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28 results on '"Dai, Mali"'

5. Reduced Contrast Sensitivity Function and Outer Retina thickness in Convalescent Vogt-Koyanagi-Harada Disease

Author

Wang, Yuqin, primary, Li, Yisha, additional, Hu, Xia, additional, Zhou, Fang-Yue, additional, Guo, Xingneng, additional, Yang, Xiaoling, additional, Liu, Ruru, additional, Lin, Dan, additional, Dai, Mali, additional, Wu, Ke, additional, Wu, Jiaqing, additional, Hou, Fang, additional, Lesmes, Luis Andres, additional, and Lu, Zhong-Lin, additional

Published
2024
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6. A Period of Macular Hyperemia and Subclinical Edema Caused by Phacoemulsification Surgery in Noninfectious Uveitis.

Author

Dai, Mali, Feng, Kemi, Guo, Xingneng, Cai, Junyong, Gong, Xianhui, Daliko, Nishimwe Anodine, and Wang, Yuqin

Subjects
*COHERENCE (Optics), *UVEITIS, *ANGIOGRAPHY, *HYPEREMIA, *RETINA, *PHACOEMULSIFICATION
Abstract

To identify the changes in macular microvasculature in uveitic patients following phacoemulsification. A prospective cohort study was conducted by enrolling uveitic patients who underwent phacoemulsification at the Eye Hospital. Macular vessel densities (VD) of superficial and deep capillary plexus (SCP and DCP) and retinal thickness (RT) were quantified by optical coherence tomographic angiography (OCTA). Twenty-one eyes obtained satisfactory OCTA scans at all the follow-up visits. After surgery, an increasing trend in SCP VD was found (p =.037) and reached its maximum (+2.79 ± 4.86%) at post-3 months (M). RT increased synchronously. The increases in SCP VD at post-3 M were significantly correlated with the changes in anterior chamber cells (ACCs) at post-1 M and 2 M (r = 0.450, p =.041; r = 0.477, p =.029, respectively). Inflammation generates a long-term effect on retina demonstrated as an increase in SCP VD and RT which are associated with synchronous ACCs changes after phacoemulsification. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Single-Cell Landscape Reveals the Epithelial Cell-Centric Proinflammatory Immune Microenvironment in Dry Eye Development

Author

Liu, Zihao, primary, Xie, He, additional, Li, Ling, additional, Jiang, Dan, additional, Qian, Yuna, additional, Zhu, Xinhao, additional, Dai, Mali, additional, Li, Yanxiao, additional, Wei, Ruifen, additional, Luo, Zan, additional, Xu, Weihao, additional, Zheng, Qinxiang, additional, Shen, Jianliang, additional, Zhou, Meng, additional, Zeng, Wenwen, additional, and Chen, Wei, additional

Published
2023
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8. Dopamine‐Based High‐Transparent Hydrogel as Bioadhesive for Sutureless Ocular Tissue Repair

Author

Qian, Yuna, primary, Xu, Kejia, additional, Shen, Liangliang, additional, Dai, Mali, additional, Zhao, Zelin, additional, Zheng, Yujing, additional, Wang, Haiou, additional, Xie, Hailin, additional, Wu, Xuan, additional, Xiao, Decheng, additional, Zheng, Qinxiang, additional, Zhang, Jinyi, additional, Song, Yang, additional, Shen, Jianliang, additional, and Chen, Wei, additional

Published
2023
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13. Synergistic Effect of Combined Sub-Tenon Triamcinolone and Intravitreal Anti-VEGF Therapy for Uveitic Macular Edema

Author

Lin,Dan, Hu,Jiajiang, Wu,Ke, Feng,Kemi, Zhao,Xia, Lu,Qingqing, Ren,Mingxue, Cao,Junlin, Liu,Ruru, Dai,Mali, Nan,Kaihui, Wang,Yuqin, Lin,Dan, Hu,Jiajiang, Wu,Ke, Feng,Kemi, Zhao,Xia, Lu,Qingqing, Ren,Mingxue, Cao,Junlin, Liu,Ruru, Dai,Mali, Nan,Kaihui, and Wang,Yuqin

