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4. miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, Colangelo, Tommaso, Guarize, Juliana, Dama, Elisa, Cocomazzi, Maria Pia, Mazzarelli, Francesco, Melocchi, Valentina, Palumbo, Orazio, Marino, Elena, Belloni, Elena, Montani, Francesca, Vecchi, Manuela, Barberis, Massimo, Graziano, Paolo, Pasquier, Andrea, Sanz-Ortega, Julian, Montuenga, Luis M., Carbonelli, Cristiano, Spaggiari, Lorenzo, and Bianchi, Fabrizio

Published
2022
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7. MicroRNAs and the Mediterranean diet: a nutri-omics perspective for lung cancer

Author

Cuttano, R, Mazzarelli, F, Afanga, K, Bianchi, F, Dama, E, Cuttano, Roberto, Mazzarelli, Francesco, Afanga, Kuku Miriam, Bianchi, Fabrizio, Dama, Elisa, Cuttano, R, Mazzarelli, F, Afanga, K, Bianchi, F, Dama, E, Cuttano, Roberto, Mazzarelli, Francesco, Afanga, Kuku Miriam, Bianchi, Fabrizio, and Dama, Elisa

Abstract

Lung cancer is the deadliest cancer type worldwide with ~ 1.8 million deaths per-year. Smoking accounts for ~ 85% of all cases, with a described joint effect with unhealthy diet in lung cancer risk increase. Public health policies to prevent carcinogens exposure, promote smoking cessation and advocacy for healthy nutrition, are therefore highly recommended. Here we have examined the benefits of the Mediterranean Diet (MedDiet) in protecting against some non-communicable diseases including lung cancer, highlighting the epidemiological and biomolecular aspects of MedDiet anti-inflammatory effect and its interaction with smoking habits closely linked to risk of lung cancer. Considering the high incidence and mortality rates of lung cancer, we discussed also about the global impact that a Planeterranean extension of the benefits of MedDiet could have on controlling lung cancer risk. We also debated the impact of personalized nutrition on lung cancer prevention, considering individual heterogeneity in response to diet plans as well as recent advancements on nutri-omics in lung cancer research, with a specific focus on the role of microRNAs (miRNAs) as a promising nutritional molecular hub for lung cancer prevention. We strongly believe that a deep understanding of the molecular link between food components and genetic/epigenetics factors can expand effective intervention strategies.

Published
2024

8. An in-silico analysis reveals further evidence of an aggressive subset of lung carcinoids sharing molecular features of high-grade neuroendocrine neoplasms

Author

Pelosi, G, Melocchi, V, Dama, E, Hofman, P, De Luca, M, Albini, A, Gemelli, M, Ricotta, R, Papotti, M, La Rosa, S, Uccella, S, Harari, S, Sonzogni, A, Asiedu, M, Wigle, D, Bianchi, F, Pelosi, Giuseppe, Melocchi, Valentina, Dama, Elisa, Hofman, Paul, De Luca, Marco, Albini, Adriana, Gemelli, Maria, Ricotta, Riccardo, Papotti, Mauro, La Rosa, Stefano, Uccella, Silvia, Harari, Sergio, Sonzogni, Angelica, Asiedu, Michael K, Wigle, Dennis A, Bianchi, Fabrizio, Pelosi, G, Melocchi, V, Dama, E, Hofman, P, De Luca, M, Albini, A, Gemelli, M, Ricotta, R, Papotti, M, La Rosa, S, Uccella, S, Harari, S, Sonzogni, A, Asiedu, M, Wigle, D, Bianchi, F, Pelosi, Giuseppe, Melocchi, Valentina, Dama, Elisa, Hofman, Paul, De Luca, Marco, Albini, Adriana, Gemelli, Maria, Ricotta, Riccardo, Papotti, Mauro, La Rosa, Stefano, Uccella, Silvia, Harari, Sergio, Sonzogni, Angelica, Asiedu, Michael K, Wigle, Dennis A, and Bianchi, Fabrizio

Abstract

Little is known as to whether there may be any pathogenetic link between pulmonary carcinoids and neuroendocrine carcinomas (NECs). A gene signature we previously found to cluster pulmonary carcinoids, large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC), and which encompassed MEN1, MYC, MYCL1, RICTOR, RB1, SDHA, SRC and TP53 mutations or copy number variations (CNVs), was used to reclassify an independent cohort of 54 neuroendocrine neoplasms (NENs) [31 typical carcinoids (TC), 11 atypical carcinoids (AC) and 12 SCLC], by means of transcriptome and mutation data. Unsupervised clustering analysis identified two histology-independent clusters, namely CL1 and CL2, where 17/42 (40.5%) carcinoids and all the SCLC samples fell into the latter. CL2 carcinoids affected survival adversely, were enriched in T to G transversions or T > C/C > T transitions in the context of specific mutational signatures, presented with at least 1.5-fold change (FC) increase of gene mutations including TSC2, SMARCA2, SMARCA4, ERBB4 and PTPRZ1, differed for gene expression and showed epigenetic changes in charge of MYC and MTORC1 pathways, cellular senescence, inflammation, high-plasticity cell state and immune system exhaustion. Similar results were also found in two other independent validation sets comprising 101 lung NENs (24 carcinoids, 21 SCLC and 56 LCNEC) and 30 carcinoids, respectively. We herein confirmed an unexpected sharing of molecular traits along the spectrum of lung NENs, with a subset of genomically distinct aggressive carcinoids sharing molecular features of high-grade neuroendocrine neoplasms.

