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232 results on '"Dal Bello, Federica"'

10. Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model

Author

Aimaretti, Eleonora, primary, Porchietto, Elisa, additional, Mantegazza, Giacomo, additional, Gargari, Giorgio, additional, Collotta, Debora, additional, Einaudi, Giacomo, additional, Ferreira Alves, Gustavo, additional, Marzani, Enrica, additional, Algeri, Alessandro, additional, Dal Bello, Federica, additional, Aragno, Manuela, additional, Cifani, Carlo, additional, Guglielmetti, Simone, additional, Mastrocola, Raffaella, additional, and Collino, Massimo, additional

Published
2024
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12. Dietary Intake of Fructooligosaccharides Protects against Metabolic Derangements Evoked by Chronic Exposure to Fructose or Galactose in Rats

Author

Almasri, Fidèle, primary, Collotta, Debora, additional, Aimaretti, Eleonora, additional, Sus, Nadine, additional, Aragno, Manuela, additional, Dal Bello, Federica, additional, Eva, Carola, additional, Mastrocola, Raffaella, additional, Landberg, Rikard, additional, Frank, Jan, additional, and Collino, Massimo, additional

Published
2023
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13. Formation of by-products during chemical interesterification of lipids. Detection and characterization of dialkyl ketones by non-aqueous reversed-phase liquid chromatography-high resolution mass spectrometry and gas chromatography-mass spectrometry

Author

Santoro, Valentina, Baiocchi, Claudio, Dal Bello, Federica, Gastaldi, Daniela, Aigotti, Riccardo, Zorzi, Michael, Pellegrino, Andrea, Forte, Emanuele, Romaniello, Francesco, Magni, Martina, Fontana, Mauro, Somenzi, Marco, and Medana, Claudio

Published
2018
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16. High-Throughput Microscopy Analysis of Mitochondrial Membrane Potential in 2D and 3D Models

Author

Vianello, Caterina, primary, Dal Bello, Federica, additional, Shin, Sang Hun, additional, Schiavon, Sara, additional, Bean, Camilla, additional, Magalhães Rebelo, Ana Paula, additional, Knedlík, Tomáš, additional, Esfahani, Emad Norouzi, additional, Costiniti, Veronica, additional, Lacruz, Rodrigo S., additional, Covello, Giuseppina, additional, Munari, Fabio, additional, Scolaro, Tommaso, additional, Viola, Antonella, additional, Rampazzo, Elena, additional, Persano, Luca, additional, Zumerle, Sara, additional, Scorrano, Luca, additional, Gianelle, Alessio, additional, and Giacomello, Marta, additional

Published
2023
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17. Different Effects of High-Fat/High-Sucrose and High-Fructose Diets on Advanced Glycation End-Product Accumulation and on Mitochondrial Involvement in Heart and Skeletal Muscle in Mice.

Author

Aimaretti, Eleonora, Chimienti, Guglielmina, Rubeo, Chiara, Di Lorenzo, Rosa, Trisolini, Lucia, Dal Bello, Federica, Moradi, Atefeh, Collino, Massimo, Lezza, Angela Maria Serena, Aragno, Manuela, and Pesce, Vito

Abstract

Diets with an elevated content of fat, sucrose, or fructose are recognized models of diet-induced metabolic alterations, since they induce metabolic derangements, oxidative stress, and chronic low-grade inflammation associated with local and systemic accumulation of advanced glycation end-products (AGEs). This study used four-week-old C57BL/6 male mice, randomly assigned to three experimental dietary regimens: standard diet (SD), high-fat high-sucrose diet (HFHS), or high fructose diet (HFr), administered for 12 weeks. Plasma, heart, and tibialis anterior (TA) skeletal muscle were assayed for markers of metabolic conditions, inflammation, presence of AGEs, and mitochondrial involvement. The HFHS diet induced a tissue-specific differential response featuring (1) a remarkable adaptation of the heart to HFHS-induced heavy oxidative stress, demonstrated by an increased presence of AGEs and reduced mitochondrial biogenesis, and efficaciously counteracted by a conspicuous increase in mitochondrial fission and PRXIII expression; (2) the absence of TA adaptation to HFHS, revealed by a heavy reduction in mitochondrial biogenesis, not counteracted by an increase in fission and PRXIII expression. HFr-induced mild oxidative stress elicited tissue-specific responses, featuring (1) a decrease in mitochondrial biogenesis in the heart, likely counteracted by a tendency for increased fission and (2) a mild reduction in mitochondrial biogenesis in TA, likely counteracted by a tendency for increased fusion, showing the adaptability of both tissues to the diet. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

