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1. Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron sublineage JN.1 in critically ill COVID-19 patients: a prospective, multicenter cohort study in France, November 2022 to January 2024

Author

de Prost, Nicolas, Audureau, Etienne, Guillon, Antoine, Handala, Lynda, Préau, Sébastien, Guigon, Aurélie, Uhel, Fabrice, Le Hingrat, Quentin, Delamaire, Flora, Grolhier, Claire, Tamion, Fabienne, Moisan, Alice, Darreau, Cédric, Thomin, Jean, Contou, Damien, Henry, Amandine, Daix, Thomas, Hantz, Sébastien, Saccheri, Clément, Giordanengo, Valérie, Pham, Tài, Chaghouri, Amal, Bay, Pierre, Pawlotsky, Jean-Michel, and Fourati, Slim

Published
2024
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2. Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

Author

Bay, Pierre, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Turpin, Matthieu, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Roux, Damien, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Levy, David, Burrel, Sonia, Mayaux, Julien, Kimmoun, Antoine, Hartard, Cédric, Pène, Frédéric, Rozenberg, Flore, Gaudry, Stéphane, Brichler, Ségolène, Guillon, Antoine, Handala, Lynda, Tamion, Fabienne, Moisan, Alice, Daix, Thomas, Hantz, Sébastien, Delamaire, Flora, Thibault, Vincent, Souweine, Bertrand, Henquell, Cecile, Picard, Lucile, Botterel, Françoise, Rodriguez, Christophe, Dessap, Armand Mekontso, Pawlotsky, Jean-Michel, Fourati, Slim, and de Prost, Nicolas

Published
2024
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3. COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

Author

Bay, Pierre, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Turpin, Matthieu, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Roux, Damien, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Levy, David, Burrel, Sonia, Mayaux, Julien, Kimmoun, Antoine, Hartard, Cédric, Pène, Frédéric, Rozenberg, Flore, Gaudry, Stéphane, Brichler, Ségolène, Guillon, Antoine, Handala, Lynda, Tamion, Fabienne, Moisan, Alice, Daix, Thomas, Hantz, Sébastien, Delamaire, Flora, Thibault, Vincent, Souweine, Bertrand, Henquell, Cecile, Picard, Lucile, Botterel, Françoise, Rodriguez, Christophe, Dessap, Armand Mekontso, Pawlotsky, Jean-Michel, Fourati, Slim, and de Prost, Nicolas

Published
2024
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4. Can Biomarkers Correctly Predict Ventilator-associated Pneumonia in Patients Treated With Targeted Temperature Management After Cardiac Arrest? An Exploratory Study of the Multicenter Randomized Antibiotic (ANTHARTIC) Study

Author

Deye, Nicolas, Le Gouge, Amelie, François, Bruno, Chenevier-Gobeaux, Camille, Daix, Thomas, Merdji, Hamid, Cariou, Alain, Dequin, Pierre-François, Guitton, Christophe, Mégarbane, Bruno, Callebert, Jacques, Giraudeau, Bruno, Mebazaa, Alexandre, and Vodovar, Nicolas

Published
2024
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8. Demultiplexing Ig repertoires by parallel mRNA/DNA sequencing shows major differential alterations in severe COVID-19

Author

Pascal, Virginie, Dupont, Marine, de Rouault, Paco, Rizzo, David, Rossille, Delphine, Jeannet, Robin, Daix, Thomas, François, Bruno, Genebrier, Steve, Cornic, Marie, Monneret, Guillaume, Venet, Fabienne, Ferrant, Juliette, Roussel, Mikael, Reizine, Florian, Le Souhaitier, Mathieu, Tadié, Jean-Marc, Tarte, Karin, Feuillard, Jean, and Cogné, Michel

Published
2023
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10. Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variant JN.1 in critically ill COVID-19 patients: a prospective, multicenter cohort study

Author

de Prost, Nicolas, primary, Audureau, Etienne, additional, Guillon, Antoine, additional, Handala, Lynda, additional, Préau, Sébastien, additional, Guigon, Aurélie, additional, Uhel, Fabrice, additional, Hingrat, Quentin Le, additional, Delamaire, Flora, additional, Grolhier, Claire, additional, Tamion, Fabienne, additional, Moisan, Alice, additional, Darreau, Cédric, additional, Thomin, Jean, additional, Contou, Damien, additional, Henry, Amandine, additional, Daix, Thomas, additional, Hantz, Sébastien, additional, Saccheri, Clément, additional, Giordanengo, Valérie, additional, Pham, Tài, additional, Chaghouri, Amal, additional, Bay, Pierre, additional, Pawlotsky, Jean-Michel, additional, and Fourati, Slim, additional

Published
2024
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11. Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in emergency departments

Author

Lafon, Thomas, primary, Chapuis, Nicolas, additional, Guerin, Estelle, additional, Daix, Thomas, additional, Otranto, Marcela, additional, Boumediene, Ahmed, additional, Jeannet, Robin, additional, Fontenay, Michaela, additional, Karam, Henri Hani, additional, Vignon, Philippe, additional, Monneret, Guillaume, additional, François, Bruno, additional, Jais, Jean-Philippe, additional, and Feuillard, Jean, additional

Published
2024
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12. Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection

Author

Roussel, Mikael, Ferrant, Juliette, Reizine, Florian, Le Gallou, Simon, Dulong, Joelle, Carl, Sarah, Lesouhaitier, Matheiu, Gregoire, Murielle, Bescher, Nadège, Verdy, Clotilde, Latour, Maelle, Bézier, Isabelle, Cornic, Marie, Vinit, Angélique, Monvoisin, Céline, Sawitzki, Birgit, Leonard, Simon, Paul, Stéphane, Feuillard, Jean, Jeannet, Robin, Daix, Thomas, Tiwari, Vijay K., Tadié, Jean Marc, Cogné, Michel, and Tarte, Karin

Published
2021
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13. Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in emergency departments.

Author

Lafon, Thomas, Chapuis, Nicolas, Guerin, Estelle, Daix, Thomas, Otranto, Marcela, Boumediene, Ahmed, Jeannet, Robin, Fontenay, Michaela, Hani, Karam Henri, Vignon, Philippe, Monneret, Guillaume, François, Bruno, Jean-Philippe, Jais, and Feuillard, Jean

Subjects
HLA-DR antigens, HOSPITAL emergency services, SARS-CoV-2, LYMPHOPENIA, MONOCYTES
Abstract

Because one-third of patients deteriorate after their admission to the emergency department, assessing the prognosis of COVID-19 patients is of great importance. However, to date, only lymphopenia and the partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio have been reported as partly predictive of COVID-19–related further deterioration, and their association has not been evaluated. We asked whether other key biomarkers of SARS-CoV-2 immunologic defects—increase in circulating immature granulocytes, loss of monocyte HLA-DR (mHLA-DR) expression, and monocyte differentiation blockade—could also predict further COVID-19 deterioration. A series of 284 consecutive COVID-19 patients, with the sole inclusion criterion of being an adult, were prospectively enrolled at emergency department admission (day 0) of 2 different hospitals: 1 for the exploratory cohort (180 patients) and 1 for the confirmatory cohort (104 patients). Deterioration was assessed over the next 7 days. Neither increased immature granulocyte levels nor monocyte differentiation blockade predicted patient worsening. Among more than 30 clinical, biological, and radiological parameters, the value of decreased P/F ratio and lymphopenia for prediction of further COVID-19 deterioration was strongly confirmed, and the loss of mHLA-DR was the only additional independent marker. Combined together in a simple OxyLymphoMono score, the 3 variables perfectly predicted patients who did not worsen and correctly predicted worsening in 59% of cases. By highlighting lymphocyte and monocyte defects as preceding COVID-19 deterioration, these results point on early immunosuppression in COVID-19 deterioration. Combining P/F ratio, lymphopenia, and loss of mHLA-DR together in a simple and robust score could offer a pragmatic method for COVID-19 patient stratification. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Author

