1. Psychological well-being in patients with aneurysms-osteoarthritis syndrome.
- Author
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Bons LR, van den Hoven AT, Damirchi AE, van der Linde D, Dekker S, Kauling RM, van de Laar IMBH, Utens EMWJ, Budde RPJ, and Roos-Hesselink JW
- Subjects
- Adolescent, Adult, Aged, Aortic Dissection genetics, Aortic Dissection physiopathology, Anxiety genetics, Anxiety physiopathology, Aortic Aneurysm genetics, Aortic Aneurysm physiopathology, Case-Control Studies, Depression genetics, Depression physiopathology, Female, Gene Expression, Heterozygote, Humans, Male, Marfan Syndrome genetics, Marfan Syndrome physiopathology, Middle Aged, Mutation, Osteoarthritis genetics, Osteoarthritis physiopathology, Pain genetics, Pain physiopathology, Quality of Life psychology, Smad3 Protein genetics, Surveys and Questionnaires, Syndrome, Aortic Dissection psychology, Anxiety psychology, Aortic Aneurysm psychology, Depression psychology, Marfan Syndrome psychology, Osteoarthritis psychology, Pain psychology
- Abstract
Aneurysms-osteoarthritis syndrome (AOS) is characterized by arterial aneurysms and dissection in combination with early-onset osteoarthritis, which can impact quality of life. We describe the subjective quality of life and investigate anxiety and depression in 28 AOS patients aged 15-73 years. Three questionnaires were used: 36-Item Short Form Survey (SF-36), hospital anxiety and depression scale (HADS) and Rotterdam disease specific questionnaire. Results of the SF-36 and HADS were compared to a reference Dutch cohort and the SF-36 questionnaire also to patients with Marfan syndrome. Compared to the general population, AOS patients scored significantly lower on the following SF-36 domains: physical functioning, vitality, social functioning, bodily pain, and general health. Physical functioning was also lower than in Marfan patients. Patients with AOS scored higher on the HADS depression scale, while anxiety did not show a significant difference compared to the general population. No difference in SF-36 and HADS domain scores were found between patient with and without orthopaedic symptoms and patients with or without previous aortic surgery. Additionally, we found that patients' worries for their future and heredity of their disease are important factors for anxiety, which should be addressed in clinical practice., (© 2019 The Authors. American Journal of Medical Genetics Part A published by Wiley Periodicals, Inc.)
- Published
- 2019
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