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1. A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma.

Author

Anna Minchom, Daisy Mak, Ranga Gunapala, David Walder, Rajiv Kumar, Nadia Yousaf, Andrew Hodgkiss, Jaishree Bhosle, Sanjay Popat, and Mary E R O'Brien

Subjects
Medicine, Science
Abstract

ObjectivesVitamin supplementation reduces pemetrexed toxicity. Raised plasma homocysteine reflects deficiency in vitamin B12 and folate, and is suppressed by supplementation. This observational study of 112 patients receiving pemetrexed-based chemotherapy assessed homocysteine levels after 3 weeks of vitamin supplementation, hypothesising high levels would correlate with ongoing deficiency, thus increased toxicity.Material and methodsPrimary endpoint was the composite of proportion of patients with treatment delay/ dose reduction/ drug change or hospitalisation during the first six weeks of chemotherapy, comparing those with normal plasma homocysteine (successfully supplemented, SS) and those with high homocysteine (unsuccessfully supplemented, USS). Secondary endpoints included toxicity and analyses for depression. Post-hoc analysis examined correlation between interval of vitamin and folate supplementation and pemetrexed on primary endpoint and grade 3-4 toxicities.ResultsEighty-four patients (84%) were successfully supplemented (SS group). The proportion of patients undergoing a treatment delay/ dose reduction/ drug change or hospitalisation in SS group was 44.0% (95% confidence interval [CI] 33.2%-55.3%) and in USS group was 18.8% (95% CI 4.0%-45.6%) (p = 0.09). Twelve percent of patients gave a past history of depression however 66% of patients had an on study Hospital Anxiety and Depression (HAD) score of >7. Supplementation status was not associated with depression. The median overall survival (OS) was 11.8 months (95% CI 8.6-16.5) in the SS group and 8.8 months (95% CI 6.6-16.2) in the US group (p = 0.5). The number of days (ConclusionOn-treatment homocysteine levels were not a biomarker of toxicity or depression. Standard vitamin supplementation is adequate in the majority of patients receiving pemetrexed. High HAD score were noted in this population giving an opportunity for mental health intervention. The lead-in time for vitamin supplementation can be short.

Published
2019
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2. The Simons Observatory: science goals andforecasts

