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Your search keyword '"Damani-Yokota, Payal"' showing total 22 results
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22 results on '"Damani-Yokota, Payal"'

1. Mouse genome rewriting and tailoring of three important disease loci

Author

Zhang, Weimin, Golynker, Ilona, Brosh, Ran, Fajardo, Alvaro, Zhu, Yinan, Wudzinska, Aleksandra M., Ordoñez, Raquel, Ribeiro-dos-Santos, André M., Carrau, Lucia, Damani-Yokota, Payal, Yeung, Stephen T., Khairallah, Camille, Vela Gartner, Antonio, Chalhoub, Noor, Huang, Emily, Ashe, Hannah J., Khanna, Kamal M., Maurano, Matthew T., Kim, Sang Yong, tenOever, Benjamin R., and Boeke, Jef D.

Published
2023
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8. Mouse genomic rewriting and tailoring: synthetic Trp53 and humanized ACE2

Author

Zhang, Weimin, primary, Golynker, Ilona, additional, Brosh, Ran, additional, Wudzinska, Aleksandra M., additional, Zhu, Yinan, additional, Carrau, Lucia, additional, Damani-Yokota, Payal, additional, Khairallah, Camille, additional, Chalhoub, Noor, additional, Huang, Emily, additional, Ashe, Hannah, additional, Khanna, Kamal M., additional, Maurano, Matthew T., additional, Kim, Sang Yong, additional, tenOever, Benjamin R., additional, and Boeke, Jef D., additional

Published
2022
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9. Type I interferon and MAVS signaling restricts chikungunya virus heart infection and cardiac tissue damage

Author

Noval, Maria Gabriela, primary, Bartnicki, Eric, additional, Spector, Sophie N., additional, Izzo, Franco, additional, Damani-Yokota, Payal, additional, Narula, Navneet, additional, Yeung, Stephen T., additional, Rodriguez-Rodriguez, Bruno A., additional, Dewan, M. Zahidunnabi, additional, Mezzano, Valeria, additional, Loomis, Cynthia, additional, Khanna, Kamal M., additional, and Stapleford, Kenneth A., additional

Published
2022
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10. Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

Author

Chen, Fei, primary, El-Naccache, Darine W., additional, Ponessa, John J., additional, Lemenze, Alexander, additional, Espinosa, Vanessa, additional, Wu, Wenhui, additional, Lothstein, Katherine, additional, Jin, Linhua, additional, Antao, Olivia, additional, Weinstein, Jason S., additional, Damani-Yokota, Payal, additional, Khanna, Kamal, additional, Murray, Peter J., additional, Rivera, Amariliz, additional, Siracusa, Mark C., additional, and Gause, William C., additional

Published
2022
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12. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Author

Lu, Qiao, primary, Liu, Jia, additional, Zhao, Shuai, additional, Gomez Castro, Maria Florencia, additional, Laurent-Rolle, Maudry, additional, Dong, Jianbo, additional, Ran, Xiaojuan, additional, Damani-Yokota, Payal, additional, Tang, Hongzhen, additional, Karakousi, Triantafyllia, additional, Son, Juhee, additional, Kaczmarek, Maria E., additional, Zhang, Ze, additional, Yeung, Stephen T., additional, McCune, Broc T., additional, Chen, Rita E., additional, Tang, Fei, additional, Ren, Xianwen, additional, Chen, Xufeng, additional, Hsu, Jack C.C., additional, Teplova, Marianna, additional, Huang, Betty, additional, Deng, Haijing, additional, Long, Zhilin, additional, Mudianto, Tenny, additional, Jin, Shumin, additional, Lin, Peng, additional, Du, Jasper, additional, Zang, Ruochen, additional, Su, Tina Tianjiao, additional, Herrera, Alberto, additional, Zhou, Ming, additional, Yan, Renhong, additional, Cui, Jia, additional, Zhu, James, additional, Zhou, Qiang, additional, Wang, Tao, additional, Ma, Jianzhu, additional, Koralov, Sergei B., additional, Zhang, Zemin, additional, Aifantis, Iannis, additional, Segal, Leopoldo N., additional, Diamond, Michael S., additional, Khanna, Kamal M., additional, Stapleford, Kenneth A., additional, Cresswell, Peter, additional, Liu, Yue, additional, Ding, Siyuan, additional, Xie, Qi, additional, and Wang, Jun, additional

Published
2021
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13. Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

