20 results on '"Daniel Marten"'
Search Results
2. P575: The Rare Genomes Project: Improving access to genomic sequencing and identifying causes of rare disease
- Author
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Christina Austin-Tse, Stephanie DiTroia, Melanie O'Leary, Grace VanNoy, Brian Mangilog, Gulalai Shah, Eva Martinez, Jillian Serrano, Lynn Pais, Emily O'Heir, Ikeoluwa Osei-Owusu, Gabrielle Lemire, Vijay Ganesh, Sarah Stenton, Mutaz Amin, Kayla Socarras, Mugdha Singh, Stacey Hall, Katie Larsson, Moriel Singer-Berk, Daniel Marten, Michael Wilson, Hana Snow, Benjamin Blankenmeister, Jialan Ma, Ben Weisburd, Alba Sanchis-Juan, Harrison Brand, Emily Groopman, Alysia Lovgren, Clara Williamson, Marissa Hollyer, Eleina England, Eleanor Seaby, Katherine Chao, Julia Goodrich, Samantha Baxter, Daniel MacArthur, Michael Talkowski, Monica Wojcik, Anne O'Donnell-Luria, and Heidi Rehm
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Genetics ,QH426-470 ,Medicine - Published
- 2024
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3. Implicit and explicit learning in reactive and voluntary saccade adaptation.
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Daniel Marten van Es and Tomas Knapen
- Subjects
Medicine ,Science - Abstract
Saccades can either be elicited automatically by salient peripheral stimuli or can additionally depend on explicit cognitive goals. Similarly, it is thought that motor adaptation is driven by the combination of a more automatic, implicit process and a more explicit, cognitive process. However, the degree to which such implicit and explicit learning contribute to the adaptation of more reactive and voluntary saccades remains elusive. To study this question, we employed a global saccadic adaptation paradigm with both increasing and decreasing saccade amplitudes. We assessed the resulting adaptation using a dual state model of motor adaptation. This model decomposes learning into a fast and slow process, which are thought to constitute explicit and implicit learning, respectively. Our results show that adaptation of reactive saccades is equally driven by fast and slow learning, while fast learning is nearly absent when adapting voluntary (i.e. scanning) saccades. This pattern of results was present both when saccade gain was increased or decreased. Our results suggest that the increased cognitive demands associated with voluntary compared to reactive saccade planning interfere specifically with explicit learning.
- Published
- 2019
- Full Text
- View/download PDF
4. Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention
- Author
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Daniel Marten van Es, Jan Theeuwes, and Tomas Knapen
- Subjects
spatial attention ,feature-based attention ,population receptive fields ,fMRI ,vision ,attention ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Spatial attention changes the sampling of visual space. Behavioral studies suggest that feature-based attention modulates this resampling to optimize the attended feature's sampling. We investigate this hypothesis by estimating spatial sampling in visual cortex while independently varying both feature-based and spatial attention. Our results show that spatial and feature-based attention interacted: resampling of visual space depended on both the attended location and feature (color vs. temporal frequency). This interaction occurred similarly throughout visual cortex, regardless of an area's overall feature preference. However, the interaction did depend on spatial sampling properties of voxels that prefer the attended feature. These findings are parsimoniously explained by variations in the precision of an attentional gain field. Our results demonstrate that the deployment of spatial attention is tailored to the spatial sampling properties of units that are sensitive to the attended feature.
