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1,358 results on '"Daly, E."'

1. The Continuous Electron Beam Accelerator Facility at 12 GeV

Author

Adderley, P. A., Ahmed, S., Allison, T., Bachimanchi, R., Baggett, K., BastaniNejad, M., Bevins, B., Bevins, M., Bickley, M., Bodenstein, R. M., Bogacz, S. A., Bruker, M., Burrill, A., Cardman, L., Creel, J., Chao, Y. -C., Cheng, G., Ciovati, G., Chattopadhyay, S., Clark, J., Clemens, W. A., Croke, G., Daly, E., Davis, G. K., Delayen, J., De Silva, S. U., Dickson, R., Diaz, M., Drury, M., Doolittle, L., Douglas, D., Feldl, E., Fischer, J., Freyberger, A., Ganni, V., Geng, R. L., Ginsburg, C., Gomez, J., Grames, J., Gubeli, J., Guo, J., Hannon, F., Hansknecht, J., Harwood, L., Henry, J., Hernandez-Garcia, C., Higgins, S., Higinbotham, D., Hofler, A. S., Hiatt, T., Hogan, J., Hovater, C., Hutton, A., Jones, C., Jordan, K., Joyce, M., Kazimi, R., Keesee, M., Kelley, M. J., Keppel, C., Kimber, A., King, L., Kjeldsen, P., Kneisel, P., Koval, J., Krafft, G. A., Lahti, G., Larrieu, T., Lauze, R., Leemann, C., Legg, R., Li, R., Lin, F., Machie, D., Mammosser, J., Macha, K., Mahoney, K., Marhauser, F., Mastracci, B., Matalevich, J., McCarter, J., McCaughan, M., Merminga, L., Michaud, R., Morozov, V., Mounts, C., Musson, J., Nelson, R., Oren, W., Overton, R. B., Palacios-Serrano, G., Park, H. -K., Phillips, L., Philip, S., Pilat, F., Plawski, T., Poelker, M., Powers, P., Powers, T., Preble, J., Reilly, T., Rimmer, R., Reece, C., Robertson, H., Roblin, Y., Rode, C., Satogata, T., Seidman, D. J., Seryi, A., Shabalina, A., Shin, I., Slominski, R., Slominski, C., Spata, M., Spell, D., Spradlin, J., Stirbet, M., Stutzman, M. L., Suhring, S., Surles-Law, K., Suleiman, R., Tennant, C., Tian, H., Turner, D., Tiefenback, M., Trofimova, O., Valente, A. -M., Wang, H., Wang, Y., White, K., Whitlatch, C., Whitlatch, T., Wiseman, M., Wissman, M. J., Wu, G., Yang, S., Yunn, B., Zhang, S., and Zhang, Y.

Subjects
Physics - Accelerator Physics, Nuclear Experiment
Abstract

This review paper describes the energy-upgraded CEBAF accelerator. This superconducting linac has achieved 12 GeV beam energy by adding 11 new high-performance cryomodules containing eighty-eight superconducting cavities that have operated CW at an average accelerating gradient of 20 MV/m. After reviewing the attributes and performance of the previous 6 GeV CEBAF accelerator, we discuss the upgraded CEBAF accelerator system in detail with particular attention paid to the new beam acceleration systems. In addition to doubling the acceleration in each linac, the upgrade included improving the beam recirculation magnets, adding more helium cooling capacity to allow the newly installed modules to run cold, adding a new experimental hall, and improving numerous other accelerator components. We review several of the techniques deployed to operate and analyze the accelerator performance, and document system operating experience and performance. In the final portion of the document, we present much of the current planning regarding projects to improve accelerator performance and enhance operating margins, and our plans for ensuring CEBAF operates reliably into the future. For the benefit of potential users of CEBAF, the performance and quality measures for beam delivered to each of the experimental halls is summarized in the appendix., Comment: 66 pages, 73 figures, 21 tables

Published
2024
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3. Development of a prototype superconducting radio-frequency cavity for conduction-cooled accelerators

Author

Ciovati, G., Anderson, J., Balachandran, S., Cheng, G., Coriton, B., Daly, E., Dhakal, P., Gurevich, A., Hannon, F., Harding, K., Holland, L., Marhauser, F., McLaughlin, K., Packard, D., Powers, T., Pudasaini, U., Rathke, J., Rimmer, R., Schultheiss, T., Vennekate, H., and Vollmer, D.

Subjects
Physics - Accelerator Physics, Condensed Matter - Superconductivity
Abstract

The higher efficiency of superconducting radio-frequency (SRF) cavities compared to normal-conducting ones enables the development of high-energy continuous-wave linear accelerators (linacs). Recent progress in the development of high-quality Nb$_3$Sn film coatings along with the availability of cryocoolers with high cooling capacity at 4 K makes it feasible to operate SRF cavities cooled by thermal conduction at relevant accelerating gradients for use in accelerators. A possible use of conduction-cooled SRF linacs is for environmental applications, requiring electron beams with energy of $1 - 10$ MeV and 1 MW of power. We have designed a 915 MHz SRF linac for such an application and developed a prototype single-cell cavity to prove the proposed design by operating it with cryocoolers at the accelerating gradient required for 1 MeV energy gain. The cavity has a $\sim 3$ $\mu$m thick Nb$_3$Sn film on the inner surface, deposited on a $\sim4$ mm thick bulk Nb substrate and a bulk $\sim7$ mm thick Cu outer shell with three Cu attachment tabs. The cavity was tested up to a peak surface magnetic field of 53 mT in liquid He at 4.3 K. A horizontal test cryostat was designed and built to test the cavity cooled with three Gifford-McMahon cryocoolers. The rf tests of the conduction-cooled cavity, performed at General Atomics, achieved a peak surface magnetic field of 50 mT and stable operation was possible with up to 18.5 W of rf heat load. The peak frequency shift due to microphonics was 23 Hz. These results represent the highest peak surface magnetic field achieved in a conduction-cooled SRF cavity to date and meet the requirements for a 1 MeV energy gain.

