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1. Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled study

Author

Lina Samira Bahr, Markus Bock, Daniela Liebscher, Judith Bellmann-Strobl, Liane Franz, Alexandra Prüß, Dania Schumann, Sophie K. Piper, Christian S. Kessler, Nico Steckhan, Andreas Michalsen, Friedemann Paul, and Anja Mähler

Subjects
Multiple sclerosis, Dietary intervention, Ketogenic diet, Intermittent fasting, Anti-inflammatory diet, Medicine (General), R5-920
Abstract

Abstract Background Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system in young adults that may lead to progressive disability. Since pharmacological treatments may have substantial side effects, there is a need for complementary treatment options such as specific dietary approaches. Ketone bodies that are produced during fasting diets (FDs) and ketogenic diets (KDs) are an alternative and presumably more efficient energy source for the brain. Studies on mice with experimental autoimmune encephalomyelitis showed beneficial effects of KDs and FDs on disease progression, disability, cognition and inflammatory markers. However, clinical evidence on these diets is scarce. In the clinical study protocol presented here, we investigate whether a KD and a FD are superior to a standard diet (SD) in terms of therapeutic effects and disease progression. Methods This study is a single-center, randomized, controlled, parallel-group study. One hundred and eleven patients with relapsing–remitting MS with current disease activity and stable immunomodulatory therapy or no disease-modifying therapy will be randomized to one of three 18-month dietary interventions: a KD with a restricted carbohydrate intake of 20–40 g/day; a FD with a 7-day fast every 6 months and 14-h daily intermittent fasting in between; and a fat-modified SD as recommended by the German Nutrition Society. The primary outcome measure is the number of new T2-weighted MRI lesions after 18 months. Secondary endpoints are safety, changes in relapse rate, disability progression, fatigue, depression, cognition, quality of life, changes of gut microbiome as well as markers of inflammation, oxidative stress and autophagy. Safety and feasibility will also be assessed. Discussion Preclinical data suggest that a KD and a FD may modulate immunity, reduce disease severity and promote remyelination in the mouse model of MS. However, clinical evidence is lacking. This study is the first clinical study investigating the effects of a KD and a FD on disease progression of MS. Trial registration ClinicalTrials.gov, NCT03508414. Retrospectively registered on 25 April 2018.

Published
2020
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2. Differences Between Omnivores and Vegetarians in Personality Profiles, Values, and Empathy: A Systematic Review

Author

Sophie Holler, Holger Cramer, Daniela Liebscher, Michael Jeitler, Dania Schumann, Vijayendra Murthy, Andreas Michalsen, and Christian S. Kessler

Subjects
vegetarian, plant-based, omnivore, diet, personality, values, Psychology, BF1-990
Abstract

Numerous medical studies have documented vegetarian diets as having various health benefits. Studies have also compared vegetarians with other dietary groups from a socio-psychological perspective. The objective of this review is to investigate the differences between vegetarians and omnivores in terms of their personality profiles, values, and empathy skills. A search was conducted across three electronic databases. Non-randomized, observational, cross-sectional, and cohort studies were eligible. Outcomes provided information about the differences between the above-mentioned dietary groups regarding their personality profiles, values, and empathy skills. A shortened version of the Newcastle–Ottawa Scale was used to assess the risk of bias for the included studies. Of the 2,513 different studies found, 25 (total number of participants n = 23,589) were ultimately included. These studies indicate that vegetarians significantly differ from omnivores in their personalities, values, and ability to be empathetic. Omnivorism is associated with an increased orientation toward social dominance, greater right-wing authoritarianism, and, in line with this, a stronger tendency to be prejudiced. Vegetarianism is associated with greater openness and empathy. The values of vegetarians are based more on universalism, hedonism, stimulation, and self-direction, whereas the values of omnivores are based more on the idea of power. To answer a narrowly defined and clear question, issues such as animal ethics, animal rights, and environmental protection are not considered in this review. The findings of this review, showing marked differences in personality correlating to the choice of diet and the increasing influence of plant-based diets on a global level, indicate that further studies about vegetarianism are warranted.

Published
2021
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3. Ayurvedic vs. Conventional Nutritional Therapy Including Low-FODMAP Diet for Patients With Irritable Bowel Syndrome—A Randomized Controlled Trial

Author

Michael Jeitler, Till Wottke, Dania Schumann, Laura M. Puerto Valencia, Andreas Michalsen, Nico Steckhan, Martin Mittwede, Elmar Stapelfeldt, Daniela Koppold-Liebscher, Holger Cramer, Manfred Wischnewsky, Vijayendra Murthy, and Christian S. Kessler

Subjects
nutrition – clinical, Traditional Indian Medicine, irritable bowel syndrome, Ayurveda, clinical trials, complementary medicine, Medicine (General), R5-920
Abstract

Aims: To compare the effects of Ayurvedic and conventional nutritional therapy in patients with irritable bowel syndrome (IBS).Methods: Sixty-nine patients with IBS were randomized to Ayurvedic (n = 35) or conventional nutritional therapy according to the recommendations of the German Nutrition Society including the low-FODMAP diet (n = 34). Study visits took place at baseline and after 1, 3, and 6 months. The primary outcome was IBS symptom severity (IBS-SSS) after 3 months; secondary outcomes included stress (CPSS), anxiety and depression (HADS), well-being (WHO-5) and IBS-specific quality of life (IBS-QOL). A repeated measures general linear model (GLM) for intent-to-treat-analyses was applied in this explorative study.Results: After 3 months, estimated marginal means for IBS-SSS reductions were 123.8 [95% confidence interval (95% CI) = 92.8–154.9; p < 0.001] in the Ayurvedic and 72.7 (95% CI = 38.8–106.7; p < 0.001) in the conventional group. The IBS-SSS reduction was significantly higher in the Ayurveda group compared to the conventional therapy group (estimated marginal mean = 51.1; 95% CI = 3.8–98.5; p = 0.035) and clinically meaningful. Sixty-eight percentage of the variance in IBS-SSS reduction after 3 months can be explained by treatment, 6.5% by patients' expectations for their therapies and 23.4% by IBS-SSS at pre-intervention. Both therapies are equivalent in their contribution to the outcome variance. The higher the IBS-SSS score at pre-intervention and the larger the patients' expectations, the greater the IBS-SSS reduction. There were no significant group differences in any secondary outcome measures. No serious adverse events occurred in either group.Conclusion: Patients with IBS seem to benefit significantly from Ayurvedic or conventional nutritional therapy. The results warrant further studies with longer-term follow-ups and larger sample sizes.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT03019861, identifier: NCT03019861.

Published
2021
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4. Efficacy of therapeutic fasting and plant-based diet in patients with rheumatoid arthritis (NutriFast): study protocol for a randomised controlled clinical trial

Author

Thomas Häupl, Anika M Hartmann, Melanie Dell'Oro, Christian S Kessler, Dania Schumann, Nico Steckhan, Michael Jeitler, Jan Moritz Fischer, Michaela Spoo, Martin A Kriegel, Jochen G Schneider, Farid I Kandil, Andreas Michalsen, and Daniela A Koppold-Liebscher

Subjects
Medicine
Abstract

Background Previous studies have shown beneficial effects of therapeutic fasting and plant-based dietary interventions on disease activity in patients with rheumatoid arthritis (RA) for a duration of up to 1 year. To date, the effects of such interventions on the gut microbiome and on modern diagnostic markers in patients with RA have not been studied. This trial aims to investigate the clinical effects of therapeutic fasting and a plant-based diet in patients with RA, additionally considering current immunological diagnostic tools and microbiome analyses.Methods/design This trial is an open-label, single-centre, randomised, controlled, parallel-group clinical trial. We will randomly assign 84 patients with RA under a stable standard therapy to either (1) therapeutic fasting followed by a plant-based dietary intervention or (2) to a conventional nutritional counselling focusing on an anti-inflammatory dietary pattern according to the recommendations of the Deutsche Gesellschaft für Ernährung (German society for nutrition). Primary outcome parameter is the group difference from baseline to 12 weeks on the Health Assessment Questionnaire (HAQ). Other secondary outcomes include established clinical criteria for disease activity and treatment response in RA (Disease Activity Score 28, Simple Disease Activity Index, ACR-Response Criteria), changes in self-reported health and physical functional ability, mood, stress, quality of life, dietary behaviour via 3-day food records and a modified Food Frequency Questionnaire, body composition, changes in the gut microbiome, metabolomics and cytometric parameters. Outcomes will be assessed at baseline and day 7, after 6 weeks, 12 weeks and after 6 months.Ethics and dissemination Ethical approval to process and analyse data, and to publish the results was obtained through the institutional review board of Charité-Universitätsmedizin Berlin. Results of this trial will be disseminated through peer-reviewed publications and scientific presentations.Trial registration number NCT03856190.