Author

Peter Ade, James Aguirre, Zeeshan Ahmed, Simone Aiola, Aamir Ali, David Alonso, Marcelo A. Alvarez, Kam Arnold, Peter Ashton, Jason Austermann, Humna Awan, Carlo Baccigalupi, Taylor Baildon, Darcy Barron, Nick Battaglia, Richard Battye, Eric Baxter, Andrew Bazarko, James A. Beall, Rachel Bean, Dominic Beck, Shawn Beckman, Benjamin Beringue, Federico Bianchini, Steven Boada, David Boettger, J. Richard Bond, Julian Borrill, Michael L. Brown, Sarah Marie Bruno, Sean Bryan, Erminia Calabrese, Victoria Calafut, Paolo Calisse, Julien Carron, Anthony Challinor, Grace Chesmore, Yuji Chinone, Jens Chluba, Hsiao-Mei Sherry Cho, Steve Choi, Gabriele Coppi, Nicholas F. Cothard, Kevin Coughlin, Devin Crichton, Kevin D. Crowley, Kevin T. Crowley, Ari Cukierman, John M. D'Ewart, Rolando Dünner, Tijmen de Haan, Mark Devlin, Simon Dicker, Joy Didier, Matt Dobbs, Bradley Dober, Cody J. Duell, Shannon Duff, Adri Duivenvoorden, Jo Dunkley, John Dusatko, Josquin Errard, Giulio Fabbian, Stephen Feeney, Simone Ferraro, Pedro Fluxà, Katherine Freese, Josef C. Frisch, Andrei Frolov, George Fuller, Brittany Fuzia, Nicholas Galitzki, Patricio A. Gallardo, Jose Tomas Galvez Ghersi, Jiansong Gao, Eric Gawiser, Martina Gerbino, Vera Gluscevic, Neil Goeckner-Wald, Joseph Golec, Sam Gordon, Megan Gralla, Daniel Green, Arpi Grigorian, John Groh, Chris Groppi, Yilun Guan, Jon E. Gudmundsson, Dongwon Han, Peter Hargrave, Masaya Hasegawa, Matthew Hasselfield, Makoto Hattori, Victor Haynes, Masashi Hazumi, Yizhou He, Erin Healy, Shawn W. Henderson, Carlos Hervias-Caimapo, Charles A. Hill, J. Colin Hill, Gene Hilton, Matt Hilton, Adam D. Hincks, Gary Hinshaw, Renée Hložek, Shirley Ho, Shuay-Pwu Patty Ho, Logan Howe, Zhiqi Huang, Johannes Hubmayr, Kevin Huffenberger, John P. Hughes, Anna Ijjas, Margaret Ikape, Kent Irwin, Andrew H. Jaffe, Bhuvnesh Jain, Oliver Jeong, Daisuke Kaneko, Ethan D. Karpel, Nobuhiko Katayama, Brian Keating, Sarah S. Kernasovskiy, Reijo Keskitalo, Theodore Kisner, Kenji Kiuchi, Jeff Klein, Kenda Knowles, Brian Koopman, Arthur Kosowsky, Nicoletta Krachmalnicoff, Stephen E. Kuenstner, Chao-Lin Kuo, Akito Kusaka, Jacob Lashner, Adrian Lee, Eunseong Lee, David Leon, Jason S.-Y. Leung, Antony Lewis, Yaqiong Li, Zack Li, Michele Limon, Eric Linder, Carlos Lopez-Caraballo, Thibaut Louis, Lindsay Lowry, Marius Lungu, Mathew Madhavacheril, Daisy Mak, Felipe Maldonado, Hamdi Mani, Ben Mates, Frederick Matsuda, Loïc Maurin, Phil Mauskopf, Andrew May, Nialh McCallum, Chris McKenney, Jeff McMahon, P. Daniel Meerburg, Joel Meyers, Amber Miller, Mark Mirmelstein, Kavilan Moodley, Moritz Munchmeyer, Charles Munson, Sigurd Naess, Federico Nati, Martin Navaroli, Laura Newburgh, Ho Nam Nguyen, Michael Niemack, Haruki Nishino, John Orlowski-Scherer, Lyman Page, Bruce Partridge, Julien Peloton, Francesca Perrotta, Lucio Piccirillo, Giampaolo Pisano, Davide Poletti, Roberto Puddu, Giuseppe Puglisi, Chris Raum, Christian L. Reichardt, Mathieu Remazeilles, Yoel Rephaeli, Dominik Riechers, Felipe Rojas, Anirban Roy, Sharon Sadeh, Yuki Sakurai, Maria Salatino, Mayuri Sathyanarayana Rao, Emmanuel Schaan, Marcel Schmittfull, Neelima Sehgal, Joseph Seibert, Uros Seljak, Blake Sherwin, Meir Shimon, Carlos Sierra, Jonathan Sievers, Precious Sikhosana, Maximiliano Silva-Feaver, Sara M. Simon, Adrian Sinclair, Praween Siritanasak, Kendrick Smith, Stephen R. Smith, David Spergel, Suzanne T. Staggs, George Stein, Jason R. Stevens, Radek Stompor, Aritoki Suzuki, Osamu Tajima, Satoru Takakura, Grant Teply, Daniel B. Thomas, Ben Thorne, Robert Thornton, Hy Trac, Calvin Tsai, Carole Tucker, Joel Ullom, Sunny Vagnozzi, Alexander van Engelen, Jeff Van Lanen, Daniel D. Van Winkle, Eve M. Vavagiakis, Clara Vergès, Michael Vissers, Kasey Wagoner, Samantha Walker, Jon Ward, Ben Westbrook, Nathan Whitehorn, Jason Williams, Joel Williams, Edward J. Wollack, Zhilei Xu, Byeonghee Yu, Cyndia Yu, Fernando Zago, Hezi Zhang, and Ningfeng Zhu

Subjects
Astrophysics, Astronomy
Abstract

The Simons Observatory (SO) is a new cosmic microwave background experiment being built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the scientific goals of the experiment, motivate the design, and forecast its performance. SO will measure the temperature and polarization anisotropy of the cosmic microwave background in six frequency bands centered at: 27, 39, 93, 145, 225 and 280 GHz. The initial configuration of SO will have three small-aperture 0.5-m telescopes and one large-aperture 6-m telescope, with a total of 60,000 cryogenic bolometers. Our key science goals are to characterize the primordial perturbations, measure the number of relativistic species and the mass of neutrinos, test for deviations from a cosmological constant, improve our understanding of galaxy evolution, and constrain the duration of reionization. The small aperture telescopes will target the largest angular scales observable from Chile, mapping ≈ 10% of the sky to a white noise level of 2 μK-arcmin in combined 93 and 145 GHz bands, to measure the primordial tensor-to-scalar ratio, r, at a target level of σ(r)=0.003. The large aperture telescope will map ≈ 40% of the sky at arcminute angular resolution to an expected white noise level of 6 μK-arcmin in combined 93 and 145 GHz bands, overlapping with the majority of the Large Synoptic Survey Telescope sky region and partially with the Dark Energy Spectroscopic Instrument. With up to an order of magnitude lower polarization noise than maps from the Planck satellite, the high-resolution sky maps will constrain cosmological parameters derived from the damping tail, gravitational lensing of the microwave background, the primordial bispectrum, and the thermal and kinematic Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle polarization signal to measure the tensor-to-scalar ratio. The survey will also provide a legacy catalog of 16,000 galaxy clusters and more than 20,000 extragalactic sources.

