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Magnesium (Mg), an essential nutrient with a wide area of physiological roles, stands as a cofactor in over 600 enzymatic reactions involved in the synthesis of proteins and nucleic acids, DNA repair, neuromuscular functions, neuronal transmission, cardiac rhythm regulation, and the modulation of metabolic pathways, as well as acting as a natural blocker for the calcium channels. Our objective was to highlight the most recent clinical data with respect to daily Mg intake (DMI) and metabolic traits, particularly type 2 diabetes mellitus (DM). This was a PubMed-based review of the English-language medical papers across different key terms of search; the time frame was from January 2019 until April 2024. We included (clinically relevant) original studies and excluded cases reports, series, reviews, editorials, opinion, experimental studies, and non-human data as well as studies that did not specifically assessed DMI and only provided assays of serum Mg, studies on patients diagnosed with type 1 or secondary DM. A total of 30 studies were included and we organized the key findings into several sections as follows. Studies investigating DMI in relationship with the adherence to local recommendations in diabetic subjects (n = 2, one transversal and another retrospective cohort; N = 2823) found that most of them had lower DMI. Deficient DMI was correlated with the risk of developing/having DM across five studies (n = 5, one prospective and four of cross-sectional design; N = 47,166). An inverse correlation between DMI and DM prevalence was identified, but these data are presented amid a rather heterogeneous spectrum. Four novel studies (N = 7279) analysed the relationship between DMI and DM control according to various methods (HbA1c, fasting and postprandial glycaemia, and insulin); the association may be linear in diabetic subjects only at certain levels of DMI; additionally, the multifactorial influence on HBA1c should take into consideration this dietary determinant, as well, but there are no homogenous results. Three studies concerning DMI and diabetic complications (one cross-sectional, one prospective, and another case–control study) in terms of retinopathy (n = 1, N = 3794) and nephropathy (n = 2, N = 4805) suggested a lower DMI was associated with a higher risk of such complications. Additionally, two other studies (one prospective and one retrospective cohort) focused on mortality (N = 6744), which, taking only certain mortality indicators into consideration, might be decreased in the subgroups with a higher DMI. Seven studies (N = 30,610) analysed the perspective of DMI in the general population with the endpoint of different features amid glucose profile, particularly, insulin resistance. Concerning HOMA-IR, there were three confirmatory studies and one non-confirmatory, while fasting plasma glucose was highlighted as inversely correlated with a DMI (n = 1). The highest level of evidence regarding Mg supplementation effects on glucose metabolism stands on seven randomised controlled trials (N = 350). However, the sample size was reduced (from 14 to 86 individuals per study, either diabetic or pre-diabetic) and outcomes were rather discordant. These clinical aspects are essential from a multidisciplinary perspective and further trials are mandatory to address the current areas of discordant results.

The aim of the current case study is to sequentially assess the heavy metals (HMs) cadmium (Cd), iron (Fe), lead (Pb) and zinc (Zn) in five products (raw juice, bagasse, mud-cake, refined sugar and molasses) along with the effluents of the selected sugar industry (SSI) Sindh, Pakistan. Estimations of daily intake and possible toxic risk of HMs by the consumption of sugar of SSI to end-user (families of SSI workers) of age group of 2.0–5.0, 6.0–15.0, 16.0–30.0 and 31.0–50.0 years were conducted. The high contents of HMs were observed in molasses followed by mud-cake and bagasse (raw waste). The raw juice of sugarcane and refined/white sugar showed the lowest levels of these HMs. The low levels of HMs in effluents of SSI might be to their separation at different stages of sugar processing and refining into the mud-cake, bagasse and molasses. The calculated daily intake of Fe and Zn from refined/white sugar to various study groups was found to be adequate based on the recommended levels by Food and Nutrition Board (FNB). The estimated weekly intake (WI) for Cd and Pb by the consumption of SSI sugar was significantly lower (2–5 times) than the provisional acceptable WI of Cd and Pb by WHO from foodstuff. The potential toxic risk study of Cd and Pb revealed that the studied subjects were not at potential toxic risk by the consumption of SSI sugar. [ABSTRACT FROM AUTHOR]

Magnesium (Mg), an essential nutrient with a wide area of physiological roles, stands as a cofactor in over 600 enzymatic reactions involved in the synthesis of proteins and nucleic acids, DNA repair, neuromuscular functions, neuronal transmission, cardiac rhythm regulation, and the modulation of metabolic pathways, as well as acting as a natural blocker for the calcium channels. Our objective was to highlight the most recent clinical data with respect to daily Mg intake (DMI) and metabolic traits, particularly type 2 diabetes mellitus (DM). This was a PubMed-based review of the English-language medical papers across different key terms of search; the time frame was from January 2019 until April 2024. We included (clinically relevant) original studies and excluded cases reports, series, reviews, editorials, opinion, experimental studies, and non-human data as well as studies that did not specifically assessed DMI and only provided assays of serum Mg, studies on patients diagnosed with type 1 or secondary DM. A total of 30 studies were included and we organized the key findings into several sections as follows. Studies investigating DMI in relationship with the adherence to local recommendations in diabetic subjects (n = 2, one transversal and another retrospective cohort; N = 2823) found that most of them had lower DMI. Deficient DMI was correlated with the risk of developing/having DM across five studies (n = 5, one prospective and four of cross-sectional design; N = 47,166). An inverse correlation between DMI and DM prevalence was identified, but these data are presented amid a rather heterogeneous spectrum. Four novel studies (N = 7279) analysed the relationship between DMI and DM control according to various methods (HbA1c, fasting and postprandial glycaemia, and insulin); the association may be linear in diabetic subjects only at certain levels of DMI; additionally, the multifactorial influence on HBA1c should take into consideration this dietary determinant, as well, but there are no homogenous results. Three studies concerning DMI and diabetic complications (one cross-sectional, one prospective, and another case–control study) in terms of retinopathy (n = 1, N = 3794) and nephropathy (n = 2, N = 4805) suggested a lower DMI was associated with a higher risk of such complications. Additionally, two other studies (one prospective and one retrospective cohort) focused on mortality (N = 6744), which, taking only certain mortality indicators into consideration, might be decreased in the subgroups with a higher DMI. Seven studies (N = 30,610) analysed the perspective of DMI in the general population with the endpoint of different features amid glucose profile, particularly, insulin resistance. Concerning HOMA-IR, there were three confirmatory studies and one non-confirmatory, while fasting plasma glucose was highlighted as inversely correlated with a DMI (n = 1). The highest level of evidence regarding Mg supplementation effects on glucose metabolism stands on seven randomised controlled trials (N = 350). However, the sample size was reduced (from 14 to 86 individuals per study, either diabetic or pre-diabetic) and outcomes were rather discordant. These clinical aspects are essential from a multidisciplinary perspective and further trials are mandatory to address the current areas of discordant results. [ABSTRACT FROM AUTHOR]

The practice of exposing honeybees to pesticides by bee-keepers or via agricultural crops, is one of the ways in which honey becomes contaminated with pesticides. Though honey has many health advantages, however, human exposure to pesticides via consumption of honey has generated public health concerns due to their endocrine-disruptive abilities. Thus, this study evaluated human exposure to endocrine-disrupting pesticides in honey from Nigeria to establish the safety of honey consumed in Nigeria. Honey were analyzed for pesticides using a gas chromatograph combined with an electron capture detector. The concentrations of ∑20 OCPs and ∑14 OPPs in the honey ranged from 0.45-1045 ng/g and 1.13-632 ng/g respectively. The values of both individual and cumulative non-carcinogenic and carcinogenic risks for humans were <1 and 1 × 10−4 respectively suggesting that there are no potential health risks via the honey consumption. The source analysis showed that pesticides in these honey originated from historical and recent/fresh use. [ABSTRACT FROM AUTHOR]

Dietary supplements are drastically growing as a category of consumer products all over the world. The abuse of supplements marketed for slimming purposes and physical fitness has been observed worldwide in recent years, which raises concerns in terms of public health. In this study, different types of dietary supplements marketed and delivered through the e-commerce were studied for the determination of thallium as a hazardous inorganic contaminant. The total content of thallium was determined by a sensitive voltammetric method after a microwave-assisted oxidative digestion of the sample. In addition, a comparative spectrometric method was applied for validation of the results in the samples. The maximum concentration found for thallium was found to be 2.89 mg kg−1, which well agree with the comparative measurement. Considering the 32 studied formulations, it can be pointed out that ∼24% of the of dietary supplements presented Tl concentrations at concentrations higher than 1 mg kg−1. The results permitted the assessment of the health risk related to thallium from contaminated samples, based on the calculation of the estimated daily intake (EDI) and the risk quotient (HQ). The highest daily intake of thallium was calculated as 82.0 µg day−1 in a protein-based supplement, which is equivalent to an EDI of 1.17 µg kg−1 day−1. This work highlights the need to develop regulations on the limits of toxic elements such as thallium in widely consumed dietary supplements, as well as an in-depth look at the adverse effects caused by this element in the human body. [ABSTRACT FROM AUTHOR]