Published
2023
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5. The Large Hadron-Electron Collider at the HL-LHC

Author

Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., and Zurita, P.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment, Nuclear Theory
Abstract

The Large Hadron electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High Luminosity--Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operation. This report represents an update of the Conceptual Design Report (CDR) of the LHeC, published in 2012. It comprises new results on parton structure of the proton and heavier nuclei, QCD dynamics, electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics in extending the accessible kinematic range in lepton-nucleus scattering by several orders of magnitude. Due to enhanced luminosity, large energy and the cleanliness of the hadronic final states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, the report represents a detailed updated design of the energy recovery electron linac (ERL) including new lattice, magnet, superconducting radio frequency technology and further components. Challenges of energy recovery are described and the lower energy, high current, 3-turn ERL facility, PERLE at Orsay, is presented which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution and calibration goals which arise from the Higgs and parton density function physics programmes. The paper also presents novel results on the Future Circular Collider in electron-hadron mode, FCC-eh, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies., Comment: 373 pages, many figures, to be published by J. Phys. G

Published
2020
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6. Brain morphometry in 22q11.2 deletion syndrome: an exploration of differences in cortical thickness, surface area, and their contribution to cortical volume.

Author

Gudbrandsen, M, Daly, E, Murphy, CM, Blackmore, CE, Rogdaki, M, Mann, C, Bletsch, A, Kushan, L, Bearden, CE, Murphy, DGM, Craig, MC, and Ecker, Christine

Subjects
Brain, Cerebral Cortex, Humans, DiGeorge Syndrome, Magnetic Resonance Imaging, Schizophrenia, Psychiatric Status Rating Scales, Surface Properties, Adolescent, Adult, Child, Female, Male, Young Adult, Brain Cortical Thickness
Abstract

22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion in humans, with a heterogenous clinical presentation including medical, behavioural and psychiatric conditions. Previous neuroimaging studies examining the neuroanatomical underpinnings of 22q11.2DS show alterations in cortical volume (CV), cortical thickness (CT) and surface area (SA). The aim of this study was to identify (1) the spatially distributed networks of differences in CT and SA in 22q11.2DS compared to controls, (2) their unique and spatial overlap, as well as (3) their relative contribution to observed differences in CV. Structural MRI scans were obtained from 62 individuals with 22q11.2DS and 57 age-and-gender-matched controls (aged 6-31). Using FreeSurfer, we examined differences in vertex-wise estimates of CV, CT and SA at each vertex, and compared the frequencies of vertices with a unique or overlapping difference for each morphometric feature. Our findings indicate that CT and SA make both common and unique contributions to volumetric differences in 22q11.2DS, and in some areas, their strong opposite effects mask differences in CV. By identifying the neuroanatomic variability in 22q11.2DS, and the separate contributions of CT and SA, we can start exploring the shared and distinct mechanisms that mediate neuropsychiatric symptoms across disorders, e.g. 22q11.2DS-related ASD and/or psychosis/schizophrenia.

Published
2020

8. The Neuroanatomy of Autism Spectrum Disorder Symptomatology in 22q11.2 Deletion Syndrome.

Author

Gudbrandsen, M, Daly, E, Murphy, CM, Wichers, RH, Stoencheva, V, Perry, E, Andrews, D, Blackmore, CE, Rogdaki, M, Kushan, L, Bearden, CE, Murphy, DGM, Craig, MC, and Ecker, C

Subjects
Brain Disorders, Autism, Pediatric, Mental Health, Neurosciences, Clinical Research, Intellectual and Developmental Disabilities (IDD), 2.1 Biological and endogenous factors, Aetiology, Mental health, Adolescent, Adult, Autism Spectrum Disorder, Brain, Case-Control Studies, Child, DiGeorge Syndrome, Entorhinal Cortex, Female, Gyrus Cinguli, Humans, Male, Organ Size, Parietal Lobe, Prefrontal Cortex, Temporal Lobe, Young Adult, 22q11.2 Deletion Syndrome, autism spectrum disorder, brain anatomy, neurodevelopment, surface based morphometry, Psychology, Cognitive Sciences, Experimental Psychology
Abstract

22q11.2 Deletion Syndrome (22q11.2DS) is a genetic condition associated with a high prevalence of neuropsychiatric conditions that include autism spectrum disorder (ASD). While evidence suggests that clinical phenotypes represent distinct neurodevelopmental outcomes, it remains unknown whether this translates to the level of neurobiology. To fractionate the 22q11.2DS phenotype on the level of neuroanatomy, we examined differences in vertex-wise estimates of cortical volume, surface area, and cortical thickness between 1) individuals with 22q11.2DS (n = 62) and neurotypical controls (n = 57) and 2) 22q11.2DS individuals with ASD symptomatology (n = 30) and those without (n = 25). We firstly observed significant differences in surface anatomy between 22q11.2DS individuals and controls for all 3 neuroanatomical features, predominantly in parietotemporal regions, cingulate and dorsolateral prefrontal cortices. We also established that 22q11.2DS individuals with ASD symptomatology were neuroanatomically distinct from 22q11.2DS individuals without ASD symptoms, particularly in brain regions that have previously been linked to ASD (e.g., dorsolateral prefrontal cortices and the entorhinal cortex). Our findings indicate that different clinical 22q11.2DS phenotypes, including those with ASD symptomatology, may represent different neurobiological subgroups. The spatially distributed patterns of neuroanatomical differences associated with ASD symptomatology in 22q11.2DS may thus provide useful information for patient stratification and the prediction of clinical outcomes.

