38 results on '"Dakhil B"'
Search Results
2. Résection d’un goitre thyroïdien ectopique médiastinal, par RATS : à propos de 2 cas
- Author
-
Hadj Dahmane, M., primary, Abdourabi, R., additional, Bagan, P., additional, Dakhil, B., additional, and Zaimi, R., additional
- Published
- 2023
- Full Text
- View/download PDF
3. Intérêt de l’écho-guidage pour accès vasculaire dans la pratique de thérapies interventionnelles endoluminales
- Author
-
Dakhil, B., Couineau, F., Hernigou, J., Bardet, J., Tella, E., and Bagan, P.
- Published
- 2017
- Full Text
- View/download PDF
4. Syndrome d’apnée du sommeil et anévrisme de l’aorte abdominale : étude de la prévalence du syndrome d’apnée du sommeil chez les patients présentant un anévrisme et recherche d’une association. Étude clinique sur 52 patients
- Author
-
Hernigou, J., Dakhil, B., Belmont, L., Couffinhal, J.C., and Bagan, P.
- Published
- 2017
- Full Text
- View/download PDF
5. Chirurgie thoracique ambulatoire : évolution des indications, applications actuelles et limites
- Author
-
Bagan, P., Berna, P., De Dominicis, F., Lafitte, S., Zaimi, R., Dakhil, B., and Das Neves Pereira, J.-C.
- Published
- 2016
- Full Text
- View/download PDF
6. Médiastinite à Aspergillus après lobectomie post immunothérapie pour un cancer du poumon oligométastatique
- Author
-
Masgnaux, C., Boukhiar, H., Dakhil, B., Raynaud, C., Zaimi, R., Kashi-Dakhil, M., and Bagan, P.
- Published
- 2022
- Full Text
- View/download PDF
7. P52 - Évaluation d’un pansement à haut pouvoir d’absorption dans la cicatrisation d’une cavité infectée de pneumonectomie traitée par thoracostomie
- Author
-
Bagan, P., Dakhil, B., and Marie, M.
- Published
- 2017
- Full Text
- View/download PDF
8. Infection de stent artériel périphérique à Propionibacterium granulosum après angioplastie au ballon actif
- Author
-
Hernigou, J., Gordienco, A., Dakhil, B., Longuet, P., Couffinhal, J.-C., and Bagan, P.
- Published
- 2015
- Full Text
- View/download PDF
9. Évaluation d’un pansement à haut pouvoir d’absorption dans la cicatrisation d’une cavité infectée de pneumonectomie traitée par thoracostomie
- Author
-
Bagan, P., primary, Dakhil, B., additional, and Marie, M., additional
- Published
- 2017
- Full Text
- View/download PDF
10. Ulcères des membres inférieurs développés sous inhibiteurs de tyrosine kinase (sunitinib, nilotinib)
- Author
-
Roger, A., primary, Sigal, M.-L., additional, Bagan, P., additional, Sin, C., additional, Bilan, P., additional, Dakhil, B., additional, Fargeas, C., additional, Couffinhal, J.-C., additional, and Mahé, E., additional
- Published
- 2017
- Full Text
- View/download PDF
11. La phlébite bleue
- Author
-
Zeboulon, C., Amy de la Bretèque, M., Bilan, P., Sin, C., Linder, J.-F., Dakhil, B., Sigal, M.-L., and Mahé, E.
- Published
- 2014
- Full Text
- View/download PDF
12. Résection thoracoscopique ambulatoire de nodules pulmonaires dans le cadre de la réhabilitation précoce
- Author
-
Bardet, J., primary, Zaimi, R., additional, Dakhil, B., additional, Couffinhal, J.C., additional, Raynaud, C., additional, and Bagan, P., additional
- Published
- 2016
- Full Text
- View/download PDF
13. P-279PROGNOSTIC FACTORS AND SCORING SYSTEM FOR ACUTE AND CHRONIC PAIN FOLLOWING LOBECTOMY
- Author
-
Zaimi, Rym, primary, Bagan, P., additional, Dedominicis, F., additional, Hernigou, J., additional, Dakhil, B., additional, Bardet, J., additional, Fourdrain, A., additional, and Berna, P., additional
- Published
- 2015
- Full Text
- View/download PDF
14. Infection de stent artériel périphérique post-angioplastie au ballon actif : cas clinique et revue de la littérature
- Author
-
Hernigou, J., primary, Gordienco, A., additional, Dakhil, B., additional, Longuet, P., additional, Couffinhal, J.C., additional, and Bagan, P., additional
- Published
- 2014
- Full Text
- View/download PDF
15. Prévalence du syndrome d’apnée du sommeil chez les patients pris en charge pour anévrysme de l’aorte abdominale
- Author
-
Hernigou, J., primary, Gordienco, A., additional, Dakhil, B., additional, Couffinhal, J.C., additional, Belmont, L., additional, and Bagan, P., additional
- Published
- 2014
- Full Text
- View/download PDF
16. Réhabilitation et VNI avant exérèse pulmonaire chez les patients à haut risque opératoire
- Author
-
Bagan, P., primary, Oltean, V., additional, Ben Abdesselam, A., additional, Dakhil, B., additional, Raynaud, C., additional, Couffinhal, J.-C., additional, and De Crémoux, H., additional
- Published
- 2013
- Full Text
- View/download PDF
17. Infection de stent artériel périphérique à Propionibacterium granulosumaprès angioplastie au ballon actif
- Author
-
Hernigou, J., Gordienco, A., Dakhil, B., Longuet, P., Couffinhal, J.-C., and Bagan, P.