Published
2019
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3. A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma

Author

Andrew Hodgkiss, Daisy Mak, Rajesh Kumar, Mary O'Brien, Jaishree Bhosle, R. Gunapala, D. Walder, Sanjay Popat, Anna Minchom, and Nadia Yousaf

Subjects
Male, Mesothelioma, B Vitamins, Lung Neoplasms, Homocysteine, Cancer Treatment, Toxicology, Pathology and Laboratory Medicine, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Medicine and Health Sciences, Clinical endpoint, Medicine, Prospective Studies, Prospective cohort study, Aged, 80 and over, education.field_of_study, Multidisciplinary, Depression, Organic Compounds, Pharmaceutics, Vitamins, Middle Aged, Vitamin B 12, Chemistry, Treatment Outcome, Pemetrexed, Oncology, 030220 oncology & carcinogenesis, Physical Sciences, Toxicity, Female, Research Article, medicine.drug, Adult, Vitamin, medicine.medical_specialty, General Science & Technology, Science, Population, Cobalamins, 03 medical and health sciences, Folic Acid, Drug Therapy, Internal medicine, Mental Health and Psychiatry, Humans, Chemotherapy, Vitamin B12, education, Aged, Mood Disorders, business.industry, Mesothelioma, Malignant, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, 030228 respiratory system, chemistry, Dietary Supplements, business, Biomarkers
Abstract

ObjectivesVitamin supplementation reduces pemetrexed toxicity. Raised plasma homocysteine reflects deficiency in vitamin B12 and folate, and is suppressed by supplementation. This observational study of 112 patients receiving pemetrexed-based chemotherapy assessed homocysteine levels after 3 weeks of vitamin supplementation, hypothesising high levels would correlate with ongoing deficiency, thus increased toxicity.Material and methodsPrimary endpoint was the composite of proportion of patients with treatment delay/ dose reduction/ drug change or hospitalisation during the first six weeks of chemotherapy, comparing those with normal plasma homocysteine (successfully supplemented, SS) and those with high homocysteine (unsuccessfully supplemented, USS). Secondary endpoints included toxicity and analyses for depression. Post-hoc analysis examined correlation between interval of vitamin and folate supplementation and pemetrexed on primary endpoint and grade 3-4 toxicities.ResultsEighty-four patients (84%) were successfully supplemented (SS group). The proportion of patients undergoing a treatment delay/ dose reduction/ drug change or hospitalisation in SS group was 44.0% (95% confidence interval [CI] 33.2%-55.3%) and in USS group was 18.8% (95% CI 4.0%-45.6%) (p = 0.09). Twelve percent of patients gave a past history of depression however 66% of patients had an on study Hospital Anxiety and Depression (HAD) score of >7. Supplementation status was not associated with depression. The median overall survival (OS) was 11.8 months (95% CI 8.6-16.5) in the SS group and 8.8 months (95% CI 6.6-16.2) in the US group (p = 0.5). The number of days (ConclusionOn-treatment homocysteine levels were not a biomarker of toxicity or depression. Standard vitamin supplementation is adequate in the majority of patients receiving pemetrexed. High HAD score were noted in this population giving an opportunity for mental health intervention. The lead-in time for vitamin supplementation can be short.

