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Purpose Despite numerous mentoring strategies to promote academic success and eligibility in medicine, Black students remain disproportionately underrepresented in medicine. Therefore, we conducted a scoping review to identify the mentoring practices available to Black pre-medical students, medical students and medical residents, specifically the mentoring strategies used, their application, and their evaluation. Method Between May 2023 and October 2023, the authors conducted a literature review. Studies that described a mentoring strategy applied among Black learners were eligible for inclusion, and all years of publication were included. Two reviewers screened each article using the Covidence tool, and conflicts were resolved by a third author. All reviewers extracted the data to summarize the various mentoring practices. Results After screening 6292 articles, 42 articles met the criteria for full review. Of these, 14 studies were included in the study. Mentoring practices for Black students included peer mentoring, dyad mentoring, and group mentoring. Mentoring was typically offered through discussion groups, educational internships, and didactic activities. Evaluation of mentoring programs took into account (1) pass rates on medical exams (eg, MCAT, Casper), (2) receipt of an invitation to a medical school admissions interview, (3) successful match to a competitive residency program, and (4) a mentee's report of the overall experience and effectiveness of the program. Conclusion This review is the first, to our knowledge, to focus on mentoring strategies implemented among Black learners in medicine. The results will inform mentoring strategies adapted for Black learners and will therefore address the underrepresentation of Black students in medicine.

The nature of the global signal, i.e. the average signal from sequential functional imaging scans of the brain or the cortex, is not well understood, but is thought to include vascular and neural components. Using resting state data, we report on the strong association between the global signal and the average signal from the part of the volume that includes the cranial bone and subdural vessels and venous collectors, separated from each other and the subdural space by multispectral segmentation procedures. While subdural vessels carried a signal with a phase delay relative to the cortex, the association with the cortical signal was strongest in the parts of the scan corresponding to the laminae of the cranial bone, reaching 80% shared variance in some individuals. These findings suggest that in resting state data vascular components may play a prominent role in the genesis of fluctuations of the global signal. Evidence from other studies on the existence of neural sources of the global signal suggests that it may reflect the action of multiple mechanisms (including cerebrovascular reactivity and autonomic control) concurrently acting to regulate global cerebral perfusion.

The orbits of close-in exoplanets provide clues to their formation and evolutionary history. Many close-in exoplanets likely formed far out in their protoplanetary disks and migrated to their current orbits, perhaps via high-eccentricity migration (HEM), a process that can also excite obliquities. A handful of known exoplanets are perhaps caught in the act of HEM, as they are observed on highly eccentric orbits with tidal circularization timescales shorter than their ages. One such exoplanet is Kepler-1656 b, which is also the only known nongiant exoplanet ( 0.8 to have its obliquity constrained; expanding this population will help establish the degree to which orbital misalignment accompanies migration. Future work that constrains the mutual inclinations of outer perturbers will be key for distinguishing plausible mechanisms.

Background: Current protein biomarkers are only moderately predictive at identifying individuals with mild traumatic brain injury or concussion. Therefore, more accurate diagnostic markers are needed for sport-related concussion. Methods: This was a multicenter, prospective, case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the National Collegiate Athletic Association–Department of Defense Concussion Assessment, Research, and Education Consortium conducted between 2015 and 2019. The blood was collected within 48 h of injury to identify protein abnormalities at the acute and subacute timepoints. Athletes with concussion were divided into 6 h post-injury (0–6 h post-injury) and after 6 h post-injury (7–48 h post-injury) groups. We applied a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1305 proteins in plasma samples from athletes with and without sport-related concussion. Results: A total of 140 athletes with concussion (79.3% males; aged 18.71 ± 1.10 years, mean ± SD) and 21 non-concussed athletes (76.2% males; 19.14 ± 1.10 years) were included in this study. We identified 338 plasma proteins that significantly differed in abundance (319 upregulated and 19 downregulated) in concussed athletes compared to non-concussed athletes. The top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve (AUC) of 0.954 (95% confidence interval: 0.922‒0.986). Specifically, after 6 h of injury, the individual AUC of plasma erythrocyte membrane protein band 4.1 (EPB41) and alpha-synuclein (SNCA) were 0.956 and 0.875, respectively. The combination of EPB41 and SNCA provided the best AUC (1.000), which suggests this combination of candidate plasma biomarkers is the best for diagnosing concussion in athletes after 6 h of injury. Conclusion: Our data suggest that proteomic profiling may provide novel diagnostic protein markers and that a combination of EPB41 and SNCA is the most predictive biomarker of concussion after 6 h of injury.

