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1. Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study

Author

Mokhtar, Sara B. A., Viljoen, Jessica, van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Albers, Jeroen D., Soeterboek, Jens, Scarpa, Fabio, Colonna, Alessia, van der Heide, Frank C. T., van Greevenbroek, Marleen M. J., Bosm, Hans, Kroon, Abraham A., Nuijts, Rudy M. M. A., Gijs, Marlies, Lakerveld, Jeroen, Malik, Rayaz A., Webers, Carroll A. B., Stehouwer, Coen D. A., and Koster, Annemarie

Published
2024
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2. (Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study

Author

Mokhtar, Sara B. A., van der Heide, Frank C. T., Oyaert, Karel A. M., van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Scarpa, Fabio, Colonna, Alessia, de Galan, Bastiaan E., van Greevenbroek, Marleen M. J., Dagnelie, Pieter C., Schalkwijk, Casper G., Nuijts, Rudy M. M. A., Schaper, Nicolaas C., Kroon, Abraham A., Schram, Miranda T., Webers, Carroll A. B., and Stehouwer, Coen D. A.

Published
2023
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3. The association of obesogenic environments with weight status, blood pressure, and blood lipids: A cross-sectional pooled analysis across five cohorts

Author

T Schram, Miranda, Dagnelie, Pieter C., van Greevenbroek, Marleen MJ., Stehouwer, Coen DA., van der Kallen, Carla J., Meijer, Paul, Lam, Thao Minh, Vaartjes, Ilonca, Moll van Charante, Eric, Galenkamp, Henrike, Koster, Annemarie, van den Hurk, Katja, den Braver, Nicole R., Blom, Marieke T., de Jong, Trynke, Grobbee, Diederick E., Beulens, Joline WJ., and Lakerveld, Jeroen

Published
2024
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4. Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study

Author

van der Heide, Frank C. T., Eussen, Simone J. P. M., Houben, Alfons J. H. M., Henry, Ronald M. A., Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Koster, Annemarie, Jansen, Jacobus F. A., Backes, Walter H., Beulens, Joline W. J., and Stehouwer, Coen D. A.

Published
2023
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5. Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study

Author

de Ritter, Rianneke, Sep, Simone J. S., van Greevenbroek, Marleen M. J., Kusters, Yvo H. A. M., Vos, Rimke C., Bots, Michiel L., Kooi, M. Eline, Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Brouwers, Martijn C. G., van der Sangen, Niels M. R., Peters, Sanne A. E., van der Kallen, Carla J. H., and Stehouwer, Coen D. A.

Published
2023
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6. Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study

Author

Tore, Elena C., Elshorbagy, Amany K., Bakers, Frans C. H., Brouwers, Martijn C. G. J., Dagnelie, Pieter C., Eussen, Simone J. P. M., Jansen, Jacobus F. A., Kooi, M. Eline, Kusters, Yvo H. A. M., Meex, Steven J. R., Olsen, Thomas, Refsum, Helga, Retterstøl, Kjetil, Schalkwijk, Casper G., Stehouwer, Coen D. A., Vinknes, Kathrine J., and van Greevenbroek, Marleen M. J.

Published
2023
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10. Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study

Author

Vandercappellen, Evelien J., Koster, Annemarie, Savelberg, Hans H. C. M., Eussen, Simone J. P. M., Dagnelie, Pieter C., Schaper, Nicolaas C., Schram, Miranda T., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Kroon, Abraham A., Henry, Ronald M. A., and Stehouwer, Coen D. A.

Published
2022
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13. (Pre)diabetes, glycemia, and daily glucose variability are associated with retinal nerve fiber layer thickness in The Maastricht Study

Author

van der Heide, Frank C. T., Foreman, Yuri D., Franken, Iris W. M., Henry, Ronald M. A., Kroon, Abraham A., Dagnelie, Pieter C., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., Schram, Miranda T., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Schaper, Nicolaas C., Brouwers, Martijn C. G. J., and Stehouwer, Coen D. A.

Published
2022
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14. Health burden in type 2 diabetes and prediabetes in The Maastricht Study

Author

Veugen, Marja G. J., Onete, Veronica G., Henry, Ronald M. A., Brunner-La Rocca, Hans-Peter, Koster, Annemarie, Dagnelie, Pieter C., Schaper, Nicolaas C., Sep, Simone J. S., van der Kallen, Carla J. H., van Boxtel, Martin P. J., Reesink, Koen D., Schouten, Johannes S., Savelberg, Hans H. C. M., Köhler, Sebastian, Verhey, Frans R., van den Bergh, Joop P. W., Schram, Miranda T., and Stehouwer, Coen D. A.

