10 results on '"Danaci, Ayşen Esen"'
Search Results
2. The developmental origins of metacognitive deficits in schizophrenia
- Author
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Aydin, Orkun, Balikci, Kuzeymen, Tas, Cumhur, Aydin, Pınar Unal, Danaci, Aysen Esen, Brüne, Martin, and Lysaker, Paul H.
- Published
- 2016
- Full Text
- View/download PDF
3. MANİSA’DA ŞİZOFREN HASTALARIN SİTOGENETİK ANALİZİ VE POLİMERAZ ZİNCİR REAKSİYONU İLE COMT( 21q11.2 ) GENİNİN TEŞHİSİ
- Author
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ARSLAN, Elvan, ALTINTAŞ, Nuray, AYER, Ahmet, DANACI, Ayşen Esen, AŞÇI, Mustafa, and ÖRENAY, Seda
- Subjects
mental disorders ,Schizophrenia,22q11.2 microdeletion,PCR,COMT ,Şizofreni,22q11.2 mikrodelesyonu,PZR,COMT ,behavioral disciplines and activities - Abstract
Şizofreni birçok davranış ve düşünce bozukluğuna neden olan çok sistemli psikiyatrik bozukluklardan biridir. Erken yaşlarda başlayarak hayat boyu süren, sonlanımı kötü olan bir hastalıktır. Biyokimyasal, anatomik ve genetik alanlardaki birçok ilerlemelere karşın şizofreni kendine özgü yaşantıları ve davranışsal belirtileri olan ve ancak bu belirtilerin gözlenmesi ile tanı konabilen bir hastalık olarak kalmaya devam etmektedir. Çalışmamızın amacı, DSM-IV (Ruhsal Bozuklukların Tanısal ve Sayımsal El Kitabı) kriterlerine göre şizofreni tanısı konmuş 50 hastanın (25 kadın ve 25 erkek) sitogenetik analizlerini yaparak, sayısal ve yapısal kromozom anomalilerini belirlemek ve Polimeraz Zincir Reaksiyonu (PZR) yöntemi ile 22q11.2 bölgesindeki cathecol-O-methyltransferase belirlemektir. Araştırmamızın sitogenetik analizinde lenfosit kültürü ve Giemsa-Tripsin (GTG) bantlaması yapılarak ışık mikroskobunda incelendi. Genomik DNA, periferik kandan Nucleospin izolasyon kiti ile elde edildi. Oligonukleotid primerler kullanılarak PZR yöntemi ile kromozom 22q11.2 bölgesindeki 109 baz çifti uzunluğundaki COMT geni elde edildi. PZR ürünü, %2 lik agaroz jelde yürütülüp jel görüntüleme sisteminde resimlendi. Bu ön çalışmada Manisa’da yaşayan şizofren hastalarda şizofrene yatkınlıkta aday genlerden cathecolO-methyltransferase (COMT) olarak kodlanan COMT (22.q11.2) geni saptanmış oldu, Schizophrenia is one of the multisystemic diseases that cause many behavioral and thinking problems. It is an evil disease that begins in the childhood and goes till the end of life. Although there are lots of advances in biochemical, anatomical and genetical areas, schizophrenia remains to be a disease with its unique characteristics having its own life and behavioral symptoms. It is by means of observing these symptoms that the aim of our study is to determine the numerical or structural abnormalities with the disease is diagnosed cytogenetic analysis of 50 patients (25 female, 25 male) who were diagnosed as schizophrenia by using the DSM-IV (Diagnostic and Statistical Manual of Mental Disorders), criteria and to identify the CathecolO-Methyltransferase (COMT) gene on 22q11.2 region by using Polymerase Chain Reaction (PCR) method. In cytogenetic analyse of our study lymphocyte culture and Giemsa-Tripsin (GTG) banding have been done and examined under light microscope. Genomic DNA was extracted from peripheral blood by using Nucleospin isolation kits. COMT gene which is 109 bp lenght and belongs to 22q11.2 chromosome is duplicated by PCR method using oligonucleotid primers. PCR product has been performed in %2 agarose gel and imaged by gel screening system. With this preliminary study the COM (22.q11.2) gene encoding cathecol-O-methyltransferase (COMT) a functional candidate gene for schizophrenia, was found in the patients with schizophrenia who were living in Manisa province
- Published
- 2011
4. Tıp Eğitiminin Şizofreniye Yönelik Tutumlar Üzerine Etkisi; 5 Yıllık İzlem Çalışması.
- Author
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DANACI, Ayşen ESEN, BALIKÇI, Kuzeymen, AYDIN, Orkun, CENGİSİZ, Cengiz, and UYKUR, A. Burak
- Subjects
MENTAL health education ,SCHIZOPHRENIA treatment ,ETIOLOGY of schizophrenia ,MEDICAL personnel ,FOLLOW-up studies (Medicine) - Abstract
Copyright of Turk Psikiyatri Dergisi is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
