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2. P1446: PHASE I STUDY DATA UPDATE OF PHE885, A FULLY HUMAN BCMA-DIRECTED CAR-T CELL THERAPY MANUFACTURED USING THE T-CHARGETM PLATFORM FOR PATIENTS WITH RELAPSED/REFRACTORY (R/R) MULTIPLE MYELOMA (MM)

Author

Sperling, A. S., primary, Nikiforow, S., additional, Derman, B., additional, Nadeem, O., additional, Mo, C., additional, Laubach, J., additional, Anderson, K., additional, Alonso, A., additional, Im, S.-Y., additional, Ikwgawa, S., additional, Prabhala, R., additional, Hernandez Rodriduez, D., additional, Daley, H., additional, Shaw, K. L., additional, Arihara, Y., additional, Ansari, S., additional, Quinn, D. S., additional, Pearson, D., additional, Hack, A., additional, Treanor, L., additional, Bu, D., additional, Mataraza, J., additional, Rispoli, L., additional, Credi, M., additional, Ritz, J., additional, Jakubowiak, A., additional, De Vita, S., additional, and Munshi, N., additional

Published
2022
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10. Safety considerations in the generation of clinical grade autologous ips cell lines

Author

Anderson, H., primary, Daheron, L., additional, Savvidis, G., additional, Negre, H., additional, Nag, A., additional, Thorner, A., additional, Liu, X., additional, Gu, S., additional, Hu, X., additional, Kelley, M., additional, Chow, S., additional, Daley, H., additional, Manduke, R., additional, Hwa, A., additional, Pagliuca, F., additional, and Ritz, J., additional

Published
2018
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16. A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantation

Author

Nikiforow, S., primary, Kim, H. T., additional, Daley, H., additional, Reynolds, C., additional, Jones, K. T., additional, Armand, P., additional, Ho, V. T., additional, Alyea, E. P., additional, Cutler, C. S., additional, Ritz, J., additional, Antin, J. H., additional, Soiffer, R. J., additional, and Koreth, J., additional

Published
2016
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20. The impact of HIV infection on the clinical presentation of severe malnutrition in children at QECH

Author

Kessler, L, Daley, H, Malenga, G, and Graham, SM

Abstract

A study was undertaken in a central nutritional rehabilitation unit (NRU) in southern Malawi to assess the impact of HIV infection on clinical presentation and case fatality rate. The HIV seroprevalence for 250 severely malnourished children over 1 year of age was 34.4% and the overall mortality was 28%. HIV infection was significantly more associated with marasmus (62.2%) than with kwashiorkor (21.7%) [p