ObjectiveThe aim of this study was to investigate phosphorylated tau (p-tau181) protein in plasma in a cohort of mild traumatic brain injury (mTBI) patients and a cohort of concussed athletes.MethodsThis pilot study comprised two independent cohorts. The first cohort—part of a Traumatic Head Injury Neuroimaging Classification (THINC) study—with a mean age of 46 years was composed of uninjured controls (UIC, n = 30) and mTBI patients (n = 288) recruited from the emergency department with clinical computed tomography (CT) and research magnetic resonance imaging (MRI) findings. The second cohort—with a mean age of 19 years—comprised 133 collegiate athletes with (n = 112) and without (n = 21) concussions. The participants enrolled in the second cohort were a part of a multicenter, prospective, case-control study conducted by the NCAA-DoD Concussion Assessment, Research and Education (CARE) Consortium at six CARE Advanced Research Core (ARC) sites between 2015 and 2019. Blood was collected within 48 h of injury for both cohorts. Plasma concentration (pg/ml) of p-tau181 was measured using the Single Molecule Array ultrasensitive assay.ResultsConcentrations of plasma p-tau181 in both cohorts were significantly elevated compared to controls within 48 h of injury, with the highest concentrations of p-tau181 within 18 h of injury, with an area under the curve (AUC) of 0.690–0.748, respectively, in distinguishing mTBI patients and concussed athletes from controls. Among the mTBI patients, the levels of plasma p-tau181 were significantly higher in patients with positive neuroimaging (either CT+/MRI+, n = 74 or CT−/MRI+, n = 89) compared to mTBI patients with negative neuroimaging (CT−/MRI−, n = 111) findings and UIC (P-values < 0.05).ConclusionThese findings indicate that plasma p-tau181 concentrations likely relate to brain injury, with the highest levels in patients with neuroimaging evidence of injury. Future research is needed to replicate and validate this protein assay's performance as a possible early diagnostic biomarker for mTBI/concussions.

Characterizing outer companions to hot Jupiters plays a crucial role in deciphering their origins. We present the discovery of a long-period giant planet, HD 118203 c ( ${m}_{c}={11.79}_{-0.63}^{+0.69}\ {M}_{{\rm{J}}}$ , ${a}_{c}={6.28}_{-0.11}^{+0.10}$ au) exterior to a close-in eccentric hot Jupiter HD 118203 b ( P _b = 6.135 days, m _b = 2.14 ± 0.12 M _J , r _b = 1.14 ± 0.029 R _J , e _b = 0.31 ± 0.007) based on 20 yr radial velocities (RVs). Using Rossiter–McLaughlin (RM) observations from the Keck Planet Finder, we measured a low sky-projected spin–orbit angle ${\lambda }_{b}=-11^\circ {7}_{-10.0}^{+7.6}$ for HD 118203 b and detected stellar oscillations in the host star, confirming its evolved status. Combining the RM observation with the stellar inclination measurement, we constrained the true spin–orbit angle of HD 118203 b as Ψ _b < 33.°5 (2 σ ), indicating the orbit normal of the hot Jupiter nearly aligned with the stellar spin axis. Furthermore, by combining RVs and Hipparcos-Gaia astrometric acceleration, we constrained the line-of-sight mutual inclination between the hot Jupiter and the outer planet to be $9\buildrel{\circ}\over{.} {8}_{-9.3}^{+16.2}$ at the 2 σ level. HD 118203 is one of first hot Jupiter systems where both the true spin–orbit angle of the hot Jupiter and the mutual inclination between inner and outer planets have been determined. Our results are consistent with a system-wide alignment, with low mutual inclinations between the outer giant planet, the inner hot Jupiter, and the host star. This alignment, along with the moderate eccentricity of HD 118203 c, implies that the system may have undergone coplanar high-eccentricity tidal migration. Under this framework, our dynamical analysis suggests an initial semimajor axis of 0.3–3.2 au for the proto–hot Jupiter.

Planets and the stars they orbit are born from the same cloud of gas and dust, and the primordial compositions of rocky exoplanets have been assumed to have iron and refractory abundance ratios consistent with their host star. To test this assumption, we modeled the interior iron-to-rock ratio of 20 super-Earth-sized (1–1.8 R _⊕ ) exoplanets around stars with homogeneously measured stellar parameters. We computed the core mass fraction (CMF) for each planet and an equivalent “core mass fraction” for each host star based on its Fe and Mg abundances. We then fit a linear correlation using two methods (ordinary least squares and orthogonal distance regression) between planetary and stellar CMF, obtaining substantially different slopes between these two methods ( m = 1.3 ± 1.0 and m = 5.6 ± 1.6, respectively). Additionally, we find that 75% of planets have a CMF consistent with their host star to within 1 σ , and do not identify a distinct population of high-density super-Mercuries. Overall, we conclude that current uncertainties in observational data and differences in modeling methods prevent definitive conclusions about the relationship between planet and host-star chemical compositions.

Asteroseismology of dwarf stars cooler than the Sun is very challenging owing to the low amplitudes and rapid timescales of oscillations. Here we present the asteroseismic detection of solar-like oscillations at 4-minute timescales ( ${\nu }_{\max }\sim 4300$ μ Hz) in the nearby K dwarf σ Draconis using extreme-precision Doppler velocity observations from the Keck Planet Finder and 20 s cadence photometry from NASA’s Transiting Exoplanet Survey Satellite. The star is the coolest dwarf star to date with both velocity and luminosity observations of solar-like oscillations, having amplitudes of 5.9 ± 0.8 cm s ^−1 and 0.8 ± 0.2 ppm, respectively. These measured values are in excellent agreement with established luminosity−velocity amplitude relations for oscillations and provide further evidence that mode amplitudes for stars with T _eff < 5500 K diminish in scale following an ( L / M ) ^1.5 relation. By modeling the star’s oscillation frequencies from photometric data, we measure an asteroseismic age of 4.5 ± 0.9 (ran) ± 1.2 (sys) Gyr. The observations demonstrate the capability of next-generation spectrographs and precise space-based photometry to extend observational asteroseismology to nearby cool dwarfs, which are benchmarks for stellar astrophysics and prime targets for directly imaging planets using future space-based telescopes.

