869 results on '"Dabrowski, J."'
Search Results
2. Predictors of COVID-19 Hospital Treatment Outcome
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Tomasiuk R, Dabrowski J, Smykiewicz J, and Wiacek M
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covid-19 ,biological markers ,c-reactive protein ,procalcitonin ,fibrinogen ,d-dimers ,immature granulocytes ,interleukin-6 ,Medicine (General) ,R5-920 - Abstract
Ryszard Tomasiuk,1 Jan Dabrowski,2 Jolanta Smykiewicz,3 Magdalena Wiacek4 1Department of Medicine, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, Poland; 2Department of Pharmacology, National Medicines Institute, Warsaw, Poland; 3Central Medical Diagnostic Laboratory, Dr. Tytus Chałubiński Specialist Hospital in Radom, Radom, Poland; 4Department of Physiotherapy, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, PolandCorrespondence: Ryszard TomasiukDepartment of Medicine, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, PolandEmail r.tomasiuk@wp.plBackground: There are more than 228,394,572 confirmed cases and 4,690,186 confirmed deaths caused by COVID-19 worldwide. The magnitude of the COOVID-19 pandemic has stimulated research on the treatment and diagnosis of COVID-19 patients.Objective: In this report, a battery of specific parameters was used to develop a model that allows prediction of the outcome of the COVID-19 treatment. These parameters are C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6.Methods: The study was carried out on a sample of N = 49 survivors (22 men, 27 women) and 83 deceased patients (62 men, 21 women). The distribution of means and differences in means of the parameters studied between survivors and deceased patients were evaluated using the bootstrap method.Results: A mathematical model that allows for the prediction of hospitalization outcome was obtained using the Naive Bayes model. The results demonstrated a statistically significant difference between survivors and deceased patients in all parameters studied. A mathematical model employing a battery of parameters provided a 97% precision in predicting the outcome of hospitalization.Conclusion: This study showed that the cross-correlation of survivability with absolute levels of C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6 could be used successfully in the hospital setting as a diagnostic tool.Keywords: Covid-19, biological markers, C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, interleukin-6
- Published
- 2021
3. Plasma-enhanced chemical vapor deposition of amorphous Si on graphene
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Lupina, G., Strobel, C., Dabrowski, J., Lippert, G., Kitzmann, J., Krause, H. M., Wenger, Ch., Lukosius, M., Wolff, A., Albert, M., and Bartha, J. W.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Plasma-enhanced chemical vapor deposition of thin a-Si:H layers on transferred large area graphene is investigated. Radio frequency (RF, 13.56 MHz) and very high frequency (VHF, 140 MHz) plasma processes are compared. Both methods provide conformal coating of graphene with Si layers as thin as 20 nm without any additional seed layer. The RF plasma process results in amorphization of the graphene layer. In contrast, the VHF process keeps the high crystalline quality of the graphene layer almost intact. Correlation analysis of Raman 2D and G band positions indicates that Si deposition induces reduction of the initial doping in graphene and an increase of compressive strain. Upon rapid thermal annealing the amorphous Si layer undergoes dehydrogenation and transformation into a polycrystalline film whereby a high crystalline quality of graphene is preserved., Comment: 9 pages, 6 figures
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- 2016
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4. Direct growth of low-doped graphene on Ge/Si(001) surfaces
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Dabrowski, J., Lippert, G., Avila, J., Baringhaus, J., Colambo, I., Dedkov, Yu. S., Herziger, F., Lupina, G., Maultzsch, J., Schaffus, T., Schroeder, T., Sowinska, M., Tegenkamp, C., Vignaud, D., and Asensio, M. -C.
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Condensed Matter - Materials Science - Abstract
The practical difficulties to use graphene in microelectronics and optoelectronics is that the available methods to grow graphene are not easily integrated in the mainstream technologies. A growth method that could overcome at least some of these problems is chemical vapour deposition (CVD) of graphene directly on semiconducting (Si or Ge) substrates. Here we report on the comparison of the CVD and molecular beam epitaxy (MBE) growth of graphene on the technologically relevant Ge(001)/Si(001) substrate from ethene (C$_2$H$_4$) precursor and describe the physical properties of the films as well as we discuss the surface reaction and diffusion processes that may be responsible for the observed behavior. Using nano angle resolved photoemission (nanoARPES) complemented by transport studies and Raman spectroscopy, we report the direct observation of massless Dirac particles in monolayer graphene, providing a comprehensive mapping of their low-hole doped Dirac electron bands. The micrometric graphene flakes are oriented along two predominant directions rotated by $30^\circ$ with respect to each other. The growth mode is attributed to the mechanism when small graphene "molecules" nucleate on the Ge(001) surface and it is found that hydrogen plays a significant role in this process., Comment: text and 8 figures
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- 2016
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5. A 12-month follow-up study evaluating group interventions for children with Tourette Syndrome
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Dabrowski, J. M.
