19 results on '"Dali Sui"'
Search Results
2. Postoperative Long-Term Independence Among the Elderly With Meningiomas: Function Evolution, Determinant Identification, and Prediction Model Development
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Haoyi Li, Huawei Huang, Xiaokang Zhang, Yonggang Wang, Xiaohui Ren, Yong Cui, Dali Sui, Song Lin, Zhongli Jiang, and Guobin Zhang
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independence ,meningioma ,the elderly ,functional evolution ,prediction model ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundMaintenance of postoperative long-term independence has value for older adults who undergo surgical procedures. However, independence has barely caught attention for the elderly with meningiomas. Preventing postoperative long-term independence decline in this population necessitates the identification of the factors related to this outcome and minimizing their implications. Therefore, we assessed the independence evolution and identified potential determinants and population.Materials and MethodsFrom 2010 to 2016, elderly meningioma patients (≥65 years old) undergoing operation at Beijing Tiantan Hospital were included in our study. The primary outcome was 3-year (i.e., long-term) postoperative independence measured by Karnofsky performance scale (KPS) score. We used univariate and multivariate analyses to determine the risk factors for postoperative long-term independence, and nomogram was established.ResultsA total of 470 patients were included eligibly. The distribution in each KPS was significantly different before and 3 years after resection (P < 0.001). Especially in patients with preoperative KPS 80 and 70, only 17.5 and 17.3% of the patients kept the same KPS after 3 years, and the remaining patients experienced significant polarization. The most common remaining symptom cluster correlated with postoperative long-term independence included fatigue (R = −0.795), memory impairment (R = −0.512), motor dysfunction (R = −0.636) and communication deficits (R = −0.501). Independent risk factors for postoperative long-term non-independence included: advanced age (70–74 vs. 65–69 OR: 2.631; 95% CI: 1.545–4.481 and ≥75 vs. 65–69 OR: 3.833; 95% CI: 1.667–8.812), recurrent meningioma (OR: 7.791; 95% CI: 3.202–18.954), location in the skull base (OR: 2.683; 95% CI: 1.383–5.205), tumor maximal diameter >6 cm (OR: 3.089; 95% CI: 1.471–6.488), nerves involved (OR: 3.144; 95% CI: 1.585–6.235), high risk of WHO grade and biological behavior (OR: 2.294; 95% CI: 1.193–4.408), recurrence during follow-up (OR: 10.296; 95% CI: 3.253–32.585), lower preoperative KPS (OR: 0.964; 95% CI: 0.938–0.991) and decreased KPS on discharge (OR: 0.967; 95% CI: 0.951–0.984) (P < 0.05). The discrimination and calibration of the nomogram revealed good predictive ability (C-index: 0.810).ConclusionElderly meningioma patients might present significant polarization trend in maintaining long-term independence after surgery. Our findings will be helpful for guiding surgical management for the elderly with meningioma and provide proposals for early functional rehabilitation.
