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1. Quality indicators in intensive care medicine for Germany – fourth edition 2022

Author

Kumpf, Oliver, Assenheimer, Markus, Bloos, Frank, Brauchle, Maria, Braun, Jan-Peter, Brinkmann, Alexander, Czorlich, Patrick, Dame, Christof, Dubb, Rolf, Gahn, Georg, Greim, Clemens-A., Gruber, Bernd, Habermehl, Hilmar, Herting, Egbert, Kaltwasser, Arnold, Krotsetis, Sabine, Kruger, Bastian, Markewitz, Andreas, Marx, Gernot, Muhl, Elke, Nydahl, Peter, Pelz, Sabrina, Sasse, Michael, Schaller, Stefan J., Schäfer, Andreas, Schürholz, Tobias, Ufelmann, Marina, Waydhas, Christian, Weimann, Jörg, Wildenauer, René, Wöbker, Gabriele, Wrigge, Hermann, and Riessen, Reimer

Subjects
quality management, intensive care medicine, quality indicators, peer review, Medicine
Abstract

The measurement of quality indicators supports quality improvement initiatives. The German Interdisciplinary Society of Intensive Care Medicine (DIVI) has published quality indicators for intensive care medicine for the fourth time now. After a scheduled evaluation after three years, changes in several indicators were made. Other indicators were not changed or only minimally. The focus remained strongly on relevant treatment processes like management of analgesia and sedation, mechanical ventilation and weaning, and infections in the ICU. Another focus was communication inside the ICU. The number of 1ndicators remained the same. The development method was more structured and transparency was increased by adding new features like evidence levels or author contribution and potential conflicts of interest. These quality indicators should be used in the peer review in intensive care, a method endorsed by the DIVI. Other forms of measurement and evaluation are also reasonable, for example in quality management. This fourth edition of the quality indicators will be updated in the future to reflect the recently published recommendations on the structure of intensive care units by the DIVI.

Published
2023
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3. Supplemental Iron and Recombinant Erythropoietin for Anemia in Infants Born Very Preterm: A Survey of Clinical Practice in Europe

Author

Reibel-Georgi, Nora J., Scrivens, Alexandra, Heeger, Lisanne E., Lopriore, Enrico, New, Helen V., Deschmann, Emöke, Stanworth, Simon J., Carrascosa, Marta Aguar, Brække, Kristin, Cardona, Francesco, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Krivec, Jana Lozar, Matasova, Katarina, Muehlbacher, Tobias, Sankilampi, Ulla, Soares, Henrique, Szabó, Miklós, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph, Fustolo-Gunnink, Suzanne, and Dame, Christof

Published
2025
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4. Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study

Author

Alsina-Casanova, Miguel, Andersson, Ola, Arias-Llorente, Rosa Patricia, Berenger, Adeline, Bielska, Edyta, Boia, Marioara, Birkenmaier, André, Biros, Jakub, Blanquart, Anne Laure, Boggini, Tiziana, Boileau, Pascal, Bokiniec, Renata, Bresesti, Ilia, Broad, Katherine, Cavallaro, Giacomo, Chauvel, Jennifer, Cseszneki, Borbála, Dani, Carlo, Demová, Klaudia, Dornis, Diana, Duban, Marie-Pierre, Dziadkowiec-Motyl, Karolina, Erzen, Nika, Fanczal, Eszter, Fernández-Castiñeira, Sara, Galuschka, Libusa, Gandaputra, Ellen, García-Muñoz Rodrigo, Fermín, Gebauer, Corinna, Grimault, Hélène, Grund, Kristina, Gsöllpointner, Melanie, Gualdi, Silvia, Guaragni, Brunetta, Hahn, Markus, Haiden, Nadja, Hasmasanu, Monica, Iacob, Daniela, Ivanici, Mihaela, Jernej, Raphaela, Juren, Tomáš, Karcz, Karolina, Kornhauser, Lilijana, Królak-Olejnik, Barbara, Legnevall, Lena, Lehnerer, Verena, Levine, Emmanuelle, Ley, David, Del Carmen López Castillo, María, Magarotto, Mariella, Martini, Silvia, Maruniak-Chudek, Iwona, Moita, Rita, Mosuro, Anjola, Nowicka, Agnieszka, O'Reilly, Daniel, Pantea, Manuela, Pérez-Muñuzuri, Alejandro, Perme, Tina, Picciau, Laura, Pratesi, Simone, Prins, Sandra, Radicioni, Maurizio, Raffaeli, Genny, Roldan-López, Reyes, Roué, Jean-Michel, Węglarz, Beata Rzepecka, Sibrecht, Greta, Snijder, Pauline, Starčević, Mirta, Szántó, Emese, Teixeira, Liliana, Torrejon, Laura, Martí, Lourdes Urquía, Vanbuggenhout, Laurien, Zanetto, Lorenzo, Houben, Nina A.M., Lopriore, Enrico, Fijnvandraat, Karin, Caram-Deelder, Camila, Carrascosa, Marta Aguar, Beuchée, Alain, Brække, Kristin, Cardona, Francesco, Debeer, Anne, Domingues, Sara, Ghirardello, Stefano, Grizelj, Ruza, Hadžimuratović, Emina, Heiring, Christian, Krivec, Jana Lozar, Malý, Jan, Matasova, Katarina, Moore, Carmel Maria, Muehlbacher, Tobias, Szabó, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, de Jager, Justine, Reibel-Georgi, Nora Johanna, New, Helen V., Stanworth, Simon J., Deschmann, Emöke, Roehr, Charles C., Dame, Christof, le Cessie, Saskia, van der Bom, Johanna, and Fustolo-Gunnink, Suzanne

