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1. The Management and Integration of Biomedical Knowledge: Application in the Health-e-Child Project (Position Paper)

Author

Jimenez-Ruiz, E., Berlanga, R., Sanz, I., McClatchey, R., Danger, R., Manset, D., Paraire, J., and Rios, A.

Subjects
Computer Science - Databases, H.2.4, J.3
Abstract

The Health-e-Child project aims to develop an integrated healthcare platform for European paediatrics. In order to achieve a comprehensive view of childrens health, a complex integration of biomedical data, information, and knowledge is necessary. Ontologies will be used to formally define this domain knowledge and will form the basis for the medical knowledge management system. This paper introduces an innovative methodology for the vertical integration of biomedical knowledge. This approach will be largely clinician-centered and will enable the definition of ontology fragments, connections between them (semantic bridges) and enriched ontology fragments (views). The strategy for the specification and capture of fragments, bridges and views is outlined with preliminary examples demonstrated in the collection of biomedical information from hospital databases, biomedical ontologies, and biomedical public databases., Comment: 6 pages; 2 figures. Proceedings of the 1st International Workshop on Ontology content and evaluation in Enterprise

Published
2006

4. T Cells Promote Bronchial Epithelial Cell Secretion of Matrix Metalloproteinase-9 via a C-C Chemokine Receptor Type 2 Pathway: Implications for Chronic Lung Allograft Dysfunction

Author

Pain, M., Royer, P.-J., Loy, J., Girardeau, A., Tissot, A., Lacoste, P., Roux, A., Reynaud-Gaubert, M., Kessler, R., Mussot, S., Dromer, C., Brugière, O., Mornex, J.-F., Guillemain, R., Dahan, M., Knoop, C., Botturi, K., Pison, C., Danger, R., Brouard, S., and Magnan, A.

Published
2017
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7. The Natural History of Clinical Operational Tolerance After Kidney Transplantation Through Twenty-Seven Cases

Author

Brouard, S., Pallier, A., Renaudin, K., Foucher, Y., Danger, R., Devys, A., Cesbron, A., Guillot-Guegen, C., Ashton-Chess, J., Le Roux, S., Harb, J., Roussey, G., Subra, J.-F., Villemain, F., Legendre, C., Bemelman, F.J., Orlando, G., Garnier, A., Jambon, H., Le Monies De Sagazan, H., Braun, L., Noël, C., Pillebout, E., Moal, M.-C., Cantarell, C., Hoitsma, A., Ranbant, M., Testa, A., Soulillou, J.-P., and Giral, M.

Published
2012
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15. Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution

Author

Trilleaud, C., primary, Gauttier, V., additional, Biteau, K., additional, Girault, I., additional, Belarif, L., additional, Mary, C., additional, Pengam, S., additional, Teppaz, G., additional, Thepenier, V., additional, Danger, R., additional, Robert-Siegwald, G., additional, Néel, M., additional, Bruneau, S., additional, Glémain, A., additional, Néel, A., additional, Poupon, A., additional, Mosnier, J. F., additional, Chêne, G., additional, Dubourdeau, M., additional, Blancho, G., additional, Vanhove, B., additional, and Poirier, N., additional

Published
2021
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21. COLT: Ten years of research in lung transplantation, results and perspectives

Author

Tissot, A., Foureau, A., Brosseau, C., Danger, R., Roux, A., Bernasconi, E., Gomez, C., Durand, M., Picard, B. R., Le Pavec, J., Claustre, J., Lacoste, P., Benmerad, M., Pain, M., Siroux, V., Royer, P. -J., Mordant, P., Reynaud-Gaubert, M., Kessler, R., Brugiere, O., Mornex, J. -F, Dromer, C., Dahan, M., Knoop, C., Boussaud, V., Koutsokera, A., Botturi-Cavailles, K., Durand, E., Loy, J., Nicod, L., Pison, C., Brouard, S., Blanc, F. -X., Magnan, A., Colt, Consortium, Immunoregulation And Immunointervention in Transplantation and Autoimmunity (Team 4 - U1064 Inserm - CRTI), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire d'étude des marériaux, Université de Brest (UBO), Service de pneumologie [Hôpital Foch], Hôpital Foch [Suresnes], CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pneumologie et Réanimation, Centre de reference de l'hypertension artérielle pulmonaire, Hôpital Antoine Béclère, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Sud (Paris 11), Dr SPOC, Paris, Center for Public Health Research (CSISP), University of Valencia, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de Pneumologie, Nouvel Hôpital Civil Strasbourg, CHU Bordeaux [Bordeaux], Ecole Nationale Supérieure de Chimie de Rennes (ENSCR), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Intervention, innovation, imagerie, ingénierie en santé - UFC (I4S), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), ANR-17-CE17-0008,Biket,Cellules B GZMB+, un facteur clé de l'immunité chez l'homme?(2017), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de transplantation pulmonaire [Hôpital Foch, Suresnes] (Pneumologie), Hôpital Foch [Suresnes]-Centre de fibrose kystique adulte [Hôpital Foch, Suresnes], Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut de Recherche pour le Développement (IRD [ Madagascar])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Ecole Nationale Supérieure de Chimie de Rennes, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Université Clermont Auvergne (UCA), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)