Published
2019

10. PERLE: Powerful Energy Recovery Linac for Experiments - Conceptual Design Report

Author

Angal-Kalinin, D., Arduini, G., Auchmann, B., Bernauer, J., Bogacz, A., Bordry, F., Bousson, S., Bracco, C., Brüning, O., Calaga, R., Cassou, K., Chetvertkova, V., Cormier, E., Daly, E., Douglas, D., Dupraz, K., Goddard, B., Henry, J., Hutton, A., Jensen, E., Kaabi, W., Klein, M., Kostka, P., Marhauser, F., Martens, A., Milanese, A., Militsyn, B., Peinaud, Y., Pellegrini, D., Pietralla, N., Pupkov, Y. A., Rimmer, R. A., Schirm, K., Schulte, D., Smith, S., Stocchi, A., Valloni, A., Welsch, C., Willering, G., Wollmann, D., Zimmermann, F., and Zomer, F.

Subjects
Physics - Accelerator Physics
Abstract

A conceptual design is presented of a novel ERL facility for the development and application of the energy recovery technique to linear electron accelerators in the multi-turn, large current and large energy regime. The main characteristics of the powerful energy recovery linac experiment facility (PERLE) are derived from the design of the Large Hadron electron Collider, an electron beam upgrade under study for the LHC, for which it would be the key demonstrator. PERLE is thus projected as a facility to investigate efficient, high current (> 10 mA) ERL operation with three re-circulation passages through newly designed SCRF cavities, at 801.58 MHz frequency, and following deceleration over another three re-circulations. In its fully equipped configuration, PERLE provides an electron beam of approximately 1 GeV energy. A physics programme possibly associated with PERLE is sketched, consisting of high precision elastic electron-proton scattering experiments, as well as photo-nuclear reactions of unprecedented intensities with up to 30 MeV photon beam energy as may be obtained using Fabry-Perot cavities. The facility has further applications as a general technology test bed that can investigate and validate novel superconducting magnets (beam induced quench tests) and superconducting RF structures (structure tests with high current beams, beam loading and transients). Besides a chapter on operation aspects, the report contains detailed considerations on the choices for the SCRF structure, optics and lattice design, solutions for arc magnets, source and injector and on further essential components. A suitable configuration derived from the here presented design concept may next be moved forward to a technical design and possibly be built by an international collaboration which is being established., Comment: 112 pages, 63 figures

Published
2017
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14. Transport of LCLS-II 1.3 Ghz cryomodule to SLAC

Author

McGee, M. W., Arkan, T., Peterson, T., Tang, Z., Boo, S., Carrasco, M., Daly, E., and Huque, N.

Subjects
Physics - Accelerator Physics
Abstract

In a partnership with SLAC National Accelerator Laboratory (SLAC) and Jefferson Lab, Fermilab will assemble and test 17 of the 35 total 1.3 GHz cryomodules for the Linac Coherent Light Source II (LCLS-II) Project. These include a prototype built and delivered by each Lab. Another two 3.9 GHz cryomodules will be built, tested and transported by Fermilab to SLAC. Each assembly will be transported over-the-road from Fermilab or Jefferson Lab using specific routes to SLAC. The transport system consists of a base frame, isolation fixture and upper protective truss. The strongback cryomodule lifting fixture is described along with other supporting equipment used for both over-the-road transport and local (on-site) transport at Fermilab. Initially, analysis of fragile components and stability studies will be performed in order to assess the risk associated with over-the-road transport of a fully assembled cryomodule., Comment: 3 pp

Published
2016

15. Laser-plasma-based Space Radiation Reproduction in the Laboratory.

Author

Hidding, B, Karger, O, Königstein, T, Pretzler, G, Manahan, GG, McKenna, P, Gray, R, Wilson, R, Wiggins, SM, Welsh, GH, Beaton, A, Delinikolas, P, Jaroszynski, DA, Rosenzweig, JB, Karmakar, A, Ferlet-Cavrois, V, Costantino, A, Muschitiello, M, and Daly, E

Subjects
Biochemistry and Cell Biology, Other Physical Sciences
Abstract

Space radiation is a great danger to electronics and astronauts onboard space vessels. The spectral flux of space electrons, protons and ions for example in the radiation belts is inherently broadband, but this is a feature hard to mimic with conventional radiation sources. Using laser-plasma-accelerators, we reproduced relativistic, broadband radiation belt flux in the laboratory, and used this man-made space radiation to test the radiation hardness of space electronics. Such close mimicking of space radiation in the lab builds on the inherent ability of laser-plasma-accelerators to directly produce broadband Maxwellian-type particle flux, akin to conditions in space. In combination with the established sources, utilisation of the growing number of ever more potent laser-plasma-accelerator facilities worldwide as complementary space radiation sources can help alleviate the shortage of available beamtime and may allow for development of advanced test procedures, paving the way towards higher reliability of space missions.

Published
2017

16. Australian non-perennial rivers: Global lessons and research opportunities

Author

Shanafield, M, Blanchette, M, Daly, E, Wells, N, Burrows, RM, Korbel, K, Rau, GC, Bourke, S, Wakelin-King, G, Holland, A, Ralph, T, Mcgrath, G, Robson, B, Fowler, K, Andersen, MS, Yu, S, Jones, CS, Waltham, N, Banks, EW, Flatley, A, Leigh, C, Maxwell, S, Siebers, A, Bond, N, Beesley, L, Hose, G, Iles, J, Cartwright, I, Reid, M, Tayer, TDC, Duvert, C, Shanafield, M, Blanchette, M, Daly, E, Wells, N, Burrows, RM, Korbel, K, Rau, GC, Bourke, S, Wakelin-King, G, Holland, A, Ralph, T, Mcgrath, G, Robson, B, Fowler, K, Andersen, MS, Yu, S, Jones, CS, Waltham, N, Banks, EW, Flatley, A, Leigh, C, Maxwell, S, Siebers, A, Bond, N, Beesley, L, Hose, G, Iles, J, Cartwright, I, Reid, M, Tayer, TDC, and Duvert, C

Published
2024

17. The Large Hadron–Electron Collider at the HL-LHC

Author

Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, Zurita, P, Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, and Zurita, P

Abstract

The Large Hadron–Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron–proton and proton–proton operations. This report represents an update to the LHeC’s conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton–nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron–hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.

