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3. PLANETARY SCIENCE: The Pluto system: Initial results from its exploration by New Horizons

Author

Stern, S. A., Bagenal, F., Ennico, K., Gladstone, G. R., Grundy, W. M., McKinnon, W. B., Moore, J. M., Olkin, C. B., Spencer, J. R., Weaver, H. A., Young, L. A., Andert, T., Andrews, J., Banks, M., Bauer, B., Bauman, J., Barnouin, O. S., Bedini, P., Beisser, K., Beyer, R. A., Bhaskaran, S., Binzel, R. P., Birath, E., Bird, M., Bogan, D. J., Bowman, A., Bray, V. J., Brozovic, M., Bryan, C., Buckley, M. R., Buie, M. W., Buratti, B. J., Bushman, S. S., Calloway, A., Carcich, B., Cheng, A. F., Conard, S., Conrad, C. A., Cook, J. C., Cruikshank, D. P., Custodio, O. S., Ore, Dalle C. M., Deboy, C., Dischner, Z. J. B., Dumont, P., Earle, A M., Elliott, H. A, Ercol, J., Ernst, C. M., Finley, T., Flanigan, S. H., Fountain, G., Freeze, M. J., Greathouse, T., Green, J. L., Guo, Y., Hahn, M., Hamilton, D. P., Hamilton, S. A., Hanley, J., Harch, A., Hart, H. M., Hersman, C. B., Hill, A., Hill, M. E., Hinson, D. P., Holdridge, M. E., Horanyi, M., Howard, A. D., Howett, C. J. A., Jackman, C., Jacobson, R. A., Jennings, D. E., Kammer, J. A., Kang, H. K., Kaufmann, D. E., Kollmann, P., Krimigis, S. M., Kusnierkiewicz, D., Lauer, T. R., Lee, J. E., Lindstrom, K. L., Linscott, I. R., Lisse, C. M., Lunsford, A. W., Mallder, V. A., Martin, N., McComas, D. J., McNutt, R. L., Jr., Mehoke, D., Mehoke, T., Melin, E. D., Mutchler, M., Nelson, D., Nimmo, F., Nunez, J. I., Ocampo, A., Owen, W. M., Paetzold, M., Page, B., Parker, A. H., Parker, J. W., Pelletier, F., Peterson, J., Pinkine, N., Piquette, M., Porter, S. B., Protopapa, S., Redfern, J., Reitsema, H. J., Reuter, D. C., Roberts, J. H., Bobbins, S. J., Rogers, G., Rose, D., Runyon, K., Retherford, K. D., Ryschkewitsch, M. G., Schenk, P., Schindhelm, E., Sepan, B., Showalter, M. R., Singer, K. N., Soluri, M., Stanbridge, D., Steffl, A. J., Strobel, D. F., Stryk, T., Summers, M. E., Szalay, J. R., Tapley, M., Taylor, A., Taylor, H., Throop, H. B., Tsang, C. C. C., Tyler, G. L., Umurhan, O. M., Verbiscer, A. J., Versteeg, M. H., Vincent, M., Webbert, R., Weidner, S., Weigle, G. E., II, White, O. L., Whittenburg, K., Williams, B. G., Williams, K., Williams, S., Woods, W. W., Zangari, A. M., and Zirnstein, E.

Published
2015
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6. 3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro

Author

Maïza, A., Sidahmed-Adrar, N., Michel, P.P., Carpentier, G., Habert, D., Dalle, C., Redouane, W., Hamza, M., Kuppevelt, T.H. van, Ouidja, M.O., Courty, J., Chantepie, S., Papy-Garcia, D., Stettler, O., Maïza, A., Sidahmed-Adrar, N., Michel, P.P., Carpentier, G., Habert, D., Dalle, C., Redouane, W., Hamza, M., Kuppevelt, T.H. van, Ouidja, M.O., Courty, J., Chantepie, S., Papy-Garcia, D., and Stettler, O.

