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106 results on '"Daniel Jiménez-González"'

1. Transmitancia térmica de la envolvente y cumplimiento del DB-HE 2019 para un bloque de viviendas

Author

Jesús Sobaler-Rodríguez, Rafael Villar-Burke, Marta Sorribes-Gil, and Daniel Jiménez-González

Subjects
aislamiento, envolvente, eficiencia energética, fachada, optimización, Architecture, NA1-9428, Building construction, TH1-9745
Abstract

Este artículo analiza el cumplimiento normativo de las secciones HE0 y HE1 del reciente DB-HE 2019 y el coste económico de la envolvente térmica para un edificio de uso residencial plurifamiliar entre medianerías. Se ha estudiado este modelo con distintos porcentajes de huecos y se han examinado las soluciones necesarias para los diferentes climas de la geografía española, con el objetivo de encontrar estrategias para la verificación de los requisitos de control de la demanda y límite de los consumos incorporados en la última actualización del DB-HE, a través de criterios de optimización económica en base a un modelo de costes simplificado.

Published
2022
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2. A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels

Author

Alejandro Valdés-Jiménez, Daniel Jiménez-González, Aytug K. Kiper, Susanne Rinné, Niels Decher, Wendy González, Miguel Reyes-Parada, and Gabriel Núñez-Vivanco

Subjects
polypharmacology, binding site similarity, cardiac ion channels, tafluprost, binding site comparisons, Therapeutics. Pharmacology, RM1-950
Abstract

The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. Also, it would be a reasonable first step for the design of novel multitarget compounds. Most of the current computational tools employed for this aim are limited to the comparisons among known binding sites, and do not consider several additional important 3D patterns such as allosteric sites or other conserved motifs. In the present work, we introduce Geomfinder2.0, which is a new and improved version of our previously described algorithm for the deep exploration and discovery of similar and druggable 3D patterns. As compared with the original version, substantial improvements that have been incorporated to our software allow: (i) to compare quaternary structures, (ii) to deal with a list of pairs of structures, (iii) to know how druggable is the zone where similar 3D patterns are detected and (iv) to significantly reduce the execution time. Thus, the new algorithm achieves up to 353x speedup as compared to the previous sequential version, allowing the exploration of a significant number of quaternary structures in a reasonable time. In order to illustrate the potential of the updated Geomfinder version, we show a case of use in which similar 3D patterns were detected in the cardiac ions channels NaV1.5 and TASK-1. These channels are quite different in terms of structure, sequence and function and both have been regarded as important targets for drugs aimed at treating atrial fibrillation. Finally, we describe the in vitro effects of tafluprost (a drug currently used to treat glaucoma, which was identified as a novel putative ligand of NaV1.5 and TASK-1) upon both ion channels’ activity and discuss its possible repositioning as a novel antiarrhythmic drug.

Published
2022
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3. Autoimmune pancreatitis diagnosis based on immunoglobulin G4 levels: Case report

Author

Lina Acosta-Buitrago, Akram Kadamani, Daniel Jiménez-González, Paulo Cabrera, and Carlos Pérez-Rivera

Subjects
Autoimmune Pancreatitis, Diagnosis, Immunoglobulins, Medicine, Medicine (General), R5-920
Abstract

Introduction: Autoimmune pancreatitis is a rare form of chronic pancreatitis, with an estimated prevalence of 1 case per 100 000 inhabitants in the general population. It is characterized by the presence of painless obstructive jaundice and imaging findings of a diffusely enlarged pancreas and loss of its lobularity. Depending on its features, it can be classified as subtype 1 or 2, and its diagnosis is reached based on imaging, serological, and histological findings, as well as the patient’s response to corticosteroid therapy, which in turn is the indicated treatment for this disease. Case presentation: A 62-year-old man was admitted to the emergency department of a quaternary care hospital in Bogotá D.C. due to generalized jaundice associated with choluria and acholia. Upon admission, the patient was assessed by the general surgery and gastroenterology services and diagnosed with autoimmune pancreatitis based on immunoglobulin G4 levels and imaging and laboratory findings compatible with this disease. He was successfully treated with corticosteroids, obtaining satisfactory clinical outcomes and a complete resolution of symptoms. Conclusions: Autoimmune pancreatitis is a disease that should be suspected in patients with symptoms of painless obstructive jaundice, thus avoiding misdiagnoses and providing timely treatment that allows the resolution of symptoms and proper management of the disease.

Published
2021
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4. The TEXTAROSSA Project: Cool all the Way Down to the Hardware.

Author

Antonio Filgueras, Giovanni Agosta, Marco Aldinucci, Carlos álvarez 0001, Pasqua D'Ambra, Massimo Bernaschi, Andrea Biagioni, Daniele Cattaneo 0002, Alessandro Celestini, Massimo Celino, Carlotta Chiarini, Francesca Lo Cicero, Paolo Cretaro, William Fornaciari, Ottorino Frezza, Andrea Galimberti, Francesco Giacomini, Juan Miguel De Haro Ruiz, Francesco Iannone, Daniel Jaschke, Daniel Jiménez-González, Michal Kulczewski, Alberto Leva, Alessandro Lonardo, Michele Martinelli, Xavier Martorell, Simone Montangero, Lucas Morais, Ariel Oleksiak, Paolo Palazzari, Luca Pontisso, Federico Reghenzani, Cristian Rossi, Sergio Saponara, Carlo Saverio Lodi, Francesco Simula, Federico Terraneo, Piero Vicini, Miquel Vidal, Davide Zoni, and Giuseppe Zummo

Published
2024
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15. The AXIOM Project: IoT on Heterogeneous Embedded Platforms.