Published
2024
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5. Monitoring and management of hemolytic disease of the fetus and newborn based on an international expert Delphi consensus

Author

Nassr, Ahmed A., Baschat, Ahmet, Hohnecker, Alexander, Shamshirsaz, Alireza, Luciano, Angel, Debeer, Anne, Geipel, Annegret, Borrell, Antoni, Khalil, Asma, Llorente, Aurora Viejo, Mayer, Beate, Poljak, Borna, van der Schoot, C. Ellen, Taillefer, Catherine, Dame, Christof, Berg, Christoph, Coutinho, Conrado Milani, de Winter, Derek P., Oepkes, Dick, Verweij, E.J.T., Moratonas, Elena Carreras, Tiblad, Eleonor, Bendel-Stenzel, Ellen, Maisonneuve, Emeline, Lopriore, Enrico, Vlachodimitropoulou, Evangelia, Prefumo, Federico, Maia, Fernando, Filho, Peixoto, Molina, Francisca S., Gonzalez, Gerardo Sepulveda, Gardener, Glenn, Sago, Haruhiko, Liley, Helen, Mustafa, Hiba, Schwach, Ingrid, Bedei, Ivonne, Castleman, James, Krivec, Jana Lozar, jouannic, Jean-marie, Miller, Jena, Pereira Nunes, Joana Filipa, Middeldorp, Johanna, Martinez, Josep M., Sundberg, Karin, Bligard, Katherine, Kohari, Katherine, Ishii, Keisuke, Moise, Kenneth, Le Duc, Kévin, Lewi, Liesbeth, Van Wyk, Lizelle, Otaño, Lucas, Sun, Luming, Geerts, Lut, Sanchez-Duran, M. Angeles, Bennasar, Mar, Vaena, Marcella, Gil, Maria M., Weems, Mark F., Kilby, Mark, de Haas, Masja, Saxonhouse, Matthew, Schenone, Mauro, Bahtiyar, Mert Ozan, Zaretsky, Michael V., Martinez Rodriguez, Miguel Angel, Habli, Mounira, Khalek, Nahla, Frost, Natalie, Griffiths, Pamela, Maurice, Paul, Dar, Pe'er, Lindgren, Peter, Chaveeva, Petya, Klaritsch, Philipp, Radhakrishnan, Prathima, Schuler, Rahel, Chmait, Ramen, Rose, Rebecca, Oever, Renske van 't, Jernman, Riina, Christensen, Robert, Cincotta, Robert, Axt-Fliedner, Roland, Devlieger, Roland, Donepudi, Roopali, Kumar, Sailesh, Verlohren, Stefan, Emery, Stephen P., Sainio, Susanna, Mehra, Suwan, Premru-Srsen, Tanja, Legler, Tobias, Sachs, Ulrich J., Basal, Vandana, Stefanovic, Vedran, Goodnight, William, Blumenfeld, Yair, Mustafa, Hiba J., Sambatur, Enaja V., Shamshirsaz, Alireza A., Johnson, Sonia, Moise, Kenneth J., Jr., Baschat, Ahmet A., (Joanne) Verweij, E.J.T., Javinani, Ali, Kilby, Mark D., and Snowise, Saul

