791 results on '"Dahlén, Sven-Erik"'
Search Results
2. A single extraction 96-well method for LC-MS/MS quantification of urinary eicosanoids, steroids and drugs
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Sieminska, Julia, Kolmert, Johan, Zurita, Javier, Benkestock, Kurt, Revol-Cavalier, Johanna, Niklinski, Jacek, Reszec, Joanna, Dahlén, Sven-Erik, Ciborowski, Michal, and Wheelock, Craig E.
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- 2024
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3. Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum
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Asamoah, Khezia, Chung, Kian Fan, Zounemat Kermani, Nazanin, Bodinier, Barbara, Dahlen, Sven-Erik, Djukanovic, Ratko, Bhavsar, Pankaj K., Adcock, Ian M., Vuckovic, Dragana, and Chadeau-Hyam, Marc
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- 2024
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4. The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
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Hou, Ruihua, Ye, Gang, Cheng, Xiaojing, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Barbro, Dahlen, Sven-Erik, Fowler, Stephen J., Horváth, Ildikó, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Auffray, Charles, De Meulder, Bertrand, Sousa, Ana R., Adcock, Ian M., Fan Chung, Kian, Sterk, Peter J., Skipp, Paul J., Schofield, James, and Djukanović, Ratko
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- 2023
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5. Stratification of asthma by lipidomic profiling of induced sputum supernatant
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Brandsma, Joost, Schofield, James P.R., Yang, Xian, Strazzeri, Fabio, Barber, Clair, Goss, Victoria M., Koster, Grielof, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Dahlén, Sven-Erik, Fowler, Stephen J., Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Shaw, Dominick E., Chung, Kian Fan, Singer, Florian, Fleming, Louise J., Adcock, Ian M., Pandis, Ioannis, Bansal, Aruna T., Corfield, Julie, Sousa, Ana R., Sterk, Peter J., Sánchez-García, Rubén J., Skipp, Paul J., Postle, Anthony D., and Djukanović, Ratko
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- 2023
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6. Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study
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Badorrek, P., Broeders, M., Boersma, W.G., Chetta, A., Cukier, A., D'Amato, M., Djukanovic, R., Foschino, M.P., Gessner, C., Hanania, N., Martin, R., Milleri, S., Olivenstein, R., Paggiaro, P., Pizzichini, E., Plaza Moral, V., Postma, D.S., Scichilone, N., Schilz, R., Spanevello, A., Stelmach, R., Vroegop, J.S., Usmani, O.S., Zhang, Q., Ahmed, H., Allen, D., Ballereau, S., Batuwitage, M.K., Bedding, A., Behndig, A.F., Berglind, A., Berton, A., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brinkman, P., Bush, A., Campagna, D., Casaulta, C., Chaiboonchoe, A., Davison, T., De Meulder, B., Delin, I., Dennison, P., Dodson, P., El Hadjam, L., Erzen, D., Faulenbach, C., Fichtner, K., Fitch, N., Formaggio, E., Gahlemann, M., Galffy, G., Garissi, D., Garret, T., Guillmant-Farry, E., Henriksson, E., Hoda, U., Hohlfeld, J.M., Hu, X., James, A., Johnson, K., Jullian, N., Kerry, G., Klüglich, M., Knowles, R., Konradsen, J.R., Kretsos, K., Krueger, L., Lantz, A-S., Larminie, C., Latzin, P., Lefaudeux, D., Lemonnier, N., Lowe, L.A., Lutter, R., Manta, A., Mazein, A., McEvoy, L., Menzies-Gow, A., Mores, N., Murray, C.S., Nething, K., Nihlén, U., Niven, R., Nordlund, B., Nsubuga, S., Pellet, J., Pison, C., Praticò, G., Puig Valls, M., Riemann, K., Rocha, J.P., Rossios, C., Santini, G., Sagi, M., Scott, S., Sehgal, N., Selby, A., Söderman, P., Sogbesan, A., Spycher, F., Stephan, S., Stokholm, J., Sunther, M., Szentkereszty, M., Tamasi, L., Tariq, K., Valente, S, Van Aalderen, W.M., Van Drunen, C.M., Van Eyll, J., Vyas, A., Yu, W., Zetterguist, W., Zolkipli, Z., Zwinderman, A.H., Agusti, A., Wedzicha, J.A., Donaldson, G.C., Faner, R., Breyer-Kohansal, R., Maitland-van der Zee, A.H., Melén, E., Allinson, J.P., Vanfleteren, L.E.G.W., Vestbo, J., Adcock, I.M., Lahousse, L., Van den Berge, M., Alter, P., Barbe, F., Brightling, C.E., Breyer, M.K., Burghuber, O.C., Casas, M., Chung, K.F., Cosío, B.G., Crispi, F., De Batlle, J., Fitting, J.W., Garcia, J., Hallberg, J., Hartl, S., Jarvis, D., Mathioudakis, A., Nicod, L., Papi, A., Ritchie, A., Sigsgaard, T., Sterk, P.J., Ullman, A., Vellvé, K., Vogelmeier, C., Wheelock, A.M., Wheelock, C.E., Kole, Tessa M, Vanden Berghe, Elise, Kraft, Monica, Vonk, Judith M, Nawijn, Martijn C, Siddiqui, Salman, Sun, Kai, Fabbri, Leonardo M, Rabe, Klaus F, Chung, Kian Fan, Nicolini, Gabriele, Papi, Alberto, Brightling, Chris, Singh, Dave, van der Molen, Thys, Dahlén, Sven-Erik, Agusti, Alvar, Faner, Rosa, Wedzicha, Jadwiga A, Donaldson, Gavin C, Adcock, Ian M, Lahousse, Lies, Kerstjens, Huib A M, and van den Berge, Maarten
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- 2023
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7. Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor
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Säfholm, Jesper, Abma, Willem, Bankova, Lora G., Boyce, Joshua A., Al-Ameri, Mamdoh, Orre, Ann-Charlotte, Wheelock, Craig E., Dahlén, Sven-Erik, and Adner, Mikael
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- 2022
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8. Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers.
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Brinkman, Paul, Wilde, Michael, Ahmed, Waqar, Wang, Ran, van der Schee, Marc, Abuhelal, Shahd, Schaber, Chad, Cunoosamy, Danen, Clarke, Graham W., Maitland-van der Zee, Anke-Hilse, Dahlén, Sven-Erik, Siddiqui, Salman, and Fowler, Stephen J.