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- 2021
- Full Text
- View/download PDF
3. Co-deletion of chromosome 1p/19q and IDH1/2 mutation in glioma subsets of brain tumors in Chinese patients.
- Author
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Xiaohui Ren, Xiangli Cui, Song Lin, Junmei Wang, Zhongli Jiang, Dali Sui, Jing Li, and Zhongcheng Wang
- Subjects
Medicine ,Science - Abstract
OBJECTIVE: To characterize co-deletion of chromosome 1p/19q and IDH1/2 mutation in Chinese brain tumor patients and to assess their associations with clinical features. METHODS: In a series of 528 patients with gliomas, pathological and radiological materials were reviewed. Pathological constituents of tumor subsets, incidences of 1p/19q co-deletion and IDH1/2 mutation in gliomas by regions and sides in the brain were analyzed. RESULTS: Overall, 1p and 19q was detected in 339 patients by FISH method while the sequence of IDH1/2 was determined in 280 patients. Gliomas of frontal, temporal and insular origin had significantly different pathological constituents of tumor subsets (P
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- 2012
- Full Text
- View/download PDF
4. Postoperative Long-Term Independence Among the Elderly With Meningiomas: Function Evolution, Determinant Identification, and Prediction Model Development
- Author
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Guobin Zhang, Yonggang Wang, Xiaokang Zhang, Haoyi Li, Yong Cui, Dali Sui, Zhongli Jiang, Xiaohui Ren, Song Lin, and Hua-Wei Huang
- Subjects
Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,media_common.quotation_subject ,Population ,independence ,functional evolution ,meningioma ,lcsh:RC254-282 ,Resection ,Meningioma ,Primary outcome ,Internal medicine ,medicine ,Model development ,the elderly ,education ,Original Research ,media_common ,education.field_of_study ,business.industry ,Nomogram ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Independence ,prediction model ,Oncology ,business - Abstract
BackgroundMaintenance of postoperative long-term independence has value for older adults who undergo surgical procedures. However, independence has barely caught attention for the elderly with meningiomas. Preventing postoperative long-term independence decline in this population necessitates the identification of the factors related to this outcome and minimizing their implications. Therefore, we assessed the independence evolution and identified potential determinants and population.Materials and MethodsFrom 2010 to 2016, elderly meningioma patients (≥65 years old) undergoing operation at Beijing Tiantan Hospital were included in our study. The primary outcome was 3-year (i.e., long-term) postoperative independence measured by Karnofsky performance scale (KPS) score. We used univariate and multivariate analyses to determine the risk factors for postoperative long-term independence, and nomogram was established.ResultsA total of 470 patients were included eligibly. The distribution in each KPS was significantly different before and 3 years after resection (P < 0.001). Especially in patients with preoperative KPS 80 and 70, only 17.5 and 17.3% of the patients kept the same KPS after 3 years, and the remaining patients experienced significant polarization. The most common remaining symptom cluster correlated with postoperative long-term independence included fatigue (R = −0.795), memory impairment (R = −0.512), motor dysfunction (R = −0.636) and communication deficits (R = −0.501). Independent risk factors for postoperative long-term non-independence included: advanced age (70–74 vs. 65–69 OR: 2.631; 95% CI: 1.545–4.481 and ≥75 vs. 65–69 OR: 3.833; 95% CI: 1.667–8.812), recurrent meningioma (OR: 7.791; 95% CI: 3.202–18.954), location in the skull base (OR: 2.683; 95% CI: 1.383–5.205), tumor maximal diameter >6 cm (OR: 3.089; 95% CI: 1.471–6.488), nerves involved (OR: 3.144; 95% CI: 1.585–6.235), high risk of WHO grade and biological behavior (OR: 2.294; 95% CI: 1.193–4.408), recurrence during follow-up (OR: 10.296; 95% CI: 3.253–32.585), lower preoperative KPS (OR: 0.964; 95% CI: 0.938–0.991) and decreased KPS on discharge (OR: 0.967; 95% CI: 0.951–0.984) (P < 0.05). The discrimination and calibration of the nomogram revealed good predictive ability (C-index: 0.810).ConclusionElderly meningioma patients might present significant polarization trend in maintaining long-term independence after surgery. Our findings will be helpful for guiding surgical management for the elderly with meningioma and provide proposals for early functional rehabilitation.
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- 2021
5. Circulating tumor cell is a common property of brain glioma and promotes the monitoring system
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Dali Sui, Haihui Jiang, Jizong Zhao, Zhongli Jiang, Song Lin, Yong Cui, Yonggang Wang, and Faliang Gao
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Adult ,Male ,0301 basic medicine ,Treatment response ,Pathology ,medicine.medical_specialty ,Brain glioma ,radionecrosis ,Polyploidy ,03 medical and health sciences ,0302 clinical medicine ,Circulating tumor cell ,Glioma ,medicine ,Humans ,neoplasms ,Pathological ,Aged ,Brain Neoplasms ,business.industry ,Monitoring system ,Middle Aged ,Neoplastic Cells, Circulating ,medicine.disease ,nervous system diseases ,Biomarker (cell) ,030104 developmental biology ,monitor ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,biomarker ,Common property ,Female ,Neoplasm Recurrence, Local ,circulating tumor cell (CTC) ,business ,Chromosomes, Human, Pair 8 ,Research Paper - Abstract
Brain glioma is the most common primary intracranial tumor characterized by dismal prognosis and frequent recurrence, yet a real-time and reliable biological approach to monitor tumor response and progression is still lacking. Recently, few studies have reported that circulating tumor cells (CTCs) could be detected in glioblastoma multiform (GBM), providing the possibility of its application in brain glioma monitoring system. But its application limits still exist, because the detection rate of CTCs is still low and was exclusively limited to high- grade gliomas. Here, we adopted an advanced integrated cellular and molecular approach of SE-iFISH to detect CTCs in the peripheral blood (PB) of patients with 7 different subtypes of brain glioma, uncovering the direct evidences of glioma migration. We identified CTCs in the PB from 24 of 31 (77%) patients with glioma in all 7 subtypes. No statistical difference of CTC incidence and count was observed in different pathological subtypes or WHO grades of glioma. Clinical data revealed that CTCs, to some extent, was superior to MRI in monitoring the treatment response and differentiating radionecrosis from recurrence of glioma. Conclusively, CTCs is a common property of brain gliomas of various pathological subtypes, which has provided an ultimate paradox for the hypothesis “soil and seed”. It can be used to monitor the microenvironment of gliomas dynamically, which will be a meaningful complement to radiographic imaging.
