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2. Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies

Author

Stein, Sydney R., Ramelli, Sabrina C., Ramos-Benitez, Marcos J., Platt, Andrew P., Dickey, James M., Curran, Shelly J., Babyak, Ashley L., Valencia, Luis Perez, Richert, Mary E., Vannella, Kevin M., Chertow, Daniel S., Kleiner, David E., Hewitt, Stephen M., Young, Willie J., Young, Sarah P., Gasmi, Billel, De Melo, Michelly Sampaio, Desar, Sabina, Tadros, Saber, Nasir, Nadia, Jin, Xueting, Rajan, Sharika, Dikoglu, Esra, Ozkaya, Neval, Ylaya, Kris, Chung, Joon-Yong, Pittaluga, Stefania, Smith, Grace, Emanuel, Elizabeth R., Kelsall, Brian, Olivera, Justin A., Blawas, Megan, Grazioli, Alison, Hays, Nicole, Purcell, Madeleine, Singireddy, Shreya, Wu, Jocelyn, Raja, Katherine, Curto, Ryan, Chung, Jean, Borth, Amy, Bowers, Kimberly, Weichold, Anne, Minor, Paula, Moshref, Mirahmad, Kelly, Emily, Sajadi, Mohammad M., Scalea, Thomas M., Tran, Douglas, Madathil, Ronson J., Dahi, Siamak, Deatrick, Kristopher B., Krause, Eric M., Rabin, Joseph, Herrold, Joseph A., Tabatabai, Ali, Hochberg, Eric, Cornachione, Christopher, Levine, Andrea R., Saharia, Kapil K., Richards, Justin E., Elder, John, Burke, Allen, Mazzeffi, Michael A., Christenson, Robert, Chancer, Zackary, Abdulmahdi, Mustafa, Sopha, Sabrina, Goldberg, Tyler, Soherwardi, Shahabuddin, Sangwan, Yashvir, McCurdy, Michael T., Sudano, Kristen, Blume, Diane, Radin, Bethany, Arnouk, Madhat, Eagan, James W., Jr., Herr, Daniel L., Zerbe, Christa, Sen, H. Nida, Wang, Yujuan, Kodati, Shilpa, Lee, Jung Wha, Perez, Paola, Singh, Manmeet, Yinda, Kwe Claude, Platt, Andrew, Munster, Vincent J., de Wit, Emmie, Warner, Blake M., and Chan, Chi-Chao

Published
2023
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4. Left ventricular systolic dysfunction during acute pulmonary embolism

Author

Cires-Drouet, Rafael, LaRocco, Allison, Soldin, Danielle, John, Thomas, Toursavadkohi, Shahab, Nagarsheth, Khanjan, Dahi, Siamak, Marsella, Justin, Mayorga-Carlin, Minerva, Sorkin, John D., Jones, Kevin, Haase, Daniel, Hong, Susie N., Lal, Brajesh K., Griffith, Bartley, Ramani, Gautam, and Taylor, Bradley

Published
2023
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7. Triage of V‐V ECMO referrals for COVID‐19 respiratory failure

Author

Niles, Erin, primary, Haase, Daniel J., additional, Tran, Quincy, additional, Gerding, James A., additional, Esposito, Emily, additional, Dahi, Siamak, additional, Galvagno, Samuel M., additional, Boswell, Kimberly, additional, Rector, Raymond, additional, Pearce, Robert, additional, Abdel‐Wahab, Maie, additional, Singh, Aditi, additional, Pirzada, Saad, additional, Tabatabai, Ali, additional, and Powell, Elizabeth K., additional

Published
2024
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8. Venoarterial Extracorporeal Membrane Oxygenation With or Without Advanced Intervention for Massive Pulmonary Embolism.