Published
2024
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15. Survey of transfusion practices in preterm infants in Europe

Author

Neonatal Transfusion Network, Scrivens, Alexandra, Reibel, Nora Johanna, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Braekke, Kristin, Cardona, Francesco Stefano, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph, Fustolo-Gunnink, Suzanne, Brussels Heritage Lab, UZB Other, Clinical sciences, Growth and Development, Neonatology, Paediatric Haematology, AII - Infectious diseases, and ARD - Amsterdam Reproduction and Development

Subjects
data collection, Epidemiology, Pediatrics, Perinatology and Child Health, Child Health, Obstetrics and Gynecology, General Medicine, Pediatrics, Perinatology, and Child Health, Healthcare Disparities, neonatology
Abstract

BackgroundPreterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe and to compare our findings to three recent randomised controlled trials to understand how clinical practice relates to the trial data.MethodsFrom October to December 2020, we performed an online survey among 597 neonatal intensive care units (NICUs) caring for infants with a gestational age (GA) of ResultsResponses from 343 NICUs (response rate: 57%) are presented and showed substantial variation in clinical practice. For RBC transfusions, 70% of NICUs transfused at thresholds above the restrictive thresholds tested in the recent trials and 22% below the restrictive thresholds. For platelet transfusions, 57% of NICUs transfused at platelet count thresholds above 25×109/L in non-bleeding infants of GA of 9/L threshold was associated with a lower risk of harm in a recent trial. FFP transfusions were administered for coagulopathy without active bleeding in 39% and for hypotension in 25% of NICUs. Transfusion volume, duration and rate varied by factors up to several folds between NICUs.ConclusionsTransfusion thresholds and aspects of administration vary widely across European NICUs. In general, transfusion thresholds used tend to be more liberal compared with data from recent trials supporting the use of more restrictive thresholds. Further research is needed to identify the barriers and enablers to incorporation of recent trial findings into neonatal transfusion practice.

Published
2023

16. Survey of transfusion practices in preterm infants in Europe

Author

Scrivens, Alexandra; https://orcid.org/0000-0002-3429-8007, Reibel, Nora Johanna; https://orcid.org/0000-0002-6412-4606, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico; https://orcid.org/0000-0002-3513-5066, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Brække, Kristin, Cardona, Francesco Stefano; https://orcid.org/0000-0002-9993-617X, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias; https://orcid.org/0000-0001-8661-9645, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph; https://orcid.org/0000-0001-7965-4637, Fustolo-Gunnink, Suzanne, Neonatal Transfusion Network, Scrivens, Alexandra; https://orcid.org/0000-0002-3429-8007, Reibel, Nora Johanna; https://orcid.org/0000-0002-6412-4606, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico; https://orcid.org/0000-0002-3513-5066, New, Helen V, Dame, Christof, Fijnvandraat, Karin, Deschmann, Emöke, Aguar, Marta, Brække, Kristin, Cardona, Francesco Stefano; https://orcid.org/0000-0002-9993-617X, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Lozar, Jana, Matasova, Katarina, Muehlbacher, Tobias; https://orcid.org/0000-0001-8661-9645, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph; https://orcid.org/0000-0001-7965-4637, Fustolo-Gunnink, Suzanne, and Neonatal Transfusion Network

Abstract

BACKGROUND Preterm infants commonly receive red blood cell (RBC), platelet and fresh frozen plasma (FFP) transfusions. The aim of this Neonatal Transfusion Network survey was to describe current transfusion practices in Europe and to compare our findings to three recent randomised controlled trials to understand how clinical practice relates to the trial data. METHODS From October to December 2020, we performed an online survey among 597 neonatal intensive care units (NICUs) caring for infants with a gestational age (GA) of <32 weeks in 18 European countries. RESULTS Responses from 343 NICUs (response rate: 57%) are presented and showed substantial variation in clinical practice. For RBC transfusions, 70% of NICUs transfused at thresholds above the restrictive thresholds tested in the recent trials and 22% below the restrictive thresholds. For platelet transfusions, 57% of NICUs transfused at platelet count thresholds above 25×10$^{9}$/L in non-bleeding infants of GA of <28 weeks, while the 25×10$^{9}$/L threshold was associated with a lower risk of harm in a recent trial. FFP transfusions were administered for coagulopathy without active bleeding in 39% and for hypotension in 25% of NICUs. Transfusion volume, duration and rate varied by factors up to several folds between NICUs. CONCLUSIONS Transfusion thresholds and aspects of administration vary widely across European NICUs. In general, transfusion thresholds used tend to be more liberal compared with data from recent trials supporting the use of more restrictive thresholds. Further research is needed to identify the barriers and enablers to incorporation of recent trial findings into neonatal transfusion practice.