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618.92 - Abstract
This thesis consists of three parts: a systematic literature review, an empirical paper and a critical appraisal. It aims to contribute to the evidence base for psychological interventions for Tourette Syndrome (TS). TS is a neurodevelopmental condition characterised by the presence of both motor and vocal tics. Tics typically first present in childhood and are associated with psychiatric co-morbidity, social and emotional difficulties, impaired school functioning and a diminished quality of life. The literature review explores the efficacy and effectiveness of currently available psychological interventions for TS. It reviews both traditional behavioural approaches as well as newer adaptations of existing treatment protocols. The empirical paper evaluates the long-term outcomes of two group treatments (Comprehensive Behavioural Intervention for Tics and psychoeducation) for children with TS. It assesses the effect of these treatments on tic severity, neuropsychological functioning, quality of life and school attendance. Finally, the critical appraisal reflects on the process of conducting the research study. Specifically, it comments on the unique advantages and disadvantages of joining a larger research project, further explores the strengths and limitations of the study’s methodology and finally reflects on the experience of working with children with a neurodevelopmental disorder.
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- 2016
6. Processing and integration of graphene in a 200 mm wafer Si technology environment
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Lisker, M., Lukosius, M., Fraschke, M., Kitzmann, J., Dabrowski, J., Fursenko, O., Kulse, P., Schulz, K., Krüger, A., Drews, J., Schulze, S., Wolansky, D., Schubert, A.M., Katzer, J., Stolarek, D., Costina, I., Wolff, A., Dziallas, G., Coccetti, F., and Mai, A.
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- 2019
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7. The optical model potential of the $\Sigma$ hyperon in nuclear matter
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Dabrowski, J. and Rozynek, J.
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Nuclear Theory - Abstract
We present our attempts to determine the optical model potential $U_\Sigma = V_\Sigma -iW_\Sigma$ of the $\Sigma$ hyperon in nuclear matter. We analyze the following sources of information on $U_\Sigma$: $\Sigma N$ scattering, $\Sigma^-$ atoms, and final state interaction of $\Sigma$ hyperons in the $(\pi,K^+)$ and $(K^-.\pi)$ reactions on nuclear targets. We conclude that $V_\Sigma$ is repulsive inside the nucleus and has a shallow a tractive pocket at the nuclear surface. These features of $V_\Sigma$ are consistent with the Nijmegen model F of the hyperon-nucleon interaction., Comment: Presented at the XXXI Mazurian Lakes Conference on Physics, Piaski, Poland, August 30-September. 5, 2009}
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- 2009
8. Vertical graphene base transistor
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Mehr, W, Dabrowski, J, Scheytt, JC, Lippert, G, Xie, YH, Lemme, MC, Ostling, M, and Lupina, G
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cond-mat.mes-hall ,cond-mat.mtrl-sci ,Applied Physics ,Electrical and Electronic Engineering - Abstract
We present a novel graphene-based-device concept for a high-frequency operation: a hot-electron graphene base transistor (GBT). Simulations show that GBTs have high current on/off ratios and high current gain. Simulations and small-signal models indicate that it potentially allows terahertz operation. Based on energy-band considerations, we propose a specific material solution that is compatible with SiGe process lines. © 2012 IEEE.
- Published
- 2012
9. Ab initio calculations and rate equation simulations for vacancy and vacancy-oxygen clustering in silicon
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Kissinger, G., Dabrowski, J., Sinno, T., Yang, Y., Kot, D., and Sattler, A.
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- 2017
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10. Effect of triiodothyronine ([T.sub.3]) excess on fatty acid metabolism in the soleus muscle from endurance-trained rats
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Gorecka, M., Synak, M., Brzezinska, Z., Dabrowski, J., and Zernicka, E.
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Skeletal muscle -- Health aspects ,Triiodothyronine -- Dosage and administration ,Fatty acid metabolism -- Health aspects ,Biological sciences - Abstract
Abstract: We studied whether short-term administration of triiodothyronine ([T.sub.3]) for the last 3 days of endurance training would influence the rate of uptake of palmitic acid (PA) as well as [...]