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- 2016
6. Combination of intraoperative embolisation with surgical resection for treatment of giant cerebral arteriovenous malformations
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Jizong, Zhao, Shuo, Wang, Jingsheng, Li, Dali, Sui, Yuanli, Zhao, and Yan, Zhang
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- 2000
- Full Text
- View/download PDF
7. Analysis of CD137L and IL-17 Expression in Tumor Tissue as Prognostic Indicators for Gliblastoma
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Zhi-gang Zhao, Qiming Huang, Dali Sui, Song Lin, Xiaohui Ren, Jiazhen Qin, Zhenguang Wang, Limin Hao, Zhiqin Xu, Xiangli Cui, and Li Shen
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CD137L ,Oncology ,medicine.medical_specialty ,overall survival ,Kaplan-Meier Estimate ,Biology ,Applied Microbiology and Biotechnology ,Glioma ,Internal medicine ,medicine ,Humans ,Molecular Biology ,Survival rate ,Ecology, Evolution, Behavior and Systematics ,Proportional Hazards Models ,Proportional hazards model ,Mortality rate ,Interleukin-17 ,glioblastoma ,Cell Biology ,Prognosis ,medicine.disease ,Immunohistochemistry ,Tumor tissue ,4-1BB Ligand ,Immunology ,Interleukin 17 ,Biomarkers ,Research Paper ,Developmental Biology ,Glioblastoma - Abstract
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability and unpredictable clinical behavior. GBM is marked by an extremely poor prognosis with median overall survival of 12~14 months. In this study, we detected the CD137L-expressing cells and IL-17-expressing cells in tumor tissues resected from patients with GBM. Expression of CD137L and IL-17 were assessed by immunohistochemistry, and the prognostic value of CD137L and IL-17 expression within the tumor tissues were assessed by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection showed that positive cells of CD137L and IL-17 in glioblastoma tissue samples were 46.3% (19/ 41) and 73.2% (30/41) respectively. Expression of CD137L was not correlated with overall survival of GBM patients (P=0.594), while significantly longer survival rate was seen in patients with high expression of IL-17, compared to those with low expression of IL-17 (P=0.007). In addition, we also found that IL-17 expression was significantly correlated with Progression-free survival (PFS) (P=0.016) and death rate (P=0.01). Furthermore, multivariate Cox proportional hazard analyses revealed that IL-17 (P=0.018) and PFS (P=0.028) were independent factors affecting the overall survival probability. Kaplan-Meier analysis showed that PFS of high expression of IL-17 group were significantly longer (P=0.004) than low expression group with GBM. It is concluded that high levels of IL-17 expression in the tumor tissues may be a good prognostic marker for patients with GBM.
