 patients with a diagnosis of rosacea and symptoms of persistent erythema and/or facial flushing. Patients received 10 to 15 injections per hemiface (1 unit of onabotulinum BT per injection) and 0 to 5 injections in the nasal region, totaling 25 to 35 units per patient. Results: Seventy-five percent of the patients presented a reduction in flush and erythema intensity. The follow-up time was three months, and no serious adverse events were observed. Conclusions: The therapeutic arsenal to control erythema and facial flushing of rosacea, especially refractory to the usual treatment, should consider the intradermal application of BT type A.

Introdução: A pandemia COVID-19 veio comprometer o acompanhamento periódico dos doentes hipertensos em diversos aspetos. Este cenário fez com que se privilegiassem estratégias de telessaúde, como as plataformas mHealth, que constituem vias alternativas de promoção da autogestão destes doentes. Porém, não existe informação significativa que comprove o seu nível de efetividade. O objetivo deste estudo foi realizar uma revisão sistemática baseada na evidência sobre o papel de plataformas através do telemóvel ou smartphone na adesão de indivíduos com hipertensão ao plano terapêutico proposto. Métodos: Os artigos desta revisão foram obtidos através da pesquisa bibliográfica em diferentes plataformas científicas, aplicando-se os termos MeSH mobile, phone, hypertension e adherence. Foram incluídos estudos segundo os critérios definidos pelo modelo PICOS: (P) indivíduos adultos com diagnóstico de hipertensão arterial, a realizar pelo menos um fármaco anti-hipertensor; (I) plano terapêutico reforçado com recurso ao telemóvel, telefone fixo ou smartphone; (C) standard care; (O) alterações na adesão terapêutica; (S) revisões sistemáticas e ensaios clínicos aleatorizados controlados. Foi utilizada a escala Strength of Recommendation Taxonomy, da American Academy of Family Physicians, para avaliação dos níveis de evidência e atribuição de forças de recomendação. Resultados: Dos 729 artigos iniciais foram apenas incluídos sete estudos para a realização desta revisão: uma revisão sistemática e seis ensaios clínicos aleatorizados controlados. Apesar dos estudos relatarem resultados algo heterogéneos e inconsistentes, na generalidade apresentam resultados estatisticamente significativos no sentido do aumento de adesão terapêutica. No entanto, o risco de viés foi relativamente alto. Conclusões: A evidência atual é de qualidade moderada, algo inconsistente e de difícil generalização, apesar de favorável à efetividade destas plataformas na adesão terapêutica em doentes hipertensos (força de recomendação B). Existe necessidade de maior uniformização e adaptabilidade nos métodos de avaliação da adesão à terapêutica para aumentar a comparabilidade entre estudos e analisar a evolução e tendências numa determinada população.

Abstract Background 12q14 microdeletion syndrome is characterized by low birth weight and failure to thrive, proportionate short stature and developmental delay. The opposite syndrome (microduplication) has not yet been characterized. Our main objective is the recognition of a new clinical entity - 12q14 microduplication syndrome. - as well as confirming the role of HMGA2 gene in growth regulation. Case presentation Array Comparative Genomic Hybridization (CGH), Karyotype, Fluorescence in situ Hybridization, Quantitative-PCR analysis and Whole exome sequencing (WES) were performed in a girl presenting overgrowth and obesity. Array CGH identified a 1.5 Mb 12q14.3 microduplication involving HMGA2, GRIP1, IRAK3, MSRB3 and TMBIM4 genes. Karyotype and FISH showed that duplication was a de novo insertion of 12q14.3 region on chromosome 9p resulting in an interstitial microduplication. Q-PCR confirmed the duplication only in the proband. WES revealed no pathogenic variants. Conclusions Phenotypic comparison with patients with 12q14 microdeletion syndrome showed a reciprocal presentation, suggesting a phenotypically recognizable 12q14 microduplication syndrome as well as confirming the role of HMGA2 gene in growth regulation. It is also indicative that other genes, such as IRAK3 and MSRB3 might have of role in weight gain and obesity.