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- 2016
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11. High-K Dielectrics: The Example of Pr2O3
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Osten, H. J., Dąbrowski, J., Müssig, H.-J., Fissel, A., Zavodinsky, V., Hull, Robert, editor, Osgood, R. M., Jr., editor, Parisi, Jürgen, editor, Warlimont, Hans, editor, Dabrowski, Jarek, editor, and Weber, Eicke R., editor
- Published
- 2004
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12. Transistors and Atoms
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Dąbrowski, J., Weber, E. R., Müssig, H.-J., Schröter, W., Hull, Robert, editor, Osgood, R. M., Jr., editor, Parisi, Jürgen, editor, Warlimont, Hans, editor, Dabrowski, Jarek, editor, and Weber, Eicke R., editor
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- 2004
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13. Basic science and challenges in process simulation
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Dąbrowski, J., Müssig, H.-J., Duane, M., Dunham, S.T., Goossens, R., Vuong, H.-H., and Kramer, Bernhard, editor
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- 1999
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14. Ab Initio Simulations for Microelectronics: $ZnGa_2O_4$ and Hexagonal BN
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Dabrowski, J., Reichmann, F., Franck, M., and Lukosius, M.
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- 2022
15. Σ Hypernuclear States
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Dąbrowski, J., Rożynek, J., Mitter, H., editor, Plessas, W., editor, Adam, J., editor, Dobeš, J., editor, Mach, R., editor, Sotona, M., editor, and Dolejší, J., editor
- Published
- 1996
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16. Ge(001) surface reconstruction with Sn impurities
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Noatschk, K., primary, Hofmann, E.V.S., additional, Dabrowski, J., additional, Curson, N.J., additional, Schroeder, T., additional, Klesse, W.M., additional, and Seibold, G., additional
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- 2021
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17. Measuring Mechanical Properties of Fillet Arc T-Welded Aluminum Alloy AA7xxx Extrusions Using Digital Image Correlation
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Bruhis, M., primary, Dabrowski, J., additional, and Kish, J. R., additional
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- 2015
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18. On Narrow Σ Hypernuclear States with Positive Energy
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Dabrowski, J., Fantoni, S., editor, and Rosati, S., editor
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- 1991
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19. Hf- and Zr-based alkaline earth perovskite dielectrics for memory applications
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Łupina, G., Seifarth, O., Kozłowski, G., Dudek, P., Dąbrowski, J., Lippert, G., and Müssig, H.-J.
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- 2009
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20. Investigation of atomic vapour deposited TiN/HfO 2/SiO 2 gate stacks for MOSFET devices
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Wenger, Ch., Lukosius, M., Costina, I., Sorge, R., Dabrowski, J., Müssig, H.-J., Pasko, S., and Lohe, Ch.
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- 2008
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21. On-chip stimulus generator for gain, linearity, and blocking profile test of wideband RF front ends
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Ramzan, R., Ahsan, N., and Dabrowski, J.
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Embedded system ,System on a chip ,Complementary metal oxide semiconductors -- Analysis ,Voltage -- Measurement ,Embedded systems -- Design and construction ,Embedded systems -- Testing ,Oscillators (Electronics) -- Design and construction - Published
- 2010
22. Atomic - vapour - deposited HfO 2 and Sr 4Ta 2O 9 layers for metal-insulator-metal applications
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Lukosius, M., Wenger, Ch., Schroeder, T., Dabrowski, J., Sorge, R., Costina, I., Müssig, H.-J., Pasko, S., and Lohe, Ch.
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- 2007
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23. The effect of ion implantation on the wear of Co–Cr–Mo alloy
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Werner, Z., Barlak, M., Grądzka-Dahlke, M., Diduszko, R., Szymczyk, W., Dąbrowski, J., Piekoszewski, J., and Borkowska, K.
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- 2007
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24. Heteroepitaxial praseodymium sesquioxide films on Si(1 1 1): A new model catalyst system for praseodymium oxide based catalysts
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Schaefer, A., Schroeder, T., Lupina, G., Borchert, Y., Dabrowski, J., Wenger, Ch., and Bäumer, M.
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- 2007
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25. Σatomic states and the nucleon distribution in Pb
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Dabrowski, J. and Rożynek, J.
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- 2005
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26. Corrosion testing of sintered samples made of the Co-Cr-Mo alloy for surgical applications
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Krasicka-Cydzik, E., Oksiuta, Z., and Dabrowski, J. R.
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- 2005
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27. On the epitaxy of twin-free cubic (111) praseodymium sesquioxide films on Si(111)
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Schroeder, T., Zaumsell, P., Weidner, G., Wenger, Ch., Dabrowski, J., Mussig, H.-J., and Storck, P.