Electronic waste (e-waste) dismantling facilities are well-known bisphenol chemical (BP) sources. In this study, non-targeted screening combined with targeted analysis of BPs in surface soil from e-waste dismantling facilities and their surroundings revealed their presence, distribution, and exposure risk. A total of 14 BPs were identified including bisphenol A (BPA) and its novel structural analogs and halogenated BPs. The total concentrations of BPs ranged from 963 to 47,160 ng/g (median: 6970 ng/g) in e-waste soil, higher than those measured in surface soil from surrounding areas, i.e., 10–7750 ng/g (median 197 ng/g). BPA, tetrabromobisphenol A (TBBPA), and bisphenol F (BPF) were the dominant ones from the two areas. Concentrations of TBBPA and its debromination product from the surrounding area significantly decreased with increasing distances from the e-waste dismantling facilities. Estimation of daily intake via oral ingestion of soil suggests that current contamination scenarios are unlikely to pose health risks for e-waste dismantling workers and adults and toddlers living in the surrounding areas, with their intakes generally well below the tolerable daily intakes proposed for several BPs. However, the BPA intakes of workers exceeded the more strict tolerable daily intake for BPA established recently, which merits continuous environmental surveillance. [ABSTRACT FROM AUTHOR]

This paper presents the first assessment of dietary exposure to aflatoxin M1 (AFM1) and associated health risks through milk and dairy product consumption in Armenia. Data on AFM1 in raw milk were obtained from an annual residue monitoring program. Additionally, commonly consumed dairy products (pasteurized milk, cheese, sour cream, curd cheese) were sampled, considering the sources of raw milk used by dairy companies. Per capita consumption of raw milk was sourced from national food balance databases, while individual consumption data for dairy products was collected via a 24 h recall survey with 1400 adult respondents. Detectable levels of AFM1 were observed in 7.14% of raw milk samples (up to 0.334 μg/kg) and, albeit at lower amounts (up to 0.009 µg/kg), in 30% and 40% of sour cream and curd cheese, respectively. The AFM1 levels were lower than the national maximum permitted level (0.5 μg/kg); however, levels in raw milk exceeded the EU ML (0.05 μg/kg). The estimated margin of exposure values for dairy products indicated no significant risk, whereas a reasonable worst-case estimate, using the measurable levels of AFM1 in raw milk consumption indicated a potential public health concern. This study provides a scientific basis for evaluating aflatoxin issues in the Caucasus area. [ABSTRACT FROM AUTHOR]

Diet–drug interactions (DDIs) are pivotal in drug discovery and pharmacovigilance. DDIs can modify the systemic bioavailability/pharmacokinetics of drugs, posing a threat to public health and patient safety. Therefore, it is crucial to establish a platform to reveal the correlation between diets and drugs. Accordingly, we have established a publicly accessible online platform, known as Diet-Drug Interactions Database (DDID, https://bddg.hznu.edu.cn/ddid/), to systematically detail the correlation and corresponding mechanisms of DDIs. The platform comprises 1338 foods/herbs, encompassing flora and fauna, alongside 1516 widely used drugs and 23 950 interaction records. All interactions are meticulously scrutinized and segmented into five categories, thereby resulting in evaluations (positive, negative, no effect, harmful and possible). Besides, cross-linkages between foods/herbs, drugs and other databases are furnished. In conclusion, DDID is a useful resource for comprehending the correlation between foods, herbs and drugs and holds a promise to enhance drug utilization and research on drug combinations. [ABSTRACT FROM AUTHOR]

Plastic contamination is widely recognized as a major environmental concern due to the entry of small plastic particles into the food chain, thereby posing potential hazards to human health. However, the current understanding of microplastic (MP; < 5 mm) particles in livestock, which serve as an important food source, is limited. This study aims to investigate the concentration and characteristics of MPs in edible tissues of cow and sheep, namely liver, meat, and tripe, obtained from butcher shops in five areas of Bushehr port, Iran. The mean concentration of MPs in different tissues of cow and sheep were 0.14 and 0.13 items/g, respectively. Among the examined tissues, cow meat exhibited the highest concentration of MPs, with a concentration of 0.19 items/g. Nylon and fiber were identified as the predominant polymer types and shapes of MPs found in cow and sheep tissues, respectively. Furthermore, no statistically significant difference was observed in MP concentration across different tissues of cow and sheep. Significantly, this study highlights the elevated hazards associated with exposure to MPs through the consumption of edible cow and sheep tissues, particularly for children who consume meat. The results underscore the potential transfer of MPs from the environment to livestock bodies through their food, contamination during meat processing, and subsequent health hazards for consumers. [ABSTRACT FROM AUTHOR]

Breast milk holds an immense nutritional value as it contains health-promoting substances in a unique, optimal form. Additionally, breast milk's significance extends to health and environmental protection, as it serves as an indicator of both maternal and infant exposure. In this study, breast milk samples collected in 2013 and in 2014–2016 from mothers in Vienna (Austria) were analysed for polybrominated diphenyl ethers (PBDE) and per- and polyfluoroalkyl substances (PFAS), as well as further substances which have been listed under the Stockholm Convention on Persistent Organic Pollutants (POPs) due to their persistent, bioaccumulative and toxic properties. The total concentration of the PBDE congeners in the samples (n = 18, sampled 2013) ranged from 0.055 to 52 ng/g lipid, and from 0.002 to 2.5 ng/g breast milk. In the pooled sample, the sum of PBDEs was detected at a level of 4.4 ng/g lipid. Based on the 2014–2016 study population, certain PFAS were detected in all samples (n = 40). Exposure to the sum of four specific PFAS including perfluorooctanesulphonate (PFOS), perfluorooctanoic acid (PFOA), perfluoro-n-nonanoic acid (PFNA) and perfluoro-1-hexanesulfonate (PFHxS) ranged between 0.014 and 0.12 ng/L breast milk. In the pooled sample, PFOS and PFOA were found in concentrations of 0.025 ng/g and of 0.045 ng/g, respectively. In addition, the first generation of POPs, mainly organochlorine compounds, was measured in a pooled sample of breast milk from participants sampled in 2014–2016 as part of the WHO/UNEP breast milk monitoring program and compared to the POPs measured in pooled samples collected in 1987/1988 and 1992/1993, respectively. Therefore, this paper demonstrates the effectiveness of the Stockholm Convention on POPs by comparing the Austrian results from the WHO/UNEP global breast milk study from 1987 to 2016. However, the data also show that, despite these reductions, health-relevant levels are still being reached, particularly in terms of children's health when the presence of the new generation of POPs, such as PBDEs and PFAS, in human breast milk is taken into account. [ABSTRACT FROM AUTHOR]

Fructans can be considered as part of the group of fermentable oligo-, di- and monosaccharides and polyols (FODMAPs). Short-chain fructans have a rapid fermentation rate and can thus worsen symptoms in patients with irritable bowel syndrome. In this study, the fructan content in 40 of the most commonly consumed foods in Slovenia was measured. Overall, the fructan content was relatively low: 0.1–1.97 g/100 g fresh weight. The highest fructan content was found in onion (1.97 g/100 g), followed by wheat flour (0.75 g/100 g). A simple model for calculating fructan intake was developed based on the results of the SI. Menu 2017/2018 national survey, which collected data on the frequency of intake of different foods and food groups (expressed in g/day). After calculating the daily intake of the surveyed foods, we used our results on fructan content to estimate daily fructan consumption. Mean daily fructan intake reaches 1.6–1.7 g/day, with no differences between men and women. Our assessment of fructan intake at the national level represents the first step toward the creation of a database on FODMAP intake.