Published
2021
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5. Adverse effects of yoga: a national cross-sectional survey

Author

Holger Cramer, Daniela Quinker, Dania Schumann, Jon Wardle, Gustav Dobos, and Romy Lauche

Subjects
Yoga, Injuries, Adverse effects, Safety, Epidemiology, Other systems of medicine, RZ201-999
Abstract

Abstract Background While yoga is increasingly used for health purposes, its safety has been questioned. The aim of this cross-sectional survey was to analyze yoga-associated adverse effects and their correlates. Methods A cross-sectional anonymous national online survey among German yoga practitioners (n = 1702; 88.9% female; 47.2 ± 10.8 years) was conducted from January to June 2016. Participants were queried regarding their yoga practice, i.e. yoga styles used, length and intensity of yoga practice, practice patterns, and whether they had experienced acute or chronic adverse effects of their yoga practice. Independent predictors of acute or chronic adverse effects were identified using multiple logistic regression analyses. Results Ashtanga yoga (15.7%), traditional Hatha yoga (14.2%), and Sivananda yoga (22.4%) were the most commonly used yoga styles. 364 (21.4%) yoga users reported 702 acute adverse effects, occurring after a mean of 7.6 ± 8.0 years of yoga practice. The most commonly reported yoga practices that were associated with acute adverse effects were hand-, shoulder- and head stands (29.4%). Using Viniyoga was associated with a decreased risk of acute adverse effects; practicing only by self-study without supervision was associated with higher risk. One hundred seventy-three participants (10.2%) reported 239 chronic adverse effects. The risk of chronic adverse effects was higher in participants with chronic illnesses and those practicing only by self-study without supervision. Most reported adverse effects concerned the musculoskeletal system. 76.9% of acute cases, and 51.6% of chronic cases reached full recovery. On average 0.60 injuries (95% confidence interval = 0.51–0.71) per 1000 h of practice were reported, with Power yoga users reporting the highest rate (1.50 injuries per 1000 h; 95% confidence interval = 0.98–3.15). Conclusions One in five adult yoga users reported at least one acute adverse effect in their yoga practice, and one in ten reported at least one chronic adverse effect, mainly musculoskeletal effects. Adverse effects were associated with hand-, shoulder- and head stands; and with yoga self-study without supervision. More than three quarters of of cases reached full recovery. Based on the overall injury rate per 1000 practice hours, yoga appears to be as safe or safer when compared to other exercise types.

Published
2019
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6. World Congress Integrative Medicine & Health 2017: Part one