- Published
- 2018
- Full Text
- View/download PDF
5. Causative Role of Anoxic Environment in Bacterial Regulation of Human Intestinal Function
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Chengyao Wang, Andrea Cancino, Jasmine Baste, Daniel Marten, Advait Anil Joshi, Amreen Nasreen, and Abhinav Bhushan
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Modeling and Simulation ,General Biochemistry, Genetics and Molecular Biology - Abstract
Life on Earth depends on oxygen; human tissues require oxygen signaling, whereas many microorganisms, including bacteria, thrive in anoxic environments. Despite these differences, human tissues and bacteria coexist in close proximity to each other such as in the intestine. How oxygen governs intestinal-bacterial interactions remains poorly understood.To address to this gap, we created a dual-oxygen environment in a microfluidic device to study the role of oxygen in regulating the regulation of intestinal enzymes and proteins by gut bacteria. Two-layer microfluidic devices were designed using a fluid transport model and fabricated using soft lithography. An oxygen-sensitive material was integrated to determine the oxygen levels. The intestinal cells were cultured in the upper chamber of the device. The cells were differentiated, upon which bacterial strains, a facultative anaerobe,The microfluidic device successfully established a dual-oxygen environment. Of particular importance in our findings was that both strains significantly upregulated mucin proteins and modulated several intestinal transporters and transcription factors but only under the anoxic-oxic oxygen gradient, thus providing evidence of the role of oxygen on bacterial-epithelial signaling.Our work that integrates cell and molecular biology with bioengineering presents a novel strategy to engineer an accessible experimental system to provide tailored oxygenated environments. The work could provide new avenues to study intestine-microbiome signaling and intestinal tissue engineering, as well as a novel perspective on the indirect effects of gut bacteria on tissues including tumors.The online version contains supplementary material available at 10.1007/s12195-022-00735-x.
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- 2022
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6. Topographic Maps of Visual Space in the Human Cerebellum
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Wietske van der Zwaag, Tomas Knapen, Daniel Marten van Es, Spinoza Centre for Neuroimaging, Cognitive Psychology, and IBBA
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0301 basic medicine ,Adult ,Male ,Cerebellum ,Visual perception ,genetic structures ,cerebellum ,Visual space ,receptive field ,visual perception ,Biology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Neural Pathways ,medicine ,Humans ,retinotopy ,pRF ,Brain Mapping ,Human Connectome Project ,Working memory ,fMRI ,Sensory Systems ,Ophthalmology ,030104 developmental biology ,medicine.anatomical_structure ,Receptive field ,Cerebral cortex ,Retinotopy ,Female ,General Agricultural and Biological Sciences ,Neuroscience ,Cartography ,030217 neurology & neurosurgery ,Geology - Abstract
The purported role of the cerebellum has shifted from one that is exclusively sensorimotor related to one that encompasses a wide range of cognitive and associative functions [1–5]. Within sensorimotor areas of the cerebellum, functional organization is characterized by ipsilateral representations of the body [6]. Yet, in the remaining cerebellar cognitive and associative networks, functional organization remains less well understood. Regions of cerebral cortex [7–9] and subcortex [10] important for visual perception and cognition are organized topographically: neural organization mirrors the retina. Recently, it was shown that known retinotopic areas in cerebral cortex are functionally connected to nodes in the cerebellum [2, 11, 12]. In fact, this revealed signals with visuospatial selectivity in the cerebellum [13]. Here, we analyzed the highly powered Human Connectome Project (HCP) retinotopy dataset [14] to create a comprehensive and detailed overview of visuospatial organization in the cerebellum. This revealed 5 ipsilateral topographic maps in 3 cerebellar clusters (oculomotor vermis [OMV]-lobule VIIb-lobule VIIIb), of which we quantified visual field coverage and topography. These quantifications dovetail with the known roles of these areas in eye movements (OMV) [5, 15], attention (OMV-VIIb) [5, 13], working memory (VIIb) [13], and the integration of visuomotor information with respect to effector movements (VIIIb) [5]. To aid future research on visual perception in the cerebellum, we provide an online atlas of the visuospatial maps in Montreal Neurological Institute (MNI) space. Our findings demonstrate that the cerebellum is abundant with visuospatial information and, moreover, that it is organized according to known retinotopic properties. van Es et al. find the cerebellum's responses to visual stimuli to be retinotopically organized and highly similar to visual responses in the cerebral visual system. They publish an atlas of 5 visually selective regions in 3 cerebellar clusters.
