1. Novel application of [
- Author
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Lisette, Meijer, Kinga P, Böszörményi, Jaco, Bakker, Gerrit, Koopman, Petra, Mooij, Dagmar, Verel, Zahra, Fagrouch, Babs E, Verstrepen, Uta, Funke, Martien P J, Mooijer, Jan A M, Langermans, Ernst J, Verschoor, Albert D, Windhorst, and Marieke A, Stammes
- Subjects
Pyrimidines ,SARS-CoV-2 ,Positron Emission Tomography Computed Tomography ,Animals ,COVID-19 ,Pyrazoles ,Pneumonia ,Lung ,Macaca mulatta - Abstract
The aim of this study was to investigate the application of [Four experimentally SARS-CoV-2 infected rhesus monkeys were followed for seven weeks post infection (pi) with a weekly PET-CT using [All animals were positive for SARS-CoV-2 in both the swabs and BALs on multiple timepoints pi. The initial development of pulmonary lesions was already detected at the first scan, performed 2-days pi. PET revealed an increased tracer uptake in the pulmonary lesions and mediastinal lymph nodes of all animals from the first scan obtained after infection and onwards. However, also an increased uptake was detected in the lung tissue surrounding the lesions, which persisted until day 30 and then subsided by day 37-44 pi. In parallel, a similar pattern of increased expression of activation markers was observed on dendritic cells in blood.This study illustrates that [
- Published
- 2022