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BIOMARKERS ,VOLATILE organic compounds ,INDIVIDUALIZED medicine ,TECHNOLOGY assessment ,LUNG diseases - Abstract
The exhaled breath represents an ideal matrix for noninvasive biomarker discovery, and exhaled metabolomics have the potential to be clinically useful in the era of precision medicine. In this concise translational review, we specifically address volatile organic compounds in the breath, with a view toward fulfilling the promise of these as actionable biomarkers, in particular, for lung diseases. We review the literature paying attention to seminal work linked to key milestones in breath research; discuss potential applications for breath biomarkers across disease areas and healthcare systems, including the perspectives of industry; and outline critical aspects of study design that will need to be considered for any pivotal research going forward if breath analysis is to provide robust validated biomarkers that meet the requirements for future clinical implementation. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing
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Mazzurana, Luca, Czarnewski, Paulo, Jonsson, Viktor, Wigge, Leif, Ringnér, Markus, Williams, Teresa C., Ravindran, Avinash, Björklund, Åsa K., Säfholm, Jesper, Nilsson, Gunnar, Dahlén, Sven-Erik, Orre, Ann-Charlotte, Al-Ameri, Mamdoh, Höög, Charlotte, Hedin, Charlotte, Szczegielniak, Sylwester, Almer, Sven, and Mjösberg, Jenny
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- 2021
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10. IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways
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Manson, Martijn L., Säfholm, Jesper, James, Anna, Johnsson, Anna-Karin, Bergman, Per, Al-Ameri, Mamdoh, Orre, Ann-Charlotte, Kärrman-Mårdh, Carina, Dahlén, Sven-Erik, and Adner, Mikael
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- 2020
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11. Clinical relevance of type 2 inflammation as a driver of multi-organ disease: A Delphi consensus initiative
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Björnsdóttir, Unnur Steina, primary, Deleuran, Mette, additional, Janson, Christer, additional, Makela, Mika, additional, Porsbjerg, Celeste, additional, Toppila-Salmi, Sanna, additional, Aanæs, Kasper, additional, Agner, Tove, additional, Ahlbeck, Lars, additional, Altraja, Alan, additional, Bjermer, Leif, additional, Bradley, Maria, additional, Cardell, Lars Olaf, additional, Dahlén, Sven-Erik, additional, Eyerich, Kilian, additional, Hedlin, Gunilla, additional, Huldt-Nystrøm, Theis, additional, Jørstad, Stein Øyvind, additional, Kankaanranta, Hannu, additional, Karjalainen, Jussi, additional, Korhonen, Laura, additional, Lehtimäki, Lauri, additional, Mandelin, Johanna, additional, Remitz, Anita, additional, Sonesson, Andreas, additional, Steinsvåg, Sverre, additional, Thomsen, Simon Francis, additional, Ulrik, Charlotte, additional, Vestergaard, Christian, additional, and Thyssen, Jacob, additional
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- 2024
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12. IL-17–high asthma with features of a psoriasis immunophenotype
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Adcock, I.M., Ahmed, H., Auffray, C., Bakke, P., Bansal, A.T., Baribaud, F., Bates, S., Bel, E.H., Bigler, J., Bisgaard, H., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Brinkman, P., Bucchioni, E., Burg, D., Bush, A., Caruso, M., Chaiboonchoe, A., Chanez, P., Chung, K.F., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., De Meulder, B., Djukanovic, R., Erpenbeck, V.J., Erzen, D., Fichtner, K., Fitch, N., Fleming, L.J., Formaggio, E., Fowler, S.J., Frey, U., Gahlemann, M., Geiser, T., Guo, Y., Hashimoto, S., Haughney, J., Hedlin, G., Hekking, P.W., Higenbottam, T., Hohlfeld, J.M., Holweg, C., Horváth, I., Howarth, P., James, A.J., Knowles, R., Knox, A.J., Krug, N., Lefaudeux, D., Loza, M.J., Lutter, R., Manta, A., Masefield, S., Mazein, A., Meiser, A., Middelveld, R.J.M., Miralpeix, M., Montuschi, P., Mores, N., Murray, C.S., Musial, J., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powell, P., Praticò, G., Rao, M. Puig N., Riley, J., Roberts, A., Roberts, G., Rowe, A., Sandström, T., Seibold, W., Selby, A., Shaw, D.E., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Aalderen, W.M., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J., Aliprantis, Antonios, Allen, David, Alving, Kjell, Badorrek, P., Balgoma, David, Ballereau, S., Barber, Clair, Batuwitage, Manohara Kanangana, Bautmans, A., Bedding, A., Behndig, A.F., Beleta, Jorge, Berglind, A., Berton, A., Bochenek, Grazyna, Braun, Armin, Campagna, D., Carayannopoulos, Leon, Casaulta, C., Chaleckis, Romanas, Dahlén, B., Davison, imothy, De Alba, Jorge, De Lepeleire, Inge, Dekker, Tamara, Delin, Ingrid, Dennison, P., Dijkhuis, Annemiek, Dodson, Paul, Draper, Aleksandra, Dyson, K., Edwards, Jessica, El Hadjam, L., Emma, Rosalia, Ericsson, Magnus, Faulenbach, C., Flood, Breda, Galffy, G., Gallart, Hector, Garissi, D., Gent, J., Gerhardsson de Verdier, M., Gibeon, D., Gomez, Cristina, Gove, Kerry, Gozzard, Neil, Guillmant-Farry, E., Henriksson, E., Hewitt, Lorraine, Hoda, U., Hu, Richard, Hu, Sile, Hu, X., Jeyasingham, E., Johnson, K., Jullian, N., Kamphuis, Juliette, Kennington, Erika J., Kerry, Dyson, Kerry, G., Klüglich, M., Knobel, Hugo, Kolmert, Johan, Konradsen, J.R., Kots, Maxim, Kretsos, Kosmas, Krueger, L., Kuo, Scott, Kupczyk, Maciej, Lambrecht, Bart, Lantz, A.