Pugin, Jérôme, Daix, Thomas, Pagani, Jean-Luc, Morri, Davide, Giacomucci, Angelo, Dequin, Pierre-François, Guitton, Christophe, Que, Yok-Ai, Zani, Gianluca, Brealey, David, Lepape, Alain, Creagh-Brown, Ben, Wyncoll, Duncan, Silengo, Daniela, Irincheeva, Irina, Girard, Laurie, Rebeaud, Fabien, Maerki, Iwan, Eggimann, Philippe, and François, Bruno

Published
2021
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17. Left ventricular overloading identified by critical care echocardiography is key in weaning-induced pulmonary edema

Author

Goudelin, Marine, Champy, Pauline, Amiel, Jean-Bernard, Evrard, Bruno, Fedou, Anne-Laure, Daix, Thomas, and François, Bruno

Subjects
Wave propagation, Echocardiography, Lung diseases, Obstructive -- Care and treatment, Pulmonary edema -- Care and treatment, Health care industry
Abstract

Purpose To assess the role of left ventricular overload and cumulated fluid balance in the development weaning-induced pulmonary edema (WIPO). Methods Ventilated patients in sinus rhythm with COPD and/or heart failure (ejection fraction [less than or equal to] 40%) were studied. Echocardiography was performed immediately before and during a 30-min spontaneous breathing trial (SBT) using a T-tube. Patients who failed were treated according to echocardiography results before undergoing a second SBT. Results Twelve of 59 patients failed SBT, all of them developing WIPO. Patients who succeeded SBT had lower body weight (- 2.5 kg [- 4.8; - 1] vs. + 0.75 kg [- 2.95; + 5.57]: p = 0.02) and cumulative fluid balance (- 2326 ml [- 3715; + 863] vs. + 143 ml [- 2654; + 4434]: p = 0.007) than those who developed WIPO. SBT-induced central hemodynamic changes were more pronounced in patients who developed WIPO, with higher E wave velocity (122 cm/s [92; 159] vs. 93 cm/s [74; 109]: p = 0.017) and E/A ratio (2.1 [1.2; 3.6] vs. 0.9 [0.8; 1.4]: p = 0.001), and shorter E wave deceleration time (85 ms [72; 125] vs. 147 ms [103; 175]: p = 0.004). After echocardiography-guided treatment, all patients who failed the first SBT were successfully extubated. Fluid balance was then negative (- 2224 ml [- 7056; + 100] vs. + 146 ml [- 2654; + 4434]: p = 0.005). Left ventricular filling pressures were lower (E/E': 7.3 [5; 10.4] vs. 8.9 [5.9; 13.1]: p = 0.028); SBT-induced increase in E wave velocity (+ 10.6% [- 2.7/ + 18] vs. + 25.6% [+ 12.7/ + 49]: p = 0.037) and of mitral regurgitation area were significantly smaller. Conclusion In high-risk patients, WIPO appears related to overloaded left ventricle associated with excessive fluid balance. SBT-induced central hemodynamic changes monitored by CCE help in guiding therapy for successful weaning., Author(s): Marine Goudelin [sup.1] [sup.2], Pauline Champy [sup.1], Jean-Bernard Amiel [sup.1], Bruno Evrard [sup.1] [sup.2], Anne-Laure Fedou [sup.1] [sup.2], Thomas Daix [sup.1] [sup.2], Bruno François [sup.1] [sup.2], Philippe Vignon [sup.1] [...]

Published
2020
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18. Along with PaO2/FiO2ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in emergency departments

Author

Lafon, Thomas, Chapuis, Nicolas, Guerin, Estelle, Daix, Thomas, Otranto, Marcela, Boumediene, Ahmed, Jeannet, Robin, Fontenay, Michaela, Henri Hani, Karam, Vignon, Philippe, Monneret, Guillaume, François, Bruno, Jean-Philippe, Jais, and Feuillard, Jean

Abstract

Because one-third of patients deteriorate after their admission to the emergency department, assessing the prognosis of COVID-19 patients is of great importance. However, to date, only lymphopenia and the partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio have been reported as partly predictive of COVID-19–related further deterioration, and their association has not been evaluated. We asked whether other key biomarkers of SARS-CoV-2 immunologic defects—increase in circulating immature granulocytes, loss of monocyte HLA-DR (mHLA-DR) expression, and monocyte differentiation blockade—could also predict further COVID-19 deterioration. A series of 284 consecutive COVID-19 patients, with the sole inclusion criterion of being an adult, were prospectively enrolled at emergency department admission (day 0) of 2 different hospitals: 1 for the exploratory cohort (180 patients) and 1 for the confirmatory cohort (104 patients). Deterioration was assessed over the next 7 days. Neither increased immature granulocyte levels nor monocyte differentiation blockade predicted patient worsening. Among more than 30 clinical, biological, and radiological parameters, the value of decreased P/F ratio and lymphopenia for prediction of further COVID-19 deterioration was strongly confirmed, and the loss of mHLA-DR was the only additional independent marker. Combined together in a simple OxyLymphoMono score, the 3 variables perfectly predicted patients who did not worsen and correctly predicted worsening in 59% of cases. By highlighting lymphocyte and monocyte defects as preceding COVID-19 deterioration, these results point on early immunosuppression in COVID-19 deterioration. Combining P/F ratio, lymphopenia, and loss of mHLA-DR together in a simple and robust score could offer a pragmatic method for COVID-19 patient stratification.Preceding COVID-19 deterioration, increase in low HLA-DR monocytes points on early COVID-19 immunosuppression and, with lymphopenia, is the only independent biological parameter predicting COVID-19 worsening.

Published
2024
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26. Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Author