Author

Benno Brinkhaus, Torkel Falkenberg, Aviad Haramati, Stefan N. Willich, Josephine P. Briggs, Merlin Willcox, Klaus Linde, Töres Theorell, Lisa M. Wong, Jeffrey Dusek, Darong Wu, David Eisenberg, Bettina Berger, Kathi Kemper, Beate Stock-Schröer, Hedda Sützl-Klein, Rosaria Ferreri, Gary Kaplan, Harald Matthes, Gabriele Rotter, Elad Schiff, Zahi Arnon, Eckhard Hahn, Christina M. Luberto, David Martin, Silke Schwarz, Diethard Tauschel, Andrew Flower, Harsha Gramminger, Hedwig H. Gupta, S. N. Gupta, Annette Kerckhoff, Christian S. Kessler, Andreas Michalsen, Eun S. Kim, Eun H. Jang, Rana Kim, Sae B. Jan, Martin Mittwede, Wiebke Mohme, Eran Ben-Arye, Massimo Bonucci, Bashar Saad, Thomas Breitkreuz, Elio Rossi, Rejin Kebudi, Michel Daher, Samaher Razaq, Nahla Gafer, Omar Nimri, Mohamed Hablas, Gunver Sophia Kienle, Noah Samuels, Michael Silbermann, Lena Bandelin, Anna-Lena Lang, Eva Wartner, Christoph Holtermann, Maxwell Binstock, Robert Riebau, Edin Mujkanovic, Holger Cramer, Romy Lauche, Andres Michalsen, Lesley Ward, Dominik Irnich, Wolfram Stör, Geoffrey Burnstock, Hans-Georg Schaible, Thomas Ots, Jost Langhorst, Tobias Sundberg, Catherina Amarell, Melanie Anheyer, Marion Eckert, Mercedes Ogal, Annette Schönauer, Birgit Reisenberger, Bernhard Brand, Dennis Anheyer, Gustav Dobos, Matthias Kroez, Aldo Ammendola, Jun J. Mao, Claudia Witt, Yufei Yang, Miriam Oritz, Markus Horneber, Petra Voiß, Alexandra von Rosenstiel, Catharina Amarell, Friedemann Schad, Marc Schläppi, Matthias Kröz, Arndt Büssing, Gil Bar-Sela, David Avshalomov, Samuel Attias, Sian Cotton, Miek Jong, Mats Jong, Christian Scheffer, Friedrich Edelhäuser, Abdullah AlBedah, Myeong Soo Lee, Mohamed Khalil, Keiko Ogawa, Yoshiharu Motoo, Junsuke Arimitsu, Masao Ogawa, Genki Shimizu, Rainer Stange, Karin Kraft, Kenny Kuchta, Kenji Watanabe, D Bonin, Harald Gruber, Sabine Koch, Urs Pohlmann, Christine Caldwell, Barbara Krantz, Ria Kortum, Lily Martin, Lisa S. Wieland, Ben Kligler, Susan Gould-Fogerite, Yuqing Zhang, John J. Riva, Michael Lumpkin, Emily Ratner, Liu Ping, Pei Jian, Gesa-Meyer Hamme, Xiaosong Mao, Han Chouping, Sven Schröder, Josef Hummelsberger, Michael Wullinger, Marc Brodzky, Christoff Zalpour, Julia Langley, Wendy Weber, Lanay M. Mudd, Peter Wayne, Clauda Witt, Wolfgang Weidenhammer, Vinjar Fønnebø, Heather Boon, Amie Steel, Andrea Bugarcic, Melisa Rangitakatu, Jon Adams, David Sibbritt, Jon Wardle, Matthew Leach, Janet Schloss, Helene Dieze, Nadine Ijaz, Michael Heinrich, George Lewith, Bertrand Graz, Daniela Adam, Linus Grabenhenrich, Miriam Ortiz, Sylvia Binting, Thomas Reinhold, Susanne Andermo, Johanna Hök Nordberg, Maria Arman, Manoj Bhasin, Xueyi Fan, Towia Libermann, Gregory Fricchione, John Denninger, Herbert Benson, David D. Martin, Inge Boers, Arine Vlieger, Michael Teut, Alexander Ullmann, Fabian Lotz, Stephanie Roll, Claudia Canella, Michael Mikolasek, Matthias Rostock, Jörg Beyer, Matthias Guckenberger, Josef Jenewein, Esther Linka, Claudia Six, Sarah Stoll, Roger Stupp, Claudia M. Witt, Elisabeth Chuang, Melissa D. McKee, Petra Klose, Silke Lange, Vincent C. H. Chung, Hoi L. C. Wong, Xin Y. Wu, Grace Y. G. Wen, Robin S. T. Ho, Jessica Y. L. Ching, Justin C. Y. Wu, Amanda Coakley, Jane Flanagan, Christine Annese, Joanne Empoliti, Zishan Gao, Xugang Liu, Shuguang Yu, Xianzhong Yan, Fanrong Liang, Christoph D. Hohmann, Nico Steckhan, Thomas Ostermann, Arion Paetow, Evelyn Hoff, Xiao-Yang Hu, Ruo-Han Wu, Martin Logue, Clara Blonde, Lily Y. Lai, Beth Stuart, Yu-Tong Fei, Michael Moore, Jian-Ping Liu, Michael Jeitler, Hannah Zillgen, Manuel Högl, Barbara Stöckigt, Georg Seifert, Christian Kessler, Talat Khadivzadeh, Maryam Hassanzadeh Bashtian, Shapour Badiee Aval, Habibollah Esmaily, Jihye Kim, Keun H. Kim, Carina Klocke, Stefanie Joos, Abdulrahman Koshak, Li Wie, Emad Koshak, Siraj Wali, Omer Alamoudi, Abdulrahman Demerdash, Majdy Qutub, Peter Pushparaj, Sigrid Kruse, Isabell Fischer, Nadine Tremel, Joseph Rosenecker, Brenda Leung, Wendy Takeda, Ning Liang, Xue Feng, Jian-ping Liu, Hui-juan Cao, Nina Shinday, Lisa Philpotts, Elyse Park, Gregory L. Fricchione, Gloria Yeh, Niki Munk, Arash Zakeresfahani, Trevor R. Foote, Rick Ralston, Karen Boulanger, Dominik Özbe, Elmar Gräßel, Katharina Luttenberger, Anna Pendergrass, Daniel Pach, Judit Bellmann-Strobl, Yinhui Chang, Laura Pasura, Bin Liu, Sven F. Jäger, Ronny Loerch, Li Jin, Katja Icke, Xuemin Shi, Friedemann Paul, Michaela Rütz, Andreas Lynen, Meike Schömitz, Maik Vahle, Nir Salomon, Alon Lang, Adi Lahat, Uri Kopylov, Shomron Ben-Horin, Ofir Har-Noi, Benjamin Avidan, Rami Elyakim, Dorit Gamus, Siew NG, Jessica Chang, Justin Wu, John Kaimiklotis, Dania Schumann, Ludovica Buttó, Dirk Haller, Caroline Smith, Sheryl de Lacey, Michael Chapman, Julie Ratcliffe, Neil Johnson, Jane Lyttleton, Clare Boothroyd, Paul Fahey, Bram Tjaden, Marja van Vliet, Herman van Wietmarschen, Wilfried Tröger, Pia Vuolanto, Paulina Aarva, Minna Sorsa, Kaija Helin, Claudia Wenzel, Iris Zoderer, Patricia Pammer, Patrick Simon, Gerhard Tucek, Kathrin Wode, Roger Henriksson, Lena Sharp, Anna Stoltenberg, Yang Xiao-ying, Li-qiong Wang, Jin-gen Li, Ying Wang, Lynda Balneaves, Rielle Capler, Chiara Bocci, Marta Guffi, Marina Paolini, Ilaria Meaglia, Patrizia Porcu, Giovanni B. Ivaldi, Simona Dragan, Petru Bucuras, Ana M. Pah, Marius Badalica-Petrescu, Florina Buleu, Gheorghe Hogea-Stoichescu, Ruxandra Christodorescu, Lan Kao, Yumin Cho, Nadja Klafke, Cornelia Mahler, Cornelia von Hagens, Lorenz Uhlmann, Martina Bentner, Andreas Schneeweiss, Andreas Mueller, Joachim Szecsenyi, Isabella Neri, Katharina Schnabel, Margit Cree, Ralf Suhr, Sonia Baccetti, Fabio Firenzuoli, Maria V. Monechi, Mariella Di Stefano, Gianni Amunni, Wendy Wong, Bingzhong Chen, Hakima Amri, Lucy Kotlyanskaya, Belinda Anderson, Roni Evans, Paul Marantz, Ryan Bradley, Cathryn Booth-LaForce, Heather Zwickey, Benjamin Kligler, Audrey Brooks, Mary J. Kreitzer, Patricia Lebensohn, Elisabeth Goldblatt, Neus Esmel-Esmel, Maria Jiménez-Herrera, Alexandra Jocham, Pascal O. Berberat, Antonius Schneider, Morgana Masetti, Henriette Murakozy, Marja Van Vliet, Rita Agdal, Fatemeh Atarzadeh, Amir M. Jaladat, Leila Hoseini, Fatemeh Amini, Chen Bai, Tiegang Liu, Zian Zheng, Yuxiang Wan, Jingnan Xu, Xuan Wang, He Yu, Xiaohong Gu, Babak Daneshfard, Majid Nimrouzi, Vahid Tafazoli, Seyed M. Emami Alorizi, Seyed A. Saghebi, Mohammad R. Fattahi, Alireza Salehi, Hossein Rezaeizadeh, Mohammad M. Zarshenas, Kealoha Fox, John Hughes, Nenad Kostanjsek, Stéphane Espinosa, Peter Fisher, Abdul Latif, Donald Lefeber, William Paske, Ali Ö. Öztürk, Gizemnur Öztürk, Wim Tissing, Marianne Naafs, Martine Busch, Mohammad R. Sanaye, Kilian Dräger, Brent Leininger, Kate Shafto, Jenny Breen, Ana P. Simões-Wüst, Carolina Moltó-Puigmartí, Martien van Dongen, Pieter Dagnelie, Carel Thijs, Shelley White, Solveig Wiesener, Anita Salamonsen, Trine Stub, Sergio Abanades, Mar Blanco, Laia Masllorens, Roser Sala, Shafekah Al-Ahnoumy, Dongwoon Han, Luzhu He, Ha Yun Kim, Da In Choi, Terje Alræk, Agnete Kristoffersen, Christel von Sceidt, Stig Bruset, Frauke Musial, Felix J. Saha, Heidemarie Haller, Hoda Azizi, Nayereh Khadem, Malihe Hassanzadeh, Nazanin Estiri, Hamideh Azizi, Fatemeh Tavassoli, Marzieh Lotfalizadeh, Reza Zabihi, Mahmoud Mohammadzadeh Shabestari, Reza Paeizi, Masoumeh Alvandi Azari, Hamidreza Bahrami-Taghanaki, Erik Baars, Anja De Bruin, Anne Ponstein, Sergio Segantini, Maria Valeria Monechi, Fabio Voller, Jürgen Barth, Alexandra Kern, Sebastian Lüthi, Anja Zieger, Fabius Otto, Ariel Beccia, Corina Dunlap, Brendan Courneene, Paula Bedregal, Alvaro Passi, Alfredo Rodríguez, Mayling Chang, Soledad Gutiérrez, Florian Beissner, Christine Preibisch, Annemarie Schweizer-Arau, Roxana Popovici, Karin Meissner, Sylvie Beljanski, Laura Belland, Laura Rivera-Reyes, Ula Hwang, Dominik Sethe, Dörte Hilgard, Peter Heusser, Felicity Bishop, Miznah Al-Abbadey, Katherine Bradbury, Dawn Carnes, Borislav Dimitrov, Carol Fawkes, Jo Foster, Hugh MacPherson, Lisa Roberts, Lucy Yardley, Michelle Holmes, Paul Little, Cyrus Cooper, Patrizia Bogani, Valentina Maggini, Eugenia Gallo, Elisangela Miceli, Sauro Biffi, Alessio Mengoni, Renato Fani, Nadine Brands-Guendling, Peter W. Guendling, Gert Bronfort, Mitch Haas, Craig Schulz, Xiangwei Bu, J. Wang, T. Fang, Z. Shen, Y. He, X. Zhang, Zhengju Zhang, Dali Wang, Fengxian Meng, Klaus Baumann, Eckhard Frick, Christoph Jacobs, Ralph-Achim Grünther, Désirée Lötzke, Sonny Jung, Daniela R. Recchia, Sibylle Robens, Josephin Stankewitz, Mika Jeitler, Chunhoo Cheon, Bo H. Jang, Seong G. Ko, Ching W. Huang, Yui Sasaki, Youme Ko, Anna Cheshire, Damien Ridge, David Peters, Maria Panagioti, Chantal Simon, Hyun J. Cho, Soo J. Choi, Young S. Jung, Hyea B Im, Kieran Cooley, Laura Tummon-Simmons, Rachel Wasson, Kristen Kraemer, Richard Sears, Carly Hueber, Gwendolyn Derk, JR Lill, Ruopeng An, Lois Steinberg, Lourdes Diaz Rodriguez, Francisca García-de la Fuente, Miguel De la Vega, Keyla Vargas-Román, Jonatan Fernández-Ruiz, Irene Cantarero-Villanueva, Francisca García-De la Fuente, Fanny Jiménez-Guerrero, Noelia Galiano-Castillo, Gualberto Diaz-Saez, José I. Torres-Jimenez, Olga Garcia-Gomez, Luis Hortal-Muñoz, Camino Diaz-Diez, Demijon Dicen, Helene Diezel, Jane Frawley, Alex Broom, Fei Dong, Xueyan Ma, Liyi Yan, Liqun Wu, Jiaju Ma, Jianhua Zhen, Julie Dubois, Pierre-Yves Rodondi, Sophia Schwartze, Barbara Trapp, and Dirk Cysarz

Subjects
Other systems of medicine, RZ201-999
Published
2017
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7. World Congress Integrative Medicine & Health 2017: part two