Abstract

Contains fulltext : 229011.pdf (publisher's version ) (Open Access), Heparan sulfate (HS) chains, covalently linked to heparan sulfate proteoglycans (HSPG), promote synaptic development and functions by connecting various synaptic adhesion proteins (AP). HS binding to AP could vary according to modifications of HS chains by different sulfotransferases. 3-O-sulfotransferases (Hs3sts) produce rare 3-O-sulfated HSs (3S-HSs), of poorly known functions in the nervous system. Here, we showed that a peptide known to block herpes simplex virus by interfering with 3S-HSs in vitro and in vivo (i.e. G2 peptide), specifically inhibited neural activity, reduced evoked glutamate release, and impaired synaptic assembly in hippocampal cell cultures. A role for 3S-HSs in promoting synaptic assembly and neural activity is consistent with the synaptic interactome of G2 peptide, and with the detection of Hs3sts and their products in synapses of cultured neurons and in synaptosomes prepared from developing brains. Our study suggests that 3S-HSs acting as receptors for herpesviruses might be important regulators of neuronal and synaptic development in vertebrates.

Published
2020

9. Modeling of microwave top illuminated PIN photodetector under very high optical power

Author

Harari, J., Jin, G.H., Journet, F., Vandecasteele, J., Vilcot, J.P., Dalle, C., Friscourt, M.R., and Decoster, D.

Subjects
Photodetectors -- Models, Light-emitting diodes -- Models, Electron mobility -- Models, Business, Computers, Electronics, Electronics and electrical industries
Abstract

In this paper, we present a theoretical study and a numerical simulation of a classical long wavelength top illuminated PIN photodetector for microwave applications under very high optical power. The modeling includes a monodimensional drift-diffusion model for the device and takes into account the external circuit. At first, this modeling is validated using experimental results from the literature. Second, we consider a classical InP/GaInAs/InP photodiode grown on [N.sup.+] InP substrate. The presented results show that the distortion and the saturation of the microwave signal at 20 GHz are due to the space F charge effect in the photodetector and also to the depolarization of the device because of the external circuit. The main parameter influencing these phenomena are the optical power, the bias voltage, the optical spot c width and the modulation depth. In case of small optical spot, the effect of the external circuit is neglectable, while it contributes to the decrease of the microwave responsivity in case of large spot. The maximum output power is calculated in different cases and we can expect up to 12 dBm microwave output power for a 5 V reverse bias voltage.

Published
1996

11. Signatures métabolomiques associés à des profils alimentaires spécifiques dans la cohorte SU.VI.MAX

Author

Lécuyer, L., primary, Dalle, C., additional, Micheau, P., additional, Pétéra, M., additional, Centeno, D., additional, Lyan, B., additional, Morand, C., additional, Galan, P., additional, Hercberg, S., additional, Rossary, A., additional, Demidem, A., additional, Vasson, M.-P., additional, Partula, V., additional, Deschasaux, M., additional, Srour, B., additional, Latino-Martel, P., additional, Kesse-Guyot, E., additional, Durand, S., additional, Pujos-Guillot, E., additional, Manach, C., additional, and Mathilde, T., additional

Published
2019
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12. HCN1 mutation spectrum: From neonatal epileptic encephalopathy to benign generalized epilepsy and beyond