Kamilia, Chtara, Regaieg, Kais, Baccouch, Najeh, Chelly, Hedi, Bahloul, Mabrouk, Bouaziz, Mounir, Jendoubi, Ali, Abbes, Ahmed, Belhaouane, Houda, Nasri, Oussama, Jenzri, Layla, Ghedira, Salma, Houissa, Mohamed, Belkadi, Kamal, Harti, Youness, Nsiri, Afak, Khaleq, Khalid, Hamoudi, Driss, Harrar, Rachid, Thieffry, Camille, Wallet, Frédéric, Parmentier-Decrucq, Erika, Favory, Raphaël, Mathieu, Daniel, Poissy, Julien, Lafon, Thomas, Vignon, Philippe, Begot, Emmanuelle, Appert, Alexandra, Hadj, Mathilde, Claverie, Paul, Matt, Morgan, Barraud, Olivier, François, Bruno, Jamoussi, Amira, Jazia, Amira Ben, Marhbène, Takoua, Lakhdhar, Dhouha, Khelil, Jalila Ben, Besbes, Mohamed, Goutay, Julien, Blazejewski, Caroline, Joly-Durand, Isabelle, Pirlet, Isabelle, Weillaert, Marie Pierre, Beague, Sebastien, Aziz, Soufi, Hafiane, Reda, Hattabi, Khalid, Bouhouri, Mohamed Aziz, Hammoudi, Driss, Fadil, Abdelaziz, Harrar, Rachid Al, Zerouali, Khalid, Medhioub, Fatma Kaaniche, Allela, Rania, Algia, Najla Ben, Cherif, Samar, Slaoui, Mohamed Taoufik, Boubia, Souhail, Hafiani, Y., Khaoudi, A., Cherkab, R., Elallam, W., Elkettani, C., Barrou, L., Ridaii, M., Mehdi, Rihi El, Schimpf, Caroline, Mizrahi, Assaf, Pilmis, Benoît, Le Monnier, Alban, Tiercelet, Kelly, Cherin, Mélanie, Bruel, Cédric, Philippart, Francois, Bailly, Sébastien, Lucet, Jc, Lepape, Alain, L’hériteau, François, Aupée, Martine, Bervas, Caroline, Boussat, Sandrine, Berger-Carbonne, Anne, Machut, Anaïs, Savey, Anne, Timsit, Jean-François, Razazi, Keyvan, Rosman, Jérémy, de Prost, Nicolas, Carteaux, Guillaume, Jansen, Chloe, Decousser, Jean Winoc, Brun-Buisson, Christian, Dessap, Armand Mekontso, M’rad, Aymen, Ouali, Zouhour, Barghouth, Manel, Kouatchet, Achille, Mahieu, Rafael, Weiss, Emmanuel, Schnell, David, Zahar, Jean-Ralph, Artiguenave, Margaux, Sophie, Paktoris-Papine, Espinasse, Florence, Sayed, Faten El, Dinh, Aurélien, Charron, Cyril, Geri, Guillaume, Vieillard-Baron, Antoine, Repessé, Xavier, Kallel, Hatem, Mayence, Claire, Houcke, Stéphanie, Guegueniat, Pascal, Hommel, Didier, Dhifaoui, Kaouther, Hajjej, Zied, Fatnassi, Amira, Sellami, Walid, Labbene, Iheb, Ferjani, Mustapha, Dachraoui, Fahmi, Nakkaa, Sabrine, M’ghirbi, Abdelwaheb, Adhieb, Ali, Braiek, Dhouha Ben, Hraiech, Kmar, Ousji, Ali, Ouanes, Islem, Zaineb, Hammouda, Abdallah, Saousen Ben, Ouanes-Besbes, Lamia, Abroug, Fekri, Klein, Simon, Miquet, Mattéo, Thouret, Jean-Marc, Peigne, Vincent, Daban, Jean-Louis, Boutonnet, Mathieu, Lenoir, Bernard, Merhbene, Takoua, Derreumaux, Celine, Seguin, Thierry, Conil, Jean-Marie, Kelway, Charlotte, Blasco, Valery, Nafati, Cyril, Harti, Karim, Reydellet, Laurent, Albanese, Jacques, Aicha, Narjess Ben, Meddeb, Khaoula, Khedher, Ahmed, Ayachi, Jihene, Fraj, Nesrine, Sma, Nesrine, Chouchene, Imed, Boussarsar, Mohamed, Yedder, Soumaya Ben, Samoud, Walid, Radhouene, Bousselmi, Mariem, Bousselmi, Ammar, Asma, Cheikh, Asma Ben, Lakhal, Hend Ben, Khelfa, Messaouda, Hamdaoui, Yamina, Bouafia, Nabiha, Trampont, Timothée, Daix, Thomas, Legarçon, Vincent, Karam, Henri Hani, Pichon, Nicolas, Essafi, Fatma, Foudhaili, Nasreddine, Thabet, Hafedh, Blel, Youssef, Brahmi, Nozha, Ezzouine, Hanane, Kerrous, Mahmoud, Haoui, Saad El, Ahdil, Soufiane, Benslama, Abdellatif, Abidi, Khalid, Dendane, Tarek, Oussama, Ssouni, Belayachi, Jihane, Madani, Naoufal, Abouqal, Redouane, Zeggwagh, Amine Ali, Ghadhoune, Hatem, Chaari, Anis, Jihene, Guissouma, Allouche, Hend, Trabelsi, Insaf, Brahmi, Habib, Samet, Mohamed, Ghord, Hatem El, Habiba, Ben Sik Ali, Hajer, Nouira, Tilouch, Najla, Yaakoubi, Sondes, Jaoued, Oussama, Gharbi, Rim, Hassen, Mohamed Fekih, Elatrous, Souheil, Arcizet, Julien, Leroy, Bertrand, Abdulmalack, Caroline, Renzullo, Catherine, Hamet, Maël, Doise, Jean-Marc, Coutet, Jérôme, Cheikh, Chaigar Mohammed, Quechar, Zakaria, Joris, Magalie, Beauport, Dimitri Titeca, Kontar, Loay, Lebon, Delphine, Gruson, Bérengère, Slama, Michel, Marolleau, Jean-Pierre, Maizel, Julien, Gorham, Julie, Ameye, Lieveke, Berghmans, Thierry, Paesmans, Marianne, Sculier, Jean-Paul, Meert, Anne-Pascale, Guillot, Max, Ledoux, Marie-Pierre, Braun, Thierry, Maestraggi, Quentin, Michard, Baptiste, Castelain, Vincent, Herbrecht, Raoul, Schneider, Francis, Couffin, Severine, Lobo, David, Mongardon, Nicolas, Dhonneur, Gilles, Mounier, Roman, Le Borgne, Pierrick, Couraud, Sophie, Herbrecht, Jean-Etienne, Boivin, Alexandra, Lefebvre, François, Bilbault, Pascal, Zelmat, Setti-Aouicha, Batouche, Djamila-Djahida, Mazour, Fatima, Chaffi, Belkacem, Benatta, Nadia, Sik, Ali Habiba, Talik, I., Perrier, Maxime, Gouteix, Eliane, Koubi, Claude, Escavy, Annabelle, Guilbaut, Victoria, Fosse, Jean-Philippe, Jazia, Rahma Ben, Abdelghani, Ahmed, Cungi, Pierre-Julien, Bordes, Julien, Nguyen, Cédric, Pierrou, Candice, Cruc, Maximilien, Benois, Alain, Duprez, Frédéric, Bonus, Thierry, Cuvelier, Grégory, Ollieuz, Sandra, Machayekhi, Sharam, Paciorkowski, Frédéric, Reychler, Gregory, Coudroy, Remi, Thille, Arnaud W., Drouot, Xavier, Diaz, Véronique, Meurice, Jean-Claude, Robert, René, Turki, Olfa, Ben, Hmida Chokri, Assefi, Mona, Deransy, Romain, Brisson, Hélène, Monsel, Antoine, Conti, Filomena, Scatton, Olivier, Langeron, Olivier, Ghezala, Hassen Ben, Snouda, Salah, Ben, Chiekh Imen, Kaddour, Moez, Armel, Anwar, Youness, Lafrikh, Abdelhak, Bensaid, Youssef, Miloudi, Najib, Al Harrar, Mustapha, Amouzoun, Noufel, Mtioui, Mohamed, Zamd, Salma, El Khayat, Ghizlane, Medkouri, Mohamed, Benghanam, Benyounes, Ramdani, Montini, Florent, Moschietto, Sébastien, Gregoire, Emilien, Claisse, Guillaume, Guiot, Julien, Morimont, Philippe, Krzesinski, Jean-Marie, Mariat, Christophe, Lambermont, Bernard, Cavalier, Etienne, Delanaye, Pierre, Benbernou, Soumia, Ilies, Sofiane, Azza, Abdelkader, Bouyacoub, Khalida, Louail, Meriem, Mokhtari-Djebli, Houria, Arrestier, Romain, Daviaud, Fabrice, Francois, Xavier Laborne, Brocas, Elsa, Choukroun, Gérald, Peñuelas, Oscar, Lorente, José-Angel, Cardinal-Fernandez, Pablo, Rodriguez, José-Maria, Aramburu, José-Antonio, Esteban, Andres, Frutos-Vivar, Fernando, Bitker, Laurent, Costes, Nicolas, Le Bars, Didier, Lavenne, Franck, Devouassoux, Mojgan, Richard, Jean-Christophe, Mechati, Malika, Gainnier, Marc, Papazian, Laurent, Guervilly, Christophe, Garnero, Aude, Arnal, Jean Michel, Roze, Hadrien, Richard, Jean Christophe, Repusseau, Benjamin, Dewitte, Antoine, Joannes-Boyau, Olivier, Ouattara, Alexandre, Harbouze, Nadia, Amine, A. M., Olandzobo, A. G., Herbland, Alexandre, Richard, Marie, Girard, Nicolas, Lambron, Lucile, Lesieur, Olivier, Wainschtein, Sarah, Hubert, Sidonie, Hugues, Albane, Tran, Marc, Bouillard, Philippe, Loteanu, Vlad, Leloup, Maxime, Laurent, Alexandra, Lheureux, Florent, Prestifilippo, Alessia, Cruz, Martin