Author

Carolyn Ee, Sharmala Thuraisingam, Marie Pirotta, Simon French, Charlie Xue, Helena Teede, Agnete E. Kristoffersen, Fuschia Sirois, Trine Stub, Jennifer Engler, Stefanie Joos, Corina Güthlin, Jennifer Felenda, Christiane Beckmann, Florian Stintzing, Roni Evans, Gert Bronfort, Daniel Keefe, Anna Taberko, Linda Hanson, Alex Haley, Haiwei Ma, Joseph Jolton, Lana Yarosh, Francis Keefe, Jung Nam, Liwanag Ojala, Mary J. Kreitzer, Careen Fink, Karin Kraft, Andrew Flower, George Lewith, Kim Harman, Beth Stuart, Felicity L. Bishop, Jane Frawley, Lilla Füleki, Eva Kiss, Tamas Vancsik, Tibor Krenacs, Martha Funabashi, Katherine A. Pohlman, Silvano Mior, Haymo Thiel, Michael D. Hill, David J. Cassidy, Michael Westaway, Jerome Yager, Eric Hurwitz, Gregory N. Kawchuk, Maeve O’Beirne, Sunita Vohra, Isabelle Gaboury, Chantal Morin, Katharina Gaertner, Loredana Torchetti, Martin Frei-Erb, Michael Kundi, Michael Frass, Eugenia Gallo, Valentina Maggini, Mattia Comite, Francesco Sofi, Sonia Baccetti, Alfredo Vannacci, Mariella Di Stefano, Maria V. Monechi, Luigi Gori, Elio Rossi, Fabio Firenzuoli, Rocco D. Mediati, Giovanna Ballerini, Paula Gardiner, Anna S. Lestoquoy, Lily Negash, Sarah Stillman, Prachi Shah, Jane Liebschutz, Pamela Adelstein, Christine Farrell-Riley, Ivy Brackup, Brian Penti, Robert Saper, Isabel Giralt Sampedro, Gilda Carvajal, Andreas Gleiss, Marie M. Gross, Dorothea Brendlin, Jonas Röttger, Wiebke Stritter, Georg Seifert, Noelle Grzanna, Rainer Stange, Peter W. Guendling, Wen Gu, Yan Lu, Jie Wang, Chengcheng Zhang, Hua Bai, Yuxi He, Xiaoxu Zhang, Zhengju Zhang, Dali Wang, Fengxian Meng, Alexander Hagel, Heinz Albrecht, Claudia Vollbracht, Wolfgang Dauth, Wolfgang Hagel, Francesco Vitali, Ingo Ganzleben, Hans Schultis, Peter Konturek, Jürgen Stein, Markus Neurath, Martin Raithel, Bianka Krick, Heidemarie Haller, Petra Klose, Gustav Dobos, Sherko Kümmel, Holger Cramer, Felix J. Saha, Anna Kowoll, Barbara Ebner, Bettina Berger, Kyung-Eun Choi, Lisha He, Han Wang, X. He, C. Gu, Y. Zhang, Linhua Zhao, Xiaolin Tong, Xinhui He, Chengjuan Gu, Ying Zhang, Robin S. T. Ho, Vincent C. H. Chung, Xinyin Wu, Charlene H. L. Wong, Justin C. Y. Wu, Samuel Y. S. Wong, Alexander Y. L. Lau, Regina W. S. Sit, Wendy Wong, Michelle Holmes, Felicity Bishop, Lynn Calman, Dave Newell, Jonathan Field, Win L. Htut, Dongwoon Han, Da I. Choi, Soo J. Choi, Ha Y. Kim, Jung H. Hwang, Ching W. Huang, Bo H. Jang, Fang P. Chen, Seong G. Ko, Wenjing Huang, De Jin, Fengmei Lian, Soobin Jang, Kyeong H. Kim, Eun K. Lee, Seung H. Sun, Ho Y. Go, Youme Ko, Sunju Park, Yong C. Shin, Hubert Janik, Natalie Greiffenhagen, Jürgen Bolte, Mariusz Jaworski, Miroslawa Adamus, Aleksandra Dobrzynska, Michael Jeitler, Jessica Jaspers, Christel von Scheidt, Barbara Koch, Andreas Michalsen, Nico Steckhan, Christian Kessler, Wen-jing Huang, Bing Pang, Feng-Mei Lian, Miek Jong, Erik Baars, Anja Glockmann, Harald Hamre, Mosaburo Kainuma, Aya Murakami, Toshio Kubota, Daisuke Kobayashi, Yasuhiro Sumoto, Norihiro Furusyo, Shin-Ichi Ando, Takao Shimazoe, Olaf Kelber, S. Verjee, Eva Gorgus, Dieter Schrenk, Kathi Kemper, Ellie Hill, Nisha Rao, Gregg Gascon, John Mahan, Gunver Kienle, Jörg Dietrich, Claudia Schmoor, Roman Huber, Weon H. Kim, Mansoor Ahmed, Luzhu He, Jung Hye Hwang, Nora Meggyeshazi, Csaba Kovago, Anne K. Klaus, Roland Zerm, Danilo Pranga, Thomas Ostermann, Marcus Reif, Hans Broder von Laue, Benno Brinkhaus, Matthias Kröz, Daniela Rodrigues Recchia, Hans B. von Laue, Christien T. Klein-Laansma, Mats Jong, Cornelia von Hagens, Jean P. Jansen, Herman van Wietmarschen, Miek C. Jong, Seung-Ho Sun, Ho-Yeon Go, Chan-Yong Jeon, Yun-Kyung Song, Seong-Gyu Ko, Anna K. Koch, Sybille Rabsilber, Romy Lauche, Jost Langhorst, Milena Trifunovic-Koenig, Evi Koster, Diana Delnoij, Lena Kroll, Kathrin Weiss, Ai Kubo, Sarah Hendlish, Andrea Altschuler, Nancy Connolly, Andy Avins, Jon Wardle, David Lee, David Sibbritt, Jon Adams, Crystal Park, Gita Mishra, Johann Lechner, Inseon Lee, Younbyoung Chae, Jisu Lee, Seung H. Cho, Yujin Choi, Jee Y. Lee, Han S. Ryu, Sung S. Yoon, Hye K. Oh, Lyun K. Hyun, Jin O. Kim, Seong W. Yoon, Ju-Yeon Lee, Sang-Hoon Shin, Min Jang, Indra Müller, So-Hyun Janson Park, Lance Laird, Suzanne Mitchell, Xiaofei Li, Yunhui Wang, Jianhua Zhen, He Yu, Tiegang Liu, Xiaohong Gu, Hui Liu, Weiguo Ma, Xuezheng Shang, Yu Bai, Wei Liu, Collin Rooney, Amos Smith, Shirlene Lopes, Marcelo Demarzo, Maria do Patrocínio Nunes, Peter Lorenz, Carsten Gründemann, Miriam Heinrich, Manuel Garcia-Käufer, Franziska Grunewald, Silke Messerschmidt, Anja Herrick, Kim Gruber, Matthias Knödler, Carmen Steinborn, Taoying Lu, Lixin Wang, Darong Wu, Christina M Luberto, Daniel L. Hall, Emma Chad-Friedman, Suzanne Lechner, Elyse R. Park, Christina M. Luberto, Elyse Park, Janice Goodman, Sonja Luer, Matthias Heri, Klaus von Ammon, Ida Landini, Andrea Lapucci, Stefania Nobili, Enrico Mini, Clare McDermott, Selwyn Richards, Diane Cox, Sarah Frossell, Geraldine Leydon, Caroline Eyles, Hilly Raphael, Rachael Rogers, Michelle Selby, Charlotte Adler, Jo Allam, Xiangwei Bu, Honghong Zhang, Jianpeng Zhang, Michael Mikolasek, Jonas Berg, Claudia Witt, Jürgen Barth, Ivan Miskulin, Zdenka Lalic, Maja Miskulin, Albina Dumic, Damir Sebo, Aleksandar Vcev, Nasr A. A. Mohammed, Soo Jeung Choi, Hyea Bin Im, Anwesha Mukherjee, Amit Kandhare, Subhash Bodhankar, Prasad Thakurdesai, Niki Munk, Erica Evans, Amanda Froman, Matthew Kline, Matthew J. Bair, Frauke Musial, Terje Alræk, Harald J. Hamre, Lars Björkman, Vinjar M. Fønnebø, Feng-mei Lian, Qing Ni, Xiao-lin Tong, Xin-long Li, Wen-ke Liu, Shuo Feng, Xi-yan Zhao, Yu-jiao Zheng, Xue-min Zhao, Yi-qun Lin, Tian-yu Zhao, Xi-Yan Zhao, Hui Che Phd, Chen Zhang, Feng Liu, Lin-hua Zhao, Ru Ye, Cheng-juan Gu, Wenbo Peng, Diana De Carvalho, Mohamed El-Bayoumi, Bob Haig, Kimbalin