-S., Larminie, Christopher, Larsson, L.X., Latzin, P., Lazarinis, N., Lemonnier, N., Lone-Latif, Saeeda, Lowe, L.A., Manta, Alexander, Marouzet, Lisa, Martin, Jane, Mathon, Caroline, McEvoy, L., Meah, Sally, Menzies-Gow, A., Metcalf, Leanne, Mikus, Maria, Monk, Philip, Naz, Shama, Nething, K., Nicholas, Ben, Nihlén, U., Nilsson, Peter, Niven, R., Nordlund, B., Nsubuga, S., Pacino, Antonio, Palkonen, Susanna, Pellet, J., Pennazza, Giorgio, Petrén, Anne, Pink, Sandy, Pison, C., Postle, Anthony, Rahman-Amin, Malayka, Ravanetti, Lara, Ray, Emma, Reinke, Stacey, Reynolds, Leanne, Riemann, K., Robberechts, Martine, Rocha, J.P., Rossios, C., Russell, Kirsty, Rutgers, Michael, Santini, G., Santoninco, Marco, Saqi, M., Schoelch, Corinna, Schofield, James P.R., Scott, S., Sehgal, N., Sjödin, Marcus, Smids, Barbara, Smith, Caroline, Smith, Jessica, Smith, Katherine M., Söderman, P., Sogbessan, A., Spycher, F., Staykova, Doroteya, Stephan, S., Stokholm, J., Strandberg, K., Sunther, M., Szentkereszty, M., Tamasi, L., Tariq, K., Thörngren, John-Olof, Thorsen, Jonathan, Valente, S., van de Pol, Marianne, van Drunen, C.M., Van Eyll, Jonathan, Versnel, Jenny, Vink, Anton, von Garnier, C., Vyas, A., Wald, Frans, Walker, Samantha, Ward, Jonathan, Wetzel, Kristiane, Wiegman, Coen, Williams, Siân, Yang, Xian, Yeyasingham, Elizabeth, Amgen, W. Yu, Zetterquist, W., Zolkipli, Z., Zwinderman, A.H., Östling, Jörgen, van Geest, Marleen, Jevnikar, Zala, Wilson, Susan, Lutter, Rene, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Sven-Erik, Fowler, Stephen J., Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Sun, Kai, Pandis, Ioannis, Auffray, Charles, Sousa, Ana R., Guo, Yike, Adcock, Ian M., Howarth, Peter, Chung, Kian Fan, Bigler, Jeanette, Sterk, Peter J., Skipp, Paul J., Djukanović, Ratko, and Vaarala, Outi
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- 2019
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13. Mannitol triggers mast cell–dependent contractions of human small bronchi and prostacyclin bronchoprotection
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Säfholm, Jesper, Manson, Martijn L., Bood, Johan, Al-Ameri, Mamdoh, Orre, Ann-Charlotte, Raud, Johan, Dahlén, Sven-Erik, and Adner, Mikael
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- 2019
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14. Stratification of asthma phenotypes by airway proteomic signatures
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Ahmed, H., Allen, D., Badorrek, P., Ballereau, S., Baribaud, F., Bedding, A., Behndig, A.F., Berglind, A., Berton, A., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brinkman, P., Bush, A., Campagna, D., Casaulta, C., Chaiboonchoe, A., Davison, T., De Meulder, B., Delin, I., Dennison, P., Dodson, P., El Hadjam, L., Erzen, D., Faulenbach, C., Fichtner, K., Fitch, N., Formaggio, E., Gahlemann, M., Galffy, G., Garissi, D., Garret, T., Gent, J., Guillmant-Farry, E., Henriksson, E., Hoda, U., Hohlfeld, J.M., Hu, X., James, A., Johnson, K., Jullian, N., Kerry, G., Klüglich, M., Knowles, R., Konradsen, J.R., Kretsos, K., Krueger, L., Lantz, A.-S., Larminie, C., Latzin, P., Lefaudeux, D., Lemonnier, N., Lowe, L.A., Lutter, R., Manta, A., Mazein, A., McEvoy, L., Menzies-Gow, A., Mores, N., Murray, C.S., Nething, K., Nihlén, U., Niven, R., Nordlund, B., Nsubuga, S., Pellet, J., Pison, C., Praticò, G., Valls, M. Puig, Riemann, K., Rocha, J.P., Rossios, C., Santini, G., Saqi, M., Scott, S., Sehgal, N., Selby, A., Söderman, P., Sogbesan, A., Spycher, F., Stephan, S., Stokholm, J., Sunther, M., Szentkereszty, M., Tamasi, L., Tariq, K., Valente, S., van Aalderen, W.M., van Drunen, C.M., Van Eyll, J., Vyas, A., Yu, W., Zetterquist, W., Zolkipli, Z., Zwinderman, A.H., Schofield, James P.R., Burg, Dominic, Nicholas, Ben, Strazzeri, Fabio, Brandsma, Joost, Staykova, Doroteya, Folisi, Caterina, Bansal, Aruna T., Xian, Yang, Guo, Yike, Rowe, Anthony, Corfield, Julie, Wilson, Susan, Ward, Jonathan, Lutter, Rene, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Sven-Erik, Fowler, Stephen J., Horváth, Ildikó, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Sun, Kai, Pandis, Ioannis, Riley, John, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Sousa, Ana R., Adcock, Ian M., Chung, Kian Fan, Sterk, Peter J., Skipp, Paul J., and Djukanović, Ratko
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- 2019
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15. Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation
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Maric, Jovana, Ravindran, Avinash, Mazzurana, Luca, Van Acker, Aline, Rao, Anna, Kokkinou, Efthymia, Ekoff, Maria, Thomas, Dominique, Fauland, Alexander, Nilsson, Gunnar, Wheelock, Craig E., Dahlén, Sven-Erik, Ferreirós, Nerea, Geisslinger, Gerd, Friberg, Danielle, Heinemann, Akos, Konya, Viktoria, and Mjösberg, Jenny
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- 2019
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16. Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma
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Brinkman, Paul, Wagener, Ariane H., Hekking, Pieter-Paul, Bansal, Aruna T., Maitland-van der Zee, Anke-Hilse, Wang, Yuanyue, Weda, Hans, Knobel, Hugo H., Vink, Teunis J., Rattray, Nicholas J., D'Amico, Arnaldo, Pennazza, Giorgio, Santonico, Marco, Lefaudeux, Diane, De Meulder, Bertrand, Auffray, Charles, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Chung, Kian F., Corfield, Julie, Dahlén, Sven-Erik, Djukanovic, Ratko, Geiser, Thomas, Horvath, Ildiko, Krug, Nobert, Musial, Jacek, Sun, Kai, Riley, John H., Shaw, Dominic E., Sandström, Thomas, Sousa, Ana R., Montuschi, Paolo, Fowler, Stephen J., and Sterk, Peter J.
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- 2019
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17. Patient-centred composite index for assessment of response to biological therapy for adult severe asthma.