Published
2022
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15. Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans

Author

Rebelos, Eleni, Daniele, Giuseppe, Campi, Beatrice, Saba, Alessandro, Koskensalo, Kalle, Ihalainen, Jukka, Saukko, Ekaterina, Nuutila, Pirjo, Backes, Walter H., Jansen, Jacobus F. A., Dagnelie, Pieter C., Köhler, Sebastian, de Galan, Bastiaan E., van Sloten, Thomas T., Stehouwer, Coen D. A., and Ferrannini, Ele

Published
2022
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16. Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study.

Author

Mokhtar, Sara B. A., Viljoen, Jessica, van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Albers, Jeroen D., Soeterboek, Jens, Scarpa, Fabio, Colonna, Alessia, van der Heide, Frank C. T., van Greevenbroek, Marleen M. J., Bosm, Hans, Kroon, Abraham A., Nuijts, Rudy M. M. A., Gijs, Marlies, Lakerveld, Jeroen, Malik, Rayaz A., Webers, Carroll A. B., Stehouwer, Coen D. A., and Koster, Annemarie

Subjects
AIR pollutants, TYPE 2 diabetes, PARTICULATE matter, FRACTAL dimensions, AIR pollution
Abstract

Background: Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy. Methods: We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM2.5, PM10, NO2, and EC) and Z-score for individual corneal nerve measures (corneal nerve bifurcation density, corneal nerve density, corneal nerve length, and fractal dimension). Results: After adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM2.5 and PM10 were associated with lower Z-scores for corneal nerve bifurcation density, nerve density, nerve length, and nerve fractal dimension [stβ (95% CI): PM2.5 -0.10 (-0.14; -0.05), -0.04 (-0.09; 0.01), -0.11 (-0.16; -0.06), -0.20 (-0.24; -0.15); and PM10 -0.08 (-0.13; -0.03), -0.04 (-0.09; 0.01), -0.08 (-0.13; -0.04), -0.17 (-0.21; -0.12)], respectively. No associations were found between NO2 and EC and corneal nerve measures. Conclusions: Our population-based study demonstrated that exposure to higher levels of PM2.5 and PM10 are associated with higher levels of corneal neurodegeneration, estimated from lower corneal nerve measures. Our results suggest that air pollution may be a determinant for neurodegeneration assessed in the cornea and may impact the ocular surface health as well. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study

Author

Bakker, Lieke, Ramakers, Inez H. G. B., van Boxtel, Martin P. J., Schram, Miranda T., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Greevenbroek, Marleen M. J., Wesselius, Anke, Midttun, Øivind, Ueland, Per M., Verhey, Frans R. J., Eussen, Simone J. P. M., and Köhler, Sebastian

Published
2021
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18. Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study

Author

Foreman, Yuri D., van Doorn, William P. T. M., Schaper, Nicolaas C., van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Henry, Ronald M. A., Koster, Annemarie, Eussen, Simone J. P. M., Wesselius, Anke, Reesink, Koen D., Schram, Miranda T., Dagnelie, Pieter C., Kroon, Abraham A., Brouwers, Martijn C. G. J., and Stehouwer, Coen D. A.

Published
2021
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19. The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study

Author

Geraets, Anouk F. J., Köhler, Sebastian, Muzambi, Rutendo, Schalkwijk, Casper G., Oenema, Anke, Eussen, Simone J. P. M., Dagnelie, Pieter C., Stehouwer, Coen D. A., Schaper, Nicolaas C., Henry, Ronald M. A., van der Kallen, Carla J. H., Wesselius, Anke, Koster, Annemarie, Verhey, Frans R. J., and Schram, Miranda T.

Published
2020
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20. Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study

Author

de Ritter, Rianneke, Sep, Simone J. S., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., de Jong, Marit, Vos, Rimke C., Bots, Michiel L., Reulen, Jos P. H., Houben, Alfons J. H. M., Webers, Carroll A. B., Berendschot, Tos T. J. M., Dagnelie, Pieter C., Eussen, Simone J. P. M., Schram, Miranda T., Koster, Annemarie, Peters, Sanne A. E., and Stehouwer, Coen D. A.