Published
2024

18. PERLE. Powerful energy recovery linac for experiments. Conceptual design report

Author

Angal-Kalinin, D., Arduini, G., Auchmann, B., Bernauer, J., Bogacz, A., Bordry, F., Bousson, S., Bracco, C., Brüning, O., Calaga, R., Cassou, K., Chetvertkova, V., Cormier, E., Daly, E., Douglas, D., Dupraz, K., Goddard, B., Henry, J., Hutton, A., Jensen, E., Kaabi, W., Klein, M., Kostka, P., Lasheras, N., Levichev, E., Marhauser, F., Martens, A., Milanese, A., Militsyn, B., Peinaud, Y., Pellegrini, D., Pietralla, N., Pupkov, Y., Rimmer, R., Schirm, K., Schulte, D., Smith, S., Stocchi, A., Valloni, A., Welsch, C., Willering, G., Wollmann, D., Zimmermann, F., Zomer, F., Angal-Kalinin, D., Arduini, G., Auchmann, B., Bernauer, J., Bogacz, A., Bordry, F., Bousson, S., Bracco, C., Brüning, O., Calaga, R., Cassou, K., Chetvertkova, V., Cormier, E., Daly, E., Douglas, D., Dupraz, K., Goddard, B., Henry, J., Hutton, A., Jensen, E., Kaabi, W., Klein, M., Kostka, P., Lasheras, N., Levichev, E., Marhauser, F., Martens, A., Milanese, A., Militsyn, B., Peinaud, Y., Pellegrini, D., Pietralla, N., Pupkov, Y., Rimmer, R., Schirm, K., Schulte, D., Smith, S., Stocchi, A., Valloni, A., Welsch, C., Willering, G., Wollmann, D., Zimmermann, F., and Zomer, F.

Abstract

A conceptual design is presented of a novel energy-recovering linac (ERL) facility for the development and application of the energy recovery technique to linear electron accelerators in the multi-turn, large current and large energy regime. The main characteristics of the powerful energy recovery linac experiment facility (PERLE) are derived from the design of the Large Hadron electron Collider, an electron beam upgrade under study for the LHC, for which it would be the key demonstrator. PERLE is thus projected as a facility to investigate efficient, high current (HC) (>10 mA) ERL operation with three re-circulation passages through newly designed SCRF cavities, at 801.58 MHz frequency, and following deceleration over another three re-circulations. In its fully equipped configuration, PERLE provides an electron beam of approximately 1 GeV energy. A physics programme possibly associated with PERLE is sketched, consisting of high precision elastic electron–proton scattering experiments, as well as photo-nuclear reactions of unprecedented intensities with up to 30 MeV photon beam energy as may be obtained using Fabry–Perot cavities. The facility has further applications as a general technology test bed that can investigate and validate novel superconducting magnets (beam induced quench tests) and superconducting RF structures (structure tests with HC beams, beam loading and transients). Besides a chapter on operation aspects, the report contains detailed considerations on the choices for the SCRF structure, optics and lattice design, solutions for arc magnets, source and injector and on further essential components. A suitable configuration derived from the here presented design concept may next be moved forward to a technical design and possibly be built by an international collaboration which is being established.

Published
2024

19. MEIC Design Summary

Author

Abeyratne, S., Barber, D., Bogacz, A., Brindza, P., Cai, Y., Camsonne, A., Castilla, A., Chevtsov, P., Daly, E., Derbenev, Y. S., Douglas, D., Dudnikov, V., Ent, R., Erdelyi, B., Filatov, Y., Gaskell, D., Grames, J., Guo, J., Harwood, L., Hutton, A., Hyde, C., Jordan, K., Kimber, A., Krafft, G. A., Kondratenko, A., Kondratenko, M., Li, R., Lin, F., Mann, T., McIntyre, P., Michalski, T., Morozov, V. S., Nadel-Turonski, P., Nosochkov, Y. M., Ostroumov, P. N., Park, K., Pilat, F., Poelker, M., Pogue, N. J., Rimmer, R., Roblin, Y., Satogata, T., Sattarov, A., Spata, M., Suleiman, R., Sullivan, M., Sy, A., Tennant, C., Wang, H., Wang, M-H, Wang, S., Wienands, U., Zhang, H., Zhang, Y., and Zhao, Z.

Subjects
Physics - Accelerator Physics
Abstract

This document summarizes the design of Jefferson Lab's electron-ion collider, MEIC, as of January 20, 2015, and describes the facility whose cost was estimated for the United States Department of Energy Nuclear Sciences Advisory Committee EIC cost review of January 26-28, 2015. In particular, each of the main technical systems within the collider is presented to the level of the best current information.