Delgado Maria, Romain, Rigal, Antonelli, Massimo, Blanch, Torra Lluis, Bonnetain, Franck, Grazzia-Bocci, Maria, Mancebo, Jordi, Samain, Emmanuel, Paul, Hebert, Capellier, Gilles, Zavgorodniaia, Taissa, Soichot, Marion, Malissin, Isabelle, Voicu, Sebastian, Garçon, Pierre, Goury, Antoine, Kerdjana, Lamia, Deye, Nicolas, Bourgogne, Emmanuel, Megarbane, Bruno, Mejri, Olfa, Hmida, Marwa Ben, Tannous, Salma, Chevillard, Lucie, Labat, Laurence, Risede, Patricia, Fredj, Hana, Léger, Maxime, Brunet, Marion, Le Roux, Gaël, Boels, David, Lerolle, Nicolas, Farah, Souaad, Amiel-Niemann, Hélène, Kubis, Nathalie, Declèves, Xavier, Peyraux, Nicoals, Baud, Frederic, Serafini, Micaela, Alvarez, Jean-Claude, Heinzelman, Annette, Jozwiak, Mathieu, Millasseau, Sandrine, Teboul, Jean-Louis, Alphonsine, Jean-Emmanuel, Depret, François, Richard, Nathalie, Attal, Pierre, Richard, Christian, Monnet, Xavier, Chemla, Denis, Jerbi, Salma, Khedhiri, Wafa, Necib, Hatem, Scarfo, Paolo, Chevalier, Charles, Piagnerelli, Michael, Lafont, Alexandre, Galy, Antoine, Mancia, Claire, Zerhouni, Amel, Tabeliouna, Kheira, Gaja, Ali, Hamrouni, Bassem, Malouch, Abir, Fourati, Sami, Messaoud, Rihab, Zarrouki, Youssef, Ziadi, Amra, Rhezali, Manal, Zouizra, Zahira, Boumzebra, Drissi, Samkaoui, Mohamed Abdennasser, Brunet, Jennifer, Canoville, Bertrand, Verrier, Pierre, Ivascau, Calin, Seguin, Amélie, Valette, Xavier, Du Cheyron, Damien, Daubin, Cedric, Bougouin, Wulfran, Aissaoui, Nadia, Lamhaut, Lionel, Jost, Daniel, Maupain, Carole, Beganton, Frankie, Bouglé, Adrien, Dumas, Florence, Marijon, Eloi, Jouven, Xavier, Cariou, Alain, Poirson, Florent, Chaput, Ulriikka, Beeken, Thomas, Maxime, Leclerc, Haikel, Oueslati, Vodovar, Dominique, Chelly, Jonathan, Marteau, Philippe, Chocron, Richard, Juvin, Philippe, Loeb, Thomas, Adnet, Frederic, Lecarpentier, Eric, Riviere, Antoine, De Cagny, Bertand, Soupison, Thierry, Privat, Elodie, Escutnaire, Joséphine, Dumont, Cyrielle, Baert, Valentine, Vilhelm, Christian, Hubert, Hervé, Leteurtre, Stéphane, Fresco, Marion, Bubenheim, Michael, Beduneau, Gaetan, Carpentier, Dorothée, Grange, Steven, Artaud-Macari, Elise, Misset, Benoit, Tamion, Fabienne, Girault, Christophe, Dumas, Guillaume, Chevret, Sylvie, Lemiale, Virginie, Mokart, Djamel, Mayaux, Julien, Pène, Frédéric, Nyunga, Martine, Perez, Pierre, Moreau, Anne-Sophie, Bruneel, Fabrice, Vincent, François, Klouche, Kada, Reignier, Jean, Rabbat, Antoine, Azoulay, Elie, Frat, Jean-Pierre, Ragot, Stéphanie, Constantin, Jean-Michel, Prat, Gwenael, Mercat, Alain, Boulain, Thierry, Demoule, Alexandre, Devaquet, Jérôme, Nseir, Saad, Charpentier, Julien, Argaud, Laurent, Beuret, Pascal, Ricard, Jean-Damien, Teiten, Christelle, Marjanovic, Nicolas, Palamin, Nicola, L’Her, Erwan, Bailly, Arthur, Boisramé-Helms, Julie, Champigneulle, Benoit, Kamel, Toufik, Mercier, Emmanuelle, Le Thuaut, Aurélie, Lascarrou, Jean-Baptiste, Rolle, Amélie, De Jong, Audrey, Chanques, Gérald, Jaber, Samir, Hariri, Geoffroy, Baudel, Jean-Luc, Dubée, Vincent, Preda, Gabriel, Bourcier, Simon, Joffre, Jeremie, Bigé, Naïke, Ait-Oufella, Hafid, Maury, Eric, Mater, Houda, Merdji, Hamid, Grimaldi, David, Rousseau, Christophe, Mira, Jean-Paul, Chiche, Jean-Daniel, Sedghiani, Ines, Benabderrahim, A., Hamdi, Dhekra, Jendoubi, Asma, Cherif, Mohamed Ali, Hechmi, Youssef Zied El, Zouheir, Jerbi, Bagate, François, Bousselmi, Radhwen, Schortgen, Frédérique, Asfar, Pierre, Guérot, Emmanuel, Fabien, Grelon, Anguel, Nadia, Sigismond, Lasocki, Matthieu, Henry-Lagarrigue, Gonzalez, Frédéric, François, Legay, Guitton, Christophe, Schenck, Maleka, Jean-Marc, Doise, Dreyfuss, Didier, Radermacher, Peter, Frère, Antoine, Martin-Lefèvre, Laurent, Colin, Gwenhaël, Fiancette, Maud, Henry-Laguarrigue, Matthieu, Lacherade, Jean-Claude, Lebert, Christine, Vinatier, Isabelle, Yehia, Aihem, Joret, Aurélie, Menunier-Beillard, Nicolas, Benzekri-Lefevre, Dalila, Desachy, Arnaud, Bellec, Fréderic, Plantefève, Gaëtan, Quenot, Jean-Pierre, Meziani, Ferhat, Tavernier, Elsa, Ehrmann, Stephan, Chudeau, Nicolas, Raveau, Tommy, Moal, Valérie, Houillier, Pascal, Rouve, Emmanuelle, Lakhal, Karim, Gandonnière, Charlotte Salmon, Jouan, Youenn, Bodet-Contentin, Laetitia, Balmier, Adrien, Messika, Jonathan, De Montmollin, Etienne, Pouyet, Victorine, Sztrymf, Benjamin, Thiagarajah, Abirami, Roux, Damien, De Chambrun, Marc Pineton, Luyt, Charles-Edouard, Beloncle, François, Zapella, Nathalie, Ledochowsky, Stanislas, Terzi, Nicolas, Mazou, Jean-Marc, Sonneville, Romain, Paulus, Sylvie, Fedun, Yannick, Landais, Mickael, Raphalen, Jean-Herlé, Combes, Alain, Amoura, Zahir, Jacquemin, Aemilia, Guerrero, Felipe, Marcheix, Bertrand, Hernandez, Nicolas, Fourcade, Olivier, Georges, Bernard, Delmas, Clément, Makoudi, Sarah, Genton, Audrey, Bernard, Rémy, Lebreton, Guillaume, Amour, Julien, Mazet, Charlotte, Bounes, Fanny, Murat, Gurbuz, Cronier, Laure, Robin, Guillaume, Biendel, Caroline, Silva, Stein, Boubeche, Samia, Abriou, Caroline, Wurtz, Véronique, Scherrer, Vincent, Rey, Nathalie, Gastaldi, Gioia, Veber, Benoit, Doguet, Fabien, Gay, Arnaud, Dureuil, Bertrand, Besnier, Emmanuel, Rouget, Antoine, Gantois, Guillaume, Magalhaes, Eric, Wanono, Ruben, Smonig, Roland, Lermuzeaux, Mathilde, Lebut, Jordane, Olivier, Andremont, Dupuis, Claire, Radjou, Aguila, Mourvillier, Bruno, Neuville, Mathilde, D’ortho, Marie Pia, Bouadma, Lila, Rouvel-Tallec, Anny, Rudler, Marika, Weiss, Nicolas, Perlbarg, Vincent, Galanaud, Damien, Thabut, Dominique, Rachdi, Emna, Mhamdi, Ghada, Trifi, Ahlem, Abdelmalek, Rim, Abdellatif, Sami, Daly, Foued, Nasri, Rochdi, Tiouiri, Hanene, Lakhal, Salah Ben, Rousseau, Geoffroy, Asmolov, Romain, Grammatico-Guillon, Leslie, Auvet, Adrien, Laribi, Said, Garot, Denis, Dequin, Pierre François, Guillon, Antoine, Fergé, Jean-Louis, Abgrall, Gwénolé, Hinault, Ronan, Vally, Shazima, Roze, Benoit, Chaplain, Agathe, Chabartier, Cyrille, Savidan, Anne-Charlotte, Marie, Sabia, Cabie, Andre, Resiere, Dabor, Valentino, Ruddy, Mehdaoui, Hossein, Benarous, Lucas, Soda-Diop, Marième, Bouzana, Fouad, Perrin, Gilles, Bourenne, Jeremy, Eon, Béatrice, Lambert, Dominique, Trebuchon, Agnes, Poncelet, Géraldine, Le Bourgeois, Fleur, Michael, Levy, Camille, Guillot, Naudin, Jérôme, Deho, Anna, Dauger, Stéphane, Sauthier, Michaël, Bergeron-Gallant, Krystale, Emeriaud, Guillaume, Jouvet, Philippe, Tiebergien, Nicolas, Jacquet-Lagrèze, Matthias, Fellahi, Jean-Luc, Baudin, Florent, Essouri, Sandrine, Javouhey, Etienne, Guérin, Claude, Lampin, Marie, Mamouri, Ouardia, Devos, Patrick, Karaca-Altintas, Yasemin, Vinchon, Matthieu, Brossier, David, Eltaani, Redha, Teyssedre, Sonia, Sabine, Meyet, Bouchut, Jean-Christophe, Peguet, Olivier, Petitdemange, Lucie, Guilbert, Anne