Published
2021
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21. Initial Imaging-Guided Strategy Versus Routine Care in Patients With Non–ST-Segment Elevation Myocardial Infarction

Author

Smulders, Martijn W., Kietselaer, Bas L.J.H., Wildberger, Joachim E., Dagnelie, Pieter C., Brunner–La Rocca, Hans-Peter, Mingels, Alma M.A., van Cauteren, Yvonne J.M., Theunissen, Ralph A.L.J., Post, Mark J., Schalla, Simon, van Kuijk, Sander M.J., Das, Marco, Kim, Raymond J., Crijns, Harry J.G.M., and Bekkers, Sebastiaan C.A.M.

Published
2019
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23. Retinal Functional and Structural Neural Indices: Potential Biomarkers for the Monitoring of Cerebral Neurodegeneration: The Maastricht Study

Author

van der Heide, Frank C T, Mokhtar, Sara, Khanna, Anjani, Said, Mozhda, Henry, Ronald M A, Kroon, Abraham A, Dagnelie, Pieter C, Eussen, Simone J P M, Berendschot, Tos T J M, Schouten, Jan S A G, Schram, Miranda T, van der Kallen, Carla J H, van Greevenbroek, Marleen M J, Wesselius, Anke, Savelberg, Hans H C M, Schaper, Nicolaas C, Webers, Carroll A B, Stehouwer, Coen D A, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Interne Geneeskunde, RS: MHeNs - R3 - Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: HVC Pieken Maastricht Studie (8), RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Oogheelkunde, MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Nutrition and Movement Sciences, MUMC+: MA Endocrinologie (9), MUMC+: University Eye Center Maastricht (3), MUMC+: *MA Oogheelkunde (3), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), and MUMC+: MA Maag Darm Lever (9)

Subjects
Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology
Abstract

BACKGROUND: If retinal indices of neurodegeneration are to be biomarkers for the monitoring of cerebral neurodegeneration, it is important to establish whether potentially modifiable risk factors for dementia are associated with retinal neurodegenerative changes.OBJECTIVE: To study associations of dementia risk factors with retinal sensitivity, an index of retinal neural function, and retinal nerve fiber layer (RNFL) thickness, an index of retinal neural structure.METHODS: We used cross-sectional data from The Maastricht Study (up to 5,666 participants, 50.5% men, mean age 59.7), and investigated associations with regression analyses (adjusted for potential confounders).RESULTS: Most risk factors under study (i.e., hyperglycemia, unhealthy diet, lower cardiorespiratory fitness, smoking, alcohol consumption, and hypertension) were significantly associated with lower retinal sensitivity and lower RNFL thickness.CONCLUSION: Findings of this population-based study support the concept that retinal neural indices may be biomarkers for the monitoring of therapeutic strategies that aim to prevent early-stage cerebral neurodegeneration and, ultimately, dementia.

Published
2023

26. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study.

Author

van der Heide, Frank C. T., Steens, Indra L. M., Limmen, Betsie, Mokhtar, Sara, van Boxtel, Martin P. J., Schram, Miranda T., Köhler, Sebastian, Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Eussen, Simone J. P. M., Berendschot, Tos T. J. M., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Koster, Annemarie, van Sloten, Thomas T., Jansen, Jacobus F. A., Backes, Walter H., and Stehouwer, Coen D. A.

Abstract

INTRODUCTION: The retina may provide non‐invasive, scalable biomarkers for monitoring cerebral neurodegeneration. METHODS: We used cross‐sectional data from The Maastricht study (n = 3436; mean age 59.3 years; 48% men; and 21% with type 2 diabetes [the latter oversampled by design]). We evaluated associations of retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer thicknesses with cognitive performance and magnetic resonance imaging indices (global grey and white matter volume, hippocampal volume, whole brain node degree, global efficiency, clustering coefficient, and local efficiency). RESULTS: After adjustment, lower thicknesses of most inner retinal layers were significantly associated with worse cognitive performance, lower grey and white matter volume, lower hippocampal volume, and worse brain white matter network structure assessed from lower whole brain node degree, lower global efficiency, higher clustering coefficient, and higher local efficiency. DISCUSSION: The retina may provide biomarkers that are informative of cerebral neurodegenerative changes in the pathobiology of dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Thinner inner retinal layers are associated with lower cognitive performance, lower brain volume, and altered white matter network structure—The Maastricht Study