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- 2013
8. Analysis of CD137L and IL-17 Expression in Tumor Tissue as Prognostic Indicators for Gliblastoma
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Xiangli Cui, Zhiqin Xu, Zhigang Zhao, Dali Sui, Xiaohui Ren, Qiming Huang, Jiazhen Qin, Limin Hao, Zhenguang Wang, Li Shen, Song Lin
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lcsh:Biology (General) ,lcsh:QH301-705.5 - Abstract
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability and unpredictable clinical behavior. GBM is marked by an extremely poor prognosis with median overall survival of 12~14 months. In this study, we detected the CD137L-expressing cells and IL-17-expressing cells in tumor tissues resected from patients with GBM. Expression of CD137L and IL-17 were assessed by immunohistochemistry, and the prognostic value of CD137L and IL-17 expression within the tumor tissues were assessed by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection showed that positive cells of CD137L and IL-17 in glioblastoma tissue samples were 46.3% (19/ 41) and 73.2% (30/41) respectively. Expression of CD137L was not correlated with overall survival of GBM patients (P=0.594), while significantly longer survival rate was seen in patients with high expression of IL-17, compared to those with low expression of IL-17 (P=0.007). In addition, we also found that IL-17 expression was significantly correlated with Progression-free survival (PFS) (P=0.016) and death rate (P=0.01). Furthermore, multivariate Cox proportional hazard analyses revealed that IL-17 (P=0.018) and PFS (P=0.028) were independent factors affecting the overall survival probability. Kaplan-Meier analysis showed that PFS of high expression of IL-17 group were significantly longer (P=0.004) than low expression group with GBM. It is concluded that high levels of IL-17 expression in the tumor tissues may be a good prognostic marker for patients with GBM.
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- 2013
9. A new prognostic scoring scale for patients with primary WHO grade III gliomas based on molecular predictors
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Dali Sui, Haihui Jiang, Xiangli Cui, Xiaohui Ren, Jun Ma, Zhongli Jiang, Song Lin, and Wei Zhang
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Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Time Factors ,IDH1 ,Adolescent ,Bioinformatics ,Disease-Free Survival ,Young Adult ,Internal medicine ,Glioma ,Overall survival ,Humans ,Medicine ,Young adult ,Survival analysis ,Aged ,Retrospective Studies ,Brain Neoplasms ,business.industry ,Proportional hazards model ,Retrospective cohort study ,Middle Aged ,Who grade ,medicine.disease ,Magnetic Resonance Imaging ,Survival Analysis ,Isocitrate Dehydrogenase ,Neurology ,Chromosomes, Human, Pair 1 ,Mutation ,Regression Analysis ,Female ,Neurology (clinical) ,Chromosome Deletion ,business ,Follow-Up Studies - Abstract
This study was designed to select molecular markers associated with prognosis, and to propose a prognostic scoring scale for patients with primary WHO grade III gliomas based on these molecular predictors. A series of 83 grade III glioma patients surgically treated and pathologically confirmed in Beijing Tiantan Hospital between May 2009 and December 2010 were retrospectively reviewed in the study. Log-rank analysis was used to identify molecular markers associated with progression-free survival (PFS) and overall survival (OS), which were further assessed using Cox regression analysis. Based on the prognostic molecular markers, a scoring scale was proposed and Kaplan-Meier plots were compared between different scoring levels by Log-rank method. Age
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- 2012
10. Clinical, radiological, and pathological features of 24 atypical intracranial epidermoid cysts
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Lan-bing Yu, Yan Zhang, Siyuan Chen, Zhiyong Bi, Song Lin, Lin Luo, Zhongli Jiang, Dali Sui, Zhongcheng Wang, Xiaohui Ren, Yong Cui, and Wenqing Jia
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medicine.medical_specialty ,Pathology ,business.industry ,Radiography ,Follow up studies ,General Medicine ,Epidermoid cyst ,medicine.disease ,Mr imaging ,Radiological weapon ,otorhinolaryngologic diseases ,medicine ,In patient ,Radiology ,Mr images ,business ,neoplasms ,Pathological - Abstract