Very-metal-poor stars ([Fe/H] < −2) are important laboratories for testing stellar models and reconstructing the formation history of our galaxy. Asteroseismology is a powerful tool to probe stellar interiors and measure ages, but few asteroseismic detections are known in very-metal-poor stars and none have allowed detailed modeling of oscillation frequencies. We report the discovery of a low-luminosity Kepler red giant (KIC 8144907) with high signal-to-noise ratio oscillations, [Fe/H] = −2.66 ± 0.08 and [ α /Fe] = 0.38 ± 0.06, making it by far the most metal-poor star to date for which detailed asteroseismic modeling is possible. By combining the oscillation spectrum from Kepler with high-resolution spectroscopy, we measure an asteroseismic mass and age of 0.79 ± 0.02(ran) ± 0.01(sys) M _⊙ and 12.0 ± 0.6(ran) ± 0.4(sys) Gyr, with remarkable agreement across different codes and input physics, demonstrating that stellar models and asteroseismology are reliable for very-metal-poor stars when individual frequencies are used. The results also provide a direct age anchor for the early formation of the Milky Way, implying that substantial star formation did not commence until redshift z ≈ 3 (if the star formed in situ) or that the Milky Way has undergone merger events for at least ≈12 Gyr (if the star was accreted by a dwarf satellite merger such as Gaia-Enceladus).

Asteroseismic modeling is a powerful way to derive stellar properties. However, the derived quantities are limited by built-in assumptions used in stellar models. This work presents a detailed characterization of stellar model uncertainties in asteroseismic red giants, focusing on the mixing-length parameter α _MLT , the initial helium fraction Y _init , the solar abundance scale, and the overshoot parameters. First, we estimate error floors due to model uncertainties to be ≈0.4% in mass, ≈0.2% in radius, and ≈17% in age, primarily due to the uncertain state of α _MLT and Y _init . The systematic uncertainties in age exceed typical statistical uncertainties, suggesting the importance of their evaluation in asteroseismic applications. Second, we demonstrate that the uncertainties from α _MLT can be entirely mitigated by direct radius measurements or partially through ${\nu }_{\max }$ . Utilizing radii from Kepler eclipsing binaries, we determined the α _MLT values and calibrated the α _MLT –[M/H] relation. The correlation observed between the two variables is positive, consistent with previous studies using 1D stellar models, but in contrast with outcomes from 3D simulations. Third, we explore the implications of using asteroseismic modeling to test the ${\nu }_{\max }$ scaling relation. We found that a perceived dependency of ${\nu }_{\max }$ on [M/H] from individual frequency modeling can be largely removed by incorporating the calibrated α _MLT –[M/H] relation. Variations in Y _init can also affect ${\nu }_{\max }$ predictions. These findings suggest that ${\nu }_{\max }$ conveys information not fully captured by individual frequencies, and that it should be carefully considered as an important observable for asteroseismic modeling.

The solar-type subgiant β Hyi has long been studied as an old analog of the Sun. Although the rotation period has never been measured directly, it was estimated to be near 27 days. As a Southern Hemisphere target, it was not monitored by long-term stellar activity surveys, but archival International Ultraviolet Explorer data revealed a 12 yr activity cycle. Previous ground-based asteroseismology suggested that the star is slightly more massive and substantially larger and older than the Sun, so the similarity of both the rotation rate and the activity cycle period to solar values is perplexing. We use two months of precise time-series photometry from the Transiting Exoplanet Survey Satellite to detect solar-like oscillations in β Hyi and determine the fundamental stellar properties from asteroseismic modeling. We also obtain a direct measurement of the rotation period, which was previously estimated from an ultraviolet activity–rotation relation. We then use rotational evolution modeling to predict the rotation period expected from either standard spin-down or weakened magnetic braking (WMB). We conclude that the rotation period of β Hyi is consistent with WMB and that changes in stellar structure on the subgiant branch can reinvigorate the large-scale dynamo and briefly sustain magnetic activity cycles. Our results support the existence of a “born-again” dynamo in evolved subgiants—previously suggested to explain the cycle in 94 Aqr Aa—which can best be understood within the WMB scenario.

δ Scuti variables are found at the intersection of the classical instability strip and the main sequence on the Hertzsprung–Russell diagram. With space-based photometry providing millions of light curves of A-F type stars, we can now probe the occurrence rate of δ Scuti pulsations in detail. Using the 30 minutes cadence light curves from NASA's Transiting Exoplanet Survey Satellite's first 26 sectors, we identify variability in 103,810 stars within 5–24 cycles per day down to a magnitude of T = 11.25. We fit the period–luminosity relation of the fundamental radial mode for δ Scuti stars in the Gaia G band, allowing us to distinguish classical pulsators from contaminants for a subset of 39,367 stars. Out of this subset, over 15,918 are found on or above the expected period–luminosity relation. We derive an empirical red edge to the classical instability strip using Gaia photometry. The center where the pulsator fraction peaks at 50%–70%, combined with the red edge, agrees well with previous work in the Kepler field. While many variable sources are found below the period–luminosity relation, over 85% of sources inside of the classical instability strip derived in this work are consistent with being δ Scuti stars. The remaining 15% of variables within the instability strip are likely hybrid or γ Doradus pulsators. Finally, we discover strong evidence for a correlation between pulsator fraction and spectral line broadening from the Radial Velocity Spectrometer on board the Gaia spacecraft, confirming that rotation has a role in driving pulsations in δ Scuti stars.

