Search

Unlabelled: Atherosclerosis is a chronic and progressive inflammatory process that causes the most advanced changes in elderly people. In 2006 we published the results of the analysis of acute coronary syndromes in patients after 80 years of age. Conducted the study have decided to extend the observation of distant patients. THE AIM of this study was to assess the effectiveness of remote monitoring percutaneous coronary intervention (PCI) performed in patients with acute coronary syndrome after 80 years of age and to demonstrate the potential benefits of the treatment on the basis of well-being and quality of life of studied patients., Materials and Methods: The study included 15 women and 16 men aged from 80 to 92 years, which in 2005 because of acute coronary syndrome (ACS) PCI was performed with stenting of coronary vessels., Results: The 31-person group of patients after percutaneous coro-: nary intervention to the end of the observation period 24 patients survived, while seven died. A comparison group of patients living with the deceased showed a number of differences, both clinical as well as the biochemical parameters evaluated. Women accounted for up to 72% among the deceased patients. Moreover, increased posthospitalization mortality in patients with ST elevation myocardial infarction was documented. The majority of patients during the observation period was in class II according to the criteria of the Canadian Society of Cardiology., Conclusions: Analysis of the obtained results in the observation of distant percutaneous balloon therapy with stenting of coronary vessels in patients after 80 years of age showed a majority of respondents declared by the benefit of the treatment administered in the form of improved well-being and quality of life. The analysis of deaths during follow-up period showed the increased mortality during posthospitalization period in patients with ST elevation myocardial infarction and documented the predominance of patients with diabetes and other co-morbidities, especially in women.

Unlabelled: Atherosclerosis is a permanently progressive chronic inflammatory disorder which nuclear factor kappaKB (NFkappaB) is involved. Therefore NFkappaB has become integral aspect of atherogenesis and its complications., The Aim of the Study: Estimation of genes expression involved in NFkappaB signaling pathway and separation genes differentiate patients with acute myocardial infarction from healthy subjects., Material and Methods: The examination was assess using the Affymetrix HG-U133A oligonucleotide microarray. Differentiating genes were determined using Bland-Altman graph analysis. Patients wasn't treated due to cardiac diseases before. All patients were subjected to 12-lead ECG, 2-D echocardiography, coronarography and laboratory studies including cardiac troponin, CK and CK-MB. The healthy individuals were subjected to coronarography and computed tomography (calcium score)--coronary artery disease was out of the question., Results: Hierarchical clusterization has demonstrated that the genes expression of patients with acute myocardial infarction was different from healthy individuals. It also demonstrated that the individual groups are homogeneous, especially the group of patients with acute myocardial infarction, regardless of diagnosis, number of risk factors and progression of coronary artery disease. Further Bland-Altman graph analysis showed three important differentiating genes: TLR2, TNFRSF1A i IKBKAP., Conclusions: Our results confirmed the share of genes involved in NFkappaB signaling pathway in acute complications of atherosclerosis. Noticed differences in genes expression of patients with acute myocardial infarction and healthy subjects can show important role isolated differentiating genes in destabilization of atherogenic plaque and acute myocardial infarction occurrence.