Subjects
Cohort Studies, Biomedical Research, Postoperative Complications, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Chronic Disease, Graft Survival, Humans, History, 20th Century, Primary Graft Dysfunction, History, 21st Century, ComputingMilieux_MISCELLANEOUS, Lung Transplantation
Abstract

National audience

Published
2018

22. IL-7 pathway controls human T cell homing to the gut and culminates in inflammatory bowel disease mucosa

Author

Belarif, Lyssia, Kermarec, L., Daguin, V., C., Mary, Danger, R., A., Kucik, Macdonald, T., Blancho, G., Naveilhan, P., Vanhove, Bernard, Poirier, Nicolas, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), OSE Immunotherapeutics [Nantes, France], Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Neuropathies du système nerveux entérique et pathologies digestives, implication des cellules gliales entériques, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Barts & The London School of Medicine and Dentistry [London, UK] (Blizard Institute), Queen Mary University of London (QMUL), and Le Bihan, Sylvie

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2017

23. Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome Appearance After Lung Transplantation

Author

Danger, R., Royer, Pierre-Joseph, Reboulleau, D., Loy, J., Tissot, A., Lacoste, P., Roux, A., Reynaud-Gaubert, M., Kessler, R., Mussot, S., Dromer, C., BrugiSre, O., Mornex, J., Guillemain, R., Dahan, M., Knoop, C., Botturi, K., Pison, C., Nicod, L., Brouard, S., Magnan, A., Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Service de Pneumologie, Nouvel Hôpital Civil Strasbourg, Clinique de pneumologie, CHU Grenoble, Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Intervention, innovation, imagerie, ingénierie en santé - UFC (I4S), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)

Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Abstract

American Transplant Congress, Chicago, IL, APR 29-MAY 03, 2017; International audience; no abstract

Published
2017

24. COLT : 10 ans de recherche en transplantation pulmonaire, résultats et perspectives

Author

Tissot, A., primary, Foureau, A., additional, Brosseau, C., additional, Danger, R., additional, Roux, A., additional, Bernasconi, E., additional, Gomez, C., additional, Durand, M., additional, Picard, B.R., additional, Le Pavec, J., additional, Claustre, J., additional, Lacoste, P., additional, Benmerad, M., additional, Pain, M., additional, Siroux, V., additional, Royer, P.-J., additional, Mordant, P., additional, Reynaud-Gaubert, M., additional, Kessler, R., additional, Brugière, O., additional, Mornex, J.-F., additional, Dromer, C., additional, Dahan, M., additional, Knoop, C., additional, Boussaud, V., additional, Koutsokera, A., additional, Botturi-Cavaillès, K., additional, Durand, E., additional, Loy, J., additional, Nicod, L., additional, Pison, C., additional, Brouard, S., additional, Blanc, F.-X., additional, and Magnan, A., additional

Published
2018
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27. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Author