Published
2019

4. The Simons Observatory: Astro2020 APC Whitepaper

Author

Abitbol, Maximilian H., Shunsuke, Adachi, Peter, Ade, James, Aguirre, Zeeshan, Ahmed, Simone, Aiola, Aamir, Ali, David, Alonso, Alvarez, Marcelo A., Kam, Arnold, Peter, Ashton, Zachary, Atkins, Jason, Austermann, Humna, Awan, Carlo, Baccigalupi, Taylor, Baildon, Anton Baleato Lizancos, Darcy, Barron, Nick, Battaglia, Richard, Battye, Eric, Baxter, Andrew, Bazarko, Beall, James A., Rachel, Bean, Dominic, Beck, Shawn, Beckman, Benjamin, Beringue, Tanay, Bhandarkar, Sanah, Bhimani, Federico, Bianchini, Steven, Boada, David, Boettger, Boris, Bolliet, Richard Bond, J., Julian, Borrill, Brown, Michael L., Sarah Marie Bruno, Sean, Bryan, Erminia, Calabrese, Victoria, Calafut, Paolo, Calisse, Julien, Carron, Carl, Fred. M., Juan, Cayuso, Anthony, Challinor, Grace, Chesmore, Yuji, Chinone, Jens, Chluba, Hsiao-Mei Sherry Cho, Steve, Choi, Susan, Clark, Philip, Clarke, Carlo, Contaldi, Gabriele, Coppi, Cothard, Nicholas F., Kevin, Coughlin, Will, Coulton, Devin, Crichton, Crowley, Kevin D., Crowley, Kevin T., Ari, Cukierman, D'Ewart, John M., Rolando, Dünner, Tijmen de Haan, Mark, Devlin, Simon, Dicker, Bradley, Dober, Duell, Cody J., Shannon, Duff, Adri, Duivenvoorden, Dunkley, Jo, Hamza El Bouhargani, Josquin, Errard, Giulio, Fabbian, Stephen, Feeney, James, Fergusson, Simone, Ferraro, Pedro, Fluxà, Katherine, Freese, Frisch, Josef C., Andrei, Frolov, George, Fuller, Nicholas, Galitzki, Gallardo, Patricio A., Jose Tomas Galvez Ghersi, Jiansong, Gao, Eric, Gawiser, Martina, Gerbino, Vera, Gluscevic, Neil, Goeckner-Wald, Joseph, Golec, Sam, Gordon, Megan, Gralla, Daniel, Green, Arpi, Grigorian, John, Groh, Chris, Groppi, Yilun, Guan, Gudmundsson, Jon E., Mark, Halpern, Dongwon, Han, Peter, Hargrave, Kathleen, Harrington, Masaya, Hasegawa, Matthew, Hasselfield, Makoto, Hattori, Victor, Haynes, Masashi, Hazumi, Erin, Healy, Henderson, Shawn W., Brandon, Hensley, Carlos, Hervias-Caimapo, Hill, Charles A., Colin Hill, J., Gene, Hilton, Matt, Hilton, Hincks, Adam D., Gary, Hinshaw, Renée, Hložek, Shirley, Ho, Shuay-Pwu Patty Ho, Hoang, Thuong D., Jonathan, Hoh, Hotinli, Selim C., Zhiqi, Huang, Johannes, Hubmayr, Kevin, Huffenberger, Hughes, John P., Anna, Ijjas, Margaret, Ikape, Kent, Irwin, Jaffe, Andrew H., Bhuvnesh, Jain, Oliver, Jeong, Matthew, Johnson, Daisuke, Kaneko, Karpel, Ethan D., Nobuhiko, Katayama, Brian, Keating, Reijo, Keskitalo, Theodore, Kisner, Kenji, Kiuchi, Jeff, Klein, Kenda, Knowles, Anna, Kofman, Brian, Koopman, Arthur, Kosowsky, Nicoletta, Krachmalnicoff, Akito, Kusaka, Phil, Laplante, Jacob, Lashner, Adrian, Lee, Eunseong, Lee, Antony, Lewis, Yaqiong, Li, Zack, Li, Michele, Limon, Eric, Linder, Jia, Liu, Carlos, Lopez-Caraballo, Thibaut, Louis, Marius, Lungu, Mathew, Madhavacheril, Daisy, Mak, Felipe, Maldonado, Hamdi, Mani, Ben, Mates, Frederick, Matsuda, Loïc, Maurin, Phil, Mauskopf, Andrew, May, Nialh, Mccallum, Heather, Mccarrick, Chris, Mckenney, Jeff, Mcmahon, Daniel Meerburg, P., James, Mertens, Joel, Meyers, Amber, Miller, Mark, Mirmelstein, Kavilan, Moodley, Jenna, Moore, Moritz, Munchmeyer, Charles, Munson, Masaaki, Murata, Sigurd, Naess, Toshiya, Namikawa, Federico, Nati, Martin, Navaroli, Laura, Newburgh, Ho Nam Nguyen, Andrina, Nicola, Mike, Niemack, Haruki, Nishino, Yume, Nishinomiya, John, Orlowski-Scherer, Luca, Pagano, Bruce, Partridge, Francesca, Perrotta, Phumlani, Phakathi, Lucio, Piccirillo, Elena, Pierpaoli, Giampaolo, Pisano, Davide, Poletti, Roberto, Puddu, Giuseppe, Puglisi, Chris, Raum, Reichardt, Christian L., Mathieu, Remazeilles, Yoel, Rephaeli, Dominik, Riechers, Felipe, Rojas, Aditya, Rotti, Anirban, Roy, Sharon, Sadeh, Yuki, Sakurai, Maria, Salatino, Mayuri Sathyanarayana Rao, Lauren, Saunders, Emmanuel, Schaan, Marcel, Schmittfull, Neelima, Sehgal, Joseph, Seibert, Uros, Seljak, Paul, Shellard, Blake, Sherwin, Meir, Shimon, Carlos, Sierra, Jonathan, Sievers, Cristobal, Sifon, Precious, Sikhosana, Maximiliano, Silva-Feaver, Simon, Sara M., Adrian, Sinclair, Kendrick, Smith, Wuhyun, Sohn, Rita, Sonka, David, Spergel, Jacob, Spisak, Staggs, Suzanne T., George, Stein, Stevens, Jason R., Radek, Stompor, Aritoki, Suzuki, Osamu, Tajima, Satoru, Takakura, Grant, Teply, Thomas, Daniel B., Ben, Thorne, Robert, Thornton, Trac, Hy, Jesse, Treu, Calvin, Tsai, Carole, Tucker, Joel, Ullom, Vagnozzi, Sunny, Alexander van Engelen, Jeff Van Lanen, Van Winkle, Daniel D., Vavagiakis, Eve M., Clara, Vergès, Michael, Vissers, Kasey, Wagoner, Samantha, Walker, Yuhan, Wang, Jon, Ward, Ben, Westbrook, Nathan, Whitehorn, Jason, Williams, Joel, Williams, Edward, Wollack, Zhilei, Xu, Siavash, Yasini, Edward, Young, Byeonghee, Yu, Cyndia, Yu, Fernando, Zago, Mario, Zannoni, Hezi, Zhang, Kaiwen, Zheng, Ningfeng, Zhu, and Andrea, Zonca