Author

Campa, Carlo C., Silva, Rangel L., Margaria, Jean P., Pirali, Tracey, Mattos, Matheus S., Kraemer, Lucas R., Reis, Diego C., Grosa, Giorgio, Copperi, Francesca, Dalmarco, Eduardo M., Lima-Júnior, Roberto C. P., Aprile, Silvio, Sala, Valentina, Dal Bello, Federica, Prado, Douglas Silva, Alves-Filho, Jose Carlos, Medana, Claudio, Cassali, Geovanni D., Tron, Gian Cesare, Teixeira, Mauro M., Ciraolo, Elisa, Russo, Remo C., and Hirsch, Emilio

Published
2018
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22. Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of the Liver, Promoting Hepatic Oxidative and Glycative Stress

Author

Mastrocola, Raffaella, primary, Aimaretti, Eleonora, additional, Ferreira Alves, Gustavo, additional, Cento, Alessia Sofia, additional, Fornelli, Claudia, additional, Dal Bello, Federica, additional, Ferraris, Chiara, additional, Goitre, Luca, additional, Perrelli, Andrea, additional, and Retta, Saverio Francesco, additional

Published
2022
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26. Advanced glycation end products and their related signaling cascades in adult survivors of childhood Hodgkin lymphoma: A possible role in the onset of late complications

Author

Felicetti, Francesco, primary, Aimaretti, Eleonora, additional, Dal Bello, Federica, additional, Gatti, Filippo, additional, Godono, Alessandro, additional, Saba, Francesca, additional, Einaudi, Giacomo, additional, Collino, Massimo, additional, Fagioli, Franca, additional, Aragno, Manuela, additional, and Brignardello, Enrico, additional

Published
2022
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29. Study of the photoinduced transformations of maprotiline in river water using liquid chromatography high-resolution mass spectrometry

Author

Goncalves, Nuno P. F. Varga, Zsuzsanna Bouchonnet, Stephane and Dulio, Valeria Alygizakis, Nikiforos Dal Bello, Federica and Medana, Claudio Calza, Paola

Abstract

Maprotiline was identified as a compound of potential interest further to a suspect screening test carried out for a list of more than 40,000 substances based on specific occurrence, hazard and risk indicators. Despite the high frequency of appearance of this drug in wastewater treatment stations, his environmental fate is still unknown. Herein, we investigated for the first time the maprotiline degradation pathways in river water spiked with the drug at a concentration close to those detected in natural waters. Preliminary photocatalytic experiments in ultrapure water produced 32 transformation products (TPs) resulted mainly from the multiple hydroxylation/oxidation in different positions of the drug molecule. From the river water experiments, 12 TPs were formed by photolysis matching with those observed in ultrapure water experiments, and 2 were also formed resulted from biotic degradation. Employing HPLC-HRMS, we were able to elucidate the chemical structures of TPs and assess the overall degradation mechanism. Preliminary bioassays suggested lower toxicity of TPs relatively to the parent compound. (c) 2020 The Authors. Published by Elsevier B.V.