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Khaleva, Ekateirina, primary, Brightling, Chris, additional, Djukanovic, Ratko, additional, Dahlén, Sven-Erik, additional, Coleman, Courtney, additional, Henderson, Markaya, additional, and Roberts, Graham, additional
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- 2023
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18. Data-driven model links BMIz to gene expression in pediatric asthma
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Dandenault, Vincent, primary, Hachem, Nehme, additional, Adcock, Ian M, additional, Andersson, Lars I., additional, Auffray, Charles, additional, Chung, Fan K, additional, Dahlén, Sven-Erik, additional, De Meulder, Bertrand, additional, Djukanovic, Ratko, additional, Howarth, Peter, additional, Knowles, Richard G, additional, Krug, Norbert, additional, Roberts, Amanda, additional, Sousa, Ana R, additional, Sterk, Peter J., additional, Supple, David, additional, Rao, Navin, additional, Roberts, Graham, additional, Uddin, Mohib, additional, Wagers, Scott, additional, Maitland-Van Der Zee, Anke-Hilse, additional, and Longo, Cristina, additional
- Published
- 2023
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19. Late Breaking Abstract - Dynamics of the blood innate lymphoid cell compartment in patients with severe asthma undergoing type 2 biologics treatment: Initial findings in the BIOCROSS study
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Wirth, Lorenz, primary, Yasinska, Valentyna, additional, Tibbitt, Christopher Andrew, additional, Weigel, Whitney, additional, Hochdörfer, Thomas, additional, Andersson, Lars I., additional, Sparreman-Mikus, Maria, additional, Dahlén, Barbro, additional, Dahlén, Sven-Erik, additional, and Mjösberg, Jenny, additional
- Published
- 2023
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20. Epithelial alarmins enhance mast cell-dependent contractions of isolated human small bronchi
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Belikova, Maria, primary, Säfholm, Jesper, additional, Al-Ameri, Mamdoh, additional, Orre, Ann-Charlotte, additional, Dahlén, Sven-Erik, additional, and Adner, Mikael, additional
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- 2023
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21. Urinary eicosanoids - novel biomarkers in T2-low severe asthma
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Eastwood, Matthew, primary, Busby, John, additional, Kolmert, Johan, additional, Wheelock, Craig, additional, Dahlén, Sven-Erik, additional, Mcdowell, Pamela-Jane, additional, Jackson, David, additional, Djukanovic, Ratko, additional, Matthews, John, additional, Arron, Joseph, additional, Bradding, Peter, additional, Brightling, Chris, additional, Chaudhuri, Rekha, additional, Choy, David, additional, Cowan, Douglas, additional, Fowler, Stephen, additional, Hanratty, Catherine, additional, Hardman, Timothy, additional, Harrison, Timothy, additional, Holweg, Cecile, additional, Howarth, Peter, additional, Lordan, James, additional, Mansur, Adel, additional, Menzies-Gow, Andrew, additional, Pavord, Ian, additional, Robinson, Douglas, additional, Walker, Samantha, additional, Woodcock, Ashley, additional, and Heaney, Liam, additional
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- 2023
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22. Defining the prostanoid component in mast cell-dependent constriction of isolated human small airways
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Säfholm, Jesper, primary, Dahlén, Sven-Erik, additional, and Adner, Mikael, additional
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- 2023
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23. Prediction of severe asthma clinical phenotypes using molecular profiles of urine eicosanoids
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Kolmert, Johan, primary, Sparreman-Mikus, Maria, additional, De Meulder, Bertrand, additional, Andersson, Lars I, additional, Adcook, Ian, additional, Djukanovic, Ratko, additional, Dahlén, Sven-Erik, additional, and Wheeelock, Craig E., additional
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- 2023
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24. Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
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Yasinska, Valentyna, primary, Gómez, Cristina, additional, Kolmert, Johan, additional, Ericsson, Magnus, additional, Pohanka, Anton, additional, James, Anna, additional, Andersson, Lars I., additional, Sparreman-Mikus, Maria, additional, Sousa, Ana R., additional, Riley, John H., additional, Bates, Stewart, additional, Bakke, Per S., additional, Zounemat Kermani, Nazanin, additional, Caruso, Massimo, additional, Chanez, Pascal, additional, Fowler, Stephen J., additional, Geiser, Thomas, additional, Howarth, Peter H., additional, Horváth, Ildikó, additional, Krug, Norbert, additional, Montuschi, Paolo, additional, Sanak, Marek, additional, Behndig, Annelie, additional, Shaw, Dominick E., additional, Knowles, Richard G., additional, Dahlén, Barbro, additional, Maitland-van der Zee, Anke-Hilse, additional, Sterk, Peter J., additional, Djukanovic, Ratko, additional, Adcock, Ian M., additional, Fan Chung, Kian, additional, Wheelock, Craig E., additional, Dahlén, Sven-Erik, additional, and Wikström Jonsson, Eva, additional
- Published
- 2023
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25. Leukotriene receptors in GtoPdb v.2023.1
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Bäck, Magnus, primary, Brink, Charles, primary, Chiang, Nan, primary, Dahlén, Sven-Erik, primary, Dent, Gordon, primary, Drazen, Jeffrey, primary, Evans, Jilly F., primary, Hay, Douglas W. P., primary, Nakamura, Motonao, primary, Powell, William, primary, Rokach, Joshua, primary, Rovati, G. Enrico, primary, Serhan, Charles N., primary, Shimizu, Takao, primary, Uddin, Mohib, primary, and Yokomizo, Takehiko, primary
- Published
- 2023
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26. Analysis of human lung mast cells by single cell RNA sequencing
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Rönnberg, Elin, primary, Ravindran, Avinash, additional, Mazzurana, Luca, additional, Gong, Yitao, additional, Säfholm, Jesper, additional, Lorent, Julie, additional, Dethlefsen, Olga, additional, Orre, Ann-Charlotte, additional, Al-Ameri, Mamdoh, additional, Adner, Mikael, additional, Dahlén, Sven-Erik, additional, Dahlin, Joakim S., additional, Mjösberg, Jenny, additional, and Nilsson, Gunnar, additional
- Published
- 2023
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27. Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
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Yasinska, Valentyna, Gómez, Cristina, Kolmert, Johan, Ericsson, Magnus, Pohanka, Anton, James, Anna, Andersson, Lars I., Sparreman-Mikus, Maria, Sousa, Ana R., Riley, John H., Bates, Stewart, Bakke, Per S., Kermani, Nazanin Zounemat, Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter H., Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Behndig, Annelie F., Shaw, Dominick E., Knowles, Richard G., Dahlén, Barbro, van der Zee, Anke-Hilse Maitland, Sterk, Peter J., Djukanovic, Ratko, Adcock, Ian M., Chung, Kian Fan, Wheelock, Craig E., Dahlén, Sven-Erik, Jonsson, Eva Wikström, Yasinska, Valentyna, Gómez, Cristina, Kolmert, Johan, Ericsson, Magnus, Pohanka, Anton, James, Anna, Andersson, Lars I., Sparreman-Mikus, Maria, Sousa, Ana R., Riley, John H., Bates, Stewart, Bakke, Per S., Kermani, Nazanin Zounemat, Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter H., Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Behndig, Annelie F., Shaw, Dominick E., Knowles, Richard G., Dahlén, Barbro, van der Zee, Anke-Hilse Maitland, Sterk, Peter J., Djukanovic, Ratko, Adcock, Ian M., Chung, Kian Fan, Wheelock, Craig E., Dahlén, Sven-Erik, and Jonsson, Eva Wikström
- Abstract
Rationale: Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure. Methods: Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study. Measurements and main results: The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12–18 months. Conclusion: The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma.