Exoplanet discoveries have revealed a dramatic diversity of planet sizes across a vast array of orbital architectures. Sub-Neptunes are of particular interest; due to their absence in our own solar system, we rely on demographics of exoplanets to better understand their bulk composition and formation scenarios. Here, we present the discovery and characterization of TOI-1437 b, a sub-Neptune with a 18.84 day orbit around a near-solar analog ( M _⋆ = 1.10 ± 0.10 M _☉ , R _⋆ =1.17 ± 0.12 R _☉ ). The planet was detected using photometric data from the Transiting Exoplanet Survey Satellite (TESS) mission and radial velocity (RV) follow-up observations were carried out as a part of the TESS-Keck Survey using both the HIRES instrument at Keck Observatory and the Levy Spectrograph on the Automated Planet Finder telescope. A combined analysis of these data reveal a planet radius of R _p = 2.24 ± 0.23 R _⊕ and a mass measurement of M _p = 9.6 ± 3.9 M _⊕ ). TOI-1437 b is one of few (∼50) known transiting sub-Neptunes orbiting a solar-mass star that has a RV mass measurement. As the formation pathway of these worlds remains an unanswered question, the precise mass characterization of TOI-1437 b may provide further insight into this class of planet.

Small planets ( R _p ≤ 4 R _⊕ ) are divided into rocky super-Earths and gaseous sub-Neptunes separated by a radius gap, but the mechanisms that produce these distinct planet populations remain unclear. Binary stars are the only main-sequence systems with an observable record of the protoplanetary disk lifetime and mass reservoir, and the demographics of planets in binaries may provide insights into planet formation and evolution. To investigate the radius distribution of planets in binary star systems, we observed 207 binary systems hosting 283 confirmed and candidate transiting planets detected by the Kepler mission, then recharacterized the planets while accounting for the observational biases introduced by the secondary star. We found that the population of planets in close binaries ( ρ ≤ 100 au) is significantly different from the planet population in wider binaries ( ρ > 300 au) or single stars. In contrast to planets around single stars, planets in close binaries appear to have a unimodal radius distribution with a peak near the expected super-Earth peak of R _p ∼ 1.3 R _⊕ and a suppressed population of sub-Neptunes. We conclude that we are observing the direct impact of a reduced disk lifetime, smaller mass reservoir, and possible altered distribution of solids reducing the sub-Neptune formation efficiency. Our results demonstrate the power of binary stars as a laboratory for exploring planet formation and as a controlled experiment of the impact of varied initial conditions on mature planet populations.

We present a comprehensive multiwavelength investigation into flares and activity in nearby M dwarf stars. We leverage the most extensive contemporaneous data set obtained through the Transiting Exoplanet Sky Survey, Kepler/K2, the Neil Gehrels Swift Observatory, and the Hubble Space Telescope, spanning the optical and near-ultraviolet (NUV) regimes. In total, we observed 213 NUV flares on 24 nearby M dwarfs, with ∼27% of them having detected optical counterparts, and found that all optical flares had NUV counterparts. We explore NUV/optical energy fractionation in M dwarf flares. Our findings reveal a slight decrease in the ratio of optical to NUV energies with increasing NUV energies, a trend in agreement with prior investigations on G–K stars’ flares at higher energies. Our analysis yields an average NUV fraction of flaring time for M0–M3 dwarfs of 2.1%, while for M4–M6 dwarfs it is 5%. We present an empirical relationship between NUV and optical flare energies and compare to predictions from radiative hydrodynamic and blackbody models. We conducted a comparison of the flare frequency distribution (FFDs) of NUV and optical flares, revealing that the FFDs of both NUV and optical flares exhibit comparable slopes across all spectral subtypes. NUV flares on stars affect the atmospheric chemistry, the radiation environment, and the overall potential to sustain life on any exoplanets they host. We find that early and mid-M dwarfs (M0–M5) have the potential to generate NUV flares capable of initiating abiogenesis.

TOI-6255 b (GJ 4256) is an Earth-sized planet (1.079 ± 0.065 R _⊕ ) with an orbital period of only 5.7 hr. With the newly commissioned Keck Planet Finder and CARMENES spectrographs, we determine the planet’s mass to be 1.44 ± 0.14 M _⊕ . The planet is just outside the Roche limit, with P _orb / P _Roche = 1.13 ± 0.10. The strong tidal force likely deforms the planet into a triaxial ellipsoid with a long axis that is ∼10% longer than the short axis. Assuming a reduced stellar tidal quality factor ${Q}_{\star }^{{\prime} }\approx {10}^{7}$ , we predict that tidal orbital decay will cause TOI-6255 to reach the Roche limit in roughly 400 Myr. Such tidal disruptions may produce the possible signatures of planet engulfment that have been seen on stars with anomalously high refractory elemental abundances compared to their conatal binary companions. TOI-6255 b is also a favorable target for searching for star–planet magnetic interactions, which might cause interior melting and hasten orbital decay. TOI-6255 b is a top target (with an Emission Spectroscopy Metric of about 24) for phase-curve observations with the James Webb Space Telescope.