Published
2024

9. Single-cell RNA-seq analysis of human lung adenocarcinoma unveil mechanisms of epithelial cell plasticity which drive tumor progression

Author

Melocchi, V, Dama, E, Mazzarelli, F, Afanga, M, Cuttano, R, Bianchi, F, Melocchi Valentina, Dama Elisa, Mazzarelli Francesco, Afanga Miriam Kuku, Cuttano Roberto, Bianchi Fabrizio, Melocchi, V, Dama, E, Mazzarelli, F, Afanga, M, Cuttano, R, Bianchi, F, Melocchi Valentina, Dama Elisa, Mazzarelli Francesco, Afanga Miriam Kuku, Cuttano Roberto, and Bianchi Fabrizio

Published
2024

10. Combined analysis of miR-200 family and its significance for breast cancer

Author

Fontana, Andrea, Barbano, Raffaela, Dama, Elisa, Pasculli, Barbara, Rendina, Michelina, Morritti, Maria Grazia, Melocchi, Valentina, Castelvetere, Marina, Valori, Vanna Maria, Ravaioli, Sara, Bravaccini, Sara, Ciuffreda, Luigi, Graziano, Paolo, Maiello, Evaristo, Copetti, Massimiliano, Fazio, Vito Michele, Esteller, Manel, Bianchi, Fabrizio, and Parrella, Paola

Published
2021
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11. Most high-grade neuroendocrine tumours of the lung are likely to secondarily develop from pre-existing carcinoids: innovative findings skipping the current pathogenesis paradigm

Author

Pelosi, Giuseppe, Bianchi, Fabrizio, Dama, Elisa, Simbolo, Michele, Mafficini, Andrea, Sonzogni, Angelica, Pilotto, Sara, Harari, Sergio, Papotti, Mauro, Volante, Marco, Fontanini, Gabriella, Mastracci, Luca, Albini, Adriana, Bria, Emilio, Calabrese, Fiorella, and Scarpa, Aldo

Published
2018
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12. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, Carla Maria Irene, primary, Dama, Elisa, additional, Maggi, Michele, additional, Feragalli, Beatrice, additional, Borelli, Cristina, additional, Del Colle, Anna, additional, Taurchini, Marco, additional, Maiello, Evaristo, additional, De Cosmo, Salvatore, additional, Lacedonia, Donato, additional, Barbaro, Maria Pia Foschino, additional, Carpagnano, Giovanna Elisiana, additional, Scioscia, Giulia, additional, Graziano, Paolo, additional, Termine, Rosalinda, additional, Frongillo, Elisabettamaria, additional, Santamaria, Sonia, additional, Venuti, Mariapia, additional, Grimaldi, Maria Arcangela, additional, Notarangelo, Stefano, additional, Saponara, Annarita, additional, Copetti, Massimiliano, additional, Colangelo, Tommaso, additional, Cuttano, Roberto, additional, Macrodimitris, Dimitrios, additional, Mazzarelli, Francesco, additional, Talia, Michela, additional, Mirijello, Antonio, additional, Pazienza, Luca, additional, Perna, Rita, additional, Simeone, Anna, additional, Vergara, Doriana, additional, Varriale, Antonio, additional, Carella, Massimo, additional, Bianchi, Fabrizio, additional, and Sperandeo, Marco, additional

Published
2023
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13. Further evidence of an evolutionary continuum from a subset of lung carcinoids to aggressive neuroendocrine tumors

Author

Pelosi, Giuseppe, primary, Melocchi, Valentina, additional, Dama, Elisa, additional, Hofman, Paul, additional, De Luca, Marco, additional, Albini, Adriana, additional, Gemelli, Maria, additional, Ricotta, Riccardo, additional, Papotti, Mauro, additional, Rosa, Stefano La, additional, Uccella, Silvia, additional, Harari, Sergio, additional, Asiedu, Michael, additional, Wigle, Dennis, additional, and Bianchi, Fabrizio, additional

Published
2023
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14. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, Sperandeo, Marco, Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, Sperandeo, M, Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, and Sperandeo, Marco

Abstract

Objectives: We validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose. Methods: From July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan. Results: On a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity

Published
2023

15. Additional file 9 of miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, Colangelo, Tommaso, Guarize, Juliana, Dama, Elisa, Cocomazzi, Maria Pia, Mazzarelli, Francesco, Melocchi, Valentina, Palumbo, Orazio, Marino, Elena, Belloni, Elena, Montani, Francesca, Vecchi, Manuela, Barberis, Massimo, Graziano, Paolo, Pasquier, Andrea, Sanz-Ortega, Julian, Montuenga, Luis M., Carbonelli, Cristiano, Spaggiari, Lorenzo, and Bianchi, Fabrizio

Abstract

Additional file 9. Figure S5. Higher basal levels of PD-L1 are associated to cisplatin resistance in NSCLC in vitro.