Published
2001

21. Act now against new NHS competition regulations

Author

Davis, J., primary, Banks, I., additional, Wrigley, D., additional, Peedell, C., additional, Pollock, A., additional, McPherson, K., additional, McKee, M., additional, Irving, W. L., additional, Crome, P., additional, Greenhalgh, T., additional, Holland, W., additional, Evans, D., additional, Maryon-Davis, A., additional, Smyth, A., additional, Fleming, P., additional, Coleman, M., additional, Sharp, D. J., additional, Whincup, P., additional, Logan, S., additional, Cook, D., additional, Moore, R., additional, Rawaf, S., additional, McEewen, J., additional, West, R., additional, Yudkin, J. S., additional, Clarke, A., additional, Finer, N., additional, Domizio, P., additional, Bambra, C., additional, Jones, A., additional, Feder, G., additional, Scott-Samuel, A., additional, Irvine, L., additional, Sharma, A., additional, Fitchett, M., additional, Boomla, K., additional, Folb, J., additional, Paul, A., additional, McCoy, D., additional, Tallis, R., additional, Burgess-Allen, J., additional, Edwards, M., additional, Tomlinson, J., additional, Colvin, D., additional, Gore, J., additional, Brown, K., additional, Mitchel, S., additional, Lau, A., additional, Sayer, M., additional, Clark, L., additional, Silverman, R., additional, Marmot, S., additional, Rainbow, D., additional, Carter, L., additional, Mann, N., additional, Fielding, R., additional, Logan, J., additional, Tebboth, L., additional, Arnold, N., additional, Stobbart, K., additional, Cabot, K., additional, Finer, S., additional, Davies, D., additional, Buttivant, H., additional, Kraemer, S., additional, Newell, J., additional, Griffiths, A., additional, FitzGerald, R., additional, MacGibbon, R., additional, Lee, A., additional, Macklon, A. F., additional, Hobson, E., additional, Jenner, D., additional, Jacobson, B., additional, Timmis, A., additional, Salim, A., additional, Evans-Jones, J., additional, Caan, W., additional, Awsare, N., additional, Pride, N., additional, Suckling, R., additional, Bratty, C., additional, Rossiter, B., additional, Hawkins, D., additional, Currie, J., additional, Camilleri-Ferrante, C., additional, Fluxman, J., additional, Bhatti, O., additional, Anson, J., additional, Etherington, R., additional, Lawrence, D., additional, Fell, H., additional, Clarke, E., additional, Ormerod, J., additional, Ormerod, O., additional, Ireland, M., additional, Duncan, J. A. T., additional, Chandy, R., additional, Mindell, J., additional, Mullen, P., additional, Bennett-Richards, P., additional, Hirst, J., additional, Murphy, E., additional, Martin, P., additional, Lowes, S., additional, Grunewald, R., additional, Reeve, J., additional, Schweiger, M., additional, Coates, J., additional, Farrelly, G., additional, Chamberlain, M. A., additional, Lewis, G., additional, Young, J., additional, Scott, B., additional, Gibbs, J., additional, Landers, A., additional, Deveson, P., additional, Ingrams, G., additional, Leigh, M., additional, Gawler, J., additional, Ford, A., additional, Nixon, J., additional, McCartney, M., additional, Bareford, D., additional, Singh, S., additional, Lockwood, K., additional, Cripwell, M., additional, Ehrhardt, P., additional, Bell, D., additional, Wortley, P., additional, Tomlinson, L., additional, Hotchkiss, J., additional, Ford, S., additional, Turner, G., additional, Reissman, G., additional, Lewis, D., additional, Johnstone, C., additional, Tomson, M., additional, Torabi, P., additional, Tomson, D., additional, Tulloch, A., additional, Johnston, S., additional, Dickinson, J., additional, McElderry, E., additional, Ross, W., additional, Holt, K., additional, Logan, M., additional, Klonin, H., additional, Danby, J., additional, Goodger, V., additional, Puntis, J., additional, Dickson, H., additional, Gould, D. A., additional, Livingstone, A., additional, Lefevre, D., additional, Kendall, B., additional, Singh, G., additional, Hall, P., additional, Darling, J., additional, Hamlyn, A. N., additional, Patel, A., additional, Erskine, J., additional, Fisher, B., additional, Hughes, R., additional, Highton, C., additional, Venning, H., additional, Singer, R., additional, Brearey, S., additional, Sikorski, J., additional, Paintin, D., additional, Feehally, J., additional, Savage, W., additional, Freud, K. M., additional, Holt, V. J., additional, Gill, A., additional, Waterston, T., additional, Souza, R. d., additional, Hopkinson, N., additional, Beadsworth, M., additional, Franks, A., additional, Daley, H., additional, Cullinan, P., additional, Basarab, A., additional, Gurling, H., additional, Zinkin, P., additional, Kirwin, S., additional, Buhrs, E., additional, Brown, R., additional, West, A., additional, Marlowe, G., additional, Fellows, G., additional, Main, J., additional, Applebee, J., additional, Koperski, M., additional, Jones, P., additional, Macfarlane, A., additional, Beer, N., additional, Mason, R., additional, Eisner, M., additional, Smailes, A., additional, Timms, P., additional, Knight, D., additional, Jones, C., additional, Wesby, B., additional, Lyttelton, L., additional, Morrison, R., additional, Bossano, D., additional, Walker, J., additional, Davies, G., additional, Godfrey, P., additional, Wolfe, I., additional, Nsutebu, E., additional, Stevenson, N., additional, Cheeroth, S., additional, Miller, J., additional, Johnson, G., additional, Noor, R., additional, Hall, A., additional, Bostock, D., additional, Michael, B., additional, Sharvill, J., additional, Macpherson, J., additional, Ma, R., additional, Middleton,, J., additional, Jeffreys, A., additional, Cole, J., additional, Boswell, J. P., additional, Bury, B., additional, Mitchison, S., additional, Kinmonth, A.-L., additional, Young, G., additional, Maclennan, I., additional, and Munday, P., additional