Entende-se a alimentação como parte do cuidado integrado à saúde, uma vez que é indubitável a sua relação com o bem-estar físico e mental do indivíduo. Sendo assim, observa-se que, apesar de pouco mencionado e divulgado, o consumo de alguns alimentos influencia diretamente no surgimento de transtornos mentais em virtude dos componentes nutricionais presentes nos mesmos. Diante disso, o objetivo do presente trabalho é comparar alguns nutrientes específicos (o ômega-3 e o triptofano) com transtornos mentais singulares (a depressão, ansiedade e a esquizofrenia), de modo a demonstrar a relação que cada substância tem em cada transtorno específico e exaltar a influência da dieta como precursora de doenças. Para a realização deste estudo foi feita uma pesquisa nos bancos de dados Scielo e PubMed. Nos dois artigos selecionados acerca do aminoácido triptofano observou-se melhoria nos experimentos com ratos que ingeriram a substância ao comparar com os que não receberam nenhum tratamento. Além disso, estudos realizados também com L-triptofano concluíram que essa substância exerceu efeito antidepressivo. Já estudos que tomaram o ômega-3 como base para dietas no intuito de reduzir significativamente o nível de ansiedade dos participantes não mostraram eficácia da substância. O mesmo ocorreu em trabalhos considerando seu efeito na esquizofrenia, visto que as respostas não foram conclusivas e sólidas o bastante. Entretanto, em outra pesquisa aplicada tendo como base a influência do ômega-3 na depressão observou-se que houve diminuição significativa dos sintomas depressivos. Conclui-se, portanto, que é indiscutível a influência da alimentação nos transtornos mentais, mas são necessários mais estudos sejam realizados a fim de assegurar a relação de alguns nutrientes com essas doenças.

The internationalization of science and technology (S&T) has been a subject of extreme relevance and relevance in the contemporary context. This text aims to produce reflective knowledge about this process of internationalization of research groups and national scientific production, focusing on bioenergy research groups. We propose to investigate the conflicts, the interests that mobilize the constitution of the networks. Our methodology is based on qualitative data collection, using semi-structured interviews guided by a basic script. The interviewees were selected from individual and collective involvement with international research networks in the area of energy. Besides the interviews projects and research reports made available by the groups and their scientific production available on platforms were analyzed. We found a cleavage between national and international scientific activities, with distinct levels of validation and scientific recognition of researchers at both poles, as well as an internal process of intellectual extroversion and not only of cognitive and scientific imposition between nations.

A aplicação de toxina botulínica nos pacientes com sequela de paralisia de Bell é uma terapia auxiliar de extrema valia para a redução da sincinesia e de assimetrias faciais. A paralisia de Bell é a causa mais comum de paralisia do neurônio motor facial. Após a fase de paralisia dos músculos da face, o quadro pode evoluir com assimetria facial e sincinesia. No tratamento da sincinesia, as injeções pontuais no músculo orbicular e platisma aliviam os espasmos. A aplicação seletiva na hemiface não acometida objetiva reduzir a assimetria facial e seu impacto social negativo, com melhora da qualidade de vida.