Published
2023
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16. Additional file 7 of miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, Colangelo, Tommaso, Guarize, Juliana, Dama, Elisa, Cocomazzi, Maria Pia, Mazzarelli, Francesco, Melocchi, Valentina, Palumbo, Orazio, Marino, Elena, Belloni, Elena, Montani, Francesca, Vecchi, Manuela, Barberis, Massimo, Graziano, Paolo, Pasquier, Andrea, Sanz-Ortega, Julian, Montuenga, Luis M., Carbonelli, Cristiano, Spaggiari, Lorenzo, and Bianchi, Fabrizio

Abstract

Additional file 7. Figure S3. Implantation analysis of CDX in zebrafish.

Published
2023
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17. Additional file 15 of miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, Colangelo, Tommaso, Guarize, Juliana, Dama, Elisa, Cocomazzi, Maria Pia, Mazzarelli, Francesco, Melocchi, Valentina, Palumbo, Orazio, Marino, Elena, Belloni, Elena, Montani, Francesca, Vecchi, Manuela, Barberis, Massimo, Graziano, Paolo, Pasquier, Andrea, Sanz-Ortega, Julian, Montuenga, Luis M., Carbonelli, Cristiano, Spaggiari, Lorenzo, and Bianchi, Fabrizio

Abstract

Additional file 15. Figure S11. miR-455-5p is not involved in the regulation of NOTCH-1 and HOXA-AS3 expression in NSCLC.

Published
2023
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18. Additional file 6 of miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, Colangelo, Tommaso, Guarize, Juliana, Dama, Elisa, Cocomazzi, Maria Pia, Mazzarelli, Francesco, Melocchi, Valentina, Palumbo, Orazio, Marino, Elena, Belloni, Elena, Montani, Francesca, Vecchi, Manuela, Barberis, Massimo, Graziano, Paolo, Pasquier, Andrea, Sanz-Ortega, Julian, Montuenga, Luis M., Carbonelli, Cristiano, Spaggiari, Lorenzo, and Bianchi, Fabrizio

Abstract

Additional file 6. Figure S2. Biological characterization of Cisplatin resistant cells.

Published
2023
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19. Additional file 5 of miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, Colangelo, Tommaso, Guarize, Juliana, Dama, Elisa, Cocomazzi, Maria Pia, Mazzarelli, Francesco, Melocchi, Valentina, Palumbo, Orazio, Marino, Elena, Belloni, Elena, Montani, Francesca, Vecchi, Manuela, Barberis, Massimo, Graziano, Paolo, Pasquier, Andrea, Sanz-Ortega, Julian, Montuenga, Luis M., Carbonelli, Cristiano, Spaggiari, Lorenzo, and Bianchi, Fabrizio

Abstract

Additional file 5. Figure S1. Whole miRNA expression profile of chemo-naïve metastatic tissue from stage III NSCLC patients.

Published
2023
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20. Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)

Author

Quarato, Carla Maria Irene, Dama, Elisa, Maggi, Michele, Feragalli, Beatrice, Borelli, Cristina, Del Colle, Anna, Taurchini, Marco, Maiello, Evaristo, De Cosmo, Salvatore, Lacedonia, Donato, Barbaro, Maria Pia Foschino, Carpagnano, Giovanna Elisiana, Scioscia, Giulia, Graziano, Paolo, Termine, Rosalinda, Frongillo, Elisabettamaria, Santamaria, Sonia, Venuti, Mariapia, Grimaldi, Maria Arcangela, Notarangelo, Stefano, Saponara, Annarita, Copetti, Massimiliano, Colangelo, Tommaso, Cuttano, Roberto, Macrodimitris, Dimitrios, Mazzarelli, Francesco, Talia, Michela, Mirijello, Antonio, Pazienza, Luca, Perna, Rita, Simeone, Anna, Vergara, Doriana, Varriale, Antonio, Carella, Massimo, Bianchi, Fabrizio, Sperandeo, Marco, Quarato, C, Dama, E, Maggi, M, Feragalli, B, Borelli, C, Del Colle, A, Taurchini, M, Maiello, E, De Cosmo, S, Lacedonia, D, Barbaro, M, Carpagnano, G, Scioscia, G, Graziano, P, Termine, R, Frongillo, E, Santamaria, S, Venuti, M, Grimaldi, M, Notarangelo, S, Saponara, A, Copetti, M, Colangelo, T, Cuttano, R, Macrodimitris, D, Mazzarelli, F, Talia, M, Mirijello, A, Pazienza, L, Perna, R, Simeone, A, Vergara, D, Varriale, A, Carella, M, Bianchi, F, and Sperandeo, M