Kelly, Darrell J. Wade, Emanuela Portalupi, Giampietro Gobo, Luigi Bellavita, Chiara Guglielmetti, Christa Raak, Myriam Teuber, Friedrich Molsberger, Ulrich von Rath, Ulrike Reichelt, Uta Schwanebeck, Sabine Zeil, Christian Vogelberg, Dolores Rodríguez Veintimilla, Guerrero Tapia Mery, Marisol Maldonado Villavicencio, Sandra Herrera Moran, Christian Sachse, Peter W Gündlin, Monirsadat Sahebkarkhorasani, Hoda Azizi, Dania Schumann, Tobias Sundberg, Matthew J. Leach, Susana Seca, Henry Greten, Sugir Selliah, Anu Shakya, Ha Yun Kim, Hyea B. Im, Anna Sherbakova, Gudrun Ulrich-Merzenich, Heba Abdel-Aziz, Erica Sibinga, Lindsey Webb, Jonathan Ellen, Kari Skrautvol, Dagfinn Nåden, Rhayun Song, Weronika Grabowska, Kamila Osypiuk, Gloria V. Diaz, Paolo Bonato, Moonkyoung Park, Jeffrey Hausdorff, Michael Fox, Lewis R. Sudarsky, Daniel Tarsy, James Novakowski, Eric A. Macklin, Peter M. Wayne, Inok Hwang, Sukhee Ahn, Myung-Ah Lee, Min K. Sohn, Oleg Sorokin, Dagmar Heydeck, Astrid Borchert, Christoph-Daniel Hohmann, Harmut Kühn, Clemens Kirschbaum, Tobias Stalder, Barbara Stöckigt, Michael Teut, Ralf Suhr, Daniela Sulmann, Chris Streeter, Patrica Gerbarg, Marisa Silveri, Richard Brown, John Jensen, Britta Rutert, Angelika Eggert, Alfred Längler, Christine Holmberg, Jin Sun, Xin Deng, Wen-Yuan Li, Bin Wen, Nicola Robinson, Jian-Ping Liu, Hyun K. Sung, Narae Yang, Seon M. Shin, Hee Jung, Young J. Kim, Woo S. Jung, Tae Y. Park, Kiyoshi Suzuki, Toshinori Ito, Seiya Uchida, Seika Kamohara, Naoya Ono, Mitsuyuki Takamura, Ayumu Yokochi, Kazuo Maruyama, Patricio Tapia, Katarzyna Thabaut, Anja Thronicke, Megan Steele, Harald Matthes, Cornelia Herbstreit, Friedemann Schad, Jiaxing Tian, Libo Yang, Tian Tian, Hewei Zhang, Xia Tian, CongCong Wang, Qian Yun Chai, Lijuan Zhang, Ruyu Xia, Na Huang, Yutong Fei, Jianpin Liu, Natalie Trent, Mindy Miraglia, Jeffrey Dusek, Edi Pasalis, Sat B. Khalsa, Milena Trifunovic-König, Anna Koch, Lisa Uebelacker, Geoffrey Tremont, Lee Gillette, Gary Epstein-Lubow, David Strong, Ana Abrantes, Audrey Tyrka, Tanya Tran, Brandon Gaudiano, Ivan Miller, Gerhild Ullmann, Yuhua Li, Sujata Vaidya, Vinod Marathe, Ana C. Vale, Jacquelyne Motta, Fabíola Donadão, Angela C. Valente, Luana C. Carvalho Valente, Ricardo Ghelman, Dusan Vesovic, Dragan Jevdic, Aleksandar Jevdic, Katarina Jevdic, Mihael Djacic, Dragica Letic, Drago Bozic, Marija Markovic, Slobodan Dunjic, Gordana Ruscuklic, Dezire Baksa, Kenan Vrca, Ann Vincent, Dietlind Wahner-Roedler, Mary Whipple, Maria M. Vogelius, Iris Friesecke, Peter W. Gündling, Saswati Mahapatra, Rebecca Hynes, Kimberly Van Rooy, Sherry Looker, Aditya Ghosh, Brent Bauer, Susanne Cutshall, Harald Walach, Ana Borges Flores, Michael Ofner, Andreas Kastner, Gerhard Schwarzl, Hermann Schwameder, Nathalie Alexander, Gerda Strutzenberger, Xianwei Bu, Jianping Zhang, Shang Wang, Jinfeng Shi, Yu Hao, Jun Wu, Zeji Qiu, Yuh-Hai Wang, Chi-Jung Lou, Sam Watts, Peter Wayne, Gloria Vergara-Diaz, Brian Gow, Jose Miranda, Lewis Sudarsky, Eric Macklin, Kathrin Wode, Jenny Bergqvist, Britt-Marie Bernhardsson, Johanna Hök Nordberg, Lena Sharp, Roger Henriksson, Yeonju Woo, Min K. Hyun, Hao Wu, Tian-Fang Wang, Yan Zhao, Yu Wei, Lei Tian, Lei He, Xue Wang, Ruohan Wu, Mei Han, Patrina H. Y. Caldwell, Shigang Liu, Jing Zhang, Jianping Liu, Qianyun Chai, Zhongning Guo, Congcong Wang, Zhijun Liu, Xun Li, I. J. Yang, V. Ruberio Lincha, S. H. Ahn, D. U. Lee, H. M. Shin, Lu Yang, N. Yang, H. Sung, S. M. Shin, H. Y. Go, H. Jung, Y. Kim, T. Y. Park, Angela Yap, Yu H. Kwan, Chuen S. Tan, Syed Ibrahim, Seng B. Ang, Alfred Yayi, Jeong E. Yoo, Ho R. Yoo, Sae B. Jang, Hye L. Lee, Ala’a Youssef, Shahira Ezzat, Amira Abdel Motaal, Hesham El-Askary, Xiaotong Yu, Yashan Cui, Younghee Yun, Jin-Hyang Ahn, Bo-Hyung Jang, Kyu-Seok Kim, Inhwa Choi, Augustina Glinz, Fadime ten Brink, Arnd Büssing, Christoph Gutenbrunner, Bert Helbrecht, Tiesheng Fang, Fengxion Meng, Zhiming Shen, Ruixin Zhang, Fan Wu, Ming Li, Xinyun Xuan, Xueyong Shen, Ke Ren, Brian Berman, Zian Zheng, Yuxiang Wan, Xueyan Ma, Fei Dong, Suzie Zick, Richard Harris, Go E. Bae, Jung N. Kwon, Hye Y. Lee, Jong K. Nam, Sang D. Lee, Dong H. Lee, Ji Y. Han, Young J. Yun, Ji H. Lee, Hye L. Park, Seong H. Park, Chiara Bocci, Giovanni B. Ivaldi, Ilaria Vietti, Ilaria Meaglia, Marta Guffi, Rubina Ruggiero, Marita Gualea, Emanuela Longa, Massimo Bonucci, Sarah Croke, Lourdes Diaz Rodriguez, Juan C. Caracuel-Martínez, Manuel F. Fajardo-Rodríguez, Angélica Ariza-García, Francisca García-De la Fuente, Manuel Arroyo-Morales, Maria S. Estrems, Vicente G. Gómez, Mónica Valero Sabater, Rosaria Ferreri, Simonetta Bernardini, Roberto Pulcri, Franco Cracolici, Massimo Rinaldi, Claudio Porciani, Peter Fisher, John Hughes, Ariadna Mendoza, Hugh MacPherson, Jacqueline Filshie, Antonia Di Francesco, Alberto Bernardini, Monica Messe, Vincenzo Primitivo, Piera A. Iasella, Monica Taminato, Jaqueline Do Carmo Alcantara, Katia R. De Oliveira, Debora C. De Azevedo Rodrigues, Juliana R. Campana Mumme, Olga K. Matsumoto Sunakozawa, Vicente Odone Filho, Joshua Goldenberg, Andrew Day, Masa Sasagawa, Lesley Ward, Kieran Cooley, Thora Gunnarsdottir, Ingibjorg Hjaltadottir, Mahdie Hajimonfarednejad, Nicole Hannan, Rut Hellsing, Susanne Andermo, Maria Arman, Iris von Hörsten, Patricia Vásquez Torrielo, Carmen L. Andrade Vilaró, Francisco Cerda Cabrera, Henny Hui, Eric Ziea, Dora Tsui, Joyce Hsieh, Christine Lam, Edith Chan, Mark P. Jensen, Samuel L. Battalio, Joy Chan, Karlyn A. Edwards, Kevin J. Gertz, Melissa A. Day, Leslie H. Sherlin, Dawn M. Ehde, Bo-Hyoung Jang, Anja Börner, Jihong Lee, Boram Lee, Gyu T. Chang, Alejandra Menassa, Yoshiharu Motoo, Jürgen Müller, Sabine Rabini, Bettina Vinson, Martin Storr, Martin Niemeijer, Joop Hoekman, Wied Ruijssenaaars, Faith C. Njoku, Arne J. Norheim, Filiz Okumus, and Halime Oncu-Celik