Resumo Introdução A utilização de indicadores válidos na avaliação do estado nutricional populacional é muito importante. Objetivo Avaliou-se a concordância entre medidas aferidas e autorrelatadas de peso corporal, estatura e IMC, e identificou-se fatores que exercem influência sobre o autorrelato. Método Estudo transversal de base populacional de adultos da Região Metropolitana de SP (N=766). Cálculo dos coeficientes de correlação intraclasse e análises gráficas de Bland & Altman foram conduzidos, avaliando a concordância dessas medidas. Resultados Na amostra total, e para ambos os sexos, foram subestimados o peso corporal autorrelatado e, consequentemente, o IMC, enquanto a estatura autorrelatada foi superestimada. A imprecisão no autorrelato foi influenciada pelo sexo, idade, escolaridade e estado nutricional. A confiabilidade encontrada entre as medidas foi elevada em ambos os sexos e na amostra total (peso corporal CCI 0,951/IC 0,938-0,961; estatura CCI 0,870/IC 0,597-0,939; IMC CCI 0,865/IC 0,677-0,928). A prevalência de excesso de peso pelas medidas autorrelatadas mostrou-se subestimada (13%), quando comparada àquela calculada através das medidas aferidas. Conclusão O autorrelato pode ser influenciado por diversos fatores, produzindo medidas imprecisas. Sua utilização em inquéritos populacionais pode acarretar em uma importante subestimativa do risco de adoecimento e mortalidade prematura por doenças cardiovasculares e metabólicas associados ao excesso de peso.

Introduction Studies which focus on the process of acculturation in the lifestyles, nutritional status and health of immigrants from the Community of Portuguese-Speaking Countries (CPLP) in the Iberian Peninsula are still scarce. This study aims to explore the influence of the acculturation process and dietary acculturation on the lifestyle and nutritional and health status of CPLP immigrants in Portugal and Spain, focusing on two Iberian contexts: Lisbon Metropolitan Area and the Basque Country.Methods and analysis A mixed methods sequential explanatory design, combining cross-sectional studies and semistructured interviews. Official data will also be analysed. Primary data will be collected through a questionnaire and assessment of nutritional status and body composition. The estimated samples sizes are 1061 adults (≥18 years old) in the Lisbon Metropolitan Area and 573 in the Basque Country. Time-location sampling will be used for the quantitative component and non-probabilistic sampling for the qualitative component. If safety conditions are not guaranteed due to the COVID-19 pandemic, online studies will be conducted. The semistructured interviews will complement the questionnaire data and extend knowledge about the process of acculturation of CPLP immigrants and their relationship with eating habits and physical activity. Thematic analysis will be used for qualitative data. Triangulation of data derived from different methods will be carried out. An integrative approach will be used to address potential discrepancies in findings and limitations inherent to the study design. As inter-method discrepancies may occur, triangulation protocol will be used, elaborating a ‘convergence coding matrix’ to display findings emerging from each component of the study.Ethics and dissemination Ethical approval was obtained through the IHMT Ethics Council (Doc No 20/2020), Portugal, and it was submitted to the Ethics Committee of the UPV/EHU (Doc No under revision), Spain.

The aetiology of pulmonary nodules is varied, with malignant lesions being the most important and requiring rapid diagnosis and treatment. However, although clinical presentation and imaging may suggest a specific diagnosis, it should be kept in mind that some benign pathologies mimic more serious disease. A 50-year-old man presented with left pleuritic chest pain. A CT scan showed an ipsilateral pulmonary spiculated nodule. Pneumonia was assumed and the patient was started on antibiotic therapy. In the absence of improvement, positron emission tomography and a transthoracic aspiration biopsy were performed. Lung cancer was diagnosed and the patient underwent an upper lobectomy. However, examination of the surgical specimen showed no malignancy.

O presente trabalho apresenta os resultados de uma pesquisa desenvolvida no Centro de Referência de Assistência Social - CRAS localizado no município de Eldorado do Sul/RS. A pesquisa buscou investigar aspectos relevantes no ensino e aprendizagem em Ciências da Natureza (Química, Física e Biologia) e saberes da experiência das participantes através da aplicação de uma abordagem temática inspirada em Paulo Freire (1987) em um espaço não formal de ensino. Utilizou-se como instrumento de pesquisa a observação - participante e questionário. A experiência desenvolvida oportunizou a presente reflexão, autocrítica e futuros desafios, tal como pensar como os espaços não formais, como a própria escola pode contribuir como ferramenta de construção de novos paradigmas onde o educando seja o principal motivador-construtor de seus conhecimentos acerca da Ciências da Natureza.

