19 results on '"Daniel Peris"'
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2. Statistical Methods for Quality Equivalence of Topical Products. 0.5 mg/g Betamethasone Ointment as a Case-Study
- Author
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Jordi Ocaña, Toni Monleón-Getino, Virginia Merino, Daniel Peris, and Lluís Soler
- Subjects
Fieller’s confidence interval ,equivalence test ,batch effect ,multiple quality variables ,principal component analysis ,Pharmacy and materia medica ,RS1-441 - Abstract
This study examines the statistical implications, and their possible implementation, of the “Draft guideline on quality and equivalence of topical products” issued by the European Medicines Agency in 2018, with particular focus on the section devoted to quality equivalence of physical properties. A new confidence interval to conduct the quality equivalence test and a way to cope with the multiplicity of quality parameters are presented and discussed. As an example, the results and the statistical analysis of a study on betamethasone 0.5 mg/g ointment are presented. It is suggested that the equivalence limits proposed in the draft guideline are overly strict: It is as difficult to declare quality equivalence between two packaging formats of the same reference product as to declare quality equivalence between the reference and the test product.
- Published
- 2020
- Full Text
- View/download PDF
3. Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence
- Author
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Víctor Mangas-Sanjuán, María Pleguezuelos-Villa, Matilde Merino-Sanjuán, Mª Jesús Hernández, Amparo Nácher, Alfredo García-Arieta, Daniel Peris, Irene Hidalgo, Lluís Soler, Marta Sallan, and Virginia Merino
- Subjects
microstructure ,rheology ,equivalence ,generic semisolid formulation ,topical drug ,inter-batch variability ,Pharmacy and materia medica ,RS1-441 - Abstract
Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was to compare the microstructure-defining physical parameters of different batches of a reference ointment containing calcipotriol and betamethasone (Daivobet 50 µg/0.5 mg/g) in order to define the acceptance range that allows concluding equivalence between these batches. Being batches of the same reference product, they are expected to be clinically equivalent and possess similar microstructure. The 90% confidence intervals for the test/reference ratio of these physical parameters were calculated with parametric and non-parametric approaches. Both methods conclude that equivalent microstructure between batches cannot be demonstrated with a reasonable sample size when the acceptance range was set at ±10%, since several physical parameters exhibit inter-batch variability >10%. An acceptance range of ±10% is therefore too strict to conclude equivalence in the microstructure of semisolid dosage forms, given the inter-batch variability observed between batches of the reference product. A wider fixed acceptance range or an acceptance range widened based on the inter-batch variability of the reference product would be advisable.
- Published
- 2019
- Full Text
- View/download PDF
4. Custiniana: The Many Histories of a Single Trip to Russia 180 Years Ago, and Why It Matters Today
- Author
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Daniel Peris
- Subjects
Cultural Studies ,History ,Economic history - Published
- 2021
- Full Text
- View/download PDF
5. The Ownership Dividend : The Coming Paradigm Shift in the U.S. Stock Market
- Author
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Daniel Peris and Daniel Peris
- Subjects
- Stocks--United States, Dividends--United States, Investment analysis--United States
- Abstract
We are on the verge of a major paradigm shift for investors in the U.S. stock market. Dividend-focused stock investing has been receding in popularity for more than three decades in the U.S.; once the dominant investment style, it is now a boutique approach. That is about to change.The Ownership Dividend explains how and why the stock market drifted away from a mostly cash-based returns system to one almost completely driven by near-term share price movements. It details why the exceptional forces behind that shift—notably the 40-year drop in interest rates and the rise of buybacks—are now substantially exhausted. As a result, the U.S. market is poised for a return to the more typical business-like relationships observed in the private sector and in other mature markets around the world. While many market participants have profited from and become used to the way things have been in recent decades, savvy individual investors, financial advisors, and even institutional portfolio managers will want to position themselves to benefit from the reversion to cash-based investment relationships in the years ahead. This is a must-read book for financial advisors, institutional consultants, as well as engaged individual investors.