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- 2019
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7. Author response: Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention
- Author
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Daniel Marten van Es, Jan Theeuwes, and Tomas Knapen
- Subjects
Visual cortex ,medicine.anatomical_structure ,Computer science ,business.industry ,Feature based ,medicine ,Sampling (statistics) ,Pattern recognition ,Artificial intelligence ,business - Published
- 2018
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8. Implicit and explicit learning in reactive and voluntary saccade adaptation
- Author
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van Es, Daniel Marten, Knapen, Tomas, van Es, Daniel Marten, and Knapen, Tomas
- Abstract
Saccades can either be elicited automatically by salient peripheral stimuli or can additionally depend on explicit cognitive goals. Similarly, it is thought that motor adaptation is driven by the combination of a more automatic, implicit process and a more explicit, cognitive process. However, the degree to which such implicit and explicit learning contribute to the adaptation of more reactive and voluntary saccades remains elusive. To study this question, we employed a global saccadic adaptation paradigm with both increasing and decreasing saccade amplitudes. We assessed the resulting adaptation using a dual state model of motor adaptation. This model decomposes learning into a fast and slow process, which are thought to constitute explicit and implicit learning, respectively. Our results show that adaptation of reactive saccades is equally driven by fast and slow learning, while fast learning is nearly absent when adapting voluntary (i.e. scanning) saccades. This pattern of results was present both when saccade gain was increased or decreased. Our results suggest that the increased cognitive demands associated with voluntary compared to reactive saccade planning interfere specifically with explicit learning.
- Published
- 2019
9. Estimation of Currents Flows and Future Needs of Investment for Low-Carbon Transition in Major Economies of Asia Until 2030
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Kevin Treco, Daniel Marten, and Chris Stephens
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Economy ,business.industry ,Climate change ,Investment (macroeconomics) ,business ,China ,Southeast asian ,Energy policy ,Hydropower ,Efficient energy use ,Renewable energy - Abstract
Significant contributions to global emissions by major Asian economies and their vulnerability to climate change impacts has contributed to a sense of urgency for leaders to implement policies and allocate investment into low-carbon energy systems. Current levels of investment are dominated by China and India, and while other Southeast Asian countries have lagged behind, along with India, their share is expected to increase. Energy efficiency investments are overshadowed by those into renewables, with wind, hydropower and solar representing the lion’s share of the mix. Looking ahead, while these technologies will continue to dominate, spending on solar and hydropower is expected to decline, and investment in energy efficiency is expected to increase faster than that in renewables. Future investments will have to increase 5% per year from 2015 to meet the required levels of annual spend in 2026–2030 predicted. This may prove challenging for smaller countries that do not have the same policy and technology capabilities. Individual countries vary in the technologies they plan to invest in throughout the 2017–2030 period. Solar and energy efficiency will be opportunities in most countries, as will biomass, with the exception of India. Wind will mainly be an opportunity in China, India and Vietnam. Hydropower opportunities will be focused in China, India, Indonesia and Vietnam and geothermal opportunities will almost exclusively exist in Indonesia and the Philippines.
- Published
- 2018
- Full Text
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10. Interregional alpha-band synchrony supports temporal cross-modal integration
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Tomas Knapen, Michael X Cohen, Daniel Marten van Es, Joram van Driel, Cognitive Psychology, IBBA, and Brein en Cognitie (Psychologie, FMG)
- Subjects
Adult ,Male ,Time Factors ,genetic structures ,Adolescent ,Cognitive Neuroscience ,Time perception ,Sensory system ,Stimulus (physiology) ,Electroencephalography ,Bayesian inference ,Developmental psychology ,Cross-modal integration ,Young Adult ,Functional connectivity ,Psychometric function ,Stimulus modality ,medicine ,Psychophysics ,Alpha-band ,Humans ,Attention ,Brain Mapping ,Modalities ,medicine.diagnostic_test ,Phase synchrony ,Bayes Theorem ,Alpha Rhythm ,Neurology ,Auditory Perception ,Visual Perception ,Female ,Sensorimotor Cortex ,Psychology ,Psychomotor Performance ,Cognitive psychology - Abstract
In a continuously changing environment, time is a key property that tells us whether information from the different senses belongs together. Yet, little is known about how the brain integrates temporal information across sensory modalities. Using high-density EEG combined with a novel psychometric timing task in which human subjects evaluated durations of audiovisual stimuli, we show that the strength of alpha-band (8-12. Hz) phase synchrony between localizer-defined auditory and visual regions depended on cross-modal attention: during encoding of a constant 500. ms standard interval, audiovisual alpha synchrony decreased when subjects attended audition while ignoring vision, compared to when they attended both modalities. In addition, alpha connectivity during a variable target interval predicted the degree to which auditory stimulus duration biased time estimation while attending vision. This cross-modal interference effect was estimated using a hierarchical Bayesian model of a psychometric function that also provided an estimate of each individual's tendency to exhibit attention lapses. This lapse rate, in turn, was predicted by single-trial estimates of the stability of interregional alpha synchrony: when attending to both modalities, trials with greater stability in patterns of connectivity were characterized by reduced contamination by lapses. Together, these results provide new insights into a functional role of the coupling of alpha phase dynamics between sensory cortices in integrating cross-modal information over time. © 2014 Elsevier Inc.