Sophie, Aoul, Nabil Tabet, Addou, Zakaria, Aouffen, Nabil, Anas, Benqqa, Kalouch, Samira, Yaqini, Khalid, Chlilek, Aziz, Abdou, Rchi, Gravellier, Perrine, Chantreuil, Julie, Travers, Nadine, Listrat, Antoine, Le Reun, Claire, Favrais, Geraldine, Coppere, Zoe, Blanot, Stéphane, Montmayeur, Juliette, Bronchard, Régis, Rolando, Stephane, Orliaguet, Gilles, Leger, Pierre-Louis, Rambaud, Jérôme, Thueux, Emilie, De Larrard, Alexandra, Berthelot, Véronique, Denot, Julien, Reymond, Marie, Amblard, Alain, Morin-Zorman, Sarah, Lengliné, Etienne, Pichereau, Claire, Mariotte, Eric, Emmanuel, Canet, Poujade, Julien, Trumpff, Guillaume, Janssen-Langenstein, Ralf, Harlay, Marie-Line, Zaid, Noorah, Ait-Ammar, Nawel, Bonnal, Christine, Merle, Jean-Claude, Botterel, Francoise, Levesque, Eric, Riad, Zakaria, Mezidi, Mehdi, Yonis, Hodane, Aublanc, Mylène, Perinel-Ragey, Sophie, Lissonde, Floriane, Louf-Durier, Aurore, Tapponnier, Romain, Louis, Bruno, Forel, Jean-Marie, Bisbal, Magali, Lehingue, Samuel, Rambaud, Romain, Adda, Mélanie, Hraiech, Sami, Marchi, Elisa, Roch, Antoine, Guerin, Vincent, Rozencwajg, Sacha, Schmidt, Matthieu, Hekimian, Guillaume, Bréchot, Nicolas, Trouillet, Jean Louis, Besset, Sébastien, Franchineau, Guillaume, Nieszkowska, Ania, Pascal, Leprince, Loiselle, Maud, Sarah, Chemam, Laurence, Dangers, Guillemette, Thomas, Jacquens, Alice, Kerever, Sebastien, Guidet, Bertrand, Aegerter, Philippe, Das, Vincent, Fartoukh, Muriel, Hayon, Jan, Desmard, Mathieu, Fulgencio, Jean-Pierre, Zuber, Benjamin, Soufi, A., Khaleq, K., Hamoudi, D., Garret, Charlotte, Peron, Matthieu, Coron, Emmanuel, Bretonnière, Cédric, Audureau, Etienne, Audrey, Winters, Christophe, Duvoux, Christian, Jacquelinet, Daniel, Azoulay, Cyrille, Feray, Aissaoui, Wissal, Rghioui, Kawtar, Haddad, Wafae, Barrou, Houcine, Carteaux-Taeib, Anna, Lupinacci, Renato, Manceau, Gilles, Jeune, Florence, Tresallet, Christophe, Habacha, Sahar, Fathallah, Ines, Zoubli, Aymen, Aloui, Rafaa, Kouraichi, Nadia, Jouet, Emilie, Badin, Julie, Fermier, Brice, Feller, Marc, Serie, Mathieu, Pillot, Jérôme, Marie, William, Gisbert-Mora, Chloé, Vinclair, Camille, Lesbordes, Pierre, Mathieu, Pascal, De Brabant, Fabienne, Muller, Emmanuel, Robaux, Marie-Aline, Giabicani, Mikhael, Marchalot, Antoine, Gelinotte, Stéphanie, Declercq, Pierre Louis, Eraldi, Jean-Pierre, Bougerol, François, Meunier-Beillard, Nicolas, Devilliers, Hervé, Rigaud, Jean-Philippe, Verrière, Camille, Ardisson, Fanny, Kentish-Barnes, Nancy, Jacq, Gwenaëlle, Chermak, Akli, Lautrette, Alexandre, Legrand, Matthieu, Soummer, Alexis, Thiery, Guillaume, Cottereau, Alice, Canet, Emmanuel, Caujolle, Marie, Allyn, Jérôme, Valance, Dorothée, Brulliard, Caroline, Martinet, Olivier, Jabot, Julien, Gallas, Thomas, Vandroux, David, Allou, Nicolas, Durand, Arthur, Nevière, Rémi, Delguste, Florian, Boulanger, Eric, Preau, Sebastien, Martin, Ruste, Cochet, Hélène, Ponthus, Jean Pierre, Amilien, Virginie, Tchir, Martial, Barsam, Elise, Ayoub, Mohsen, Georger, Jean Francois, Guillame, Izaute, Assaraf, Julie, Tripon, Simona, Mallet, Maxime, Barbara, Guilaume, Louis, Guillaume, Gaudry, Stéphane, Barbarot, Nicolas, Jamet, Angéline, Outin, Hervé, Gibot, Sébastien, Bollaert, Pierre-Edouard, Holleville, Mathilde, Legriel, Stéphane, Chateauneuf, Anne Laure, Cavelot, Sébastien, Moyer, Jean-Denis, Bedos, Jean Pierre, Merle, Philippe, Laine, Aurelie, Natalie, De Sa, Cornuault, Mathieu, Libot, Jérome, Asehnoune, Karim, Rozec, Bertrand, Dantal, Jacques, Videcoq, Michel, Degroote, Thècle, Jaillette, Emmanuelle, Zerimech, Farid, Malika, Balduyck, Llitjos, Jean-François, Amara, Marlène, Lacave, Guillaume, Pangon, Béatrice, Mavinga, José, Makunza, Joseph Nsiala, Mafuta, M. E., Yanga, Yves, Eric, Amisi, Ilunga, Jp, Kilembe, Ma, Alby-Laurent, Fanny, Toubiana, Julie, Mokline, Amel, Laajili, Achraf, Amri, Helmi, Rahmani, Imene, Mensi, Nidhal, Gharsallah, Lazheri, Tlaili, Sofiene, Gasri, Bahija, Hammouda, Rym, Messadi, Amen Allah, Allain, Pierre-Antoine, Gault, Nathallie, Paugam-Burtz, Catherine, Foucrier, Arnaud, Chatbri, Bassem, Bourbiaa, Yousra, Thabet, Lamia, Neuschwander, Arthur, Vincent, Looten, Beck, Jennifer, Vibol, Chhor, Amelie, Yavchitz, Resche-Rigon, Matthieu, Pirracchio, Jean MantzRomain, Bureau, Côme, Decavèle, Maxens, Campion, Sébastien, Ainsouya, Roukia, Niérat, Marie-Cécile, Prodanovic, Hélène, Raux, Mathieu, Similowski, Thomas, Dubé, Bruno-Pierre, Demiri, Suela, Dres, Martin, May, Faten, Quintard, Hervé, Kounis, Ilias, Saliba, Faouzi, André, Stephane, Boudon, Marc, Ichai, Philippe, Younes, Aline, Nakad, Lionel, Coilly, Audrey, Antonini, Teresa, Sobesky, Rodolphe, De Martin, Eleonora, Samuel, Didier, Hubert, Noemie, Nay, Mai-Anh, Auchabie, Johann, Giraudeau, Bruno, Jean, Reignier, Darmon, Michaël, Ruckly, Stephane, Garrouste-Orgeas, Maïté, Gratia, Elisabeth, Goldgran-Toledano, Dany, Jamali, Samir, Dumenil, Anne Sylvie, Schwebel, Carole, Brisard, Laurent, Bizouarn, Philippe, Lepoivre, Thierry, Nicolet, Johanna, Rigal, Jean Christophe, Roussel, Jean Christian, Cheurfa, Cherifa, Abily, Julien, Lescot, Thomas, Page, Isaline, Warnier, Stéphanie, Nys, Monique, Rousseau, Anne-Françoise, Damas, Pierre, Uhel, Fabrice, Lesouhaitier, Mathieu, Grégoire, Murielle, Gaudriot, Baptiste, Gacouin, Arnaud, Le Tulzo, Yves, Flecher, Erwan, Tarte, Karin, Tadié, Jean-Marc, Georges, Quentin, Soares, M., Jeon, Kyeongman, Oeyen, Sandra, Rhee, Chin Kook, Gruber, Pascale, Ostermann, Marlies, Hill, Quentin, Depuydt, Peter, Ferra, Christelle, Muller, Alice, Aurelie, Bourmaud, Niles, Christopher, Herbert, Fabien, Pied, Sylviane, Loridant, Séverine, François, Nadine, Bignon, Anne, Sendid, Boualem, Lemaitre, Caroline, Dupre, Celine, Zayene, Aymen, Portier, Lucie, De Freitas Caires, Nathalie, Lassalle, Philippe, Le Neindre, Aymeric, Selot, Pascal, Ferreiro, Daniel, Bonarek, Maria, Henriot, Stépahen, Rodriguez, Julie, Taddei, Mara, Di Bari, Mauro, Hickmann, Cheryl, Castanares-Zapatero, Diego, Deldicque, Louise, Van Den Bergh, Peter, Caty, Gilles, Roeseler, Jean, Francaux, Marc, Laterre, Pierre-François, Dupuis, Bastien, Machayeckhi, Sharam, Sarfati, Celine, Moore, Alex, Mendialdua, Paula, Rodet, Emilie, Pilorge, Catherine, Stephan, Francois, Rezaiguia-Delclaux, Saida, Dugernier, Jonathan, Hesse, Michel, Jumetz, Thibaud, Bialais, Emilie, Depoortere, Virginie, Michotte, Jean Bernard, Wittebole, Xavier, Jamar, François, REA‑RAISIN Studygroup, OUTCOMEREA study group, Sudden Death Expertise Center, for the HYPER2S Investigators and REVA research network, Clinical Research in Intensive Care and Sepsis (CRICS network), Cubrea network, and Brain Liver Pitié-Salpêtrière Study Group (BLIPS)