Published
2019

5. Electrical characterization and tuning of the integrated POLARBEAR-2a focal plane and readout (Conference Presentation)

Author

J. Borrill, Paul L. Richards, Stephen M. Feeney, A. T. P. Pham, J. Peloton, Darcy Barron, Mario Aguilar, Josquin Errard, L. N. Lowry, D. Beck, A. Cukierman, Akito Kusaka, M. Le Jeune, Neil Goeckner-Wald, Max Silva Feaver, W. L. Holzapfel, Nicoletta Krachmalnicoff, Gabriele Coppi, H. Roberts, Peter Ashton, A. Tikhomirov, M. A. Dobbs, Osamu Tajima, D. Leon, Masashi Hazumi, P. A. R. Ade, Grant Teply, Nathan J. Miller, Colin Ross, Nicholas Galitzki, P. Siritanasak, Blake D. Sherwin, Tucker Elleflot, Y. Akiba, K. M. Rotermund, S. Beckman, A. J. Gilbert, Christian L. Reichardt, R. Dunner, Gary A. Fuller, Oliver Jeong, Eric V. Linder, A. Madurowicz, Giulio Fabbian, John Groh, Jessica Avva, Yuki Inoue, S. Takatori, G. Jaehnig, Carlo Baccigalupi, Giuseppe Puglisi, Charles A. Hill, S. Takakura, Andrew May, Scott Chapman, D. Plambeck, Kevin T. Crowley, D. Tanabe, Kam Arnold, Brian Keating, Aamir Ali, Benjamin Westbrook, M. Navroli, Adrian T. Lee, Jennifer Ito, Masaya Hasegawa, Aritoki Suzuki, Federico Bianchini, Theodore Kisner, Julien Carron, Tomotake Matsumura, Reijo Keskitalo, Daisuke Kaneko, Y. Segawa, T. Natoli, Frederick Matsuda, Yuji Chinone, N. W. Halverson, R. Stompor, T. de Haan, T. Hamada, A. Zahn, Amy N. Bender, D. Boettger, Takayuki Tomaru, R. Tat, A. Lowitz, Chang Feng, C. Tsai, Lucio Piccirillo, Leo Steinmetz, Nobuhiko Katayama, Daisy Mak, Davide Poletti, C. Verges, L. Howe, Haruki Nishino, A. Anderson, Yuto Minami, Gabriel M. Rebeiz, Nathan Whitehorn, Christopher Raum, Joshua Montgomery, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
temperature: transition, Cosmic microwave background, cosmic background radiation: polarization, frequency-division multiplexing, Astrophysics::Cosmology and Extragalactic Astrophysics, SQUID, 01 natural sciences, 010305 fluids & plasmas, law.invention, cosmic background radiation: B-mode, Optics, bolometer, gravitation: lens, law, 0103 physical sciences, millimeter-wave, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], inflation, 010306 general physics, Physics, Gravitational wave, business.industry, superconductivity, Detector, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, gravitational radiation: primordial, Spectral density, cosmic microwave background polarization, stability, Polarization (waves), transition-edge sensor, Extremely high frequency, resonance: frequency, power spectrum: angular dependence, readout, dfmux, Transition edge sensor, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

International audience; POLARBEAR is a cosmic microwave background (CMB) polarization experiment located in the Atacama desert in Chile. The science goals of the POLARBEAR project are to do a deep search for CMB B-mode polarization created by inflationary gravitational waves, as well as characterize the CMB B-mode signal from gravitational lensing. POLARBEAR-1 started observations in 2012, and the POLARBEAR team has published a series of results from its first two seasons of observations, including the first measurement of a non-zero B-mode polarization angular power spectrum, measured at sub-degree scales where the dominant signal is gravitational lensing of the CMB. The Simons Array expands POLARBEAR to include an additional two telescopes with next-generation POLARBEAR-2 multi-chroic receivers, observing at 95, 150, 220, and 270 GHz.The POLARBEAR-2A focal plane has 7,588 transition-edge sensor bolometers, read out with frequency-division multiplexing, with 40 frequency channels within the readout bandwidth of 1.5 to 4.5 MHz. The frequency channels are defined by a low-loss lithographed aluminum spiral inductor and interdigitated capacitor in series with each bolometer, creating a resonant frequency for each channel's unique voltage bias and current readout. Characterization of the readout includes measuring resonant peak locations and heights and fitting to a circuit model both above and below the bolometer superconducting transition temperature. This information is used determine the optimal detector bias frequencies and characterize stray impedances which may affect bolometer operation and stability. The detector electrical characterization includes measurements of the transition properties by sweeping in temperature and in voltage bias, measurements of the bolometer saturation power, as well as measuring and removing any biases introduced by the readout circuit. We present results from the characterization, tuning, and operation of the fully integrated focal plane and readout for the first POLARBEAR-2 receiver, POLARBEAR-2A, during its pre-deployment integration run.