Subjects
ransthoracic ultrasound, high-resolution computed tomography, lung cancer, interstitial lung abnormalities, screening protocol, environmental exposure, lung cancer, interstitial lung abnormalities, high-resolution computed tomography, screening protocol, ransthoracic ultrasound, environmental exposure, transthoracic ultrasound, General Medicine, interstitial lung abnormalitie
Abstract

ObjectivesWe validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a population of asymptomatic high-risk subjects for interstitial lung abnormalities (ILA) and lung cancer. Due to heavy environmental pollution burden, the district Tamburi of Taranto has been chosen as “case study” for this purpose.MethodsFrom July 2018 to October 2020, 677 patients aged between 45 and 65 year and who had been living in the Tamburi district of Taranto for at least 10 years were included in the study. After demographic, clinical and risk factor exposition data were collected, each participant underwent a complete TUS examination. These subjects were then asked to know if they agreed to perform a second-level examination by low-dose HRCT scan.ResultsOn a total of 167 subjects (24.7%) who agreed to undergo a second-level HRCT, 85 patients (50.9%) actually showed pleuro-pulmonary abnormalities. Interstitial abnormalities were detected in a total of 36 patients on HRCT scan. In particular, 34 participants presented subpleural ILAs, that were classified in the fibrotic subtype in 7 cases. The remaining 2 patients showed non-subpleural interstitial abnormalities. Subpleural nodules were observed in 46 patients. TUS showed an overall diagnostic accuracy of 88.6% in detecting pleuro-pulmonary abnormalities in comparison with HRCT scan, with a sensitivity of 95.3%, a specificity of 81.7%, a positive predictive value of 84.4% and a negative predictive value of 94.4%. The matched evaluation of specific pulmonary abnormalities on HRTC scan (i.e., interstitial abnormalities or pulmonary nodules) with determinate sonographic findings revealed a reduction in both TUS sensibility and specificity. Focusing TUS evaluation on the assessment of interstitial abnormalities, a thickened pleural line showed a sensitivity of 63.9% and a specificity of 69.5%, hypoechoic striae showed a sensitivity of 38.9% and a specificity of 90.1% and subpleural nodules showed a sensitivity of 58.3% and a specificity of 77.1%. Regarding to the assessment of subpleural nodules, TUS showed a sensitivity of 60.9% and a specificity of 81.0%. However, the combined employment of TUS examination and HRCT scans allowed to identify 34 patients with early subpleural ILA and to detect three suspicious pulmonary nodules (of which two were intraparenchymal and one was a large subpleural mass), which revealed to be lung cancers on further investigations.ConclusionA first-line TUS examination might aid the identification of subjects highly exposed to environmental pollution, who could benefit of a second-line low-dose HRCT scan to find early interstitial lung diseases as well as lung cancer.Protocol registration codePLEURO-SCREENING-V1.0_15 Feb, 17.

Published
2023

21. Additional file 8 of miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, Colangelo, Tommaso, Guarize, Juliana, Dama, Elisa, Cocomazzi, Maria Pia, Mazzarelli, Francesco, Melocchi, Valentina, Palumbo, Orazio, Marino, Elena, Belloni, Elena, Montani, Francesca, Vecchi, Manuela, Barberis, Massimo, Graziano, Paolo, Pasquier, Andrea, Sanz-Ortega, Julian, Montuenga, Luis M., Carbonelli, Cristiano, Spaggiari, Lorenzo, and Bianchi, Fabrizio

Abstract

Additional file 8. Figure S4. miR-455-5p overexpression decreases the proliferation rate of NSCLC cells.

Published
2023
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22. miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

Author

Cuttano, Roberto, primary, Colangelo, Tommaso, additional, Guarize, Juliana, additional, Dama, Elisa, additional, Cocomazzi, Maria Pia, additional, Mazzarelli, Francesco, additional, Melocchi, Valentina, additional, Palumbo, Orazio, additional, Marino, Elena, additional, Belloni, Elena, additional, Montani, Francesca, additional, Vecchi, Manuela, additional, Barberis, Massimo, additional, Graziano, Paolo, additional, Pasquier, Andrea, additional, Sanz-Ortega, Julian, additional, Montuenga, Luis M., additional, Carbonelli, Cristiano, additional, Spaggiari, Lorenzo, additional, and Bianchi, Fabrizio, additional

Published
2022
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23. Integrated molecular profiling of patient‐derived ovarian cancer models identifies clinically relevant signatures and tumor vulnerabilities