Published
2017
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29. Demultiplexing Ig Repertoires by Parallel mRNA/DNA Sequencing Shows Major Differential Alterations in Severe COVID-19

Author

Pascal, Virginie, primary, Dupont, Marine, additional, de Rouault, Paco, additional, Rizzo, David, additional, Rossille, Delphine, additional, Jeannet, Robin, additional, Daix, Thomas, additional, François, Bruno, additional, Monneret, Guillaume, additional, Venet, Fabienne, additional, Ferrant, Juliette, additional, Roussel, Mikael, additional, Reizine, Florian, additional, Le Souhaitier, Mathieu, additional, Tadié, Jean-Marc, additional, Tarte, Karin, additional, Feuillard, Jean, additional, and Cogné, Michel, additional

Published
2022
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30. Could daily changes in respiratory microbiota help predicting early Staphylococcus aureus ventilator-associated pneumonia?

Author

Meyer, Sylvain, Gaïa, Nadia, Lazarevic, Vladimir, Schrenzel, Jacques, François, Bruno, Barraud, Olivier, Daix, Thomas, Chainier, Delphine, Ploy, Marie-Cécile, and Vignon, Philippe

Subjects
VENTILATOR-associated pneumonia, STAPHYLOCOCCUS aureus, HUMAN microbiota, KLEBSIELLA pneumoniae
Abstract

We hypothesized post hoc that patients who develop I Staphylococcus aureus i VAP might exhibit modified respiratory microbiota during mechanical ventilation (MV) when compared to patients without VAP. Keywords: Ventilator-associated pneumonia; Respiratory microbiota; Staphylococcus aureus; Anaerobes EN Ventilator-associated pneumonia Respiratory microbiota Staphylococcus aureus Anaerobes 1 3 3 06/26/23 20230623 NES 230623 Supplementary Information The online version contains supplementary material available at https://doi.org/10.1186/s40635-023-00521-7. [Extracted from the article]

Published
2023
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33. Additional file 1 of Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Author

Pugin, Jérôme, Daix, Thomas, Pagani, Jean-Luc, Morri, Davide, Giacomucci, Angelo, Pierre-François Dequin, Guitton, Christophe, Yok-Ai Que, Zani, Gianluca, Brealey, David, Lepape, Alain, Creagh-Brown, Ben, Wyncoll, Duncan, Silengo, Daniela, Irincheeva, Irina, Girard, Laurie, Rebeaud, Fabien, Maerki, Iwan, Eggimann, Philippe, and François, Bruno

Abstract

Additional file 1: Table 1. (a) Study participating centers and (b) site recruitment. Table 2. Inclusion and exclusion criteria applied for patient recruitment. Table 3. Estimated coefficients of mixed-effects models for testing the consecutive increases in pancreatic stone protein, procalcitonin, and C-reactive protein levels serving as response variables. Table 4. Estimates for the mixed-effects models for which the results are reported in Table 3.

Published
2021
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34. Additional file 2 of Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Author

Pugin, Jérôme, Daix, Thomas, Pagani, Jean-Luc, Morri, Davide, Giacomucci, Angelo, Pierre-François Dequin, Guitton, Christophe, Yok-Ai Que, Zani, Gianluca, Brealey, David, Lepape, Alain, Creagh-Brown, Ben, Wyncoll, Duncan, Silengo, Daniela, Irincheeva, Irina, Girard, Laurie, Rebeaud, Fabien, Maerki, Iwan, Eggimann, Philippe, and François, Bruno

Abstract

Additional file 2: Figure 1. The abioSCOPE® device and its in vitro diagnostic CAPSULE pancreatic stone protein.

Published
2021
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36. Additional file 3 of Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Author

Pugin, Jérôme, Daix, Thomas, Pagani, Jean-Luc, Morri, Davide, Giacomucci, Angelo, Pierre-François Dequin, Guitton, Christophe, Yok-Ai Que, Zani, Gianluca, Brealey, David, Lepape, Alain, Creagh-Brown, Ben, Wyncoll, Duncan, Silengo, Daniela, Irincheeva, Irina, Girard, Laurie, Rebeaud, Fabien, Maerki, Iwan, Eggimann, Philippe, and François, Bruno

Abstract

Additional file 3: Figure 2. ROC curves for the diagnosis of sepsis at the time sepsis was clinically diagnosed by the EAC.