Object Most intracranial epidermoid cysts typically present with long T1 and T2 signals on MR images. Other epidermoid cysts with atypical MR images are often misdiagnosed as other diseases. In this study the authors aimed to analyze the incidence and the clinical, radiological, and pathological features of atypical epidermoid cysts. Methods Among 428 cases of intracranial epidermoid cysts that were surgically treated between 2002 and 2008 at Beijing Tiantan Hospital, cases with an atypical MR imaging appearance were chosen for analysis. Clinical and pathological parameters were recorded and compared in patients with lesions demonstrating typical and atypical MR appearance. Results An atypical epidermoid cyst accounts for 5.6% of the whole series. Radiologically, 58.3% of atypical epidermoids were misdiagnosed as other diseases. Compared with a typical epidermoid cyst, atypical epidermoid lesions were significantly larger (p = 0.016, chi-square test). Pathologically, hemorrhage was found in 21 patients with atypical epidermoid cyst and is significantly correlated with granulation (p = 0.010, Fisher exact test). Old hemorrhage was found in 13 cases and was significantly correlated with cholesterol crystals. Twenty-one patients were followed up for 1.3–8.6 years after surgery. The 5- and 8-year survival rates were both 100%. Three patients experienced cyst recurrence. The 5- and 8-year recurrence-free rates were 95% and 81.4%, respectively. Conclusions Radiologically, an atypical epidermoid cyst should be differentiated from dermoid cyst, teratoma, schwannoma, glioma, craniopharyngioma, and cavernous angioma. A tendency toward spontaneous hemorrhage is confirmed in atypical epidermoid cysts, and a hypothesis was proposed for spontaneously intracystic hemorrhage in atypical epidermoid cysts. Follow-up confirmed long-term survival of patients with atypical epidermoid cysts.
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- 2012
11. Microneurosurgical management of carotid-ophthalmic aneurysms
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Jie Tang, Yan Zhang, Yuanli Zhao, Wei Lui, Shuo Wang, Dali Sui, and Jizong Zhao
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Adult ,Male ,Microsurgery ,medicine.medical_specialty ,Adolescent ,Neurosurgical Procedures ,Ophthalmic Artery ,Imaging, Three-Dimensional ,Neuroimaging ,Physiology (medical) ,medicine.artery ,Image Processing, Computer-Assisted ,Oculomotor Nerve Diseases ,medicine ,Humans ,Child ,Aged ,Retrospective Studies ,Preoperative planning ,medicine.diagnostic_test ,business.industry ,Mortality rate ,Angiography, Digital Subtraction ,Endoscopy ,Intracranial Aneurysm ,Ultrasonography, Doppler ,General Medicine ,Digital subtraction angiography ,Middle Aged ,Subarachnoid Hemorrhage ,Magnetic Resonance Imaging ,Cerebral Angiography ,Surgery ,Carotid Arteries ,Neurology ,Ophthalmic artery ,Angiography ,Female ,Neurology (clinical) ,Neurosurgery ,Radiology ,Internal carotid artery ,Tomography, X-Ray Computed ,business - Abstract
Objective To evaluate the management of carotid-ophthalmic segment aneurysms (COA) with modern microneurosurgical techniques and instruments. Method Sixty patients with COA undergoing microsurgical clipping between March 1994 and June 2002 in the Department of Neurosurgery, Tiantan Hospital, Beijing, were analyzed retrospectively. Neuroimaging included digital subtraction angiography (DSA), MRI, CT, three-dimensional CT angiography and three-dimensional DSA. From 1998, intraoperative Doppler ultrasound monitoring and endoscope-assisted techniques were used. Result All aneurysms were completely obliterated without either recurrence or death. The morbidity rate of surgery prior to 1998 was 21.7%, which decreased to 13.7% after 1998 (mean 18.3% for the whole study period). Conclusion Preoperative planning based on neuroimaging is very valuable. Advances in neuroimaging, endoscope-assisted techniques and intraoperative Doppler ultrasound monitoring are useful to decrease postoperative complications. Microneurosurgical techniques are optimal for the management of COA with ever lessening morbidity.