Author

van der Heide, Frank C. T., primary, Steens, Indra L. M., additional, Limmen, Betsie, additional, Mokhtar, Sara, additional, van Boxtel, Martin P. J., additional, Schram, Miranda T., additional, Köhler, Sebastian, additional, Kroon, Abraham A., additional, van der Kallen, Carla J. H., additional, Dagnelie, Pieter C., additional, van Dongen, Martien C. J. M., additional, Eussen, Simone J. P. M., additional, Berendschot, Tos T. J. M., additional, Webers, Carroll A. B., additional, van Greevenbroek, Marleen M. J., additional, Koster, Annemarie, additional, van Sloten, Thomas T., additional, Jansen, Jacobus F. A., additional, Backes, Walter H., additional, and Stehouwer, Coen D. A., additional

Published
2023
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30. Associations of Arterial Stiffness With Cognitive Performance, and the Role of Microvascular Dysfunction: The Maastricht Study

Author

Rensma, Sytze P., Stehouwer, Coen D.A., Van Boxtel, Martin P.J., Houben, Alfons J.H.M., Berendschot, Tos T.J.M., Jansen, Jaap F.A., Schalkwijk, Casper G., Verhey, Frans R.J., Kroon, Abraham A., Henry, Ronald M.A., Backes, Walter H., Dagnelie, Pieter C., van Dongen, Martin C.J.M., Eussen, Simone J.P.M., Bosma, Hans, Köhler, Sebastian, Reesink, Koen D., Schram, Miranda T., and van Sloten, Thomas T.

Published
2020
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33. The association between the food environment and adherence to healthy diet quality: the Maastricht Study

Author

Chan, Jeffrey Alexander, primary, Koster, Annemarie, additional, Eussen, Simone JPM, additional, Pinho, Maria Gabriela M, additional, Lakerveld, Jeroen, additional, Stehouwer, Coen DA, additional, Dagnelie, Pieter C, additional, van der Kallen, Carla J, additional, van Greevenbroek, Marleen MJ, additional, Wesselius, Anke, additional, and Bosma, Hans, additional

Published
2023
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34. Device-measured sitting time and musculoskeletal pain in adults with normal glucose metabolism, prediabetes and type 2 diabetes–The Maastricht Study

Author

Dzakpasu, Francis Q. S., primary, Koster, Annemarie, additional, Owen, Neville, additional, Galan, Bastiaan E. de, additional, Carver, Alison, additional, Brakenridge, Christian J., additional, Boonen, Annelies, additional, Bosma, Hans, additional, Dagnelie, Pieter C., additional, Eussen, Simone J. P. M., additional, Sethi, Parneet, additional, Stehouwer, Coen D. A., additional, Schaper, Nicolaas C., additional, and Dunstan, David W., additional

Published
2023
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35. Sex comparisons in the association of prediabetes and type 2 diabetes with cognitive function, depression and quality of life: The Maastricht Study

Author

de Ritter, Rianneke, primary, Sep, Simone J. S., additional, van der Kallen, Carla J. H., additional, van Greevenbroek, Marleen M. J., additional, Koster, Annemarie, additional, Eussen, Simone J. P. M., additional, Dagnelie, Pieter C., additional, van Boxtel, Martin, additional, Schram, Miranda T., additional, Köhler, Sebastian, additional, Martens, Jordi A. J., additional, Snobl, Lucia, additional, Vos, Rimke C., additional, Stehouwer, Coen D. A., additional, and Peters, Sanne A. E., additional

Published
2023
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36. Daily Physical Activity Patterns and Their Associations with Cardiometabolic Biomarkers: The Maastricht Study

Author

Leskinen, Tuija, Passos, Valeria Lima, Dagnelie, Pieter C. C., Savelberg, H., Galan, B.E. de, Eussen, Simone J. P. M., Stenholm, Sari, Koster, A., Leskinen, Tuija, Passos, Valeria Lima, Dagnelie, Pieter C. C., Savelberg, H., Galan, B.E. de, Eussen, Simone J. P. M., Stenholm, Sari, and Koster, A.