Published
2018

6. The POLARBEAR-2 and Simons Array Focal Plane Fabrication Status

Author

Adrian T. Lee, Neil Goeckner-Wald, D. Beck, D. Leon, A. Cukierman, M. Navaroli, Brian Keating, Y. Segawa, Tucker Elleflot, Masaya Hasegawa, Maximiliano Silva-Feaver, Peter A. R. Ade, Y. Akiba, Matt Dobbs, Julian Borrill, Paul L. Richards, Stephen M. Feeney, Rolando Dünner, K. M. Rotermund, C. Tsai, Oliver Jeong, Osamu Tajima, A. T. P. Pham, Eric V. Linder, Gabriel M. Rebeiz, Josquin Errard, S. Takakura, D. Plambeck, Lucio Piccirillo, Nathan Whitehorn, Yuji Chinone, S. Beckman, Giulio Fabbian, L. Howe, M. Le Jeune, Federico Bianchini, Christopher Raum, Daisy Mak, Grant Teply, W. L. Holzapfel, Andrew May, Joshua Montgomery, Carlo Baccigalupi, H. Roberts, S. Takatori, Christian L. Reichardt, Reijo Keskitalo, A. J. Gilbert, Gary A. Fuller, R. Tat, Akito Kusaka, Nobuhiko Katayama, D. Boettger, A. Tikhomirov, John Groh, Benjamin Westbrook, Giuseppe Puglisi, Charles A. Hill, Scott Chapman, Nicoletta Krachmalnicoff, Colin Ross, Amy N. Bender, A. Madurowicz, Darcy Barron, J. Peloton, N. W. Halverson, L. N. Lowry, Aritoki Suzuki, Chang Feng, Andrew H. Jaffe, Takayuki Tomaru, Davide Poletti, A. Zahn, Radek Stompor, Mario Ferrada Aguilar, Theodore Kisner, T. de Haan, T. Hamada, Gabriele Coppi, Yuto Minami, Yuki Inoue, Nathan J. Miller, D. Tanabe, H. Nishino, G. Jaehnig, Masashi Hazumi, Nicholas Galitzki, Blake D. Sherwin, Kevin D. Crowley, Kam Arnold, Frederick Matsuda, D. Kaneko, Praween Siritanasak, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Westbrook, B, Ade, P, Aguilar, M, Akiba, Y, Arnold, K, Baccigalupi, C, Barron, D, Beck, D, Beckman, S, Bender, A, Bianchini, F, Boettger, D, Borrill, J, Chapman, S, Chinone, Y, Coppi, G, Crowley, K, Cukierman, A, de Haan, T, Dunner, R, Dobbs, M, Elleflot, T, Errard, J, Fabbian, G, Feeney, S, Feng, C, Fuller, G, Galitzki, N, Gilbert, A, Goeckner-Wald, N, Groh, J, Halverson, N, Hamada, T, Hasegawa, M, Hazumi, M, Hill, C, Holzapfel, W, Howe, L, Inoue, Y, Jaehnig, G, Jaffe, A, Jeong, O, Kaneko, D, Katayama, N, Keating, B, Keskitalo, R, Kisner, T, Krachmalnicoff, N, Kusaka, A, Le Jeune, M, Lee, A, Leon, D, Linder, E, Lowry, L, Madurowicz, A, Mak, D, Matsuda, F, May, A, Miller, N, Minami, Y, Montgomery, J, Navaroli, M, Nishino, H, Peloton, J, Pham, A, Piccirillo, L, Plambeck, D, Poletti, D, Puglisi, G, Raum, C, Rebeiz, G, Reichardt, C, Richards, P, Roberts, H, Ross, C, Rotermund, K, Segawa, Y, Sherwin, B, Silva-Feaver, M, Siritanasak, P, Stompor, R, Suzuki, A, Tajima, O, Takakura, S, Takatori, S, Tanabe, D, Tat, R, Teply, G, Tikhomirov, A, Tomaru, T, Tsai, C, Whitehorn, N, Zahn, A, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)

Subjects
Cosmic microwave background, cosmic background radiation: polarization, CMB, Dichroic glass, 01 natural sciences, law.invention, law, Atomic and Molecular Physics, Polarization, General Materials Science, silicon: nitrogen, Instrumentation, Mathematical Physics, 010302 applied physics, Physics, Settore FIS/05, superconductivity, Detector, Detectors, Polarization (waves), Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Cardinal point, Materials Science (all), silicon: oxygen, Astrophysics - Instrumentation and Methods for Astrophysics, Transition edge sensor, performance, Astrophysics - Cosmology and Nongalactic Astrophysics, Fabrication, Sinuous antenna, Inflation, General Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Classical Physics, FOS: Physical sciences, Telescope, Optics, Settore FIS/05 - Astronomia e Astrofisica, bolometer, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), detector: design, activity report, business.industry, Bolometer, and Optics, business
Abstract

著者人数: 93名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 羽澄, 昌史), Accepted: 2018-08-27, 資料番号: SA1180208000