- Abstract
Les stents périphériques nus sont utilisés dans le traitement des sténoses artérielles symptomatiques. La technique mini-invasive de pose de ce matériel a permis de diminuer la morbidité postopératoire par rapport à la chirurgie prothétique par abord direct, surtout d’un point de vue infectieux. Nous rapportons ici le cas d’une infection d’endoprothèse vasculaire après angioplastie au ballon actif justifiant une revue de la littérature.
- Published
- 2015
- Full Text
- View/download PDF
18. Médiastinite à Aspergillusaprès lobectomie post immunothérapie pour un cancer du poumon oligométastatique
- Author
-
Masgnaux, C., Boukhiar, H., Dakhil, B., Raynaud, C., Zaimi, R., Kashi-Dakhil, M., and Bagan, P.
- Abstract
La relation entre la maladie infectieuse et l’immunothérapie avec les inhibiteurs de points de contrôle immunitaire reste inconnue. Nous rapportons ici le cas d’une femme de 50ans atteinte d’un adénocarcinome pulmonaire métastatique qui a remarquablement répondu à l’immunothérapie et qui a bénéficié d’une lobectomie supérieure droite. Trois semaines après la sortie de l’hôpital, elle a été réadmise pour une dyspnée sévère due à une compression de la bronche souche droite par une masse médiastinale. L’analyse histologie d’une ponction transbronchique a révélé la présence d’Aspergillus fumigatus. Après six mois de traitement par voriconazole, elle a vu ses symptômes s’améliorer avec la régression de la compression bronchique. La progression postopératoire d’une pseudo-masse tumorale chez les patients traités par immunothérapie au long cours peut être liée à une maladie infectieuse opportuniste et doit être évoquée.
- Published
- 2022
- Full Text
- View/download PDF
19. Devenir des patients après une chirurgie pulmonaire. Impact de la réadmission non programmée
- Author
-
Bagan, P., Zaimi, R., and Dakhil, B.
- Abstract
Les réadmissions non planifiées après une intervention chirurgicale pour cancer pulmonaire altèrent le rétablissement postopératoire normal et sont associées à une augmentation de la mortalité post opératoire.
- Published
- 2021
- Full Text
- View/download PDF
20. Three-Dimensional Holographic-Guided Robotic Lung Segmentectomy for Deep Pulmonary Nodules: Technique and Initial Results.
- Author
-
Bagan P, Aissa K, Essid R, Azbabay W, Zaimi R, and Dakhil B
- Subjects
- Humans, Female, Aged, Male, Middle Aged, Tomography, X-Ray Computed, Surgery, Computer-Assisted methods, Surgery, Computer-Assisted instrumentation, Robotic Surgical Procedures methods, Robotic Surgical Procedures instrumentation, Holography methods, Imaging, Three-Dimensional methods, Pneumonectomy methods, Pneumonectomy instrumentation, Lung Neoplasms surgery, Lung Neoplasms diagnostic imaging, Lung Neoplasms pathology
- Abstract
Background: Diagnosis and treatment of small and isolated lung nodules remain challenging issues. Purpose: The aim of this article is to report the technique of real-time navigation using holographic reconstruction technology combined with a robot assisted thoracic surgery (RATS) platform for lung resection in patients with small deep nodules . Research Design: The pre-surgery 3D planning was based on the chest CT scan. The reconstruction was uploaded to a head-mounted display for real-time navigation during mini invasive robot assisted surgery performed with an open console platform. We evaluated this technique with the success rate of diagnosis, the operative time and the post-operative course. Study Sample: This technique was performed in 6 patients (4 female, mean age 65 years) to date. Results: The precision of the head-mounted display based localization system was effective in all cases without the need of open conversion. The mean diameter of the nodules was 8 mm (6-9). The diagnosis was a lung cancer (n = 5) and tuberculoma (n = 1). The mean operative time was 125 min (100-145). The mean hospital stay was 2.5 days (1-3). Conclusions: In conclusion, the intraoperative navigation using the 3D holographic assistance was an helpful tool for mini invasive RATS lung segmentectomy without the need of preoperative localization., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
21. [Aspergillus mediastinitis following post-immunotherapy lobectomy for oligometastatic lung].
- Author
-
Masgnaux C, Boukhiar H, Dakhil B, Raynaud C, Zaimi R, Kashi-Dakhil M, and Bagan P
- Subjects
- Aspergillus, Female, Humans, Immunotherapy, Lung pathology, Middle Aged, Lung Neoplasms complications, Lung Neoplasms pathology, Lung Neoplasms surgery, Mediastinitis diagnosis, Mediastinitis etiology, Mediastinitis therapy
- Abstract
The relationship between infectious disease and therapy with immune checkpoint inhibitors remains unknown. We report the case of a 50-year-old woman with metastatic lung adenocarcinoma who responded remarkably well to immunotherapy and underwent upper right lobectomy. Three weeks after hospital discharge, she was readmitted for severe dyspnea due to mainstem bronchus compression by mediastinal mass. Histological analysis of transbronchial needle aspiration revealed A. fumigatus. After six months of voriconazole regimen, her symptoms improved with the regression of bronchial compression. Postoperative progression of pseudo-tumoral mass in patients treated with long-term immunotherapy may be related to opportunistic infectious disease and requires investigation., (Copyright © 2022. Published by Elsevier Masson SAS.)