Published
2015

22. Relationship Between Cortical Gyrification, White Matter Connectivity, and Autism Spectrum Disorder.

Author

Ecker, C, Andrews, Derek, DellAcqua, F, Daly, E, Murphy, C, Catani, M, Thiebaut de Schotten, M, Baron-Cohen, S, Lai, M, Lombardo, M, Bullmore, E, Suckling, J, Williams, S, Jones, D, Chiocchetti, A, and Murphy, D

Subjects
Autism spectrum disorder, brain anatomy, brain connectivity, brain development, multimodal neuroimaging, Adolescent, Adult, Autism Spectrum Disorder, Cerebral Cortex, Diffusion Tensor Imaging, Gray Matter, Humans, Imaging, Three-Dimensional, Intelligence, Magnetic Resonance Imaging, Male, Neural Pathways, Organ Size, Pattern Recognition, Automated, White Matter, Young Adult
Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, which is accompanied by differences in gray matter neuroanatomy and white matter connectivity. However, it is unknown whether these differences are linked or reflect independent aetiologies. Using a multimodal neuroimaging approach, we therefore examined 51 male adults with ASD and 48 neurotypical controls to investigate the relationship between gray matter local gyrification (lGI) and white matter diffusivity in associated fiber tracts. First, ASD individuals had a significant increase in gyrification around the left pre- and post-central gyrus. Second, white matter fiber tracts originating and/or terminating in the cluster of increased lGI had a significant increase in axial diffusivity. This increase in diffusivity was predominantly observed in tracts in close proximity to the cortical sheet. Last, we demonstrate that the increase in lGI was significantly correlated with increased diffusivity of short tracts. This relationship was not significantly modulated by a main effect of group (i.e., ASD), which was more closely associated with gray matter gyrification than white matter diffusivity. Our findings suggest that differences in gray matter neuroanatomy and white matter connectivity are closely linked, and may reflect common rather than distinct aetiological pathways.

Published
2016

23. The Highly Miniaturised Radiation Monitor

Author

Mitchell, E. F., Araújo, H. M., Daly, E., Guerrini, N., Gunes-Lasnet, S., Griffin, D., Marshall, A., Menicucci, A., Morse, T., Poyntz-Wright, O., Turchetta, R., and Woodward, S.

Subjects
Physics - Instrumentation and Detectors
Abstract

We present the design and preliminary calibration results of a novel highly miniaturised particle radiation monitor (HMRM) for spacecraft use. The HMRM device comprises a telescopic configuration of active pixel sensors enclosed in a titanium shield, with an estimated total mass of 52 g and volume of 15 cm$^3$. The monitor is intended to provide real-time dosimetry and identification of energetic charged particles in fluxes of up to 10$^8$ cm$^{-2}$ s$^{-1}$ (omnidirectional). Achieving this capability with such a small instrument could open new prospects for radiation detection in space., Comment: 17 pages, 15 figures

Published
2014
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26. Stochastic Modeling of Soil Salinity

Author

Suweis, S., Rinaldo, A., Van der Zee, S. E. A. T. M., Daly, E., Maritan, A., and Porporato, A.

Subjects
Physics - Geophysics
Abstract

A minimalist stochastic model of primary soil salinity is proposed, in which the rate of soil salinization is determined by the balance between dry and wet salt deposition and the intermittent leaching events caused by rainfall events. The long term probability density functions of salt mass and concentration are found by reducing the coupled soil moisture and salt mass balance equation to a single stochastic differential equation driven by multiplicative Poisson noise. The novel analytical solutions provide insight on the interplay of the main soil, plant and climate parameters responsible for long-term soil salinization. In particular, they show the existence of two distinct regimes, one where the mean salt mass remains nearly constant (or decreases) with increasing rainfall frequency, and another where mean salt content increases markedly with increasing rainfall frequency. As a result, relatively small reductions of rainfall in drier climates may entail dramatic shifts in long-term soil salinization trends, with significant consequences e.g. for climate change impacts on rain-fed agriculture., Comment: 17 pages, 3 figures

Published
2012
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31. The dynamically neurodiverse human brain: Measuring excitatory-inhibitory dynamics and identifying homeostatic differences in autistic and non-autistic people

Author

Ellis, C. L., primary, Ahmad, J., additional, Zoumpoulaki, A., additional, Dimitrov, M., additional, Velthuis, H. E., additional, Pereira, A. C., additional, Wong, N. M. L., additional, Ponteduro, M. F., additional, Kowalewski, L., additional, Leonard, A., additional, Garces, P., additional, Huang, Q., additional, Daly, E., additional, Murphy, D., additional, and McAlonan, G., additional

Published
2023
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32. Segmented SRF Cryomodules

Author

Daly, E., Nicol, Thomas H., Preble, J., Van Sciver, Steven W., Series editor, Jeong, Sangkwon, Series editor, and Weisend II, J.G., editor

Published
2016
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35. Development of a prototype superconducting radio-frequency cavity for conduction-cooled accelerators

Author

Ciovati, G., primary, Anderson, J., additional, Balachandran, S., additional, Cheng, G., additional, Coriton, B., additional, Daly, E., additional, Dhakal, P., additional, Gurevich, A., additional, Hannon, F., additional, Harding, K., additional, Holland, L., additional, Marhauser, F., additional, McLaughlin, K., additional, Packard, D., additional, Powers, T., additional, Pudasaini, U., additional, Rathke, J., additional, Rimmer, R., additional, Schultheiss, T., additional, Vennekate, H., additional, and Vollmer, D., additional

Published
2023
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36. AlphaZero beats Stockfish 28 to 0. Artificial Intelligence, chess game and strategic choices [AlphaZero batte Stockfish 28 a 0 Intelligenza Artificiale, gioco degli scacchi e scelte strategiche]

Author

Daly, E and Daly, E

Abstract

The essay discusses the subject of Artificial Intelligence (AI) algorithms and the legal principles governing this matter. The functioning of the algorithms Turochamp, Stockfish, AlphaZero, used in the game of chess, is described in detail. Based on these examples, the differences between deterministic, non-strictly deterministic algorithms and self-training AI algorithms are analysed, up to the topic of opacity and black box, typical of deep-learning systems. Finally, the issue of the transparency and explicability required by jurisprudence for the use of AI algorithms in the public sphere and the compatibility of these legal principles with the functioning of these new technologies are addressed.