Author

Cardona, Stephanie, Downing, Jessica V, Witting, Michael D, Haase, Daniel J, Powell, Elizabeth K, Dahi, Siamak, Pasrija, Chetan, and Tran, Quincy K

Subjects
PULMONARY embolism, PEARSON correlation (Statistics), STATISTICAL correlation, EXTRACORPOREAL membrane oxygenation, THROMBOLYTIC therapy, ACADEMIC medical centers, RECEIVER operating characteristic curves, KRUSKAL-Wallis Test, MULTIPLE regression analysis, LOGISTIC regression analysis, PROBABILITY theory, QUESTIONNAIRES, DISCHARGE planning, TREATMENT effectiveness, RETROSPECTIVE studies, CHI-squared test, DESCRIPTIVE statistics, EMBOLISMS, VASCULAR surgery, ODDS ratio, MEDICAL records, ACQUISITION of data, LIFE support systems in critical care, RESEARCH, STATISTICS, RESEARCH methodology, CONFIDENCE intervals, COMPARATIVE studies, DATA analysis software, SURVIVAL analysis (Biometry), ALGORITHMS
Abstract

Introduction: Massive pulmonary embolism (MPE) is a rare but highly fatal condition. Our study's objective was to evaluate the association between advanced interventions and survival among patients with MPE treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO). Methods: This is a retrospective review of the Extracorporeal Life Support Organization (ELSO) registry data. We included adult patients with MPE who were treated with VA-ECMO during 2010–2020. Our Primary outcome was survival to hospital discharge; secondary outcomes were ECMO duration among survivors and rates of ECMO-related complications. Clinical variables were compared using the Pearson chi-square and Kruskal-Wallis H tests. Results: We included 802 patients; 80 (10%) received SPE and 18 (2%) received CDT. Overall, 426 (53%) survived to discharge; survival was not significantly different among those treated with SPE or CDT on VA-ECMO (70%) versus VA-ECMO alone (52%) or SPE or CDT before VA-ECMO (52%). Multivariable regression found a trend towards increased survival among those treated with SPE or CDT while on ECMO (AOR 1.8, 95% CI 0.9–3.6), but no significant correlation. There was no association between advanced interventions and ECMO duration among survivors, or rates of ECMO-related complications. Conclusion: Our study found no difference in survival in patients with MPE who received advanced interventions prior to ECMO, and a slight non-significant benefit in those who received advanced interventions while on ECMO. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood

Author

Burdorf, Lars, primary, Gao, Zhuo, additional, Riner, Andrea, additional, Sievert, Evelyn, additional, Harris, Donald G., additional, Kuravi, Kasinath V., additional, Morrill, Benson H., additional, Habibabady, Zahra, additional, Rybak, Elana, additional, Dahi, Siamak, additional, Zhang, Tianshu, additional, Schwartz, Evan, additional, Kang, Elizabeth, additional, Cheng, Xiangfei, additional, Esmon, Charles T., additional, Phelps, Carol J., additional, Ayares, David L., additional, III, Richard N. Pierson, additional, and Azimzadeh, Agnes M., additional

Published
2023
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10. Functional Recovery in a Cohort of ECMO and Non-ECMO Acute Respiratory Distress Syndrome Survivors

Author

Snyder, Mackenzie, primary, Njie, Binta, additional, Grabenstein, Ilana, additional, Viola, Sara, additional, Abbas, Hatoon, additional, Bhatti, Waqas, additional, Lee, Ryan, additional, Yeung, Siu Yan Amy, additional, Chow, Jonathan H., additional, Tabatabai, Ali, additional, Taylor, Bradley S., additional, Dahi, Siamak, additional, Scalea, Thomas, additional, Rabin, Joseph, additional, Grazioli, Alison, additional, Calfee, Carolyn S., additional, Britton, Noel, additional, and Levine, Andrea R., additional

Published
2023
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11. Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood

Author

Chaban, Ryan, primary, McGrath, Gannon, additional, Habibabady, Zahra, additional, Rosales, Ivy, additional, Burdorf, Lars, additional, Ayares, David L., additional, Rybak, Elana, additional, Zhang, Tianshu, additional, Harris, Donald G., additional, Dahi, Siamak, additional, Ali, Franchesca, additional, Parsell, Dawn M., additional, Braileanu, Gheorghe, additional, Cheng, Xiangfei, additional, Sievert, Evelyn, additional, Phelps, Carol, additional, Azimzadeh, Agnes M., additional, and Pierson, Richard N., additional

Published
2023
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13. Decreased PRESET-Score corresponds with improved survival in COVID-19 veno-venous extracorporeal membrane oxygenation.