- Published
- 2022
- Full Text
- View/download PDF
22. [Patient outcomes after lung resection. The impact of unplanned readmission].
- Author
-
Bagan P, Zaimi R, and Dakhil B
- Subjects
- Databases, Factual, Humans, Lung, Patient Discharge, Retrospective Studies, Risk Factors, Patient Readmission, Postoperative Complications epidemiology
- Abstract
Unplanned readmissions after lung cancer surgery impair normal postoperative recovery and are associated with increased postoperative mortality. The objective of this review was to compile a detailed and comprehensive dataset on unplanned readmissions after pulmonary resection so as to better understand the associated factors and how they may be attenuated. Based on the identified risk factors, prevention involves improved preoperative preparation of at-risk patients and preoperative discharge planning so as to help prevent unscheduled readmissions, which are predictive of a poorer prognosis., (Published by Elsevier Masson SAS.)
- Published
- 2022
- Full Text
- View/download PDF
23. An Unusual Presentation of Mycotic Popliteal Artery Pseudoaneurysm due to Pasteurella multocida Infection.
- Author
-
Orgiu A, Zanier T, Kashi-Dakhil M, Zaimi R, Dakhil B, Longuet P, and Bagan P
- Abstract
Pasteurella multocida , a zoonotic infectious pathogen, is a rare cause of mycotic aneurysms in human hosts. A 76-year-old man was admitted at our emergency unit for a superinfection of his right limb. The patient was initially treated for a knee arthritis. After a first-line antibiotherapy, the patient was referred to the vascular department for the management of a right acute limb ischemia. The work-up revealed a ruptured pseudoaneurysm of the popliteal artery. The ruptured artery was surgically explanted, and a femoropopliteal bypass was then performed. Pasteurella multocida was detected after bacterial analysis of the aneurysm. The postoperative course was uneventful. This case is the first reported case, to our knowledge, of a popliteal artery pseudoaneurysm due to Pasteurella multocida infection., Competing Interests: Conflict of Interest None declared., (International College of Angiology. This article is published by Thieme.)
- Published
- 2020
- Full Text
- View/download PDF
24. [Leiomyosarcoma and angiomyomatous hamartoma: An hasardous association?]
- Author
-
Petitjean M, Kashi-Dakhil M, Hachemane S, Dakhil B, Zaimi R, and Bagan P
- Subjects
- Aged, 80 and over, Angiomyoma diagnostic imaging, Angiomyoma pathology, Femoral Vein diagnostic imaging, Femoral Vein surgery, Hamartoma diagnostic imaging, Hamartoma pathology, Humans, Leiomyosarcoma diagnostic imaging, Leiomyosarcoma pathology, Leiomyosarcoma surgery, Lymph Nodes pathology, Lymphatic Diseases diagnostic imaging, Lymphatic Diseases pathology, Male, Neoplasms, Multiple Primary diagnostic imaging, Neoplasms, Multiple Primary pathology, Positron-Emission Tomography, Pseudolymphoma complications, Pseudolymphoma diagnostic imaging, Pseudolymphoma pathology, Vascular Neoplasms diagnostic imaging, Vascular Neoplasms pathology, Vascular Neoplasms surgery, Angiomyoma complications, Femoral Vein pathology, Hamartoma complications, Leiomyosarcoma complications, Lymphatic Diseases complications, Lymphedema etiology, Vascular Neoplasms complications
- Published
- 2020
- Full Text
- View/download PDF
25. Severe arterial thrombosis associated with Covid-19 infection.
- Author
-
Kashi M, Jacquin A, Dakhil B, Zaimi R, Mahé E, Tella E, and Bagan P
- Subjects
- Betacoronavirus, COVID-19, Coronavirus Infections, Humans, Incidence, Intensive Care Units, Pandemics, Pneumonia, Viral, SARS-CoV-2, Critical Illness, Thrombosis
- Published
- 2020
- Full Text
- View/download PDF
26. Long-term survival following lung surgery for cancer in high-risk patients after perioperative pulmonary rehabilitation.
- Author
-
Marhic A, Dakhil B, Plantefeve G, Zaimi R, Oltean V, and Bagan P
- Subjects
- Adult, Aged, Female, Follow-Up Studies, Forced Expiratory Volume, France epidemiology, Humans, Lung surgery, Lung Neoplasms mortality, Lung Neoplasms rehabilitation, Male, Middle Aged, Prospective Studies, Respiratory Function Tests, Survival Rate trends, Time Factors, Lung physiopathology, Lung Neoplasms surgery, Pneumonectomy methods
- Abstract
Objectives: The benefits of a rehabilitation programme before lung surgical resection for cancer remain to be defined. The purpose of this observational study was to assess the efficacy of preoperative rehabilitation and postoperative rehabilitation on short- and long-term outcomes in patients who were at high operative risk., Methods: Between January 2010 and December 2012, 20 consecutive non-operable patients (16 men and 4 women, mean age 66 years) with clinical N0 lung cancer were included. Eligibility criteria were lung function below guideline thresholds and/or associated severe comorbidities. The protocol included a cardiorespiratory perioperative rehabilitation programme. These patients were followed up at 5 years., Results: The average increase in forced expiratory volume (FEV)1 and of VO2max preoperatively was 12% and 3.5 ml/kg/min, respectively. All patients underwent a pulmonary surgical resection procedure. The morbidity and mortality rates were 20% and 5%, respectively. Nineteen patients returned home upon the completion of postoperative rehabilitation. After 5-year follow-up, the Kaplan-Meier 5-year survival rate was 52%., Conclusions: Perioperative pulmonary rehabilitation seems to allow surgical management of lung cancer by lung resection in first-line, non-eligible patients. The long-term survival of operated high-risk patients is encouraging despite the high complication rate.