- Published
- 2024
6. Erratum: Mangas-Sanjuán, V.; et al. Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence. Pharmaceutics 2019, 11, 503
- Author
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Amparo Nácher, Irene Hidalgo, Lluís Soler, María Pleguezuelos-Villa, Matilde Merino-Sanjuán, Victor Mangas-Sanjuan, Mᵃ Jesús Hernández, Alfredo García-Arieta, Daniel Peris, Virginia Merino, and Marta Sallan
- Subjects
lcsh:Pharmacy and materia medica ,n/a ,Published Erratum ,Pharmaceutical Science ,Thermodynamics ,Pharmaceutics ,lcsh:RS1-441 ,Erratum ,Microstructure ,Equivalence (measure theory) ,Mathematics - Abstract
Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was to compare the microstructure-defining physical parameters of different batches of a reference ointment containing calcipotriol and betamethasone (Daivobet 50 µg/0.5 mg/g) in order to define the acceptance range that allows concluding equivalence between these batches. Being batches of the same reference product, they are expected to be clinically equivalent and possess similar microstructure. The 90% confidence intervals for the test/reference ratio of these physical parameters were calculated with parametric and non-parametric approaches. Both methods conclude that equivalent microstructure between batches cannot be demonstrated with a reasonable sample size when the acceptance range was set at ±10%, since several physical parameters exhibit inter-batch variability10%. An acceptance range of ±10% is therefore too strict to conclude equivalence in the microstructure of semisolid dosage forms, given the inter-batch variability observed between batches of the reference product. A wider fixed acceptance range or an acceptance range widened based on the inter-batch variability of the reference product would be advisable.
- Published
- 2020
7. Statistical Methods for Quality Equivalence of Topical Products. 0.5 mg/g Betamethasone Ointment as a Case-Study
- Author
-
Toni Monleón-Getino, Lluís Soler, Virginia Merino, Jordi Ocaña, and Daniel Peris
- Subjects
Operations research ,principal component analysis ,Pharmaceutical Science ,lcsh:RS1-441 ,Batch effect ,030226 pharmacology & pharmacy ,01 natural sciences ,Article ,lcsh:Pharmacy and materia medica ,010104 statistics & probability ,03 medical and health sciences ,0302 clinical medicine ,Equivalence test ,medicine ,Statistical analysis ,0101 mathematics ,Equivalence (measure theory) ,Administration of drugs ,Mathematics ,batch effect ,Fieller's confidence interval ,Guideline ,Confidence interval ,Cortisone ,Reference product ,Estudi de casos ,Cortisona ,equivalence test ,Fieller’s confidence interval ,Betamethasone ,Administració de medicaments ,Case studies ,multiple quality variables ,medicine.drug - Abstract
This study examines the statistical implications, and their possible implementation, of the &ldquo, Draft guideline on quality and equivalence of topical products&rdquo, issued by the European Medicines Agency in 2018, with particular focus on the section devoted to quality equivalence of physical properties. A new confidence interval to conduct the quality equivalence test and a way to cope with the multiplicity of quality parameters are presented and discussed. As an example, the results and the statistical analysis of a study on betamethasone 0.5 mg/g ointment are presented. It is suggested that the equivalence limits proposed in the draft guideline are overly strict: It is as difficult to declare quality equivalence between two packaging formats of the same reference product as to declare quality equivalence between the reference and the test product.
- Published
- 2020
8. Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence
- Author
-
Alfredo García-Arieta, Virginia Merino, Marta Sallan, Matilde Merino-Sanjuán, Lluís Soler, María Pleguezuelos-Villa, Mª Jesús Hernández, Victor Mangas-Sanjuan, Daniel Peris, Amparo Nácher, and Irene Hidalgo
- Subjects
microstructure ,equivalence ,lcsh:RS1-441 ,Pharmaceutical Science ,generic semisolid formulation ,02 engineering and technology ,030226 pharmacology & pharmacy ,Dosage form ,Article ,lcsh:Pharmacy and materia medica ,03 medical and health sciences ,0302 clinical medicine ,topical drug ,Statistics ,inter-batch variability ,Equivalence (measure theory) ,Parametric statistics ,Mathematics ,021001 nanoscience & nanotechnology ,Microstructure ,Confidence interval ,Reference product ,Sample size determination ,Drug release ,rheology ,0210 nano-technology - Abstract
Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was to compare the microstructure-defining physical parameters of different batches of a reference ointment containing calcipotriol and betamethasone (Daivobet 50 µ, g/0.5 mg/g) in order to define the acceptance range that allows concluding equivalence between these batches. Being batches of the same reference product, they are expected to be clinically equivalent and possess similar microstructure. The 90% confidence intervals for the test/reference ratio of these physical parameters were calculated with parametric and non-parametric approaches. Both methods conclude that equivalent microstructure between batches cannot be demonstrated with a reasonable sample size when the acceptance range was set at ±, 10%, since several physical parameters exhibit inter-batch variability >, 10%. An acceptance range of ±, 10% is therefore too strict to conclude equivalence in the microstructure of semisolid dosage forms, given the inter-batch variability observed between batches of the reference product. A wider fixed acceptance range or an acceptance range widened based on the inter-batch variability of the reference product would be advisable.