Published
2023

37. Il trattamento medico-psichiatrico alla luce della Costituzione, dei principi del diritto e della bioetica

Author

Daly, E, BORSELLINO, PATRIZIA, DALY, ENRICO, Daly, E, BORSELLINO, PATRIZIA, and DALY, ENRICO

Abstract

La tesi di dottorato è composta di tre parti. Nella prima parte della tesi viene analizzato il contesto storico-culturale nel quale è maturata la legge Basaglia (antipsichiatria, contestazione sessantottina, biopolitica e filosofie del controllo sociale). È inoltre presente una dettagliata analisi di carattere strettamente giuridico della problematica dei trattamenti sanitari obbligatori: a livello costituzionale si affronta il tema della libertà personale (art. 13 Cost.), del diritto alla salute (art. 32 Cos.) e del rapporto che, nel tempo, la dottrina ha ritenuto di poter instaurare tra i due articoli summenzionati, mentre, a livello di normazione primaria, si analizzano le leggi che, nel ‘900, hanno governato la materia del trattamento medico-psichiatrico (dalla legge manicomiale del 1904 fino alla legge Basaglia del 1978). Sono altresì raccolte e analizzate le varie opinioni dottrinali e le pronunce giurisprudenziali più rilevanti sulla normativa in questione. Si affronta, inoltre, anche il tema più ampio del “consenso informato” ai trattamenti sanitari, con riferimenti alle più recenti teorie bioetiche. Nella seconda parte della tesi, invece, la legge Basaglia viene esaminata dal punto di vista applicativo. Sulla base dell’analisi quantitativa dei dati ufficiali comunicati dal Ministero della Salute, si contesta la tesi dell’avvenuta costituzionalizzazione della pratica psichiatrica nel nostro Paese e si rileva come, per converso, si possa concludere nel senso di una tendenza alla progressiva “re-istituzionalizzazione” del paziente psichiatrico nelle cd. Strutture Residenziali (SR), da considerarsi, in alcuni casi, ispirate a logiche meramente custodialistiche di carattere neo-manicomiale. L’esame dei dati quantitativi sulla durata pluriennale dei ricoveri in SR è accompagnato dall’analisi dei “nuovi” istituti giuridici creati, in via interpretativa, dall’intervento massiccio delle Regioni in ambito sanitario (TSOE, TSO cd. “puntiforme”), intervento co, The doctoral thesis consists of three parts. The first part of the thesis analyses the historical and cultural context in which the Basaglia law came about (anti-psychiatry, 1968 protest, biopolitics and philosophies of social control). There is also a detailed analysis of a strictly legal nature of the issue of compulsory medical treatment: at a constitutional level, the theme of personal freedom (art. 13 of the Constitution), the right to health (art. 32 of the Constitution) and the relationship that, over time, doctrine has deemed it’s possible to establish between the two aforementioned articles are addressed, while, at the level of primary legislation, the laws that, in the 20th century, have governed the subject of medical-psychiatric treatment are analysed (from the 1904 asylum law to the 1978 Basaglia law). The various doctrinal opinions and the most relevant jurisprudential pronouncements on the legislation in question are also collected and analysed. The broader theme of “informed consent'” to health treatments is also addressed, with references to the most recent bioethical theories. In the second part of the thesis, on the other hand, the Basaglia law is examined from the point of view of its application. On the basis of the quantitative analysis of the official data communicated by the Ministry of Health, the thesis of the constitutionalisation of psychiatric practice in our country is contested and, conversely, it is noted how one can conclude in the sense of a tendency towards the progressive “re-institutionalisation” of the psychiatric patient in the so-called Residential Structures, in which the psychiatric patient is being treated in the psychiatric system. Residential Structures, to be considered, in some cases, inspired by merely custodialist logics of a neo-manicomialist nature. The examination of the quantitative data on the multi-year duration of admissions to residential structures is accompanied by an analysis of the “new” legal institutions

Published
2023

38. AlphaZero batte Stockfish 28 a 0. Intelligenza Artificiale, gioco degli scacchi e scelte strategiche [AlphaZero beats Stockfish 28 to 0. Artificial Intelligence, chess game and strategic choices]

Author

Daly, Enrico, Daly E. (ORCID:0000-0002-2891-7107), Daly, Enrico, and Daly E. (ORCID:0000-0002-2891-7107)

Abstract

The essay discusses the subject of Artificial Intelligence (AI) algorithms and the legal principles governing this matter. The functioning of the algorithms Turochamp, Stockfish, AlphaZero, used in the game of chess, is described in detail. Based on these examples, the differences between deterministic, non-strictly deterministic algorithms and self-training AI algorithms are analysed, up to the topic of opacity and black box, typical of deep-learning systems. Finally, the issue of the transparency and explicability required by jurisprudence for the use of AI algorithms in the public sphere and the compatibility of these legal principles with the functioning of these new technologies are addressed.