- Published
- 2019
- Full Text
- View/download PDF
27. Risk of vascular injury when screw drilling for tibial tuberosity transfer.
- Author
-
Hernigou J, Chahidi E, Kashi M, Moest E, Dakhil B, Hayek G, Callewier A, Schuind F, and Bath O
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Imaging, Three-Dimensional methods, Intraoperative Complications prevention & control, Knee Joint blood supply, Male, Middle Aged, Orthopedic Procedures adverse effects, Retrospective Studies, Risk Assessment methods, Tibia diagnostic imaging, Tomography, X-Ray Computed methods, Vascular System Injuries etiology, Young Adult, Arteries diagnostic imaging, Bone Screws adverse effects, Knee Joint diagnostic imaging, Tibia surgery, Vascular System Injuries prevention & control
- Abstract
Purpose: During tibial tubercle transfer, popliteal vessels are at risk from drills and screws. The risk is around 0.11%, as described in the literature. We reviewed knee injected CT scan for analysis of the location of arteries, identified landmarks allowing minimizing risks, and defined a safe zone., Material and Method: Distances between the posterior cortex and arteries were measured on CT scans from 30 adults (60 knees) at three levels (proximal part of the tibial tuberosity, 20 mm and 40 mm distally). Data were used to create a "risk map" with different angular sectors where the frequency of the presence of arteries was analyzed in each area. We also analyzed the position of 68 screws of 47 patients who underwent a medial tibial tuberosity transfer., Results: The nearest distance between artery and the posterior tibial cortex was found at the level corresponding to the top of the tuberosity with less than 1 mm, while the largest distance was found at the distal level. We were able to define a safe zone for drilling through the posterior tibial cortex which allows a safe fixation for the screws. This zone corresponds to the medial third of the posterior cortex. When the safe zone is not respected, screws that overtake the posterior cortex may be close to arteries as observed for 37 of the 68 screws analyzed., Conclusion: We described new landmarks and recommendations to avoid this complication during tibial tuberosity transfer.
- Published
- 2018
- Full Text
- View/download PDF
28. [Leg ulcers occurring under tyrosine kinase inhibitor therapy (sunitinib, nilotinib)].
- Author
-
Roger A, Sigal ML, Bagan P, Sin C, Bilan P, Dakhil B, Fargeas C, Couffinhal JC, and Mahé E
- Subjects
- Aged, 80 and over, Antineoplastic Agents administration & dosage, Bile Duct Neoplasms drug therapy, Cholangiocarcinoma drug therapy, Female, Humans, Indoles administration & dosage, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Male, Middle Aged, Pyrimidines administration & dosage, Pyrroles administration & dosage, Sunitinib, Withholding Treatment, Wound Healing, Antineoplastic Agents adverse effects, Indoles adverse effects, Leg Ulcer chemically induced, Pyrimidines adverse effects, Pyrroles adverse effects
- Abstract
Background: Certain anticancer drugs are known to induce leg ulcers, mainly chemotherapy agents such as hydroxyurea. We report 2 cases of leg ulcers in cancer patients treated with the tyrosine kinase inhibitors, sunitinib and nilotinib, and we discuss the role of these treatments in the pathogenesis of leg ulcers., Patients and Methods: Case 1. A 62-year-old patient on sunitinib for intrahepatic cholangiocarcinoma developed a lesion on her right foot. The vascular evaluation was negative. After progressive worsening, sunitinib was stopped and healing was observed within a few months. Case 2. A 83-year-old patient had been treated for chronic myeloid leukemia since 2005. Nilotinib was introduced in 2009. Peripheral arterial revascularization was required in May 2013. A few months later, worsening was noted with the onset of ulceration and necrosis of the third toe. Further revascularisation surgery was performed, and nilotinib was suspended and antiplatelets introduced. Healing occurred a few months later., Discussion: Many skin reactions have been described in patients on nilotinib and sunitinib, but few publications report the development of de novo ulcers in patients without risk factors. The pathophysiology of the development of ulcers in patients receiving tyrosine kinase inhibitors is not clear, and probably involves several mechanisms of action. The increasing use of this type of treatment could lead to an upsurge in the incidence of vascular complications., Conclusion: We report two cases of leg ulcers developing in patients on tyrosine kinase inhibitors and raise the question of causal implication of these treatments in the pathogenesis of ulcers., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
29. [Outpatient thoracic surgery: Evolution of the indications, current applications and limits].
