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643 results on '"Dallinga-Thie, Geesje M"'

1. Elevated Lipoprotein(a) in Perinatally HIV-Infected Children Compared With Healthy Ethnicity-Matched Controls

Author

Van den Hof, Malon, Haneveld, Mirthe J Klein, Blokhuis, Charlotte, Scherpbier, Henriette J, Jansen, Hans PG, Kootstra, Neeltje A, Dallinga-Thie, Geesje M, Van Deventer, Sander JH, Tsimikas, Sotirios, Pajkrt, Dasja, Van den Hof, M, Blokhuis, C, Cohen, S, Pajkrt, D, Scherpbier, HJ, Kuijpers, TW, van der Plas, A, Weijsenfeld, A, Stege, JS ter, Kootstra, NA, Caan, MWA, Mutsaerts, HJMM, Majoie, CBLM, Demirkaya, N, Verbraak, FD, Schmand, B, Geurtsen, G, Mathot, RAA, Wit, FWNM, Reiss, P, Teunissen, CE, Kuhle, J, and Meijer, JCM

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Pediatric, Clinical Research, Atherosclerosis, Prevention, Infectious Diseases, Heart Disease, Good Health and Well Being, cardiovascular disease risk, lipids, lipoprotein(a), MRI, perinatal HIV infection, NOVICE study group, Clinical sciences, Medical microbiology
Abstract

BackgroundHIV-associated cardiovascular disease (CVD) risk in combination antiretroviral therapy (cART)-treated perinatally HIV-infected patients (PHIV+) remains unknown due to the young age of this population. Lipoprotein(a) (Lp(a)) has been established as an independent causal risk factor for CVD in the general population but has not been well established in the population of PHIV+.MethodsWe cross-sectionally compared lipid profiles, including nonfasting Lp(a), together with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides between 35 cART-treated PHIV+ children aged 8-18 years and 37 controls who were matched for age, sex, ethnicity, and socioeconomic status. We explored associations between Lp(a) and disease- and treatment-related factors (inflammation, monocyte activation, and vascular), biomarkers, and neuroimaging outcomes using linear regression models.ResultsPHIV+ children had significantly higher levels of Lp(a) compared with controls (median, 43.6 [21.6-82.4] vs 21.8 [16.8-46.6] mg/dL; P = .033). Other lipid levels were comparable between groups. Additional assessment of apolipoprotein B, apolipoprotein CIII, apolipoprotein E, and APOE genotype revealed no significant differences. Higher Lp(a) levels were associated with higher plasma apoB levels and with lower monocyte chemoattractant protein-1 and TG levels in PHIV+ children. Lp(a) was not associated with HIV- or cART-related variables or with neuroimaging outcomes.ConclusionscART-treated PHIV+ children appear to have higher levels of Lp(a) compared with ethnicity-matched controls, which may implicate higher CVD risk in this population. Future research should focus on the association between Lp(a) and (sub)clinical CVD measurements in cART-treated PHIV+ patients.Dutch trial register numberNRT4074.

Published
2019

2. GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia

Author

Hu, Xuchen, Dallinga-Thie, Geesje M, Hovingh, G Kees, Chang, Sandy Y, Sandoval, Norma P, Dang, Tiffany Ly P, Fukamachi, Isamu, Miyashita, Kazuya, Nakajima, Katsuyuki, Murakami, Masami, Fong, Loren G, Ploug, Michael, Young, Stephen G, and Beigneux, Anne P

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Autoimmune Disease, 2.1 Biological and endogenous factors, Aetiology, Adult, Animals, Autoantibodies, Cell Line, Humans, Hyperlipoproteinemia Type I, Hypertriglyceridemia, Male, Mutation, Receptors, Lipoprotein, Chylomicrons, Endothelial cells, Intravascular lipolysis, Lipids, Triglycerides, Medical Biochemistry and Metabolomics, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Medical biochemistry and metabolomics
Abstract

