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439 results on '"Dahm‐Kähler, Pernilla"'

5. A federated approach to identify women with early-stage cervical cancer at low risk of lymph node metastases

Author

Wenzel, Hans H.B., Hardie, Anna N., Moncada-Torres, Arturo, Høgdall, Claus K., Bekkers, Ruud L.M., Falconer, Henrik, Jensen, Pernille T., Nijman, Hans W., van der Aa, Maaike A., Martin, Frank, van Gestel, Anna J., Lemmens, Valery E.P.P., Dahm-Kähler, Pernilla, Alfonzo, Emilia, Persson, Jan, Ekdahl, Linnea, Salehi, Sahar, Frøding, Ligita P., Markauskas, Algirdas, Fuglsang, Katrine, and Schnack, Tine H.

Published
2023
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6. Contributors

Author

Aggarwal, Vimla, primary, Barber, T.M., additional, Becker, Christian M., additional, Bhangu, Karanveer, additional, Brännström, Mats, additional, Brown, Carolyn J., additional, Burney, Richard O., additional, Capalbo, Antonio, additional, Chan, Wai-Yee, additional, Chen, Andy Chun Hang, additional, Chen, Chien-Wen, additional, Chen, Ming-Jer, additional, Chen, Zi-Jiang, additional, Chou, Ya-Ching, additional, Choy, Kwong Wai, additional, Clarke, Hugh J., additional, Cordoba, Marcos, additional, Dahm-Kähler, Pernilla, additional, Dai, Mo-Yu, additional, de Paredes, Jessica Garcia, additional, Ding, Guo-Lian, additional, Dong, Zirui, additional, Du, Jin, additional, Eguizabal, C., additional, Fice, Heather E., additional, Franks, S., additional, Gao, Qing-Qin, additional, Giordano, Jessica, additional, Giudice, Linda C., additional, Gosnell, Jordan, additional, Guo, Ting, additional, Haller, Meade, additional, Hardy, Tristan, additional, He, Qilong, additional, Herrera, L., additional, Honaramooz, Ali, additional, Huang, Cheng, additional, Huang, He-Feng, additional, Hussein, Ghada, additional, Jaillard, Sylvie, additional, Jiang, Hai-Ping, additional, Jiang, Zi-Ru, additional, Kasak, Laura, additional, Kawamura, Kazuhiro, additional, Khatibi, Ali, additional, Konwar, Chaini, additional, Laan, Maris, additional, Lai, Guan-Lin, additional, LaMarre, Jonathan, additional, Lamb, Dolores J., additional, Lee, Yin Lau, additional, Lee, Yi-Xuan, additional, Levy, Brynn, additional, Li, Xin-Yuan, additional, Li, Yao, additional, Li, Yu-Fei, additional, Liao, Jinyue, additional, Liu, Ming, additional, Liu, Xiaodong, additional, Liu, Xin-Mei, additional, Lo, Y.M. Dennis, additional, Ma, Xinyi, additional, Ma, Yun-Yi, additional, Martin-Inaraja, M., additional, Missmer, Stacey A., additional, Miu, Kai Kei, additional, Montgomery, Grant, additional, Montserrat, N., additional, Morton, Cynthia C., additional, Navarro-Cobos, Maria Jose, additional, Norman, Robert J., additional, O’Neill, Marisol, additional, Ou, Fanghong, additional, Pang, Yanli, additional, Peñaherrera, Maria S., additional, Poli, Maurizio, additional, Polo, Jose M., additional, Qiao, Jie, additional, Qin, Yingying, additional, Rahmawati, Endah, additional, Rahmioglu, Nilufer, additional, Robaire, Bernard, additional, Robinson, Wendy P., additional, Rogers, Alice P., additional, Rogers, Peter A.W., additional, Romayor, I., additional, Rull, Kristiina, additional, Ruthig, Victor A., additional, Shanahan, Matthew A., additional, Shao, Xuan, additional, Sinclair, Andrew H., additional, Stalker, Leanne, additional, Stanley, Kate, additional, Stosic, Melissa, additional, Strug, Michael, additional, Suen, Hoi-Ching, additional, Tan, Jia Ping, additional, Teixeira, Jose M., additional, Thirumavalavan, Nannan, additional, Tsang, Jason C.H., additional, Tscherner, Allison, additional, Tucker, Elena J., additional, Tzeng, Chii-Ruey, additional, Van den Veyver, Ignatia B., additional, van Riel, Margot, additional, Vermeesch, Joris R., additional, Vossaert, Liesbeth, additional, Wang, Wei, additional, Wang, Yan-Ling, additional, Wang, Zhangting, additional, Wapner, Ronald, additional, Werry, Nicholas, additional, White, Jeffrey T., additional, Wilson, Samantha L., additional, Wu, Jun, additional, Xu, Peng, additional, Yan, Liying, additional, Yan, Zhiqiang, additional, Yeung, William Shu Biu, additional, Yu, Stephanie C.Y., additional, Yuan, Peng, additional, Yuan, Victor, additional, Zhai, Fan, additional, Zhao, Shidou, additional, Zhao, Yue, additional, Zhelyazkova, Boryana, additional, Zhou, Qi, additional, and Zondervan, Krina, additional