Author

Powell, Elizabeth K, Lankford, Allison S, Ghneim, Mira, Rabin, Joseph, Haase, Daniel J, Dahi, Siamak, Deatrick, Kristopher B, Krause, Eric, Bittle, Gregory, Galvagno Jr, Samuel M, Scalea, Thomas, and Tabatabai, Ali

Subjects
COVID-19, CONFIDENCE intervals, MULTIPLE regression analysis, EXTRACORPOREAL membrane oxygenation, RETROSPECTIVE studies, ADULT respiratory distress syndrome, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, ODDS ratio, DATA analysis software, OVERALL survival, COMORBIDITY
Abstract

Introduction: The PREdiction of Survival on ECMO Therapy Score (PRESET-Score) predicts mortality while on veno-venous extracorporeal membrane oxygenation (VV ECMO) for acute respiratory distress syndrome. The aim of our study was to assess the association between PRESET-Score and survival in a large COVID-19 VV ECMO cohort. Methods: This was a single-center retrospective study of COVID-19 VV ECMO patients from 15 March 2020, to 30 November 2021. Univariable and Multivariable analyses were performed to assess patient survival and score differences. Results: A total of 105 patients were included in our analysis with a mean PRESET-Score of 6.74. Overall survival was 65.71%. The mean PRESET-Score was significantly lower in the survivor group (6.03 vs 8.11, p < 0.001). Patients with a PRESET-Score less than or equal to six had improved survival compared to those with a PRESET-Score greater than or equal to 8 (97.7% vs. 32.5%, p < 0.001). In a multivariable logistic regression, a lower PRESET-Score was also predictive of survival (OR 2.84, 95% CI 1.75, 4.63, p < 0.001). Conclusion: We demonstrate that lower PRESET scores are associated with improved survival. The utilization of this validated, quantifiable, and objective scoring system to help identify COVID-19 patients with the greatest potential to benefit from VV-ECMO appears feasible. The incorporation of the PRESET-Score into institutional ECMO candidacy guidelines can help insure and improve access of this limited healthcare resource to all critically ill patients. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Histopathology and SARS-CoV-2 cellular localization in eye tissues of COVID-19 autopsies

Author

Sen, H. Nida, primary, Vannella, Kevin M., additional, Wang, Yujuan, additional, Chung, Joon-Yong, additional, Kodati, Shilpa, additional, Ramelli, Sabrina C., additional, Lee, Jung Wha, additional, Perez, Paola, additional, Stein, Sydney R., additional, Grazioli, Alison, additional, Dickey, James M., additional, Ylaya, Kris, additional, Singh, Manmeet, additional, Yinda, Kwe Claude, additional, Platt, Andrew, additional, Ramos-Benitez, Marcos J., additional, Zerbe, Christa, additional, Munster, Vincent J., additional, de Wit, Emmie, additional, Warner, Blake M, additional, Herr, Daniel L., additional, Rabin, Joseph, additional, Saharia, Kapil K, additional, Kleiner, David E., additional, Hewitt, Stephen M., additional, Chan, Chi-Chao, additional, Chertow, Daniel S., additional, Platt, Andrew P., additional, Curran, Shelly J., additional, Babyak, Ashley L., additional, Valencia, Luis Perez, additional, Richert, Mary E., additional, Young, Willie J., additional, Young, Sarah P., additional, Gasmi, Billel, additional, De Melo, Michelly Sampaio, additional, Desar, Sabina, additional, Tadros, Saber, additional, Nasir, Nadia, additional, Jin, Xueting, additional, Rajan, Sharika, additional, Dikoglu, Esra, additional, Ozkaya, Neval, additional, Pittaluga, Stefania, additional, Smith, Grace, additional, Emanuel, Elizabeth R., additional, Kelsall, Brian, additional, Olivera, Justin A., additional, Blawas, Megan, additional, Hays, Nicole, additional, Purcell, Madeleine, additional, Singireddy, Shreya, additional, Wu, Jocelyn, additional, Raja, Katherine, additional, Curto, Ryan, additional, Chung, Jean, additional, Borth, Amy, additional, Bowers, Kimberly, additional, Weichold, Anne, additional, Minor, Paula, additional, Moshref, Mirahmad, additional, Kelly, Emily, additional, Sajadi, Mohammad M., additional, Scalea, Thomas M., additional, Tran, Douglas, additional, Madathil, Ronson J., additional, Dahi, Siamak, additional, Deatrick, Kristopher B., additional, Krause, Eric M., additional, Herrold, Joseph A., additional, Tabatabai, Ali, additional, Hochberg, Eric, additional, Cornachione, Christopher, additional, Levine, Andrea R., additional, Saharia, Kapil K., additional, Richards, Justin E., additional, Elder, John, additional, Burke, Allen, additional, Mazzeffi, Michael A., additional, Christenson, Robert, additional, Chancer, Zackary, additional, Abdulmahdi, Mustafa, additional, Sopha, Sabrina, additional, Goldberg, Tyler, additional, Soherwardi, Shahabuddin, additional, Sangwan, Yashvir, additional, McCurdy, Michael T., additional, Sudano, Kristen, additional, Blume, Diane, additional, Radin, Bethany, additional, Arnouk, Madhat, additional, and Eagan, James W., additional