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- 2023
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28. Analysis of human lung mast cells by single cell RNA sequencing
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Rönnberg, Elin, Ravindran, Avinash, Mazzurana, Luca, Gong, Yitao, Säfholm, Jesper, Lorent, Julie, Dethlefsen, Olga, Orre, Ann-Charlotte, Al-Ameri, Mamdoh, Adner, Mikael, Dahlén, Sven-Erik, Dahlin, Joakim S., Mjösberg, Jenny, Nilsson, Gunnar, Rönnberg, Elin, Ravindran, Avinash, Mazzurana, Luca, Gong, Yitao, Säfholm, Jesper, Lorent, Julie, Dethlefsen, Olga, Orre, Ann-Charlotte, Al-Ameri, Mamdoh, Adner, Mikael, Dahlén, Sven-Erik, Dahlin, Joakim S., Mjösberg, Jenny, and Nilsson, Gunnar
- Abstract
Mast cells are tissue-resident cells playing major roles in homeostasis and disease conditions. Lung mast cells are particularly important in airway inflammatory diseases such as asthma. Human mast cells are classically divided into the subsets MCT and MCTC, where MCT express the mast cell protease tryptase and MCTC in addition express chymase, carboxypeptidase A3 (CPA3) and cathepsin G. Apart from the disctintion of the MCT and MCTC subsets, little is known about the heterogeniety of human lung mast cells and a deep analysis of their heterogeniety has previously not been performed. We therefore performed single cell RNA sequencing on sorted human lung mast cells using SmartSeq2. The mast cells showed high expression of classical mast cell markers. The expression of several individual genes varied considerably among the cells, however, no subpopulations were detected by unbiased clustering. Variable genes included the protease-encoding transcripts CMA1 (chymase) and CTSG (cathepsin G). Human lung mast cells are predominantly of the MCT subset and consistent with this, the expression of CMA1 was only detectable in a small proportion of the cells, and correlated moderately to CTSG. However, in contrast to established data for the protein, CPA3 mRNA was high in all cells and the correlation of CPA3 to CMA1 was weak.
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- 2023
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29. Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
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Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J., Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H., Melén, Erik, Murray, Clare S., Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C., Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W., Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A., Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G., Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke-Hilse, Mahler, Vera, Schoos, Ann Marie M., Nagakumar, Prasad, Negus, Jenny, Nielsen, Hanna, Pijnenburg, Mariëlle, Ramiconi, Valeria, Romagosa Vilarnau, Sofia, Principe, Stefania, Rutjes, Niels W. P., Saglani, Sejal, Seddon, Paul C, Singer, Florian, Staudinger, Heribert, Turner, Steve, Vijverberg, Susanne J, Winders, Tonya, Yasinska, Valentyna, Roberts, Graham, Sverrild, Asger, Lapperre, Therese, Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J., Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H., Melén, Erik, Murray, Clare S., Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C., Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W., Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A., Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G., Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke-Hilse, Mahler, Vera, Schoos, Ann Marie M., Nagakumar, Prasad, Negus, Jenny, Nielsen, Hanna, Pijnenburg, Mariëlle, Ramiconi, Valeria, Romagosa Vilarnau, Sofia, Principe, Stefania, Rutjes, Niels W. P., Saglani, Sejal, Seddon, Paul C, Singer, Florian, Staudinger, Heribert, Turner, Steve, Vijverberg, Susanne J, Winders, Tonya, Yasinska, Valentyna, Roberts, Graham, Sverrild, Asger, and Lapperre, Therese
- Abstract
Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies. Methods COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult and paediatric clinicians, pharmaceutical representatives, and health regulators from across Europe. Evidence included a systematic review of development, validity and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria. Results Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z-scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire and Asthma Control Test or Childhood Asthma Control Test, while the adult COM set includes the Severe Asthma Questionnaire and Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately). Conclusions This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma., Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies. Methods COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult and paediatric clinicians, pharmaceutical representatives, and health regulators from across Europe. Evidence included a systematic review of development, validity and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria. Results Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z-scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire and Asthma Control Test or Childhood Asthma Control Test, while the adult COM set includes the Severe Asthma Questionnaire and Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately). Conclusions This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.
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- 2023
30. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis
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Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter, Bush, Andrew, Caballero-Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai-Hakon, Carr, Warner, Casale, Thomas B., Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi, Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander, Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven-Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh-Xuan, Anh-Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, El-Gamal, Yehia, Emuzyte, Regina, Fink-Wagner, Antje, Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, Jose E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Haahtela, Tari, Heinrich, Joachim, Hellquist-Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan-Carlos, Jares, Edgardo J., Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki-Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa, Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vitezlav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jing, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale-Manuel, Sandra, Melén, Erik, Melo-Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla-Santana, Anna, Morais-Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier-Luigi, Pali-Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor, Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka-Ramirez, Maria-Susana, Robalo-Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado-Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sanchez-Borges, Mario, Sastre-Dominguez, Joaquim, Schmid-Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul, Juan-Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Rafael, Strandberg, Timo, Sunyer, Jordi, Thijs, Carel, Todo-Bom, Ana-Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, Denis, Wright, John, Yawn, Barbara P., Yiallouros, Panayiotis, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl-Christian, Bosnic-Anticevich, Sinthia, Brozek, Jan, Calderon, Moises, Canonica, G. Walter, Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Alvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao, Gonzalez-Diaz, Sandra N., Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas-Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, Eli O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, and Zuberbier, Torsten
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- 2016
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31. Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung
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Jandl, Katharina, Stacher, Elvira, Bálint, Zoltán, Sturm, Eva Maria, Maric, Jovana, Peinhaupt, Miriam, Luschnig, Petra, Aringer, Ida, Fauland, Alexander, Konya, Viktoria, Dahlen, Sven-Erik, Wheelock, Craig E., Kratky, Dagmar, Olschewski, Andrea, Marsche, Gunther, Schuligoi, Rufina, and Heinemann, Akos
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- 2016
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32. Food allergy-related concerns during the transition to self-management
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Protudjer, Jennifer Lisa Penner, Middelveld, Roelinde, Dahlén, Sven-Erik, Ahlstedt, Staffan, and FoodHE Investigators
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- 2019
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33. Combined exposure to the alarmins TSLP, IL‐33 and IL‐25 enhances mast cell‐dependent contractions of human bronchi.
