Search

Your search keyword '"Dang, Ha X."' showing total 157 results
Start Over Author "Dang, Ha X."
157 results on '"Dang, Ha X."'

2. Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions

Author

Ballet, Romain, LaJevic, Melissa, Huskey-Mullin, Noelle, Roach, Rachel, Brulois, Kevin, Huang, Ying, Saeed, Muhammad A, Dang, Ha X, Pachynski, Russell K, Wilson, Elizabeth, Butcher, Eugene C, and Zabel, Brian A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Prostate Cancer, Urologic Diseases, 2.1 Biological and endogenous factors, Aetiology, Humans, Animals, Mice, CD8-Positive T-Lymphocytes, Receptors, CCR7, T-Lymphocyte Subsets, Killer Cells, Natural, Neoplasms, Chemokines, Tumor Microenvironment, Intercellular Signaling Peptides and Proteins, CMKLR1, T cell trafficking, chemerin, chemoattractant, immune oncology, integrin, Biological Sciences, Technology, Medical and Health Sciences, Biotechnology, Genetics, Clinical sciences, Medical biotechnology
Abstract

The recruitment of cells with effector functions into the tumor microenvironment holds potential for delaying cancer progression. We show that subsets of human CD28-effector CD8 T cells, CCR7- CD45RO+ effector memory, and CCR7- CD45RO- effector memory RA phenotypes, express the chemerin receptor CMKLR1 and bind chemerin via the receptor. CMKLR1-expressing human CD8 effector memory T cells present gene, protein, and cytotoxic features of NK cells. Active chemerin promotes chemotaxis of CMKLR1-expressing CD8 effector memory cells and triggers activation of the α4β1 integrin. In an experimental prostate tumor mouse model, chemerin expression is downregulated in the tumor microenvironment, which is associated with few tumor-infiltrating CD8+ T cells, while forced overexpression of chemerin by mouse prostate cancer cells leads to an accumulation of intra-tumor CD8+ T cells. Furthermore, α4 integrin blockade abrogated the chemerin-dependent recruitment of CD8+ T effector memory cells into implanted prostate tumors in vivo. The results identify a role for chemerin:CMKLR1 in defining a specialized NK-like CD8 T cell, and suggest the use of chemerin-dependent modalities to target effector CMKLR1-expressing T cells to the tumor microenvironment for immunotherapeutic purposes.

Published
2023

4. The DNA methylation landscape of advanced prostate cancer

Author

Zhao, Shuang G, Chen, William S, Li, Haolong, Foye, Adam, Zhang, Meng, Sjöström, Martin, Aggarwal, Rahul, Playdle, Denise, Liao, Arnold, Alumkal, Joshi J, Das, Rajdeep, Chou, Jonathan, Hua, Junjie T, Barnard, Travis J, Bailey, Adina M, Chow, Eric D, Perry, Marc D, Dang, Ha X, Yang, Rendong, Moussavi-Baygi, Ruhollah, Zhang, Li, Alshalalfa, Mohammed, Laura Chang, S, Houlahan, Kathleen E, Shiah, Yu-Jia, Beer, Tomasz M, Thomas, George, Chi, Kim N, Gleave, Martin, Zoubeidi, Amina, Reiter, Robert E, Rettig, Matthew B, Witte, Owen, Yvonne Kim, M, Fong, Lawrence, Spratt, Daniel E, Morgan, Todd M, Bose, Rohit, Huang, Franklin W, Li, Hui, Chesner, Lisa, Shenoy, Tanushree, Goodarzi, Hani, Asangani, Irfan A, Sandhu, Shahneen, Lang, Joshua M, Mahajan, Nupam P, Lara, Primo N, Evans, Christopher P, Febbo, Phillip, Batzoglou, Serafim, Knudsen, Karen E, He, Housheng H, Huang, Jiaoti, Zwart, Wilbert, Costello, Joseph F, Luo, Jianhua, Tomlins, Scott A, Wyatt, Alexander W, Dehm, Scott M, Ashworth, Alan, Gilbert, Luke A, Boutros, Paul C, Farh, Kyle, Chinnaiyan, Arul M, Maher, Christopher A, Small, Eric J, Quigley, David A, and Feng, Felix Y