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Praseodymium -- Atomic properties ,Dielectric films -- Atomic properties ,Thin films -- Atomic properties ,Epitaxy -- Research ,Ferroelectric crystals -- Research ,Physics - Abstract
Twin-free epitaxial cubic (111) praseodymium sesquioxide films were prepared on Si(111) by hexagonal-to-cubic phase transition and synchrotron radiation grazing incidence X-ray diffraction and transmission electron microscopy were applied to characterize the phase transition and the film structure. Transmission electron microscopy shows that the phase transition is accompanied by an interface reaction at the oxide/Si(111) boundary.
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- 2006
28. Crystal structure of 3-(3-oxo-3-naphthyl-propenylamino)-1-naphthyIprop- 2-en-l-one, C26H19NO2 and of 1-{(4,4-dimethyl)3-oxopent-1-enylamino}-4,4-dimethyl-pent-1-en-3-one, C14H23NO2, two bisacylvinylamines with bifurcated hydrogen bonding
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Imgartinger H., Oeser Τ., and Dabrowski J.
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Physics ,QC1-999 ,Crystallography ,QD901-999 - Published
- 2001
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29. Effect of Corrosion on the Strength of Fillet Arc Welded Cu-Lean AA7xxx Joints
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Dabrowski, J., primary, Bruhis, M., additional, and Kish, J.R., additional
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- 2012
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30. Σ- atoms and the ΣN interaction
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Dabrowski, J., Rożynek, J., and Anagnostatos, G.S.
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- 2002
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31. Runoff-Related Pesticide Input into the Lourens River, South Africa: Basic Data for Exposure Assessment and Risk Mitigation at the Catchment Scale
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Dabrowski, J. M., Peall, S. K. C., Reinecke, A. J., Liess, M., and Schulz, R.
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- 2002
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32. Atomically Smooth Ultrathin Oxide Layers on SI(113)
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Müssig, H. J., Dabrowski, J., and Hinrich, S.
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- 1999
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33. Fluorine incorporation into gate stacks of advanced silicon memory technologies: simulation, depth distribution and reliability
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Kruger, D., Dabrowski, J., Gaworzewski, P., and Kurps, R.
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Electronic equipment and supplies -- Research ,Fluorine -- Research ,Physics - Abstract
Research on fluorine segregation is examined in detail. Segregation and diffusion kinetics are analyzed, and the significance of the results is assessed.
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- 2001
34. Observational and Modeling Evidence of Seasonal Trends in Sediment‐Derived Material Inputs to the Chukchi Sea
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Kipp, L. E., primary, Spall, M. A., additional, Pickart, R. S., additional, Kadko, D. C., additional, Moore, W. S., additional, Dabrowski, J. S., additional, and Charette, M. A., additional
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- 2020
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35. Structure of Magnetically Ordered Si:Mn
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Bak-Misiuk, Jadwiga, primary, Dynowska, E., additional, Romanowski, P., additional, Shalimov, A., additional, Misiuk, Andrzej, additional, Kret, S., additional, Dluzewski, P., additional, Domagala, J., additional, Caliebe, Wolfgang, additional, Dabrowski, J., additional, and Prujszczyk, M., additional
- Published
- 2007
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36. Two Paths of Oxide Precipitate Nucleation in Silicon
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Kissinger, G., primary, Dabrowski, J., additional, Sattler, Andreas, additional, Müller, Timo, additional, and von Ammon, Wilfried, additional
- Published
- 2007
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37. MIM capacitors using amorphous high-k PrTixOy dielectrics
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Wenger, Ch., Sorge, R., Schroeder, T., Mane, A.U., Lippert, G., Lupina, G., Dąbrowski, J., Zaumseil, P., and Muessig, H.-J.
- Published
- 2005
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38. Process integration of Pr-based high- k gate dielectrics
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Mane, A.U., Wenger, Ch., Lupina, G., Schroeder, T., Lippert, G., Sorge, R., Zaumseil, P., Weidner, G., Dabrowski, J., and Müssig, H.-J.
- Published
- 2005
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39. Σ-hypernuclear states created in (K−, π) reactions
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Dabrowski, J. and Rozynek, J.
- Published
- 1997
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40. Growth of ScN(111) on Sc2O3(111) for GaN integration on Si(111): Experiment and ab-initio calculations.
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Sana, P., Tetzner, H., Dabrowski, J., Lupina, L., Costina, I., Thapa, S. B., Storck, P., Schroeder, T., and Zoellner, M. H.
