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11 results on '"Daddario, Pedro"'

1. Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture

Author

Abercrombie, Cameron, primary, Ashcroft, Christopher P., additional, Badland, Matthew, additional, Baldwin, Aaron, additional, Baldwin, Livia T., additional, Brisley, Sarah, additional, Callar, Wayne, additional, Daddario, Pedro, additional, Hilou, Elaa, additional, James, Chintelle, additional, Li, Ruizhi, additional, Liu, Yiyang, additional, Monfette, Sebastien, additional, Piper, Jared L., additional, Reyes, Giselle, additional, Risley, Hud, additional, Salingue, Fabrice H., additional, Saunyama, Kudzai, additional, and Vetelino, Michael G., additional

Published
2023
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2. Osmium ester-hinged chlorin dimers

Author

Chaudhri, Nivedita, primary, Dorazio, Sarina J., additional, Samankumara, Lalith P., additional, Daddario, Pedro, additional, Head, Michelle L., additional, Zeller, Matthias, additional, and Bruckner, Christian, additional

Published
2023
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3. Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Author

Goetz, Adam E., primary, Becirovic, Husein, additional, Blasberg, Florian, additional, Chen, Bo, additional, Clarke, Hugh J., additional, Colombo, Matteo, additional, Daddario, Pedro, additional, Damon, David B., additional, Depretz, Christelle, additional, Dumond, Yves R., additional, Grilli, Maria D., additional, Han, Lu, additional, Houck, Tim L., additional, Johnson, Amber M., additional, Jones, Kris N., additional, Jung, Jörg, additional, Leeman, Michel, additional, Liu, Fangfang, additional, Lu, Cuong V., additional, Mangual, Emilio J., additional, Nelson, Jade D., additional, Puchlopek-Dermenci, Angela L. A., additional, Ruggeri, Sally Gut, additional, Simonds, Paul A., additional, Sitter, Barbara, additional, Virtue, Daniel E., additional, Wang, Shuguang, additional, Yu, Lixin, additional, and Yu, Tao, additional

Published
2021
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4. Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block..

Author

Goetz, Adam E., Becirovic, Husein, Blasberg, Florian, Bo Chen, Clarke, Hugh J., Colombo, Matteo, Daddario, Pedro, Damon, David B., Depretz, Christelle, Dumond, Yves R., Grilli, Maria D., Lu Han, Houck, Tim L., Johnson, Amber M., Jones, Kris N., Jörg Jung, Leeman, Michel, Fangfang Liu, Lu, Cuong V., and Mangual, Emilio J.

Published
2022
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7. Helimeric Porphyrinoids: Stereostructure and Chiral Resolution of meso-Tetraarylmorpholinochlorins

Author

Brückner, Christian, Götz, Daniel C. G., Fox, Simon P., Ryppa, Claudia, McCarthy, Jason R., Bruhn, Torsten, Akhigbe, Joshua, Banerjee, Subhadeep, Daddario, Pedro, Daniell, Heather W., Zeller, Matthias, Boyle, Ross W., and Bringmann, Gerhard

Abstract

The synthesis and chiral resolution of free-base and Ni(II) complexes of a number of derivatives of meso-tetraphenylmorpholinochlorins, with and without direct β-carbon-to-o-phenyl linkages to the flanking phenyl groups, is described. The morpholinochlorins, a class of stable chlorin analogues, were synthesized in two to three steps from meso-tetraphenylporphyrin. The conformations and the relative stereostructures of a variety of free-base and Ni(II) complexes of these morpholinochlorins were elucidated by X-ray diffractometry. Steric and stereoelectronic arguments explain the relative stereoarray of the morpholino-substituents, which differ in the free-base and Ni(II) complexes, and in the monoalkoxy, β-carbon-to-o-phenyl linked morpholinochlorins, and the dialkoxy derivatives. The Ni(II) complexes were all found to be severely ruffled whereas the free-base chromophores are more planar. As a result of the helimeric distortion of their porphyrinoid chromophores, the ruffled macrocycles possess a stable inherent element of chirality. Most significantly, resolution of the racemic mixtures was achieved, both by classical methods via diastereomers and by HPLC on a chiral phase. Full CD spectra were recorded and modeled using quantum-chemical computational methods, permitting, for the first time, an assignment of the absolute configurations of the chromophores. The report expands the range of known pyrrole-modified porphyrins. Beyond this, it introduces large chiral porphyrinoid π-systems that exist in the form of two enantiomeric, stereochemically stable helimers that can be resolved. This forms the basis for possible future applications, for example, in molecular-recognition systems or in materials with chiroptic properties.

Published
2024
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9. meso-Arylporpholactones and their Reduction Products

Author

Brückner, Christian, primary, Ogikubo, Junichi, additional, McCarthy, Jason R., additional, Akhigbe, Joshua, additional, Hyland, Michael A., additional, Daddario, Pedro, additional, Worlinsky, Jill L., additional, Zeller, Matthias, additional, Engle, James T., additional, Ziegler, Christopher J., additional, Ranaghan, Matthew J., additional, Sandberg, Megan N., additional, and Birge, Robert R., additional

Published
2012
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10. Helimeric Porphyrinoids: Stereostructure and Chiral Resolution of meso-Tetraarylmorpholinochlorins

Author

Brückner, Christian, primary, Götz, Daniel C. G., additional, Fox, Simon P., additional, Ryppa, Claudia, additional, McCarthy, Jason R., additional, Bruhn, Torsten, additional, Akhigbe, Joshua, additional, Banerjee, Subhadeep, additional, Daddario, Pedro, additional, Daniell, Heather W., additional, Zeller, Matthias, additional, Boyle, Ross W., additional, and Bringmann, Gerhard, additional

Published
2011
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11. meso-Tetraarylporpholactones as high pH sensors

Author

Khalil, Gamal E., primary, Daddario, Pedro, additional, Lau, Kimberly S. F., additional, Imtiaz, Sayed, additional, King, Michelle, additional, Gouterman, Martin, additional, Sidelev, Alexey, additional, Puran, Narissa, additional, Ghandehari, Masoud, additional, and Brückner, Christian, additional

Published
2010
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