- Full Text
- View/download PDF
5. The Perceived Burden of Care and its Correlates in Schizophrenia.
- Author
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Gülseren, Leyla, Çam, Birmay, Karakoç, Berna, Yiğit, Tamer, Danaci, Ayşen Esen, Çubukçuoğlu, Zeynep, Taş, Cumhur, Gülseren, Şeref, and Mete, Levent
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BURDEN of care ,SCHIZOPHRENIA ,PSYCHOLOGICAL stress ,MENTAL illness ,BECK Depression Inventory - Abstract
Objective: The present study aimed to investigate the perceived level of burden of care and its correlates in family members of schizophrenia patients. Method: The study included 239 schizophrenic patients that were followed-up at the psychiatric outpatient clinics of Izmir Ataturk Education and Research Hospital, and Celal Bayar University Medical School, and 239 of their primary caregivers. Patients were assessed using the Positive and Negative Syndrome Scale (PANNS), Global Assessment of Functioning Scale (GAF), Social Functioning Scale (SFS), Brief Cognitive State Examination (BCE), and UKU Side Effect Rating Scale. Their primary caregivers were assessed using the Perceived Family Burden Scale (PFBS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Results: Caregiver PFBS scores ere correlated with male patients, female caregivers, inadequate social support, economic difficulty, the presence of chronic physical disorder in the caregivers, patient violence toward the caregivers, total duration of illness, the number of patient hospitalizations, PANNS total and subscale scores, and SFS, BDI, and BAI scores. Perceived burden of care was predicted by the severity of the patients' positive symptoms, SFS independence/competence and interpersonal functioning subscale scores, and caregivers' anxiety and depression levels. Conclusion: In order to decrease the burden of care in schizophrenia we recommend effective management of patient symptoms, enhancement of patient social functioning, interventions that target caregivers with highlevels anxiety and depression, and social support provided by healthcare professionals. [ABSTRACT FROM AUTHOR]
- Published
- 2010
6. Reliability and Validity of the Turkish Version of the Social Adaptation Self-Evaluation Scale (SASS).
- Author
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Akkaya, Cengiz, Sarandöl, Aslı, Danaci, Ayşen Esen, Sıvrıo011F;lu, E. Yusuf, Kaya, Ender, and Kirli, Selçuk
- Subjects
MENTAL depression ,PATHOLOGICAL psychology ,DEPRESSED persons ,PEOPLE with mental illness ,MEDICAL research ,FACTOR analysis - Abstract
Objective: SASS is a new self-evaluation scale that assesses the level of social functioning in depressed patients for clinical research purposes. The aim of this study was to investigate the validity and reliability of the Turkish version of SASS. Method: Data were obtained from 2 different sample groups that had no physical disturbances that could impair social functioning; healthy participants between the ages of 18 and 65 years (n = 66) and patients (n = 227) diagnosed with major depressive disorder (MDD). Assessment tools used in the study were SASS, Hamilton Depression Rating Scale, 17-item version, and Global Assessment of Functioning Scale. Results: In the reliability analysis of both groups combined and the MDD group Cronbach's alpha values for the internal consistency of the scale were 0.90 and 0.87, respectively. Item-total score correlations were between 0.22 and 0.66 for both groups combined, and between 0.21 and 0.59 for the MDD group. The correlation coefficient of the scale's test-retest reliability was 0.770 (P < 0.0001) and the SASS value rose from 29.4 ± 8.1 to 37.8 ± 8.1 following treatment of depression (P < 0.0001). Four factors with Eigen values > 1 were obtained from the factor analysis. Factor 1, with an Eigen value of 7.169 explained 35.8% of the total variance and represented the entire scale alone. Conclusions: The Turkish version of SASS, as the original scale, demonstrated adequate validity and reliability for the measurement of loss of social functioning in MDD patients and demonstrated that scores changed in accordance with treatment for depression. [ABSTRACT FROM AUTHOR]
- Published
- 2008
7. Sosyal Uyum Kendini Değerlendirme Ölçeği (SUKDÖ) Türkçe Formunun Geçerlik ve Güvenilirliği.
- Author
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Akkaya, Cengiz, Sarandöl, Aslı, Danaci, Ayşen Esen, Sivrioğlu, E. Yusuf, Kaya, Ender, and Kirli, Selçuk
- Subjects
SOCIAL adjustment ,MENTAL depression ,THERAPEUTICS ,SELF-evaluation ,STATISTICAL correlation ,FACTOR analysis ,SOCIAL psychology - Abstract
Copyright of Turk Psikiyatri Dergisi is the property of Turk Psikiyatri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2008
