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509 results on '"Dani, Sourbha S."'

4. SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy-Related Cardiac Dysfunction.

Author

Avula, Vennela, Sharma, Garima, Kosiborod, Mikhail N, Vaduganathan, Muthiah, Neilan, Tomas G, Lopez, Teresa, Dent, Susan, Baldassarre, Lauren, Scherrer-Crosbie, Marielle, Barac, Ana, Liu, Jennifer, Deswal, Anita, Khadke, Sumanth, Yang, Eric H, Ky, Bonnie, Lenihan, Daniel, Nohria, Anju, Dani, Sourbha S, and Ganatra, Sarju

Abstract

Certain antineoplastic therapies are associated with an increased risk of cardiomyopathy and heart failure (HF). Sodium-glucose cotransporter-2 (SGLT2) inhibitors improve outcomes in patients with HF.This study aims to examine the efficacy of SGLT2 inhibitors in patients with cancer therapy-related cardiac dysfunction (CTRCD) or HF.The authors conducted a retrospective cohort analysis of deidentified, aggregate patient data from the TriNetX research network. Patients aged ≥18 years with a history of type 2 diabetes mellitus, cancer, and exposure to potentially cardiotoxic antineoplastic therapies, with a subsequent diagnosis of cardiomyopathy or HF between January 1, 2013, and April 30, 2020, were identified. Patients with ischemic heart disease were excluded. Patients receiving guideline-directed medical therapy were divided into 2 groups based on SGLT2 inhibitor use. After propensity score matching, odds ratios (ORs) and Cox proportional HRs were used to compare outcomes over a 2-year follow-up period.The study cohort included 1,280 patients with CTRCD/HF (n = 640 per group; mean age: 67.6 years; 41.6% female; 68% White). Patients on SGLT2 inhibitors in addition to conventional guideline-directed medical therapy had a lower risk of acute HF exacerbation (OR: 0.483 [95% CI: 0.36-0.65]; P < 0.001) and all-cause mortality (OR: 0.296 [95% CI: 0.22-0.40]; P = 0.001). All-cause hospitalizations or emergency department visits (OR: 0.479; 95% CI: 0.383-0.599; P < 0.001), atrial fibrillation/flutter (OR: 0.397 [95% CI: 0.213-0.737]; P = 0.003), acute kidney injury (OR: 0.486 [95% CI: 0.382-0.619]; P < 0.001), and need for renal replacement therapy (OR: 0.398 [95% CI: 0.189-0.839]; P = 0.012) were also less frequent in patients on SGLT2 inhibitors.SGLT2 inhibitor use is associated with improved outcomes in patients with CTRCD/HF.

Published
2023

5. Impact of Social Vulnerability on Comorbid Cancer and Cardiovascular Disease Mortality in the United States.

Author

Ganatra, Sarju, Dani, Sourbha S, Kumar, Ashish, Khan, Safi U, Wadhera, Rishi, Neilan, Tomas G, Thavendiranathan, Paaladinesh, Barac, Ana, Hermann, Joerg, Leja, Monika, Deswal, Anita, Fradley, Michael, Liu, Jennifer E, Sadler, Diego, Asnani, Aarti, Baldassarre, Lauren A, Gupta, Dipti, Yang, Eric, Guha, Avirup, Brown, Sherry-Ann, Stevens, Jennifer, Hayek, Salim S, Porter, Charles, Kalra, Ankur, Baron, Suzanne J, Ky, Bonnie, Virani, Salim S, Kazi, Dhruv, Nasir, Khurram, and Nohria, Anju

Abstract

Racial and social disparities exist in outcomes related to cancer and cardiovascular disease (CVD).The aim of this cross-sectional study was to study the impact of social vulnerability on mortality attributed to comorbid cancer and CVD.The Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database (2015-2019) was used to obtain county-level mortality data attributed to cancer, CVD, and comorbid cancer and CVD. County-level social vulnerability index (SVI) data (2014-2018) were obtained from the CDC's Agency for Toxic Substances and Disease Registry. SVI percentiles were generated for each county and aggregated to form SVI quartiles. Age-adjusted mortality rates (AAMRs) were estimated and compared across SVI quartiles to assess the impact of social vulnerability on mortality related to cancer, CVD, and comorbid cancer and CVD.The AAMR for comorbid cancer and CVD was 47.75 (95% CI: 47.66-47.85) per 100,000 person-years, with higher mortality in counties with greater social vulnerability. AAMRs for cancer and CVD were also significantly greater in counties with the highest SVIs. However, the proportional increase in mortality between the highest and lowest SVI counties was greater for comorbid cancer and CVD than for either cancer or CVD alone. Adults

Published
2022

10. Particulate Matter 2.5 Pollution Impact on Comorbid Cancer and Cardiovascular Disease Mortality in the U.S.

Author

Kumar, Ashish, Khadke, Sumanth, AlKindi, Sadeer, Rajagopalan, Sanjay, Nasir, Khurram, Kazi, Dhruv, Ahmad, Javaria, Khan, Safi, Asnani, Aarti, Addison, Daniel, Sadler, Diego, Deswal, Anita, Barac, Ana, Guha, Avirup, Liu, Jennifer, Lenihan, Daniel, Neilan, Tomas G., Hayek, Salim, Hermann, Joerg, Nohria, Anju, Dani, Sourbha S., and Ganatra, Sarju

Published
2024
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36. Association of Chronic Renal Insufficiency with Inhospital Outcomes in Primary Heart Failure Hospitalizations (Insights from the National Inpatient Sample 2004 to 2018)

Author

Minhas, Abdul Mannan Khan, Bhopalwala, Huzefa M., Dewaswala, Nakeya, Ijaz, Sardar Hassan, Khan, Muhammad Shahzeb, Khan, Muhammad Zia, Dani, Sourbha S., Warraich, Haider J., Greene, Stephen J., Edmonston, Daniel L., Lopez, Renato D., Virani, Salim S., Bhopalwala, Adnan, and Fudim, Marat

Published
2023
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39. Characteristics and outcomes in acute myocardial infarction hospitalizations among the older population (age ≥80 years) in the United States, 2004-2018

Author

Ijaz, Sardar Hassan, Minhas, Abdul Mannan Khan, Jain, Vardhmaan, Rifai, Mahmoud Al, Sharma, Garima, Mehta, Anurag, Dani, Sourbha S., Fudim, Marat, Al-Kindi, Sadeer G., Sperling, Laurence, Shapiro, Michael D., Alam, Mahboob, Virani, Salim S., Goel, Sachin S., Nasir, Khurram, and Khan, Safi U.

Published
2023
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42. Cardiovascular Diseases in the Patients With Psoriatic Arthritis

Author

Akhlaq, Anum, Ali, Huma Fatima, Sheikh, Abu Baker, Muhammad, Hafiz, Ijaz, Sardar Hassan, Sattar, Muhammad Hassaan, Nazir, Salik, Ud Din, Mian Tanveer, Nasir, Usama, Khan, Muhammad Zia, Muslim, Muhammad Osama, Wazir, Muhammad Hisham Khan, Dani, Sourbha S., Fudim, Marat, and Minhas, Abdul Mannan Khan

Published
2023
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