Author

Marini, C, Porro, A, Rastetter, A, Dalle, C, Rivolta, I, Bauer, D, Oegema, R, Nava, C, Parrini, E, Mei, D, Mercer, C, Dhamija, R, Chambers, C, Coubes, C, Thévenon, J, Kuentz, P, Julia, S, Pasquier, L, Dubourg, C, Carré, W, Rosati, A, Melani, F, Pisano, T, Giardino, M, Innes, A, Alembik, Y, Scheidecker, S, Santos, M, Figueiroa, S, Garrido, C, Fusco, C, Frattini, D, Spagnoli, C, Binda, A, Granata, T, Ragona, F, Freri, E, Franceschetti, S, Canafoglia, L, Castellotti, B, Gellera, C, Milanesi, R, Mancardi, M, Clark, D, Kok, F, Helbig, K, Ichikawa, S, Sadler, L, Neupauerová, J, Laššuthova, P, Šterbová, K, Laridon, A, Brilstra, E, Koeleman, B, Lemke, J, Zara, F, Striano, P, Soblet, J, Smits, G, Deconinck, N, Barbuti, A, Difrancesco, D, Leguern, E, Guerrini, R, Santoro, B, Hamacher, K, Thiel, G, Moroni, A, Di Francesco, J, Depienne, C, Innes, AM, Mancardi, MM, Clark, DR, Helbig, KL, Lemke, JR, DiFrancesco, D, LeGuern, E, Di Francesco, JC, Marini, C, Porro, A, Rastetter, A, Dalle, C, Rivolta, I, Bauer, D, Oegema, R, Nava, C, Parrini, E, Mei, D, Mercer, C, Dhamija, R, Chambers, C, Coubes, C, Thévenon, J, Kuentz, P, Julia, S, Pasquier, L, Dubourg, C, Carré, W, Rosati, A, Melani, F, Pisano, T, Giardino, M, Innes, A, Alembik, Y, Scheidecker, S, Santos, M, Figueiroa, S, Garrido, C, Fusco, C, Frattini, D, Spagnoli, C, Binda, A, Granata, T, Ragona, F, Freri, E, Franceschetti, S, Canafoglia, L, Castellotti, B, Gellera, C, Milanesi, R, Mancardi, M, Clark, D, Kok, F, Helbig, K, Ichikawa, S, Sadler, L, Neupauerová, J, Laššuthova, P, Šterbová, K, Laridon, A, Brilstra, E, Koeleman, B, Lemke, J, Zara, F, Striano, P, Soblet, J, Smits, G, Deconinck, N, Barbuti, A, Difrancesco, D, Leguern, E, Guerrini, R, Santoro, B, Hamacher, K, Thiel, G, Moroni, A, Di Francesco, J, Depienne, C, Innes, AM, Mancardi, MM, Clark, DR, Helbig, KL, Lemke, JR, DiFrancesco, D, LeGuern, E, and Di Francesco, JC

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal excitability and their dysfunction has been linked to epileptogenesis but few individuals with neurological disorders related to variants altering HCN channels have been reported so far. In 2014, we described five individuals with epileptic encephalopathy due to de novo HCN1 variants. To delineate HCN1-related disorders and investigate genotype-phenotype correlations further, we assembled a cohort of 33 unpublished patients with novel pathogenic or likely pathogenic variants: 19 probands carrying 14 different de novo mutations and four families with dominantly inherited variants segregating with epilepsy in 14 individuals, but not penetrant in six additional individuals. Sporadic patients had epilepsy with median onset at age 7 months and in 36% the first seizure occurred during a febrile illness. Overall, considering familial and sporadic patients, the predominant phenotypes were mild, including genetic generalized epilepsies and genetic epilepsy with febrile seizures plus (GEFS+) spectrum. About 20% manifested neonatal/infantile onset otherwise unclassified epileptic encephalopathy. The study also included eight patients with variants of unknown significance: One adopted patient had two HCN1 variants, four probands had intellectual disability without seizures, and three individuals had missense variants inherited from an asymptomatic parent. Of the 18 novel pathogenic missense variants identified, 12 were associated with severe phenotypes and clustered within or close to transmembrane domains, while variants segregating with milder phenotypes were located outside transmembrane domains, in the intracellular N- and C-terminal parts of the channel. Five recurrent variants were associated with similar phenotypes. Using whole-cell patch-clamp, we showed that the impact of 12 selected variants ranged from complete loss-of-function to significant shifts in activation kinetics and/or volta

