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We propose a hardware-optimized design that implements a Montgomery Elliptic-curve point multiplication Algorithm over $GF(2^{233})$ using Lopez-Dahab projective coordinates. Moreover, we propose a digit-parallel modular multiplier, which reduces clock cycles and improves throughput. Also, we provided how to use our proposed digit-parallel multiplier for post-quantum cryptography algorithms. In addition, we use the proposed digit-parallel multiplier with the square circuit to implement the Itoh-Tsujii inversion algorithm for modular inversion computation; this permits hardware resource minimization. An efficient finite-state machine controller is implemented for control functionalities. A figure of merit in throughput/area is defined for reasonable comparison to state-of-the-art. We provide implementation results after post-place-and-route on field-programmable gate array devices. On the Virtex-7 device, our design utilizes 3386 slices and requires 7218 clock cycles; it achieves a maximum frequency of 365 MHz and computes one point multiplication in $19.77\mu s$ . The total power consumption of our design is 2027 mW. The calculated values for throughput and figure of merit are 50.58Kbps and 14.93, respectively. Consequently, the implementation results and comparisons reveal our design’s suitability for applications requiring area and throughput-optimized cryptographic implementations.

This paper analyzes the system describing the absorption solar collector as an application of nanoparticles for the storage of solar energy. The system involves two fractional partial differential equations (FPDEs) utilizing the Caputo fractional definition (CFD). Explicit solutions are determined for the temperature and velocity in terms of the Wright function (WrFn) via Laplace transform (LT). In addition, the solutions are expressed in terms of some well–known special functions at selected values of the fractional–order. Moreover, the behaviors of the temperature and velocity are investigated graphically using the thermo–physical data of the Cu/Al2O3–nanoparticles. Furthermore, some numerical results are conducted about the performance of the Cu and Al2O3. The results reveal the higher efficiency/performance of the Cu–nanoparticles over the Al2O3 and thus copper enjoys higher capability than alumina for the purpose of solar energy storage. In addition, it is found that 1.41% in the enhancement of heat transfer is achieved by adding 1% of the Cu–nanoparticles while the corresponding enhancement rate of the other three nanoparticles was less. Besides, the enhancement rate reaches 7.1% by increasing the volume fraction of the Cu–nanoparticles to 5%. Furthermore, the enhancement rates for the TiO2, Ag, and Al2O3 are 5.41%, 6.47%, and 6.53%, respectively when using 5% of these nanoparticles. Finally, the advantages/effectiveness of the current approach over a previous work in the literature are discussed in detail.

Smitha Hosahalli Vasanna, Maria A Pereda, Jignesh Dalal Department of Pediatrics, Division of Pediatric Hematology Oncology, Rainbow Babies and Children’s Hospital, University Hospitals, Cleveland, OH, USACorrespondence: Jignesh DalalDepartment of Pediatrics, Division of Pediatric Hematology Oncology, Rainbow Babies and Children’s Hospital, University Hospitals, 11100 Euclid Ave, Cleveland, OH, 44106, USATel +1 2169831027Fax +1 2168445431Email jignesh.dalal@uhhospitals.orgAbstract: Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive inborn error of immunity (IEI) first described in 1937. Classic WAS is characterized by the triad of thrombocytopenia with small platelets, recurrent infections due to combined immunodeficiency, and eczema. Hematopoietic stem cell transplantation (HSCT) was the only curative option available for five decades, with excellent outcomes reported for matched sibling donors (MSD) and matched unrelated donors (MUD). More recently, alternative donor transplants such as umbilical cord blood (UCB) and haploidentical transplant have emerged as viable options due to improvements in better graft selection, cell dosing, and effective allograft manipulation measures. Gene therapy is another potential curative option with promising results, yet currently is offered only as part of a clinical trial.Keywords: Wiskott–Aldrich syndrome, X-linked thrombocytopenia, supportive care, hematopoietic stem cell transplantation, gene therapy

This paper proposes a novel hardware design for a compact crypto processor devoted to elliptic-curve point multiplication over GF(2233). We focus on minimizing hardware usage, which we obtain using an iterative bit–serial finite field modular multiplier for polynomial coefficient multiplication. The same multiplier is also used for modular squares and inversion computations, further optimizing the hardware footprint. Our design offers flexibility by permitting users to load different curve parameters and secret keys while keeping a low-area hardware design. To efficiently generate the control signals, we utilize a finite-state-machine-based controller. We have implemented the proposed crypto processor on Virtex-6 and Virtex-7 FPGA devices, and we have evaluated its performance at clock frequencies of 100, 50, and 10 MHz. Specifically, for one point multiplication computation on Virtex-7 FPGA, our crypto processor uses 391 slices, attains a maximum frequency of 161 MHz, has a latency of 4.45 ms, and consumes 77 mW of power. These results, along with a comparison to state-of-the-art designs, clearly demonstrate the practicality of our crypto processor for applications requiring efficient and compact cryptographic computations.