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- 2006
12. Co-polysomy of chromosome 1q and 19p predicts worse prognosis in 1p/19q codeleted oligodendroglial tumors: FISH analysis of 148 consecutive cases
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Yong Cui, Dali Sui, Haihui Jiang, Xiangli Cui, Xiaohui Ren, Zhongli Jiang, Jun Ma, and Song Lin
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Oncology ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Pathology ,Oligodendroglioma ,Clinical Investigations ,Context (language use) ,Biology ,Young Adult ,Internal medicine ,Molecular genetics ,medicine ,Humans ,Oligodendroglial Tumor ,In Situ Hybridization, Fluorescence ,Aged ,Polysomy ,medicine.diagnostic_test ,Brain Neoplasms ,Chromosome ,Fish analysis ,Middle Aged ,medicine.disease ,Prognosis ,Chromosomes, Human, Pair 1 ,Female ,Neurology (clinical) ,Chromosome Deletion ,Chromosomes, Human, Pair 19 ,Biomarkers ,Fluorescence in situ hybridization - Abstract
This study aimed to evaluate the prognostic significance of co-polsomy of chromosome 1q and 19p in 1p/19q codeleted oligodendroglial tumors (ODGs).In a series of 148 ODGs with 1p/19q deletion, co-polysomy of 1q and 19p was detected by fluorescence in situ hybridization (FISH). Log-rank analysis and Cox regression methods were used to compare Kaplan-Meier plots and identify factors associated with worse prognosis.There were 104 (70.3%) low-grade ODGs and 44 (29.7%) high-grade ODGs. Co-polysomy was independently associated with shorter progression-free survival and overall survival in 1p/19q codeleted ODGs, irrespective of tumor grades. The odds ratio of without and with co-polysomy was 0.263 (95% confidence interval [CI], 0.089-0.771; P = .015) for progression-free survival and 0.213 (95% CI, 0.060-0.756; P = .017) for overall survival. Subgroup analysis confirmed this trend in both low-grade and high-grade ODGs, although the P value for high-grade ODGs was marginally significant.Co-polysomy of 1q and 19p could be used as a marker to independently predict worse prognoses and guide individual therapy in 1p/19q codeleted ODGs.
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- 2013
13. Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients
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Dali Sui, Xiaohui Ren, Zhongcheng Wang, Song Lin, Zhe Zhang, Xiangli Cui, and Guo-Bin Zhang
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Oncology ,Male ,Cancer Research ,Neurology ,Time Factors ,Loss of Heterozygosity ,Bioinformatics ,Clinical study ,Promoter methylation ,Survivors ,Promoter Regions, Genetic ,DNA Modification Methylases ,In Situ Hybridization, Fluorescence ,Aged, 80 and over ,Brain Neoplasms ,Incidence (epidemiology) ,Middle Aged ,Prognosis ,Isocitrate Dehydrogenase ,Molecular analysis ,Survival Rate ,Chromosomes, Human, Pair 1 ,Female ,Chromosome Deletion ,Adult ,medicine.medical_specialty ,Adolescent ,Real-Time Polymerase Chain Reaction ,Young Adult ,Asian People ,IDH1 Mutation ,Internal medicine ,medicine ,Biomarkers, Tumor ,Humans ,In patient ,Aged ,business.industry ,Tumor Suppressor Proteins ,DNA Methylation ,medicine.disease ,DNA Repair Enzymes ,Mutation ,Neurology (clinical) ,business ,Glioblastoma ,Chromosomes, Human, Pair 19 ,Follow-Up Studies - Abstract
This study was designed to find whether long-term survivors (LTSs) exhibit molecular genetic differences compared with short-term survivors (STSs) in patients with GBM. Tumors from 12 patients initially diagnosed with GBM and survived longer than 36 months (LTSs) were compared with 30 patients with GBM and STSs (survival
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- 2012
14. Intracranial intraparenchymal and intraventricular schwannomas: report of 18 cases
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Siyuan Chen, Hai Liu, Wei Luo, Xiaohui Ren, Song Lin, and Dali Sui
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Brain Edema ,Histogenesis ,Schwannoma ,Neurosurgical Procedures ,Young Adult ,Female patient ,otorhinolaryngologic diseases ,medicine ,Humans ,Central Nervous System Cysts ,Child ,Pathological ,Aged ,business.industry ,Brain Neoplasms ,Cranial nerves ,S100 Proteins ,Cranial Nerves ,Headache ,General Medicine ,Surgical procedures ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,nervous system diseases ,Surgery ,Radiography ,Female ,Neurology (clinical) ,Headaches ,medicine.symptom ,business ,Cerebral Ventricle Neoplasms ,Neurilemmoma ,Male predominance - Abstract