Stellar spin down is a critical yet poorly understood component of stellar evolution. In particular, results from the Kepler Mission imply that mature age, solar-type stars have inefficient magnetic braking, resulting in a stalled spin-down rate. However, a large number of precise asteroseismic ages are needed for mature (≥3 Gyr) stars in order to probe the regime where traditional and stalled spin-down models differ. In this paper, we present a new asteroseismic benchmark star for gyrochronology discovered using reprocessed Kepler short cadence data. KIC 11029516 (Papayu) is a bright ( Kp = 9.6 mag) solar-type star with a well-measured rotation period (21.1 ± 0.8 days) from spot modulation using 4 yr of Kepler long-cadence data. We combine asteroseismology and spectroscopy to obtain T _eff = 5888 ± 100 K, [Fe/H] = 0.30 ± 0.06 dex, M = 1.24 ± 0.05 M _⊙ , R = 1.34 ± 0.02 R _⊙ , and age of 4.0 ± 0.4 Gyr, making Papayu one of the most similar stars to the Sun in terms of temperature and radius with an asteroseismic age and a rotation period measured from spot modulation. We find that Papayu sits at the transition of where traditional and weakened spin-down models diverge. A comparison with stars of similar zero-age main-sequence temperatures supports previous findings that weakened spin-down models are required to explain the ages and rotation periods of old solar-type stars.

The degree of alignment between a star’s spin axis and the orbital plane of its planets (the stellar obliquity) is related to interesting and poorly understood processes that occur during planet formation and evolution. Hot Jupiters orbiting hot stars (≳6250 K) display a wide range of obliquities, while similar planets orbiting cool stars are preferentially aligned. Tidal dissipation is expected to be more rapid in stars with thick convective envelopes, potentially explaining this trend. Evolved stars provide an opportunity to test the damping hypothesis, particularly stars that were hot on the main sequence and have since cooled and developed deep convective envelopes. We present the first systematic study of the obliquities of hot Jupiters orbiting subgiants that recently developed convective envelopes using Rossiter–McLaughlin observations. Our sample includes two newly discovered systems in the Giants Transiting Giants survey (TOI-6029 b, TOI-4379 b). We find that the orbits of hot Jupiters orbiting subgiants that have cooled below ∼6250 K are aligned or nearly aligned with the spin axis of their host stars, indicating rapid tidal realignment after the emergence of a stellar convective envelope. We place an upper limit for the timescale of realignment for hot Jupiters orbiting subgiants at ∼500 Myr. Comparison with a simplified tidal evolution model shows that obliquity damping needs to be ∼4 orders of magnitude more efficient than orbital period decay to damp the obliquity without destroying the planet, which is consistent with recent predictions for tidal dissipation from inertial waves excited by hot Jupiters on misaligned orbits.

HIP 65426 hosts a young giant planet that has become the first exoplanet directly imaged with JWST. Using time-series photometry from the Transiting Exoplanet Survey Satellite (TESS), we classify HIP 65426 as a high-frequency δ Scuti pulsator with a possible large-frequency separation of Δ ν = 7.23 ± 0.02 cycles day ^−1 . We check the TESS data for pulsation-timing variations and use the nondetection to estimate a 95% dynamical mass upper limit of 12.8 M _Jup for HIP 65426 b. We also identify a low-frequency region of signal that we interpret as stellar latitudinal differential rotation with two rapid periods of 7.85 ± 0.08 hr and 6.67 ± 0.04 hr. We use our TESS rotation periods together with published values of radius and $v\sin i$ to jointly measure the inclination of HIP 65426 to ${i}_{\star }={107}_{-11}^{+12}$ °. Our stellar inclination is consistent with the orbital inclination of HIP 65426 b ( ${108}_{-3}^{+6}$ °) at the 68% percent level based on our orbit fit using published relative astrometry. The lack of significant evidence for spin–orbit misalignment in the HIP 65426 system supports an emerging trend consistent with preferential alignment between imaged long-period giant planets and their host stars.

Hot Neptunes, gaseous planets smaller than Saturn (∼3–8 R _⊕ ) with orbital periods less than 10 days, are rare. Models predict this is due to high-energy stellar irradiation stripping planetary atmospheres over time, often leaving behind only rocky planetary cores. Using our TESS full-frame-image pipeline giants in conjunction with Keck/HIRES radial velocity measurements, we present the discovery of TIC365102760 b, a 6.2 R _⊕ (0.55 R _J ), 19.2 M _⊕ (0.060 M _J ) planet transiting a red giant star every 4.21285 days. The old age and high equilibrium temperature yet remarkably low density of this planet ( ${\rho }_{p}={0.58}_{-0.20}^{+0.30}{\rho }_{{\rm{J}}}$ ) suggest that its gaseous envelope should have been stripped by high-energy stellar irradiation billions of years ago. The present-day planet mass and radius suggest the atmospheric stripping was slower than predicted. Unexpectedly low stellar activity and/or late-stage planet inflation could be responsible for the observed properties of this system. Further studies of this system with more precise photometry in multiple passbands will be capable of revealing more details of this planet’s atmosphere.

We confirm a massive sub-Neptune-sized planet on a P = 22.8 days orbit around the star TOI-1824 ( T _eff = 5200 K, V = 9.7 mag). TESS first identified TOI-1824 b (formerly TOI-1824.01) as an object of interest in 2020 April after two transits in Sector 22 were matched with a single transit in Sector 21. TOI-1824 was subsequently targeted for ground-based Doppler monitoring with Keck-HIRES and APF-Levy. Using a joint model of the TESS photometry, radial velocities, and Ca ii H and K emission measurements as an activity indicator, we find that TOI-1824 b is an unusually dense sub-Neptune. The planet has a radius R _p = 2.63 ± 0.15 R _⊕ and mass M _p = 18.5 ± 3.2 M _⊕ , implying a bulk density of 5.6 ± 1.4 g cm ^−3 . TOI-1824 b's mass and radius situate it near a small group of “superdense sub-Neptunes” ( R _p ≲ 3 R _⊕ and M _p ≳ 20 M _⊕ ). While the formation mechanism of superdense sub-Neptunes is a mystery, one possible explanation is the constructive collision of primordial icy cores; such giant impacts would drive atmospheric escape and could help explain these planets' apparent lack of massive envelopes. We discuss TOI-1824 b in the context of these overdense planets, whose unique location in the exoplanet mass–radius plane make them a potentially valuable tracer of planet formation.