- Published
- 2014
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11. Implicit and explicit learning in reactive and voluntary saccade adaptation
- Author
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van Es, Daniel Marten, primary and Knapen, Tomas, additional
- Published
- 2019
- Full Text
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12. Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention
- Author
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van Es, Daniel Marten, primary, Theeuwes, Jan, additional, and Knapen, Tomas, additional
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- 2018
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- View/download PDF
13. Author response: Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention
- Author
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van Es, Daniel Marten, primary, Theeuwes, Jan, additional, and Knapen, Tomas, additional
- Published
- 2018
- Full Text
- View/download PDF
14. Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention
- Author
-
van Es, Daniel Marten, Theeuwes, Jan, Knapen, Tomas, van Es, Daniel Marten, Theeuwes, Jan, and Knapen, Tomas
- Abstract
Spatial attention changes the sampling of visual space. Behavioral studies suggest that feature-based attention modulates this resampling to optimize the attended feature's sampling. We investigate this hypothesis by estimating spatial sampling in visual cortex while independently varying both feature-based and spatial attention. Our results show that spatial and feature-based attention interacted: resampling of visual space depended on both the attended location and feature (color vs. temporal frequency). This interaction occurred similarly throughout visual cortex, regardless of an area's overall feature preference. However, the interaction did depend on spatial sampling properties of voxels that prefer the attended feature. These findings are parsimoniously explained by variations in the precision of an attentional gain field. Our results demonstrate that the deployment of spatial attention is tailored to the spatial sampling properties of units that are sensitive to the attended feature.
- Published
- 2018
15. Visual cortex activity predicts subjective experience after reading books with colored letters
- Author
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Olympia Colizoli, Jaap M. J. Murre, Tomas Knapen, Romke Rouw, H. Steven Scholte, Daniel Marten van Es, Cognitive Psychology, IBBA, and Brein en Cognitie (Psychologie, FMG)
- Subjects
Adult ,Male ,genetic structures ,Cognitive Neuroscience ,media_common.quotation_subject ,Experimental and Cognitive Psychology ,050105 experimental psychology ,Young Adult ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Visual memory ,medicine ,Humans ,Contrast (vision) ,0501 psychology and cognitive sciences ,Synesthesia ,Visual Cortex ,media_common ,Color psychology ,Brain Mapping ,medicine.diagnostic_test ,05 social sciences ,Brain ,medicine.disease ,Magnetic Resonance Imaging ,Visual cortex ,medicine.anatomical_structure ,Pattern Recognition, Visual ,Reading ,Stroop Test ,Female ,Psychology ,Functional magnetic resonance imaging ,SDG 4 - Quality Education ,Color Perception ,Photic Stimulation ,030217 neurology & neurosurgery ,Mental image ,Stroop effect ,Cognitive psychology - Abstract
One of the most astonishing properties of synesthesia is that the evoked concurrent experiences are perceptual. Is it possible to acquire similar effects after learning cross-modal associations that resemble synesthetic mappings? In this study, we examine whether brain activation in early visual areas can be directly related to letter-color associations acquired by training. Non-synesthetes read specially prepared books with colored letters for several weeks and were scanned using functional magnetic resonance imaging. If the acquired letter-color associations were visual in nature, then brain activation in visual cortex while viewing the trained black letters (compared to untrained black letters) should predict the strength of the associations, the quality of the color experience, or the vividness of visual mental imagery. Results showed that training-related activation of area V4 was correlated with differences in reported subjective color experience. Trainees who were classified as having stronger 'associator' types of color experiences also had more negative activation for trained compared to untrained achromatic letters in area V4. In contrast, the strength of the acquired associations (measured as the Stroop effect) was not reliably reflected in visual cortex activity. The reported vividness of visual mental imagery was related to veridical color activation in early visual cortex, but not to the acquired color associations. We show for the first time that subjective experience related to a synesthesia-training paradigm was reflected in visual brain activation.