Mouraux, Stéphane, primary, Bernasconi, Eric, additional, Pattaroni, Céline, additional, Koutsokera, Angela, additional, Aubert, John-David, additional, Claustre, Johanna, additional, Pison, Christophe, additional, Royer, Pierre-Joseph, additional, Magnan, Antoine, additional, Kessler, Romain, additional, Benden, Christian, additional, Soccal, Paola M., additional, Marsland, Benjamin J., additional, Nicod, Laurent P., additional, Jougon, J., additional, Velly, J.-F., additional, Rozé, H., additional, Blanchard, E., additional, Dromer, C., additional, Antoine, M., additional, Cappello, M., additional, Ruiz, M., additional, Sokolow, Y., additional, Vanden Eynden, F., additional, Van Nooten, G., additional, Barvais, L., additional, Berré, J., additional, Brimioulle, S., additional, De Backer, D., additional, Créteur, J., additional, Engelman, E., additional, Huybrechts, I., additional, Ickx, B., additional, Preiser, T.J.C., additional, Tuna, T., additional, Van Obberghe, L., additional, Vancutsem, N., additional, Vincent, J.-L., additional, De Vuyst, P., additional, Etienne, I., additional, Féry, F., additional, Jacobs, F., additional, Knoop, C., additional, Vachiéry, J.L., additional, Van den Borne, P., additional, Wellemans, I., additional, Amand, G., additional, Collignon, L., additional, Giroux, M., additional, Angelescu, D., additional, Chavanon, O., additional, Hacini, R., additional, Pirvu, A., additional, Porcu, P., additional, Albaladejo, P., additional, Allègre, C., additional, Bataillard, A., additional, Bedague, D., additional, Briot, E., additional, Casez-Brasseur, M., additional, Colas, D., additional, Dessertaine, G., additional, Durand, M., additional, Francony, G., additional, Hebrard, A., additional, Marino, M.R., additional, Oummahan, B., additional, Protar, D., additional, Rehm, D., additional, Robin, S., additional, Rossi-Blancher, M., additional, Augier, C., additional, Bedouch, P., additional, Boignard, A., additional, Bouvaist, H., additional, Briault, A., additional, Camara, B., additional, Claustre, J., additional, Chanoine, S., additional, Dubuc, M., additional, Quétant, S., additional, Maurizi, J., additional, Pavèse, P., additional, Pison, C., additional, Saint-Raymond, C., additional, Wion, N., additional, Chérion, C., additional, Grima, R., additional, Jegaden, O., additional, Maury, J.-M., additional, Tronc, F., additional, Flamens, C., additional, Paulus, S., additional, Mornex, J.-F., additional, Philit, F., additional, Senechal, A., additional, Glérant, J.-C., additional, Turquier, S., additional, Gamondes, D., additional, Chalabresse, L., additional, Thivolet-Bejui, F., additional, Barnel, C., additional, Dubois, C., additional, Tiberghien, A., additional, Le Pimpec-Barthes, F., additional, Bel, A., additional, Mordant, P., additional, Achouh, P., additional, Boussaud, V., additional, Guillemain, R., additional, Méléard, D., additional, Bricourt, M.O., additional, Cholley, B., additional, Pezella, V., additional, Brioude, G., additional, D'Journo, X.B., additional, Doddoli, C., additional, Thomas, P., additional, Trousse, D., additional, Dizier, S., additional, Leone, M., additional, Papazian, L., additional, Bregeon, F., additional, Basire, A., additional, Coltey, B., additional, Dufeu, N., additional, Dutau, H., additional, Garcia, S., additional, Gaubert, J.Y., additional, Gomez, C., additional, Laroumagne, S., additional, Nieves, A., additional, Picard, L.C., additional, Reynaud-Gaubert, M., additional, Secq, V., additional, Mouton, G., additional, Baron, O., additional, Lacoste, P., additional, Perigaud, C., additional, Roussel, J.C., additional, Danner, I., additional, Haloun, A., additional, Magnan, A., additional, Tissot, A., additional, Lepoivre, T., additional, Treilhaud, M., additional, Botturi-Cavaillès, K., additional, Brouard, S., additional, Danger, R., additional, Loy, J., additional, Morisset, M., additional, Pain, M., additional, Pares, S., additional, Reboulleau, D., additional, Royer, P.