Published
2023

45. The Spallation Neutron Source accelerator system design

Author

Henderson, S., Abraham, W., Aleksandrov, A., Allen, C., Alonso, J., Anderson, D., Arenius, D., Arthur, T., Assadi, S., Ayers, J., Bach, P., Badea, V., Battle, R., Beebe-Wang, J., Bergmann, B., Bernardin, J., Bhatia, T., Billen, J., Birke, T., Bjorklund, E., Blaskiewicz, M., Blind, B., Blokland, W., Bookwalter, V., Borovina, D., Bowling, S., Bradley, J., Brantley, C., Brennan, J., Brodowski, J., Brown, S., Brown, R., Bruce, D., Bultman, N., Cameron, P., Campisi, I., Casagrande, F., Catalan-Lasheras, N., Champion, M., Chen, Z., Cheng, D., Cho, Y., Christensen, K., Chu, C., Cleaves, J., Connolly, R., Cote, T., Cousineau, S., Crandall, K., Creel, J., Crofford, M., Cull, P., Cutler, R., Dabney, R., Dalesio, L., Daly, E., Damm, R., Danilov, V., Davino, D., Davis, K., Dawson, C., Day, L., Deibele, C., Delayen, J., DeLong, J., Demello, A., DeVan, W., Digennaro, R., Dixon, K., Dodson, G., Doleans, M., Doolittle, L., Doss, J., Drury, M., Elliot, T., Ellis, S., Error, J., Fazekas, J., Fedotov, A., Feng, P., Fischer, J., Fox, W., Fuja, R., Funk, W., Galambos, J., Ganni, V., Garnett, R., Geng, X., Gentzlinger, R., Giannella, M., Gibson, P., Gillis, R., Gioia, J., Gordon, J., Gough, R., Greer, J., Gregory, W., Gribble, R., Grice, W., Gurd, D., Gurd, P., Guthrie, A., Hahn, H., Hardek, T., Hardekopf, R., Harrison, J., Hatfield, D., He, P., Hechler, M., Heistermann, F., Helus, S., Hiatt, T., Hicks, S., Hill, J., Hoff, L., Hoff, M., Hogan, J., Holding, M., Holik, P., Holmes, J., Holtkamp, N., Hovater, C., Howell, M., Hseuh, H., Huhn, A., Hunter, T., Ilg, T., Jackson, J., Jain, A., Jason, A., Jeon, D., Johnson, G., Jones, A., Joseph, S., Justice, A., Kang, Y., Kasemir, K., Keller, R., Kersevan, R., Kerstiens, D., Kesselman, M., Kim, S., Kneisel, P., Kravchuk, L., Kuneli, T., Kurennoy, S., Kustom, R., Kwon, S., Ladd, P., Lambiase, R., Lee, Y.Y., Leitner, M., Leung, K.-N., Lewis, S., Liaw, C., Lionberger, C., Lo, C.C., Long, C., Ludewig, H., Ludvig, J., Luft, P., Lynch, M., Ma, H., MacGill, R., Macha, K., Madre, B., Mahler, G., Mahoney, K., Maines, J., Mammosser, J., Mann, T., Marneris, I., Marroquin, P., Martineau, R., Matsumoto, K., McCarthy, M., McChesney, C., McGahern, W., McGehee, P., Meng, W., Merz, B., Meyer, R., Jr., Meyer, R., Sr., Miller, B., Mitchell, R., Mize, J., Monroy, M., Munro, J., Murdoch, G., Musson, J., Nath, S., Nelson, R., O׳Hara, J., Olsen, D., Oren, W., Oshatz, D., Owens, T., Pai, C., Papaphilippou, I., Patterson, N., Patterson, J., Pearson, C., Pelaia, T., Pieck, M., Piller, C., Plawski, T., Plum, M., Pogge, J., Power, J., Powers, T., Preble, J., Prokop, M., Pruyn, J., Purcell, D., Rank, J., Raparia, D., Ratti, A., Reass, W., Reece, K., Rees, D., Regan, A., Regis, M., Reijonen, J., Rej, D., Richards, D., Richied, D., Rode, C., Rodriguez, W., Rodriguez, M., Rohlev, A., Rose, C., Roseberry, T., Jr., Rowton, L., Roybal, W., Rust, K., Salazer, G., Sandberg, J., Saunders, J., Schenkel, T., Schneider, W., Schrage, D., Schubert, J., Severino, F., Shafer, R., Shea, T., Shishlo, A., Shoaee, H., Sibley, C., Sims, J., Smee, S., Smith, J., Smith, K., Spitz, R., Staples, J., Stein, P., Stettler, M., Stirbet, M., Stockli, M., Stone, W., Stout, D., Stovall, J., Strelo, W., Strong, H., Sundelin, R., Syversrud, D., Szajbler, M., Takeda, H., Tallerico, P., Tang, J., Tanke, E., Tepikian, S., Thomae, R., Thompson, D., Thomson, D., Thuot, M., Treml, C., Tsoupas, N., Tuozzolo, J., Tuzel, W., Vassioutchenko, A., Virostek, S., Wallig, J., Wanderer, P., Wang, Y., Wang, J.G., Wangler, T., Warren, D., Wei, J., Weiss, D., Welton, R., Weng, J., Weng, W-T., Wezensky, M., White, M., Whitlatch, T., Williams, D., Williams, E., Wilson, K., Wiseman, M., Wood, R., Wright, P., Wu, A., Ybarrolaza, N., Young, K., Young, L., Yourd, R., Zachoszcz, A., Zaltsman, A., Zhang, S., Zhang, W., Zhang, Y., and Zhukov, A.

Published
2014
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47. La distinzione fra trattamento sanitario 'obbligatorio' e trattamento sanitario 'coattivo' nella recente giurisprudenza della Corte costituzionale. Luci e ombre

Author

Daly, E and Daly, E

Subjects
IUS/09 - ISTITUZIONI DI DIRITTO PUBBLICO, IUS/20 - FILOSOFIA DEL DIRITTO, compulsory medical treatment, mandatory medical treatment, REMS, psychiatry, Law no. 180/1978
Abstract