Breast milk holds an immense nutritional value as it contains health-promoting substances in a unique, optimal form. Additionally, breast milk’s significance extends to health and environmental protection, as it serves as an indicator of both maternal and infant exposure. In this study, breast milk samples collected in 2013 and in 2014–2016 from mothers in Vienna (Austria) were analysed for polybrominated diphenyl ethers (PBDE) and per- and polyfluoroalkyl substances (PFAS), as well as further substances which have been listed under the Stockholm Convention on Persistent Organic Pollutants (POPs) due to their persistent, bioaccumulative and toxic properties. The total concentration of the PBDE congeners in the samples (n = 18, sampled 2013) ranged from 0.055 to 52 ng/g lipid, and from 0.002 to 2.5 ng/g breast milk. In the pooled sample, the sum of PBDEs was detected at a level of 4.4 ng/g lipid. Based on the 2014–2016 study population, certain PFAS were detected in all samples (n = 40). Exposure to the sum of four specific PFAS including perfluorooctanesulphonate (PFOS), perfluorooctanoic acid (PFOA), perfluoro-n-nonanoic acid (PFNA) and perfluoro-1-hexanesulfonate (PFHxS) ranged between 0.014 and 0.12 ng/L breast milk. In the pooled sample, PFOS and PFOA were found in concentrations of 0.025 ng/g and of 0.045 ng/g, respectively. In addition, the first generation of POPs, mainly organochlorine compounds, was measured in a pooled sample of breast milk from participants sampled in 2014–2016 as part of the WHO/UNEP breast milk monitoring program and compared to the POPs measured in pooled samples collected in 1987/1988 and 1992/1993, respectively. Therefore, this paper demonstrates the effectiveness of the Stockholm Convention on POPs by comparing the Austrian results from the WHO/UNEP global breast milk study from 1987 to 2016. However, the data also show that, despite these reductions, health-relevant levels are still being reached, particularly in terms of children’s health when the presence of the new generation of POPs, such as PBDEs and PFAS, in human breast milk is taken into account.

Plastics and microplastics (MPs) are toxic, pervasive and threatening the biotic and abiotic components of the earth, and they threaten food safety and food security by moving in the food chain. In this study, the amounts and characteristics of 40 table salt samples with different brands, including sea salt (No = 13), rock (No = 13), bulk (No = 8) and non-standard (No = 6), were investigated with a combination of sieving, filtration, observation and FTIR, Micro-Raman and SEM techniques. The results showed that all the salts were contaminated with MPs. In general, the abundance range of detected particles was 700–5470 MPs/kg. The abundance of MPs was higher in counterfeit and non-standard salts (1825 ± 1808 MPs/kg). Investigating the relationship between the effect of the purification process (Kruskal-Wallis Test, P = 0.841), the type of packaging (Kruskal-Wallis Test, P = 0.609), and the type of salt (Kruskal-Wallis Test, P = 0.942), on the abundance of MPs using a comparison test Kruskal-Wallis was not significant. However, the numerical difference was recognizable. The most identified polymer in the salts was cellulose acetate, which probably causes by unmanaged plastic litter in the environment (especially cigarette butts). The dominant form of particles was fragment-shaped, which is the most abundant form of identified MPs in the environment. Both environmental pollution and secondary pollution (during production and packaging), respectively, contribute to the contamination of salts with MPs. The estimated human dietary intake (EDI) and the amount of estimated annual intake (EAI) for different ages in Iran were obtained EDI = 5–59 MPs/capita/day and EAI = 1967–21563 MPs/capita/year. The surface morphology of the particles showed that the MPs were affected by continuous weathering, mechanical fracture and oxidation. MPs are a threat to human health due to the absorption and transmission of dangerous pollutants and their inherent toxicity. Therefore, a solution must be thought of to prevent the contamination of the food chain through salts by MPs, (with protective measures at the salt source, and by improving its production processes.

Background: Nutritional intake problems are common among santries due to a lack of varied balanced nutritional menus, which impacts nutritional status. As a result, menu modifications are required to improve santries nutritional status. Objectives: Creating a balanced nutritional menu and understanding the relationship between daily intake and nutritional status of the santries. Methods: Using mixed methods quantitatively and experimentally. The research subjects used a quota sampling of 25 santries as well as untrained panelists and 15 semitrained panelists, namely nutrition students who were experienced in organoleptic testing. Intake data from 2x24 hour food recall and nutritional status data from anthropometric measurements. The development of a balanced nutritional menu is adjusted to the results of monitoring and filling out questionnaires regarding preferences for food ingredients. Data analysis uses the Spearman test to determine the relationship between variables. Results: There is a relationship between energy intake (p-value = 0.050), protein intake (p-value = 0.005), and fat intake (p-value = 0.018) and student nutritional status; however, there is no relationship between carbohydrate intake (p-value = 0.188). The santries's fiber intake is still below the Nutritional Adequacy Rate, and the rainbow tofu hotpot is the result of developing a balanced nutritional menu that the santries enjoy the most. Conclusions: The nutritional status of santries's related to their energy, protein, and fat intake. There is no link between carbohydrate intake and student nutritional status. "Rainbow Tofu Hotpot" is a nutritionally balanced menu that santries prefer in terms of color, taste, aroma, and texture. [ABSTRACT FROM AUTHOR]

Acetamiprid (ACE) and imidacloprid (IMI) are insecticides of global importance and are used as spray and watering agents for ornamental plants to control biting and sucking insects or as topical medications on pets to remove and control fleas. Human biomonitoring data on ACE and IMI exposures when applying these products are limited. We investigated exposures to ACE and IMI in male volunteers after the domestic application of either an ACE-containing agent or an IMI-containing spot-on medication. Complete and consecutive urine samples were collected for up to 56 h after application. Urine samples were analyzed for ACE, IMI, and their respective metabolites (N-desmethyl-ACE, IMI-olefin, and sum of 4−/5-hydroxy-IMI) by liquid chromatography–tandem mass spectrometry. Fairly uniform concentrations of N-desmethyl-ACE could be observed before and after orchid treatment, so that an ACE exposure associated with orchid treatment can most likely be excluded. In contrast, after the application of the IMI-containing medication, elevated concentrations of IMI, 4−/5-hydroxy-IMI, and IMI-olefin were quantified in urine samples post-20 h with maximum concentrations of 3.1, 14.9, and 8.0 μg/g creatinine, respectively, well above general background levels. Nevertheless, the IMI intake (10.6 μg/kg bw), calculated from the excreted amounts, was around five times below the current European acceptable daily intake. Based on the case results here, household exposures to ACE and IMI after spray treatment of ornamental plants and anti-flea treatment of dogs can be regarded as low and safe. However, people regularly applying neonicotinoid-containing formulations, such as professional gardeners and employees in animal shelters, should be studied in more detail.

In recent years, there has been a growing concern about the negative impact of unforeseen contaminants such as metals in commonly consumed food items, which pose a threat to human well-being. Therefore, it is of utmost importance to evaluate the levels of these contaminants to guarantee the safe consumption of these food items. The goal of the current research is to determine the levels of essential (EMs: Mg, Ca, Mn, Fe, Co, Cu, and Zn) and potentially toxic metals (PTMs: Al, Cr, Ni, As, Cd, and Pb) in various brands of wheat-based sweets. One hundred samples were collected and analysed via flame atomic absorption spectrometry (FAAS) and inductively coupled plasma–optical emission spectrometry (ICP-OES). Also, the current study was to investigate the distribution, correlation, and multivariate analysis of 13 metals (Mg, Ca, Mn, Fe, Co, Cu, Zn, Al, Cr, Ni, As, Cd, and Pb). Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were used to interpret the metals' association. The concentration (mg/kg) ranges of EMs were, in order, Mg (12.70–65.67), Ca (24.02–209.12), Mn (1.32–9.61), Fe (4.55–111.23), Co (0.32–8.94), Cu (2.12–8.61), and Zn (2.60–19.36), while the concentration (mg/kg) ranges of PTMs were, in order, Al (0.32–0.87), Cr (0.17–5.74), Ni (0.36–1.54), Cd (0.16–0.56), and Pb (0.14–0.92), and As was not detected in any sample under investigation. The HCA data revealed that Co, Al, and Ni form clusters with other metals. Sweets are prepared at high temperatures, and the elevated temperatures can increase the likelihood of Ni and Al leaching from stainless steel. Tolerable dietary intake (TDI) values for Ni were higher than the values established by the European Food Safety Authority (EFSA). The CR value found for the Ni and Cr was at the threshold level of cancer risk, if an amount of 25 g were to be used over a lifetime. In a nutshell, this study highlights the monitoring of EM and PTM levels in wheat-based sweets, and from a food safety perspective, the study is important for consumers of wheat-based sweets. [ABSTRACT FROM AUTHOR]