Published
2013
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22. Right of Way.

Author

Daley, H. S.

Subjects
RIGHT of way, FREEDOM of association
Published
2022

26. Experimental study of colloid annular thrusters

Author

Daley, H. L, Mahoney, J. F, Perel, J, Sherman, A, and Yahiku, A. Y

Subjects
Propulsion Systems
Abstract

Colloid annular thrustors performance tests in vacuum chamber with LN cooled liner, using high speed analog to digital system to acquire time of flight /TOF/ data

Published
1970

29. Cesium ion sputtering of aluminum, copper, and titanium.

Author

Daley, H. L and Perel, J

Subjects
Physics, Solid-State
Abstract

Sputtering yields of aluminum, copper and titanium measured as function of cesium ion energies for use as electrodes on cesium ion engines

Published
1967

30. Cesium ion sputtering of aluminum, copper, and titanium.

Author

Daley, H. L and Perel, J

Subjects
Physics, Solid-State
Abstract

Sputtering yields of aluminum, copper and titanium measured as function of cesium ion energies for use as electrodes on cesium ion engines

Published
1966

31. Duration test of an annular colloid thruster.

Author

Perel, J, Mahoney, J. F, and Daley, H. L

Subjects
Propulsion Systems
Abstract

An annular colloid thruster was continuously operated for 1023 hours. Performance was stable with no sparking and negligible drain currents observed. An average thrust of 25.1 micropounds and an average specific impulse of 1160 seconds were obtained at an accelerating voltage of 15 k he thruster exhaust beam was continuously neutralized using electrons and electrostatic vectoring was demonstrated periodically. The only clear trend with time was an increase in specific impulse during the last third of the test period. From these results the thruster lifetime was estimated to be over an order of magnitude greater than the test duration.

Published
1972

35. CD34 + CD38 - and CD34 +   HLA-DR - cells in BM stem cell grafts correlate with short-term engraftment but have no influence on long-term hematopoietic reconstitution after autologous transplantation.

Author

Zubair, AC, Kao, G, Daley, H, Schott, D, Freedman, A, and Ritz, J

Subjects
LEUKEMIA, LYMPHOMAS, HEMATOPOIETIC stem cell transplantation, PHENOTYPES, CRYOPRESERVATION of organs, tissues, etc.
Abstract

Background Prior studies have demonstrated that relatively immature hematopoietic stem cells, including CD34 + CD38 - and CD34 +   HLA-DR - subsets, correlate with short-term hematopoietic reconstruction (SHR) after transplantation. The aim of this study was to investigate whether these immature CD34 + subsets also correlate with long-term hematopoietic reconstitution (LHR) in recipients of ABMT. Methods We examined stem cell grafts from 58 patients with B-cell lymphoma or CLL who underwent ABMT after myeloablative conditioning. We determined whether total mononuclear cell dose (MNC), colony-forming unit–granulocyte-monocyte (CFU-GM), CD34 + cell dose and CD34 + cell subsets (CD34 +   CD38 - and CD34 +   HLA-DR - ) were associated with SHR and/or LHR. Time to neutrophil engraftment (TNE) and time to platelet engraftment (TPE) were used to measure SHR, while platelet counts at day 100 and 1 year post-ABMT were used as indicators for LHR. Results and discussion CD34 + cell dose and CD34 + cell subsets were significantly associated with SHR. However, at day 100 and 1 year post-transplant only total CD34 + cell dose was associated with LHR. The association of total CD34 + cell dose with LHR persisted after adjusting for age, sex and disease. None of the CD34 + cell subsets analyzed showed evidence of significant association with LHR. [ABSTRACT FROM AUTHOR]

Published
2006
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36. Partial CD8+T-cell depletion of allogeneic peripheral blood stem cell transplantation is insufficient to prevent graft-versus-host disease.