Published
2023
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18. The effect of tinzaparin on biomarkers in FIGO stages III-IV ovarian cancer patients undergoing neoadjuvant chemotherapy - the TABANETOC trial : study protocol for a randomized clinical multicenter trial

Author

Karlsson, Anna, Lindahl, Gabriel, Spetz Holm, Anna-Clara, Bergmark, Karin, Dahm Kähler, Pernilla, Fekete, Boglarka, Ottander, Ulrika, Öfverman, Charlotte, Israelsson, Pernilla, Falknäs, Laila, Rosenmüller, Anders, Tiefenthal Thrane, Malena, Halili, Shefqet, Lindahl, Tomas L., Jenmalm, Maria C., Kjølhede, Preben, Karlsson, Anna, Lindahl, Gabriel, Spetz Holm, Anna-Clara, Bergmark, Karin, Dahm Kähler, Pernilla, Fekete, Boglarka, Ottander, Ulrika, Öfverman, Charlotte, Israelsson, Pernilla, Falknäs, Laila, Rosenmüller, Anders, Tiefenthal Thrane, Malena, Halili, Shefqet, Lindahl, Tomas L., Jenmalm, Maria C., and Kjølhede, Preben

Abstract

Background: Tinzaparin, a low-molecular weight heparin (LMWH), has shown anti-neoplastic properties in animal models and in in vitro studies of human cancer cell lines. The reduction of CA-125 levels during neoadjuvant chemotherapy (NACT) in patients with epithelial ovarian cancer (EOC) co-varies with the prognosis; the larger the decrease in CA-125, the better the prognosis. Purpose: This study aims to evaluate the potential anti-neoplastic effects of tinzaparin by investigating changes in serum CA-125 levels in advanced EOC patients who receive NACT. Material and methods: This is an open randomized multicenter pilot trial. Forty patients with EOC selected to receive NACT will be randomized 1:1 to receive daily addition of tinzaparin or no tinzaparin. The processing and treatment of the patients will otherwise follow the recommendations in the Swedish National Guidelines for Ovarian Cancer. Before every cycle of chemotherapy, preoperatively, and 3 weeks after the last cycle of chemotherapy, a panel of biomarkers, including CA-125, will be measured. Patients: Inclusion criteria are women aged 18 years or older, World Health Organization performance status 0–1, histologically confirmed high-grade serous, endometrioid or clear cell EOC, International Federation of Gynecology and Obstetrics (FIGO) stages III-IV. In addition, a CA-125 level of ≥ 250 kIE/L at diagnosis. Exclusion criteria are contraindications to LMWH, ongoing or recent treatment with unfractionated heparin, LMWH, warfarin or non-vitamin K antagonist oral anticoagulants. Interpretation: This study will make an important contribution to the knowledge of the anti-neoplastic effects of tinzaparin in EOC patients and may thus guide the planning of a future study on the impact of tinzaparin on survival in EOC.

Published
2024
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35. #652 Has time to chemotherapy from primary debulking surgery in advanced ovarian cancer an impact on survival? – A population-based nationwide SweGCG study

Author

Dahm-Kähler, Pernilla, primary, Rådestad, Angelique Flöter, additional, Holmberg, Erik, additional, Borgfeldt, Christer, additional, bjurberg, Maria, additional, Sköld, Camilla, additional, Hellman, Kristina, additional, Kjølhede, Preben, additional, Stålberg, Karin, additional, and Åvall-Lundqvist, Elisabeth, additional

Published
2023
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45. First live birth after uterus transplantation in the Middle East

Author

Akouri, Randa, Maalouf, Ghassan, Abboud, Joseph, Nakad, Toufic, Bedran, Farid, Hajj, Pascal, Beaini, Chadia, Cricu, Laura Mihaela, Aftimos, Georges, El Hajj, Chebly, Eid, Ghada, Waked, Abdo, Hallit, Rabih, Gerges, Christian, Rached, Eliane Abi, Matta, Matta, El Khoury, Mirvat, Barakat, Angelique, Kvarnström, Niclas, Dahm-Kähler, Pernilla, and Brännström, Mats

Published
2020
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46. Long-term health-related quality-of-life and psychosocial outcomes after uterus transplantation: a 5-year follow-up of donors and recipients.