Background: The extraction of impacted mandibular third molars is a frequent dental surgery, interfering with patients’ quality of life. Ultrasonic surgery is an alternative to osteotomy with conventional rotary instruments. This study compares postoperative signals and symptoms after extracting impacted mandibular third molars using ultrasonic surgery or conventional rotary osteotomy. Methods: A pilot randomized controlled clinical trial was conducted. Thirty patients were randomly divided into the test group (ultrasonic technique) and a control group (conventional rotatory technique). All surgeries were timed. Swelling parameters, trismus and paraesthesia were evaluated on the day of surgery and the third, fifth and seventh postoperative days. Intraoperative bleeding was evaluated during surgery. Postoperative pain was evaluated daily by the patient through a visual analogue scale and the number of ingested analgesics. Results: Pain, swelling and trismus present beneficial results with the ultrasonic technique but without statistical significance. Intraoperative bleeding was significantly lower with ultrasonic surgery (t(28) = 3.258; p = 0.003). Operating time was significantly higher in extractions involving osteotomy and cutting crown and roots either with the conventional technique (p = 0.020) or ultrasonic technique (p = 0.039). Regardless of the surgical difficulty, no statistically significant results were detected between techniques regarding the procedure duration. Conclusions: The beneficial postoperative signs and symptoms make ultrasonic surgery a favourable therapeutic option, especially when the integrity of noble anatomical structures is the most important risk factor. Further studies with larger samples are needed to support the use of piezosurgery as a valid option for impacted mandibular third molar extraction.

Introduction: Brazil has presented alarming and growing data on infection and deaths from SARS-CoV-2. There are more than 4 500 000 confirmed cases and more than 137 000 deaths ranking second in the world ranking of infected people. In addition to the involvement of the respiratory, cardiovascular, renal and neurological systems, this virus also causes non-specific skin lesions in same patients. Little is known about the pathophysiology of cutaneous involvement. At this moment, we cannot predict a difference in prognosis based on skin lesions. Methods: We conducted an observational case study of 25 patients affected by SARS-CoV-2 who had dermatological lesions. We described the clinical and epidemiological characteristics of each case, demonstrating the polymorphism of the skin lesions and also making a correlation with the chronology of presented systemic symptoms. Results: Twenty five cases of COVID-19 with cutaneous manifestations (urticaria, erythematous rash, maculopapular eruption, pruritus, erythema multiforme-like lesions, dyshidrotic eczema) were observed during, after and before systemic symptoms. A few cases with skin involvement were also observed as isolated symptoms of the viral infection. These data demonstrate the clinical polymorphism related to skin involvement of patients infected with SARS-CoV-2, emphasizing the importance of clinical suspicion by dermatologists when handling suspected cases in the current epidemiological scenario. Conclusion: Although the number of cases in the world stage seems to be regressing, infection by SARS-CoV-2 will be part of the dermatologist's daily routine. As long as we do not have a widely available vaccine and the pandemic takes on an endemic profile, we need to be aware of these manifestations, not only for the proper diagnosis, indication of patient isolation, as well as all the necessary biosafety procedures in dermatology clinics.

In society energy is the most evident representation of the relationship between technology, economics, and culture and, therefore, formalizes itself in territorial transformations subjugated to the logic of its production, transportation, and consumption. Energy production based on what was the only Portuguese fuel—mineral coal—gave rise to the Carboniferous System of the Douro (Sistema Carbonífero do Douro (SCD)), extending from the social support structures close to the places it was mined to the (infra)structure systems of, and in, Porto (Portugal). Given this system, the relationship of it within the territory takes on particular importance in its understanding as heritage. The system seeks to reach conclusions about the integration of its heritage condition within territorial transformation policies. To do so, it seeks to understand how “structural invariants” which determine nuclei of this system are understood within the scope of the planning instruments and territorial management in force and, therefore, making conclusions regarding the mismatch between the recognition of heritage and its valorization of such as well as the difficulty of creating a prospective heritage understanding. As an alternative, the promotion of inclusive territorial management planning processes, which go beyond municipal management, capable of (re)producing territorializing actions that enhance and support heritage.