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THIOCYANATES ,PHOTOELECTRON spectroscopy ,MOLECULAR beam epitaxy ,EPITAXY ,ELECTRIC fields - Abstract
Growth mechanism of ScN on Sc
2 O3 for integration of Ga-polar GaN on Si(111) is investigated by in-situ X-ray photoemission spectroscopy, ex-situ time-of-flight secondary ion mass spectrometry, atomic force microscopy, and ab-initio density functional theory (DFT) calculations. The ScN films are grown by molecular beam epitaxy from e-beam evaporated Sc and N plasma. The films grow in a layer-by-layer (Frank-van der Merwe, FM) fashion. Diffusion of nitrogen into Sc2 O3 and segregation of oxygen onto ScN are observed. The segregated O atoms are gradually removed from the surface by N atoms from the plasma. Experiment and theory show that nitrogen cannot be efficiently incorporated into Sc2 O3 by exposing it to N plasma alone, and calculations indicate that anion intermixing between ScN and Sc2 O3 should be weak. On the basis of ab-initio data, the indiffusion of N into Sc2 O3 is attributed mostly to the effect of interaction between ScN ad-dimers on the Sc2 O3 surface in the initial stage of growth. The segregation of O to the ScN surface is understood as driven by the tendency to compensate build-up of the electric field in the polar ScN film. This segregation is computed to be energetically favorable (by 0.4 eV per O atom) already for a monolayer of ScN; the energy gain increases to 1.0 eV and 1.6 eV per O atom for two and three ScN layers, respectively. Finally, it is verified by DFT that the ScN deposition method in which Sc metallic film is deposited first and then nitridized would lead to strong incorporation of O into the grown film, accompanied by strong reduction of the Sc2 O3 substrate. [ABSTRACT FROM AUTHOR]- Published
- 2016
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41. Fundamental Concepts and Methods
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Dabrowski, J., primary and Müssig, H.-J., additional
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- 2000
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42. Adsorption on Silicon Surfaces
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Dabrowski, J., primary
- Published
- 2000
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43. Evolution of Clean Si(001)
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Dabrowski, J., primary
- Published
- 2000
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44. Geometries of Clean Si(001)
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Dabrowski, J., primary
- Published
- 2000
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45. The Famous Reconstruction of Si(001)
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Dabrowski, J., primary
- Published
- 2000
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46. Afterword
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Dabrowski, J., primary
- Published
- 2000
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47. On the Road to Devices: SiO2/Si(001)
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Dabrowski, J., primary and Müssig, H.-J., additional
- Published
- 2000
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48. First investigation of metal–insulator–metal (MIM) capacitor using Pr 2O 3 dielectrics
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Wenger, Ch., Dąbrowski, J., Zaumseil, P., Sorge, R., Formanek, P., Lippert, G., and Müssig, H.-J.
- Published
- 2004
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49. RUNOFF,RELATED PESTICIDE INPUT INTO THE LOURENS RIVER, SOUTH AFRICA: BASIC DATA FOR EXPOSURE ASSESSMENT AND RISK MITIGATION AT THE CATCHMENT SCALE