- Author
-
Bagan P, Berna P, De Dominicis F, Lafitte S, Zaimi R, Dakhil B, and Das Neves Pereira JC
- Subjects
- Humans, Patient Selection, Postoperative Complications epidemiology, Postoperative Complications etiology, Practice Guidelines as Topic, Thoracic Surgery, Video-Assisted statistics & numerical data, Ambulatory Surgical Procedures methods, Ambulatory Surgical Procedures standards, Ambulatory Surgical Procedures statistics & numerical data, Ambulatory Surgical Procedures trends, Thoracic Surgical Procedures methods, Thoracic Surgical Procedures standards, Thoracic Surgical Procedures statistics & numerical data, Thoracic Surgical Procedures trends
- Abstract
The objectives of outpatient surgery are to reduce the risks connected to hospitalization, to improve postoperative recovery and to decrease the health costs. Few studies have been performed in the field of thoracic surgery and there remains great scope for progress in outpatient lung surgery. The purpose of this article is to present a revue of the current situation and the prospects for the development of out patient thoracic surgery., (Copyright © 2016 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
30. [Outpatient thoracoscopic resection of lung nodules within a fast-track recovery program].
- Author
-
Bardet J, Zaimi R, Dakhil B, Couffinhal JC, Raynaud C, and Bagan P
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Multiple Pulmonary Nodules rehabilitation, Operative Time, Patient Discharge, Pneumonectomy methods, Retrospective Studies, Thoracoscopy methods, Thoracoscopy rehabilitation, Time Factors, Ambulatory Care methods, Critical Pathways organization & administration, Critical Pathways standards, Multiple Pulmonary Nodules surgery, Pneumonectomy rehabilitation, Thoracic Surgery, Video-Assisted rehabilitation
- Abstract
Introduction: The objectives of outpatient surgery are to reduce the risks related to the hospitalization, to improve the postoperative recovery and to optimize contact with family physicians. The objective of this work is to present the first unit of outpatient pulmonary surgery and to report the results of the resections of pulmonary nodules in outpatient surgery in the setting of early discharge., Methods: The indications for the resection of nodules were discussed in a multidisciplinary thoracic oncology meeting. The patients underwent resection of one or more lung nodules by thoracoscopy after verification that they met the anaesthetic and surgical criteria for ambulatory surgery. We analyzed the characteristics of the population, the duration of surgery, the type of resection, the time of the chest drain removal and the postoperative follow-up., Results: Between November 2013 and December 2014, 51 patients underwent sub-lobar pulmonary resections. Among them 7 patients (4 men and 3 women), with an average age of 57.6 years (39-64) and histories of malignant tumor, underwent 7 atypical resections and two segmentectomies in outpatient surgery (3 patients had two resections). The average operating time was 53.75min (30-90). The chest drain was removed before the third hour in 8 cases and on the third day in one case. The average tumor diameter was 10.375mm (6-23). The histology revealed a metastasis of colorectal carcinoma in 4 cases, a metastasis of a renal carcinoma in 1 case, an in situ adenocarcinoma in 1 case and a benign tumor in 3 cases. Neither recurrence nor complication was observed during an average follow-up of 6 months., Conclusion: Thanks to a protocol of early mobilisation and discharge included in a well established clinical care pathway, thoracoscopic resection of lung nodules is feasible, with safety in properly selected and prepared patients in outpatient surgery., (Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
31. Protective effect of the methanolic extract of malva parviflora l. leaves on acetic acid-induced ulcerative colitis in rats.
- Author
-
Dugani A, Dakhil B, and Treesh S
- Subjects
- Acetic Acid toxicity, Animals, Colitis, Ulcerative chemically induced, Colon drug effects, Disease Models, Animal, Drug Evaluation, Preclinical, Male, Methanol chemistry, Organ Size drug effects, Plant Leaves chemistry, Random Allocation, Rats, Rats, Wistar, Colitis, Ulcerative prevention & control, Malva chemistry, Plant Extracts chemistry, Plant Extracts pharmacology
- Abstract
Background/aims: Inflammatory bowel disease (IBD) is a general term describing chronic, idiopathic relapsing, inflammatory conditions of the gastrointestinal tract of unknown etiology. Previous studies have indicated that Malva parviflora leaf extract possesses anti-inflammatory, antioxidant, and antiulcerogenic activity. activity. This work aimed to investigatee the anti-inflammatory effect of the methanolic (MEMP) and aqueous (AEMP) extracts of M. parviflora leaves on acetic acid-induced colitis in rats., Materials and Methods: 42 male Wistar albino rats were divided into seven groups (n = 6). Group I: Normal saline control group with no colitis; Group II: Acetic acid colitis group; Group III: 100 mg/kg/5 d MEMP; Group IV: 200 mg/kg/5 d.MEMP; Group V: 100 mg/kg/5 d AEMP; Group VI: 200 mg/kg/5 d AEMP; Group VII: Prednisolone group (2 mg/kg/5 d). Treatments were followed by induction of colitis using intrarectal instillation of 2 mL of 4% acetic acid. Colon damage was evaluated macroscopically (spleen weight/body weight, colon weight/length ratio) and the histological changes were also recorded., Results: The results of this study showed that acetic acid caused severe inflammation of the colon and a significant increase in spleen weight/body weight, and an increase in colon weight/length ratio compared with normal control group. Pretreatment with MEMP and AEMP for 5 days followed by induction of colitis resulted in a significant attenuation of spleen weight and colon weight/length ratio compared with acetic acid control group. Methanolic extract provided better anticolitic effect than aqueous extract; the effect was prominent at the dose of 200 mg/kg. Histopathological findings confirmed the protective effect of the MEMP., Conclusion: In conclusion, MEMP could ameliorate mucosal damage in experimentally induced colitis when given orally.
- Published
- 2016
- Full Text
- View/download PDF
32. [Propionibacterium granulosum bare-metal stent infection after drug-eluting balloon].