Objective Intracranial schwannomas of the brain, which are unrelated to the cranial nerves, are extremely rare. In this article, we present a series of eighteen cases of intracranial intraparenchymal and intraventricular schwannomas, which is the largest series to date. Methods During the 10-year period from January 2000 to October 2010, we encountered 2491 histologically established cases of intracranial schwannomas, of which only 18 were not related to the cranial nerves. Clinical profiles, radiological features, surgical procedures, intraoperative findings and outcomes were extracted from the patient records and neuroimaging data. Results No patients were preoperatively diagnosed with schwannoma. The diagnosis of schwannoma was made by pathological examination with H&E staining and immunohistochemical examination. The 18 cases with intracranial ectopic schwannomas account for 0.8% of all the intracranial schwannomas that were observed within the same time period at our hospital. The age distribution of the patients ranged from 7 to 78 years. There was a slight male predominance: 11 male and 7 female patients (M:F = 1.6:1). Headaches were the most common presenting symptom and were found in most cases. Common neuroradiological characteristics included peritumoral edema and intralesional cysts. Conclusion Intracranial intraparenchymal and intraventricular schwannomas are rare, benign neoplasms that cannot be preoperatively differentiated from other parenchymal tumors. Surgical excision is curative, and the long-term prognosis is good. Additional studies are needed to confirm the histogenesis of this schwannoma type.
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- 2012
15. Clinical, radiological, and pathological features of 24 atypical intracranial epidermoid cysts
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Xiaohui, Ren, Song, Lin, Zhongcheng, Wang, Lin, Luo, Zhongli, Jiang, Dali, Sui, Zhiyong, Bi, Yong, Cui, Wenqing, Jia, Yan, Zhang, Lanbing, Yu, and Siyuan, Chen
- Subjects
Adult ,Male ,Brain Diseases ,Incidence ,Epidermal Cyst ,Middle Aged ,Magnetic Resonance Imaging ,Diagnosis, Differential ,Radiography ,Young Adult ,Recurrence ,Humans ,Female ,Follow-Up Studies - Abstract
Most intracranial epidermoid cysts typically present with long T1 and T2 signals on MR images. Other epidermoid cysts with atypical MR images are often misdiagnosed as other diseases. In this study the authors aimed to analyze the incidence and the clinical, radiological, and pathological features of atypical epidermoid cysts.Among 428 cases of intracranial epidermoid cysts that were surgically treated between 2002 and 2008 at Beijing Tiantan Hospital, cases with an atypical MR imaging appearance were chosen for analysis. Clinical and pathological parameters were recorded and compared in patients with lesions demonstrating typical and atypical MR appearance.An atypical epidermoid cyst accounts for 5.6% of the whole series. Radiologically, 58.3% of atypical epidermoids were misdiagnosed as other diseases. Compared with a typical epidermoid cyst, atypical epidermoid lesions were significantly larger (p = 0.016, chi-square test). Pathologically, hemorrhage was found in 21 patients with atypical epidermoid cyst and is significantly correlated with granulation (p = 0.010, Fisher exact test). Old hemorrhage was found in 13 cases and was significantly correlated with cholesterol crystals. Twenty-one patients were followed up for 1.3-8.6 years after surgery. The 5- and 8-year survival rates were both 100%. Three patients experienced cyst recurrence. The 5- and 8-year recurrence-free rates were 95% and 81.4%, respectively.Radiologically, an atypical epidermoid cyst should be differentiated from dermoid cyst, teratoma, schwannoma, glioma, craniopharyngioma, and cavernous angioma. A tendency toward spontaneous hemorrhage is confirmed in atypical epidermoid cysts, and a hypothesis was proposed for spontaneously intracystic hemorrhage in atypical epidermoid cysts. Follow-up confirmed long-term survival of patients with atypical epidermoid cysts.