BackgroundGPIHBP1, a glycolipid-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) in the interstitial spaces and transports it to the capillary lumen. GPIHBP1 deficiency prevents LPL from reaching the capillary lumen, resulting in low intravascular LPL levels, impaired intravascular triglyceride processing, and severe hypertriglyceridemia (chylomicronemia). A recent study showed that some cases of hypertriglyceridemia are caused by autoantibodies against GPIHBP1 ("GPIHBP1 autoantibody syndrome").ObjectiveOur objective was to gain additional insights into the frequency of the GPIHBP1 autoantibody syndrome in patients with unexplained chylomicronemia.MethodsWe used enzyme-linked immunosorbent assays to screen for GPIHBP1 autoantibodies in 33 patients with unexplained chylomicronemia and then used Western blots and immunocytochemistry studies to characterize the GPIHBP1 autoantibodies.ResultsThe plasma of 1 patient, a 36-year-old man with severe hypertriglyceridemia, contained GPIHBP1 autoantibodies. The autoantibodies, which were easily detectable by Western blot, blocked the ability of GPIHBP1 to bind LPL. The plasma levels of LPL mass and activity were low. The patient had no history of autoimmune disease, but his plasma was positive for antinuclear antibodies.ConclusionsOne of 33 patients with unexplained chylomicronemia had the GPIHBP1 autoantibody syndrome. Additional studies in large lipid clinics will be helpful for better defining the frequency of this syndrome and for exploring the best strategies for treatment.

Published
2017

8. Carriers of Loss-of-Function Mutations in EXT Display Impaired Pancreatic Beta-Cell Reserve Due to Smaller Pancreas Volume

Author

Moens, Sophie J Bernelot, Mooij, Hans L, Hassing, H Carlijne, Kruit, Janine K, Witjes, Julia J, van de Sande, Michiel AJ, Nederveen, Aart J, Xu, Ding, Dallinga-Thie, Geesje M, Esko, Jeffrey D, Stroes, Erik SG, and Nieuwdorp, Max

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Diabetes, Biomedical Imaging, Clinical Research, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Adult, Case-Control Studies, Exostoses, Multiple Hereditary, Female, Glucose, Homozygote, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Male, Middle Aged, Mutation, N-Acetylglucosaminyltransferases, General Science & Technology
Abstract

Exotosin (EXT) proteins are involved in the chain elongation step of heparan sulfate (HS) biosynthesis, which is intricately involved in organ development. Loss of function mutations (LOF) in EXT1 and EXT2 result in hereditary exostoses (HME). Interestingly, HS plays a role in pancreas development and beta-cell function, and genetic variations in EXT2 are associated with an increased risk for type 2 diabetes mellitus. We hypothesized that loss of function of EXT1 or EXT2 in subjects with hereditary multiple exostoses (HME) affects pancreatic insulin secretion capacity and development. We performed an oral glucose tolerance test (OGTT) followed by hyperglycemic clamps to investigate first-phase glucose-stimulated insulin secretion (GSIS) in HME patients and age and gender matched non-affected relatives. Pancreas volume was assessed with magnetic resonance imaging (MRI). OGTT did not reveal significant differences in glucose disposal, but there was a markedly lower GSIS in HME subjects during hyperglycemic clamp (iAUC HME: 0.72 [0.46-1.16] vs. controls 1.53 [0.69-3.36] nmol·l-1·min-1, p

Published
2014

9. Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume.

Author

Bernelot Moens, Sophie J, Mooij, Hans L, Hassing, H Carlijne, Kruit, Janine K, Witjes, Julia J, van de Sande, Michiel AJ, Nederveen, Aart J, Xu, Ding, Dallinga-Thie, Geesje M, Esko, Jeffrey D, Stroes, Erik SG, and Nieuwdorp, Max

Subjects
Humans, Exostoses, Multiple Hereditary, Insulin, N-Acetylglucosaminyltransferases, Glucose, Case-Control Studies, Homozygote, Mutation, Adult, Middle Aged, Female, Male, Insulin-Secreting Cells, Insulin Secretion, Exostoses, Multiple Hereditary, General Science & Technology
Abstract