- Author
-
Hernigou J, Gordienco A, Dakhil B, Longuet P, Couffinhal JC, and Bagan P
- Subjects
- Aged, 80 and over, Alloys, Amoxicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Arteriosclerosis Obliterans complications, Arteriosclerosis Obliterans surgery, Bacteremia etiology, Bacteremia microbiology, Coronary Disease complications, Coronary Disease therapy, Coronary Restenosis therapy, Device Removal, Equipment Contamination, Female, Femoral Artery surgery, Gentamicins therapeutic use, Gram-Positive Bacterial Infections diagnostic imaging, Gram-Positive Bacterial Infections drug therapy, Gram-Positive Bacterial Infections microbiology, Humans, Immunosuppressive Agents adverse effects, Paclitaxel administration & dosage, Paclitaxel therapeutic use, Penicillanic Acid analogs & derivatives, Penicillanic Acid therapeutic use, Piperacillin therapeutic use, Piperacillin, Tazobactam Drug Combination, Popliteal Artery diagnostic imaging, Popliteal Artery surgery, Propionibacterium pathogenicity, Prosthesis-Related Infections diagnostic imaging, Prosthesis-Related Infections drug therapy, Prosthesis-Related Infections microbiology, Tomography, Emission-Computed, Single-Photon, Angioplasty, Balloon, Coronary adverse effects, Gram-Positive Bacterial Infections etiology, Paclitaxel adverse effects, Propionibacterium isolation & purification, Prosthesis-Related Infections etiology, Stents adverse effects
- Abstract
Introduction: Bare-metal stents are used to treat arterial stenotic lesions. Morbidity and mortality are less important compared with other techniques. Drug-eluting balloons are often used to treat stent stenosis. We reported the case of a bare-metal stent infection after drug-eluting balloon and a review on the subject., Material and Method: Two weeks after percutaneous transluminal angioplasty with paclitaxel-eluting balloon and a bare-metal stent, our patient presented an infection of the stent. Diagnosis was based on the clinical presentation, positron emission tomography findings and isolation of Propionibacterium granulosum in repeated blood cultures. Adapted antibiotic therapy was given for three months with removal of the surgical bare-stent. Antibiotic therapy was interrupted after a second positron emission tomography. A literature search (PubMed and Cochrane) was performed on the subject., Results: We found 49 cases of peripheral bare-metal stent infection including our patient. This is a rare but serious complication with a high morbidity (25% amputation rate) and mortality (30%). It seems to be underestimated. Treatment is based on surgical ablation of the bare-metal stent and intravenous antibiotics. The role of the paclitaxel-eluting balloon is not clearly established but some authors believe that it can produce a local immunosuppression., Conclusion: We report the first case of bare-metal stent infection after paclitaxel-eluting balloon. This complication is rare and difficult to diagnose. Manifestations are often limited to skin signs. Functional and vital prognosis is poor., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
33. Complete thoracoscopic lobectomy for cancer: comparative study of three-dimensional high-definition with two-dimensional high-definition video systems †.
- Author
-
Bagan P, De Dominicis F, Hernigou J, Dakhil B, Zaimi R, Pricopi C, Le Pimpec Barthes F, and Berna P
- Subjects
- Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung pathology, Chest Tubes, Clinical Competence, Drainage instrumentation, Equipment Design, Female, France, Humans, Image Interpretation, Computer-Assisted, Learning Curve, Length of Stay, Lung Neoplasms pathology, Lymph Node Excision, Male, Middle Aged, Neoplasm Staging, Operative Time, Pneumonectomy adverse effects, Pneumonectomy methods, Prospective Studies, Thoracic Surgery, Video-Assisted adverse effects, Thoracic Surgery, Video-Assisted methods, Time Factors, Treatment Outcome, Carcinoma, Non-Small-Cell Lung surgery, Imaging, Three-Dimensional, Lung Neoplasms surgery, Pneumonectomy instrumentation, Thoracic Surgery, Video-Assisted instrumentation, Thoracoscopes
- Abstract
Objectives: Common video systems for video-assisted thoracic surgery (VATS) provide the surgeon a two-dimensional (2D) image. This study aimed to evaluate performances of a new three-dimensional high definition (3D-HD) system in comparison with a two-dimensional high definition (2D-HD) system when conducting a complete thoracoscopic lobectomy (CTL)., Methods: This multi-institutional comparative study trialled two video systems: 2D-HD and 3D-HD video systems used to conduct the same type of CTL. The inclusion criteria were T1N0M0 non-small-cell lung carcinoma (NSCLC) in the left lower lobe and suitable for thoracoscopic resection. The CTL was performed by the same surgeon using either a 3D-HD or 2D-HD system. Eighteen patients with NSCLC were included in the study between January and December 2013: 14 males, 4 females, with a median age of 65.6 years (range: 49-81). The patients were randomized before inclusion into two groups: to undergo surgery with the use of a 2D-HD or 3D-HD system. We compared operating time, the drainage duration, hospital stay and the N upstaging rate from the definitive histology., Results: The use of the 3D-HD system significantly reduced the surgical time (by 17%). However, chest-tube drainage, hospital stay, the number of lymph-node stations and upstaging were similar in both groups., Conclusions: The main finding was that 3D-HD system significantly reduced the surgical time needed to complete the lobectomy. Thus, future integration of 3D-HD systems should improve thoracoscopic surgery, and enable more complex resections to be performed. It will also help advance the field of endoscopically assisted surgery., (© The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
34. [Phlegmasia cerulea dolens].