Abstract

Contains fulltext : 296263.pdf (Publisher’s version ) (Open Access)

Published
2023

37. Circulating and adipose tissue immune cells in tissue-specific insulin resistance in humans with overweight and obesity

Author

Trouwborst, Inez, Wouters, Kristiaan, Jocken, Johan W., Jardon, Kelly M., Gijbels, Anouk, Dagnelie, Pieter C., van Greevenbroek, Marleen M.J., van der Kallen, Carla J., Stehouwer, Coen D.A., Schalkwijk, Casper G., Richard, Nathalie, Bendik, Igor, Afman, Lydia A., Blaak, Ellen E., Goossens, Gijs H., Trouwborst, Inez, Wouters, Kristiaan, Jocken, Johan W., Jardon, Kelly M., Gijbels, Anouk, Dagnelie, Pieter C., van Greevenbroek, Marleen M.J., van der Kallen, Carla J., Stehouwer, Coen D.A., Schalkwijk, Casper G., Richard, Nathalie, Bendik, Igor, Afman, Lydia A., Blaak, Ellen E., and Goossens, Gijs H.

Abstract

Objective: A proinflammatory adipose tissue (AT) microenvironment and systemic low-grade inflammation may differentially affect tissue-specific insulin sensitivity. This study investigated the relationships of abdominal subcutaneous AT (aSAT) and circulating immune cells, aSAT gene expression, and circulating inflammatory markers with liver and skeletal muscle insulin sensitivity in people with overweight and obesity. Methods: Individuals with overweight and obesity from the PERSonalized Glucose Optimization Through Nutritional Intervention (PERSON) Study (n = 219) and the Maastricht Study (replication cohort; n = 1256) underwent a seven-point oral glucose tolerance test to assess liver and muscle insulin sensitivity, and circulating inflammatory markers were determined. In subgroups, flow cytometry was performed to identify circulating and aSAT immune cells, and aSAT gene expression was evaluated. Results: The relative abundances of circulating T cells, nonclassical monocytes, and CD56dim CD16+ natural killer cells were inversely associated with liver, but not muscle, insulin sensitivity in the PERSON Study. The inverse association between circulating (classical) monocytes and liver insulin sensitivity was confirmed in the Maastricht Study. In aSAT, immune cell populations were not related to insulin sensitivity. Furthermore, aSAT gene expression of interleukin 6 and CD14 was positively associated with muscle, but not liver, insulin sensitivity. Conclusions: The present findings demonstrate that circulating immune cell populations and inflammatory gene expression in aSAT show distinct associations with liver and muscle insulin sensitivity.

Published
2023

39. Blood pressure variability and microvascular dysfunction: the Maastricht Study

Author

Zhou, Tan Lai, Rensma, Sytze P., van der Heide, Frank C.T., Henry, Ronald M.A., Kroon, Abraham A., Houben, Alfons J.H.M., Jansen, Jacobus F.A., Backes, Walter H., Berendschot, Tos T.J.M., Schouten, Jan S.A.G., van Dongen, Martien C.J.M., Eussen, Simone J.P.M., Dagnelie, Pieter C., Webers, Carroll A.B., Schram, Miranda T., Schalkwijk, Casper G., van Sloten, Thomas T., and Stehouwer, Coen D.A.

Published
2020
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42. Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Author

Onderwater, Gerrit L.J., Ligthart, Lannie, Bot, Mariska, Demirkan, Ayse, Fu, Jingyuan, van der Kallen, Carla J.H., Vijfhuizen, Lisanne S., Pool, René, Liu, Jun, Vanmolkot, Floris H.M., Beekman, Marian, Wen, Ke-xin, Amin, Najaf, Thesing, Carisha S., Pijpers, Judith A., Kies, Dennis A., Zielman, Ronald, de Boer, Irene, van Greevenbroek, Marleen M.J., Arts, Ilja C.W., Milaneschi, Yuri, Schram, Miranda T., Dagnelie, Pieter C., Franke, Lude, Ikram, M. Arfan, Ferrari, Michel D., Goeman, Jelle J., Slagboom, P. Eline, Wijmenga, Cisca, Stehouwer, Coen D.A., Boomsma, Dorret I., van Duijn, Cornelia M., Penninx, Brenda W., ʼt Hoen, Peter A.C., Terwindt, Gisela M., and van den Maagdenberg, Arn M.J.M.

Published
2019
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43. Carotid stiffness is associated with impairment of cognitive performance in individuals with and without type 2 diabetes. The Maastricht Study

Author

Geijselaers, Stefan L.C., Sep, Simone J.S., Schram, Miranda T., van Boxtel, Martin P.J., van Sloten, Thomas T., Henry, Ronald M.A., Reesink, Koen D., Kroon, Abraham A., Koster, Annemarie, Schaper, Nicolaas C., Dagnelie, Pieter C., van der Kallen, Carla J.H., Biessels, Geert Jan, and Stehouwer, Coen D.A.