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Dabrowski, J. M., Peall, S. K. C., Reinecke, A. J., Liess, M., and Schulz, R.
- Published
- 2002
50. Liraglutide and Renal Outcomes in Type 2 Diabetes
- Author
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Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB, LEADER Steering Committee and Investigators. Bergenstal R, Daniels G, Moses AC, Nauck M, Nissen S, Pocock S, Steinberg W, Stockner M, Kristensen P, Ravn LS, Zychma M, Flyvbjerg A, Ford I, Kloos RT, Schactman MJ, Sleight P, Swedberg K, Tenner SM, Akalın S, Arechavaleta R, Bain S, Babkowski MC, Benroubi M, Berard L, Comlekci A, Czupryniak L, Eliasson B, Eriksson M, Fonseca V, Franek E, Gross J, Hafidh K, Haluzik M, Hayes F, Huang YY, Jacob S, Kaddaha G, Khalil A, Kilhovd B, Laakso M, Leiter L, Lalic N, Ji L, Luedemann J, Mannucci E, Marre M, Masmiquel L, Mota M, Omar M, O’Shea D, Pan C, Petrie J, Pieber T, Pratley R, Raz I, Rea R, Rutten G, Satman I, Shestakova M, Simpson R, Smith D, Tack C, Tarnow L, Thomas N, Van Gaal L, Travert F, Vidal J, Warren M, Yoon KH, Tuttle RM, Sheerman SI, Hegedüs L, Baerwald H, Bergenstal M, Celik S, Dias C, Eder M, Fitzgibbons S, Irvhage L, Kloluckova J, Kriulianski R, McDuffie R, Moen S, Paster A, Saalfeld RM, Sankar K, Shehaj E, Swierzewska P, Tiktin M, Tovey S, Gibson CM, Chakrabarti AK, Dashe JF, Hinchey J, Leary MC, Pride Y, Wiviott S, Allen S, Mehr AP, Mutter WP, Parikh S, Ray S, Cheifetz A, Leffler D, Sheth S, Alexander E, Gaglia JL, Goessling W, Mitzner LD, Rosenberg C, Snow KJ, Wagner A, Piazza G, Abell S, Davis T, D'Emden M, Ding SA, Gilfillan C, Greenaway T, Gunawan F, Ho J, Jackson R, Kalra B, Lau SL, Lin J, MacIsaac R, Makepeace A, Malabu U, Marjason J, McCallum R, McLean M, Moin N, Petersons C, Price S, Roberts A, Roberts D, Sangla K, Stranks S, Tan Y, Thynne T, Walters J, Ward G, Wen W, Zhang J, Brix J, Feder A, Höbaus C, Höllerl F, Höller V, Kotter T, Kratz E, Krzizek EC, Leb-Stoeger U, Mader J, Mras N, Novak E, Obendorf F, Peric S, Pesau G, Prager R, Ribitsch A, Schnack C, Schernthaner G, Wascher T, Batens AH, Benhalima K, De Block C, Ernest P, Fouckova A, Jandrain B, Lapauw B, Letiexhe M, Mathieu C, Neven S, Peiffer F, Ruige J, Scheen A, Taes Y, Van Boxelaer I, Vandistel G, Van Durme Y, Verhaegen A, Alencar E, Alencar R, Almeida AC, Alves B, Alves E, Alves G, Alves J, Araujo L, Arruda V, Augusto GA, Baggentoss R, Balestrassi L, Barbosa M, Barcelos I, Belem L, de Bem A, Betti RT, Bona R, Bosco A, Branda J, Bronstein M, Bueno T, Bulcão T, Caiado F, Camazzola F, Cambréa MF, Campos S, Canani L, Carra MK, Caruso S, Carvalho N, Casillo A, Castro D, Cavalcanti T, Cavichioli V, Cercato C, Chacra A, Challela W, Charchar HS, Chaves C, Chrisman C, Correia-Deur J, da Costa A Jr, Costa M, Costi B, Coutinho P, Coutinho W, Cunha MR, Daher J Jr, Davini E, Democh D Jr, Eliaschewitz F, Esmanhoto Facin G, Farias F, Felício J, Fernandes V, Filho CS, Filho FF, Filho M, Fontan D, Fontenele AP, Forti A, Franco D, Freire K, Fusaro A, Genestreti P, Gerchman F, Godi A, Gomes KF, Gonçalves P, Gonçalves R, Griz L, Grossman M, Gurgel MH, Vasconcellos Haddad AW, Halpern A, Hissa M, Inuy A, Jaime J, Jonasson T, Jorge JC, Malucelli FJ, Kohara S, Kramer C, Lacerda C, Ladeira S, Lana J, Lastebasse F, Leitão A, Leite S, Lerário AC, Lima D, Lima M, Lippi V, Lunardi M, Machado 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E, Martinez G, Martinez-Miss S, Marx P, Massara L, Mastoor M, Matfin G, Maturu A, Maurides P, May M, Mayfield R, Maynard B, Mazza A, McCann K, McCoy J, McCoy T, McCullen MK, McDaniel C, McDaniel AM, McDermott M, McDonald A, McMasters B, McMurray