Con la sentenza 22/2022 la Corte costituzionale ha recepito nella propria giurisprudenza la summa divisio, operata dalla dottrina, fra trattamenti sanitari obbligatori e trattamenti sanitari coattivi, delimitando al contempo l’ambito di validità degli artt. 13 e 32 Cost. La Corte costituzionale, tuttavia, nell’analizzare la misura di sicurezza dell’assegnazione a una REMS (“Residenza per l’Esecuzione delle Misure di Sicurezza”), ha teorizzato l’esistenza, nell’ordinamento giuridico, di un trattamento sanitario coattivo differente da quello previsto dalla L. n. 180/1978. Il presente contributo affronta in modo critico l’esame di tale assunto, ribadendo la necessità di un eguale trattamento per tutti i soggetti sottoposti a misure restrittive della libertà personale, sia nel caso in cui essi scontino una pena in carcere oppure nel momento in cui, giudicati non imputabili, siano assegnati a una REMS. In the judgment no. 22/2022 the Constitutional Court incorporated into its case law the summa divisio, made by the legal literature, between mandatory and compulsory medical treatment, delimiting at the same time the scope of articles 13 and 32 of the Constitution. The Constitutional Court, however, in analysing the security measure of assignment to a REMS (an acronym for “Residenza per l’Esecuzione delle Misure di Sicurezza”, i.e. Residence for the Execution of Security Measures), theorised the existence, in the legal system, of a compulsory health treatment different from that provided for by Law no. 180/1978. The present contribution critically examines this assumption, reiterating the need for equal treatment for all persons subjected to measures restricting personal freedom, both when they serve a prison sentence and when, judged not imputable, they are assigned to a REMS.

Published
2022

48. A simple rule governs the evolution and development of hominin tooth size

Author

Evans, Alistair R., Daly, E. Susanne, Catlett, Kierstin K., Paul, Kathleen S., King, Stephen J., Skinner, Matthew M., Nesse, Hans P., Hublin, Jean-Jacques, Townsend, Grant C., Schwartz, Gary T., and Jernvall, Jukka

Subjects
Evolutionary biology -- Research, Developmental biology -- Research, Fossil hominids -- Physiological aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The variation in molar tooth size in humans and our closest relatives (hominins) has strongly influenced our view of human evolution. The reduction in overall size and disproportionate decrease in third molar size have been noted for over a century, and have been attributed to reduced selection for large dentitions owing to changes in diet or the acquisition of cooking (1,2). The systematic pattern of size variation along the tooth row has been described as a 'morphogenetic gradient' in mammal, and more specifically hominin, teeth since Butler (3) and Dahlberg (4). However, the underlying controls of tooth size have not been well understood, with hypotheses ranging from morphogenetic fields (3) to the clone theory (5). In this study we address the following question: are there rules that govern how hominin tooth size evolves? Here we propose that the inhibitory cascade, an activator-inhibitor mechanism that affects relative tooth size in mammals (6), produces the default pattern of tooth sizes for all lower primary postcanine teeth (deciduous premolars and permanent molars) in hominins. This configuration is also equivalent to a morphogenetic gradient, finally pointing to a mechanism that can generate this gradient. The pattern of tooth size remains constant with absolute size in australopiths (including Ardipithecus, Australopithecus and Paranthropus). However, in species of Homo, including modern humans, there is a tight link between tooth proportions and absolute size such that a single developmental parameter can explain both the relative and absolute sizes of primary postcanine teeth. On the basis of the relationship of inhibitory cascade patterning with size, we can use the size at one tooth position to predict the sizes of the remaining four primary postcanine teeth in the row for hominins. Our study provides a development-based expectation to examine the evolution of the unique proportions of human teeth., Nearly 80 years ago, Butler (3,7) described the morphogenetic gradient in mammalian postcanine teeth. From anterior to posterior, the deciduous premolars and molars increase in size, and in some species [...]

Published
2016

49. The impact of alternating drainage and inundation cycles on geochemistry and microbiology of intact peat cores

Author

Healy, Mark G., Siggins, Alma, Potito, Aaron P., Molloy, Karen, O'Leary, D., Daly, E., Callery, O., European Commission, and Environmental Protection Agency

Subjects
restoration, Environmental Engineering, Nitrates, rewetting, Nitrogen, Soil-water characteristic curve, Water, Phosphorus, Pollution, Soil, Microbial community, Environmental Chemistry, Waste Management and Disposal, peatlands
Abstract

The rewetting of degraded peatlands has been adopted as a method to address climate change. Concerns have been raised about the effects of peat inundation and drying cycles, in more extreme climate events, on the potential release of nitrogen (N) species, in particular ammonium (NH4-N), once rewetted, as well as the physico-chemical and biological properties of the peat. This study used intact peat cores to measure the impact of two different cycles of peat inundation and drying (1 month and 2 month) over a total study duration of 56 weeks on the (1) NH4-N, nitrate-N (NO3-N) and dissolved reactive phosphorus (DRP) in the soil pore water; (2) microbial community structure; (3) physico-chemical properties of the peat; and (4) the structure of the peat, and therefore its ability to mitigate flood risks and storm surges. The study found that rewetted cores released NO3-N in the pore water up to a concentration of 6.25 mg L-1, but had no appreciable impact on NH4-N, which remained below 1.7 mg L-1 over the study duration. DRP moved quickly though the upper layers of the cores, but physico-chemical analysis suggested it was adsorbed to more iron-rich soil, which was present at depths below 0.4 m in the cores. Time intervals between inundation produced no significant difference on the forms of inorganic N released, nor did it compact the soil or change the microbial community structure. The depth of the water table, however, had a significant impact on inorganic N release, particularly NO3-N, which indicates that this N species, and not NH4-N, may be problematic in rewetted peatlands. The authors acknowledge the assistance of Stephen Monteverde and Dr Siubhán Comer. The authors would like to thank the European Commission and the Irish Environmental Protection Agency (EPA) (Project reference number 2019-W-MS-42) for funding the collaborative international consortium (WATERPEAT) financed under the Water JPI 2018 Joint Call of the WaterWorks2017 ERA-NET Cofund. This project is funded under the EPA Research Programme 2014-2020. The EPA Research Programme is a Government of Ireland initiative funded by the Department of Communications, Climate Action and Environment. It is administered by the Environmental Protection Agency, which has the statutory function of co-ordinating and promoting environmental research. peer-reviewed 2024-11-02

Published
2022

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