Published
2016
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44. Arterial stiffness is associated with depression in middle-aged men--the Maastricht Study

Author

Onete, Veronica, Henry, Ronald M., Sep, Simone J.S., Koster, Annemarie, van der Kallen, Carla J., Dagnelie, Pieter C., Schaper, Nicolaas, Kohler, Sebastian, Reesink, Koen, Stehouwer, Coen D.A., and Schram, Miranda T.

Subjects
Major depressive disorder -- Causes of, Middle aged men -- Psychological aspects -- Health aspects, Arteries -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Arterial stiffening may underlie the association between depression and cardiovascular disease (CVD), but reported data are inconsistent. We investigated the associations between aortic stiffness and major depressive disorder (MDD) and depressive symptoms, and whether these differed by sex and age. Methods: We measured carotid to femoral pulse wave velocity (cfPWV) using applanation tonometry, and we assessed depression using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9) in a cohort of participants from The Maastricht Study. Logistic and negative binominal models were adjusted for age, type 2 diabetes mellitus (T2DM), mean arterial pressure (MAP) and CVD risk factors. Results: We included 2757 participants in our analyses (48.8% men, mean age 59.8 [+ or -] 8.1 yr, 27% T2DM). We found that cfPWV was associated with MDD in men (fully adjusted odds ratio [OR] 2.36, 95% confidence interval [CI] 1.45-3.84), but not in women (OR 1.57, 95% CI 0.93-2.66), aged 60 years or younger. The ORs were not significant in individuals older than 60 years (men: OR 1.03, 95% CI 0.63-1.68; women: OR 0.64, 95% CI 0.32-1.31). Similarly, cfPWV was associated with a higher PHQ-9 score in men (rate ratio 1.28, 95% CI 1.09-1.52), but not in women (rate ratio 1.11,95% CI 0.99-1.23), aged 60 years or younger. Associations were not significant in individuals older than 60 years (men: rate ratio 0.96, 95% CI 0.84-1.08; women: rate ratio 1.00, 95% CI 0.90-1.12). Limitations: We cannot rule out reversed causation in this cross-sectional study. Conclusion: Greater aortic stiffness is associated with MDD and depressive symptoms among middle-aged men and to a lesser extent in women, whereas this association was not observed in old age., Introduction Arterial stiffening is considered a potential mechanism that could underlie the consistently observed association between depression and cardiovascular disease (CVD). (1-3) Arterial stiffening may cause damage to the cerebral [...]

Published
2018
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45. Reliability of HR-pQCT Derived Cortical Bone Structural Parameters When Using Uncorrected Instead of Corrected Automatically Generated Endocortical Contours in a Cross-Sectional Study: The Maastricht Study

Author

de Waard, Ellis A. C., Sarodnik, Cindy, Pennings, Alexander, de Jong, Joost J. A., Savelberg, Hans H. C. M., van Geel, Tineke A., van der Kallen, Carla J., Stehouwer, Coen D. A., Schram, Miranda T., Schaper, Nicolaas, Dagnelie, Pieter C., Geusens, Piet P. M. M., Koster, Annemarie, van Rietbergen, Bert, and van den Bergh, Joop P. W.

Published
2018
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46. Circulating and adipose tissue immune cells in tissue‐specific insulin resistance in humans with overweight and obesity

Author

Trouwborst, Inez, primary, Wouters, Kristiaan, additional, Jocken, Johan W., additional, Jardon, Kelly M., additional, Gijbels, Anouk, additional, Dagnelie, Pieter C., additional, van Greevenbroek, Marleen M. J., additional, van der Kallen, Carla J., additional, Stehouwer, Coen D. A., additional, Schalkwijk, Casper G., additional, Richard, Nathalie, additional, Bendik, Igor, additional, Afman, Lydia A., additional, Blaak, Ellen E., additional, and Goossens, Gijs H., additional

Published
2023
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47. Comment on Lee et al. Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Diabetes Care 2022;45:1917–1930

Author

Buziau, Amée M., primary, Blokland, Gabriëlla A.M., additional, Schalkwijk, Casper G., additional, Scheijen, Jean L.J.M., additional, Simons, Pomme I.H.G., additional, Eussen, Simone J.P.M., additional, Dagnelie, Pieter C., additional, van Greevenbroek, Marleen M.J., additional, Wesselius, Anke, additional, Stehouwer, Coen D.A., additional, and Brouwers, Martijn C.G.J., additional

Published
2023
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