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Genetics, Cancer, Prostate Cancer, Human Genome, Urologic Diseases, Cancer Genomics, Biotechnology, 2.1 Biological and endogenous factors, Aged, Aged, 80 and over, Carcinogenesis, DNA Methylation, Epigenomics, Gene Expression Regulation, Neoplastic, Genome, Humans, Male, Middle Aged, Mutation, Prospective Studies, Prostatic Neoplasms, Sequence Analysis, DNA, Exome Sequencing, Whole Genome Sequencing, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 100 castration-resistant prostate metastases, we discovered alterations affecting driver genes that were detectable only with integrated whole-genome approaches. Notably, we observed that 22% of tumors exhibited a novel epigenomic subtype associated with hypermethylation and somatic mutations in TET2, DNMT3B, IDH1 and BRAF. We also identified intergenic regions where methylation is associated with RNA expression of the oncogenic driver genes AR, MYC and ERG. Finally, we showed that differential methylation during progression preferentially occurs at somatic mutational hotspots and putative regulatory regions. This study is a large integrated study of whole-genome, whole-methylome and whole-transcriptome sequencing in metastatic cancer that provides a comprehensive overview of the important regulatory role of methylation in metastatic castration-resistant prostate cancer.

Published
2020

5. Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, Yang, Rendong, Henzler, Christine M, Ho, Yeung, Passow, Courtney, Auch, Benjamin, Carreira, Suzanne, Rodrigues, Daniel Nava, Bertan, Claudia, Hwang, Tae Hyun, Quigley, David A, Dang, Ha X, Morrissey, Colm, Fraser, Michael, Plymate, Stephen R, Maher, Christopher A, Feng, Felix Y, de Bono, Johann S, and Dehm, Scott M

Subjects
Urologic Diseases, Prostate Cancer, Aging, Biotechnology, Cancer, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Androgen Receptor Antagonists, Benzamides, Biomarkers, Tumor, Cell Line, Tumor, Drug Resistance, Neoplasm, Gene Rearrangement, Humans, Male, Neoplasm Metastasis, Nitriles, Phenylthiohydantoin, Prospective Studies, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, Whole Genome Sequencing, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeProstate cancer is the second leading cause of male cancer deaths. Castration-resistant prostate cancer (CRPC) is a lethal stage of the disease that emerges when endocrine therapies are no longer effective at suppressing activity of the androgen receptor (AR) transcription factor. The purpose of this study was to identify genomic mechanisms that contribute to the development and progression of CRPC.Experimental designWe used whole-genome and targeted DNA-sequencing approaches to identify mechanisms underlying CRPC in an aggregate cohort of 272 prostate cancer patients. We analyzed structural rearrangements at the genome-wide level and carried out a detailed structural rearrangement analysis of the AR locus. We used genome engineering to perform experimental modeling of AR gene rearrangements and long-read RNA sequencing to analyze effects on expression of AR and truncated AR variants (AR-V).ResultsAR was among the most frequently rearranged genes in CRPC tumors. AR gene rearrangements promoted expression of diverse AR-V species. AR gene rearrangements occurring in the context of AR amplification correlated with AR overexpression. Cell lines with experimentally derived AR gene rearrangements displayed high expression of tumor-specific AR-Vs and were resistant to endocrine therapies, including the AR antagonist enzalutamide.ConclusionsAR gene rearrangements are an important mechanism of resistance to endocrine therapies in CRPC.

Published
2020

7. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Author

Quigley, David A, Dang, Ha X, Zhao, Shuang G, Lloyd, Paul, Aggarwal, Rahul, Alumkal, Joshi J, Foye, Adam, Kothari, Vishal, Perry, Marc D, Bailey, Adina M, Playdle, Denise, Barnard, Travis J, Zhang, Li, Zhang, Jin, Youngren, Jack F, Cieslik, Marcin P, Parolia, Abhijit, Beer, Tomasz M, Thomas, George, Chi, Kim N, Gleave, Martin, Lack, Nathan A, Zoubeidi, Amina, Reiter, Robert E, Rettig, Matthew B, Witte, Owen, Ryan, Charles J, Fong, Lawrence, Kim, Won, Friedlander, Terence, Chou, Jonathan, Li, Haolong, Das, Rajdeep, Li, Hui, Moussavi-Baygi, Ruhollah, Goodarzi, Hani, Gilbert, Luke A, Lara, Primo N, Evans, Christopher P, Goldstein, Theodore C, Stuart, Joshua M, Tomlins, Scott A, Spratt, Daniel E, Cheetham, R Keira, Cheng, Donavan T, Farh, Kyle, Gehring, Julian S, Hakenberg, Jörg, Liao, Arnold, Febbo, Philip G, Shon, John, Sickler, Brad, Batzoglou, Serafim, Knudsen, Karen E, He, Housheng H, Huang, Jiaoti, Wyatt, Alexander W, Dehm, Scott M, Ashworth, Alan, Chinnaiyan, Arul M, Maher, Christopher A, Small, Eric J, and Feng, Felix Y