Published
2023

21. Survey of transfusion practices in preterm infants in Europe

Author

Scrivens, Alexandra, primary, Reibel, Nora Johanna, additional, Heeger, Lisanne, additional, Stanworth, Simon, additional, Lopriore, Enrico, additional, New, Helen V, additional, Dame, Christof, additional, Fijnvandraat, Karin, additional, Deschmann, Emöke, additional, Aguar, Marta, additional, Brække, Kristin, additional, Cardona, Francesco Stefano, additional, Cools, Filip, additional, Farrugia, Ryan, additional, Ghirardello, Stefano, additional, Lozar, Jana, additional, Matasova, Katarina, additional, Muehlbacher, Tobias, additional, Sankilampi, Ulla, additional, Soares, Henrique, additional, Szabo, Miklos, additional, Szczapa, Tomasz, additional, Zaharie, Gabriela, additional, Roehr, Charles Christoph, additional, and Fustolo-Gunnink, Suzanne, additional

Published
2023
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28. Fatal congenital copper transport defect caused by a homozygous likely pathogenic variant of SLC31A1.

Author

Dame, Christof, Horn, Denise, Schomburg, Lutz, Grünhagen, Johannes, Chillon, Thilo Samson, Tietze, Anna, Vogt, Annika, and Bührer, Christoph

Subjects
*COPPER, *SPINAL muscular atrophy, *NEWBORN infants, *INTRACRANIAL hemorrhage, *PULMONARY hypoplasia
Abstract

Known hereditary human diseases featuring impaired copper trafficking across cellular membranes involve ATP7A (Menkes disease, occipital horn disease, X‐linked spinal muscular atrophy type 3) and ATP7B (Wilson disease). Herein, we report a newborn infant of consanguineous parents with a homozygous pathogenic variant in a highly conserved sequence of SLC31A1, coding for the copper influx transporter 1, CTR1. This missense variant, c.236T > C, was detected by whole exome sequencing. The infant was born with pulmonary hypoplasia and suffered from severe respiratory distress immediately after birth, necessitating aggressive mechanical ventilation. At 2 weeks of age, multifocal brain hemorrhages were diagnosed by cerebral ultrasound and magnetic resonance imaging, together with increased tortuosity of cerebral arteries. Ensuing seizures were only partly controlled by antiepileptic drugs, and the infant became progressively comatose. Laboratory investigations revealed very low serum concentrations of copper and ceruloplasmin. No hair shaft abnormalities were detected by dermatoscopy or light microscopic analyses of embedded hair shafts obtained at 4 weeks of life. The infant died after redirection of care and elective cessation of invasive mechanical ventilation at 1 month of age. This case adds SLC31A1 to the genes implicated in severe hereditary disorders of copper transport in humans. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Current Understanding of Transfusion-associated Necrotizing Enterocolitis: Review of Clinical and Experimental Studies and a Call for More Definitive Evidence

Author

Kumar, Praveen, primary, Garg, Parvesh M, additional, De Plaen, Isabelle G, additional, Christensen, Robert D, additional, Khashu, Minesh, additional, Dame, Christof, additional, Lavoie, Pascal M, additional, Sampath, Venkatesh, additional, Malhotra, Atul, additional, Caplan, Michael D, additional, Agrawal, Pankaj B, additional, Buonocore, Giuseppe, additional, and Maheshwari, Akhil, additional

Published
2022
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32. Adaptation of the Oxygen Sensing System during Lung Development

Author

Kirschner, Karin M., primary, Kelterborn, Simon, additional, Stehr, Herrmann, additional, Penzlin, Johanna L. T., additional, Jacobi, Charlotte L. J., additional, Endesfelder, Stefanie, additional, Sieg, Miriam, additional, Kruppa, Jochen, additional, Dame, Christof, additional, and Sciesielski, Lina K., additional

Published
2022
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34. Aberrant Hematopoiesis and Morbidity in Extremely Preterm Infants With Intrauterine Growth Restriction