Published
2023
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18. Supplemental material - Venoarterial extracorporeal membrane oxygenation with or without advanced intervention for massive pulmonary embolism

Author

Cardona, Stephanie, Downing, Jessica V, Witting, Michael D, Haase, Daniel J, Powell, Elizabeth K, Dahi, Siamak, Pasrija, Chetan, and Tran, Quincy K

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material for Venoarterial extracorporeal membrane oxygenation with or without advanced intervention for massive pulmonary embolism by Stephanie Cardona, Jessica V Downing, Michael D Witting, Daniel J Haase, Elizabeth K Powell, Siamak Dahi, Chetan Pasrija and Quincy K Tran in Perfusion

Published
2023
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20. Veno-arterial extracorporeal membrane oxygenation without allogeneic blood transfusion: An observational cohort study.

Author

Grazioli, Alison, Plazak, Michael, Dahi, Siamak, Rabin, Joseph, Menne, Ashley, Ghoreishi, Mehrdad, Taylor, Bradley, Perelman, Seth, and Mazzeffi, Michael

Subjects
HYPERTENSION, ACADEMIC medical centers, SCIENTIFIC observation, HEMOGLOBINS, BLOOD transfusion, EXTRACORPOREAL membrane oxygenation, RETROSPECTIVE studies, MANN Whitney U Test, FISHER exact test, HOSPITAL mortality, COMPARATIVE studies, T-test (Statistics), CARDIOGENIC shock, CORONARY artery disease, DESCRIPTIVE statistics, CHI-squared test, HEMATOPOIETIC stem cell transplantation, DATA analysis software, LONGITUDINAL method, HEMORRHAGE, DISEASE complications
Abstract

Introduction: It remains unclear whether patients who will not accept allogeneic blood transfusion can be managed successfully with veno-arterial (V-A) extracorporeal membrane oxygenation (ECMO). The objective of our study was to determine what percentage of V-A ECMO patients were managed without allogeneic blood transfusion. Methods: This was a retrospective, observational cohort study of patients with cardiogenic shock requiring V-A ECMO between January 2016 and January 2019. The primary outcome was avoidance of any allogeneic blood transfusion. Results: Of the 206 patients included, 23 (11.2%) were managed without any allogeneic blood transfusion. Fourteen (60.9%) avoided allogeneic blood transfusion during their entire hospitalization. "No-transfusion" patients were younger, more commonly men, were less likely to have a prior diagnosis of hypertension or coronary artery disease, had higher baseline hemoglobin, had higher SAVE scores, and were less likely to have received aspirin before ECMO. No patients in the "no-transfusion" group had major bleeding compared to 35% of patients in the blood transfusion group (p < 0.001). In-hospital mortality was 17.4% for those who avoided blood transfusion and 41.5% for those who received blood transfusion (p = 0.04). ECMO duration was significantly shorter in patients who avoided blood transfusion compared to those who received blood transfusion (median 3.5 vs 7 days, p < 0.001). Conclusions: Select patients can be successfully managed on V-A ECMO without allogeneic blood transfusion. Jehovah's Witnesses and other patients with objections to allogeneic transfusion might be offered V-A ECMO if its anticipated duration is short (e.g. <7 days) and baseline hemoglobin concentration is high (e.g. ≥10 mg/dL). [ABSTRACT FROM AUTHOR]