Author

Lupia, Michela, primary, Melocchi, Valentina, additional, Bizzaro, Francesca, additional, Lo Riso, Pietro, additional, Dama, Elisa, additional, Baronio, Micol, additional, Ranghiero, Alberto, additional, Barberis, Massimo, additional, Bernard, Loris, additional, Bertalot, Giovanni, additional, Giavazzi, Raffaella, additional, Testa, Giuseppe, additional, Bianchi, Fabrizio, additional, and Cavallaro, Ugo, additional

Published
2022
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25. miR-Test: A Blood Test for Lung Cancer Early Detection

Author

Montani, Francesca, Marzi, Matteo Jacopo, Dezi, Fabio, Dama, Elisa, Carletti, Rose Mary, Bonizzi, Giuseppina, Bertolotti, Raffaella, Bellomi, Massimo, Rampinelli, Cristiano, Maisonneuve, Patrick, Spaggiari, Lorenzo, Veronesi, Giulia, Nicassio, Francesco, Di Fiore, Pier Paolo, and Bianchi, Fabrizio

Published
2015
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39. Most high-grade neuroendocrine tumours of the lung are likely to secondarily develop from pre-existing carcinoids: innovative findings skipping the current pathogenesis paradigm

Author

Pelosi, G, Bianchi, F, Dama, E, Simbolo, M, Mafficini, A, Sonzogni, A, Pilotto, S, Harari, S, Papotti, M, Volante, M, Fontanini, G, Mastracci, L, Albini, A, Bria, E, Calabrese, F, Scarpa, A, Pelosi, Giuseppe, Bianchi, Fabrizio, Dama, Elisa, Simbolo, Michele, Mafficini, Andrea, Sonzogni, Angelica, Pilotto, Sara, Harari, Sergio, Papotti, Mauro, Volante, Marco, Fontanini, Gabriella, Mastracci, Luca, Albini, Adriana, Bria, Emilio, Calabrese, Fiorella, Scarpa, Aldo, Pelosi, G, Bianchi, F, Dama, E, Simbolo, M, Mafficini, A, Sonzogni, A, Pilotto, S, Harari, S, Papotti, M, Volante, M, Fontanini, G, Mastracci, L, Albini, A, Bria, E, Calabrese, F, Scarpa, A, Pelosi, Giuseppe, Bianchi, Fabrizio, Dama, Elisa, Simbolo, Michele, Mafficini, Andrea, Sonzogni, Angelica, Pilotto, Sara, Harari, Sergio, Papotti, Mauro, Volante, Marco, Fontanini, Gabriella, Mastracci, Luca, Albini, Adriana, Bria, Emilio, Calabrese, Fiorella, and Scarpa, Aldo

Abstract

Among lung neuroendocrine tumours (Lung-NETs), typical carcinoid (TC) and atypical carcinoid (AC) are considered separate entities as opposed to large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). By means of two-way clustering analysis of previously reported next-generation sequencing data on 148 surgically resected Lung-NETs, six histology-independent clusters (C1 → C6) accounting for 68% of tumours were identified. Low-grade Lung-NETs were likely to evolve into high-grade tumours following two smoke-related paths. Tumour composition of the first path (C5 → C1 → C6) was coherent with the hypothesis of an evolution of TC to LCNEC, even with a conversion of SCLC-featuring tumours to LCNEC. The second path (C4 → C2-C3) had a tumour composition supporting the evolution of AC to SCLC-featuring tumours. The relevant Ki-67 labelling index varied accordingly, with median values being 5%, 9% and 50% in the cluster sequence C5 → C1 → C6, 12% in cluster C4 and 50-60% in cluster C2-C3. This proof-of-concept study suggests an innovative view on the progression of pre-existing TC or AC to high-grade NE carcinomas in most Lung-NET instances

Published
2018

41. An Aggressive Subtype of Stage I Lung Adenocarcinoma with Molecular and Prognostic Characteristics Typical of Advanced Lung Cancers

Author

Dama, Elisa, primary, Melocchi, Valentina, additional, Dezi, Fabio, additional, Pirroni, Stefania, additional, Carletti, Rose Mary, additional, Brambilla, Daniela, additional, Bertalot, Giovanni, additional, Casiraghi, Monica, additional, Maisonneuve, Patrick, additional, Barberis, Massimo, additional, Viale, Giuseppe, additional, Vecchi, Manuela, additional, Spaggiari, Lorenzo, additional, Bianchi, Fabrizio, additional, and Di Fiore, Pier Paolo, additional

Published
2017
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42. Sensitive and affordable diagnostic assay for the quantitative detection of anaplastic lymphoma kinase (ALK) alterations in patients with non-small cell lung cancer