- Published
- 2019
9. Getting Back to Business: Why Modern Portfolio Theory Fails Investors and How You Can Bring Common Sense to Your Portfolio
- Author
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Daniel Peris and Daniel Peris
- Subjects
- Portfolio management, Investments
- Abstract
Modern Portfolio Theory has failed investors. A change in direction is long overdue. We are in a time of enormous risk. Economic growth is anemic, and political risk to the capital markets is on the rise. In the U.S., a generation of white collar baby-boomers is heading into retirement with insufficient assets in their 401(k) programs, and industrial workers are stuck with materially underfunded pension plans. Against that backdrop, the investing industry's current set of practices and assumptions—Modern Portfolio Theory (MPT)—is based on a half-century old formula that is supposed to deliver the maximum amount of return for a given amount of risk. The trouble is that it doesn't work very well. In Getting Back to Business, dividend-investing guru Daniel Peris proposes a radical new approach—radical in that it does away with MPT in favor of a more intuitive, common-sense approach practiced by business people in their own affairs everyday: cash returns on cash investments. “In a profession utterly lacking a historical sensibility,” Peris writes. “One periodically needs to ask why we do things the way we do, how we got here, and whether perhaps there is a better way.” Balancing detailed historical evidence with a practitioner's real-world expertise, Peris asks the right questions—and provides a solution that makes sense in today's challenging investing landscape.
- Published
- 2018
10. The Dividend Imperative: How Dividends Can Narrow the Gap Between Main Street and Wall Street
- Author
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Daniel Peris and Daniel Peris
- Abstract
IF YOU'RE INVESTED IN THE FUTURE OF THE STOCK MARKET, THIS IS YOUR WAKE-UP CALL. You've seen the markets swing from bubble to scandal and back again. You've watched the divide between Wall Street and Main Street grow larger each year. You've wished there was a strategic approach to investing that strengthened portfolios, benefited companies, and bolstered the economy as well. The answer, according to business investor Daniel Peris, is simple. You need to focus on dividends. Investors need to demand bigger dividends and U.S. corporations need to pay out more of their profits as dividends. This is THE DIVIDEND IMPERATIVE. A powerful new call to action for investors and corporate leaders by the acclaimed author of The Strategic Dividend Investor “Peris makes a compelling case that investors and companies need to focus more on dividends, which have accounted for the lion's share of stock market returns.” —John Heinzl, Toronto Globe & Mail “All investors and corporate leaders can benefit from Peris's simple insight.” —J. Christopher Donahue, CEO, Federated Investors
- Published
- 2013
11. The Dividend Investor and Imperative EBOOK BUNDLE
- Author
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Daniel Peris and Daniel Peris
- Abstract
TWO E-BOOKS IN ONE The Strategic Dividend Investor Responsible for $4.5 billion in dividend-anchored portfolios, Daniel Peris demonstrates that, for most investors, buying a stock in the hope of making a quick buck by selling it in a few weeks or months is far from the best way to create wealth. Instead, you should use the stock market as a means of receiving a share of excess profits—dividends—from corporations in which you own stock. Over time, those payments—and the growth of those payments—represent the vast majority of stock market returns. The Dividend Imperative The The Dividend Imperative, a bold new vision for anyone interested in having a stronger, broader, and healthier stock market for everyone. If you're invested in the future of the stock market, this is your wake-up call. Dividends are not the problem. They're part of the solution.
- Published
- 2013
12. 'God is Now on Our Side': The Religious Revival on Unoccupied Soviet Territory during World War II
- Author
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Daniel Peris
- Subjects
Cultural Studies ,History ,World War II ,Interwar period ,Ancient history - Published
- 2000
- Full Text
- View/download PDF
13. The Strategic Dividend Investor
- Author
-
Daniel Peris and Daniel Peris
- Subjects
- Investment analysis, Dividends
- Abstract
TIRED OF THE STOCK MARKET'S UPS AND DOWNS? Get off the Wall Street roller coaster with strategic dividend investing! There's a big difference between investing in the stock market and investing in companies through the stock market.The Strategic Dividend Investor shows you why, over the long run, investing in companies with high and rising distributions is far superior to'playing the market.'Responsible for $4.5 billion in dividend-anchored portfolios, Daniel Peris demonstrates that, for most investors, buying a stock in the hope of making a quick buck by selling it in a few weeks or months is far from the best way to create wealth. Instead, you should use the stock market as a means of receiving a share of excess profits—dividends—from corporations in which you own stock. Over time, those payments—and the growth of those payments—represent the vast majority of stock market returns. The Strategic Dividend Investor outlines the key issues you need to address in order to create a solid dividend portfolio, including how to: View the stock market as a business venture rather than as a platform for speculation Strike the right balance between current yield and dividend growth Learn to assess the ability and inclination of a company to pay and increase its dividends over time The real key to