Exotosin (EXT) proteins are involved in the chain elongation step of heparan sulfate (HS) biosynthesis, which is intricately involved in organ development. Loss of function mutations (LOF) in EXT1 and EXT2 result in hereditary exostoses (HME). Interestingly, HS plays a role in pancreas development and beta-cell function, and genetic variations in EXT2 are associated with an increased risk for type 2 diabetes mellitus. We hypothesized that loss of function of EXT1 or EXT2 in subjects with hereditary multiple exostoses (HME) affects pancreatic insulin secretion capacity and development. We performed an oral glucose tolerance test (OGTT) followed by hyperglycemic clamps to investigate first-phase glucose-stimulated insulin secretion (GSIS) in HME patients and age and gender matched non-affected relatives. Pancreas volume was assessed with magnetic resonance imaging (MRI). OGTT did not reveal significant differences in glucose disposal, but there was a markedly lower GSIS in HME subjects during hyperglycemic clamp (iAUC HME: 0.72 [0.46-1.16] vs. controls 1.53 [0.69-3.36] nmol·l-1·min-1, p

Published
2014

10. Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial

Author

de Groot, Pieter F., Nikolic, Tatjana, Imangaliyev, Sultan, Bekkering, Siroon, Duinkerken, Gaby, Keij, Fleur M., Herrema, Hilde, Winkelmeijer, Maaike, Kroon, Jeffrey, Levin, Evgeni, Hutten, Barbara, Kemper, Elles M., Simsek, Suat, Levels, Johannes H. M., van Hoorn, Flora A., Bindraban, Renuka, Berkvens, Alicia, Dallinga-Thie, Geesje M., Davids, Mark, Holleman, Frits, Hoekstra, Joost B. L., Stroes, Erik S. G., Netea, Mihai, van Raalte, Daniël H., Roep, Bart O., and Nieuwdorp, Max

Published
2020
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11. Role of Transcription Factor KLF11 and Its Diabetes-Associated Gene Variants in Pancreatic Beta Cell Function

Author

Neve, Bernadette, Fernandez-Zapico, Martin E., Ashkenazi-Katalan, Vered, Dina, Christian, Hamid, Yasmin H., Joly, Erik, Vaillant, Emmanuel, Benmezroua, Yamina, Durand, Emmanuelle, Bakaher, Nicolas, Delannoy, Valerie, Vaxillaire, Martine, Cook, Tiffany, Dallinga-Thie, Geesje M., Jansen, Hans, Charles, Marie-Aline, Clément, Karine, Galan, Pilar, Hercberg, Serge, Helbecque, Nicole, Charpentier, Guillaume, Prentki, Marc, Hansen, Torben, Pedersen, Oluf, Urrutia, Raul, Melloul, Danielle, Froguel, Philippe, and Steiner, Donald F.

Published
2005

14. Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Author

Kootte, Ruud S., Levin, Evgeni, Salojärvi, Jarkko, Smits, Loek P., Hartstra, Annick V., Udayappan, Shanti D., Hermes, Gerben, Bouter, Kristien E., Koopen, Annefleur M., Holst, Jens J., Knop, Filip K., Blaak, Ellen E., Zhao, Jing, Smidt, Hauke, Harms, Amy C., Hankemeijer, Thomas, Bergman, Jacques J.G.H.M., Romijn, Hans A., Schaap, Frank G., Olde Damink, Steven W.M., Ackermans, Mariette T., Dallinga-Thie, Geesje M., Zoetendal, Erwin, de Vos, Willem M., Serlie, Mireille J., Stroes, Erik S.G., Groen, Albert K., and Nieuwdorp, Max

Published
2017
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15. Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans

Author

Loaiza, Natalia, Hartgers, Merel L., Reeskamp, Laurens F., Balder, Jan-Willem, Rimbert, Antoine, Bazioti, Venetia, Wolters, Justina C., Winkelmeijer, Maaike, Jansen, Hans P.G., Dallinga-Thie, Geesje M., Volta, Andrea, Huijkman, Nicolette, Smit, Marieke, Kloosterhuis, Niels, Koster, Mirjam, F. Svendsen, Arthur, van de Sluis, Bart, Hovingh, G. Kees, Grefhorst, Aldo, and Kuivenhoven, Jan Albert

Published
2020
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16. Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production

Author

Yildirim, Vehpi, primary, ter Horst, Kasper W., additional, Gilijamse, Pim W., additional, van Harskamp, Dewi, additional, Schierbeek, Henk, additional, Jansen, Hans, additional, Schimmel, Alinda W.M., additional, Nieuwdorp, Max, additional, Groen, Albert K., additional, Serlie, Mireille J., additional, van Riel, Natal A.W., additional, and Dallinga-Thie, Geesje M., additional