Author

Dama, Elisa, primary, Tillhon, Micol, additional, Bertalot, Giovanni, additional, de Santis, Francesca, additional, Troglio, Flavia, additional, Pessina, Simona, additional, Passaro, Antonio, additional, Pece, Salvatore, additional, de Marinis, Filippo, additional, Dell’Orto, Patrizia, additional, Viale, Giuseppe, additional, Spaggiari, Lorenzo, additional, Di Fiore, Pier Paolo, additional, Bianchi, Fabrizio, additional, Barberis, Massimo, additional, and Vecchi, Manuela, additional

Published
2016
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43. Optimization and Standardization of Circulating MicroRNA Detection for Clinical Application: The miR-Test Case

Author

Marzi, Matteo Jacopo, primary, Montani, Francesca, primary, Carletti, Rose Mary, primary, Dezi, Fabio, primary, Dama, Elisa, primary, Bonizzi, Giuseppina, primary, Sandri, Maria Teresa, primary, Rampinelli, Cristiano, primary, Bellomi, Massimo, primary, Maisonneuve, Patrick, primary, Spaggiari, Lorenzo, primary, Veronesi, Giulia, primary, Bianchi, Fabrizio, primary, Di Fiore, Pier Paolo, primary, and Nicassio, Francesco, primary

Published
2016
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44. Marriage and parenthood among subjects cured of childhood cancer: a report from the Italian AIEOP Off-Therapy Registry

Author

Pivetta, EMANUELE EMILIO, Maule, MILENA MARIA, Pisani, Paola, Zugna, Daniela, Haupt, R, Jankovic, M, Arico', M, Casale, F, Clerico, A, CORDERO DI MONTEZEMOLO, Luca, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, Mg, Dama, Elisa, Magnani, C, Merletti, Franco, Pastore, G., Pivetta E., Maule MM., Pisani P., Zugna D., Haupt R., Jankovic M., Arico' M., Casale F., Clerico A., Cordero di Montezemolo L., Kiren V., Locatelli F., Palumbo G., Pession A., Pillon M., Santoro N., Terenziani M., Valsecchi MG., Dama E., Magnani C., Merletti F., Pastore G., Pivetta, E, Maule, Mm, Pisani, P, Zugna, D, Haupt, R, Jankovic, M, Aricò, M, Casale, Fiorina, Clerico, A, CORDERO DI MONTEZEMOLO, L, Kiren, V, Locatelli, F, Palumbo, G, Pession, A, Pillon, M, Santoro, N, Terenziani, M, Valsecchi, Mg, Dama, E, Magnani, C, Merletti, F, and Pastore, G.

Subjects
Quality of life, Fertility, childhood cancer, Marriage, Long-term survivors, childhood cancer, marriage, fertility, long-term survivors, quality of life
Abstract

The aim of this study was to describe the patterns of marriage and parenthood in a cohort of childhood cancer survivors included in the Off-Therapy Registry maintained by the Italian Association of Pediatric Hematology and Oncology. Design and Methods We analyzed a cohort of 6,044 patients diagnosed with cancer between 1960 and 1998, while aged 0 to 14 years and who were 18 years old or older by December 2003. They were followed up through the regional vital statistics registers until death or the end of follow up (October 30, 2006), whichever occurred first, and their marital status and date of birth of their children were recorded. The cumulative probabilities of being married and having a first child were computed by gender and compared by tumor type within the cohort. Marriage and fertility rates (the latter defined as the number of live births per woman-year) were compared with those of the Italian population of the same age, gender, area of residence and calendar period by means of the observed to expected (O/E) ratios. Results During the follow-up period, 4,633 (77%) subjects had not married. The marriage O/E ratios were 0.56 (95% CI: 0.51-0.61) and 0.70 (95% CI: 0.65-0.76) among men and women, respectively. Overall, 263 men had 367 liveborn children, and 473 women had 697 liveborn children. The female fertility O/E ratio was 0.57 (95% CI: 0.53-0.62) overall, and 1.08 (95% CI: 0.99-1.17) when analyses were restricted to married/cohabiting women Conclusions Childhood cancer survivors are less likely to marry and to have children than the general population, confirming the life-long impact of their previous disease on their social behavior and choices. The inclusion of counseling in the strategies of management and long-term surveillance of childhood cancer patients could be beneficial to survivors as they approach adulthood.