mastering the stock market is to take the stock out of the equation and treat your outlay as you would any other business investment—with an eye to the long term and to cash returns. By contrast, the'buy low, sell high, repeat frequently'philosophy foisted on the investing public has been wrecking portfolios on Main Street for decades, all the while generating big profits for Wall Street. But after a decade of mediocre returns from the stock market—highlighted by two dramatic crashes—now is the time to refocus your portfolio on dividends, and The Strategic Dividend Investor will show you how. Praise for The Strategic Dividend Investor'Peris is way out in front of the Wall Street pack. His book makes a case for dividend-driven investing that no one in this back-to-basics era should ignore.'Josh Peters, Editor, The Morningstar Dividend Investor'Peris is a leading portfolio manager in the dividend investing space, and his results and insights add tremendous value to any portfolio. Whether you're an individual investor or an institution portfolio manager, The Strategic Dividend Investor is an absolute must read in this challenging market environment.'Don Dion, President, Dion Money Management, and Editor, The Fidelity Independent Adviser'In this lively and persuasive polemic, Daniel Peris forcefully reminds us what equity investing is really all about: SHOW ME THE MONEY!'Ian Kennedy, former Director of Research, Cambridge Associates'[Makes] the strongest cases I've ever seen for relentlessly investing in dividend stocks and funds that own them.'Kiplinger's
- Published
- 2011
14. Commissars in Red Cassocks: Former Priests in the League of the Militant Godless
- Author
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Daniel Peris
- Subjects
Cultural Studies ,Arts and Humanities (miscellaneous) ,Militant ,Political science ,05 social sciences ,050602 political science & public administration ,0507 social and economic geography ,Ethnology ,League ,050701 cultural studies ,Humanities ,0506 political science - Abstract
La suppression de l'Eglise orthodoxe russe par les communistes apres la Revolution de 1917 se revele insuffisante pour parvenir au but que se sont fixe les bolcheviks: une russie secularisee, une societe athee. Dans les anees 1920, le Parti communiste organise une campagne de propagande anti-religieuse. C'est la Ligue des athees qui est chargee de ce travail. D'anciens membres du clerge orthodoxe participent a la Ligue. L'A. s'attache a leur role au niveau central, mais egalement dans la region de Iaroslav
- Published
- 1995
- Full Text
- View/download PDF
15. The 1929 congress of the Godless
- Author
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Daniel Peris
- Subjects
Economics and Econometrics ,History ,Sociology and Political Science ,media_common.quotation_subject ,Geography, Planning and Development ,League ,Politics ,Political science ,Political economy ,Social transformation ,Secularization ,Rhetorical question ,General Earth and Planetary Sciences ,Political culture ,Ideology ,Atheism ,General Environmental Science ,media_common - Abstract
AMONG THE MANY social campaigns launched in the Soviet Union in the 1920s, the effort to counter the pervasive influence of religion was among the most visible. Examining how the Bolsheviks sought to introduce atheism into Holy Russia sheds light not only on Bolshevik strategies for planned secularisation, but also on the evolving Soviet political culture. Both of these subjects can be approached through analysis of the stenographic report of the June 1929 Congress of the League of the Godless (Soyuz bezbozhnikov), the quasi-governmental organisation charged with eradicating religion.1 This document serves as a window through which we observe the repeated clashes of two distinct and opposed camps promoting conflicting views on how the anti-religious campaign ought to be run. More importantly, the stenographic report highlights the shared assumptions and rhetorical conventions of the coalescing political culture in which the congress occurred and which qualitatively altered the character of the anti-religious debate. This article first reviews the 12 years of anti-religious history prior to the congress. It then examines the divisions at the congress along ideological and institutional lines. The third section discusses those elements of the emerging political culture evident in the debate; finally, the conflicts in the anti-religious camp are linked to the broader political and social transformation engulfing Soviet society on the cusp of Stalin's revolution.
- Published
- 1991
- Full Text
- View/download PDF
16. Storming the Heavens
- Author
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Daniel Peris
- Published
- 1998
- Full Text
- View/download PDF
17. Storming the Heavens: The Soviet League of the Militant Godless
- Author
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William B. Husband, Daniel Peris, and Bruce Grant
- Subjects
Cultural Studies ,Linguistics and Language ,Literature and Literary Theory ,Militant ,Political science ,League ,Religious studies ,Language and Linguistics - Published
- 2001
- Full Text
- View/download PDF
18. Storming the Heavens: The Soviet League of the Militant Godless
- Author
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Larry E. Holmes and Daniel Peris
- Subjects
Archeology ,History ,Museology - Published
- 1999
- Full Text
- View/download PDF
19. The Party of Unbelief: The Religious Policy of the Bolshevik Party, 1917- 1929
- Author
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Daniel Peris and Arto Luukkanen
- Subjects
Archeology ,History ,Museology - Published
- 1996
- Full Text
- View/download PDF
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