Published
2021

30. GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton 2021.03.04.433895

Author

Wolf, Christina, Pouya, Alireza, Bitar, Sara, Pfeiffer, Annika, Bueno, Diones, Arndt, Sabine, Tenzer, Stefan, Dal Bello, Federica, Vianello, Caterina, Ritz, Sandra, Schwirz, Jonas, Dobrindt, Kristina, Peitz, Michael, Hanschmann, Eva-Maria, Boussaad, Ibrahim, Brüstle, Oliver, Giacomello, Marta, Krüger, Rejko, and Methner, Axel

Subjects
mitochondria, cytoskeleton, macromolecular substances, GDAP1, Biochemistry, biophysics & molecular biology [F05] [Life sciences], Biochimie, biophysique & biologie moléculaire [F05] [Sciences du vivant]
Abstract

Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative glutathione transferase, which affects mitochondrial shape and alters cellular Ca2+ homeostasis. Here, we identify the underlying mechanism. We found that patient-derived motoneurons and GDAP1 knockdown SH-SY5Y cells display two phenotypes: more tubular mitochondria and a metabolism characterized by glutamine dependence and fewer cytosolic lipid droplets. GDAP1 interacts with the actin-depolymerizing protein Cofilin-1 in a redoxdependent manner, suggesting a role for actin signaling. Consistently, GDAP1 loss causes less F-actin close to mitochondria, which restricts mitochondrial localization of the fission factor dynamin-related protein 1, instigating tubularity. Changes in the actin cytoskeleton also disrupt mitochondria-ER contact sites. This results in lower mitochondrial Ca2+ levels and inhibition of the pyruvate dehydrogenase complex, explaining the metabolic changes upon GDAP1 loss of function. Together, these findings reconcile GDAP1-associated phenotypes and implicate disrupted actin signaling in CMT4A pathophysiology.

Published
2021

32. Elucidation of the photoinduced transformations of Aliskiren in river water using liquid chromatography high-resolution mass spectrometry

Author

Goncalves, Nuno P. F. Iezzi, Lucia Belay, Masho H. Dulio, Valeria Alygizakis, Nikiforos Dal Bello, Federica Medana, Claudio Calza, Paola

Abstract

Aliskiren was selected as a compound of potential concern among a suspect screening list of more than 40,000 substances on a basis of high occurrence, potential risk and the absence of information about its environmental fate. This study investigated the photoinduced degradation of aliskiren in river water samples spiked at trace levels exposed to simulated sunlight. A half-life time of 24 h was observed with both direct and indirect photolysis playing a role on pollutant degradation. Its photo-induced transformation involved the formation of six transformation products (TPs), elucidated by LC-HRMS -resulted from the drug hydroxylation, oxidation and moieties loss with subsequent cyclization structurally. The retrospective suspected analysis performed on a total of 754 environmental matrices evidenced the environmental occurrence of aliskiren and two TPs in surface waters (river and seawater), fresh water, sediments and biota. In silico bioassays suggested that aliskiren degradation undergoes thought the formation of TPs with distinct toxicity comparing with the parent compound. (c) 2021 Published by Elsevier B.V.

Published
2021

33. Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model

Author

Mhd Omar, Nor Adila, Frank, Jan, Kruger, Johanita, Dal Bello, Federica, Medana, Claudio, Collino, Massimo, Zamaratskaia, Galia, Michaelsson, Karl, Wolk, Alicja, Landberg, Rikard, Mhd Omar, Nor Adila, Frank, Jan, Kruger, Johanita, Dal Bello, Federica, Medana, Claudio, Collino, Massimo, Zamaratskaia, Galia, Michaelsson, Karl, Wolk, Alicja, and Landberg, Rikard

Abstract

Scope: A high fructose and galactose intake show adverse metabolic effects in animal models and in humans, but it is yet unknown if addition of fermentable dietary fiber can mitigate such effects. This study investigate the effects of high intakes of fructose and galactose, with/without added fructooligosaccharides (FOS), on metabolic factors, inflammation, and gut integrity markers in rats. Methods and Results: Rats (n = 6/group) receive different carbohydrates at isocaloric conditions for 12 weeks as follows: 1) starch (control), 2) fructose, 3) galactose, 4) starch + FOS (FOS control), 5) fructose + FOS, and 6) galactose + FOS, together with a high amount of n-6 polyunsaturated fatty acids (n-6 PUFA) in all diets except for in 7) starch + olive oil (negative control). The rats fed the galactose and galactose + FOS diets exhibit lower body weight than other groups. High-galactose diets has more pronounced effects on metabolic factors and gut permeability than high-fructose diets. High-fructose diets show less pronounced effect on these selected markers. No differences in inflammatory markers are detected for any of the diets. Conclusions: The results suggest potential adverse effects of high galactose and fructose on metabolic factors and gut integrity markers, but not on inflammation. However, several mechanisms are at play, and general net effects are difficult to determine conclusively for the conditions tested.