Medicinal plants and herbs are commonly used for preparing teas as water infusions but they may be contaminated with environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). The aim of the study was to assess the contamination levels of polycyclic aromatic hydrocarbons in dried herbal teas and their transfer into water infusions. The PAHs concentrations were determined in dried tea from five plant species: Matricaria chamomilla L., Thymus serpyllum L., Tilia tomentosa Moench, Sambucus nigra L. and Achillea millefolium L. Dried herbal teas from different commercial brands were purchased from Bulgarian markets. Detection of PAHs was performed using gas chromatography coupled with mass spectrometry (GC–MS). In dried tea samples, PAHs with 3 and 4 aromatic rings were predominant with a contribution over 79%, whereas 5–6 rings PAHs were not detected. Benzo[a]pyrene was found below the limit of detection both in dried teas and their water infusion. The results showed white yarrow as the least contaminated herbal tea, while teas made of Tilia tomentosa Moench (linden) were more polluted (mean total content of 13 PAHs—274 µg/kg dw). The mean content of PAHs in infusions ranged from 185 to 478 ng/L (in white yarrow and linden teas, respectively). The mean transfer rates of sum 13 PAHs from dried herbs into water infusions were found in the range 15.4–56.7%. The potential health risk by tea consumption was assess by evaluation of daily intake of PAHs. [ABSTRACT FROM AUTHOR]

The objective of this work was to evaluate the concentrations of essential metals (K, Na, Ca, Mg, Fe, Cu, Se, B, P, and Zn) and potential health risks in chicken giblets commonly sold to consumers in Lokoja's main market, Kogi State, Nigeria. Using appropriate standard methods, samples were digested with 65% HNO3, and the digest was analyzed using an Inductively Coupled Plasma-Optical Emission Spectrometer. The mean concentrations (mg/kg) in gizzard ranged from 0.06±0.08 (Cu) to 28.1±6.9 (P), kidney 0.04±0.01 (Cu) to 24±10 (P), and liver 0.09±0.10 (Cu) to 47±11(P). All the essential metals examined were below the FAO and WHO's permissible standards. The observed trend in the accumulation of metal concentration in chicken giblets was P > Na > Ca > Fe > Mg > Zn > B > Se > K, Cu. The health risk analyses revealed that the current exposure levels will not have a major negative impact on human health, as the hazard quotient for each metal was less than one (<1) and the overall hazard index was also less than 1. Although the population will not be exposed to the potential health risks from these metals presently, there is a need to regularly assess the levels of heavy metals in chicken giblets to maintain protection against negative health effects. [ABSTRACT FROM AUTHOR]

One of the primary environmental routes through which humans are exposed to metals and may be exposed to health risks is the food chain's contamination with heavy metals. The study observed the risks posed by contaminants in vegetables produced in soil that received wastewater irrigation, as well as their origins and the human health impacts. Eight harmful metals (Cu, Fe, Zn, Mn, Pb, Cd, Ni, and Cr) were tested for concentration levels in water, soil, and vegetable samples using analytical techniques and an atomic absorption spectrophotometer. The present study investigated the potential health implications associated with the consumption of vegetables irrigated using wastewater containing heavy metals. The results indicated a notable accumulation of heavy metals in plant and soil samples obtained from Kirri Shamozai, Pakistan. In comparison to vegetables cultivated in soil irrigated with fresh water, the concentration levels of heavy metals in vegetables grown on soil irrigated with untreated wastewater were considerably higher at (P ≤ 0.001) and above the World Health Organization (WHO) recommended limits. The results showed that heavy metals had significantly accumulated in the soil and had permeated into the crops. Heavy metal concentrations in vegetables cultivated on land irrigated with wastewater were more significant than those grown on land irrigated with freshwater. They exceeded US EPA and World Health Organization (WHO) limits. PCA results for Pb, Cu, and Cr are the main issues impacting water quality and health hazards. The PCA results show that the soil has an extensive loading of heavy metals Cd, Ni, and Mn. [ABSTRACT FROM AUTHOR]

Selenium is part of the active site of glutathione peroxidase, thioredoxin reductase, and iodothyronine deiodinase and plays an important role in thyroid hormone metabolism. Adequate selenium intake protects the body from free radical damage, supports the immune system, maintains healthy thyroid function, and may help with diseases associated with free radical damage and inflammation. The aim of this work was to estimate the average daily selenium intake in the different food groups of Macedonian population. The aim of this work was to estimate the average daily selenium intake in the Macedonian population by multiplying the average selenium concentration in each food group (meat, fish, milk and dairy products, vegetable and fruit, nuts and cereal based samples), determined by microwave digestion followed by electrothermal atomic absorption spectroscopy (ETAAS), by the daily food intake per person. These calculations were based on a planned adult diet with accepted criteria and standards for energy, nutrients, and protective substances as recommended by the World Health Organization (WHO). An average daily selenium intake of 36 µg/day was determined, with a range of selenium intake of 33 - 39 µg/day at an average adult energy value of 3,000 kcal, which is below the RDA of 55 µg/day. This is likely due to consumption of higher energy foods that contain more fat, free sugars, and salt, but not enough micronutrients. Daily selenium intakes for children aged 1 - 3 years, 4 - 6 years, and 7 - 15 years average 19 µg/day, 28 µg/day, and 37 µg/day, respectively. These values are consistent with the recommended daily selenium intake for children, which is 20 µg/day, 30 µg/day, and 40 µg/day, respectively. These results are due to the fact that milk and dairy products, meat and fish are more common in children's diets, while bread and cereal products are less common. From the obtained results, it can be concluded that the selenium content in foods of Macedonian origin is relatively low; therefore, the daily selenium intake for adults is below the RDA. On the other hand, the daily selenium intake for children reaches the RDA due to the higher proportion of milk and meat in the diet. It should also be kept in mind that good sources of selenium cannot be identified only on the basis of high selenium concentration, but the bioavailability of Se in foods must also be considered. Selenium supplementation is recommended to compensate for nutritional deficiencies and to prevent various diseases associated with Se deficiency, but only under medical supervision. [ABSTRACT FROM AUTHOR]

Background: Copper (Cu) and zinc (Zn) are essential nutrients that must be maintained at adequate levels in the human body in order to make physiological functions normal and sustainable. Rice is a leading staple cereal crop which can be the main source of Cu and Zn in the diet. Results: Here, we aimed to investigate Cu and Zn concentrations in rice with corresponding soil influencing factors and to assess the dietary intake of Cu and Zn from rice consumption by residents of major rice producing regions. A total of 712 rice grain and 90 paired soil–rice samples were collected from September to November 2015 covering eleven provinces across China. Average Cu and Zn concentrations were 27.2 and 69.1 mg kg−1, respectively, in soils, and 1.98 and 12.3 mg kg−1 in rice. The concentrations and bioconcentration factors (BCFs) of Cu and Zn followed the sequence: roots > shoots > grains. Soil pH, cation exchange capacity (CEC), and soil organic carbon (SOC) play important roles in rice Cu and Zn uptake with negative effects. The average Cu and Zn intakes from rice consumption were 0.597 and 3.68 mg day−1, respectively. Conclusions: The status of Cu and Zn daily intake from rice consumption were fully adequate but there remained some sampling sites where Zn intake for males and Cu intakes were deficient at 1.40%, indicating that local residents need to maintain their dietary nutrient requirements. [ABSTRACT FROM AUTHOR]

Polycyclic aromatic hydrocarbons (PAHs) are stable organic pollutants with proven carcinogenic properties. These substances produced as a result of incomplete burning of fossil fuels. Due to PAHs importance in people's health, we decided to design a study to measure the amount of polycyclic aromatic hydrocarbons (PAHs) in different types of traditional bread produced in Tehran city and calculate their daily intake by consumers. Seventy-five samples of five types of bread including Lavash, Tafton, Sangak, and Barbary and bulk were randomly collected from bakeries in the city of Tehran to investigate the amount of PAHs. All extracted samples were measured by Gas chromatography–mass spectrometry (GC-MS). The separation of PAHs performed based on a solid phase magnetic extraction (MSPE) method with carbon nanotubes prepared from bread samples and the extracted samples were measured by GC-MS. Our finding showed that the mean values of aromatic hydrocarbon compounds (PAH) in the bread samples range from 0.2 to 8.7 μg kg-1. The maximum amount of aromatic hydrocarbon compounds (PAH) was in Barbary bread with amount of 8.7 µg kg−1 and the minimum value was in industrial bread (bulk) with 0.2 µgkg−1. Also, the mean value ofPAHs content in Sangak, lavash, and bulk (industrial) bread was 2.25, 2.5 and 1.66 µg kg−1, respectively. The highest and lowest mean value of aromatic hydrocarbon polycyclic compounds (PAHs) were obtained in barbaribread around 2.64 μg kg−1 and 1.59 μg kg-1 in Taftoon, respectively. Also,the result of this study showed that the Daily intake of benzopyrene in bread by consumers was below international recommended levels. According to the results, long time and high-temperature baking, also the thickness of the bread, is the main contributor of high concentration of PAHs in the bread. [ABSTRACT FROM AUTHOR]

Electronic waste (e-waste) dismantling facilities are well-known bisphenol chemical (BP) sources. In this study, non-targeted screening combined with targeted analysis of BPs in surface soil from e-waste dismantling facilities and their surroundings revealed their presence, distribution, and exposure risk. A total of 14 BPs were identified including bisphenol A (BPA) and its novel structural analogs and halogenated BPs. The total concentrations of BPs ranged from 963 to 47,160 ng/g (median: 6970 ng/g) in e-waste soil, higher than those measured in surface soil from surrounding areas, i.e., 10–7750 ng/g (median 197 ng/g). BPA, tetrabromobisphenol A (TBBPA), and bisphenol F (BPF) were the dominant ones from the two areas. Concentrations of TBBPA and its debromination product from the surrounding area significantly decreased with increasing distances from the e-waste dismantling facilities. Estimation of daily intake via oral ingestion of soil suggests that current contamination scenarios are unlikely to pose health risks for e-waste dismantling workers and adults and toddlers living in the surrounding areas, with their intakes generally well below the tolerable daily intakes proposed for several BPs. However, the BPA intakes of workers exceeded the more strict tolerable daily intake for BPA established recently, which merits continuous environmental surveillance.