-J., additional, Fabre, D., additional, Fadel, E., additional, Mercier, O., additional, Mussot, S., additional, Stephan, F., additional, Viard, P., additional, Cerrina, J., additional, Dorfmuller, P., additional, Ghigna, S.M., additional, Hervén, Ph., additional, Le Roy Ladurie, F., additional, Le Pavec, J., additional, Thomas de Montpreville, V., additional, Lamrani, L., additional, Castier, Y., additional, Cerceau, P., additional, Augustin, P., additional, Jean-Baptiste, S., additional, Boudinet, S., additional, Montravers, P., additional, Brugière, O., additional, Dauriat, G., additional, Jébrak, G., additional, Mal, H., additional, Marceau, A., additional, Métivier, A.-C., additional, Thabut, G., additional, Lhuillier, E., additional, Dupin, C., additional, Bunel, V., additional, Falcoz, P., additional, Massard, G., additional, Santelmo, N., additional, Ajob, G., additional, Collange, O., additional, Helms, O., additional, Hentz, J., additional, Roche, A., additional, Bakouboula, B., additional, Degot, T., additional, Dory, A., additional, Hirschi, S., additional, Ohlmann-Caillard, S., additional, Kessler, L., additional, Kessler, R., additional, Schuller, A., additional, Bennedif, K., additional, Vargas, S., additional, Stauder, J., additional, Ali-Azouaou, S., additional, Bonnette, P., additional, Chapelier, A., additional, Puyo, P., additional, Sage, E., additional, Bresson, J., additional, Caille, V., additional, Cerf, C., additional, Devaquet, J., additional, Dumans-Nizard, V., additional, Felten, M.-L., additional, Fischler, M., additional, Si Larbi, A.-G., additional, Leguen, M., additional, Ley, L., additional, Liu, N., additional, Trebbia, G., additional, De Miranda, S., additional, Douvry, B., additional, Gonin, F., additional, Grenet, D., additional, Hamid, A.M., additional, Neveu, H., additional, Parquin, F., additional, Picard, C., additional, Roux, A., additional, Stern, M., additional, Bouillioud, F., additional, Cahen, P., additional, Colombat, M., additional, Dautricourt, C., additional, Delahousse, M., additional, D'Urso, B., additional, Gravisse, J., additional, Guth, A., additional, Hillaire, S., additional, Honderlick, P., additional, Lequintrec, M., additional, Longchampt, E., additional, Mellot, F., additional, Scherrer, A., additional, Temagoult, L., additional, Tricot, L., additional, Vasse, M., additional, Veyrie, C., additional, Zemoura, L., additional, Berjaud, J., additional, Brouchet, L., additional, Dahan, M., additional, Mathe, F.O., additional, Benahoua, H., additional, DaCosta, M., additional, Serres, I., additional, Merlet-Dupuy, V., additional, Grigoli, M., additional, Didier, A., additional, Murris, M., additional, Crognier, L., additional, Fourcade, O., additional, Krueger, T., additional, Ris, H.B., additional, Gonzalez, M., additional, Jolliet, Ph., additional, Marcucci, C., additional, Chollet, M., additional, Gronchi, F., additional, Courbon, C., additional, Berutto, C., additional, Manuel, O., additional, Koutsokera, A., additional, Aubert, J.-D., additional, Nicod, L.P., additional, Mouraux, S., additional, Bernasconi, E., additional, Pattaroni, C., additional, Marsland, B.J., additional, Soccal, P.M., additional, Rochat, T., additional, Lücker, L.M., additional, Hillinger, S., additional, Inci, I., additional, Weder, W., additional, Schuepbach, R., additional, Zalunardo, M., additional, Benden, C., additional, Schuurmans, M.M., additional, Gaspert, A., additional, Holzmann, D., additional, Müller, N., additional, Schmid, C., additional, Vrugt, B., additional, Fritz, A., additional, Maier, D., additional, Deplanche, K., additional, Koubi, D., additional, Ernst, F., additional, Paprotka, T., additional, Schmitt, M., additional, Wahl, B., additional, Boissel, J.-P., additional, Olivera-Botello, G., additional, Trocmé, C., additional, Toussaint, B., additional, Bourgoin-Voillard, S., additional, Sève, M., additional, Benmerad, M., additional, Siroux, V., additional, Slama, R., additional, Auffray, C., additional, Charron, D., additional, Lefaudeux, D., additional, and Pellet, J., additional