Subjects
Other systems of medicine, RZ201-999
Published
2017
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8. Low fermentable, oligo-, di-, mono-saccharides and polyol diet in the treatment of irritable bowel syndrome: A systematic review and meta-analysis

Author

Dania Schumann, Holger Cramer, Gustav Dobos, Jost Langhorst, Romy Lauche, and Petra Klose

Subjects
medicine.medical_specialty, Abdominal pain, Polymers, Endocrinology, Diabetes and Metabolism, Medizin, Oligosaccharides, Cochrane Library, Disaccharides, Gastroenterology, law.invention, Irritable Bowel Syndrome, Diet, Carbohydrate-Restricted, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Humans, 030212 general & internal medicine, Adverse effect, Irritable bowel syndrome, Randomized Controlled Trials as Topic, chemistry.chemical_classification, Nutrition and Dietetics, Nutrition & Dietetics, business.industry, Monosaccharides, food and beverages, medicine.disease, Abdominal Pain, Gastrointestinal Microbiome, Gastrointestinal Tract, chemistry, Strictly standardized mean difference, Meta-analysis, Fermentation, Quality of Life, 030211 gastroenterology & hepatology, medicine.symptom, business, FODMAP
Abstract

Objectives The aim of this review was to systematically assess and meta-analyze the effects of a low fermentable, oligo-, di-, mono-saccharides and polyol (FODMAP) diet (LFD) on the severity of symptoms, quality of life, and safety in patients with irritable bowel syndrome (IBS). Methods The MEDLINE/PubMed, Scopus, and Cochrane Library databases were screened through January 19, 2016. Randomized controlled trials (RCTs) that compared LFD to other diets were included if they assessed symptoms of IBS or abdominal pain in patients with IBS. Safety, quality of life, anxiety, depression, and effect on gut microbiota were defined as secondary outcomes. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated. Results Nine RCTs with a total of 596 subjects were included. Three RCTs compared LFD with a habitual diet, two RCTs provided all meals and compared LFD with a western diet, one RCT each compared LFD with a diet high in FODMAPs or a sham diet, and two RCTs compared with other diet recommendations for IBS. A meta-analysis revealed significant group differences for LFD compared with other diets with regard to gastrointestinal symptoms (SMD = −0.62; 95% CI = −0.93 to −0.31; P = 0.0001), abdominal pain (SMD = −0.50; 95% CI = −0.77 to −0.22; P = 0.008), and health-related quality of life (SMD = 0.36; 95% CI = 0.10–0.62; P = 0.007). Three studies reported a significant reduction in luminal bifidobacteria after LFD. Adverse events were assessed in three RCTs only and no intervention-related adverse events were reported. Conclusions This meta-analysis found evidence of the short-term efficacy and safety of LFD in patients with IBS. However, only a preliminary recommendation for LFD can be made until long-term effects are investigated.

Published
2018

9. Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review

Author

Gustav Dobos, Holger Cramer, Dennis Anheyer, Romy Lauche, and Dania Schumann

Subjects
Complementary and Manual Therapy, medicine.medical_specialty, Valeriana officinalis, Adolescent, Herbal Medicine, Medizin, Alternative medicine, MEDLINE, Placebo, complex mixtures, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, 030225 pediatrics, Internal medicine, medicine, Humans, Attention deficit hyperactivity disorder, 030212 general & internal medicine, Child, Randomized Controlled Trials as Topic, Advanced and Specialized Nursing, Plants, Medicinal, Traditional medicine, business.industry, medicine.disease, Complementary and alternative medicine, Tolerability, Attention Deficit Disorder with Hyperactivity, Complementary & Alternative Medicine, Child, Preschool, Female, Melissa officinalis, business, Drugs, Chinese Herbal, Phytotherapy
Abstract

Objective The purpose of this review is to identify evidence in herbal therapy in the treatment of ADHD concerning effectiveness and drug tolerability. Method For this Medline/PubMed, Scopus and the Cochrane Central Register of Controlled Trials (Central) were searched from their inception to 15 July 2016. Only randomized controlled trails (RCT) with children (0–18years) suffering from ADHD were included in this review. Results Nine RCTs with 464 patients comparing herbal pharmaceuticals to placebo or active control were included. Seven different herbs were tested in the treatment of ADHD symptoms. Low evidence could be found for Melissa officinalis , Valeriana officinalis and Passiflora incarnata . Limited evidence could be found for pine bark extract and Gingko biloba. The other herbal preparations showed no efficacy in the treatment of ADHD symptoms. Conclusion While there is still a lack of sufficient numbers of RCTs no concrete recommendations for use can be made so far.

Published
2017

10. Qualitative study of yoga for Young adults in school sports

Author

Manuel Högl, Vijayendra Murthy, Holger C. Bringmann, Christian S. Kessler, Alexander Peters, Barbara Stöckigt, Georg Seifert, Andreas Michalsen, Michael Jeitler, and Dania Schumann

Subjects
Adult, Male, Complementary and Manual Therapy, medicine.medical_specialty, Adolescent, education, Pilot Projects, Context (language use), law.invention, Physical education, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Germany, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Students, Everyday life, Qualitative Research, Pain Measurement, Advanced and Specialized Nursing, Schools, business.industry, Yoga, Public health, Focus group, humanities, Distress, Complementary and alternative medicine, Female, business, human activities, Stress, Psychological, 030217 neurology & neurosurgery, Sports, Clinical psychology, Qualitative research
Abstract

Objectives Distress and stress-related diseases are an increasing public health problem at schools. This qualitative study was nested in a non-randomized, controlled trial studying the effects of a 10-week yoga course as an alternative for regular school sports in two secondary schools in Germany. Methods We conducted a qualitative evaluation in 3 focus groups with 6 participants each. The focus groups were audio-recorded, transcribed verbatim, pseudonymised and analysed using qualitative content analysis. Furthermore open questions were asked in questionnaires. Results The analysis of the participants’ interviews (mean age 19.6 ± 2.9 years, n = 10 female, n = 8 male) resulted in 4 key topics: 1. encountering yoga, 2. yoga practice, 3. effects and benefits of yoga, and 4. yoga in the school context. Yoga was very well accepted by most participants. They reported a variety of physical and psychological benefits as well as overall restorative effects. The relief of pain or other physical ailments, higher mobility and flexibility, improved posture and improved sleep were mentioned by the participants. Some participants used the new exercises and experiences (e.g. working with the breath) in their everyday life. The possibility for self-responsible action was a welcome change from the perceived pressure and heteronomy in normal (school) life. Controversial was the question of whether yoga - if it is part of school sport - should be assessed or graded, and whether it should be compulsory or voluntary. Conclusion Yoga can offer both physical and psychological benefits in young adults as well as offer general regenerative effects. Yoga by sensitizing the participants to negative patterns of behaviour can encourage healthy behaviour.