Published
2021
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37. Persistent Lymphocytopenia Does Not Increase Nosocomial Infection Risk in the ICU

Author

Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, CDL Arcadia, Circulatory Health, Epi Infectieziekten, MMB, Infection & Immunity, DVF Medisch, Varkila, Meri R J, Marrec, Louise, Daix, Thomas, Hoefer, Imo E, Haitjema, Saskia, Bonten, Marc J M, Cremer, Olaf L, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, CDL Arcadia, Circulatory Health, Epi Infectieziekten, MMB, Infection & Immunity, DVF Medisch, Varkila, Meri R J, Marrec, Louise, Daix, Thomas, Hoefer, Imo E, Haitjema, Saskia, Bonten, Marc J M, and Cremer, Olaf L

Published
2021

38. Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients

Author

Jouan, Youenn, Guillon, Antoine, Gonzalez, Loïc, Perez, Yonatan, Boisseau, Chloé, Ehrmann, Stephan, Ferreira, Marion, Daix, Thomas, Jeannet, Robin, François, Bruno, Dequin, Pierre-François, Si-Tahar, Mustapha, Baranek, Thomas, Paget, Christophe, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Tours (UT), Hôpital Dupuytren [CHU Limoges], Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours, PAGET, Christophe, and Gonzalez, Loïc

Subjects
Antigens, Differentiation, T-Lymphocyte, Male, T-Lymphocytes, [SDV]Life Sciences [q-bio], Innate Immunity and Inflammation, Immunology, Pneumonia, Viral, Severity of Illness Index, Mucosal-Associated Invariant T Cells, Infectious Disease and Host Defense, Betacoronavirus, Antigens, CD, Immunology and Allergy, Humans, Lectins, C-Type, Prospective Studies, Pandemics, Cells, Cultured, Aged, Inflammation, Respiratory Distress Syndrome, SARS-CoV-2, Brief Definitive Report, COVID-19, Receptors, Antigen, T-Cell, gamma-delta, Mucosal Immunology, Middle Aged, Prognosis, [SDV] Life Sciences [q-bio], Phenotype, Cytokines, Natural Killer T-Cells, Female, Coronavirus Infections
Abstract

This study reveals profound alteration in biology of blood unconventional T cells (MAIT, iNKT, and γδT) in severe COVID-19. Highly activated MAIT cells are found in abundance in the airways of mechanically ventilated patients. Activation levels of MAIT/iNKT cells at admission positively correlate with clinical improvement., COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS–CoV-2–driven ARDS., Graphical Abstract

Published
2020

41. Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

Author

Blet, Alice, De Roquetaillade, Charles, Hartmann, Oliver, Struck, Joachim, Mebazaa, Alexandre, Chousterman, Benjamin Glenn, Laterre, Pierre François, Berghe, Caroline, Dujardin, Marie France, Renard, Suzanne, Wittebole, Xavier, Collienne, Christine, Zapatero, Diego Castanares, Dugernier, Thierry, Vinetti, Marco, De Schryver, Nicolas, Thirifays, Anne, Mairesse, Jacques, Huberlant, Vincent, Petre, Hélène, Buelens, Isabelle, Henin, Pierre, Trine, Hugues, Laurent, Yves, Sébastien, Loix, Geukens, Paul, Kehl, Laurent, François, Bruno, Vignon, Philippe, Pichon, Nicolas, Begot, Emmanuelle, Fedou, Anne Laure, Chapellas, Catherine, Galy, Antoine, Rodier, Nicolas, Baudrillart, Ludmilla, Nouaille, Michelle, Laleu, Séverine, Mancia, Claire, Daix, Thomas, Bourzeix, Paul, Herafa, Isabelle, Duchambon, Anne Aurore, Lascarrou, Jean Baptiste, Fiancette, Maud, Colin, Gwenhael, Henry-Lagarrigue, Matthieu, Lacherade, Jean Claude, Lebert, Christine, Martin-Levfèvre, Laurent, Vinatier, Isabelle, Yehia, Aihem, Bachoumas, Konstantinos, Joret, Aurélie, Reignier, Jean, Rousseau, Cécille, Maquigneau, Natacha, Alcourt, Yolaine, Zinzonni, Vanessa Erragne, Deschamps, Angélique, Robert, Angelina, Mercier, Emmanuelle, Simeon-Vieules, Véronique, Aubrey, Aurélie, Mabilat, Christine, Garot, Denis, Ehrmann, Stephan, Legras, Annick, Jouan, Youenn, Dequin, Pierre François, Guillon, Antoine, Bodet-Contentin, Laetitia, Rouve, Emmannuelle, Salmon, Charlotte, Brick, Lysiane, Massat, Stéphanie, Desachy, Arnaud, Fally, Marie Anne, Robin, Laurence, Cracco, Christophe, Lafon, Charles, Calvat, Sylvie, Rouleau, Stéphane, Schnell, David, Lasocki, Sigismond, Fesard, Philippe, Leblanc, Damien, Bouhours, Guillaume, Chassier, Claire, Conte, Mathieu, Gaillard, Thomas, Denou, Floriane, Kerymel, Mathieu, Guyon, Marion, Loiez, Anthéa, Lebreton, Stéphanie, Meziani, Ferhat, Allam, Hayat, Chenaf, Samir, Rahmani, Hassène, Heenen, Sarah, Kummerlen, Christine, Delabranche, Xavier, Boivin, Alexandra, Clere-Jehl, Raphaël, Rabouël, Yannick, Pottecher, Julien, Bayer, Sophie, Metzger, Catherine, Hecketsweiler, Stéphane, Ludes, Pierre Olivier, Besancenot, Hortense, Dhif, Nadia, Freys, Guy, Lessinger, Jean Marc, Launoy, Anne, Ruimy, Aude, Meyer, Alain, Szozot, M., Deye, Nicolas, Gayat, Etienne, Fournier, Marie Céline, Abroug, Sarra, Louadah, Badr, Feliot, Elodie, Voicu, Sebastian, Malissin, Isabelle, Megarbane, Bruno, Manivet, Philippe, Victori, Gardianot, Kelly, Da Silva, La Foucher, Béatrice, Pierre, Valérie, Kerdjana, Lamia, Beeken, Thomas, Goury, Antoine, Garcon, Pierre, Gaugain, Samuel, Huot, Benjamin, Barthelemy, Romain, Soyer, Benjamin, Jacob, Laurent, Legrand, Matthieu, Fourniar, Marie Céline, Bonnet, Francine, Legall, Chloé, Oueslati, Haikel, Cupaciu, Alexandru, Manivat, Philippe, Louadeh, Badr, Sonneville, Romain, Letrou, Sophie, Bouadma, Lila, Mourvillier, Bruno, Deiler, Véronique, Magalhaes, Eric, Neuville, Mathilde, Timsit, Jean François, Radjou, Aguila, Gaudry, Stéphane, Dubief, Emeline, Messika, Jonathan, La Combe, Béatrice, Roux, Damien, Berquier, Guillaume, Laissi, Mohamed, Ricard, Jean Damien, Constantin, Jean Michel, Perbet, Sebastien, Delmas, Julie, Pascal, Julien, Cayot, Sophie, Guerin, Renaud, Jabaudon, Matthieu, Roszyk, Laurence, Rolhion, Christine, Bourdier, Justine, Lematte, Mathilde, Gouhier, Charlène, Verlhac, Camille, Godet, Thomas, Radji, Sophiano, Caumon, Elodie, Thibault, Sandrine, Marx, Nikolaus, Schuerholz, Tobias, Pezechk, Jessica, Feld, Florian, Brülls, Christian, Beeker, Thorben, Simon, Tim Philipp, Deisz, Robert, Schindler, Achim, Meier, Bianca, Janisch, Thorsten, Hohn, Andreas, Schedler, Dirk, Wetsch, Wolfgang, Schröder, Daniel, Meier-Hellmann, Andreas, Lucht, Alexander, Henker, Robert, Römmer, Magdalena, Meinig, Torsten, Zacharowski, Kai D., Meybohm, Patrick, Lindau, Simone, Mutlak, Haitham, Kluge, Stefan, Ringeis, Grit, Füllekrug, Birgit, Singer, Brigitte, Nierhaus, Axel, Bangert, Katrin, De Heer, Geraldine, Frings, Daniel, Fuhrmann, Valentin, Müller, Jakob, Schreiber, Jörg, Sensen, Barbara, Siedler, Stephanie, Siewecke, Annekatrin, Söffker, Gerold, Wichmann, Dominic, Kerinn, Mélanie, Jaschinski, Ulrich, Kreuser, Ilse, Zanquila, Marlene, Kortgen, Andreas, Bloos, Frank, Gonnert, Falk, Thomas-Rüddel, Daniel, Haucke, Anja, Kolanos, Steffi, Kohlberg, Karina Knuhr, Bloos, Petra, Schwope, Katrin, Di Somma, Salvatore, Rossella, Marino, Russo, Veronica, Simona, Santarelli, Bartoli, Christopher, Navarin, Sylvia, Bongiovanni, Cristina, Orru, Michela, Quatrocchi, Daniela, Zoccoli, Giada, Varchetta, Antonella, Antonelli, Massimo, De Pascale, Gennaro, Vallecoccia, Maria Sole, Cutuli, Salvatore Lucio, Digravio, Valentina, Quattrochi, Daniela, D'Arrigo, Sonia, Leone, Filippo Elvino, Beishuizen, Bert, Rinket, Martin, Border, Natalie, Bos-Burgmeijer, Mariska, Braad, Astrid, Papendorp, S., Vermeijden, J., Pickkers, Peter, Van De A, Marieke, Van Wezel, Helen, Heunks, Leo, Bordar, Natalie, Luijten-Arts, Chantal, Hoedemaekers, Astrid, Van Der Hoeven, Hans, Roovers, Noortje, Hemelaar, Pleun, Intensive care medicine, ACS - Pulmonary hypertension & thrombosis, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, and UCL - (SLuc) Service de soins intensifs