This paper presents the first assessment of dietary exposure to aflatoxin M1 (AFM1) and associated health risks through milk and dairy product consumption in Armenia. Data on AFM1 in raw milk were obtained from an annual residue monitoring program. Additionally, commonly consumed dairy products (pasteurized milk, cheese, sour cream, curd cheese) were sampled, considering the sources of raw milk used by dairy companies. Per capita consumption of raw milk was sourced from national food balance databases, while individual consumption data for dairy products was collected via a 24 h recall survey with 1400 adult respondents. Detectable levels of AFM1 were observed in 7.14% of raw milk samples (up to 0.334 μg/kg) and, albeit at lower amounts (up to 0.009 µg/kg), in 30% and 40% of sour cream and curd cheese, respectively. The AFM1 levels were lower than the national maximum permitted level (0.5 μg/kg); however, levels in raw milk exceeded the EU ML (0.05 μg/kg). The estimated margin of exposure values for dairy products indicated no significant risk, whereas a reasonable worst-case estimate, using the measurable levels of AFM1 in raw milk consumption indicated a potential public health concern. This study provides a scientific basis for evaluating aflatoxin issues in the Caucasus area.

The objective of this work was to evaluate the concentrations of essential metals (K, Na, Ca, Mg, Fe, Cu, Se, B, P, and Zn) and potential health risks in chicken giblets commonly sold to consumers in Lokoja's main market, Kogi State, Nigeria. Using appropriate standard methods, samples were digested with 65% HNO3, and the digest was analyzed using an Inductively Coupled Plasma-Optical Emission Spectrometer. The mean concentrations (mg/kg) in gizzard ranged from 0.06±0.08 (Cu) to 28.1±6.9 (P), kidney 0.04±0.01 (Cu) to 24±10 (P), and liver 0.09±0.10 (Cu) to 47±11(P). All the essential metals examined were below the FAO and WHO's permissible standards. The observed trend in the accumulation of metal concentration in chicken giblets was P > Na > Ca > Fe > Mg > Zn > B > Se > K, Cu. The health risk analyses revealed that the current exposure levels will not have a major negative impact on human health, as the hazard quotient for each metal was less than one (

Siloxanes and synthetic musk compounds (SMCs) have been widely used as additives in household and personal care products. Humans are easily exposed to siloxanes and SMCs originating from these products through ingestion and dermal absorption of indoor dust. In the present study, indoor dust samples were analyzed for 19 siloxanes (cyclic and linear) and 12 SMCs (polycyclic, macrocyclic, and nitro musks) to assess their occurrence, time trends over time, source, and health risks. A total of 18 siloxanes and 10 SMCs were detected in all indoor dust samples obtained from 2011⎯2021, indicating widespread and long-term contamination. Higher detection frequencies and concentrations were associated with siloxanes and SMCs with higher use and strong resistance against degradation processes. Indoor dust samples were dominated by linear siloxanes (L11–L13), 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(g)-2-benzopyran (HHCB), musk ketone (MK), and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (AHTN). The frequent use of household and personal care products is likely an important source of siloxane and SMC contamination in indoor environments. The concentrations of siloxanes and SMCs in indoor dust increased from 2011 to 2021, particularly, those of linear siloxanes, reflecting the impact of regulatory actions addressing cyclic siloxanes. The profiles of siloxanes remained stable throughout the study period, whereas those of SMCs shifted from nitro to polycyclic musks. The estimated daily intakes (EDIs) of siloxanes and SMCs arising from ingestion were greater than from dermal absorption of indoor dust. The EDIs of siloxanes and SMCs associated with indoor dust indicated that children are exposed to these pollutants.

Due to toxicities, capacities for long-range transportation, bioaccumulation, and biomagnification, mercury (Hg) presents a unique concern to wildlife in remote ecosystems, including “the roof of the world”. Large carnivorous predators are thought to be exposed to elevated Hg due to their high trophic positions, but the direct assessment for Hg contamination is a challenge. Given the poorly understood Hg exposure in these carnivores, establishing a reliable and straightforward assessment would be essential to identify targeted species at Hg exposure risk for effective conservation, particularly in fragile biodiversity hotspots. Small mammals are abundant and serve as prey for large top predators. Combined with local observations, we provided an assessment to estimate the daily Hg exposure via consumption of small mammals for large carnivorous mammals recorded in the Hengduan Mountains, a world biodiversity hotspot, China. Within an altitude span from 2043 to 4251 m a.s.l., the average topsoil total mercury concentration (hereafter [THg]) was 44.65 ± 25.80 μg/kg (mean ± sd; 10.54 – 135.15 μg/kg, n = 41), while the hair [THg] in small mammals was 104.66 ± 91.96 μg/kg (mean ± sd; 7.73 to 385.70 μg/kg, n = 13). Furthermore, the daily intake of Hg was calculated among the 22 investigated/historical-recorded carnivore mammals belonging to 5 families. We found a large variance in daily intake of Hg via small mammals: Felidae (median: 205.93 μg/day) > Ursidae (135.02 μg/day) > Canidae (92.92 μg/day) > Viverridae (19.88 μg/day) > Mustelidae (7.18 μg/day). Specifically, Tiger Panthera tigris was found with the highest Hg daily intake (1701.39 μg/day) via consuming small mammals, while species belonging to Mustelidae generally have low Hg daily intake (

China has relatively high indoor contamination of nicotine, according to recent publications. Therefore, nicotine exposure risks for sensitive populations such as pregnant women in China are of concern. The variability of its internal exposure levels across three trimesters among pregnant women is not well documented. Factors related with nicotine exposure across pregnancy and its associations with oxidative stress markers are also understudied. Based on a birth cohort, we measured concentrations of cotinine (a major metabolite of nicotine) and oxidative stress markers including 8-OHdG, 8-OHG, and HNE-MA in urine samples collected at three trimesters from 1,155 pregnant women enrolled between January 2014 and June 2017 in Wuhan, China. The variability of urinary cotinine across the trimesters, potential factors associated with it, as well as the relationships between urinary cotinine and oxidative stress markers were assessed in pregnant women with cotinine concentrations of < 50 ng/mL (the cutoff value to distinguish smokers and non-smokers). Urinary specific gravity adjusted median concentrations of cotinine (ng/mL) in the entire pregnancy, first, second, and third trimester were 3.04, 3.32, 3.36, and 2.50, respectively, which exhibited fair reliability (intraclass correlation coefficient: 0.47) across pregnancy. Most participants had an estimated daily intake of nicotine higher than the acceptable value (100 ng/kg-bw/day) recommended by the UK and the USA. Maternal age, education level, pre-pregnancy body mass index, and sampling seasons were related to urinary concentrations of cotinine. After adjusting for confounding factors, significant positive relationships (β; 95% confidence interval) were observed between urinary cotinine concentrations and 8-OHdG (0.28; 0.25, 0.30), 8-OHG (0.27; 0.25, 0.29), and HNE-MA (0.27; 0.21, 0.32), respectively (p < 0.01). These results lend insight into the major factors associated with nicotine exposure of pregnant women at environmentally relevant levels and its potential effect on oxidative stress with a large sample size, and warrant the necessity of reducing the exposure in sensitive populations. [ABSTRACT FROM AUTHOR]