Abstract Background Cape Verde presents a high rate of cardiovascular diseases. Low potassium and high sodium intakes are related to cardiovascular diseases. However, studies regarding these two micronutrients continue to be rare in African urban settings. This work aims to estimate potassium and sodium intakes and to analyse the self-reported salt intake by gender and by type of urban area in the city of Praia – the capital of Cape Verde. Methods In the first stage (n = 1912), an intra-urban study was designed in two types of urban areas (formal and informal), using a sampling strategy based on random selection of geographical coordinates, in order to apply a questionnaire. In a second stage, a 24-h dietary recall and anthropometric measurements were performed by local nutritionists. Potassium and sodium intakes were estimated for 599 participants (149 men and 450 women). Non-parametric methods (including quantile regression) were used in the statistical analysis. Results In informal areas, a higher percentage of women reported having hypertension (31.0%) compared to formal areas (19.7%). Based on 24-h dietary recall, median potassium intake for men was 2924.2 mg/day and for women and 2562.6 mg/day. Almost 70.0% of men and 80.0% of women ingested less than the recommended 3510 mg/day of potassium. In informal areas, men and women presented high medians of sodium intakes compared to formal areas (men: 4131.2 vs 3014.6 mg/day and women: 3243.4 vs 2522.4 mg/day). On the other hand, the percentage of participants exceeding 2000 mg/day for sodium was high (≥70.8%), even for participants that self-reported low-salt intake. Quantile regression models revealed effects of the type of urban area and gender in the potassium and sodium intakes, at least, in some quartiles, accounting for age, academic qualifications, and professional situation. Conclusions A low potassium intake and a high sodium intake were found in Praia. Thus, efficient health education campaigns and health promotion are needed and should be tailored considering gender and urban areas.

Portugal and Spain have a cross-border cooperation protocol on wildfires response for a buffer strip of 25 km for each side of the border. In spite of the success of this collaboration, there are issues to be improved, since Portuguese and Spanish authorities use different methodologies to assess the daily fire danger. A methodology to harmonize fire danger and its interpretation by the Portuguese and Spanish Civil protection authorities in the transboundary buffer strip area is hereby presented. The fire danger index used is the Canadian Fire Weather Index (FWI), which requires input from meteorological data and gives an indication of fire intensity. The fire danger class is an important decision support tool for preventing and fighting wildfires. Since the meaning of FWI values change from region-to-region according to its specific characteristics, a calibration process was performed based on statistical data of the daily FWI values, the number of fires and burned area between 2005 and 2013. The results of the FWI calibration and harmonization of the data for the five danger classes minimizes the fire danger discrepancies across the border. This methodology has the potential to be reproduced in other areas.

Maternally inherited diabetes and deafness is a rare form of diabetes caused by a mitochondrial DNA mutation. The index case is a 55-year-old woman who was admitted with hypertrophic cardiomyopathy. She had a history of diabetes mellitus and hearing loss. The patient’s mother, two brothers and two sisters also had a history of diabetes and hearing loss. This pattern suggests a maternally inherited disorder. All siblings carried the A3243G mitochondrial DNA mutation. The identification of people with monogenic forms of diabetes mellitus is a diagnostic challenge. This condition should be considered whenever there is a history of diabetes associated with hearing loss and a relevant family history. Cardiopathy is also known to be an important feature of mitochondrial disease. In order to identify this aetiology, family screening, genetic counselling and screening of associated comorbidities are encouraged.