Published
2020

11. Yoga in school sport – A non-randomized controlled pilot study in Germany

Author

Dania Schumann, Andreas Michalsen, Wiebke Stritter, Christian S. Kessler, Alexander Peters, Nico Steckhan, Barbara Stöckigt, Manuel Högl, Michael Jeitler, Georg Seifert, and Hannah Zillgen

Subjects
Male, Complementary and Manual Therapy, medicine.medical_specialty, Randomization, Adolescent, Psychological intervention, Perceived Stress Scale, Pilot Projects, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Germany, Surveys and Questionnaires, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Young adult, Advanced and Specialized Nursing, Physical Education and Training, Schools, business.industry, Yoga, humanities, Distress, Mood, Complementary and alternative medicine, Quality of Life, Physical therapy, Anxiety, Female, medicine.symptom, business, human activities, Stress, Psychological, 030217 neurology & neurosurgery, Sports
Abstract

Objectives Distress is an increasing public health problem for adolescents and young adults. We aimed to evaluate potential effects of a 10-week 90-minute once-a-week yoga course. Methods A non-randomized controlled study with a school sport control group was implemented in two German secondary schools. Primary outcome was stress on the Perceived Stress Scale from baseline to week 10. Secondary outcomes included depression/anxiety, attention, quality of life, mood, visual analogue scales (for pain, headache, neck tension, exhaustion, sleep), and yoga-efficacy. Parameters were assessed at pre-baseline (before holidays), baseline (after 3-week holidays, before interventions started), week 10, and at a 6-months follow-up. An intention-to-treat analysis using ANCOVA was performed. Results 92 participants (67 % female; 19.6 ± 2.2 years) were included into the study. No significant differences were observed between the groups with regard to PSS, at either 10 weeks (Δ=-1.4; 95 % CI: -3.6;0.8; p = 0.22) or 6 months (Δ = 2; 95 % CI: -0.2;4.2, p = 0.08). Only VAS headache in favour of yoga and HADS-D in favour of school sport showed significant group differences at the 6-months follow-up. Significant intra-group mean changes for the primary outcome and several secondary outcomes were found in the yoga group. Conclusions Young adults in German secondary school settings might benefit from yoga, as the found effects were more prominent in the yoga group. However, the effects might be attributed to non-specific effects due to the chosen study design. Further studies are needed, which include high-quality study designs including randomization, longer-term follow-ups and larger sample sizes.

Published
2020

12. Yoga in Arterial Hypertension

Author

Holger Cramer, Gustav Dobos, Charlotte Sellin, and Dania Schumann

Subjects
Male, medicine.medical_specialty, media_common.quotation_subject, education, Physical Exertion, Blood Pressure, 030204 cardiovascular system & hematology, law.invention, Cardiovascular Physiological Phenomena, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Outcome Assessment, Health Care, Medicine, Humans, Meditation, Adverse effect, Wait list control group, media_common, Aged, business.industry, Respiration, Yoga, General Medicine, Blood Pressure Monitoring, Ambulatory, Middle Aged, Confidence interval, humanities, 030205 complementary & alternative medicine, Blood pressure, Ambulatory, Hypertension, Physical therapy, Breathing, Respiratory Physiological Phenomena, Female, Original Article, business, human activities
Abstract

Background Yoga seems to exert its effect against arterial hypertension mainly through the associated breathing and meditation techniques, and less so through yoga postures. The goal of this trial was to compare the blood pressure-lowering effect of yoga interventions with and without yoga postures in patients with arterial hypertension. Methods 75 patients taking medications for arterial hypertension (72% women, mean age 58.7 ± 9.5 years) were randomized into three groups: a yoga intervention group with yoga postures (25 patients, of whom 5 dropped out of the trial before its end), a yoga intervention group without yoga postures (25 patients, 3 dropouts), and a wait list control group (25 patients, one dropout). The interventions consisted of 90 minutes of yoga practice per week for twelve weeks. The data collectors, who were blinded to the intervention received, assessed the primary outcome measures "systolic 24-hour blood pressure" and "diastolic 24-hour blood pressure" before and after the intervention. In this report, we also present the findings on secondary outcome measures, including follow-up data. Results After the intervention, the systolic 24-hour blood pressure in the yoga intervention group without yoga postures was significantly lower than in the control group (group difference [Δ]= -3.8 mmHg; [95% confidence interval (CI): (-0.3; -7.4) p = 0.035]); it was also significantly lower than in the yoga intervention group with yoga postures (Δ = -3.2 mmHg; 95% CI: [-6.3; -0.8]; p = 0.045). Diastolic blood pressures did not differ significantly across groups. No serious adverse events were encountered in the course of the trial. Conclusion In accordance with the findings of earlier studies, we found that only yoga without yoga postures induced a short-term lowering of ambulatory systolic blood pressure. Yoga is safe and effective in patients taking medications for arterial hypertension and thus can be recommended as an additional treatment option for persons in this category.

Published
2018

13. Editorial: irritable bowel syndrome-in addition to having properly-trained dietitians, is it time to add a yoga teacher to our multidisciplinary team? Authors' reply

Author

Dania Schumann and Holger Cramer

Subjects
Patient Care Team, Patient care team, Hepatology, business.industry, media_common.quotation_subject, Yoga, Gastroenterology, MEDLINE, Multidisciplinary team, medicine.disease, Irritable Bowel Syndrome, 03 medical and health sciences, 0302 clinical medicine, Meditation, Nursing, 030220 oncology & carcinogenesis, medicine, Humans, 030211 gastroenterology & hepatology, Pharmacology (medical), Nutritionists, business, Irritable bowel syndrome, media_common
Published
2018

14. Letter: all or nothing - placebo effects in a non-drug clinical trial in IBS : Authors’ reply

Author

Dania Schumann and Holger Cramer

Subjects
Drug, medicine.medical_specialty, Hepatology, business.industry, Yoga, media_common.quotation_subject, Gastroenterology, Medizin, Placebo Effect, Placebo, Diet, Irritable Bowel Syndrome, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, Nothing, Internal medicine, medicine, Humans, 030211 gastroenterology & hepatology, Pharmacology (medical), 030212 general & internal medicine, business, media_common
Abstract

Korrespondenz zu 10.1111/apt.14400

Published
2018

15. Differences between vegetarian and omnivorous yoga practitioners: results of a nationally representative survey of US adult yoga practitioners

Author

Holger Cramer, Dania Schumann, Romy Lauche, Tobias Sundberg, Matthew J Leach, Cramer, Holger, Sundberg, Tobias, Schumann, Dania, Leach, Matthew J, and Lauche, Romy

Subjects
Complementary and Manual Therapy, Gerontology, Adult, Male, vegan, media_common.quotation_subject, Health Personnel, education, Medizin, Overweight, Logistic regression, Medizinische Fakultät » Universitätsklinikum Essen » Kliniken Essen-Mitte, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Health insurance, National Health Interview Survey, Medicine, Humans, 030212 general & internal medicine, Meditation, ddc:610, media_common, Aged, Advanced and Specialized Nursing, business.industry, Diet, Vegetarian, Yoga, vegetarian, Feeding Behavior, Middle Aged, humanities, 030205 complementary & alternative medicine, Cross-Sectional Studies, nutrition, Complementary and alternative medicine, yoga, Complementary & Alternative Medicine, Health complaint, Female, medicine.symptom, business, diet, human activities
Abstract

Background: To examine the prevalence of vegetarianism among yoga practitioners, and to explore differences and similarities between yoga practitioners who also use vegetarian diet and those who do not. Design and setting: Using cross-sectional data from the 2012 National Health Interview Survey (NHIS) (N = 34,525), weighted frequencies for 12-month prevalence of vegetarian diet use among yoga practitioners were analyzed. Logistic regression analyses were used to analyze sociodemographic and clinical predictors of vegetarian diet use. Results: A total of 1.7 million US yoga practitioners have used a vegetarian diet in the past 12 months (8.3%), compared to 2.7 million non-yoga practitioners (1.3%). Yoga practitioners who were aged between 30 and 64 years as compared to being 29 years or younger were more likely to have used a vegetarian diet in the past 12 months; while those being in a relationship (OR = 0.64), overweight (OR = 0.54), smoking (OR 0.64) or having private health insurance (OR = 0.59) were less likely. Vegetarian diet practitioners more often included meditation as part of their yoga practice and more often chose yoga because it had a holistic focus, and was perceived to treat the cause and not the symptoms of their health complaint. Conclusions: Yoga practitioners following a vegetarian diet seem to embrace yoga more as a lifestyle than as a therapy. Refereed/Peer-reviewed

Published
2018

16. Associations between yoga practice and joint problems : a cross-sectional survey among 9151 Australian women

Author

Romy Lauche, Dania Schumann, David Sibbritt, Holger Cramer, and Jon Adams

Subjects
musculoskeletal diseases, medicine.medical_specialty, Longitudinal study, Time Factors, Shoulders, Painful joints, Cross-sectional study, Immunology, education, Alternative medicine, Medizin, Logistic regression, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Risk Factors, medicine, Immunology and Allergy, Humans, Healthy Lifestyle, Range of Motion, Articular, Aged, 030222 orthopedics, Chi-Square Distribution, business.industry, Yoga, Australia, Middle Aged, Health Surveys, humanities, 030205 complementary & alternative medicine, Arthritis & Rheumatology, Biomechanical Phenomena, Logistic Models, Cross-Sectional Studies, Joint pain, Joint problems, Physical therapy, Joints, Female, medicine.symptom, Joint Diseases, business, human activities, Risk Reduction Behavior
Abstract

© 2017, Springer-Verlag Berlin Heidelberg. Yoga exercises have been associated with joint problems recently, indicating that yoga practice might be potentially dangerous for joint health. This study aimed to analyse whether regular yoga practice is associated with the frequency of joint problems in upper middle-aged Australian women. Women aged 62–67 years from the Australian Longitudinal Study on Women’s Health (ALSWH) were questioned in 2013 whether they experienced regular joint pain or problems in the past 12 months and whether they regularly practiced yoga. Associations of joint problems with yoga practice were analysed using Chi-squared tests and multiple logistic regression modelling. Of 9151 women, 29.8% reported regular problems with stiff or painful joints, and 15.2, 11.9, 18.1 and 15.9% reported regular problems with shoulders, hips, knees and feet, respectively, in the past 12 months. Yoga was practiced sometimes by 10.1% and often by 8.4% of women. Practicing yoga was not associated with upper or lower limb joint problems. No association between yoga practice and joint problems has been identified. Further studies are warranted for conclusive judgement of benefits and safety of yoga in relation to joint problems.

