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12. Analysis of Surface Defects of High Strength Welding Wire Steel N2M2T Continuous Casting Billet and Process Improvement

Author

Su Yongze, Zhang Xingli, Dai Fangyin, Cui Guibo, Chen Xinyan

Subjects
high strength welding wire steel； casting vibration marks； protective slag； corner cracks； continuous casting billet, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

In response to the surface defects such as concavities， deep vibration marks， cracks， and slag pits on the surface of continuous casting billets during the smelting of N2M2T high-strength welding wire steel in a certain steel plant，combined with theoretical analysis and actual production conditions on site， an analysis was proposed to analyze the surface defects of N2M2T high-strength welding wire steel continuous casting billets from four aspects： the physical and chemical properties of protective slag， mold vibration parameter mode， primary cooling water distribution， and N content in the steel. The analysis results indicate that the surface defects generated by continuous casting billets are mainly related to the physicochemical indicators of the protective slag， mold vibration parameters， and N content in the steel， but not to the primary cooling water distribution. Production practice shows that by increasing the alkalinity of the protective slag from 0. 6 to 1. 19， the C content is reduced from 13. 51% to 8. 21%， and the viscosity is reduced from 0.666 Pa. s to 0.156 Pa. s； The deviation rate of mold vibration parameters has been increased from 0.15 to 0.20， and the vibration frequency formula has been adjusted from 60+50 V to 90+60 V； Control the N content in steel to ＜50 × 10-6， continuous casting process △ N ＜ 7 × 10-6； The surface defects of N2M2T high-strength welding wire steel continuous casting billet have been significantly improved， and the qualification rate of the billet has increased from 85% to over 95%， providing assurance for stable rolling of subsequent steel rolling

Published
2024
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32. High-resolution silkworm pan-genome provides genetic insights into artificial selection and ecological adaptation

Author

Tong, Xiaoling, Han, Min-Jin, Lu, Kunpeng, Tai, Shuaishuai, Liang, Shubo, Liu, Yucheng, Hu, Hai, Shen, Jianghong, Long, Anxing, Zhan, Chengyu, Ding, Xin, Liu, Shuo, Gao, Qiang, Zhang, Bili, Zhou, Linli, Tan, Duan, Yuan, Yajie, Guo, Nangkuo, Li, Yan-Hong, Wu, Zhangyan, Liu, Lulu, Li, Chunlin, Lu, Yaru, Gai, Tingting, Zhang, Yahui, Yang, Renkui, Qian, Heying, Liu, Yanqun, Luo, Jiangwen, Zheng, Lu, Lou, Jinghou, Peng, Yunwu, Zuo, Weidong, Song, Jiangbo, He, Songzhen, Wu, Songyuan, Zou, Yunlong, Zhou, Lei, Cheng, Lan, Tang, Yuxia, Cheng, Guotao, Yuan, Lianwei, He, Weiming, Xu, Jiabao, Fu, Tao, Xiao, Yang, Lei, Ting, Xu, Anying, Yin, Ye, Wang, Jian, Monteiro, Antónia, Westhof, Eric, Lu, Cheng, Tian, Zhixi, Wang, Wen, Xiang, Zhonghuai, and Dai, Fangyin

Published
2022
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39. Disruption of Zfh3 abolishes mulberry‐specific monophagy in silkworm larvae.

Author

Zou, Yunlong, Wu, Wentao, Luo, Tianfu, Tang, Yuxia, Hu, Hai, Ye, Aijun, Xu, Lifeng, Dai, Fangyin, and Tong, Xiaoling

Subjects
TRANSCRIPTION factors, SILKWORMS, PERIPHERAL nervous system, OLFACTORY receptors, TASTE
Abstract

Feeding behavior is critical for insect survival and fitness. Most researchers have explored the molecular basis of feeding behaviors by identifying and elucidating the function of olfactory receptors (ORs) and gustatory receptors (GRs). Other types of genes, such as transcription factors, have rarely been investigated, and little is known about their potential roles. The silkworm (Bombyx mori) is a well‐studied monophagic insect which primarily feeds on mulberry leaves, but the genetic basis of its monophagy is still not understood. In this report, we focused on a transcription factor encoded by the Zfh3 gene, which is highly expressed in the silkworm central and peripheral nervous systems, including brain, antenna, and maxilla. To investigate its function, Zfh3 was abrogated using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) mutagenesis. Since Zfh3 knockout homozygotes are not viable, we studied feeding behavior in heterozygotes, and found that disruption of Zfh3 affects both gustation and olfaction. Mutant larvae lose preference for mulberry leaves, acquire the ability to consume an expanded range of diets, and exhibit improved adaptation to the M0 artificial diet, which contains no mulberry leaves. These results provide the first demonstration that a transcription factor modulates feeding behaviors in an insect. [ABSTRACT FROM AUTHOR]

Published
2024
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40. A PLGA/Silk Fibroin Nanofibre Membrane Loaded with Natural Flavonoid Compounds Extracted from Green Cocoons for Wound Healing.

Author

Chen, Xiang, Liu, Jiaqi, Lu, Yaru, Liu, Huijun, Cheng, Lan, Li, Zhi, and Dai, Fangyin

Subjects
COMPOSITE membranes (Chemistry), BIODEGRADABLE materials, ANIMAL experimentation, SKIN regeneration, GLYCOLIC acid, WOUND healing
Abstract

The use of biodegradable materials combined with natural metabolites in wound dressings has received much attention. Flavonoids (FLs) from green cocoons, as metabolites, have antibacterial, antioxidant, anti-inflammatory, and other pharmacological effects. In this study, composite membranes of FL-loaded polylactic glycolic acid (PLGA)/silk fibroin (SF) were prepared by an electrospinning method. The prepared membranes, including SF, exhibited a good slow-release effect and cytocompatibility. An in vitro evaluation of the FL-loaded PLGA/SF membranes demonstrated good antioxidant, antibacterial, and anti-inflammatory properties. Animal experiments showed that the wound healing rate of PLGA/SF-2.5FL membranes within 15 days was 97.3%, and that of the control group was 72.5%. The PLGA/SF-2.5FL membranes shortened the inflammatory period of a full-layer wound model and promoted skin regeneration and wound healing by downregulating expression of the pro-inflammatory cytokines IL-1β and TNF-α and promoting expression of the growth factors VEGF, TGF-β, and EGF. In summary, the PLGA/SF-2.5FL composite nanofibre membrane with anti-inflammatory properties is an ideal wound dressing to promote acute wound healing. [ABSTRACT FROM AUTHOR]

Published
2024
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49. The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars

Author

Wu, Songyuan, primary, Tong, Xiaoling, additional, Peng, Chenxing, additional, Luo, Jiangwen, additional, Zhang, Chenghao, additional, Lu, Kunpeng, additional, Li, Chunlin, additional, Ding, Xin, additional, Duan, Xiaohui, additional, Lu, Yaru, additional, Hu, Hai, additional, Tan, Duan, additional, and Dai, Fangyin, additional

Published
2024
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