Published
2017

7. Treatment response in the neck: p16+ versus p16− oropharyngeal cancer

Author

Daisy Mak, June Corry, Danny Rischin, Lester J. Peters, Rodney J. Hicks, Mathias Bressel, Richard J. Young, and Ben Solomon

Subjects
medicine.diagnostic_test, business.industry, Cancer, Physical examination, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, Positron emission tomography, Carcinoma, medicine, Radiology, Nuclear Medicine and imaging, Tirapazamine, Stage (cooking), Nuclear medicine, business, NODAL, Chemoradiotherapy
Abstract

Introduction To compare nodal response rates following chemoradiotherapy in patients with p16+ and p16− oropharyngeal squamous cell carcinoma (OPSCC). Methods Patients with node-positive OPSCC treated at Peter MacCallum Cancer Centre on the published phase I–III tirapazamine trials were identified. All patients had conventional assessment (clinical examination (CA), CT and/or MRI) and positron emission tomography (PET) at both baseline and 2–4 months post-treatment. Results There were 30 p16+ and 18 p16− patients, the former group having significantly higher stage nodal disease (P = 0.016). The mean overall reduction in nodal size at post-treatment assessment was similar in p16+ and p16− patients (78% vs. 75%), and no statistically significant difference in nodal complete response (CR) rates was detected by either CA (50% vs. 39%, P = 0.35) or PET/PET-CT (93% vs. 83%, P = 0.19). PET was significantly more accurate in determining the true nodal CR rate in both groups, with a negative predictive value of 96%. Conclusion Nodal response rates following chemoradiotherapy appear to be similar in p16+ and p16− patients when assessed by either CA or PET/PET-CT. However, higher nodal CR was seen in PET/PET-CT compared with CA in both groups. Metabolic imaging is more accurate than CA in assessing nodal response post-treatment.

Published
2013

8. Demonstration of Cosmic Microwave Background Delensing Using the Cosmic Infrared Background

Author

Anthony Challinor, Patricia Larsen, Daisy Mak, Blake D. Sherwin, Challinor, Anthony [0000-0003-3479-7823], and Apollo - University of Cambridge Repository

Subjects
Physics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), 010308 nuclear & particles physics, Cosmic microwave background, Strong gravitational lensing, General Physics and Astronomy, Astronomy, Spectral density, FOS: Physical sciences, Planck temperature, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, symbols.namesake, Amplitude, Gravitational lens, Cosmic infrared background, 0103 physical sciences, symbols, astro-ph.CO, Planck, 010303 astronomy & astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Delensing is an increasingly important technique to reverse the gravitational lensing of the cosmic microwave background (CMB) and thus reveal primordial signals the lensing may obscure. We present a first demonstration of delensing on Planck temperature maps using the cosmic infrared background (CIB). Reversing the lensing deflections in Planck CMB temperature maps using a linear combination of the 545 and 857GHz maps as a lensing tracer, we find that the lensing effects in the temperature power spectrum are reduced in a manner consistent with theoretical expectations. In particular, the characteristic sharpening of the acoustic peaks of the temperature power spectrum resulting from successful delensing is detected at a significance of 16$\rm{\sigma}$, with an amplitude of $A_{\rm{delens}} = 1.12 \pm 0.07$ relative to the expected value of unity. This first demonstration on data of CIB delensing, and of delensing techniques in general, is significant because lensing removal will soon be essential for achieving high-precision constraints on inflationary B-mode polarization., Comment: 6 pages, 5 figures, accepted for publication in PRL

Published
2016

9. The use of PET in assessing tumor response after neoadjuvant chemoradiation for rectal cancer

Author

Daisy Mak, Joanne McNamara, Michael Chao, M. Feigen, Michael Lim Joon, Aurora M T Poon, Patricia Jenkins, Andrew See, Daryl Lim Joon, A Mercuri, Morikatsu Wada, and Vincent Khoo

Subjects
Adult, Male, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Rectum, Disease, Tumor response, Endorectal ultrasound, Fluorodeoxyglucose F18, medicine, Humans, Radiology, Nuclear Medicine and imaging, Large intestine, Pathological, Aged, Neoplasm Staging, Retrospective Studies, Rectal Neoplasms, business.industry, Hematology, Middle Aged, medicine.disease, Neoadjuvant Therapy, Radiation therapy, Treatment Outcome, medicine.anatomical_structure, Oncology, Positron-Emission Tomography, Female, Radiology, business, Follow-Up Studies
Abstract