Author

Reibel, Nora J, Dame, Christof, Bührer, Christoph, Muehlbacher, Tobias, University of Zurich, and Dame, Christof

Subjects
sepsis, Pediatrics, Perinatology and Child Health, coagulation disorder, neutropenia, 610 Medicine & health, thrombocytopenia, 2735 Pediatrics, Perinatology and Child Health, 10027 Clinic for Neonatology, Pediatrics, anemia, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Original Research
Abstract

Background and Objective: Intrauterine growth restriction (IUGR) poses additional challenges in extremely low gestational age newborns (ELGANs). We assessed disturbed hematopoiesis and morbidities associated with this disorder. Methods: This single-center retrospective case���control study compared perinatal hematological profiles, major morbidities, and mortality of 49 infants (gestational age 10th percentile) matched for gestational age, year, and sex. Results: IUGR-ELGANs had significantly elevated nucleated red blood cells and lower neutrophil and platelet counts at birth and on the third day of life. During the first week of life, IUGR-ELGANs received more red blood cell, platelet, and plasma transfusions and were more intensively treated with antibiotics. Rates of infections acquired during the first week (59.2 vs. 17.3%, p < 0.001), severe bronchopulmonary dysplasia or death (42.9 vs. 17.3%, p < 0.01), and mortality (36.7 vs. 7.1%, p < 0.001) were markedly elevated in IUGR-ELGANs, but not of hemorrhages or other morbidities. Conclusions: IUGR-ELGANs have high rates of acquired infections during the first week of life and display severe pulmonary morbidity leading to bronchopulmonary dysplasia or death. The high rate of transfusions observed in these infants warrants further scrutiny.

Published
2021
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36. Survey of transfusion practices in European preterm infants (step survey)

Author

Scrivens, Alexandra, Reibel, Nora-Johanna, Heeger, Lisanne, Stanworth, Simon, Lopriore, Enrico, New, Helen, Dame, Christof, Deschmann, Emoke, Fijnvandraat, Karin, van der Bom, Anske, Carrascosa, Marta Aguar, Braekke, Kristin, Cardona, Francesco, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Krivec, Jana Lozar, Matasova, Katarina, Muhlbacher, Tobias, Sankilampi, Ulla, Soares, Henrique, Szabo, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christof, Fustolo-Gunnink, Suzanne, Clinical sciences, Growth and Development, and Neonatology

Subjects
transfusion practices, Pediatrics, Perinatology, and Child Health, European preterm infants
Published
2021

39. Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants

Author

Sallmon, Hannes, Weimann, Andreas, Bührer, Christoph, Metze, Boris, Dame, Christof, and Cremer, Malte

Subjects
thrombopoiesis, Pediatrics, Perinatology and Child Health, very low birth weight infant, thrombocytopenia, Pediatrics, megakaryopoiesis, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Original Research, transfusion
Abstract

Objective: Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates. Methods: Prospective cohort study in thrombocytopenic (n = 31) and non-thrombocytopenic very low birth weight (VLBW) infants (n = 38), and healthy term neonates (controls; n = 41). Absolute platelet counts (APCs), IPCs, and Tpo concentrations were assessed by a fully-automated hematological analyzer (IPC, APC) and by ELISA (Tpo concentrations) in parallel on day 1 of life (d1), d3, and d7. Results: In healthy term neonates, APCs remained stable between d1 and d3. In non-thrombocytopenic VLBW infants, APCs increased from d1 to d7, while in the thrombocytopenia group, APCs declined from d1 to d3, before they slightly increased again by d7. Median IPCs were similar in healthy term vs. non-thrombocytopenic VLBW infants and remained stable between d1 and d3 (p > 0.05). Notably, IPCs significantly increased between d3 and d7 in both non-thrombocytopenic and thrombocytopenic VLBW infants. However, in thrombocytopenic VLBW infants, IPC values were significantly lower at each time point as compared to non-thrombocytopenic VLBWs (p < 0.001). In each subgroup, Tpo concentrations increased from d1 to d3. The median Tpo concentrations were significantly higher in thrombocytopenic as compared to non-thrombocytopenic VLBW infants at d3 (p = 0.01) and d7 (p = 0.002). Discussion: Term infants, thrombocytopenic, and non-thrombocytopenic preterm infants display similar developmental changes in indices of megakaryopoietic activity. In thrombocytopenic preterm infants, however, the responsive increases in Tpo and immature platelets appear to be developmentally limited.