Published
2017

17. Letter: irritable bowel syndrome-how a low-FODMAP diet or yoga might help. Authors’ reply

Author

Holger Cramer and Dania Schumann

Subjects
medicine.medical_specialty, media_common.quotation_subject, Medizin, MEDLINE, Irritable Bowel Syndrome, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Pharmacology (medical), Meditation, Irritable bowel syndrome, media_common, Hepatology, business.industry, Yoga, Monosaccharides, Gastroenterology, medicine.disease, Diet, 030220 oncology & carcinogenesis, Low fodmap diet, 030211 gastroenterology & hepatology, business
Abstract

Korrespondenz zu 10.1111/apt.14433

Published
2018

18. Effect of Yoga in the Therapy of Irritable Bowel Syndrome : A Systematic Review

Author

Dennis Anheyer, Gustav Dobos, Jost Langhorst, Romy Lauche, Dania Schumann, and Holger Cramer

Subjects
medicine.medical_specialty, education, Medizin, Cochrane Library, law.invention, Mindfulness-based stress reduction, Irritable Bowel Syndrome, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Randomized controlled trial, law, Medicine, Humans, Irritable bowel syndrome, Randomized Controlled Trials as Topic, Gastroenterology & Hepatology, Hepatology, business.industry, Yoga, Gastroenterology, medicine.disease, Mood, Treatment Outcome, 030220 oncology & carcinogenesis, Adjunctive treatment, Physical therapy, Quality of Life, Anxiety, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

© 2016 AGA Institute Background & Aims This review aims to systematically survey the effects of yoga on symptoms of irritable bowel syndrome (IBS), pain, quality of life, mood, stress, and safety in patients with IBS. Methods MEDLINE/Pubmed, Scopus, the Cochrane Library, CAM-QUEST, CAMbase, and IndMED were screened through November 2015. Randomized controlled trials comparing yoga with usual care, nonpharmacologic, or pharmacologic interventions were analyzed for patients with IBS. Primary outcomes included gastrointestinal symptoms, quality of life, and pain. Anxiety, mood, and safety were defined as secondary outcomes. Risk of bias was assessed according to the Cochrane Collaboration recommendations. Results Six randomized controlled trials with a total of 273 patients were included in the qualitative analysis. There was evidence for a beneficial effect of a yogic intervention over conventional treatment in IBS, with significantly decreased bowel symptoms, IBS severity, and anxiety. Furthermore, there were significant improvements in quality of life, global improvement, and physical functioning after yoga compared with no treatment. Two randomized controlled trials reported safety data stating that no adverse events occurred. Overall, risk of bias of the included studies was unclear. Conclusions The findings of this systematic review suggest that yoga might be a feasible and safe adjunctive treatment for people with IBS. Nevertheless, no recommendation can be made regarding yoga as a routine intervention for patients with IBS because of major flaws in study methods. More research is needed with respect to a high-quality study design and consensus in clinical outcome measurements in IBS. ClinicalTrials.gov number, NCT02721836.

Published
2016

19. Characteristics of Americans Choosing Vegetarian and Vegan Diets for Health Reasons

Author

Jon Adams, Holger Cramer, Romy Lauche, Matthew J Leach, Christian S. Kessler, Tobias Sundberg, Dania Schumann, Cramer, Holger, Kessler, Christian S, Sundberg, Tobias, Leach, Matthew J, Schumann, Dania, Adams, Jon, and Lauche, Romy

Subjects
vegan, Adult, Male, 0301 basic medicine, Diet, Vegan, medicine.medical_specialty, Adolescent, Healthy Diet, prevalence, Population, Medizin, Alternative medicine, Medicine (miscellaneous), Overweight, Young Adult, 03 medical and health sciences, Diabetes mellitus, Environmental health, medicine, Health insurance, Humans, National Health Interview Survey, survey, education, Aged, Actual use, Sex Characteristics, education.field_of_study, 030109 nutrition & dietetics, Nutrition and Dietetics, Nutrition & Dietetics, business.industry, vegetarian, Diet, Vegetarian, Age Factors, Vegan Diet, Middle Aged, Nutrition Surveys, medicine.disease, United States, Cross-Sectional Studies, Female, Diet, Healthy, medicine.symptom, diet, business
Abstract

© 2017 Society for Nutrition Education and Behavior Objective Examine the prevalence, patterns, and associated factors of using a vegetarian or vegan diet for health reasons in the US general population. Design Cross-sectional data from the 2012 National Health Interview Survey. Participants Nationally representative sample (N = 34,525). Variables Measured Prevalence of ever use and 12-month use of vegetarian or vegan diet for health reasons, patterns of use, and sociodemographic and health-related factor associated with use. Analysis Multiple logistic regression analysis. Results Prevalence of ever use and 12-month use was 4.0% (n = 1,367) and 1.9% (n = 648), respectively. Health vegetarians and vegans were more likely aged 30–65 years, female, not Hispanic, from the Western US region, at least high school educated, chronically ill, and physically active. They were less likely to be in a relationship, overweight or obese, or smoking, or to have public or private health insurance. Among health vegetarians and vegans, 6.3% consulted with a practitioner for special diets; 26.1% followed the diet because of a specific health problem, mainly high cholesterol, overweight, hypertension, and diabetes; and 59.4% disclosed the diet to their health care provider. Conclusions and Implications Less than 2% of participants reported using a vegetarian or vegan diet for health reasons within the past 12 months. Despite potential benefits of plant-based nutrition, more research is warranted on the actual use and its effects and safety.

Published
2017

20. Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine

Author

Stefanie Hessel, Christoph Gottschalk, Dania Schumann, Alfonso Lampen, Angelika Preiss-Weigert, and Anja These

Subjects
ATP Binding Cassette Transporter, Subfamily B, Lumen (anatomy), Biological Availability, Biological Transport, Active, Biology, Asteraceae, Gastrointestinal epithelium, Madin Darby Canine Kidney Cells, Excretion, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Tandem Mass Spectrometry, Structure–activity relationship, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Pyrrolizidine Alkaloids, Plant Extracts, Biological Transport, Molecular biology, Bioavailability, Gastrointestinal Tract, chemistry, Biochemistry, Pyrrolizidine, Efflux, Caco-2 Cells, Senecionine, Food Science, Biotechnology, Chromatography, Liquid
Abstract

Scope: 1,2-Unsaturated pyrrolizidine alkaloids (PA) are found in plants such as Asteraceae and Boraginaceae families. Acute PA poisoning via contaminated food or feed causes severe damage to liver depending on species-specific oral bioavailability. For assessing PA bioavailability, their passage across the intestinal barrier was investigated using Caco-2 cells. Methods: Differentiated Caco-2 cells were exposed in transport chambers to the PA heliotrine (Hn), echimidine (Em), senecionine (Sc), and senkirkine (Sk). Cell supernatants were analyzed by LC-MS/MS. Results: PA pass Caco-2 monolayer from the apical into basolateral compartment depending on their chemical structure. Compared to the cyclic diesters Sc and Sk with a passage rate of 47%±4 and 40%±3, respectively, the transferred amount of the monoesterHn (32%±3) and open-chained diester Em(13% ± 2) was substantially lower. This suggested an active transport of Hn and Em. Using Madin–Darby canine kidney II/P-glycoprotein (ABCB1)-overexpressing cells, the active excretion of Hn and Em by ABCB1 from the gastrointestinal epithelium into the gut lumen was shown. Conclusion: PA cross the intestinal barrier structure-dependently. The passage of the noncyclic PA Hn and Emis reduced by an ABCB1-driven efflux into the gastrointestinal lumen resulting in a decreased oral bioavailability.

Published
2013

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