Subjects
Humans, Prostatic Neoplasms, Neoplasm Metastasis, Cyclin-Dependent Kinases, Proto-Oncogene Proteins c-myc, BRCA2 Protein, Receptors, Androgen, Gene Expression Profiling, Genomics, Tandem Repeat Sequences, Mutation, Aged, Aged, 80 and over, Middle Aged, Male, Tumor Suppressor Protein p53, Genomic Structural Variation, DNA Copy Number Variations, Exome, Whole Genome Sequencing, BRCA2, androgen receptor, castration resistant prostate cancer, chromothripsis, gene fusion, genomics, metastases, structural variation, tandem duplication, whole-genome sequencing, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we identified structural variants altering critical regulators of tumorigenesis and progression not detectable by exome approaches. Notably, we observed amplification of an intergenic enhancer region 624 kb upstream of the androgen receptor (AR) in 81% of patients, correlating with increased AR expression. Tandem duplication hotspots also occur near MYC, in lncRNAs associated with post-translational MYC regulation. Classes of structural variations were linked to distinct DNA repair deficiencies, suggesting their etiology, including associations of CDK12 mutation with tandem duplications, TP53 inactivation with inverted rearrangements and chromothripsis, and BRCA2 inactivation with deletions. Together, these observations provide a comprehensive view of how structural variations affect critical regulators in metastatic prostate cancer.

Published
2018

10. Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival inAR-altered lethal prostate cancer

Author

Chauhan, Pradeep S., primary, Alahi, Irfan, additional, Sinha, Savar, additional, Shiang, Alexander L., additional, Mueller, Ryan, additional, Webster, Jace, additional, Dang, Ha X., additional, Saha, Debanjan, additional, Greiner, Lilli, additional, Yang, Breanna, additional, Ni, Gabris, additional, Ledet, Elisa M., additional, Babbra, Ramandeep K., additional, Feng, Wenjia, additional, Harris, Peter K., additional, Qaium, Faridi, additional, Jaeger, Ellen B., additional, Miller, Patrick J., additional, Caputo, Sydney A., additional, Sartor, Oliver, additional, Pachynski, Russell K., additional, Maher, Christopher A., additional, and Chaudhuri, Aadel A., additional

Published
2023
Full Text
View/download PDF

12. PACT: A pipeline for analysis of circulating tumor DNA

Author

Webster, Jace, primary, Dang, Ha X, additional, Chauhan, Pradeep S, additional, Feng, Wenjia, additional, Shiang, Alex, additional, Harris, Peter K, additional, Pachynski, Russell K, additional, Chaudhuri, Aadel A, additional, and Maher, Christopher A, additional

Published
2023
Full Text
View/download PDF

13. Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes

Author

Zhang, Jin, Griffith, Malachi, Miller, Christopher A., Griffith, Obi L., Spencer, David H., Walker, Jason R., Magrini, Vincent, McGrath, Sean D., Ly, Amy, Helton, Nichole M., Trissal, Maria, Link, Daniel C., Dang, Ha X., Larson, David E., Kulkarni, Shashikant, Cordes, Matthew G., Fronick, Catrina C., Fulton, Robert S., Klco, Jeffery M., Mardis, Elaine R., Ley, Timothy J., Wilson, Richard K., and Maher, Christopher A.

Published
2017
Full Text
View/download PDF

14. Abstract 6698: Combinatorial genomic and epigenomic cell-free DNA analysis of high-risk metastatic castration resistant prostate cancer reveals prognostic liquid biopsy signatures

Author

Alahi, Irfan, primary, Chauhan, Pradeep S., additional, Shiang, Alexander L., additional, Webster, Jace, additional, Dang, Ha X., additional, Greiner, Lilli, additional, yang, Breanna, additional, Ledet, Elisa M., additional, Babbra, Ramandeep K., additional, Feng, Wenjia, additional, Harris, Peter K., additional, Jaeger, Ellen B., additional, Miller, Patrick J., additional, Caputo, Sydney A., additional, Santos, Giordano Cittolin, additional, Sartor, Oliver, additional, Pachynski, Russell K., additional, Maher, Christopher A., additional, and Chaudhuri, Aadel A., additional