Author

Ho, V. T., Kim, H. T., Li, S., Hochberg, E. P., Cutler, C., Lee, S. J., Fisher, D. C., Milford, E., Kao, G., Daley, H., Levin, J., Ng, A., Mauch, P., Alyea, E. P., Antin, J. H., and Soiffer, R. J.

Subjects
STEM cell transplantation, BONE marrow transplantation, BONE marrow, HOMOGRAFTS, LYMPHOCYTE transformation, TRANSPLANTATION of organs, tissues, etc.
Abstract

Summary:Prior studies suggest that depletion of CD8+T cells from donor bone marrow or donor lymphocyte infusions can reduce graft-versus-host disease (GVHD) without compromising graft-versus-leukemia. We explored CD8 depletion in patients undergoing matched related donor (MRD, n=25) and unrelated donor (URD, n=16) peripheral blood stem cell transplantation following myeloablative conditioning with cyclophosphamide (60?mg/kg/day i.v.×2) and total body irradiation (200?cGy×7 fractions). Ex vivo incubation of mobilized donor peripheral blood cells with anti-CD8 antibody coated high-density microparticles removed 99%of CD8+cells. The median number of CD8+cells infused was 3.9×105 cells/kg (2.2×105 in MRD, and 8.1×105 in URD patients). Post transplant immune suppression included tacrolimus in the MRD cohort, and tacrolimus plus mini-methotrexate (5?mg/m2 days+1, 3, 6, 11) in the URD cohort. All 41 patients engrafted. Grade 2-4 acute GVHD incidence was 61%(44%MRD, 88%URD). Chronic GVHD incidence was 50%(48%MRD, 55%URD). Relapse incidence was 4.9%. Estimated event-free and overall survival rates were 65 and 63%, respectively, at 1 year and 56 and 57%, respectively, at 2 years. There was no correlation between CD8+number and GVHD or survival. A 2-log depletion of CD8+cells from PBSC is insufficient to prevent GVHD.Bone Marrow Transplantation (2004) 34, 987-994. doi:10.1038/sj.bmt.1704690 Published online 18 October 2004 [ABSTRACT FROM AUTHOR]

Published
2004
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39. Hematologic engraftment and immune reconstitution posttransplantation with anti-B1 purged autologous bone marrow

Author

Anderson, KC, Ritz, J, Takvorian, T, Coral, F, Daley, H, Gorgone, BC, Freedman, AS, Canellos, GP, Schlossman, SF, and Nadler, LM

Abstract

Hematologic engraftment and immune reconstitution were examined in patients who received cyclophosphamide and total body irradiation therapy followed by infusion of autologous bone marrow purged with anti- B1 monoclonal antibody (MoAb) and complement as therapy for non- Hodgkin's lymphoma. Hematologic engraftment was prompt with return of greater than or equal to 0.5 X 10(3)/microL granulocytes and greater than or equal to 2 X 10(4)/microL platelets at a median of 26 and 29 days posttransplant, respectively. Immunologic reconstitution, in contrast, was prolonged. Normal numbers of circulating B cells were consistently noted by five months posttransplant, whereas return of normal immunoglobulin levels in some patients did not occur for one year. Normal numbers of T cells were evident within the first month posttransplant, but a reversed T4:T8 ratio persisted in some patients up to three years. In vitro responses of either B cells to triggers of activation or of T cells to mitogens and antigens were not normal for at least three months posttransplant. Natural killer (NK) cells predominated early after transplant and may demonstrate cytotoxicity against tumor cells. Our studies demonstrate that transplantation with anti-B1 purged autologous bone marrow results in complete hematologic and delayed immunologic engraftment. No significant acute or chronic clinical toxicities have been observed.

Published
1987
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