استخلاص المعالم من السطوح الطبوغرافية هي إنشاء صورة نقطية تمثل ارتفاعات سطح الأرض بالاعتماد على نموذج الارتفاع الرقمي الذي يعتبر الأساس الذي يعتمد عليه تحليل السطوح الطبوغرافية . إن نماذج الارتفاعات الرقمية تستنبط بشكل رئيسي بتطبيق النماذج المجسمة ( زوج من الصور) المتوفرة من المسح التصويري وبيانات التحسس النائي أو من الخرائط الطبوغرافية وهنا تم استخدام نموذج ارتفاع رقمي مستخلص من الخرائط الطبوغرافية ، واشتقاق عدد من الخصائص الهامة من نموذج الارتفاع الرقمي مثل إصدار 9.3 ، والتي تعتبر مدخلات ArcGIS الانحدار والتوجيه وظلال الأرض باستخدام برنامج لاستخلاص الخصائص الهيدرولوجية مثل تحديد اتجاه سريان المياه فوق سطح الأرض بعدها تم حساب تراكم لتحديد Basin لتحديد الوديان الموجودة في المنطقة وإنتاج خارطة Stream order السريان و إنتاج خارطة إصدار 9.3 ArcGIS حوض التغذية وبالاعتماد على هذه الطبقات يتم اختيار مواقع للسدود باستخدام برنامج .Arc Hydro وامتداده

BACKGROUND: Evidence about the impact of marital status before hematopoietic cell transplantation (hct) on outcomes after hct is conflicting. METHODS: We identified patients 40 years of age and older within the Center for International Blood and Marrow Transplant Research registry who underwent hct between January 2008 and December 2015. Marital status before hct was declared as one of: married or living with a partner, single (never married), separated or divorced, and widowed. We performed a multivariable analysis to determine the association of marital status with outcomes after hct. RESULTS: We identified 10,226 allogeneic and 5714 autologous hct cases with, respectively, a median follow-up of 37 months (range: 1-102 months) and 40 months (range: 1-106 months). No association between marital status and overall survival was observed in either the allogeneic (p = 0.58) or autologous (p = 0.17) setting. However, marital status was associated with grades 2-4 acute graft-versus-host disease (gvhd), p < 0.001, and chronic gvhd, p = 0.04. The risk of grades 2-4 acute gvhd was increased in separated compared with married patients [hazard ratio (hr): 1.13; 95% confidence interval (ci): 1.03 to 1.24], and single patients had a reduced risk of grades 2-4 acute gvhd (hr: 0.87; 95% ci: 0.77 to 0.98). The risk of chronic gvhd was lower in widowed compared with married patients (hr: 0.82; 95% ci: 0.67 to 0.99). CONCLUSIONS: Overall survival after hct is not influenced by marital status, but associations were evident between marital status and grades 2-4 acute and chronic gvhd. To better appreciate the effects of marital status and social support, future research should consider using validated scales to measure social support and patient and caregiver reports of caregiver commitment, and to assess health-related quality of life together with health care utilization.

Separating hydroalcoholic mixtures remains a significant challenge in engineering. Liquid–liquid extraction has emerged as an appealing alternative method, because it avoids the need for the large energy inputs, volatile organic compounds, and high pressures that are typically required by other separation processes. This study explores the use of hydrophobic deep eutectic solvents (HDESs) composed of terpenes and 10-undecenoic acid as extraction agents for the liquid–liquid separation of hydroalcoholic mixtures composed of alcohols (ethanol, propan-1-ol, and propan-2-ol) and water. The water content in the solvents studied was notably low, reflecting their hydrophobic nature. For the dried HDES samples, the water content ranged from 553 to 4901 ppm. In contrast, the water-saturated samples exhibited higher water contents, ranging from 7250 to 20,864 ppm. The HDES based on thymol, DL-menthol, and L-menthol displayed a eutectic point at an xterpenes of approximately 0.67. These mixtures maintained a liquid state up to a mole fraction of terpenes around 0.75. In contrast, the HDES composed of carvacrol, fenchyl alcohol, and α-terpineol exhibited their eutectic point at an xterpenes near 0.5. Notably, these mixtures remained in a liquid state across the entire composition range studied. The 2:1 molar ratio (HBA:HBD) presented the best values for extracting alcohols, reaching 34.04%, 36.59%, and 39.78% for ethanol, propan-2-ol, and propan-1-ol, respectively. These results show that HDES can be applied to overcome issues with existing extraction solvents, increasing the separation efficiency and making the process eco-friendly. [ABSTRACT FROM AUTHOR]

This paper proposes a novel hardware design for a compact crypto processor devoted to elliptic-curve point multiplication over G F (2 233) . We focus on minimizing hardware usage, which we obtain using an iterative bit–serial finite field modular multiplier for polynomial coefficient multiplication. The same multiplier is also used for modular squares and inversion computations, further optimizing the hardware footprint. Our design offers flexibility by permitting users to load different curve parameters and secret keys while keeping a low-area hardware design. To efficiently generate the control signals, we utilize a finite-state-machine-based controller. We have implemented the proposed crypto processor on Virtex-6 and Virtex-7 FPGA devices, and we have evaluated its performance at clock frequencies of 100, 50, and 10 MHz. Specifically, for one point multiplication computation on Virtex-7 FPGA, our crypto processor uses 391 slices, attains a maximum frequency of 161 MHz, has a latency of 4.45 ms, and consumes 77 mW of power. These results, along with a comparison to state-of-the-art designs, clearly demonstrate the practicality of our crypto processor for applications requiring efficient and compact cryptographic computations. [ABSTRACT FROM AUTHOR]