Subjects
Male, medicine.medical_specialty, Multiple Organ Failure, MEDLINE, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Critical Care and Intensive Care Medicine, Sepsis, 03 medical and health sciences, Adrenomedullin, 0302 clinical medicine, Belgium, Germany, medicine, Research Letter, Humans, Lactic Acid, Hospital Mortality, Prospective Studies, Prospective cohort study, Aged, Netherlands, Proportional Hazards Models, Chi-Square Distribution, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, lcsh:RC86-88.9, Length of Stay, Middle Aged, medicine.disease, Prognosis, Shock, Septic, Survival Analysis, 3. Good health, Hospitalization, Patient Outcome Assessment, Intensive Care Units, 030228 respiratory system, Italy, Shock (circulatory), Emergency medicine, Female, France, medicine.symptom, business, Biomarkers
Abstract

Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock.Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8).AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial.ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.

Published
2020

42. Immunotherapies for COVID-19: lessons learned from sepsis.

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Remy, Kenneth E, Brakenridge, Scott C, Francois, Bruno, Daix, Thomas, Deutschman, Clifford S, Monneret, Guillaume, Jeannet, Robin, Laterre, Pierre-François, Hotchkiss, Richard S, Moldawer, Lyle L, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Remy, Kenneth E, Brakenridge, Scott C, Francois, Bruno, Daix, Thomas, Deutschman, Clifford S, Monneret, Guillaume, Jeannet, Robin, Laterre, Pierre-François, Hotchkiss, Richard S, and Moldawer, Lyle L

Abstract

Therapeutic approaches to mitigate the severe acute lung injury associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have rapidly entered clinical trials primarily on anecdotal observations and few clinical studies. Along with the clinical symptoms related to viral invasion, the reported molecular response known as the cytokine storm has attracted the greatest attention, in both the scientific and the lay press, as a cause of organ injury. [...]

Published
2020

43. New Agents in Development for Sepsis: Any Reason for Hope?

Author

UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Vignon, Philippe, Laterre, Pierre-François, Daix, Thomas, François, Bruno, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, Vignon, Philippe, Laterre, Pierre-François, Daix, Thomas, and François, Bruno

Abstract

Sepsis is a syndrome which is defined as a dysregulated host response to infection leading to organ failure. Since it remains one of the leading causes of mortality worldwide, numerous drug candidates have already been tested, and continue to be developed, as potential adjunct therapies. Despite convincing mechanisms of action and robust pre-clinical data, almost all drug candidates in the field of sepsis have failed to demonstrate clinical efficacy in the past two decades. Accordingly, the development of new sepsis drugs has markedly decreased in the past few years. Nevertheless, thanks to a better understanding of sepsis pathophysiology and pathways, new promising drug candidates are currently being developed. Instead of a unique sepsis profile as initially suspected, various phenotypes have been characterised. This has resulted in the identification of multiple targets for new drugs together with relevant biomarkers, and a better understanding of the most appropriate time to intervention. Within the entire sepsis drugs portfolio, those targeting the immune response are probably the most promising. Monoclonal antibodies targeting either cytokines or infectious agents are undoubtedly part of the potential successful therapeutic classes to come.

Published
2020

44. Serial Measurement of Pancreatic Stone Protein for the Early Detection of Sepsis in Intensive Care Unit Patients: A Prospective Multicentric Study

Author

Pugin, Jérôme, primary, Daix, Thomas, additional, Pagani, Jean-Luc, additional, Morri, Davide, additional, Giacomucci, Angelo, additional, Dequin, Pierre-François, additional, Guitton, Christophe, additional, Que, Yok-Ai, additional, Zani, Gianluca, additional, Brealey, David, additional, Lepape, Alain, additional, Creagh-Brown, Ben, additional, Wyncoll, Duncan, additional, Silengo, Daniela, additional, Irincheeva, Irina, additional, Girard, Laurie, additional, Rebeaud, Fabien, additional, Maerki, Iwan, additional, Eggimann, Philippe, additional, and François, Bruno, additional

Published
2021
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46. Bicentric evaluation of stabilizing sampling tubes for assessment of monocyte HLA‐DRexpression in clinical samples

Author

Hamada, Sarah, Jeannet, Robin, Gossez, Morgane, Cour, Martin, Argaud, Laurent, Francois, Bruno, Daix, Thomas, Venet, Fabienne, and Monneret, Guillaume

Abstract

Diminished expression of human leukocyte antigen DR on circulating monocytes (mHLA‐DR), measured by standardized flow cytometry procedure, is a reliable indicator of immunosuppression in severely injured intensive care unit patients. As such, it is used as stratification criteria in clinical trials evaluating novel immunostimulating therapies. Preanalytical constraints relative to the short delay between blood sampling and flow cytometry staining have nevertheless limited its use in multicentric studies. The objective of the present work was to compare mHLA‐DR expression between whole blood samples simultaneously drawn in EDTA or Cyto‐Chex BCT tubes. In two university hospitals, mHLA‐DR was assessed in fresh whole blood from septic patients (n= 12) and healthy donors (n= 6) simultaneously sampled on EDTA and Cyto‐Chex BCT tubes. Staining was performed immediately after sampling and after blood storage at room temperature. We confirmed that samples collected in Cyto‐Chex tube had substantially enhanced stability for mHLA‐DR results (48–72 h) over those collected in EDTA. On baseline values, despite good correlation between tubes (r= 0.98, p< 0.001), mHLA‐DR expression was systematically lower with Cyto‐Chex BCT. The present reports confirms the potential of Cyto‐Chex BCT tubes to stabilize mHLA‐DR expression before staining and extends the work of Quadrini et al. [Cytometry B 2021;100:103‐114]. In centers without rapid access to flow cytometry facilities, it enables to tolerate delays in mHLA‐DR staining. However, a 30% gap exists between results obtained with EDTA and Cyto‐Chex BCT tubes. As current thresholds for clinical decisions were obtained with EDTA samples, further studies are needed to confirm clinical thresholds with Cyto‐Chex BCT tubes.

Published
2022
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48. Functional alteration of innate T cells in critically ill Covid-19 patients

Author

Jouan, Youenn, primary, Guillon, Antoine, additional, Gonzalez, Loïc, additional, Perez, Yonatan, additional, Ehrmann, Stephan, additional, Ferreira, Marion, additional, Daix, Thomas, additional, Jeannet, Robin, additional, François, Bruno, additional, Dequin, Pierre-François, additional, Si-Tahar, Mustapha, additional, Baranek, Thomas, additional, and Paget, Christophe, additional

Published
2020
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50. Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest

Author

François, Bruno, primary, Cariou, Alain, additional, Clere-Jehl, Raphaël, additional, Dequin, Pierre-François, additional, Renon-Carron, Françoise, additional, Daix, Thomas, additional, Guitton, Christophe, additional, Deye, Nicolas, additional, Legriel, Stéphane, additional, Plantefève, Gaëtan, additional, Quenot, Jean-Pierre, additional, Desachy, Arnaud, additional, Kamel, Toufik, additional, Bedon-Carte, Sandrine, additional, Diehl, Jean-Luc, additional, Chudeau, Nicolas, additional, Karam, Elias, additional, Durand-Zaleski, Isabelle, additional, Giraudeau, Bruno, additional, Vignon, Philippe, additional, and Le Gouge, Amélie, additional

Published
2019
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