Published
2018

15. Signatures métabolomiques par spectrométrie de masse et risque de cancer du sein

Author

Lécuyer, L., primary, Dalle, C., additional, Lyan, B., additional, Petera, M., additional, Lagree, M., additional, Rossary, A., additional, Demidem, A., additional, Ferreira, T., additional, Centeno, D., additional, Galan, P., additional, Hercberg, S., additional, Deschasaux, M., additional, Partula, V., additional, Srour, B., additional, Latino-Martel, P., additional, Kesse-Guyot, E., additional, Manach, C., additional, Vasson, M.-P., additional, Durand, S., additional, Pujos-Guillot, E., additional, and Touvier, M., additional

Published
2018
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16. Identification de biomarqueurs nutritionnels par une approche métabolomique en spectrométrie de masse

Author

Dalle, C., primary, Lécuyer, L., additional, Petera, M., additional, Centeno, D., additional, Lyan, B., additional, Durand, S., additional, Pujos-Guillot, E., additional, Micheau, P., additional, Morand, C., additional, Galan, P., additional, Hercberg, S., additional, Partula, V., additional, Deschasaux, M., additional, Srour, B., additional, Latino-Martel, P., additional, Kesse-Guyot, E., additional, Touvier, M., additional, and Manach, C., additional

Published
2018
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19. Modélisation physique numérique 2D/3D de composants semiconducteurs dans le domaine temporel basée sur le couplage électromagnétisme/transport

Author

Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2013

20. Series-like InP transferred electron devices for CW submillimeter-wave power pources

Author

Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2013

22. [Hypersensitivity to topical steroids]

Author

Biver-Dalle, C., Guichard, A., Vigan, M., Humbert, P., Aubin, François, Département de dermatologie, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques-Université de Franche-Comté ( UFC ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)

Subjects
Dose-Response Relationship, Drug, Hydrocortisone, Anti-Inflammatory Agents, [SDV.CAN]Life Sciences [q-bio]/Cancer, Patch Tests, Administration, Cutaneous, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, Diagnosis, Differential, Adrenal Cortex Hormones, Risk Factors, Humans, Immunologic Factors, Drug Eruptions, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012
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24. Modélisation physique numérique 2D/3D de structures semiconductrices dans le domaine temporel basée sur le couplage électromagnétisme/transport

Author

Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2012

25. Monte Carlo simulation of electrical and thermal properties of nanowire-based insulated gate transistors

Author

Sadi, T., Thobel, J.L., Dessenne, F., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2011

26. Coupled electromagnetism/transport modeling for semiconductor structure simulation

Author

Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2010

27. 3D time-domain electromagnetic/transport macroscopic numerical physical modeling - Application to mm-wave GaAs photoswitch

Author

El Moussati, A., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2009
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29. Développement d'un modèle électromagnétique numérique des composants semiconducteurs basé sur une approche physique macroscopique dans le domaine temporel. Application à la diode ATT distribuée en ondes millimétriques

Author

El Moussati, A., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2007

30. Modélisation physique numérique macroscopique pour l'étude de composants semiconducteurs distribués

Author

El Moussati, A., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2007

31. Modélisation physique macroscopique de composants semi-conducteurs pour applications thermoélectriques

Author

Dalle, C., Charef, M., Thobel, J.L., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2007

32. Modélisation physique numérique des circuits électroniques haute fréquence

Author

Dalle, C., Dessenne, F., Baudry, L., Charef, M., Thobel, J.L., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Subjects
[SPI]Engineering Sciences [physics]
Published
2007

33. Modélisation physique électromagnétique des composants semiconducteurs

Author

Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2007

34. Explicit versus implicit finite-difference approximation for semiconductor device time-domain macroscopic numerical modelling on parallel computer

Author

El Moussati, A., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2005

35. Les dipôles hyperfréquences

Author

Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and Pasquet D.