Published
2021
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34. Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts

Author

Mastrocola, Raffaella, Mastrocola, Raffaella, Dal Bello, Federica, Cento, Alessia S., Gaens, Katrien, Collotta, Debora, Aragno, Manuela, Medana, Claudio, Collino, Massimo, Wouters, Kristiaan, Schalkwijk, Casper G., Mastrocola, Raffaella, Mastrocola, Raffaella, Dal Bello, Federica, Cento, Alessia S., Gaens, Katrien, Collotta, Debora, Aragno, Manuela, Medana, Claudio, Collino, Massimo, Wouters, Kristiaan, and Schalkwijk, Casper G.

Abstract

High plasma levels of the sphingolipid intermediates ceramide (Cer) and sphingosine-1-phosphate (S1P) are suggested to be involved in the development of insulin resistance (IR). Recent evidence indicates that advanced glycation endproducts (AGEs) can alter the sphingolipids metabolism equilibrium. Since enzymes responsible for sphingolipid rheostat maintenance are highly expressed in liver, we thus investigated whether AGEs accumulation can affect hepatic sphingolipids metabolism in insulin resistant mice. Two different models of IR were examined: genetically diabetic LeptrDb-/- (DbDb) and diet-induced insulin resistant C57Bl/6J mice fed a 60% trans-fat diet (HFD). In addition, a group of HFD mice was supplemented with the anti-AGEs compound pyridoxamine. AGEs were evaluated in the liver by western blotting. Cer and S1P were measured by UHPLC-MS/MS. The expression of RAGE and of enzymes involved in sphingolipid metabolism were assessed by RT-PCR and western blotting. HepG2 cells were used to study the effect of the major AGE N epsilon(carboxymethyl)lysine (CML)-albumin on sphingolipid metabolism and the role of the receptor of AGEs (RAGE). High levels of AGEs and RAGE were detected in the liver of both DbDb and HFD mice in comparison to controls. The expression of enzymes of sphingolipid metabolism was altered in both models, accompanied by increased levels of Cer and S1P. Specifically, ceramide synthase 5 and sphingosine kinase 1 were increased, while neutral ceramidase was reduced. Pyridoxamine supplementation to HFD mice diminished hepatic AGEs and prevented alterations of sphingolipid metabolism and the development of IR. CML administration to HepG2 cells evoked alterations similar to those observed in vivo, that were in part mediated by the binding to RAGE. The present study shows a direct involvement of AGEs in alterations of sphingolipid metabolism associated to the development of IR. The modulation of sphingolipids metabolism through the prevention of AGE

Published
2021

41. GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

Author

Wolf, Christina, primary, Pouya, Alireza, additional, Bitar, Sara, additional, Pfeiffer, Annika, additional, Bueno, Diones, additional, Arndt, Sabine, additional, Tenzer, Stefan, additional, Dal Bello, Federica, additional, Vianello, Caterina, additional, Ritz, Sandra, additional, Schwirz, Jonas, additional, Dobrindt, Kristina, additional, Peitz, Michael, additional, Hanschmann, Eva-Maria, additional, Boussaad, Ibrahim, additional, Brüstle, Oliver, additional, Giacomello, Marta, additional, Krüger, Rejko, additional, and Methner, Axel, additional

Published
2021
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42. Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model

Author

Mhd Omar, Nor Adila, primary, Frank, Jan, additional, Kruger, Johanita, additional, Dal Bello, Federica, additional, Medana, Claudio, additional, Collino, Massimo, additional, Zamaratskaia, Galia, additional, Michaelsson, Karl, additional, Wolk, Alicja, additional, and Landberg, Rikard, additional

Published
2021
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