Published
2023
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21. Body mass index does not impact survival in COVID-19 patients requiring veno-venous extracorporeal membrane oxygenation.

Author

Powell, Elizabeth K, Haase, Daniel J, Lankford, Allison, Boswell, Kimberly, Esposito, Emily, Hamera, Joseph, Dahi, Siamak, Krause, Eric, Bittle, Gregory, Deatrick, Kristopher B, Young, Bree Ann C, Galvagno Jr, Samuel M, and Tabatabai, Ali

Subjects
ADULT respiratory distress syndrome treatment, OBESITY, STATISTICS, KRUSKAL-Wallis Test, COVID-19, CONFIDENCE intervals, MULTIVARIATE analysis, EXTRACORPOREAL membrane oxygenation, RETROSPECTIVE studies, ACQUISITION of data, HOSPITAL mortality, SEVERITY of illness index, COMPARATIVE studies, MEDICAL records, DESCRIPTIVE statistics, BODY mass index, LOGISTIC regression analysis, ODDS ratio, DATA analysis software, BLOOD filtration
Abstract

Introduction: With the increased demand for veno-venous extracorporeal membrane oxygenation (VV ECMO) during the COVID-19 pandemic, guidelines for patient candidacy have often limited this modality for patients with a body mass index (BMI) less than 40 kg/m2. We hypothesize that COVID-19 VV ECMO patients with at least class III obesity (BMI ≥ 40) have decreased in-hospital mortality when compared to non-COVID-19 and non-class III obese COVID-19 VV ECMO populations. Methods: This is a single-center retrospective study of COVID-19 VV ECMO patients from January 1, 2014, to November 30, 2021. Our institution used BMI ≥ 40 as part of a multi-disciplinary VV ECMO candidate screening process in COVID-19 patients. BMI criteria were not considered for exclusion criteria in non-COVID-19 patients. Univariate and multivariable analyses were performed to assess in-hospital mortality differences. Results: A total of 380 patients were included in our analysis: The COVID-19 group had a lower survival rate that was not statistically significant (65.7% vs.74.9%, p =.07). The median BMI between BMI ≥ 40 COVID-19 and non-COVID-19 patients was not different (44.5 vs 45.5, p =.2). There was no difference in survival between the groups (73.3% vs. 78.5%, p =.58), nor was there a difference in survival between the COVID-19 BMI ≥ 40 and BMI < 40 patients (73.3, 62.7, p =.29). Multivariable logistic regression with the outcome of in-hospital mortality was performed and BMI was not found to be significant (OR 0.99, 95% CI 0.89, 1.01; p =.92). Conclusion: BMI ≥ 40 was not an independent risk factor for decreased in-hospital survival in this cohort of VV ECMO patients at a high-volume center. BMI should not be the sole factor when deciding VV ECMO candidacy in patients with COVID-19. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Decreased PRESET-Score corresponds with improved survival in COVID-19 veno-venous extracorporeal membrane oxygenation

Author

Powell, Elizabeth K, primary, Lankford, Allison S, additional, Ghneim, Mira, additional, Rabin, Joseph, additional, Haase, Daniel J, additional, Dahi, Siamak, additional, Deatrick, Kristopher B, additional, Krause, Eric, additional, Bittle, Gregory, additional, Galvagno, Samuel M, additional, Scalea, Thomas, additional, and Tabatabai, Ali, additional

Published
2022
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25. Body mass index does not impact survival in COVID-19 patients requiring veno-venous extracorporeal membrane oxygenation