- Author
-
Zeboulon C, Amy de la Bretèque M, Bilan P, Sin C, Linder JF, Dakhil B, Sigal ML, and Mahé E
- Subjects
- Aged, Carcinoma secondary, Carcinoma surgery, Diagnosis, Differential, Edema diagnosis, Femoral Vein diagnostic imaging, Humans, Iliac Vein diagnostic imaging, Leg Ulcer diagnosis, Lymphatic Metastasis pathology, Male, Ultrasonography, Doppler methods, Urinary Bladder Neoplasms surgery, Urothelium pathology, Arteritis diagnostic imaging, Ischemia diagnostic imaging, Leg blood supply, Thrombophlebitis diagnostic imaging, Venous Thrombosis diagnostic imaging
- Abstract
Background: Herein we report a case of phlegmasia cerulea dolens, a form of venous thrombosis complicated by arterial ischaemia., Patients and Methods: A 69-year-old man presented a bilateral trophic condition of the lower limbs that had appeared 3 weeks earlier. The patient had a history of metastatic urothelial bladder carcinoma and arteritis. Clinical examination revealed right leg ulcers with massive bilateral oedema of the lower limbs, cyanosis and local ischaemia. Doppler ultrasound revealed bilateral and proximal deep vein thrombosis (sural and superficial femoral veins of the right leg; sural and iliac veins of the left leg) without any distal arterial flow. We concluded on a diagnosis of bilateral phlegmasia cerulea dolens., Discussion: Phlegmasia cerulea dolens is a particular type of deep venous thrombosis in which a proximal venous thrombus is combined with arterial ischaemic signs due to brutal and massive oedema and slowing down of arterial flow. In most cases, the lower limbs are involved, with malignancy being the most common cause. It should be suspected in the presence of the classical triad of "pain, oedema and cyanosis", with confirmation by Doppler ultrasound. There is no general consensus regarding standard management. Traditionally, systemic anticoagulation has been the mainstay of treatment for this condition. Endovascular surgery may be a possibility in some cases. Prompt diagnosis and rapid treatment initiation are paramount in order to improve the prognosis of this severe condition with ominous prospects., (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
35. QTc compared to JTc for monitoring drug-induced repolarization changes in the setting of ventricular pacing.
- Author
-
Tsai SF, Houmsse M, Dakhil B, Augostini R, Hummel JD, Kalbfleisch SJ, Liu Z, Love C, Rhodes T, Tyler J, Weiss R, Hamam I, Winner M, and Daoud EG
- Subjects
- Aged, Electrocardiography, Female, Humans, Male, Anti-Arrhythmia Agents therapeutic use, Heart Conduction System drug effects, Pacemaker, Artificial, Phenethylamines therapeutic use, Sotalol therapeutic use, Sulfonamides therapeutic use
- Abstract
Background: QT prolongation is a risk factor for proarrhythmia when beginning antiarrhythmic drug therapy (AAD). However, there are no data regarding monitoring repolarization changes during a ventricular paced (VP) rhythm., Objective: The purpose of this study was to compare serial changes in corrected QT and JT intervals, during native conduction (NC) and VP rhythms when initiating Class III AADs., Methods: Twenty-two patients (73% men; mean age 65 ± 11 years) with an implantable device and with <10% VP were monitored during AAD initiation (16 sotalol, 6 dofetilide). QTc and JTc were measured from ECGs obtained during NC and VP at baseline (pre-AAD) and then after each AAD dose., Results: During AAD loading, mean QTc increased significantly during NC (431 ± 28 ms to 463 ± 33 ms, P = .002) but not with VP (520 ± 48 ms to 538 ± 45 ms, P = .07). Mean percent increase in peak QTc during NC was significantly greater than during VP (12% vs 7%, P = .003). In contrast, peak JTc during AAD loading was not significantly different between NC and VP (P = .67)., Conclusion: When initiating AAD, the change in QTc during VP does not correlate with the change in QTc during NC; thus, the VP QTc is inadequate for monitoring repolarization changes. However, VP JTc correlates well with JTc during NC. When initiating Class III AADs in patients with VP rhythms, the JTc, and not the QTc, interval is the useful marker for assessing repolarization., (© 2013 Heart Rhythm Society Published by Heart Rhythm Society All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