Abstract

Dan Lin,1,&ast; Jiajiang Hu,2,&ast; Ke Wu,1 Kemi Feng,1 Xia Zhao,1 Qingqing Lu,3 Mingxue Ren,1 Junlin Cao,1 Ruru Liu,1 Mali Dai,1 Kaihui Nan,1 Yuqin Wang1 1The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Ophthalmology, Shaoxing Central Hospital, Shaoxing, People’s Republic of China; 3Department of Ophthalmology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Kaihui Nan; Yuqin Wang, The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, People’s Republic of China, Email nankh@163.com; yqwang57@163.comPurpose: To investigate effects of intravitreal anti-VEGF in combination therapy with sub-Tenon triamcinolone acetonide (STA) injection for uveitic macular edema (UME).Design: A single-center, retrospective cohort study.Methods: The medical records were obtained for 65 eyes of 65 patients with UME. Of which, 32 eyes received combined anti-VEGF with STA injection, and 33 eyes received 40 mg of STA injection alone. The primary outcome was the reduction of central macular thickness (CMT) measured with optical coherence tomography (OCT). Resolution rate of clinical UME and changes of best corrected visual acuity (BCVA) over 24 weeks were secondary outcomes.Results: There was a significantly greater reduction of CMT with the combination treatment than with STA alone at 1-week (β = − 157.9, P < 0.001) and 1-month (β = − 53.1, P = 0.019) after injection. The cumulative incidence of macular edema resolution of all eyes was 87.7%, with 90.6% (29/32) in the combined group and 84.8% (28/33) in the STA group, respectively. More incidence of UME resolution was observed in the combined group than the STA group after 1 week (71.9% vs 15.2%, P < 0.001) and 4 weeks (84.4% vs 54.5%, P = 0.009), res

Published
2022

27. Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development

Author

Liu, Zihao, Xie, He, Li, Ling, Jiang, Dan, Qian, Yuna, Zhu, Xinhao, Dai, Mali, Li, Yanxiao, Wei, Ruifen, Luo, Zan, Xu, Weihao, Zheng, Qinxiang, Shen, Jianliang, Zhou, Meng, Zeng, Wenwen, and Chen, Wei

Abstract

Dry eye disease (DED) is a prevalent chronic eye disease characterized by an aberrant inflammatory response in ocular surface mucosa. The immunological alterations underlying DED remain largely unknown. In this study, we employed single-cell transcriptome sequencing of conjunctival tissue from environment-induced DED mice to investigate multicellular ecosystem and functional changes at different DED stages. Our results revealed an epithelial subtype with fibroblastic characteristics and pro-inflammatory effects emerging in the acute phase of DED. We also found that T helper (Th)1, Th17, and regulatory T cells (Treg) were the dominant clusters of differentiation (CD)4+T-cell types involved in regulating immune responses and identified three distinct macrophage subtypes, with the CD72+CD11c+subtype enhancing chronic inflammation. Furthermore, bulk transcriptome analysis of video display terminal-induced DED consistently suggested the presence of the pro-inflammatory epithelial subtype in human conjunctiva. Our findings have uncovered a DED-associated pro-inflammatory microenvironment in the conjunctiva, centered around epithelial cells, involving interactions with macrophages and CD4+T cells, which deepens our understanding of ocular surface mucosal immune responses during DED progression.

Published
2023
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28. Comparison of the Three Sets of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease in Southeast China - A Retrospective Case-Control Study.

Author

Wu J, Pang S, Guo X, Peng W, Lin D, Dai M, Liu R, and Wang Y

Subjects
Humans, Retrospective Studies, Male, Female, Case-Control Studies, China epidemiology, Adult, Middle Aged, Young Adult, Sensitivity and Specificity, Area Under Curve, Uveomeningoencephalitic Syndrome diagnosis, Uveomeningoencephalitic Syndrome epidemiology, ROC Curve
Abstract

Purpose: To compare the utility of the Chinese diagnostic criteria for Vogt-Koyanagi-Harada (VKH) disease (CDCV), the revised diagnostic criteria (RDC) and the classification criteria by SUN (SUN-C)., Methods: Two groups of patients (VKH group and non-VKH group) were assessed in this retrospective case-control study. Sensitivity, specificity and area under receiver operating characteristic curve (AUC) were evaluated among these criteria., Results: 258 patients were included after propensity score matching. The sensitivities were 92.2% in CDCV, 66.7% in RDC, and 54.3% in SUN-C. In different disease stages (early and late), similar sensitivity results were observed. The specificities were 96.1% in CDCV, 97.7% in RDC, and 99.2% in SUN-C. The AUCs were 0.942 in CDCV, 0.822 in RDC and 0.767 in SUN-C., Conclusion: A higher sensitivity value and larger AUC in CDCV were found. CDCV are highly useful in the diagnosis and classification of VKH disease in Chinese patients.

Published
2024
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