Water, forages, and soil contamination with potentially toxic metals (PTMs) through anthropogenic activities has become a significant environmental concern. It is crucial to find out the level of PTMs in water, soil, and forages near industrial areas. The PTMs enter the body of living organisms through these sources and have become a potential risk for humans and animals. Therefore, the present study aims at the health risk assessment of PTMs and their accumulation in soil, water, and forages of three tehsils (Kallar Kahar, Choa Saidan Shah, and Chakwal) in district Chakwal. Samples of wastewater, soil, and forages were collected from various sites of district Chakwal. PTMs detected in the present study were cadmium (Cd), chromium (Cr), lead (Pb), zinc (Zn), cobalt (Co), copper (Cu), and nickel (Ni), and their levels were measured through atomic absorption spectrophotometer (AAs GF95 graphite furnace auto sampler). Pollution load index (PLI), bio concentration factor (BCF), soil enrichment factors (EF), daily intake value (DIM), and health risk index (HRI) in sheep, cow, and buffalo were also analyzed. The results revealed that the mean concentration (mg/L) of Cd (0.72–0.91 mg/L), Cr (1.84–2.23 mg/L), Pb (0.95–3.22 mg/L), Co (0.74–2.93 mg/L), Cu (0.84–1.96 mg/L), and Ni (1.39–4.39 mg/L) in wastewater samples was higher than permissible limits set by WHO, NEQS, WWF, USEPA, and Pakistan in all three tehsils of district Chakwal. Similarly, in soil samples, concentrations of Cd (1.21–1.95 mg/kg), Cr (38.1–56.4 mg/kg), and Ni (28.3–55.9 mg/kg) were higher than their respective threshold values. The mean concentration of PTMs in forage samples (Parthenium hysterophorus, Mentha spicata, Justicia adhatoda, Calotropis procera, Xanthium strumarium, Amaranthaceae sp.) showed that maximum values of Cd (5.35–7.55 mg/kg), Cr (5.47–7.51 mg/kg), Pb (30–36 mg/kg), and Ni (12.6–57.5 mg/kg) were beyond their safe limit set for forages. PLI, BCF, and EF were > 1.0 for almost all the PTMs. The DIM and HRI for sheep were less than < 1.0 but for cows and buffalo were > 1.0. The current study showed that soil, water, and forages near coal mines area are contaminated with PTMs which enter the food chain and pose significant harm to humans and animals. In order to prevent their dangerous concentration in the food chain, regular assessment of PTMs present in soil, forages, irrigating water, and food is recommended. [ABSTRACT FROM AUTHOR]

The exposure dose of reclaimed water is an important indicator to evaluate the potential risk of water reuse. This study summarized a general calculation model for the exposure dose of reclaimed water, taking into account the three exposure routes of oral intake, skin absorption and inhalation. The differences of reused scenarios, geographical and meteorological conditions, and evaluated populations were considered in the model. The exposure of reclaimed water in practical application was also studied. The daily intakes of reclaimed water of different populations could vary from 0.01 to 49 ​mL. The average annual exposure dose of reclaimed water in the regular reused scenarios was 2444 ​mL. Professional activities (mean was 42.63 ​L and median was 9.81 ​L) had a higher annual exposure dose than non-professional activities (mean was 7.91 ​L and median was 0.90 ​L). Annual exposure doses to road dust reduction, garden greening, road rinse and manual car washing were higher than the average for the professionals. Future research can focus on the exposure risk of reclaimed water of the above activities.

One of the key concerns in public health is food security in the food sector. Due to the large amounts of potentially hazardous metals in wastewater, this practice may pose serious environmental and health risks to neighboring residents. In this study, the health effects of heavy metals in vegetables irrigated with wastewater were studied. The findings indicated a massive accumulation of heavy metals in wastewater-irrigated soil and vegetables collected from Bhakkar, Pakistan. The current study looked at the effects of wastewater irrigation on metal buildup in the soil–plant continuum and the health hazards that come with it (Cd, Co, Ni, Mn, Pb, and Fe). Heavy metal concentrations in vegetables cultivated on soil irrigated with untreated wastewater were not significantly lower (p ≥ 0.05) than in vegetables grown on wastewater-irrigated soil and were below the World Health Organization's recommended limits. A considerable amount of the selected hazardous metals was also swallowed by adults and children who consumed these vegetables, according to the research. On soil that had received wastewater irrigation, Ni and Mn were substantially different at p ≥ 0.001 levels. Pb, Ni, and Cd had health risk scores higher than the ones in all ingested vegetables, while Mn had a health risk score greater than the ones in turnips, carrots, and lettuce. The results also showed that both adults and children who consumed these vegetables absorbed a significant amount of the chosen toxic metals. Pb and Cd were shown to be the most dangerous chemical compounds to human health, and everyday consumption of agricultural plants irrigated with wastewater may pose a health risk, according to the health risk criteria. [ABSTRACT FROM AUTHOR]

To assess the daily intake of total arsenic (tAs) and arsenic speciation and their potential health risks, different food groups, including vegetables, rice, meat, viscera, freshwater fish, and seafood from Chengdu, China were analyzed. The concentrations of tAs ranged from 41.3 to 1185 μg kg−1 with a median of 238 μg kg−1, and 26.0% of tAs in the food groups was of inorganic toxic form. The median concentration of As(V) in rice (184 ± 21.6 μg kg−1) was approximately 2 to 6 times higher than those in other food groups. The bioaccessible inorganic arsenic (iAs) concentrations of the food items obtained from the local markets of Chengdu ranged from 1.07 to 24.6 μg kg−1 (mean of 6.04 μg kg−1). Rice contributed toward the largest amount of daily iAs intake (66.2%). The mean daily iAs intake from vegetable, meat and viscera contributed 10.7%, 12.5% and 6.04% of total iAs intake, respectively. The actual concentration of arsenic in the food exposed to the human body depends on oral bioaccessible fraction. The oral bioaccessibility estimated daily intake (μg kg−1 bw d−1) of tAs and iAs for the residents of Chengdu was 0.32 and 0.16. Health risk assessments carried out based on bioaccessible iAs concentrations showed that the food items were safe for consumption from the iAs perspective. [ABSTRACT FROM AUTHOR]

Bread (Tiry and Samoon), a special and vital bread in a Kurdistan region- Iraq, which people consume daily in their meals. Tiry bread and Samoon contain some macro and micro minerals. Also, consumption of bread is the course of enter the heavy metals into food chain. In this study, wheat and barley flour is used to produce the Tiry bread and Samoon, and some macro and micro minerals in both (wheat and barley) flour and breads that produces them are indicated. In addition, the effect of minerals in bread and Samoon are displayed on human health in a long period. A total of 16 minerals were indicated from breads and flour by Inductive Coupled Plasma (ICP). The highest concentration of Fe, CD, Mn Zn, Cu, and Cr were obtained from barley Turkish flour (28.967, 0.035, 30.723, 20.445, 4.989 and 1.206 mg/kg). Furthermore, the highest V, Mo, B, Ba, and Sb were obtained from TBF (1.713, 1.01, 1.48, 4.038, 0.408 mg/kg). The results of the study showed that the concentration of (Fe, Cd, Mn, Zn, Pb, Se, Ni, Ci, Cr, V, Mo, B, Mg, Ba, Sb and As) in a limited range providing by FAO/WHO. Also, the daily intake and PTWi in some of them are high. but not higher than the range of limitation. [ABSTRACT FROM AUTHOR]

Concentrations of polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) were measured in imported canned fish such as mackerel, sardine and tuna to evaluate the risk relating to human consumption of these products. Gas chromatography-mass spectrometry (GC/MS) was used to evaluate the concentrations of PCBs and PCDD/Fs in the samples. The ∑ 28 PCB concentrations in the canned mackerel, tuna and sardine ranged from 0.33 to 9.48 ng g −1,

This study investigated the total and bioaccessible concentrations of cadmium (Cd) and lead (Pb) in urban soils and their associated human health and ecological risk. Total and bioaccessible metal concentrations were found within the safe limits except for Cd, surpassing the State Environmental Protection Administration (SEPA) China limit in 9.5% of parks. Bioaccessible concentrations were higher in the gastric (G) phase than the intestinal (I) phase, while Cd showed more bioaccessibility compared to Pb. Bioaccessible concentrations reduced Hazard Quotient (HQing) values by 2–22 times and 0–2 times for children and adults, respectively, while hazard index (HI) declined by 1.7 times, and the mean total bioaccessible risk of Pb decreased by 20.8 times. Further, the study revealed a low level of contamination factor (CF < 1) and a low degree of contamination (CD < 6), and Potential Ecological Risk Index (PERI) values for all the cities were less than 150, indicating low ecological risk. [ABSTRACT FROM AUTHOR]