Published
2011

45. Abstract 1573: miR-Test: a blood test for lung cancer early detection

Author

Montani, Francesca, primary, Marzi, Matteo Jacopo, additional, Dezi, Fabio, additional, Dama, Elisa, additional, Carletti, Rose Mary, additional, Bonizzi, Giuseppina, additional, Bertolotti, Raffaella, additional, Bellomi, Massimo, additional, Rampinelli, Cristiano, additional, Maisonneuve, Patrick, additional, Spaggiari, Lorenzo, additional, Veronesi, Giulia, additional, Nicassio, Francesco, additional, Di Fiore, Pier Paolo, additional, and Bianchi, Fabrizio, additional

Published
2015
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47. Abstract 233: Mining cancer gene expression databases for latent information on intronic microRNAs

Author

Monterisi, Simona, primary, D'Ario, Giovanni, additional, Dama, Elisa, additional, Rotmensz, Nicole, additional, Confalonieri, Stefano, additional, Tordonato, Chiara, additional, Troglio, Flavia, additional, Bertalot, Giovanni, additional, Maisonneuve, Patrick, additional, Viale, Giuseppe, additional, Nicassio, Francesco, additional, Di Fiore, Pier Paolo, additional, and Bianchi, Fabrizio, additional

Published
2015
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48. [New incidence and mortality data. 2003-2005]

Author

Airtum, Working Group, Crocetti, Emanuele, Buzzoni, Carlotta, Serraino, Diego, Vicario, Gianni, Angelin, Tiziana, Bessega, Giuseppina, Bidoli, Ettore, Brunetti, Davide, Dottori, Margherita, Forgiarini, Ornella, French, Susan, Stanta, Giorgio, Zaina, Lucia, Zanier, Loris, Zambon, Paola, Baracco, Maddalena, Bovo, Emanuela, Dal Cin, Antonella, Fiore, Anna Rita, Greco, Alessandra, Guzzinati, Stefano, Monetti, Daniele, Rosano, Alberto, Stocco, Carmen Fiorella, Tognazzo, Sandro, Egarter-Vigl, Eduard, Bello, Francesco, Vittadello, Fabio, Bulatko, Andreas, Luthy, Monika, Facchinelli, Gerlinde, Valiere, Elena, Tschugguel, Birgit, Dorfmann, Hubert, Giacomin, Adriano, Vercellino, Pier Carlo, Andreone, Simona, Ferretti, Stefano, Marzola, Laura, Migliari, Elena, Carletti, Nada, Nenci, Italo, Vitarelli, Susanna, Antonini, Silvia, Federico, Massimo, Artioli, Maria Elisa, Cirilli, Claudia, Fracca, Antonella, Rashid, Ivan, Valla, Katia, Lisi, Vincenzo, Sgargi, Paolo, Bozzani, Francesco, Donato, Andrea, Iannelli, Arturo, Mari, Carmine, Senatore, Gennaro, Zevola, Arrigo, Abbamonte, Benedetto, Alfano, Ida An, Annunziato, Loredana, Barone, Savino, Ferrante, Assunta, Budroni, Mario, Cesaraccio, Rosaria, Pirino, Daniela, Sechi, Ornelia, Piras, Daniela, Sechi, Amelia, Oggiano, Massimiliano, Piffer, Silvano, Franchini, Silva, Gentilini, Maria A., Battisti, Laura, Cappelletti, Maddalena, Falcini, Fabio, Amadori, Dino, Balducci, Chiara, Benericetti, Elisa, Bucchi, Lauro, Caprara, Licia, Colamartini, Americo, Cordaro, Carlo, Desiderio, Franco, Fabbri, Carla, Foca, Flavia, Giorgetti, Stefania, Montanari, Emanuela, Naldi, Stefania, Nannini, Roberto, Ravaioli, Alessandra, Ravegnani, Mila, Rinaldi, Elisa, Salvatore, Silvia, Serafini, Monica, Vattiato, Rosa, Vitali, Benedetta, Pannozzo, Fabio, Busco, Susanna, Natali, Maurilio, Valerio Ramazzotti, Macci, Leonarda, Bugliarello, Ester, Bernazza, Edvige, Tamburo, Lucilla, Rossi, Miriana, Curatella, Simonetta, Sperduti, Isabella, Fusco, Mario, Bellatalla, Caterina, Fusco, Maria, Panico, Margherita, Perrotta, Carmela, Vassante, Biagio, Crosignani, Paolo, Tagliabue, Giovanna, Contiero, Paolo, Fabiano, Sabrina, Maghini, Anna, Tittarelli, Andrea, Codazzi, Tiziana, Frassoldi, Emanuela, Costa, Enrica, Nobile, Silvia, Vigano, Clotilde, Berrino, Franco, Mangone, Lucia, Pezzarossi, Annamaria, Pellegri, Carlotta, Caroli, Stefania, Valentini, Massimo, Cavuto, Silvio, Felice, Enza, Vercelli, Marina, Orengo, Maria Antonietta, Casella, Claudia, Marani, Enza, Puppo, Antonella, Celesia, Maria Vittoria, Cogno, Roberta, Grondona, Anna Maria, Giachero, Giovanna, Manenti, Simone, Quaglia, Alberto, Garrone, Elsa, Paci, Eugenio, Caldarella, Adele, Corbinelli, Antonella, Dainelli, Giulia, Guadagni, Marzia, Intrieri, Teresa, Manneschi, Gianfranco, Miccinesi, Guido, Nemcova, Libuse, Sacchettini, Claudio, Giusti, Francesco, La Rosa, Francesco, Stracci, Fabrizio, Petrinelli, Anna Maria, Costarelli, Daniela, Cassetti, Tiziana, Scheibel, Massimo, Romagnoli, Carlo, Mastrandrea, Vito, Zanetti, Roberto, Rosso, Stefano, Patriarca, Silvia, Vicari, Piera, Sobrato, Irene, Gilardi, Franca, Maglietta, Giusy, Gallesio, Luisa, Tumino, Rosario, Cilia, Sonia, La Rosa, Maria Guglielmina, Cascone, Giuseppe, Cianciolo, Giuseppe, Frasca, Graziella, Giurdanella, Maria Concetta, Martorana, Caterina, Morana, Gabriele, Nicita, Carmela, Rollo, Patrizia, Ruggeri, Maria Grazia, Sigona, Aurora, Spata, Eugenia, Vacirca, Stefania, Bisanti, Luigi, Autelitano, Mariangela, Ghilardi, Simona, Bovini, Annamaria, Giubelli, Cinzia, Tessandori, Roberto, Ardemagni, Giuseppina, Traina, Adele, Candela, Pina, Contrino, Maria Lia, Tisano, Francesco, Madeddu, Anselmo, Ponz Leon, Maurizio, Di Gregorio, Carmela, Roncucci, Luca, Benfatti, Piero, Losi, Lorena, Ponti, Giovanni, Pedroni, Monica, Rossi, Giuseppina, Roncari, Barbara, Maffei, Stefania, Menigatti, Mirco, Rossi, Federica, Pecone, Luana, Domati, Federica, Pastore, Guido, Magnani, Corrado, Terracini, Benedetto, Alessi, Daniela, Dal Masso, Paola, Dama, Elisa, Macerata, Vanda, Maule, Milena, Mosso, Maria Luisa, Nonnato, Marinella, Zuccolo, Luisa, Merletti, Franco, Pannelli, Franco, Pascucci, Cristiana, Gennaro, Valerio, Benfatto, Lucia, Bianchelli, Monica, Lazzarotto, Anna, and Viarengo, Paolo

