1. Conditional survival and the prognostic value of serum carcinoembryonic antigen level in oldest old with colorectal cancer
- Author
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Weijing He, Yufei Yang, Qi Liu, Dakui Luo, Qingguo Li, and Xinxiang Li
- Subjects
Conditional survival ,Serum carcinoembryonic antigen ,Prognosis ,Oldest old ,Colorectal cancer ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background To evaluate the clinical value of serum CEA levels and their implications on the diagnostic value of the conventional TNM staging system in the oldest-old patients with colorectal cancer (CRC). Methods The recruited subjects were colorectal cancer patients aged 85 and older. The cutoff value for normal CEA level is 5 ng/mL. Patients with elevated CEA levels were categorized as stage C1, and those with normal CEA levels as stage C0. A number of Cox proportional hazard regression models were established to evaluate the prognosis of different prognostic factors with hazard ratios (HRs) and 95% confidence intervals (CIs). The Kaplan–Meier method was utilized to display the disparate prognostic impact of multiple clinicopathological factors with the log-rank test. Results A total of 17,359 oldest-old patients diagnosed with CRC were recruited from the SEER database. The conditional survival of oldest-old patients with CRC was dismal with a 1-year conditional survival of only 11%, 18%, and 30% for patients surviving 1, 3, and 5 years, respectively. Patients with stage C1 exhibited a 48.5% increased risk of CRC-specific mortality compared with stage C0 (HR = 1.485, 95%CI = 1.393–1.583, using stage C0 patients as the reference, P
- Published
- 2024
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