The Transiting Exoplanet Survey Satellite (TESS) has discovered hundreds of new worlds, with TESS planet candidates now outnumbering the total number of confirmed planets from Kepler. Owing to differences in survey design, TESS continues to provide planets that are better suited for subsequent follow-up studies, including mass measurement through radial velocity (RV) observations, compared to Kepler targets. In this work, we present the TESS-Keck Survey’s (TKS) Mass Catalog: a uniform analysis of all TKS RV survey data that has resulted in mass constraints for 126 planets and candidate signals. This includes 58 mass measurements that have reached ≥5 σ precision. We confirm or validate 32 new planets from the TESS mission either by significant mass measurement (15) or statistical validation (17), and we find no evidence of likely false positives among our entire sample. This work also serves as a data release for all previously unpublished TKS survey data, including 9,204 RV measurements and associated activity indicators over our three-year survey. We took the opportunity to assess the performance of our survey and found that we achieved many of our goals, including measuring the mass of 38 small (

JWST has ushered in an era of unprecedented ability to characterize exoplanetary atmospheres. While there are over 5000 confirmed planets, more than 4000 Transiting Exoplanet Survey Satellite (TESS) planet candidates are still unconfirmed and many of the best planets for atmospheric characterization may remain to be identified. We present a sample of TESS planets and planet candidates that we identify as “best-in-class” for transmission and emission spectroscopy with JWST. These targets are sorted into bins across equilibrium temperature T _eq and planetary radius R _p and are ranked by a transmission and an emission spectroscopy metric (TSM and ESM, respectively) within each bin. We perform cuts for expected signal size and stellar brightness to remove suboptimal targets for JWST. Of the 194 targets in the resulting sample, 103 are unconfirmed TESS planet candidates, also known as TESS Objects of Interest (TOIs). We perform vetting and statistical validation analyses on these 103 targets to determine which are likely planets and which are likely false positives, incorporating ground-based follow-up from the TESS Follow-up Observation Program to aid the vetting and validation process. We statistically validate 18 TOIs, marginally validate 31 TOIs to varying levels of confidence, deem 29 TOIs likely false positives, and leave the dispositions for four TOIs as inconclusive. Twenty-one of the 103 TOIs were confirmed independently over the course of our analysis. We intend for this work to serve as a community resource and motivate formal confirmation and mass measurements of each validated planet. We encourage more detailed analysis of individual targets by the community.

We present and confirm TOI-1751 b, a transiting sub-Neptune orbiting a slightly evolved, solar-type, metal-poor star ( T _eff = 5996 ± 110 K, $\mathrm{log}(g)=4.2\pm 0.1$ , V = 9.3 mag, [Fe/H] = −0.40 ± 0.06 dex) every 37.47 days. We use TESS photometry to measure a planet radius of ${2.77}_{-0.07}^{+0.15}\,{R}_{\oplus }$ . We also use both Keck/HIRES and APF/Levy radial velocities (RV) to derive a planet mass of ${14.5}_{-3.14}^{+3.15}\,{M}_{\oplus }$ , and thus a planet density of 3.6 ± 0.9 g cm ^−3 . There is also a long-period (∼400 days) signal that is observed in only the Keck/HIRES data. We conclude that this long-period signal is not planetary in nature and is likely due to the window function of the Keck/HIRES observations. This highlights the role of complementary observations from multiple observatories to identify and exclude aliases in RV data. Finally, we investigate the potential compositions of this planet, including rocky and water-rich solutions, as well as theoretical irradiated ocean models. TOI-1751 b is a warm sub-Neptune with an equilibrium temperature of ∼820 K. As TOI-1751 is a metal-poor star, TOI-1751 b may have formed in a water-enriched formation environment. We thus favor a volatile-rich interior composition for this planet.

The extreme environments of ultra-short-period planets (USPs) make excellent laboratories to study how exoplanets obtain, lose, retain, and/or regain gaseous atmospheres. We present the confirmation and characterization of the USP TOI-1347 b, a 1.8 ± 0.1 R _⊕ planet on a 0.85 day orbit that was detected with photometry from the TESS mission. We measured radial velocities of the TOI-1347 system using Keck/HIRES and HARPS-N and found the USP to be unusually massive at 11.1 ± 1.2 M _⊕ . The measured mass and radius of TOI-1347 b imply an Earth-like bulk composition. A thin H/He envelope (>0.01% by mass) can be ruled out at high confidence. The system is between 1 and 1.8 Gyr old; therefore, intensive photoevaporation should have concluded. We detected a tentative phase-curve variation (3 σ ) and a secondary eclipse (2 σ ) in TESS photometry, which, if confirmed, could indicate the presence of a high-mean-molecular-weight atmosphere. We recommend additional optical and infrared observations to confirm the presence of an atmosphere and investigate its composition.