36. Evaluation of balloon catheter-guided intra-arterial thrombolysis for acute peripheral arterial occlusion.
- Author
-
Dakhil B, Lacal P, Abdesselam AB, Couffinhal JC, Gordienco A, and Bagan P
- Subjects
- Acute Disease, Adult, Aged, Aged, 80 and over, Angiography, Arterial Occlusive Diseases diagnostic imaging, Equipment Design, Female, Humans, Male, Middle Aged, Treatment Outcome, Arterial Occlusive Diseases drug therapy, Catheterization, Peripheral methods, Catheters standards, Fibrinolytic Agents administration & dosage, Leg blood supply
- Abstract
Background: The objective of this study was to evaluate the effectiveness of a new method of in situ thrombolysis using a porous balloon with low pressure compared with traditional in situ infusion of a fibrinolytic agent in the treatment of acute limb ischemia., Methods: Between January 2010 and December 2011, 14 patients (mean age, 67.2 years; range, 40-89 years) treated for grade II acute lower limb ischemia for fewer than 14 days were included in the study. Thromboaspiration was tried initially in all the cases. All patients benefitted from a novel method of intra-arterial thrombolysis guided with a balloon catheter (ClearWay; Atrium Medical, Hudson, NH) and using the same agent thrombolytic (Actosolv). The total amount injected, the rate of morbidity associated with the thrombolytic treatment, and the duration of hospitalization in the continuous monitoring unit were analyzed., Results: Recanalization was obtained in 92% of cases (13 of 14). The rate of morbidity related to the procedure was 7%. The amount of fibrinolytic agent necessary was relatively low (82,000 units/cm of occluded artery). The rate of limb salvage 6 months after recanalization was of 92%. The mean duration of stay in the continuous monitoring unit was 1.1 day., Conclusions: Intra-arterial thrombolysis using the ClearWay balloon catheter is an effective method in the treatment of acute peripheral arterial occlusion. In the event of embolic occlusion, mainly among very old patients, it could decrease the hemorrhagic risk. A randomized study in these high-risk patients could confirm these first results., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
37. Acute peripheral arterial occlusion: prospective study evaluating intra-arterial thrombolysis with a micro-porous balloon catheter.
- Author
-
Bagan P, Dakhil B, Lacal P, and Couffinhal JC
- Subjects
- Acute Disease, Adult, Aged, Aged, 80 and over, Equipment Design, Female, Humans, Male, Middle Aged, Porosity, Prospective Studies, Thrombolytic Therapy methods, Arterial Occlusive Diseases therapy, Catheters, Ischemia therapy, Leg blood supply, Peripheral Arterial Disease therapy, Thrombolytic Therapy instrumentation
- Abstract
Purpose: To assess the efficacy of a new in situ thrombolysis method using a low-pressure micro-porous balloon catheter (MPBC) compared to a traditional in situ infusion (ISI) of a fibrinolytic agent in the treatment of acute limb ischemia., Methods: Between January 2010 and December 2011, 21 patients (14 men; mean age 64.6 years, range 40-92) treated for acute lower limb ischemia were prospectively enrolled in the study. Seven patients underwent in situ thrombolysis using the ISI method and 14 patients the MPBC method to deliver urokinase. The total urokinase dose injected and the length of stay in an intermediate care unit were compared between the groups., Results: Recanalization was successful in 90% of cases (6/7 patients in the ISI group; 13/14 patients in the MPBC group). The morbidity was 7% (1 pseudoaneurysm). The dose of urokinase needed was significantly lower (p<0.001) in the MPBC group (0.7±0.44 IU, range 0.15-1.6) vs. the ISI group (1.66±0.71 IU, range 0.2-2). The average length of stay in the intermediate care unit was significantly shorter in the MPBC group (1.2 vs. 3.9 days, p<0.002). The overall 6-month limb salvage rate after recanalization was 90% (83% for the ISI patients vs. 93% for the MPBC group)., Conclusions: Intra-arterial thrombolysis using a balloon catheter is an effective method in the treatment of acute peripheral arterial occlusions. In the case of occlusion caused by embolism, primarily in very elderly patients, it may reduce the risk of hemorrhage. A randomized study on high-risk patients is needed to confirm these initial results.
- Published
- 2013
- Full Text
- View/download PDF
38. [Pulmonary rehabilitation and non-invasive ventilation before lung surgery in very high-risk patients].
- Author
-
Bagan P, Oltean V, Ben Abdesselam A, Dakhil B, Raynaud C, Couffinhal JC, and De Crémoux H
- Subjects
- Adult, Aged, Carcinoma, Bronchogenic epidemiology, Female, Humans, Length of Stay statistics & numerical data, Lung Neoplasms epidemiology, Male, Middle Aged, Noninvasive Ventilation statistics & numerical data, Pneumonectomy statistics & numerical data, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications prevention & control, Preoperative Period, Risk, Carcinoma, Bronchogenic therapy, Lung Neoplasms therapy, Noninvasive Ventilation methods, Pneumonectomy rehabilitation
- Abstract
Introduction: The benefits of a rehabilitation program before surgical lung cancer resection remain to be defined. The purpose of this prospective observational study was to assess the effects of rehabilitation together with the use of noninvasive ventilation (NIV) in patients who were at a high operative risk., Methods: Between January 2010 and June 2011, 20 consecutive patients (16 males, four females, mean age: 66 years [44-79]) with a clinical N0 non-small cell lung cancer were included. Eligibility criteria were predicted post-operative respiratory function (FEV1, VO2 max) below the guideline thresholds for eligibility for surgical resection and/or associated with severe co-morbidities. The protocol included a cardiorespiratory rehabilitation program and 3 hours of NIV each day. Functional tests were repeated after 3 weeks of therapy., Results: Participants displayed a significant increase in their FEV1 and VO2 max, which allowed surgical resection to go ahead in all patients (lobectomy, n=15; pneumonectomy, n=3; bilobectomy, n=2). The morbidity rate was 20% (acute renal failure, n=2; pneumonia, n=1; haemothorax, n=1). The mortality rate was 5% (myocardial infarction, n=1). Further postoperative rehabilitation allowed a return at home in 19 patients after a mean hospital stay of 11 days., Conclusion: Pulmonary rehabilitation associated with a period of preoperative NIV allows surgery to be performed in patients who are not initially eligible for resection. An evaluation of long-term outcomes survival in comparison to non-surgical therapies is necessary., (Copyright © 2013. Published by Elsevier Masson SAS.)
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.