Rice bran is an agro-industrial by-product of low added value that can be used to complement human nutritional needs. In this work, the profile of minerals, fatty acids and amino acids in brown rice bran was determined, aiming to evaluate its potential to complement the nutritional needs of different age groups, according to recommendations of regulatory agencies. The brown rice bran was supplied by a rice processing industry located in the south of the state of Rio Grande do Sul. Minerals were quantified using an emission spectrometer; the fatty acid profile was determined by gas chromatography and the amino acids were quantified by high-performance liquid chromatography with fluorescence (HPLC-FL). The main minerals were phosphorus (P), magnesium (Mg), potassium (K) and calcium (Ca) (2,933, 1,029, 211 and 56 mg / 100 g of rice bran). Saturated, monounsaturated and polyunsaturated fatty acids in rice bran were 22.4, 36.2 and 34.5% of lipid content, respectively. The polar, neutral and charged amino acids represented 8.8, 9.3 and 12.8% of the protein content, respectively. The composition of this co-product of rice supply chain is a good alternative to the new demand on plant-based food supplying the recommended daily intake (RDI) of national and international food polices. [ABSTRACT FROM AUTHOR]

Steroid estrogens (SEs) accumulate in agro-food systems through wastewater treatment and dairy manure, but very little is known about their potential impact on plants and dietary risk to human health. We conducted a meta-analysis to address key questions including, how plants respond to SEs under different environmental conditions, what is the accumulation potential of SEs in distinct plant families, and associated daily dietary intake risks to humans. Based on 517 endpoints, we revealed that various crop species show a heterogeneous response to SEs types (n = 140), SEs concentrations (n = 141), and exposure medium (n = 166). A subsidy-stress response was observed in terms of SEs accumulation for plant growth. The bioaccumulation of SE in plants was shown to be greatest in sand, followed by soil, and hydroponic media. Plants exposed to SEs exhibit considerable changes in physiological and biochemical characteristics. Surprisingly, food crops such as carrot and potato were found as major source of SEs daily intake in food chain but their consequences remains largely unknown. Further field-oriented research is needed to unveil the threshold levels for SEs in soil–plant systems as it may pose a global threat to human health. The state of knowledge presented here may guide towards urgently needed future investigations in this field for reducing the risk in SEs in agro-food systems.

The heavy metals content (HMs) was investigated in 14 different medicinal plants collected from the three regions in Central Serbia, Zlatar, Sokobanja, and Kopaonik. The concentrations of Cd, Cr, Ni, Hg and Pb were determined: Cd (<0.03–2.72 mg/kg); Cr (<0.08–12.1 mg/kg); Ni (<0.08–12.2 mg/kg); Pb (0.6–49.0 mg/kg); the Hg concentration was below the detection limit of 0.06 mg/kg in all samples. The daily intake of HMs due to ingestion of 200 mL of herbal infusion was in all cases below the recommended limit prescribed by the World Health Organization. The estimated daily intake values were below the values for the oral reference dose regulated by the U.S. Environmental Protection Agency (USA EPA). The target hazard quotient and hazard index for Cd, Cr Ni, and Pb were below 1. Nevertheless, due to the tendency of heavy metals to accumulate in the organism, attention should be paid to the daily intake of herbal infusion during long-term usage. Specifically, it is recommended to consume not more than one cup (200 mL) of infusion per day made from thyme (Mt. Zlatar) and blueberry (Mt. Kopaonik), and not more than two cups per day for other herbs. [ABSTRACT FROM AUTHOR]

As an extremely strong polycyclic aromatic hydrocarbon carcinogen, benzo[α]pyrene (BaP) is often produced during food processing at high temperatures. Recently, food safety, as well as toxicity mechanism and risk assessment of BaP, has received extensive attention. We first constructed the database of BaP pollution concentration in Chinese daily food with over 104 data items; collected dietary intake data using online survey; then assessed dietary exposure risk; and finally revealed the possible toxicity mechanism through four comparative molecular dynamics (MD) simulations. The statistical results showed that the concentration of BaP in olive oil was the highest, followed by that in fried meat products. The margins of exposure and incremental lifetime cancer risk both indicated that the dietary exposure to BaP of the participants was generally safe, but there were still some people with certain carcinogenic risks. Specifically, the health risk of the core district population was higher than that of the noncore district in Bashu area, and the female postgraduate group was higher than the male group with bachelor degree or below. From MD trajectories, BaP binding does not affect the global motion of individual nucleic acid sequences, but local weak noncovalent interactions changed greatly; it also weakens molecular interactions of nucleic acid with Bacillus stearothermophilus DNA polymerase I large fragment (BF), and significantly changes the cavity structure of recognition interface. This work not only reveals the possible toxicity mechanism of BaP, but also provides theoretical guidance for the subsequent optimization of food safety standards and reference of rational diet. [ABSTRACT FROM AUTHOR]

Abstract With urbanization, municipal solid waste (MSW) transfer station as an important link in the process of refuse collection and transportation is closer to residents’ living areas. At present, studies on airborne antibiotic resistance genes (ARGs) generated during MSW management are still few and not comprehensive enough. In this study, metagenomics and high-throughput sequencing methods were used to analyze the composition and content of bioaerosol and airborne ARGs in the waste reception hall and the top vent of three MSW transfer stations. 265 ARG subtypes were detected. The main subtypes were bacA, multidrug_transporter, mexW, sul2 and macB, and the main types were multidrug resistance genes and bacitracin resistance genes. Different microbes and ARGs showed diverse release characteristics, but in general, the concentration of bacteria and ARGs at the top vent of the transfer station was higher than that in the waste reception hall, and fungi were more sensitive than bacteria when passing through the odor treatment system connecting between the top vent and the waste reception hall. For ARGs, daily intake of a worker was calculated to be 1.08 × 1010–2.79 × 1010 copies d− 1 and environmental release was 2.88 × 109–9.49 × 109 copies m− 3. Therefore, control measures for airborne ARGs and pathogenic microorganisms are urgently needed to ensure the health of workers and surrounding residents.

[Display omitted] • Data on food levels of polychlorinated naphthalenes (PCNs) have been reviewed. • Most studies has been conducted in China and Europe. • Most reported food levels of PCNs do not suggest potential risks for the consumers. • The available estimated daily intakes of PCNs seem not being of concern. In general, for most environmental persistent organic pollutants (POPs), dietary intake is the main way of exposure. Polychlorinated naphthalenes (PCNs) are a family of two-ringed aromatic compounds, which are ubiquitous environmental contaminants, being structurally similar to PCDD/Fs and PCBs. Although the production and use of PCNs were banned in the USA and Europe some decades ago, due to their persistent properties, PCNs remain still present in the environment, being able to enter the food chain. The present paper was aimed at reviewing the results of the studies focused on determining the levels of PCNs in foods. The human dietary intake of these compounds was also reviewed with the few available data. The information on the levels of PCNs in foodstuffs is currently more abundant than that found in a previous review (Domingo, 2004). Since then, China is the country that has contributed with the greatest number of studies. The results of most surveys seem to suggest that human health risks of PCNs due to dietary exposure should not be worrying. However, because of the important differences in the methodology of the published studies, the comparison of the results is not easy, although there seems to be a general trend towards a decrease in the levels of PCNs in foods. In the next few years, a continued reduction of the environmental levels of PCNs is still expected. Therefore, a direct repercussion of the concentrations of these pollutants in foodstuffs must be also noted. Consequently, a reduction of the dietary exposure to PCNs should be expected. Anyway, to establish the tolerable dietary intake of PCNs is a key issue for assessing human health risks of these pollutants. [ABSTRACT FROM AUTHOR]

One of the primary environmental routes through which humans are exposed to metals and may be exposed to health risks is the food chain’s contamination with heavy metals. The study observed the risks posed by contaminants in vegetables produced in soil that received wastewater irrigation, as well as their origins and the human health impacts. Eight harmful metals (Cu, Fe, Zn, Mn, Pb, Cd, Ni, and Cr) were tested for concentration levels in water, soil, and vegetable samples using analytical techniques and an atomic absorption spectrophotometer. The present study investigated the potential health implications associated with the consumption of vegetables irrigated using wastewater containing heavy metals. The results indicated a notable accumulation of heavy metals in plant and soil samples obtained from Kirri Shamozai, Pakistan. In comparison to vegetables cultivated in soil irrigated with fresh water, the concentration levels of heavy metals in vegetables grown on soil irrigated with untreated wastewater were considerably higher at (P ≤ 0.001) and above the World Health Organization (WHO) recommended limits. The results showed that heavy metals had significantly accumulated in the soil and had permeated into the crops. Heavy metal concentrations in vegetables cultivated on land irrigated with wastewater were more significant than those grown on land irrigated with freshwater. They exceeded US EPA and World Health Organization (WHO) limits. PCA results for Pb, Cu, and Cr are the main issues impacting water quality and health hazards. The PCA results show that the soil has an extensive loading of heavy metals Cd, Ni, and Mn.