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Belikova, Maria, Säfholm, Jesper, Al‐Ameri, Mamdoh, Orre, Ann‐Charlotte, Dahlén, Sven‐Erik, and Adner, Mikael
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THYMIC stromal lymphopoietin ,INTERLEUKIN-33 ,BRONCHI ,SMOOTH muscle contraction ,EXERCISE-induced asthma - Abstract
Combined exposure to the alarmins TSLP, IL-33 and IL-25 enhances mast cell-dependent contractions of human bronchi Keywords: airway hyperresponsiveness; anti-IgE; asthma; histamine; IL-33; prostaglandin D2; TSLP EN airway hyperresponsiveness anti-IgE asthma histamine IL-33 prostaglandin D2 TSLP 1062 1066 5 10/09/23 20231001 NES 231001 Key Messages Combined pretreatment with TSLP, IL-33 and IL-25 (epithelial alarmins) enhanced IgE-triggered contraction in isolated human bronchi. The release of histamine in response to IgE-mediated stimulation increased only in the alarmin mix pretreated group, indicating that, as shown for PGD SB 2, sb the alarmin mix enhanced the IgE-triggered release of histamine, presumably by increasing mast cell reactivity. Airway hyperresponsiveness, asthma, histamine, IL-33, anti-IgE, TSLP, prostaglandin D2. [Extracted from the article]
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- 2023
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34. Definitions of non-response and response to biological therapy for severe asthma: a systematic review
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Khaleva, Ekaterina, primary, Rattu, Anna, additional, Brightling, Chris, additional, Bush, Andrew, additional, Bourdin, Arnaud, additional, Bossios, Apostolos, additional, Chung, Kian Fan, additional, Chaudhuri, Rekha, additional, Coleman, Courtney, additional, Djukanovic, Ratko, additional, Dahlén, Sven-Erik, additional, Exley, Andrew, additional, Fleming, Louise, additional, Fowler, Stephen J., additional, Gupta, Atul, additional, Hamelmann, Eckard, additional, Koppelman, Gerard H., additional, Melén, Erik, additional, Mahler, Vera, additional, Seddon, Paul, additional, Singer, Florian, additional, Porsbjerg, Celeste, additional, Ramiconi, Valeria, additional, Rusconi, Franca, additional, Yasinska, Valentyna, additional, and Roberts, Graham, additional
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- 2023
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35. Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study
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Kole, Tessa M, primary, Vanden Berghe, Elise, additional, Kraft, Monica, additional, Vonk, Judith M, additional, Nawijn, Martijn C, additional, Siddiqui, Salman, additional, Sun, Kai, additional, Fabbri, Leonardo M, additional, Rabe, Klaus F, additional, Chung, Kian Fan, additional, Nicolini, Gabriele, additional, Papi, Alberto, additional, Brightling, Chris, additional, Singh, Dave, additional, van der Molen, Thys, additional, Dahlén, Sven-Erik, additional, Agusti, Alvar, additional, Faner, Rosa, additional, Wedzicha, Jadwiga A, additional, Donaldson, Gavin C, additional, Adcock, Ian M, additional, Lahousse, Lies, additional, Kerstjens, Huib A M, additional, van den Berge, Maarten, additional, Badorrek, P., additional, Broeders, M., additional, Boersma, W.G., additional, Chetta, A., additional, Cukier, A., additional, D'Amato, M., additional, Djukanovic, R., additional, Foschino, M.P., additional, Gessner, C., additional, Hanania, N., additional, Martin, R., additional, Milleri, S., additional, Olivenstein, R., additional, Paggiaro, P., additional, Pizzichini, E., additional, Plaza Moral, V., additional, Postma, D.S., additional, Scichilone, N., additional, Schilz, R., additional, Spanevello, A., additional, Stelmach, R., additional, Vroegop, J.S., additional, Usmani, O.S., additional, Zhang, Q., additional, Ahmed, H., additional, Allen, D., additional, Ballereau, S., additional, Batuwitage, M.K., additional, Bedding, A., additional, Behndig, A.F., additional, Berglind, A., additional, Berton, A., additional, Bigler, J., additional, Boedigheimer, M.J., additional, Bønnelykke, K., additional, Brinkman, P., additional, Bush, A., additional, Campagna, D., additional, Casaulta, C., additional, Chaiboonchoe, A., additional, Davison, T., additional, De Meulder, B., additional, Delin, I., additional, Dennison, P., additional, Dodson, P., additional, El Hadjam, L., additional, Erzen, D., additional, Faulenbach, C., additional, Fichtner, K., additional, Fitch, N., additional, Formaggio, E., additional, Gahlemann, M., additional, Galffy, G., additional, Garissi, D., additional, Garret, T., additional, Guillmant-Farry, E., additional, Henriksson, E., additional, Hoda, U., additional, Hohlfeld, J.M., additional, Hu, X., additional, James, A., additional, Johnson, K., additional, Jullian, N., additional, Kerry, G., additional, Klüglich, M., additional, Knowles, R., additional, Konradsen, J.R., additional, Kretsos, K., additional, Krueger, L., additional, Lantz, A-S., additional, Larminie, C., additional, Latzin, P., additional, Lefaudeux, D., additional, Lemonnier, N., additional, Lowe, L.A., additional, Lutter, R., additional, Manta, A., additional, Mazein, A., additional, McEvoy, L., additional, Menzies-Gow, A., additional, Mores, N., additional, Murray, C.S., additional, Nething, K., additional, Nihlén, U., additional, Niven, R., additional, Nordlund, B., additional, Nsubuga, S., additional, Pellet, J., additional, Pison, C., additional, Praticò, G., additional, Puig Valls, M., additional, Riemann, K., additional, Rocha, J.P., additional, Rossios, C., additional, Santini, G., additional, Sagi, M., additional, Scott, S., additional, Sehgal, N., additional, Selby, A., additional, Söderman, P., additional, Sogbesan, A., additional, Spycher, F., additional, Stephan, S., additional, Stokholm, J., additional, Sunther, M., additional, Szentkereszty, M., additional, Tamasi, L., additional, Tariq, K., additional, Valente, S, additional, Van Aalderen, W.M., additional, Van Drunen, C.M., additional, Van Eyll, J., additional, Vyas, A., additional, Yu, W., additional, Zetterguist, W., additional, Zolkipli, Z., additional, Zwinderman, A.H., additional, Agusti, A., additional, Wedzicha, J.A., additional, Donaldson, G.C., additional, Faner, R., additional, Breyer-Kohansal, R., additional, Maitland-van der Zee, A.H., additional, Melén, E., additional, Allinson, J.P., additional, Vanfleteren, L.E.G.W., additional, Vestbo, J., additional, Adcock, I.M., additional, Lahousse, L., additional, Van den Berge, M., additional, Alter, P., additional, Barbe, F., additional, Brightling, C.E., additional, Breyer, M.K., additional, Burghuber, O.C., additional, Casas, M., additional, Chung, K.F., additional, Cosío, B.G., additional, Crispi, F., additional, De Batlle, J., additional, Fitting, J.W., additional, Garcia, J., additional, Hallberg, J., additional, Hartl, S., additional, Jarvis, D., additional, Mathioudakis, A., additional, Nicod, L., additional, Papi, A., additional, Ritchie, A., additional, Sigsgaard, T., additional, Sterk, P.J., additional, Ullman, A., additional, Vellvé, K., additional, Vogelmeier, C., additional, Wheelock, A.M., additional, and Wheelock, C.E., additional
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- 2023
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36. Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study
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Sjödin, Marcus O. D., Checa, Antonio, Yang, Mingxing, Dahlén, Sven-Erik, Wheelock, Åsa M., Eklund, Anders, Grunewald, Johan, and Wheelock, Craig E.