Published
2023
Full Text
View/download PDF

15. Supplementary Figure S3 from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

Author

Fox, Gregory C., primary, Su, Xinming, primary, Davis, Jennifer L., primary, Xu, Yalin, primary, Kwakwa, Kristin A., primary, Ross, Michael H., primary, Fontana, Francesca, primary, Xiang, Jingyu, primary, Esser, Alison K., primary, Cordell, Elizabeth, primary, Pagliai, Kristen, primary, Dang, Ha X., primary, Sivapackiam, Jothilingam, primary, Stewart, Sheila A., primary, Maher, Christopher A., primary, Bakewell, Suzanne J., primary, Fitzpatrick, James A.J., primary, Sharma, Vijay, primary, Achilefu, Samuel, primary, Veis, Deborah J., primary, Lanza, Gregory M., primary, and Weilbaecher, Katherine N., primary

Published
2023
Full Text
View/download PDF

16. Data from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

Author

Fox, Gregory C., primary, Su, Xinming, primary, Davis, Jennifer L., primary, Xu, Yalin, primary, Kwakwa, Kristin A., primary, Ross, Michael H., primary, Fontana, Francesca, primary, Xiang, Jingyu, primary, Esser, Alison K., primary, Cordell, Elizabeth, primary, Pagliai, Kristen, primary, Dang, Ha X., primary, Sivapackiam, Jothilingam, primary, Stewart, Sheila A., primary, Maher, Christopher A., primary, Bakewell, Suzanne J., primary, Fitzpatrick, James A.J., primary, Sharma, Vijay, primary, Achilefu, Samuel, primary, Veis, Deborah J., primary, Lanza, Gregory M., primary, and Weilbaecher, Katherine N., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Methods from Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

Author

Fox, Gregory C., primary, Su, Xinming, primary, Davis, Jennifer L., primary, Xu, Yalin, primary, Kwakwa, Kristin A., primary, Ross, Michael H., primary, Fontana, Francesca, primary, Xiang, Jingyu, primary, Esser, Alison K., primary, Cordell, Elizabeth, primary, Pagliai, Kristen, primary, Dang, Ha X., primary, Sivapackiam, Jothilingam, primary, Stewart, Sheila A., primary, Maher, Christopher A., primary, Bakewell, Suzanne J., primary, Fitzpatrick, James A.J., primary, Sharma, Vijay, primary, Achilefu, Samuel, primary, Veis, Deborah J., primary, Lanza, Gregory M., primary, and Weilbaecher, Katherine N., primary

Published
2023
Full Text
View/download PDF

19. Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression

Author

Silva-Fisher, Jessica M., Dang, Ha X., White, Nicole M., Strand, Matthew S., Krasnick, Bradley A., Rozycki, Emily B., Jeffers, Gejae G. L., Grossman, Julie G., Highkin, Maureen K., Tang, Cynthia, Cabanski, Christopher R., Eteleeb, Abdallah, Mudd, Jacqueline, Goedegebuure, S. Peter, Luo, Jingqin, Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J., Lockhart, Albert C., Fields, Ryan C., and Maher, Christopher A.

Published
2020
Full Text
View/download PDF

20. Supplementary Data 2 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
Full Text
View/download PDF

21. Supplementary Data 4 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
Full Text
View/download PDF

22. Data from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Data 3 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
Full Text
View/download PDF

24. Supplementary Figures from Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas

Author

Zhao, Shuang G., primary, Chen, William S., primary, Das, Rajdeep, primary, Chang, S. Laura, primary, Tomlins, Scott A., primary, Chou, Jonathan, primary, Quigley, David A., primary, Dang, Ha X., primary, Barnard, Travis J., primary, Mahal, Brandon A., primary, Gibb, Ewan A., primary, Liu, Yang, primary, Davicioni, Elai, primary, Duska, Linda R., primary, Posadas, Edwin M., primary, Jolly, Shruti, primary, Spratt, Daniel E., primary, Nguyen, Paul L., primary, Maher, Christopher A., primary, Small, Eric J., primary, and Feng, Felix Y., primary

Published
2023
Full Text
View/download PDF

25. Supplementary Data from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Data 1 from Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer

Author

Li, Yingming, primary, Yang, Rendong, primary, Henzler, Christine M., primary, Ho, Yeung, primary, Passow, Courtney, primary, Auch, Benjamin, primary, Carreira, Suzanne, primary, Nava Rodrigues, Daniel, primary, Bertan, Claudia, primary, Hwang, Tae Hyun, primary, Quigley, David A., primary, Dang, Ha X., primary, Morrissey, Colm, primary, Fraser, Michael, primary, Plymate, Stephen R., primary, Maher, Christopher A., primary, Feng, Felix Y., primary, de Bono, Johann S., primary, and Dehm, Scott M., primary

Published
2023
Full Text
View/download PDF

32. Liquid biopsy AR/enhancer alteration detection before AR-targeted therapy and correlation with survival in metastatic castrate-resistant prostate cancer patients.

Author

Shiang, Alexander, primary, Chauhan, Pradeep S., additional, Dang, Ha X., additional, Webster, Jace, additional, Ledet, Elisa M., additional, Babbra, Ramandeep K, additional, Feng, Wenjia, additional, Harris, Peter K., additional, Jaeger, Ellen B., additional, Miller, Patrick, additional, Caputo, Sydney, additional, Cittolin Santos, Giordano Fabricio, additional, Pachynski, Russell Kent, additional, Sartor, A. Oliver, additional, Maher, Christopher, additional, and Chaudhuri, Aadel A, additional

Published
2022
Full Text
View/download PDF

34. Abstract 577: A unified pipeline to detect small mutations, structural variations and copy number alterations from targeted cell-free DNA sequencing in cancer

Author

Dang, Ha X., primary, Webster, Jace, additional, Chauhan, Pradeep S., additional, Hartman, Steven H., additional, Feng, Wenjia, additional, Ledet, Elisa M., additional, Ellis, Haley, additional, Miller, Patrick J., additional, Jaeger, Ellen B., additional, Caputo, Sydney A., additional, Harris, Peter K., additional, Sartor, A. Oliver, additional, Pachynski, Russell K., additional, Chaudhuri, Aadel A., additional, and Maher, Christopher A., additional

Published
2021
Full Text
View/download PDF

35. Abstract 550: Cell-free DNA alterations in theAR/enhancer locus measured before AR signaling inhibition portend poor overall survival in metastatic castration resistant prostate cancer patients

Author

Chauhan, Pradeep Singh, primary, Hartman, Steven H., additional, Dang, Ha X., additional, Webster, Jace, additional, Ellis, Haley, additional, Feng, Wenjia, additional, Harris, Peter K., additional, Ledet, Elisa M., additional, Jaeger, Ellen B., additional, Miller, Patrick J., additional, Caputo, Sydney A., additional, Pachynski, Russell K., additional, Sartor, Oliver, additional, Maher, Christopher A., additional, and Chaudhuri, Aadel A., additional

Published
2021
Full Text
View/download PDF

38. Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

Author

Fox, Gregory C., primary, Su, Xinming, additional, Davis, Jennifer L., additional, Xu, Yalin, additional, Kwakwa, Kristin A., additional, Ross, Michael H., additional, Fontana, Francesca, additional, Xiang, Jingyu, additional, Esser, Alison K., additional, Cordell, Elizabeth, additional, Pagliai, Kristen, additional, Dang, Ha X., additional, Sivapackiam, Jothilingam, additional, Stewart, Sheila A., additional, Maher, Christopher A., additional, Bakewell, Suzanne J., additional, Fitzpatrick, James A.J., additional, Sharma, Vijay, additional, Achilefu, Samuel, additional, Veis, Deborah J., additional, Lanza, Gregory M., additional, and Weilbaecher, Katherine N., additional

Published
2021
Full Text
View/download PDF

39. Cell-Free DNA Alterations in the AR Enhancer and Locus Predict Resistance to AR-Directed Therapy in Patients With Metastatic Prostate Cancer

Author

Dang, Ha X., primary, Chauhan, Pradeep S., additional, Ellis, Haley, additional, Feng, Wenjia, additional, Harris, Peter K., additional, Smith, Grace, additional, Qiao, Mark, additional, Dienstbach, Katherine, additional, Beck, Rachel, additional, Atkocius, Andrew, additional, Qaium, Faridi, additional, Luo, Jingqin, additional, Michalski, Jeff M., additional, Picus, Joel, additional, Pachynski, Russell K., additional, Maher, Christopher A., additional, and Chaudhuri, Aadel A., additional