Author

Antonio Filgueras, Miquel Vidal, Marc Mateu, Daniel Jiménez-González, Carlos álvarez 0001, Xavier Martorell, Eduard Ayguadé, Dimitrios Theodoropoulos, Dionisios N. Pnevmatikatos, Paolo Gai, Stefano Garzarella, David Oro, Javier Hernando, Nicola Bettin, Alberto Pomella, Marco Procaccini, and Roberto Giorgi

Published
2021
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17. LEGaTO: first steps towards energy-efficient toolset for heterogeneous computing.

Author

Adrián Cristal, Osman S. Unsal, Xavier Martorell, Paul Carpenter, Raúl de la Cruz, Leonardo Bautista-Gomez, Daniel Jiménez-González, Carlos álvarez 0001, Behzad Salami 0001, Sergi Madonar, Miquel Pericàs, Pedro Trancoso, Micha vor dem Berge, Gunnar Billung-Meyer, Stefan Krupop, Wolfgang Christmann, Frank Klawonn, Amani Mihklafi, Tobias Becker, Georgi Gaydadjiev, Hans Salomonsson, Devdatt P. Dubhashi, Oron Port, Elad Hadar, Yoav Etsion, Christof Fetzer, Jens Hagemeyer, Thorsten Jungeblut, Nils Kucza, Martin Kaiser, Mario Porrmann, Marcelo Pasin, Valerio Schiavoni, Isabelly Rocha, Christian Göttel, and Pascal Felber

Published
2018
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24. LEGaTO: towards energy-efficient, secure, fault-tolerant toolset for heterogeneous computing.

Author

Adrián Cristal, Osman S. Unsal, Xavier Martorell, Paul Carpenter, Raúl de la Cruz, Leonardo Bautista-Gomez, Daniel Jiménez-González, Carlos álvarez 0001, Behzad Salami 0001, Sergi Madonar, Miquel Pericàs, Pedro Trancoso, Micha vor dem Berge, Gunnar Billung-Meyer, Stefan Krupop, Wolfgang Christmann, Frank Klawonn, Amani Mihklafi, Tobias Becker, Georgi Gaydadjiev, Hans Salomonsson, Devdatt P. Dubhashi, Oron Port, Yoav Etsion, Vesna Nowack, Christof Fetzer, Jens Hagemeyer, Thorsten Jungeblut, Nils Kucza, Martin Kaiser, Mario Porrmann, Marcelo Pasin, Valerio Schiavoni, Isabelly Rocha, Christian Göttel, and Pascal Felber

Published
2018
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30. AXIOM: A Hardware-Software Platform for Cyber Physical Systems.

Author

Somnath Mazumdar, Eduard Ayguadé, Nicola Bettin, Javier Bueno, Sara Ermini, Antonio Filgueras, Daniel Jiménez-González, Carlos álvarez-Martínez, Xavier Martorell, Francesco Montefoschi, David Oro, Dionisios N. Pnevmatikatos, Antonio Rizzo, Dimitris Theodoropoulos, and Roberto Giorgi

Published
2016
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33. The AXIOM platform for next-generation cyber physical systems.

Author

Dimitris Theodoropoulos, Somnath Mazumdar, Eduard Ayguadé, Nicola Bettin, Javier Bueno, Sara Ermini, Antonio Filgueras, Daniel Jiménez-González, Carlos álvarez-Martínez, Xavier Martorell, Francesco Montefoschi, David Oro, Dionisis N. Pnevmatikatos, Antonio Rizzo, Paolo Gai, Stefano Garzarella, Bruno Morelli, Alberto Pomella, and Roberto Giorgi

Published
2017
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34. The AXIOM project (Agile, eXtensible, fast I/O Module).

Author

Dimitris Theodoropoulos, Dionisios N. Pnevmatikatos, Carlos álvarez 0001, Eduard Ayguadé, Javier Bueno, Antonio Filgueras, Daniel Jiménez-González, Xavier Martorell, Nacho Navarro, Carlos Segura, Carles Fernández, David Oro, Javier Rodríguez Saeta, Paolo Gai, Antonio Rizzo, and Roberto Giorgi

Published
2015
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37. The AXIOM Software Layers.

Author

Carlos álvarez 0001, Eduard Ayguadé, Javier Bueno, Antonio Filgueras, Daniel Jiménez-González, Xavier Martorell, Nacho Navarro, Dimitris Theodoropoulos, Dionisios N. Pnevmatikatos, Davide Catani, Claudio Scordino, Paolo Gai, Carlos Segura, Carles Fernández, David Oro, Javier Rodríguez Saeta, Pierluigi Passera, Alberto Pomella, Antonio Rizzo, and Roberto Giorgi

Published
2015
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39. The AXIOM software layers.

Author

Carlos álvarez 0001, Eduard Ayguadé, Jaume Bosch, Javier Bueno, Artem Cherkashin, Antonio Filgueras, Daniel Jiménez-González, Xavier Martorell, Nacho Navarro, Miquel Vidal, Dimitris Theodoropoulos, Dionisios N. Pnevmatikatos, Davide Catani, David Oro, Carles Fernández, Carlos Segura, Javier Rodríguez Saeta, Javier Hernando, Claudio Scordino, Paolo Gai, and Pierluigi Passera

Published
2016
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