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Your search keyword '"Dang, H.-H."' showing total 9 results
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9 results on '"Dang, H.-H."'

5. Scientific Reports / Unbiased quantitative proteomics reveals a crucial role of the allergen context for the activation of human dendritic cells

Author

Strasser, L., Dang, H.-H., Schwarz, H., Asam, C., Ferreira, F., Horejs-Hoeck, and Huber, C. G.

Abstract

Worldwide, more than 1 billion people suffer from allergic diseases. However, until now it is not fully understood how certain proteins can induce allergic immune responses, while others cannot. Studies suggest that allergenicity is a process not only determined by properties of the allergen itself but also by costimulatory factors, that are not classically associated with allergic reactions. To investigate the allergenicity of the major birch pollen allergen Bet v 1 and the impact of adjuvants associated with pollen, e.g. lipopolysaccharide (LPS), we performed quantitative proteome analysis to study the activation of monocyte-derived dendritic cells (moDCs). Thus, we treated cells with birch pollen extract (BPE), recombinant Bet v 1, and LPS followed by proteomic profiling via high-performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS) using isobaric labelling. Enrichment and pathway analysis revealed the influence of regulated proteins especially in cytokine signalling and dendritic cell activation. We found highly regulated, but differentially expressed proteins after treatment with BPE and LPS, whereas the cellular response to Bet v 1 was limited. Our findings lead to the conclusion that Bet v 1 needs a specific "allergen context" involving cofactors apart from LPS to induce an immune response in human moDCs. P25696 (VLID)2382950

Published
2017

9. Crohn's disease of the vulva.

Author

Andreani SM, Ratnasingham K, Dang HH, Gravante G, and Giordano P

Subjects
Anti-Infective Agents therapeutic use, Anti-Inflammatory Agents therapeutic use, Combined Modality Therapy, Crohn Disease diagnosis, Crohn Disease drug therapy, Female, Humans, Metronidazole therapeutic use, Prednisolone therapeutic use, Vulvar Diseases diagnosis, Vulvar Diseases drug therapy, Crohn Disease surgery, Vulvar Diseases surgery
Abstract

Crohn's involvement of the Vulva is unfamiliar and difficult to treat. The aim is to review the presentation, clinical course and different treatments of Vulva Crohn's disease (CD). We have reviewed the literature without language barrier from 1966 to 2009 through Pubmed with the following words: vulva and CD, vulvitis and CD, genital CD. We included articles that had Crohn's involvement of the vulva arising from a distant site (metastatic) or arising from a Crohn's fistula from the perineum and/or anorectum. We excluded CD of other gynaecological organs. One hundred thirty six abstracts were identified and related articles reviewed. Fifty-five cases of CD of the vulva were included in the final anlaysis of this review. Vulva involvement is rare and gives long-term discomfort. A combined medical therapy (metronidazole with prednisolone) appears to be the most effective treatment. The surgical approach should be reserved for non-responding cases. CD is often unrecognized cause of vulva pain and difficult to diagnose. However if diagnosed and adequately treated it usually responds to conservative therapies., (Copyright 2009 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.)

Published
2010
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