Published
2020
Full Text
View/download PDF

40. Abstract LB-269: Detection of cell-free DNA alterations in AR and its enhancer significantly outperformed CTC AR-V7 detection for identifying treatment resistance in patients with metastatic prostate cancer

Author

Chauhan, Pradeep S., primary, Dang, Ha X., additional, Ellis, Haley, additional, Feng, Wenjia, additional, Harris, Peter K., additional, Smith, Grace, additional, Qiao, Mark, additional, Dienstbach, Katherine, additional, Beck, Rachel, additional, Atkocius, Andrew, additional, Qaium, Faridi, additional, Luo, Jingqin, additional, Michalski, Jeff M., additional, Picus, Joel, additional, Pachynski, Russell K., additional, Maher, Christopher A., additional, and Chaudhuri, Aadel A., additional

Published
2020
Full Text
View/download PDF

42. The clonal evolution of metastatic colorectal cancer

Author

Dang, Ha X., primary, Krasnick, Bradley A., additional, White, Brian S., additional, Grossman, Julie G., additional, Strand, Matthew S., additional, Zhang, Jin, additional, Cabanski, Christopher R., additional, Miller, Christopher A., additional, Fulton, Robert S., additional, Goedegebuure, S. Peter, additional, Fronick, Catrina C., additional, Griffith, Malachi, additional, Larson, David E., additional, Goetz, Brian D., additional, Walker, Jason R., additional, Hawkins, William G., additional, Strasberg, Steven M., additional, Linehan, David C., additional, Lim, Kian H., additional, Lockhart, A. Craig, additional, Mardis, Elaine R., additional, Wilson, Richard K., additional, Ley, Timothy J., additional, Maher, Christopher A., additional, and Fields, Ryan C., additional

Published
2020
Full Text
View/download PDF

43. AR enhancer and locus genomic alterations as cell-free DNA biomarkers of primary resistance to AR-directed treatment of metastatic prostate cancer.

Author

Maher, Chris, primary, Dang, Ha X., additional, Chauhan, Pradeep S., additional, Ellis, Haley, additional, Feng, Wenjia, additional, Harris, Peter, additional, Smith, Grace, additional, Qiao, Mark, additional, Dienstbach, Katherine, additional, Beck, Rachel, additional, Atkocius, Andrew, additional, Qaium, Faridi, additional, Luo, Jingqin, additional, Michalski, Jeff, additional, Picus, Joel, additional, Pachynski, Russell Kent, additional, and Chaudhuri, Aadel, additional

Published
2020
Full Text
View/download PDF

45. Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas

Author

Zhao, Shuang G., primary, Chen, William S., additional, Das, Rajdeep, additional, Chang, S. Laura, additional, Tomlins, Scott A., additional, Chou, Jonathan, additional, Quigley, David A., additional, Dang, Ha X., additional, Barnard, Travis J., additional, Mahal, Brandon A., additional, Gibb, Ewan A., additional, Liu, Yang, additional, Davicioni, Elai, additional, Duska, Linda R., additional, Posadas, Edwin M., additional, Jolly, Shruti, additional, Spratt, Daniel E., additional, Nguyen, Paul L., additional, Maher, Christopher A., additional, Small, Eric J., additional, and Feng, Felix Y., additional

Published
2019
Full Text
View/download PDF

46. Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis

Author

Kale, Shiv D., primary, Ayubi, Tariq, additional, Chung, Dawoon, additional, Tubau-Juni, Nuria, additional, Leber, Andrew, additional, Dang, Ha X., additional, Karyala, Saikumar, additional, Hontecillas, Raquel, additional, Lawrence, Christopher B., additional, Cramer, Robert A., additional, and Bassaganya-Riera, Josep, additional

Published
2017
Full Text
View/download PDF

50. Multi-institutional Analysis Shows that Low PCAT-14 Expression Associates with Poor Outcomes in Prostate Cancer

Author

White, Nicole M., primary, Zhao, Shuang G., additional, Zhang, Jin, additional, Rozycki, Emily B., additional, Dang, Ha X., additional, McFadden, Sandra D., additional, Eteleeb, Abdallah M., additional, Alshalalfa, Mohammed, additional, Vergara, Ismael A., additional, Erho, Nicholas, additional, Arbeit, Jeffrey M., additional, Karnes, Robert Jeffrey, additional, Den, Robert B., additional, Davicioni, Elai, additional, and Maher, Christopher A., additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results