Abstract

ISBN 978-2746212053

Published
2005

40. Modèle hydrodynamique de transistors HEMTs pour la conception de circuits hyperfréquences

Author

Abdool-Raheem, M.H., Dalle, C., De Jaeger, J.C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
2003

41. EAO des circuits microondes en régime temporel : approche physique

Author

Dalle, C., Friscourt, M.R., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
1999

42. Modélisation de phototransistors bipolaires à hétérojonction Inp/InGaAs de type guide d'onde

Author

Magnin, V., Harari, J., Jin, G.H., Friscourt, M.R., Dalle, C., Rolland, P.A., Vilcot, J.P., Decoster, D., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
1997

43. Applications hyperfréquences et optoélectroniques des transistors à effet de champ à transfert électronique

Author

Driouch, F., Friscourt, M.R., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
1997

44. Characterisation of alpha 1A Ba2+, Sr2+ and Ca2+ currents recorded with the ancillary beta 1-4 subunits

Author

Mangoni, Me, Thierry Cens, Dalle, C., Nargeot, J., and Charnet, P.

Subjects
Binding Sites, Patch-Clamp Techniques, Microinjections, Xenopus, Brain, Gene Expression, Rats, Electrophysiology, Kinetics, Barium, Strontium, Oocytes, Animals, Calcium, Calcium Channels, Ion Channel Gating, Plasmids
Abstract

Xenopus oocytes have been injected with different combinations of expression plasmids carrying the rat brain alpha 1A and different beta (beta 1-4) Ca2+ channel subunit cDNAs. Whole-cell Ba2+ and Ca2+ currents were recorded up to seven days after injection. Intra-oocyte injection of BAPTA allowed us to record uncontaminated Ba2+, Sr2+ currents. The alpha 1A calcium channel showed relative current amplitudes according to the sequence: IBa2+ISr2+ICa2+. The ratio ICa2+/IBa2+ was significantly larger when compared to the class C L-type Ca2+ channel (alpha 1C). However, currents flowing through alpha 1A and alpha (1C) subunits saturate for similar Ba2+ concentrations and display the anomalous mole fraction effect in the presence of mixtures of Ba2+ and Ca2+ ions in the external medium. In oocytes expressing the alpha 1A Ca2+ channel subunit, switching from extracellular Ba2+ to Ca2+ also induced a depolarising shift of current-to-voltage relation and the steady-state inactivation curve, and increased the time-to-peak of the current. Inactivation kinetics were poorly affected. Changes in gating and voltage-dependence of activation, but not in the voltage-dependent inactivation, were independent from the coexpressed beta subunit (except with the beta 4 subunit). Our data constitute strong evidence for the existence of differences in intra-pore Ca2+ binding sites between the alpha 1C and alpha 1A subunits, and emphasise the influence of the charge carrier on the modulation of alpha 1A properties by the beta subunits.

Published
1997

45. Radar millimétrique de courte portée à impulsions de conception simple à diode Gunn planaire à injection MESFET

Author

Driouch, F., Friscourt, M.R., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Published
1997

46. Modélisation d'un oscillateur pulsé basée sur le couplage de modèles physique, électrique, thermique et électromagnétique

Author

Beaussart, S., Friscourt, M.R., Dalle, C., Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Subjects
[SPI]Engineering Sciences [physics]
Published
1997

47. UV-induced reaction of H2 with the core of germanosilicate and aluminosilicate fiber preforms

Author

Dalle, C., Cordier, P., Depecker, C., Bernage, P., Douay, M., Niay, P., Bayon, J.F., and Dong, L.

Abstract

The photosensitivity of glasses can be significantly enhanced by high- pressure low-temperature hydrogen loading prior to UV exposure. The chemical reactions that occur between hydrogen and glass under UV exposure are thus of primary importance for the understanding of the mechanisms of H2 photosensitivity enhancement. We have used infrared spectroscopy to characterize the microstructural modifications in Hz-loaded optical fiber preform cores exposed to UV laser light. Infrared spectroscopy in the 3µm range is very well adapted to such a characterization because it is highly sensitive to hydroxyl groups.

Published
1997
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