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- 2016
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16. Adjustable bulbourethral male sling: Experience after 30 cases of moderate to severe male stress urinary incontinence
- Author
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Michele Cotugno, Daniel Martens, Giacomo Pirola, Martina Maggi, Carmelo Destro Pastizzaro, Michele Potenzoni, Bernardo Cesare Maria Rocco, Salvatore Micali, and Andrea Prati
- Subjects
Sling ,Prostatectomy ,Male stress urinary incontinence ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: To report our experience using the Argus perineal sling from July 2015 to April 2018 for male stress urinary incontinence (SUI) after prostatic surgery. To evaluate the safety, efficacy and healthrelated quality of life in patients undergoing this procedure. Patients and methods: The positioning of an adjustable bulbourethral male sling provides a perineal incision, exposure of the bulbospongiosus muscle and the application of the sling bearing on it with transobturator passage of the two extremities with out-in technique. To modulate the bearing tension on the urethra, with a rigid cystoscope the Retrogade Leak Point Pressure is measured, increasing it by 10-15 cm of H20 from baseline. We retrospectively evaluated the results of this implant performed by the same operator on 30 patients who presented post-operative SUI from medium to severe (> = 2 pads/day, pad test at one hour > = 11 g). Mean operative time and possible intra and postoperative complications were evaluated. Postoperatively each patient was reassessed according to the following parameters: number of pads consumed/ die, pad tesy at one hour, ICQS-F, any related side effects. Results: After the intervention, 21 of 30 patients (70% of the total) were totally continent (< 1 pad / day, pad test at 1 h < 1-2 g, ICQS-F < 11), out of them 4 required a single adjustment at 3 months in order to achieve this result. 9 of 30 patients (30 %) achieved a clinically significant improvement without obtaining total continence (mean reduction of the n° pads/day: -2.5 ± 1 DS; average reduction of the pad test at 1 h: -20 g ± 4 DS; ICQS-F average reduction: -6 points ± 2 DS), out of them 5 required a 3 month adjustment to obtain these improvements resulting, 4 needed 2 adjustments resulting because the first adjustment was not satisfactory and one who ameliorated from severe to moderate incontinence decided to live in this clinical condition. Conclusions: The results of our study show that the positioning of this sling represents a valid treatment for the moderate and severe post-surgical male SUI. The possibility of adjusting the tension of the sleeve in a "second look" makes the intervention adaptable according to the results obtained. Only multicentric clinical trials on larger series would clarify and eventually confirm the clinical benefits of this sling in post-surgical male SUI.
- Published
- 2020
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17. Right open nephrectomy under combined spinal and peridural operative anesthesia and analgesia (CSE): A new anesthetic approach in abdominal surgery
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Michele Cotugno, Matteo Dallaglio, Luca Cantadori, Fabio Villani, Daniel Martens, Federico Cantoni, Michele Potenzoni, Salvatore Micali, M.C. Bernardo Rocco, and Andrea Prati
- Subjects
Nephrectomy ,Spinal ,Epidural ,Anesthesia ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
A case of right open nephrectomy performed under combined spinal and epidural anesthesia and analgesia was presented. This new anesthetic technique gives significant advantages to the patient by avoiding endotracheal intubation with mechanical ventilation and curare administration and by reducing the use of opioids.