In recent years, there has been a growing concern about the negative impact of unforeseen contaminants such as metals in commonly consumed food items, which pose a threat to human well-being. Therefore, it is of utmost importance to evaluate the levels of these contaminants to guarantee the safe consumption of these food items. The goal of the current research is to determine the levels of essential (EMs: Mg, Ca, Mn, Fe, Co, Cu, and Zn) and potentially toxic metals (PTMs: Al, Cr, Ni, As, Cd, and Pb) in various brands of wheat-based sweets. One hundred samples were collected and analysed via flame atomic absorption spectrometry (FAAS) and inductively coupled plasma–optical emission spectrometry (ICP-OES). Also, the current study was to investigate the distribution, correlation, and multivariate analysis of 13 metals (Mg, Ca, Mn, Fe, Co, Cu, Zn, Al, Cr, Ni, As, Cd, and Pb). Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were used to interpret the metals’ association. The concentration (mg/kg) ranges of EMs were, in order, Mg (12.70–65.67), Ca (24.02–209.12), Mn (1.32–9.61), Fe (4.55–111.23), Co (0.32–8.94), Cu (2.12–8.61), and Zn (2.60–19.36), while the concentration (mg/kg) ranges of PTMs were, in order, Al (0.32–0.87), Cr (0.17–5.74), Ni (0.36–1.54), Cd (0.16–0.56), and Pb (0.14–0.92), and As was not detected in any sample under investigation. The HCA data revealed that Co, Al, and Ni form clusters with other metals. Sweets are prepared at high temperatures, and the elevated temperatures can increase the likelihood of Ni and Al leaching from stainless steel. Tolerable dietary intake (TDI) values for Ni were higher than the values established by the European Food Safety Authority (EFSA). The CR value found for the Ni and Cr was at the threshold level of cancer risk, if an amount of 25 g were to be used over a lifetime. In a nutshell, this study highlights the monitoring of EM and PTM levels in wheat-based sweets, and from a food safety perspective, the study is important for consumers of wheat-based sweets.

Macroelements such as Na, K, Ca, and Mg play a significant physiological role, and their inadequate intake has been linked to severe diseases, such as high blood pressure. Data on risk assessment for human health in Serbia, from the intake of these macroelements through the consumption of canned food, are minimal. Therefore, the content of Na, K, Ca, and Mg in five types of canned meat that members of the Serbian Armed Forces regularly use was examined. Macroelements were determined by inductively coupled plasma mass spectrometry in cans of beef goulash, pork ragout, spam, liver pate, and meatballs in tomato sauce, which were stored from one month to six years. The sodium content was significantly higher than the potassium content in all types of food, so the Na/K ratio below 1, desirable for good health, was not found in any of the analyzed products. Also, a significant number of samples had an unfavorable Ca/Mg ratio above 1. However, due to the low consumption of canned food by members of the Serbian Armed Forces, its contribution to the average daily intake of macroelements is almost negligible. The concentration of macroelements decreased with the shelf life, while a significant source of Ka and Mg, among analyzed ingredients, was ground red pepper.

Urinary benzene metabolites trans, trans-muconic acid (t, t-MA), and S-phenyl mercapturic acid (S-PMA) are often used as biomarkers of internal exposure to benzene. However, there are few reports on using urinary benzene metabolites to estimate airborne benzene concentrations in individuals exposed to benzene. In this study, t, t-MA, and S-PMA were analyzed by UPLC-MS/MS, and a simple pharmacokinetic model was used to calculate the daily intake (DI) of benzene based on the levels of urinary t, t-MA, and S-PMA in occupational individuals. The back-calculated airborne benzene levels (BCABL) were obtained from the DI of benzene. Among the exposed subjects (n = 84), the median BCABL (3.67 mg/m3) based on t, t-MA was very close to the median level of measured airborne benzene (3.27 mg/m3, p = 0.171), and there was no effect of smoking or dietary habits on t, t-MA-based BCABL. In the control subjects (n = 49), the levels of measured airborne benzene were all below the quantitation limit (0.024 mg/m3), and the BCABL (0.002–0.25 mg/m3) calculated by S-PMA was close to this background level. Our study suggests that the t, t-MA-based BCABL can reflect the actual airborne benzene level in a range of 1.10–86.91 mg/m3 and that the S-PMA-based BCABL is more reliable for non-professional benzene exposure. [ABSTRACT FROM AUTHOR]

Diet is an important exposure route for phthalates, such as di-iso-butyl phthalate (DiBP), dibutyl phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), and benzyl butyl phthalate (BBP). In this study, we aimed to estimate phthalate exposure in the diet of pregnant women and assess the health risk. A total of 517 pregnant women in the first trimester were recruited, and food frequency questionnaires were collected. A simple distribution assessment method was used to estimate daily exposure, and the hazard index (HI) method was used to assess cumulative risk. The maximum daily dietary exposure to DEHP, DBP, DiBP, and BBP was 5.25, 3.17, 2.59, and 0.58 μg/kg bw/day, respectively, and did not exceed the safety limit values. Cereals and vegetables were the main sources of the estimated daily intake (EDI) of phthalates in the diet. The cumulative risk assessment, based on the European Food Safety Authority tolerable daily intake (TDI) and the US Environmental Protection Agency reference dose (RfD), did not exceed the threshold of 1. DiBP, DBP, and DEHP had higher hazard quotient (HQ) values for cumulative health risk than BBP. In conclusion, a low health risk was posed by the cumulative dietary exposure to phthalates for pregnant women in Beijing. [ABSTRACT FROM AUTHOR]

PAHs are considered carcinogenic chemicals and are concerning as they are important organic pollutants in the environment and human society. The aim of the paper was to determine the levels of polycyclic aromatic hydrocarbons from toasted breads made with different types of flour and using different procedures of toasting. To characterize studied bread, physicochemical analysis (pH, humidity, acidity, elasticity, porosity, sodium chloride, fat, total sugar) and the microbiological examination were done. To estimate the exposure to PAHs, the toxic equivalency quotient (TEQ) was calculated by multiplying each PAH concentration with its toxic equivalency factors (TEFs). The total concentration of the 11 compounds investigated, expressed as the sum of concentrations varies from not detected to 2.9 µg/kg and it was related with the procedure of toasting. The estimated daily intake of total PAHs, based only on consumption of bread range from 0.11 to 10.60 ng/kg b.w day−1. [ABSTRACT FROM AUTHOR]

Risk assessment of cadmium (Cd) for human health play a key role because of toxic effect. Researchers are undergoing constant development for modelling approaches to make a risk assessment. It was carried out a central composite design combining with response surface modeling to optimize and modeling of Cd2+ ions in this study. Also, this study was performed to provide information about possible risk associated with alcoholic beverage consumption. Some independent process parameters including contact time and pH were chosen for optimization. Under optimal parameters, 142.9 mg g−1 was determined as Cd2+ ions removal effectiveness. Significance independent parameters and their interactions were checked using analysis of variance. These results were verified by correlation coefficients (R2 = 0.9967) of the statistical prediction. Estimated daily intake (EDI) and target hazard quotients (THQ) were calculated, to assess health risk. The Cd2+ ions EDI values (µg/day/person) were less than the recommended dietary allowance values and also, its THQ value was less than 1, also. When the obtained results compared with the levels set by regulatory authorities, the studied alcoholic beverages consumption do not pose a toxicological risk. [ABSTRACT FROM AUTHOR]

Methylmercury (MeHg) is one of the most toxic compounds, it bioaccumulates and biomagnifies along the food chain and finally damages human's nervous system. Knowing that the main intake route for MeHg in humans is through fish consumption, intake rates were studied in various countries, but not in Belgium. Based on Hg and MeHg measurements in various fishes, mainly from North Sea catches, in combination with the national food consumption surveys, we could calculate daily Hg and MeHg intake rates for the Belgian population in 1975, 1997 and 2014-2021. These values are then compared with daily intake values reported by other countries and with the acceptable daily intake (ADI) values recommended by international organizations. Daily Hg and MeHg intake rates decreased strongly between 1975 and the 2 later periods: while average intake rates are all below the ADI norms, this is not the case for the 95th percentile rates because they exceed or are very close to the ADI values. Since daily MeHg intake rates correlate well with hair and blood concentrations, these were used as a good proxy of MeHg intoxication and were related to health effects observed in children, adolescents, adults and elderly persons living in Belgium via biomonitoring., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)