Published
2018
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28. Hepatocyte-Related miR-193a-3p Is Over-Expressed in Allograft Biopsy from Liver Tolerant Recipients

Author

King's College, London - MRC Transplant Centre, Danger, R, Lozano, J, Bonaccorsi Riani, Eliano, Kodela, E, Mas-Malavila, R, Londono, M.C, Martinez, M, Rimola, A, Martinez-Llordellla, M, Sanchez-Fueyo, A, 15th American Transplant Congress, ATC 2015, King's College, London - MRC Transplant Centre, Danger, R, Lozano, J, Bonaccorsi Riani, Eliano, Kodela, E, Mas-Malavila, R, Londono, M.C, Martinez, M, Rimola, A, Martinez-Llordellla, M, Sanchez-Fueyo, A, and 15th American Transplant Congress, ATC 2015

Abstract

While liver transplantation is the treatment of choice for end-stage liver diseases, its success is compromised by the need to administer life-long immunosuppression, which negatively impacts on long-term outcomes. This emphasizes the need for the identification of biomarkers of successful immunosuppression (IS) withdrawal (operational tolerance). Our research group has pioneered the use of molecular profiling tools to characterize IS-free tolerant liver recipients. Thus, we recently completed a multi-centre IS withdrawal trial that included 102 liver recipients, 41 of whom achieved a successful drug discontinuation (TOL) and 57 rejected (Non-TOL). To understand the influence of miRNA regulation in the establishment of liver allograft tolerance, we collected liver biopsies before IS withdrawal was initiated and analyzed miRNA expression by small RNA sequencing. Employing a training set comprising liver biopsies from 12 TOL and 10 Non-TOL hepatitis C (HCV)-negative recipients, we identified 9 differential miRNAs out of 1,033 expressed human mature miRNAs (FC>1.5, p<0.05). The expression of these 9 miRNAs could discriminate TOL from Non-TOL recipients when employing principal component analysis. The differential expression of the most informative miRNA, miR-193a-3p, was confirmed by qPCR in an independent set of 14 TOL and 14 Non-TOL. miR-193a-3p was significantly over-expressed in TOL samples (p=0.011, fold change= 2.98) and exhibited a high predictive value with a ROC AUC of 0.79 (p=0.010). Thus, the use of a sole miRNA could be useful in the prediction of IS withdrawal outcome. Furthermore, we found miR-193a-3p is highly expressed in enriched hepatocytes compared to liver mononuclear cells or peripheral blood cells. Given a previously reported association between miR-193a-3p down-regulation and acetaminophen overdose-induced injury, we hypothesize that miR-193a-3p over-expression in tolerant patients protects hepatocytes from tissue damages elicited by IS withdrawa

Published
2015

37. P890 SPECIFIC PHENOTYPE AND GENE EXPRESSION PROFILES OF COMBINED LIVER AND KIDNEY TRANSPLANTED PATIENTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS

Author

Dumontet, E., primary, Danger, R., additional, Vagefi, P., additional, Londoño, M.-C., additional, Pallier, A., additional, Lozano, J.J., additional, Giral, M., additional, Degauque, N., additional, Martínez-Llordella, M., additional, Latournerie, M., additional, Boudjéma, K., additional, Dulong, J., additional, Tarte, K., additional, Soulillou, J.-P., additional, Sanchez-Fueyo, A., additional, Feng, S., additional, Brouard, S., additional, and Conchon, S., additional

Published
2014
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45. The Management and Integration of Biomedical Knowledge: Application in the Health-e-Child Project (Position Paper).

Author

Meersman, Robert, Tari, Zahir, Herrero, Pilar, Jimenez-Ruiz, E., Berlanga, R., Sanz, I., McClatchey, R., Danger, R., Manset, D., Paraire, J., and Rios, A.

Abstract

The Health-e-Child project aims to develop an integrated healthcare platform for European paediatrics. In order to achieve a comprehensive view of children's health, a complex integration of biomedical data, information, and knowledge is necessary. Ontologies will be used to formally define this domain knowledge and will form the basis for the medical knowledge management system. This paper introduces an innovative methodology for the vertical integration of biomedical knowledge. This approach will be largely clinician-centered and will enable the definition of ontology fragments, connections between them (semantic bridges) and enriched ontology fragments (views). The strategy for the specification and capture of fragments, bridges and views is outlined with preliminary examples demonstrated in the collection of biomedical information from hospital databases, biomedical ontologies, and biomedical public databases. Keywords: Vertical Knowledge Integration, Approximate Queries, Ontology Views, Semantic Bridges. [ABSTRACT FROM AUTHOR]

Published
2006
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49. Rise of a CD27 - IgD - CD11c + B cells population in kidney recipients achieving long-term graft stability under immunosuppression.