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- 2018
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37. Prostaglandin E2 inhibits mast cell–dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor
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Säfholm, Jesper, Manson, Martijn L., Bood, Johan, Delin, Ingrid, Orre, Ann-Charlotte, Bergman, Per, Al-Ameri, Mamdoh, Dahlén, Sven-Erik, and Adner, Mikael
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- 2015
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38. The association between asthma and rhinitis is stable over time despite diverging trends in prevalence
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Bjerg, Anders, Eriksson, Jonas, Ólafsdóttir, Inga Sif, Middelveld, Roelinde, Franklin, Karl, Forsberg, Bertil, Larsson, Kjell, Torén, Kjell, Dahlén, Sven-Erik, and Janson, Christer
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- 2015
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39. Household Costs Associated with Objectively Diagnosed Allergy to Staple Foods in Children and Adolescents
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Protudjer, Jennifer L.P., Jansson, Sven-Arne, Heibert Arnlind, Marianne, Bengtsson, Ulf, Kallström-Bengtsson, Ingrid, Marklund, Birgitta, Middelveld, Roelinde, Rentzos, Georgios, Sundqvist, Ann-Charlotte, Åkerström, Johanna, Östblom, Eva, Dahlén, Sven-Erik, and Ahlstedt, Staffan
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- 2015
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40. H influenzae & M catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation
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Chung, Kian Fan, primary, Versi, Ali, additional, Ivan, Fransiskus Xaverius, additional, Ibrahim, Mahmoud, additional, Bates, Stewart, additional, Riley, John, additional, Baribaud, Frederic, additional, Kermani, Nazanin Zounemat, additional, Montuschi, Paolo, additional, Dahlén, Sven-Erik, additional, Djukanovic, Ratko, additional, Sterk, Peter, additional, Zee, Anke-Hilse Maitland-van der, additional, Chotirmall, Sanjay Haresh, additional, Howarth, Peter, additional, and Adcock, Ian, additional
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- 2022
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41. Identifying and appraising outcome measures for severe asthma: a systematic review
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Rattu, Anna, primary, Khaleva, Ekaterina, additional, Brightling, Chris, additional, Dahlén, Sven-Erik, additional, Bossios, Apostolos, additional, Fleming, Louise, additional, Chung, Kian Fan, additional, Melén, Erik, additional, Djukanovic, Ratko, additional, Chaudhuri, Rekha, additional, Exley, Andrew, additional, Koppelman, Gerard H., additional, Bourdin, Arnaud, additional, Rusconi, Franca, additional, Porsbjerg, Celeste, additional, Coleman, Courtney, additional, Williams, Clare, additional, Nielsen, Hanna, additional, Davin, Elizabeth, additional, Taverner, Phil, additional, Romagosa Vilarnau, Sofia, additional, and Roberts, Graham, additional
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- 2022
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42. Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
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Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven-Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J, Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H, Melén, Erik, Murray, Clare S, Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C, Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W, Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A, Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G, Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke H, Mahler, Vera, and Roberts, Graham
- Abstract
BACKGROUND: Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) working group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies.METHODS: COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult, and paediatric clinicians, pharmaceutical representatives and health regulators from across Europe. Evidence included a systematic review of development, validity, and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients' and carers' views about outcome measures. It was discussed using a modified GRADE Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria.RESULTS: Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire, and Asthma Control Test (ACT) or Childhood-ACT while the adult COM includes the Severe Asthma Questionnaire and the Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately).CONCLUSIONS: This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.
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- 2022
43. Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
- Author
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Khaleva, Ekaterina, primary, Rattu, Anna, additional, Brightling, Chris, additional, Bush, Andrew, additional, Bossios, Apostolos, additional, Bourdin, Arnaud, additional, Chung, Kian Fan, additional, Chaudhuri, Rekha, additional, Coleman, Courtney, additional, Dahlén, Sven-Erik, additional, Djukanovic, Ratko, additional, Deschildre, Antoine, additional, Fleming, Louise, additional, Fowler, Stephen J., additional, Gupta, Atul, additional, Hamelmann, Eckard, additional, Hashimoto, Simone, additional, Hedlin, Gunilla, additional, Koppelman, Gerard H., additional, Melén, Erik, additional, Murray, Clare S., additional, Pilette, Charles, additional, Porsbjerg, Celeste, additional, Pike, Katharine C., additional, Rusconi, Franca, additional, Williams, Clare, additional, Ahrens, Birgit, additional, Alter, Peter, additional, Anckers, Freja, additional, van den Berge, Maarten, additional, Blumchen, Katharina, additional, Brusselle, Guy, additional, Clarke, Graham W., additional, Cunoosamy, Danen, additional, Dahlén, Barbro, additional, Dixey, Piers, additional, Exley, Andrew, additional, Frey, Urs, additional, Gaillard, Erol A., additional, Giovannini-Chami, Lisa, additional, Grigg, Jonathan, additional, Hartenstein, Diana, additional, Heaney, Liam G., additional, Karadag, Bülent, additional, Kaul, Susanne, additional, Kull, Inger, additional, Licari, Amelia, additional, Maitland-van der Zee, Anke H., additional, Mahler, Vera, additional, Schoos, Ann-Marie M., additional, Nagakumar, Prasad, additional, Negus, Jenny, additional, Nielsen, Hanna, additional, Paton, James, additional, Pijnenburg, Mariëlle, additional, Ramiconi, Valeria, additional, Romagosa Vilarnau, Sofia, additional, Principe, Stefania, additional, Rutjes, Niels, additional, Saglani, Sejal, additional, Seddon, Paul, additional, Singer, Florian, additional, Staudinger, Heribert, additional, Turner, Steve, additional, Vijverberg, Susanne, additional, Winders, Tonya, additional, Yasinska, Valentyna, additional, and Roberts, Graham, additional
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- 2022
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44. Reply: U-BIOPRED/BIOAIR proteins: inflammation or infection?