Published
2023
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20. N-Glycosylation Defects in Humans Lower Low-Density Lipoprotein Cholesterol Through Increased Low-Density Lipoprotein Receptor Expression

Author

van den Boogert, Marjolein A.W., Larsen, Lars E., Ali, Lubna, Kuil, Sacha D., Chong, Patrick L.W., Loregger, Anke, Kroon, Jeffrey, Schnitzler, Johan G., Schimmel, Alinda W.M., Peter, Jorge, Levels, Johannes H.M., Steenbergen, Gerry, Morava, Eva, Dallinga-Thie, Geesje M., Wevers, Ron A., Kuivenhoven, Jan Albert, Hand, Nicholas J., Zelcer, Noam, Rader, Daniel J., Stroes, Erik S.G., Lefeber, Dirk J., and Holleboom, Adriaan G.

Published
2019
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21. Bariatric surgery improves postprandial VLDL kinetics and restores insulin mediated regulation of hepatic VLDL production

Author

Yildirim, Vehpi, Ter Horst, Kasper W., Gilijamse, Pim W., van Harskamp, Dewi, Schierbeek, Henk, Jansen, Hans, Schimmel, Alinda, Nieuwdorp, Max, Groen, Albert K., Serlie, Mireille J., van Riel, Natal A.W., Dallinga-Thie, Geesje M., Yildirim, Vehpi, Ter Horst, Kasper W., Gilijamse, Pim W., van Harskamp, Dewi, Schierbeek, Henk, Jansen, Hans, Schimmel, Alinda, Nieuwdorp, Max, Groen, Albert K., Serlie, Mireille J., van Riel, Natal A.W., and Dallinga-Thie, Geesje M.

Abstract

Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state. Here, we investigated the impact of Roux-en-Y gastric bypass (RYGB) surgery on postprandial VLDL1 and VLDL2 apoB and TG kinetics and their relationship with insulin-responsiveness indices. Morbidly obese patients without diabetes who were scheduled for RYGB surgery (n = 24) underwent a lipoprotein kinetics study during a mixed-meal test and a hyperinsulinemic-euglycemic clamp study before the surgery and 1 year later. A physiologically based computational model was developed to investigate the impact of RYGB surgery and plasma insulin on postprandial VLDL kinetics. After the surgery, VLDL1 apoB and TG production rates were significantly decreased, whereas VLDL2 apoB and TG production rates remained unchanged. The TG catabolic rate was increased in both VLDL1 and VLDL2 fractions, but only the VLDL2 apoB catabolic rate tended to increase. Furthermore, postsurgery VLDL1 apoB and TG production rates, but not those of VLDL2, were positively correlated with insulin resistance. Insulin-mediated stimulation of peripheral lipoprotein lipolysis was also improved after the surgery. In summary, RYGB resulted in reduced hepatic VLDL1 production that correlated with reduced insulin resistance, elevated VLDL2 clearance, and improved insulin sensitivity in lipoprotein lipolysis pathways.

Published
2023

22. Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

Author

van der Valk, Fleur M., van Wijk, Diederik F., Lobatto, Mark E., Verberne, Hein J., Storm, Gert, Willems, Martine C.M., Legemate, Dink A., Nederveen, Aart J., Calcagno, Claudia, Mani, Venkatesh, Ramachandran, Sarayu, Paridaans, Maarten P.M., Otten, Maarten J., Dallinga-Thie, Geesje M., Fayad, Zahi A., Nieuwdorp, Max, Schulte, Dominik M., Metselaar, Josbert M., Mulder, Willem J.M., and Stroes, Erik S.

