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The synthesis of the novel ligand terpyridine-pincer (3, TPBr) and the first examples of its coordination chemistry are described. The analysis has indicated that the results are in line with a weak coupling between the {Ru(tpy)(sub 2)} chromophoric unit and the (non)metalated NCN-pincer moiety.

A general approach is described for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. The studies have shown that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population.

A novel method is described for the efficient discovery of new types of minor actinide (MA) ligands, which is based on the unique combination of tea bag split pool combinatorial chemistry and screening based on the inherent radioactivity of the complexed cations. The method has also allowed the competitive screening of multiple nuclides that can be quantified by their radioactive emission spectrum.

We demonstrate highly-efficient, solution-processed small molecule solar cells with the best power conversion efficiency (PCE) of more than 5%. The active layer consists of a diketopyrrolopyrrole-based donor molecule (DPP(TBFu)2) and a fullerene derivative (PC71BM) that is spin cast and subsequently treated with solvent vapor annealing (SVA) in air. We find not all solvent vapors lead to the best PCE. Solvents of high vapor pressures and medium donor solubilities, such as tetrahydrofuran or carbon disulfide, are most suitable for SVA in the context of organic solar cell application. On the other hand, acceptor solubility plays an insignificant role in such a treatment. An active layer treated with ideal solvent vapors develops desirable phase separation in both lateral and vertical directions, as revealed by AFM, TEM and TEM tomography. The SVA also leads to enhanced hole mobility. We believe the fast SVA treatment performed in air is a viable way to tune the active layer morphology for printed solar cells. [ABSTRACT FROM AUTHOR]

We report the preparation of degradable capsules vialayer-by-layerassembly using polyelectrolyte (PE) polyrotaxanes (PRXs). The PRXcapsules were prepared by the sequential deposition of PRXs onto silicaparticles followed by the dissolution of the silica cores. The colloidalstability of the PRX capsules that are formed depends on the salt/buffersolution used in the assembly process. Various salt/buffer combinationswere examined to avoid aggregation of the core–shell particlesduring PRX assembly and core dissolution. Using appropriate assemblyconditions, we prepared colloidally stable, robust capsules. PRX capsulesconsisting of eight layers of PE PRXs had a wall thickness of ∼15nm. The degradation of the PRX capsules was demonstrated through thedisassembly of the PE PRXs using glutathione, which cleaves the disulfidebonds linking the end-capping groups of the PE PRXs. Given the supramolecularnoncovalent structure of PRXs and their adjustable properties, itis expected that PRXs will be used as building blocks for assemblingadvanced capsules with unique and tailored properties. [ABSTRACT FROM AUTHOR]

Abstract: A screening method for parallel Am3+ ligand libraries is presented. The method makes use of α-radiation in combination with a photographic film to detect the complexed Am3+. After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am3+. This allows a fast discrimination between the Am3+ complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5Bq 241Am can be detected. Using internal standards a semi-quantitative assessment can be performed. [Copyright &y& Elsevier]

Thermodynamically assembled core-shell nanocarriers are potential candidates for drug delivery applications due to their submicrometer size and the ability to load drugs into their hydrophobic core. Herein, we describe the formation of core-shell particles that consist of noncovalent polymers, that is, polyrotaxanes (PRXs), that form an α-cyclodextrin (αCD) core surrounded by a corona of low-fouling poly(ethylene glycol) (PEG). The PRX core-shell particles are able to sequester small organic molecules, such as pyrene and calcein, releasing these small molecules during degradation. The small, cellular peptide, glutathione, was used to degrade the particles through the reductive cleavage of disulfide bonds that stabilize the individual PRX polymers. Cleavage of a single bond allows for the degradation of the supramolecular-polymer, making these PRX core-shell particles highly responsive. Furthermore, these particles demonstrate negligible cytotoxicity in mammalian cells, making them promising carriers for future drug delivery research.