ABSTRACT CONTEXT AND OBJECTIVE: Uterine fibroids (UF), also known as leiomyomas, are the most prevalent gynecological tumors. The Uterine Fibroid Symptoms and Quality of Life (UFS-QOL) is the only specific questionnaire that assesses symptom intensity and quality-of-life issues for women with symptomatic UF; however, it only exists in the English language. Thus, we aimed to translate and culturally validate the UFS-QOL questionnaire for the Brazilian Portuguese language. DESIGN AND SETTING: Cross-sectional study, Department of Gynecology and Obstetrics, FMRP-USP. METHODS: 113 patients with UF (case group) and 55 patients without UF (control group) were interviewed using the UFS-QOL questionnaire after translation and cultural adaptation. The Short Form-36 questionnaire was used as a control. Demographic and psychometric variables were analyzed. RESULTS: Women with UF presented higher mean age, body mass index, weight, parity and comorbidities than the control group (P < 0.05). The most prevalent complaints were abnormal uterine bleeding (93.8%), pelvic pain (36.3%) and extrinsic compression (10.6%) and these presented adequate construct validity regarding UFS-QOL severity (P < 0.05). The UFS-QOL questionnaire presented good internal consistency regarding symptom severity and quality-of-life-related domains (intraclass correlation coefficient, ICC = 0.82/0.88). Structural validity presented correlation coefficients ranging from 0.59 to 0.91. Test-retest comparison did not show differences among the UFS-QOL subscales. After treatment, women with UF presented improvements on all subscales. CONCLUSION: The UFS-QOL questionnaire presented adequate translation to the Brazilian Portuguese language, with good internal consistency, discriminant validity, construct validity, structural validity and responsiveness, along with adequate test-retest results.

Passive transfer of antibodies secondary to intravenous immunoglobulin infusion is a rare but important side effect that can lead to the wrong diagnosis and therapeutic decisions. It has never been reported in a newborn. A male newborn, vaccinated against hepatitis B and diagnosed with dilated cardiomyopathy, presented positive hepatitis B core antibodies at 12 days of life. Exclusion of hepatitis B infection was mandatory as it would be a contraindication to heart transplant. Passive transfer of antibodies was confirmed at 44 days of age, after seroreversion of hepatitis B core antibodies. Passive transfer of antibodies after intravenous immunoglobulin infusion can lead to a misleading diagnosis if not recognized. In our patient it could have been especially harmful had it prevented heart transplant. Screening for hepatitis B should be performed at least 1 month after intravenous immunoglobulin infusion.

Resumo: O objetivo foi avaliar o efeito da exposição e do tempo de exposição ao aleitamento materno na ocorrência de transtornos mentais comuns (TMC) entre adolescentes escolares brasileiros. Este trabalho analisou dados do Estudo de Riscos Cardiovasculares em Adolescentes (ERICA), avaliando aqueles que tiveram o questionário referente ao aleitamento materno respondido pelos pais ou responsáveis. A presença de TMC foi identificada pelo General Health Questionnaire, versão 12 itens (GHQ-12), considerando-se dois pontos de corte (escores ≥ 3 e ≥ 5). As associações foram testadas em análises bivariadas e por meio de modelos de regressão logística múltipla, com ajustes por variáveis potenciais de confusão. Dentre os 41.723 adolescentes avaliados, a maioria foi composta por estudantes do sexo feminino (54,6%), que tinham idades entre 12 e 15 anos (71%), estudavam em escolas públicas (83,1%), residiam na Região Sudeste (51,9%) e eram das classes econômicas B (53,8%) e C (34,1%). Cerca de metade das mães dos adolescentes não tinha o ensino médio completo (51,7%). O grupo de adolescentes com mais de seis meses de aleitamento materno (51,8%) apresentou uma menor prevalência de TMC para os dois pontos de corte do GHQ-12 avaliados, quando comparado com o grupo que não recebeu aleitamento materno ou que o recebeu por período ≤ 1 mês (RI = 0,82; IC95%:0,69-0,97 e RI = 0,74; IC95%: 0,59-0,91 para 3 e 5 pontos, respectivamente). O aleitamento materno prolongado parece desempenhar um papel protetor para a ocorrência de TMC na adolescência.