Subjects
Male, colorectal tumors, Italy, Incidence, Neoplasms, mortality, incidence, Prevalence, Humans, Female
Abstract

This is an update of incidence and mortality cancer data provided by the Italian Network of Cancer Registry (AIRTUM) relative to the period 2003-2005.AIRTUM is a network of general and specialized population-based cancer registries that covers about 1/3 of the Italian resident population (www.registri-tumori.it). Incidence and mortality data for the period 2003-2005 are based on 20 Registries. The five most frequently diagnosed cancers were: - prostate (18.5%), non melanoma skin (15.8%), lung (13.1%), colorectal (12.0%), bladder (5.7%) among males; - breast (24.9%), non melanoma skin (15.1%), colorectal (11.9%), lung (5.0%) and stomach (4.1%) among females. In the same period the most frequent causes of cancer death were: - cancer of the lung (27.6%), colorectal (10.7%), prostate (8.5%), stomach (7.3%) and liver (6.1%) among males; - breast cancer (16.3%), colorectal (11.9%), lung (10.3%), stomach (7.2%) and pancreas (6.5%) among females. According to the age-specific incidence rates one man and one woman every two will receive a cancer diagnosis during his/hers life (from birth to the age of 84 years). From 1993-1995 to 2003-2005, overall crude cancer incidence rate (males and females together) increased from 555.4 to 654.8 x 100,000. Standardization showed that 63% of this increase was due to ageing of the population. Moreover, most of the residual increase was among those cancer sites (breast, prostate, colorectal, thyroid and melanoma) for which early detection may have played a relevant role in anticipating (and therefore increasing) the number of diagnoses. Due to population ageing also overall cancer mortality did not show any decrease when crude rates were compared. On the contrary, standardized mortality rates (all cancers together) showed a strong decrease (311.4 vs. 266.5 x 100.000). The risk of receiving a diagnosis or dying because of cancer is still lower in residents in the regions of the South of Italy than in those of Central and Northern Italy, but they are becoming more and more similar. In Italy cancer incidence and mortality rates are similar to those in northern European countries and in USA among males, but they are still lower for women.

Published
2009

50. Mining cancer gene expression databases for latent information on intronic microRNAs

Author

Monterisi, Simona, primary, D'Ario, Giovanni, additional, Dama, Elisa, additional, Rotmensz, Nicole, additional, Confalonieri, Stefano, additional, Tordonato, Chiara, additional, Troglio, Flavia, additional, Bertalot, Giovanni, additional, Maisonneuve, Patrick, additional, Viale, Giuseppe, additional, Nicassio, Francesco, additional, Vecchi, Manuela, additional, Di Fiore, Pier Paolo, additional, and Bianchi, Fabrizio, additional

Published
2014
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