Purpose To assess the correlation of 18F-FDG-PET (PET) response to pathological response after neoadjuvant chemoradiation (CRT) for locally advanced rectal cancer. Methods and materials Twenty patients with locally advanced rectal cancer were identified between 2001 and 2005. The median age was 57 years (range 37–72) with 14 males and 6 females. All patients were staged with endorectal ultrasound and/or MRI, CT, and PET. The clinical staging was T3N0M0 (16), T3N1M0 (2), and T3N0M1 (2). Restaging PET was performed after CRT, and prior to definitive surgery. The response on PET and pathology was assessed and correlated. Patient outcome according to PET response was also assessed. Results Following CRT, a complete PET response occurred in 7 patients, incomplete response in 10, and no response in 3 patients. At surgery, complete pathological response was recorded in 7 patients, incomplete response in 10 and no response in 3. There was a good correlation of PET and pathological responses in complete responders (5/7 cases) and non-responders (3/3 cases). After a median follow-up of 62 months (range 7–73), twelve patients were alive with no evidence of disease. All patients achieving complete metabolic response were alive with no evidence of disease, while as those who had no metabolic response, all died as a result of metastatic disease. Conclusions PET is a promising complementary assessment tool for assessing tumor response after CRT if there is a complete or no response. PET response may also predict for outcome.

Published
2010

10. Seminal vesicle interfraction displacement and margins in image guided radiotherapy for prostate cancer

Author

Kellie Knight, Jessica Thomas, Gillian M. Duchesne, Tomas Kron, Farshad Foroudi, Suki Gill, Annette Haworth, Roxby Paul, Daisy Mak, Jim Cramb, and A. Stillie

Subjects
Male, lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, Movement, lcsh:R895-920, medicine.medical_treatment, Urinary Bladder, Urology, Rectum, lcsh:RC254-282, Cohort Studies, Prostate cancer, Seminal vesicle, Prostate, medicine, Humans, Radiology, Nuclear Medicine and imaging, Displacement (orthopedic surgery), Aged, Urinary bladder, Radiotherapy, business.industry, Radiotherapy Planning, Computer-Assisted, Research, Prostatic Neoplasms, Seminal Vesicles, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Radiation therapy, Margins, medicine.anatomical_structure, Oncology, Radiology Nuclear Medicine and imaging, Interfraction displacement, Tomography, Radiotherapy, Conformal, Tomography, X-Ray Computed, business, Nuclear medicine, Radiotherapy, Image-Guided
Abstract

Background To analyze interfraction motion of seminal vesicles (SV), and its motion relative to rectal and bladder filling. Methods and Materials SV and prostate were contoured on 771 daily computed tomography “on rails” scans from 24 prostate cancer patients undergoing radiotherapy. Random and systematic errors for SV centroid displacement were measured relative to the prostate centroid. Margins required for complete geometric coverage of SV were determined using isotropic expansion of reference contours. SV motion relative to rectum and bladder was determined. Results Systematic error for the SV was 1.9 mm left-right (LR), 2.9 mm anterior-posterior (AP) and 3.6 mm superior-inferior (SI). Random error was 1.4 mm (LR), 2.7 mm (AP) and 2.1 mm (SI). 10 mm margins covered the entire left SV and right SV on at least 90% of fractions in 50% and 33% of patients and 15 mm margins covered 88% and 79% respectively. SV AP movement correlated with movement of the most posterior point of the bladder (mean R2 = 0.46, SD = 0.24) and rectal area (mean R2 = 0.38, SD = 0.21). Conclusions Considerable interfraction displacement of SV was observed in this cohort of patients. Bladder and rectal parameters correlated with SV movement.

Published
2012

11. Treatment response in the neck: p16+ versus p16- oropharyngeal cancer

Author

Daisy, Mak, Rodney J, Hicks, Danny, Rischin, Ben, Solomon, Lester, Peters, Mathias, Bressel, Richard J, Young, and June, Corry

Subjects
Adult, Male, Radiation-Sensitizing Agents, Triazines, Antineoplastic Agents, Chemoradiotherapy, Middle Aged, Neoplasm Proteins, Oropharyngeal Neoplasms, Treatment Outcome, Biomarkers, Tumor, Carcinoma, Squamous Cell, Humans, Female, Tirapazamine, Cyclin-Dependent Kinase Inhibitor p16, Aged
Abstract

To compare nodal response rates following chemoradiotherapy in patients with p16+ and p16- oropharyngeal squamous cell carcinoma (OPSCC).Patients with node-positive OPSCC treated at Peter MacCallum Cancer Centre on the published phase I-III tirapazamine trials were identified. All patients had conventional assessment (clinical examination (CA), CT and/or MRI) and positron emission tomography (PET) at both baseline and 2-4 months post-treatment.There were 30 p16+ and 18 p16- patients, the former group having significantly higher stage nodal disease (P = 0.016). The mean overall reduction in nodal size at post-treatment assessment was similar in p16+ and p16- patients (78% vs. 75%), and no statistically significant difference in nodal complete response (CR) rates was detected by either CA (50% vs. 39%, P = 0.35) or PET/PET-CT (93% vs. 83%, P = 0.19). PET was significantly more accurate in determining the true nodal CR rate in both groups, with a negative predictive value of 96%.Nodal response rates following chemoradiotherapy appear to be similar in p16+ and p16- patients when assessed by either CA or PET/PET-CT. However, higher nodal CR was seen in PET/PET-CT compared with CA in both groups. Metabolic imaging is more accurate than CA in assessing nodal response post-treatment.

Published
2012

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