Author

Brinas F, Sailliet N, Tilly G, Delbos L, Kerleau C, Giral M, Degauque N, Brouard S, and Danger R

Abstract

The use of immunosuppressive treatment is required to prevent rejection events, even a long time after kidney transplantation despite rare recipients achieving long-term graft stability without the need for immunosuppressive treatment, called operationally tolerant patients (TOLs). We comprehensively investigate the immune system of long-term IS recipients (LTTs) and TOLs to highlight their shared and unique immune features. Blood immune cell phenotyping was performed by spectral cytometry. Samples from 34 individuals were analyzed, including 6 LTTs, 8 TOLs, 10 stable patients at 1 year posttransplantation (STAs), and 10 healthy volunteers. B cells differed between LTTs and TOLs with a decreased total B-cell frequency and the acquisition of a memory phenotype in LTTs whereas a naive phenotype is maintained in TOLs. The frequencies of IgD - CD27 - B cells and CD11c + memory B cells are increased in LTTs, with an exhausted phenotype, evoked by a significant decrease in CD25 expression. These CD11c + B cells display an exhausted phenotype similar to those found in several chronic immune diseases in which they have been shown to participate in their pathophysiology, suggesting active chronic inflammation in LTTs. Altogether, these data indicate that precautions should be taken to minimize IS use., (© 2024 The Author(s). European Journal of Immunology published by Wiley‐VCH GmbH.)

Published
2024
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50. Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN).

Author

Goutaudier V, Danger R, Catar RA, Racapé M, Philippe A, Elias M, Raynaud M, Aubert O, Bouton D, Girardin F, Vicaut É, Yaiche S, Demotes J, Heidecke H, Taupin JL, Randoux-Lebrun C, Zaidan M, Papuchon E, Le Mai H, Nguyen TV, Moreso F, Berney T, Villard J, Legendre C, Dragun D, Papalois V, Potena L, Giral M, Gourraud PA, Brouard S, Crespo E, Halleck F, Budde K, Bestard O, Loupy A, and Lefaucheur C

Subjects
Humans, Prospective Studies, Male, Female, Middle Aged, Adult, Europe, Isoantibodies blood, Isoantibodies immunology, Aged, Allografts immunology, Biopsy, Graft Rejection immunology, Graft Rejection blood, Graft Rejection diagnosis, Kidney Transplantation adverse effects, Biomarkers blood, HLA Antigens immunology, HLA Antigens blood, HLA Antigens genetics
Abstract

Non-invasive biomarkers are promising tools for improving kidney allograft rejection monitoring, but their clinical adoption requires more evidence in specifically designed studies. To address this unmet need, we designed the EU-TRAIN study, a large prospective multicentric unselected cohort funded by the European Commission. Here, we included consecutive adult patients who received a kidney allograft in nine European transplant centers between November 2018 and June 2020. We prospectively assessed gene expression levels of 19 blood messenger RNAs, four antibodies targeting non-human leukocyte antigen (HLA) endothelial antigens, together with circulating anti-HLA donor-specific antibodies (DSA). The primary outcome was allograft rejection (antibody-mediated, T cell-mediated, or mixed) in the first year post-transplantation. Overall, 412 patients were included, with 812 biopsies paired with a blood sample. CD4 gene expression was significantly associated with rejection, while circulating anti-HLA DSA had a significant association with allograft rejection and a strong association with antibody-mediated rejection. All other tested biomarkers, including AKR1C3, CD3E, CD40, CD8A, CD9, CTLA4, ENTPD1, FOXP3, GZMB, ID3, IL7R, MS4A1, MZB1, POU2AF1, POU2F1, TCL1A, TLR4, and TRIB1, as well as antibodies against angiotensin II type 1 receptor, endothelin 1 type A receptor, C3a and C5a receptors, did not show significant associations with allograft rejection. The blood messenger RNAs and non-HLA antibodies did not show an additional value beyond standard of care monitoring parameters and circulating anti-HLA DSA to predict allograft rejection in the first year post-transplantation. Thus, our results open avenues for specifically designed studies to demonstrate the clinical relevance and implementation of other candidate non-invasive biomarkers in kidney transplantation practice., (Copyright © 2024 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)

Published
2024
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