Author

Powell, Elizabeth K, primary, Haase, Daniel J, additional, Lankford, Allison, additional, Boswell, Kimberly, additional, Esposito, Emily, additional, Hamera, Joseph, additional, Dahi, Siamak, additional, Krause, Eric, additional, Bittle, Gregory, additional, Deatrick, Kristopher B, additional, Young, Bree Ann C, additional, Galvagno, Samuel M, additional, and Tabatabai, Ali, additional

Published
2022
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26. Supplemental Material - Decreased PRESET score corresponds with improved survival in COVID-19 veno-venous extracorporeal membrane oxygenation

Author

Powell, Elizabeth K, Lankford, Allison S, Ghneim, Mira, Rabin, Joseph, Haase, Daniel J, Dahi, Siamak, Deatrick, Kristopher B, Krause, Eric, Bittle, Gregory, Galvagno, Samuel M, Scalea, Thomas, and Tabatabai, Ali

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental Material for Decreased PRESET score corresponds with improved survival in COVID-19 veno-venous extracorporeal membrane oxygenation by Elizabeth K Powell, Allison S Lankford, Mira Ghneim, Joseph Rabin, Daniel J Haase, Siamak Dahi, Kristopher B Deatrick, Eric Krause, Gregory Bittle, Samuel M Galvagno Jr, Thomas Scalea and Ali Tabatabai in Perfusion

Published
2022
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27. New-onset atrial arrhythmias are independently associated with in-hospital mortality in veno-venous extracorporeal membrane oxygenation

Author

Li, Cecilia, primary, Pajoumand, Mehrnaz, additional, Lambert, Kerry, additional, Najia, Laila, additional, Bathula, Allison L., additional, Mazzeffi, Michael A., additional, Galvagno, Samuel M., additional, Tabatabai, Ali, additional, Grazioli, Alison, additional, Dahi, Siamak, additional, Hochberg, Eric S., additional, and Plazak, Michael E., additional

Published
2021
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30. A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part II: Clinical Management

Author

Shah, Aakash, primary, Dave, Sagar, additional, Galvagno, Samuel, additional, George, Kristen, additional, Menne, Ashley R., additional, Haase, Daniel J., additional, McCormick, Brian, additional, Rector, Raymond, additional, Dahi, Siamak, additional, Madathil, Ronson J., additional, Deatrick, Kristopher B., additional, Ghoreishi, Mehrdad, additional, Gammie, James S., additional, Kaczorowski, David J., additional, Scalea, Thomas M., additional, Menaker, Jay, additional, Herr, Daniel, additional, Tabatabai, Ali, additional, and Krause, Eric, additional

Published
2021
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31. A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part I: System Planning and Care Teams

Author

Dave, Sagar, primary, Shah, Aakash, additional, Galvagno, Samuel, additional, George, Kristen, additional, Menne, Ashley R., additional, Haase, Daniel J., additional, McCormick, Brian, additional, Rector, Raymond, additional, Dahi, Siamak, additional, Madathil, Ronson J., additional, Deatrick, Kristopher B., additional, Ghoreishi, Mehrdad, additional, Gammie, James S., additional, Kaczorowski, David J., additional, Scalea, Thomas M., additional, Menaker, Jay, additional, Herr, Daniel, additional, Krause, Eric, additional, and Tabatabai, Ali, additional

Published
2021
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33. Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood

Author

Burdorf, Lars, primary, Harris, Donald, additional, Dahi, Siamak, additional, Laird, Christopher, additional, Zhang, Tianshu, additional, Ali, Franchesca, additional, Shah, Aakash, additional, Thompson, Mercedes, additional, Braileanu, Gheorghe, additional, Cheng, Xiangfei, additional, Sievert, Evelyn, additional, Schwartz, Evan, additional, Sendil, Selin, additional, Parsell, Dawn M., additional, Redding, Emily, additional, Phelps, Carol J., additional, Ayares, David L., additional, Azimzadeh, Agnes M., additional, and Pierson, Richard N., additional

Published
2018
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34. Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model