The Transiting Exoplanet Survey Satellite (TESS) continues to increase dramatically the number of known transiting exoplanets, and is optimal for monitoring bright stars amenable to radial velocity (RV) and atmospheric follow-up observations. TOI-1386 is a solar-type (G5V) star that was detected via TESS photometry to exhibit transit signatures in three sectors with a period of 25.84 days. We conducted follow-up RV observations using Keck/High Resolution Echelle Spectrometer (HIRES) as part of the TESS–Keck Survey, collecting 64 RV measurements of TOI-1386 with the HIRES spectrograph over 2.5 yr. Our combined fit of the TOI-1386 photometry and RV data confirm the planetary nature of the detected TESS signal, and provide a mass and radius for planet b of 0.148 ± 0.019 M _J and 0.540 ± 0.017 R _J , respectively, marking TOI-1386 b as a warm sub-Saturn planet. Our RV data further reveal an additional outer companion, TOI-1386 c, with an estimated orbital period of 227.6 days and a minimum mass of 0.309 ± 0.038 M _J . The dynamical modeling of the system shows that the measured system architecture is long-term stable, although there may be substantial eccentricity oscillations of the inner planet due to the dynamical influence of the outer planet.

The effect of stellar multiplicity on planetary architecture and orbital dynamics provides an important context for exoplanet demographics. We present a volume-limited catalog of up to 300 pc of 66 stars hosting planets and planet candidates from Kepler, K2, and TESS with significant Hipparcos-Gaia proper motion anomalies, which indicates the presence of companions. We assess the reliability of each transiting planet candidate using ground-based follow-up observations, and find that the TESS Objects of Interest (TOIs) with significant proper anomalies show nearly four times more false positives due to eclipsing binaries compared to TOIs with marginal proper anomalies. In addition, we find tentative evidence that orbital periods of planets orbiting TOIs with significant proper anomalies are shorter than those orbiting TOIs without significant proper anomalies, consistent with the scenario that stellar companions can truncate planet-forming disks. Furthermore, TOIs with significant proper anomalies exhibit lower Gaia differential velocities in comparison to field stars with significant proper anomalies, suggesting that planets are more likely to form in binary systems with low-mass substellar companions or stellar companions at wider separation. Finally, we characterize the three-dimensional architecture of LTT 1445 ABC using radial velocities, absolute astrometry from Gaia and Hipparcos, and relative astrometry from imaging. Our analysis reveals that LTT 1445 is a nearly flat system, with a mutual inclination of ∼2.°88 between the orbit of BC around A and that of C around B. This coplanarity may explain why multiple planets around LTT 1445 A survive in the dynamically hostile environments of this system.

The rodent visual system has attracted great interest in recent years due to its experimental tractability, but the fundamental mechanisms used by the mouse to represent the visual world remain unclear. In the primate, researchers have argued from both behavioral and neural evidence that a key step in visual representation is ‘figure-ground segmentation’, the delineation of figures as distinct from backgrounds. To determine if mice also show behavioral and neural signatures of figure-ground segmentation, we trained mice on a figure-ground segmentation task where figures were defined by gratings and naturalistic textures moving counterphase to the background. Unlike primates, mice were severely limited in their ability to segment figure from ground using the opponent motion cue, with segmentation behavior strongly dependent on the specific carrier pattern. Remarkably, when mice were forced to localize naturalistic patterns defined by opponent motion, they adopted a strategy of brute force memorization of texture patterns. In contrast, primates, including humans, macaques, and mouse lemurs, could readily segment figures independent of carrier pattern using the opponent motion cue. Consistent with mouse behavior, neural responses to the same stimuli recorded in mouse visual areas V1, RL, and LM also did not support texture-invariant segmentation of figures using opponent motion. Modeling revealed that the texture dependence of both the mouse’s behavior and neural responses could be explained by a feedforward neural network lacking explicit segmentation capabilities. These findings reveal a fundamental limitation in the ability of mice to segment visual objects compared to primates.

We studied 89 A- and F-type members of the Pleiades open cluster, including five escaped members. We measured projected rotational velocities ( $v\sin i$ ) for 49 stars and confirmed that stellar rotation causes a broadening of the main sequence in the color–magnitude diagram. Using time-series photometry from NASA’s TESS Mission (plus one star observed by Kepler/K2), we detected δ Scuti pulsations in 36 stars. The fraction of Pleiades stars in the middle of the instability strip that pulsate is unusually high (over 80%), and their range of effective temperatures agrees well with theoretical models. On the other hand, the characteristics of the pulsation spectra are varied and do not correlate with stellar temperature, calling into question the existence of a useful ${\nu }_{\max }$ relation for δ Scutis, at least for young main-sequence stars. By including δ Scuti stars observed in the Kepler field, we show that the instability strip is shifted to the red with increasing distance by interstellar reddening. Overall, this work demonstrates the power of combining observations with Gaia and TESS for studying pulsating stars in open clusters.

Abstract We investigated whether a nurse-led, telephone-based follow-up including medical titration was superior to usual care in improving blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) values 36 months after acute coronary syndrome (ACS). We screened all patients admitted with ACS at Östersund hospital, Sweden, between January 1, 2010, and December 31, 2014, for inclusion based on ability to participate in a telephone-based follow-up. Participants were randomly allocated to usual care or an intervention group that received counselling and medical titration to target BP

The features of vibrations provide key information on the surrounding environment. Here the authors show that a common computational principle underlies vibrotactile pitch perception in both mice and humans.