- Published
- 2011
16. Co-deletion of chromosome 1p/19q and IDH1/2 mutation in glioma subsets of brain tumors in Chinese patients
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Xiangli Cui, Jing Li, Song Lin, Zhongcheng Wang, Zhongli Jiang, Junmei Wang, Dali Sui, and Xiaohui Ren
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Adult ,Pathology ,medicine.medical_specialty ,IDH1 ,Adolescent ,Brain tumor ,lcsh:Medicine ,Bioinformatics ,Diagnostic Radiology ,Asian People ,Diagnostic Medicine ,Glioma ,medicine ,Humans ,Oligodendroglial Tumor ,lcsh:Science ,Pathological ,Neurological Tumors ,Genetic Association Studies ,In Situ Hybridization, Fluorescence ,Aged ,DNA Primers ,Multidisciplinary ,business.industry ,Brain Neoplasms ,lcsh:R ,Astrocytoma ,Cancers and Neoplasms ,Sequence Analysis, DNA ,Middle Aged ,medicine.disease ,Isocitrate Dehydrogenase ,Oncology ,Chromosomes, Human, Pair 1 ,Mutation (genetic algorithm) ,Mutation ,Medicine ,lcsh:Q ,Oligodendroglioma ,Chromosome Deletion ,business ,Radiology ,Research Article - Abstract
Objective To characterize co-deletion of chromosome 1p/19q and IDH1/2 mutation in Chinese brain tumor patients and to assess their associations with clinical features. Methods In a series of 528 patients with gliomas, pathological and radiological materials were reviewed. Pathological constituents of tumor subsets, incidences of 1p/19q co-deletion and IDH1/2 mutation in gliomas by regions and sides in the brain were analyzed. Results Overall, 1p and 19q was detected in 339 patients by FISH method while the sequence of IDH1/2 was determined in 280 patients. Gliomas of frontal, temporal and insular origin had significantly different pathological constituents of tumor subsets (P
- Published
- 2011
17. Primary central nervous system histiocytic sarcoma mimicking glioma
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Jiwei Bai, Guang Li, Song Lin, Dali Sui, and Mi Shen
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Pathology ,medicine.medical_specialty ,Primary (chemistry) ,medicine.diagnostic_test ,business.industry ,Central nervous system ,Magnetic resonance imaging ,Histiocytic sarcoma ,medicine.disease ,medicine.anatomical_structure ,Neurology ,Glioma ,medicine ,Neurology (clinical) ,business - Published
- 2014
18. Clinical, radiological, and pathological features of 24 atypical intracranial epidermoid cysts.
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XIAOHUI REN, SONG LIN, ZHONGCHENG WANG, LIN LUO, ZHONGLI JIANG, DALI SUI, ZHIYONG BI, YONG CUI, WENQING JIA, YAN ZHANG, LANHING YU, and SIYUAN CHEN
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- 2012
- Full Text
- View/download PDF
19. Intracranial intraparenchymal and intraventricular schwannomas: Report of 18 cases.
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Wei Luo, Xiaohui Ren, Siyuan Chen, Hai Liu, Dali Sui, and Song Lin
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CRANIAL nerves , *BRAIN imaging , *IMMUNOHISTOCHEMISTRY , *SURGICAL excision , *TUMORS - Abstract
Objective: Intracranial schwannomas of the brain, which are unrelated to the cranial nerves, are extremely rare. In this article, we present a series of eighteen cases of intracranial intraparenchymal and intraventricular schwannomas, which is the largest series to date. Methods: During the 10-year period from January 2000 to October 2010, we encountered 2491 histologically established cases of intracranial schwannomas, of which only 18 were not related to the cranial nerves. Clinical profiles, radiological features, surgical procedures, intraoperative findings and outcomes were extracted from the patient records and neuroimaging data. Results: No patients were preoperatively diagnosed with schwannoma. The diagnosis of schwannoma was made by pathological examination with H&E staining and immunohistochemical examination. The 18 cases with intracranial ectopic schwannomas account for 0.8% of all the intracranial schwannomas that were observed within the same time period at our hospital. The age distribution of the patients ranged from 7 to 78 years. There was a slight male predominance: 11 male and 7 female patients (M:F = 1.6:1). Headaches were the most common presenting symptom and were found in most cases. Common neuroradiological characteristics included peritumoral edema and intralesional cysts. Conclusion: Intracranial intraparenchymal and intraventricular schwannomas are rare, benign neoplasms that cannot be preoperatively differentiated from other parenchymal tumors. Surgical excision is curative, and the long-term prognosis is good. Additional studies are needed to confirm the histogenesis of this schwannoma type. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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