Author

O'Neill, Natalie A., primary, Zhang, Tianshu, additional, Braileanu, Gheorghe, additional, Sun, Wenji, additional, Cheng, Xiangfei, additional, Hershfeld, Alena, additional, Laird, Christopher T., additional, Kronfli, Anthony, additional, Hock, Lindsay A., additional, Dahi, Siamak, additional, Kubicki, Natalia, additional, Sievert, Evelyn, additional, Hassanein, Wessam, additional, Cimeno, Arielle, additional, Pierson, Richard N., additional, and Azimzadeh, Agnes M., additional

Published
2017
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36. Effect of selective CD28 blockade with FR104 alone or combined with CD154 blockade in monkey cardiac allograft transplantation. (TRAN2P.967)

Author

Azimzadeh, Agnes, primary, Zhang, Tianshu, additional, Braileanu, Gheorghe, additional, Sun, Wenji, additional, Kronfli, Anthony, additional, Sievert, Evelyn, additional, Harris, Donald, additional, Parsell, Dawn, additional, Dahi, Siamak, additional, Kubicki, Natalia, additional, Woodall, Jhade, additional, Uluer, Mehmet, additional, Cheng, Xiangfei, additional, Schwartz, Evan, additional, Quinn, Kevin, additional, Vanhove, Bernard, additional, and Pierson, Richard, additional

Published
2015
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37. Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood

Author

Harris, Donald G., primary, Quinn, Kevin J., additional, French, Beth M., additional, Schwartz, Evan, additional, Kang, Elizabeth, additional, Dahi, Siamak, additional, Phelps, Carol J., additional, Ayares, David L., additional, Burdorf, Lars, additional, Azimzadeh, Agnes M., additional, and Pierson, Richard N., additional

Published
2014
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38. Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.

Author

Burdorf, Lars, Harris, Donald, Dahi, Siamak, Laird, Christopher, Zhang, Tianshu, Ali, Franchesca, Shah, Aakash, Thompson, Mercedes, Braileanu, Gheorghe, Cheng, Xiangfei, Sievert, Evelyn, Schwartz, Evan, Sendil, Selin, Parsell, Dawn M., Redding, Emily, Phelps, Carol J., Ayares, David L., Azimzadeh, Agnes M., and Pierson, Richard N.

Subjects
HISTAMINE, VASCULAR resistance, HISTAMINE receptors, PERFUSION, BLOOD platelet activation
Abstract

Background: Elevated pulmonary vascular resistance (PVR), platelet adhesion, coagulation activation, and inflammation are prominent features of xenolung rejection. Here, we evaluate the role of thromboxane and histamine on PVR, and their contribution to other lung xenograft injury mechanisms. Methods: GalTKO.hCD46 single pig lungs were perfused ex vivo with fresh heparinized human blood: lungs were either treated with 1‐Benzylimidazole (1‐BIA) combined with histamine receptor blocker famotidine (n = 4) or diphenhydramine (n = 6), 1‐BIA alone (n = 6) or were left untreated (n = 9). Results: Six of the nine control experiments (GalTKO.hCD46 untreated), "survived" until elective termination at 4 hours. Without treatment, initial PVR elevation within the first 30 minutes resolved partially over the following hour, and increased progressively during the final 2 hours of perfusion. In contrast, 1‐BIA, alone or in addition to either antihistamine treatment, was associated with low stable PVR. Combined treatments significantly lowered the airway pressure when compared to untreated reference. Although platelet and neutrophil sequestration and coagulation cascade activation were not consistently altered by any intervention, increased terminal wet/dry weight ratio in untreated lungs was significantly blunted by combined treatments. Conclusion: Combined thromboxane and histamine pathway blockade prevents PVR elevation and significantly inhibits loss of vascular barrier function when GalTKO.hCD46 lungs are perfused with human blood. Platelet activation and platelet and neutrophil sequestration persist in all groups despite efficient complement regulation, and appear to occur independent of thromboxane and histamine antagonism. Our work identifies thromboxane and histamine as key mediators of xenolung injury and defines those pathways as therapeutic targets to achieve successful xenolung transplantation. [ABSTRACT FROM AUTHOR]

Published
2019
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