C, Medlin T, Meinel M, Mendez I, Menefee J, Meredith M, Merriweather M, Mersey J, Messino C, Meyer S, Meyers L, Michael D, Midyett C, Miklius A, Milford E, Miller B, Miller H, Milligan M, Minor A, Miranda-Palma B, Mirarchi N, Mittadodla S, Mittle J, Moffat A, Mohaupt S, Mohiuddin K, Mokshagundam S, Monaco S, Monsaert R, Montano-Pereira C, Montgomery A, Moody K, Moon M, Moore D, Moore L, Morawski E, Moreau C, Morin D, Moscoa C, Motzkin C, Mueller R, Munoz C, Munoz M, Myneni A, Naderi B, Nagireddy P, Naidu J, Naidu R, Naik S, Naimark R, Nardicchi M, Ndukwu I, Neller C, Netten-Foster L, Neumiller J, New T, Newman S, Newton T, Nguyen B, Nicol B, Nicol P, Ninivaggi L, Niswender K, Norman L, Noworatzky G, Nyenwe E, O'Brien H, O'Connell T, Oden W, Odugbesan A, Oliver M, Oliver T, Olmeda C, O'Neil C, Oremus R, Ortega T, Ortiz-Santos S, Osborn T, Padmanabhan S, Papacostea O, Park I, Parker A, Parker K, Parker R, Patel C, Patel M, Patel R, Patino M, Patterson S, Paulson K, Paz A, Pemba R, Pepe C, Perez J, Perez T, Perry D, Phillips B, Phillips J, Pickett A, Pinson M, Pitzer R, Poduri M, Poehls J, Poteat T, Powell L, Prasad S, Prevost J, Price E, Priest D, Prieto L, Purewal T, Purighalla R, Purighalla U, Quadrel M, Qureshi A, Radhamma R, Rafla E, Rajab H, Ramalingam R, Ramirez A, Ramirez J, Ramirez K, Ramirez M, Randall M, Rangaraj U, Rao V, Rasmussen P, Rasouli N, Ray A, Reed J, Rems L, Renaud K, Reno M, Resnick M, Reusch J, Reynolds L, Rhoton K, Rhudy J, Ricci C, Rice L, Richardson A, Richardson L, Rickard H, Rickels M, Riff D, Rightenour N, Risser J, Rizvi A, Robertson J, Robinson A, Robinson R, Rockwell M, Rodriguez JP, Rodriguez M, Rojas M, Rojas W, Rooker-Morris L, Root C, Rose M, Rosenberg R, Rosenstock J, Roth M, Ruby R, Sachson R, Sack P, Sadler RK, Sahai S, Salazar J, Salgam M, Samal A, Samson A, Sanagorski R, Sanchez A, Sandberg J, Sanderson M, Sandoval J, Santiago E, Sapp T, Saunders J, Schill J, Schott C, Schreiman R, Schu D, Schuh K, Schutta M, Schwartz J, Schweppe L, Scofield H, Scribner A, Seal J, Sealock J, Seaton B, Sedlak-Hanslik T, Seekins K, Segal M, Seggelke S, Semenza S, Sentman P, Serra M, Seshadri P, Sevilla E, Shah S, Shaheen K, Shanik M, Shaw J, Sheets M, Shellabarger C, Sher J, Shippey J, Shivaswamy V, Shomali M, Shore D, Shroff P, Siddiqui T, Siegwald A, Silver R, Simmons D, Simons R, Sinan A, Singh M, Sirinvaravong S, Skero J, Slover-Zipf J, Small S, Smith B, Smith K, Smith M, Sohl J, Solarz SH, Soler D, Sood A, Sora N, Souchet A, Soule J, Sparks J, Spector L, Speicher R, Spillers L, Spivey T, Springer N, Sprouse H, St John J, Stacey A, Stacey H, Stafford M, Stagner E, Staples K, Steadman E, Steed R, Steeves G, Steinberg H, Stell C, Stirman E, Straub K, Strock E, Sue M, Suris O, Sutton T, Tabbah I, Talsania M, Tang R, Tapia J, Taylor K, Taylor-Hancher R, Teator R, Tekateka M, Temple B, Temple K, Teodori M, Tharp P, Thethi T, Theuma P, Thomas S, Thottan A, Thrasher J, Thrasher L, Tiemeyer M, Tinney I, Tobin T, Toma S, Tovar M, Townsend J, Trantow C, Traylor H, Trevino M, Troy M, Trumper D, Tryggestad J, Tucker C, Turner J, Turney R, Tuten C, Tyzack J, Ullo L, Underkofler C, Unger J, Urdanetta R, Valdivia V, Valenti S, Vanderheiden A, Vanderlinde-Wood M, Varma C, Vasquez E, Vazquez M, Vickery D, Villafuerte B, Villegas C, Vivar J, Vivekananthan K, Vo G, Vukojicic K, Wachter A, Wahl D, Waitmann J, Walker D, Walsh J, Walsh K, Walton A, Wang A, Wardell K, Watkins S, Watkinson J, Watts M, Watwe V, Weaver N, Weber R, Wedick C, Weeks D, Weeks L, Weindorff K, Weinstein R, Weiss S, Wenger K, Wentworth M, Werner A, West M, Whelan S, White B, White J, Whitmire M, Whittington R, Wical J, Wigley C, Wilkins F, Will