Published
2015
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26. Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

Author

Vrieze, Anne, Out, Carolien, Fuentes, Susana, Jonker, Lisanne, Reuling, Isaie, Kootte, Ruud S., van Nood, Els, Holleman, Frits, Knaapen, Max, Romijn, Johannes A., Soeters, Maarten R., Blaak, Ellen E., Dallinga-Thie, Geesje M., Reijnders, Dorien, Ackermans, Mariëtte T., Serlie, Mireille J., Knop, Filip K., Holst, Jenst J., van der Ley, Claude, Kema, Ido P., Zoetendal, Erwin G., de Vos, Willem M., Hoekstra, Joost B.L., Stroes, Erik S., Groen, Albert K., and Nieuwdorp, Max

Published
2014
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27. Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor–Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans

Author

Oldoni, Federico, van Capelleveen, Julian C., Dalila, Nawar, Wolters, Justina C., Heeren, Joerg, Sinke, Richard J., Hui, David Y., Dallinga-Thie, Geesje M., Frikke-Schmidt, Ruth, Hovingh, Kees G., van de Sluis, Bart, Tybjærg-Hansen, Anne, and Kuivenhoven, Jan Albert

Published
2018
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36. ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels

Author

Trigueros-Motos, Laia, van Capelleveen, Julian C., Torta, Federico, Castaño, David, Zhang, Lin-Hua, Chai, Ee Chu, Kang, Martin, Dimova, Lidiya G., Schimmel, Alinda W.M., Tietjen, Ian, Radomski, Chris, Tan, Liang Juin, Thiam, Chung Hwee, Narayanaswamy, Pradeep, Wu, Daniel Heqing, Dorninger, Fabian, Yakala, Gopala Krishna, Barhdadi, Amina, Angeli, Veronique, Dubé, Marie-Pierre, Berger, Johannes, Dallinga-Thie, Geesje M., Tietge, Uwe J.F., Wenk, Markus R., Hayden, Michael R., Hovingh, G. Kees, and Singaraja, Roshni R.

Published
2017
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37. Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

Author

Vrieze, Anne, Van Nood, Els, Holleman, Frits, Salojärvi, Jarkko, Kootte, Ruud S., Bartelsman, Joep F.W.M., Dallinga–Thie, Geesje M., Ackermans, Mariette T., Serlie, Mireille J., Oozeer, Raish, Derrien, Muriel, Druesne, Anne, Van Hylckama Vlieg, Johan E.T., Bloks, Vincent W., Groen, Albert K., Heilig, Hans G.H.J., Zoetendal, Erwin G., Stroes, Erik S., de Vos, Willem M., Hoekstra, Joost B.L., and Nieuwdorp, Max

Published
2012
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40. Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia

Author

Kulozik, Philipp, Jones, Allan, Mattijssen, Frits, Rose, Adam J., Reimann, Anja, Strzoda, Daniela, Kleinsorg, Stefan, Raupp, Christina, Kleinschmidt, Jürgen, Müller-Decker, Karin, Wahli, Walter, Sticht, Carsten, Gretz, Norbert, von Loeffelholz, Christian, Stockmann, Martin, Pfeiffer, Andreas, Stöhr, Sigrid, Dallinga-Thie, Geesje M., Nawroth, Peter P., Diaz, Mauricio Berriel, and Herzig, Stephan

Published
2011
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41. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

Author

Hoeksema, Marten A, Gijbels, Marion JJ, Van den Bossche, Jan, van der Velden, Saskia, Sijm, Ayestha, Neele, Annette E, Seijkens, Tom, Stöger, J Lauran, Meiler, Svenja, Boshuizen, Marieke CS, Dallinga‐Thie, Geesje M, Levels, Johannes HM, Boon, Louis, Mullican, Shannon E, Spann, Nathanael J, Cleutjens, Jack P, Glass, Chris K, Lazar, Mitchell A, de Vries, Carlie JM, Biessen, Erik AL, Daemen, Mat JAP, Lutgens, Esther, and de Winther, Menno PJ

Published
2014
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46. Fasting cholesteryl ester transfer protein concentration is independently associated with the postprandial decrease in high-density lipoprotein cholesterol concentration after fat-rich meals: the Hoorn prandial study

Author

Alssema, Marjan, El-Harchaoui, Karim, Schindhelm, Roger K., Diamant, Michaela, Nijpels, Giel, Kostense, Piet J., Teerlink, Tom, Heine, Robert J., Dallinga-Thie, Geesje M., Kuivenhoven, Jan A., Dekker, Jacqueline M., and Scheffer, Peter G.

Published
2010
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