Published
2021
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42. Epidemiology of Sepsis Among Children and Neonates in Germany: Results From an Observational Study Based on Nationwide Diagnosis-Related Groups Data Between 2010 and 2016

Author

Born, Sebastian, Dame, Christof, Matthäus-Krämer, Claudia, Schlapbach, Luregn J, Reichert, Felix, Schettler, Anna, Schwarzkopf, Daniel, Thomas-Rüddel, Daniel, Proquitté, Hans, Reinhart, Konrad, Fleischmann-Struzek, Carolin, and University of Zurich

Subjects
10036 Medical Clinic, 610 Medicine & health
Published
2021

44. Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum

Author

Thorwarth, Anne, Schnittert-Hübener, Sarah, Schrumpf, Pamela, Müller, Ines, Jyrch, Sabine, Dame, Christof, Biebermann, Heike, Kleinau, Gunnar, Katchanov, Juri, Schuelke, Markus, Ebert, Grit, Steininger, Anne, Bönnemann, Carsten, Brockmann, Knut, Christen, Hans-Jürgen, Crock, Patricia, deZegher, Francis, Griese, Matthias, Hewitt, Jacqueline, Ivarsson, Sten, Hübner, Christoph, Kapelari, Klaus, Plecko, Barbara, Rating, Dietz, Stoeva, Iva, Ropers, Hans-Hilger, Grüters, Annette, Ullmann, Reinhard, and Krude, Heiko

Published
2014
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45. Prophylactic Erythropoietin for Neuroprotection in Very Preterm Infants: A Meta-Analysis Update

Author

Fischer, Hendrik S., Reibel, Nora J., Bührer, Christoph, and Dame, Christof

Subjects
meta-analysis, VLBW and ELBW infants, neurodevelopment, Mini Review, neuroprotection, erythropoietin, Pediatrics, RJ1-570, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

A meta-analysis update of randomized controlled trials investigating recombinant human erythropoietin suggests improved neurodevelopmental outcome in preterm infants. There was substantial heterogeneity, which could be ascribed to a single trial. Exclusion of this trial featuring a high risk of bias abolished heterogeneity and any effects of recombinant human erythropoietin treatment.

Published
2021
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47. An approach to using recombinant erythropoietin for neuroprotection in very preterm infants

Author

Fauchere, Jean-Claude, Dame, Christof, Vonthein, Reinhard, Koller, Brigitte, Arri, Sandra, Wolf, Martin, and Bucher, Hans Ulrich

Subjects
Erythropoietin, Recombinant -- Dosage and administration, Erythropoietin, Recombinant -- Research, Infants (Premature) -- Drug therapy, Infants (Premature) -- Research, Brain -- Injuries, Brain -- Prevention
Published
2008

48. Fresh frozen plasma transfusion - a risk factor for pulmonary hemorrhage in extremely low birth weight infants?

Author

Usemann, Jakob, Garten, Lars, Bührer, Christoph, Dame, Christof, Cremer, Malte, Usemann, Jakob, Garten, Lars, Bührer, Christoph, Dame, Christof, and Cremer, Malte

Abstract

Aim: To evaluate risk factors for pulmonary hemorrhage (PH) in extremely low birth weight infants (ELBW) taking into consideration coagulation screens, platelet counts, transfusion of fresh frozen plasma (FFP), and platelet concentrates prior to PH. Patients and methods: A retrospective case-control study consisting of 20 ELBW infants with PH and 40 matched controls. Coagulation screens, platelet counts at birth and at onset of PH, and transfusion frequencies prior to PH were compared to case-controls at birth and 24-96 h after birth. Results: While the initial platelet counts, fibrinogen concentrations, and international normalized ratios were similar in PH infants and controls, the activated partial prothrombin time was prolonged (P=0.05). Compared to 28% of case controls (P<0.05), 55% of infants with later PH received FFP prior to PH. Platelet counts were significantly lower at onset of PH (median 81/nL; range: 37-236/nL) compared to controls (166/nL; 27-460/nL; P<0.005). Multivariate analysis indicated a lack of antenatal steroids, supplemental oxygen, and transfusion of FFP as independent risk factors for PH. Conclusion: Prolonged activated partial thromboplastin time (aPTT) might be associated with PH. PH does not primarily depend upon severe thrombocytopenia. A developmental mismatch in hemostasis by transfusion of adult donor plasma should be considered a risk factor for PH.

Published
2021

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