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Sparreman Mikus, Maria, primary, Kolmert, Johan, additional, Andersson, Lars I., additional, Dahlén, Sven-Erik, additional, and James, Anna, additional
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- 2022
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45. Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma
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Daham, Kameran, James, Anna, Balgoma, David, Kupczyk, Maciej, Billing, Bo, Lindeberg, Agneta, Henriksson, Elisabeth, FitzGerald, Garret A., Wheelock, Craig E., Dahlén, Sven-Erik, and Dahlén, Barbro
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- 2014
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46. Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers
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Brandsma, Joost, Goss, Victoria M., Yang, Xian, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Dahlén, Sven-Erik, Fowler, Stephen J., Horvath, Ildiko, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Shaw, Dominick E., Chung, Kian Fan, Singer, Florian, Fleming, Louise J., Sousa, Ana R., Pandis, Ioannis, Bansal, Aruna T., Sterk, Peter J., Djukanović, Ratko, Postle, Anthony D., and The U-BIOPRED Study Group
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- 2018
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47. Phenotypic predictors of response to oral glucocorticosteroids in severe asthma
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Kupczyk, Maciej, Haque, Shushila, Middelveld, Roelinde J.M., Dahlén, Barbro, and Dahlén, Sven-Erik
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- 2013
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48. Refractoriness to Exercise Challenge: A Review of the Mechanisms Old and New
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Larsson, Johan, Anderson, Sandra D., Dahlén, Sven-Erik, and Dahlén, Barbro
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- 2013
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49. The Contraction of the Human Pulmonary Artery by LTC4 is Resistant to CYSLT1 Antagonists and Counteracted by Prostacyclin Release
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Bäck, Magnus, Norel, Xavier, Walch, Laurence, Gascard, Jean-Pierre, Dahlén, Sven-Erik, Brink, Charles, Honn, Kenneth V., editor, Marnett, Lawrence J., editor, Nigam, Santosh, editor, Dennis, Edward, editor, and Serhan, Charles, editor
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- 2002
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50. Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study
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Reinke, Stacey N., Naz, Shama, Chaleckis, Romanas, Gallart-Ayala, Hector, Kolmert, Johan, Kermani, Nazanin Z., Tiotiu, Angelica, Broadhurst, David I., Lundqvist, Anders, Olsson, Henric, Ström, Marika, Wheelock, Åsa M, Gómez, Cristina, Ericsson, Magnus, Sousa, Ana R., Riley, John H., Bates, Stewart, Scholfield, James, Loza, Matthew, Baribaud, Frédéric, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter, Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Behndig, Annelie F., Singer, Florian, Musial, Jacek, Shaw, Dominick E., Dahlén, Barbro, Hu, Sile, Lasky-Su, Jessica, Sterk, Peter J., Chung, Kian Fan, Djukanovic, Ratko, Dahlén, Sven-Erik, Adcock, Ian M., Wheelock, Craig E., Reinke, Stacey N., Naz, Shama, Chaleckis, Romanas, Gallart-Ayala, Hector, Kolmert, Johan, Kermani, Nazanin Z., Tiotiu, Angelica, Broadhurst, David I., Lundqvist, Anders, Olsson, Henric, Ström, Marika, Wheelock, Åsa M, Gómez, Cristina, Ericsson, Magnus, Sousa, Ana R., Riley, John H., Bates, Stewart, Scholfield, James, Loza, Matthew, Baribaud, Frédéric, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J., Geiser, Thomas, Howarth, Peter, Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Behndig, Annelie F., Singer, Florian, Musial, Jacek, Shaw, Dominick E., Dahlén, Barbro, Hu, Sile, Lasky-Su, Jessica, Sterk, Peter J., Chung, Kian Fan, Djukanovic, Ratko, Dahlén, Sven-Erik, Adcock, Ian M., and Wheelock, Craig E.
- Abstract
INTRODUCTION: Asthma is a heterogeneous disease with poorly defined phenotypes. Patients with severe asthma often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, rendering it challenging to investigate underlying disease mechanisms. Here, we aimed to identify dysregulated metabolic processes in relation to asthma severity and medication. METHODS: Baseline urine was collected prospectively from healthy participants (n=100), patients with mild-to-moderate asthma (n=87) and patients with severe asthma (n=418) in the cross-sectional U-BIOPRED cohort; 12-18-month longitudinal samples were collected from patients with severe asthma (n=305). Metabolomics data were acquired using high-resolution mass spectrometry and analysed using univariate and multivariate methods. RESULTS: A total of 90 metabolites were identified, with 40 significantly altered (p<0.05, false discovery rate <0.05) in severe asthma and 23 by OCS use. Multivariate modelling showed that observed metabotypes in healthy participants and patients with mild-to-moderate asthma differed significantly from those in patients with severe asthma (p=2.6×10-20), OCS-treated asthmatic patients differed significantly from non-treated patients (p=9.5×10-4), and longitudinal metabotypes demonstrated temporal stability. Carnitine levels evidenced the strongest OCS-independent decrease in severe asthma. Reduced carnitine levels were associated with mitochondrial dysfunction via decreases in pathway enrichment scores of fatty acid metabolism and reduced expression of the carnitine transporter SLC22A5 in sputum and bronchial brushings. CONCLUSIONS: This is the first large-scale study to delineate disease- and OCS-associated metabolic differences in asthma. The widespread associations with different therapies upon the observed metabotypes demonstrate the need to evaluate potential modulating effects on a treatment- and metabolite-specific basis. Altered carn
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- 2022
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