Author

Järvholm, Stina, Kättström, Alva, Kvarnström, Niclas, Dahm-Kähler, Pernilla, and Brännström, Mats

Subjects
QUALITY of life, KIDNEY transplantation, MAYER-Rokitansky-Kuster-Hauser syndrome, UTERUS, DYADIC Adjustment Scale, MARITAL satisfaction, MENTAL health
Abstract

STUDY QUESTION What are the outcomes regarding health-related quality-of-life, mood, and marital relationship of recipients and donors 5 years after uterus transplantation (UTx) and uterus donation? SUMMARY ANSWER Both recipients and donors generally demonstrated long-term stability regarding psychosocial outcomes but with negative deviations associated with unsuccessful outcomes. WHAT IS KNOWN ALREADY UTx is the first infertility treatment for women with absolute uterine factor infertility. The procedure can be performed with either a uterus donation from a live donor (LD), typically a close relative, or from a deceased, multi-organ donor. There are many potential stressful events over several years after UTx both for recipients and for LDs and these events may have impacts on quality-of-life and mental well-being. STUDY DESIGN, SIZE, DURATION This, prospective observational cohort study includes the nine recipients and LDs of the first human UTx trial. They were assessed in 2017–2018 by questionnaires 5 years after UTx. PARTICIPANTS/MATERIALS, SETTING, METHODS The nine recipients (ages 32–43 years) and their respective LDs (ages 44–67 years) were either related (n = 8) or friends (n = 1). Eight recipients had congenital uterine absence and one was hysterectomized due to cervical cancer. For two recipients, UTx resulted in early graft failures, while six of the other seven recipients gave birth to a total of eight babies over the following 5 years. Physical and mental component summaries of health-related quality-of-life were measured with the SF-36 questionnaire. Mood was assessed by the Hospital Anxiety and Depression Scale. Relationship with partner was measured with the Dyadic Adjustment Scale. Comparisons were made between the values after 5 years and the values before uterus donation/transplantation. MAIN RESULTS AND THE ROLE OF CHANCE Five years after primary UTx, the majority of recipients scored above the predicted value of the general population on quality-of-life, except for two women, one of whom had a viable graft but no live birth and one recipient who was strained by quality-of-life changes, possibly related to parenthood transitions. Regarding mood, only one value (anxiety) was above the threshold for further clinical assessment. Recipients showed declining satisfaction with their marital relationships, but all reported scores above the 'at risk for divorce' threshold at the time of the final assessment in our study. The LDs were all found to be stable and above the predicted value of the general population regarding mental components of quality-of-life. Three LDs showed declined physical components, possibly related to older age. Only one LD reported a value in mood (anxiety) that would need further assessment. The marital satisfaction of LDs remained stable and unchanged compared to baseline values. Notably, the two recipients with early graft failures, and their related LDs, regained their mental well-being during the first years after graft failure and remained stable after 5 years. LIMITATIONS, REASONS FOR CAUTION The restricted sample size and the single-centre study-design are limitations of this study. Additionally the study was limited to LD UTx, as opposed to deceased donor UTx. WIDER IMPLICATIONS OF THE FINDINGS Our study shows that both LDs and recipients had acceptable or favourable quality-of-life outcomes, including mood assessment, at the 5-year follow-up mark, and that failure to achieve a live birth negatively affected these modalities both for LDs and recipients. Moreover, an important finding was that LDs and recipients are not reacting with depression after hysterectomy, which is common after hysterectomy in the general population. STUDY FUNDING/COMPETING INTEREST(S) Funding was provided by the Jane and Dan Olsson Foundation for Science, Knut and Alice Wallenberg Foundation, Handlanden Hjalmar Svensson Foundation, Swedish Governmental ALF Grant, and Swedish Research Council. There are no conflicts of interest to disclose. TRIAL REGISTRATION NUMBER NCT01844362. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Selecting living donors for uterus transplantation: lessons learned from two transplantations resulting in menstrual functionality and another attempt, aborted after organ retrieval

Author

Brucker, Sara Y., Brännström, Mats, Taran, Florin-Andrei, Nadalin, Silvio, Königsrainer, Alfred, Rall, Katharina, Schöller, Dorit, Henes, Melanie, Bösmüller, Hans, Fend, Falko, Nikolaou, Konstatin, Notohamiprodjo, Mike, Rosenberger, Peter, Grasshoff, Christian, Heim, Eckhard, Krämer, Bernhard, Reisenauer, Christl, Hoopmann, Markus, Kagan, Karl-Oliver, Dahm-Kähler, Pernilla, Kvarnström, Niclas, and Wallwiener, Diethelm

Published
2018
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