- Published
- 2020
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18. Photochemical spacecraft self-contamination - Laboratory results andsystems impacts
- Author
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Thomas B. Stewart, Graham S. Arnold, David F. Hall, Dean C. Marvin, Warren C. Hwang, Rolaine C. Young Owl, and H. Daniel Marten
- Subjects
Materials science ,Adsorption ,Accretion (meteorology) ,Space and Planetary Science ,Desorption ,Photodissociation ,Condensation ,Kinetics ,Aerospace Engineering ,Deposition (phase transition) ,Contamination ,Photochemistry - Abstract
It has become clear that photochemical reactions induced by solar vacuum ultraviolet (VUV) radiation play a substantial role in contaminant accretion and effects. A series of laboratory measurements of the absolute rates of adsorption, desorption, and VUV-induced deposition of contaminants have been made under simulated spacecraft conditions. The results of these experiments, together with analyses of operational and experimental flight data, show conclusively that the role of sunlight is not merely to darken or fix previously condensed contaminant films, but also to promote the irreversible deposition of contaminant films under conditions in which condensation would not occur. A simple model of the kinetics of photochemical deposition, based on a competition between desorption and photolysis of a transiently adsorbed contaminant molecule, using experimentally measured parameters, is reasonably successful in describing the deposition process. These laboratory experiments and analyses of space-flight experience reveal that photochemical deposition is significant mechanism whereby contaminant films accrete on orbit and must be considered in the design of future vehicles.
- Published
- 1989
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19. Cerebral MRI and EEG studies in the initial management of pediatric headaches
- Author
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Daniel Martens, Isabel Oster, Sven Gottschlling, Panagiotis Papanagiotou, Karin Ziegler, Regina Eymann, Mei-Fang Ong, Ludwig Gortner, and Sascha Meyer
- Subjects
children ,electroencephalogram (EEG) ,heachache ,magnet resonance imaging (MRI) ,Medicine - Abstract
BACKGROUND AND STUDY PURPOSE: High resolution imaging modalities and electroencephalographic studies (EEG) are used in the assessment of children with headaches. We evaluated the role of cerebral MRI (cMRI) and EEG in the initial assessment of children with headache as the chief complaint of initial presentation. METHODS: A retrospective chart analysis was performed at a tertiary University Hospital. RESULTS: 209 patients were included in this study [mean age 11.3 years; male 91 (43.5%); female 118 (56.5%)]. The following types of headaches were seen: Unclassified headache: 23.4%; probable migraine 17.2%, migraine without aura 13.4%, complicated migraine 12.4%, migraine with aura 1.0%; tension-type 15.3%, and cluster headaches 0.5%, and secondary headaches 16.7%. In 93 children (44.5%) abnormal physical/neurological findings were noted (multiple entries possible). On cMRI studies the following findings were seen: Infection of sinuses (7.2%), pineal cysts (2.4%), arachnoidial cyst and Chiari malformation (1.9%), unspecified signal enhancement (1.0%), and pituitary enlargement, inflammatory lesion, angioma, cerebral ischaemia, and intra-cerebral cyst (each 0.5%). Electroencephalographic findings included both focal and generalised abnormal slowing (5.3%) and Spike-wave complexes (3.3%). CONCLUSIONS: Despite abnormal findings on neurological/physical examination in a substantial number of children with headaches, the yield of pathological cMRIs was low. The use of EEG recordings was not contributory to the diagnostic and therapeutic approach. More research is needed to better define those patients who are likely to have an intracranial pathology.
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- 2012
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20. Integration of spintronic interface for nanomagnetic arrays
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Andrew Lyle, Jonathan Harms, Todd Klein, August Lentsch, Angeline Klemm, Daniel Martens, and Jian-Ping Wang
- Subjects
Physics ,QC1-999 - Abstract
An experimental demonstration utilizing a spintronic input/output (I/O) interface for arrays of closely spaced nanomagnets is presented. The free layers of magnetic tunnel junctions (MTJs) form dipole coupled nanomagnet arrays which can be applied to different contexts including Magnetic Quantum Cellular Automata (MQCA) for logic applications and self-biased devices for field sensing applications. Dipole coupled nanomagnet arrays demonstrate adaptability to a variety of contexts due to the ability for tuning of magnetic response. Spintronics allows individual nanomagnets to be manipulated with spin transfer torque and monitored with magnetoresistance. This facilitates measurement of the magnetic coupling which is important for (yet to be demonstrated) data propagation reliability studies. In addition, the same magnetic coupling can be tuned to reduce coercivity for field sensing. Dipole coupled nanomagnet arrays have the potential to be thousands of times more energy efficient than CMOS technology for logic applications, and they also have the potential to form multi-axis field sensors.
- Published
- 2011
- Full Text
- View/download PDF
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