8. Postnatal depression in turkey: epidemiological and cultural aspects.
- Author
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Danaci, Aysen Esen, Dinc, Gonul, Deveci, Artuner, Seyfe, Firdevs, Icelli, Sen Ilkin, Danaci, Ayşen Esen, Dinç, Gönül, Sen, Firdevs Seyfe, and Içelli, Ilkin
- Subjects
POSTPARTUM depression ,EPIDEMIOLOGY ,MENTAL illness - Abstract
Background: In some periods of a woman's life the risk of depression increases and the postnatal period is one of these. The prevalence and the risk factors of postnatal depression are not systematically studied in Turkey. The aim of this study is to investigate the epidemiological aspects and the cultural factors that may affect postnatal depression in our country.Method: According to the records of ten primary health care centres in Manisa, a city in western Turkey, there were 1,337 women who had given birth in the previous 6 months. A sample group of 317 mothers were randomised among these women and 257 (81.7%) of the sample group could be reached. Data were collected by use of the Edinburgh Postnatal Depression Scale and a questionnaire on sociodemographic variables designed for this study.Results: The mean depression score was found to be 7.54 +/- 4.66. When the cut-off point was taken into consideration, 14% of mothers had a syndromal depression. The factors which affected the prevalence of depression were the number of living children, living in a shanty, being an immigrant, serious health problems in the baby, previous psychiatric history, psychiatric disorder in the spouse, and having bad relations with the spouse and his parents.Conclusion: These findings revealed that the prevalence of postnatal depression in the Manisa province and the factors affecting it were very similar to other studies; but the negative impact of bad relations of the mother with her family-in-law on postnatal depression seems to be a distinguishing aspect of Turkish culture. [ABSTRACT FROM AUTHOR]- Published
- 2002
- Full Text
- View/download PDF
9. [The symptomatology and prevalence of symptoms of premenstrual syndrome in Manisa, Turkey].
- Author
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Adigüzel H, Taşkin EO, and Danaci AE
- Subjects
- Adolescent, Adult, Female, Fertility, Humans, Interviews as Topic, Middle Aged, Premenstrual Syndrome etiology, Premenstrual Syndrome pathology, Prevalence, Psychiatric Status Rating Scales, Severity of Illness Index, Socioeconomic Factors, Turkey epidemiology, Premenstrual Syndrome epidemiology, Premenstrual Syndrome psychology
- Abstract
Objective: The aim of this study was to investigate the prevalence of premenstrual syndrome (PMS) symptoms, the frequency and severity of the symptoms, and their association with sociodemographic variables in fertile women between the ages of 15 and 49 years., Method: The study included 541 women living in the area of the 7th Primary Health Care Center of Manisa, Turkey. Face-to-face interviews were conducted and a sociodemographic data form, a DSM-IV diagnostic criteria form, and the premenstrual evaluation form (PEF) were administered. In the analysis of the data, K-means cluster analysis was performed and cluster analysis with 3 categories according to the severity was used. In the evaluation of the 18 subscales possible maximum variation quotient is obtained by dividing the maximum possible PEF score to the scores the subjects got. In the group comparison analyses, chi-square test for the categorical variables, and t-test for continuous variables were used., Results: Among the study group, 6.1% had severe PMS symptoms and 72.2% of these women had some dysfunction as defined by DSM-IV. The most common symptoms were feeling irritable and restless (72%), anxiety (67.3%), feeling fullness, discomfort or pain in the abdomen (66.6%), lack of energy or easily fatigued (66.6%), and fatigue in the legs (65.5%)., Conclusion: The prevalence of the risk of PMS was 6.1%. The most common and severe PMS symptoms were feeling irritable and restless.
- Published
- 2007
10. Developing a quality of life instrument in patients with psoriasis: the Psoriasis Quality of Life Questionnaire (PQLQ).
- Author
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Inanir I, Aydemir O, Gündüz K, Danaci AE, and Türel A
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Islam, Male, Middle Aged, Reproducibility of Results, Stress, Psychological, Turkey ethnology, Health Status Indicators, Psoriasis psychology, Quality of Life, Surveys and Questionnaires
- Abstract
Background and Design: Psoriasis is a chronic skin disease which causes psychological, social and physical problems and affects quality of life. The aim of this study was to develop a quality of life instrument for patients with psoriasis which is suitable for Islamic populations., Materials and Methods: The psychosocial and daily life problems defined by 75 patients with psoriasis, their relatives and physicians were used to construct a questionnaire, the reliability and validity of which were determined in a group of 156 patients with psoriasis., Results: For reliability, Chronbach's alpha coefficient was 0.87, and item-total correlations were between 0.37 and 0.60 for internal consistency. There was high test-retest reliability (r = 0.98, P < 0.001). For validity, three factors were extracted in the principal components method for construct validity. The maximum factor loadings of each item were between 0.456 and 0.681. For convergent validity, all patients' self-ratings and Psoriasis Area and Severity Index (PASI) were correlated with the questionnaire score (P < 0.001)., Conclusion: The questionnaire consisting of 17 items was found to be suitable for both epidemiologic and clinical trials.
- Published
- 2006
- Full Text
- View/download PDF
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