En este artículo, la trilogía enseñanza, investigación y extensión constituye el eje por lo que se desarrolla un análisis histórico, buscando ubicar su génesis, como práctica institucional, en el contexto particular de la Universidade Federal de Viçosa (UFV ) y en contraposición al significado fijado a nivel nacional, como principio que direcciona actualmente el estándar de calidad de las universidades brasileñas. El enfoque histórico propuesto bajo estos dos distintos niveles analíticos propició identificar la diferencia entre el sentido funcionalizado que condujo la triología que caracteriza el proyecto institucional de origen de la UFV, inspirado en modelo de los land grant colleges, y el sentido social y político que la triología viene a significar a las universidades brasileñas a partir de su afirmación como principio consti ‑ tucional desde 1988.

Este trabalho é resultante de uma pesquisa de Mestrado que teve por objetivo central analisar em que medida experiências vivenciadas por professores supervisores do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) tem gerado contributos para a formação permanente do professorado e para o desenvolvimento profissional dos docentes. A pesquisa contou com a colaboração de treze professores vinculados à supervisão do PIBID ligado a uma importante Universidade de Minas Gerais. Trata-se de um estudo exploratório, com abordagem qualitativa, orientada por um roteiro semiestruturado de entrevista. Os resultados nos levaram a conclusão de que o referido programa tem proporcionado aos docentes efetiva formação permanente e contribuído para o desenvolvimento profissional dos profissionais.

The rise in antibiotic resistance coupled with the gap in the discovery of active molecules has driven the need for more effective antimicrobials while focusing the attention into the repurpose of already existing drugs. Here, we evaluated the potential antibacterial activity of one cobalt and two zinc metallic compounds previously reported as having anticancer properties. Compounds were tested against a range of Gram-positive and -negative bacteria. The determination of the minimum inhibitory and bactericidal concentrations (MIC/MBC) of the drugs were used to assess their potential antibacterial activity and their effect on bacterial growth. Motility assays were conducted by exposing the bacteria to sub-MIC of each of the compounds. The effect of sub-MIC of the compounds on the membrane permeability was measured by ethidium bromide (EtBr) accumulation assay. Cell viability assays were performed in human cells. Compound TS262 was the most active against the range of bacteria tested. No effect was observed on the motility or accumulation of EtBr for any of the bacteria tested. Cell viability assays demonstrated that the compounds showed a decrease in cell viability at the MIC. These results are promising, and further studies on these compounds can lead to the development of new effective antimicrobials.

IntroductionIbrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction.MethodsWe aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials.gov. The data were pooled using random-effects meta-analyses using the risk ratio (RR) with the 95% confidence interval (95%CI). The confidence on the pooled estimates was ascertained through the grading of recommendations assessment, development, and evaluation (GRADE) approach.ResultsThere were 8 eligible RCTs (2580 patients), all reporting safety data of interest. Ibrutinib was associated with a significant increase in the risk of hypertension with a RR of 2.82 (95%CI 1.52-5.23) with moderate quality evidence. Ibrutinib increased significantly the risk of atrial fibrillation with a RR of 4.69 (95%CI 2.17-7.64) with high quality evidence.ConclusionsIbrutinib was associated with significantly increased risks of both hypertension and atrial fibrillation.

Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) and Nucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur.

Objetivo: Apresentar as percepções de profissionais de saúde e da população em geral com relação à forma de obtenção de órgãos, em especial a abordagem de mercado. Métodos: Buscamos apresentar os dados relativos à percepção dos participantes de forma desinteressada e com a inclusão do envolvimento de necessidade pessoal ou familiar para obtenção de órgãos para fins de transplante, utilizando a abordagem de mercado. Para atender aos objetivos deste estudo, foi elaborado um questionário para coletar a opinião dos participantes. Sua distribuição foi realizada pessoalmente de forma aleatória, e também foi elaborada uma versão eletrônica divulgada via página no Facebook. A análise das respostas obtidas foi discutida ao nível de 5% de significância e consideradas significativas quando o valor de p foi

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