ObjectiveTo investigate the plasma proteomic profiling in identifying biomarkers related to return to sport (RTS) following a sport-related concussion (SRC).MethodsThis multicenter, prospective, case-control study was part of a larger cohort study conducted by the NCAA-DoD Concussion Assessment, Research, and Education (CARE) Consortium, athletes (n = 140) with blood collected within 48 h of injury and reported day to asymptomatic were included in this study, divided into two groups: (1) recovery

The success of galactic archeology and the reconstruction of the formation history of our Galaxy relies critically on precise ages for large populations of stars. For evolved stars in the red clump and red giant branch, the carbon-to-nitrogen ratio ([C/N]) has recently been identified as a powerful diagnostic of mass and age that can be applied to stellar samples from spectroscopic surveys such as Sloan Digital Sky Survey/APOGEE. Here, we show that at least 10% of red clump stars and red giant branch stars deviate from the standard relationship between [C/N] and mass. We use the APOGEE–Kepler (APOKASC) overlap sample to show that binary interactions are responsible for the majority of these outliers and that stars with indicators of current or previous binarity should be excluded from galactic archeology analyses that rely on [C/N] abundances to infer stellar masses. We also show that the Data Release 14 APOGEE analysis overestimates the surface gravities for even moderately rotating giants ( v sin i > 2 km s ^−1 ).

The Galactic bulge is critical to our understanding of the Milky Way. However, due to the lack of reliable stellar distances, the structure and kinematics of the bulge/bar beyond the Galactic center have remained largely unexplored. Here, we present a method to measure distances of luminous red giants using a period–amplitude–luminosity relation anchored to the Large Magellanic Cloud, with random uncertainties of 10%–15% and systematic errors below 1%–2%. We apply this method to data from the Optical Gravitational Lensing Experiment to measure distances to 190,302 stars in the Galactic bulge and beyond out to 20 kpc. Using this sample, we measure a distance to the Galactic center of R _0 = 8108 ± 106 _stat ± 93 _sys pc, consistent with direct measurements of stars orbiting Sgr A*. We cross-match our distance catalog with Gaia DR3 and use the subset of 39,566 overlapping stars to provide the first constraints on the Milky Way’s velocity field ( V _R , V _ϕ , V _z ) beyond the Galactic center. We show that the V _R quadrupole from the bar’s near side is reflected with respect to the Galactic center, indicating that the bar is bisymmetric and aligned with the inner disk. We also find that the vertical height V _Z map has no major structure in the region of the Galactic bulge, which is inconsistent with a current episode of bar buckling. Finally, we demonstrate with N -body simulations that distance uncertainty plays a factor in the alignment of the major and kinematic axes of the bar, necessitating caution when interpreting results for distant stars.

The bright star λ Ser hosts a hot Neptune with a minimum mass of 13.6 M _⊕ and a 15.5 day orbit. It also appears to be a solar analog, with a mean rotation period of 25.8 days and surface differential rotation very similar to the Sun. We aim to characterize the fundamental properties of this system and constrain the evolutionary pathway that led to its present configuration. We detect solar-like oscillations in time series photometry from the Transiting Exoplanet Survey Satellite, and we derive precise asteroseismic properties from detailed modeling. We obtain new spectropolarimetric data, and we use them to reconstruct the large-scale magnetic field morphology. We reanalyze the complete time series of chromospheric activity measurements from the Mount Wilson Observatory, and we present new X-ray and ultraviolet observations from the Chandra and Hubble space telescopes. Finally, we use the updated observational constraints to assess the rotational history of the star and estimate the wind braking torque. We conclude that the remaining uncertainty on the stellar age currently prevents an unambiguous interpretation of the properties of λ Ser, and that the rate of angular momentum loss appears to be higher than for other stars with a similar Rossby number. Future asteroseismic observations may help to improve the precision of the stellar age.

With JWST’s successful deployment and unexpectedly high fuel reserves, measuring the masses of sub-Neptunes transiting bright, nearby stars will soon become the bottleneck for characterizing the atmospheres of small exoplanets via transmission spectroscopy. Using a carefully curated target list and observations from more than 2 yr of APF-Levy and Keck-HIRES Doppler monitoring, the TESS-Keck Survey is working toward alleviating this pressure. Here we present mass measurements for 11 transiting planets in eight systems that are particularly suited to atmospheric follow-up with JWST. We also report the discovery and confirmation of a temperate super-Jovian-mass planet on a moderately eccentric orbit. The sample of eight host stars, which includes one subgiant, spans early-K to late-F spectral types ( T _eff = 5200–6200 K). We homogeneously derive planet parameters using a joint photometry and radial velocity modeling framework, discuss the planets’ possible bulk compositions, and comment on their prospects for atmospheric characterization.

We present measurements of the dipole mode asymptotic period spacing (ΔΠ _1 ), the coupling factor between the p - and g -modes ( q ), the g -mode phase offset ( ϵ _g ), and the mixed-mode frequency rotational splitting ( δ ν _rot ) for 1074 low-luminosity red giants from the Kepler mission. Using oscillation mode frequencies extracted from each star, we apply Bayesian optimization to estimate ΔΠ _1 from the power spectrum of the stretched-period spectrum and to perform the subsequent forward modeling of the mixed-mode frequencies. With our measurements, we show that the mode coupling factor q shows significant anticorrelation with both the stellar mass and metallicity, and can reveal highly metal-poor stars. We present the evolution of ϵ _g up the lower giant branch up to before the luminosity bump, and find no significant trends in ϵ _g or δ ν _rot with the stellar mass and metallicity in our sample. Additionally, we identify six new red giants showing anomalous distortions in their g -mode pattern. Our data products, code, and results are provided in a public repository.