Author

Chen, Fei, primary, El-Naccache, Darine W., additional, Ponessa, John J., additional, Lemenze, Alexander, additional, Espinosa, Vanessa, additional, Wu, Wenhui, additional, Lothstein, Katherine, additional, Jin, Linhua, additional, Antao, Olivia, additional, Weinstein, Jason S., additional, Damani-Yokota, Payal, additional, Khanna, Kamal, additional, Murray, Peter, additional, Rivera, Amariliz, additional, Siracusa, Mark C., additional, and Gause, William C., additional

Published
2020
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15. Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties

Author

Ural, Basak B., primary, Yeung, Stephen T., additional, Damani-Yokota, Payal, additional, Devlin, Joseph C., additional, de Vries, Maren, additional, Vera-Licona, Paola, additional, Samji, Tasleem, additional, Sawai, Catherine M., additional, Jang, Geunhyo, additional, Perez, Oriana A., additional, Pham, Quynh, additional, Maher, Leigh, additional, Loke, P'ng, additional, Dittmann, Meike, additional, Reizis, Boris, additional, and Khanna, Kamal M., additional

Published
2020
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16. REGULATION OF EXPRESSION OF THE  T CELL WC1 CO-RECEPTOR AND PATTERN RECOGNITION RECEPTOR MULTIGENE FAMILY

Author

Damani-Yokota, Payal

Abstract

WC1 molecules are hybrid PRR/co-receptors exclusively expressed on gd T cells of ruminants while humans and mice have related receptors. Bovine WC1 molecules bind pathogens directly and specifically and augment TCR-mediated signals. Using NGS, we found all 13 WC1 genes transcribed by blood gd T cells with no significant differences at birth although by adulthood the relative proportions of transcripts was somewhat altered perhaps attributable to immunological experience. WC1+ gd T cells form two main subpopulations in blood, WC1.1 and WC1.2, distinguished by reactivity with various anti-WC1 mAbs. Their WC1 molecules also differ in their ability to bind particular microbes suggesting the WC1 molecules expressed by a gd T cell may determine its antigen specificity. Although it was clear that the WC1+ subpopulations differed in WC1 gene expression we did not know the expression of WC1 genes by individual gd T cells. Thus 78 gd T cell clones from flow-cytometrically purified WC1+ subpopulations were generated and evaluated by qRT-PCR. The majority of gd T cell clones transcribed 1 to 4 WC1 genes and, while overlap of some transcripts occurred between the two subpopulations, 80% of clones that were generated in response to Leptospira stimulation had transcripts for a WC1 molecule known to bind Leptopsira which was significantly higher than for non-responsive clones We found WC1 molecules are not detected on thymocytes prior to the gd TCR and that the two WC1+ subpopulations are at a similar ratio in thymus as in blood. Using ChIP, we showed that Sox13, an important transcription factor for gd T cell development, differentially occupied WC1 gene loci in the WC1.1+ versus WC1.2+ cells. Using qRT-PCR and immunofluorescence, we evaluated transcription factors critical to development and effector functions of T lymphocytes as well as cytokines and the gd T cell subset marker CD27 in the two subpopulations. WC1.1+ cells showed significantly higher levels of transcription for CD27, as well as higher transcription and protein for Tbx21 and IFNg than WC1.2+ cells; the latter had higher levels of transcripts for Rorc and Il17a. This suggests a tendency for a Tgd1-like phenotype versus Tgd17-like phenotype, respectively.

Published
2018
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18. γδ T cells in livestock: Responses to pathogens and vaccine potential.

Author

Baldwin, Cynthia L., Yirsaw, Alehegne, Gillespie, Alexandria, Le Page, Lauren, Zhang, Fengqiu, Damani‐Yokota, Payal, and Telfer, Janice C.

Subjects
VACCINE effectiveness, PROTOZOAN diseases, T cells, LIVESTOCK, COMMUNICABLE diseases, VIRUS diseases
Abstract

The immediate objective of our research is to understand the molecular mechanisms underlying activation and potentiation of the protective functional response of WC1+ γδ T cells to pathogens afflicting livestock species. The long‐term goal is to incorporate stimulation of these cells into the next generation of vaccine constructs. γδ T cells have roles in the immune response to many infectious diseases including viral, bacterial, protozoan and worm infections, and their functional responses overlap with those of canonical αβ T cells, for example they produce cytokines including interferon‐γ and IL‐17. Stimulation of non‐conventional lymphocytes including γδ T cells and αβ natural killer T (NKT) cells has been shown to contribute to protective immunity in mammals, bridging the gap between the innate and adaptive immune responses. Because of their innate‐like early response, understanding how to engage γδ T‐cell responses has the potential to optimize strategies of those that aim to induce pro‐inflammatory responses as discussed here. [ABSTRACT FROM AUTHOR]

Published
2020
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