K, Williams A, Wilson LE, Wince M, Wine S, Winkle P, Winner C, Wise J, Witte M, Wittenmyer J, Wood C, Wood R, Woodruff C, Worthington B, Wynn D, Wysham C, Xavier P, Yela S, Yenoby L, Young L, Younus N, Yourell V, Zaid M, Zubair I., Mann, Jfe, Ørsted, Dd, Brown-Frandsen, K, Marso, Sp, Poulter, Nr, Rasmussen, S, Tornøe, K, Zinman, B, Buse, Jb, Bergenstal R, LEADER Steering Committee and Investigators., Daniels, G, Moses, Ac, Nauck, M, Nissen, S, Pocock, S, Steinberg, W, Stockner, M, Kristensen, P, Ravn, L, Zychma, M, Flyvbjerg, A, Ford, I, Kloos, Rt, Schactman, Mj, Sleight, P, Swedberg, K, Tenner, Sm, Akalın, S, Arechavaleta, R, Bain, S, Babkowski, Mc, Benroubi, M, Berard, L, Comlekci, A, Czupryniak, L, Eliasson, B, Eriksson, M, Fonseca, V, Franek, E, Gross, J, Hafidh, K, Haluzik, M, Hayes, F, Huang, Yy, Jacob, S, Kaddaha, G, Khalil, A, Kilhovd, B, Laakso, M, Leiter, L, Lalic, N, Ji, L, Luedemann, J, Mannucci, E, Marre, M, Masmiquel, L, Mota, M, Omar, M, O’Shea, D, Pan, C, Petrie, J, Pieber, T, Pratley, R, Raz, I, Rea, R, Rutten, G, Satman, I, 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Simons, R, Sinan, A, Singh, M, Sirinvaravong, S, Skero, J, Slover-Zipf, J, Small, S, Smith, B, Smith, K, Smith, M, Sohl, J, Solarz, Sh, Soler, D, Sood, A, Sora, N, Souchet, A, Soule, J, Sparks, J, Spector, L, Speicher, R, Spillers, L, Spivey, T, Springer, N, Sprouse, H, St John, J, Stacey, A, Stacey, H, Stafford, M, Stagner, E, Staples, K, Steadman, E, Steed, R, Steeves, G, Steinberg, H, Stell, C, Stirman, E, Straub, K, Strock, E, Sue, M, Suris, O, Sutton, T, Tabbah, I, Talsania, M, Tang, R, Tapia, J, Taylor, K, Taylor-Hancher, R, Teator, R, Tekateka, M, Temple, B, Temple, K, Teodori, M, Tharp, P, Thethi, T, Theuma, P, Thomas, S, Thottan, A, Thrasher, J, Thrasher, L, Tiemeyer, M, Tinney, I, Tobin, T, Toma, S, Tovar, M, Townsend, J, Trantow, C, Traylor, H, Trevino, M, Troy, M, Trumper, D, Tryggestad, J, Tucker, C, Turner, J, Turney, R, Tuten, C, Tyzack, J, Ullo, L, Underkofler, C, Unger, J, Urdanetta, R, Valdivia, V, Valenti, S, Vanderheiden, A, Vanderlinde-Wood, M, Varma, C, Vasquez, 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- Subjects
Male ,Settore MED/09 - Medicina Interna ,Acute Kidney Injury ,Aged ,Albuminuria ,Creatinine ,Diabetes Mellitus, Type 2 ,Diabetic Nephropathies ,Double-Blind Method ,Female ,Follow-Up Studies ,Glomerular Filtration Rate ,Glucagon-Like Peptide 1 ,Humans ,Hypoglycemic Agents ,Intention to Treat Analysis ,Kidney Failure, Chronic ,Liraglutide ,Middle Aged ,Type 2 diabetes ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,GLOMERULAR-FILTRATION-RATE ,KIDNEY-FUNCTION ,DISEASE ,law.invention ,Kidney Failure ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Medicine ,Settore MED/49 - Scienze Tecniche Dietetiche Applicate ,Chronic ,RISK ,Kidney ,Acute kidney injury ,11 Medical And Health Sciences ,General Medicine ,medicine.anatomical_structure ,TRIAL ,liraglutide, randomized controlled trial, type 2 diabetes, renal outcomes ,Life Sciences & Biomedicine ,Type 2 ,medicine.drug ,medicine.medical_specialty ,Renal function ,030209 endocrinology & metabolism ,CARDIOVASCULAR OUTCOMES ,Follow-Up Studie ,03 medical and health sciences ,Medicine, General & Internal ,General & Internal Medicine ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Intensive care medicine ,Science & Technology ,business.industry ,MORTALITY ,medicine.disease ,INTENSIVE GLUCOSE CONTROL ,INDIVIDUALS ,chemistry ,Diabetic Nephropathie ,LEADER Steering Committee and Investigators ,business - Abstract
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).
- Published
- 2017
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