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Grid cells play a principal role in enabling mammalian cognitive representations of ambient environments. The key property of these cells -- the regular arrangement of their firing fields -- is commonly viewed as means for establishing spatial scales or encoding specific locations. However, using grid cells' spiking outputs for deducing spatial orderliness proves to be a strenuous task, due to fairly irregular activation patterns triggered by the animal's sporadic visits to the grid fields. The following discussion addresses statistical mechanisms enabling emergent regularity of grid cell firing activity, from the perspective of percolation theory. In particular, it is shown that the range of neurophysiological parameters required for spiking percolation phenomena matches experimental data, which points at biological viability of the percolation approach and casts a new light on the role of grid cells in organizing the hippocampal map., Comment: 15 pages, 5 figures

Topological data analyses are rapidly turning into key tools for quantifying large volumes of neurobiological data, e.g., for organizing the spiking outputs of large neuronal ensembles and thus gaining insights into the information produced by various networks. Below we discuss a case in which several convergent topological analyses not only provide a description of the data structure, but also produce insights into how these data may be processed in the hippocampus---a brain part that plays a key role in learning and memory. The resulting functional model provides a unifying framework for integrating spiking information at different timescales and understanding the course of spatial learning at different levels of spatiotemporal granularity. In particular, the model allows quantifying contributions of various physiological phenomena---brain waves, synaptic strengths, synaptic architectures, etc., into spatial cognition., Comment: 21 page, 4 figures

Spatial awareness in mammals is based on internalized representations of the environment---cognitive maps---encoded by networks of spiking neurons. Although behavioral studies suggest that these maps can remain stable for long periods, it is also well-known that the underlying networks of synaptic connections constantly change their architecture due to various forms of neuronal plasticity. This raises a principal question: how can a dynamic network encode a stable map of space? In the following, we discuss some recent results obtained in this direction using an algebro-topological modeling approach, which demonstrate that emergence of stable cognitive maps produced by networks with transient architectures is not only possible, but may be a generic phenomenon., Comment: 14 pages, 4 figures

The spiking activity of the hippocampal place cells plays a key role in producing and sustaining an internalized representation of the ambient space---a cognitive map. These cells do not only exhibit location-specific spiking during navigation, but also may rapidly replay the navigated routs through endogenous dynamics of the hippocampal network. Physiologically, such reactivations are viewed as manifestations of "memory replays" that help to learn new information and to consolidate previously acquired memories by reinforcing synapses in the parahippocampal networks. Below we propose a computational model of these processes that allows assessing the effect of replays on acquiring a robust topological map of the environment and demonstrate that replays may play a key role in stabilizing the hippocampal representation of space., Comment: 21 pages, 5 figures, 3 supplementary figures

Neuronal activity in the brain generates synchronous oscillations of the Local Field Potential (LFP). The traditional analyses of the LFPs are based on decomposing the signal into simpler components, such as sinusoidal harmonics. However, a common drawback of such methods is that the decomposition primitives are usually presumed from the onset, which may bias our understanding of the signal's structure. Here, we introduce an alternative approach that allows an impartial, high resolution, hands-off decomposition of the brain waves into a small number of discrete, frequency-modulated oscillatory processes, which we call oscillons. In particular, we demonstrate that mouse hippocampal LFP contain a single oscillon that occupies the $\theta$-frequency band and a couple of $\gamma$-oscillons that correspond, respectively, to slow and fast $\gamma$-waves. Since the oscillons were identified empirically, they may represent the actual, physical structure of synchronous oscillations in neuronal ensembles, whereas Fourier-defined "brain waves" are nothing but poorly resolved oscillons., Comment: 17 pages, 9 figures

Hippocampal cognitive map---a neuronal representation of the spatial environment---is broadly discussed in the computational neuroscience literature for decades. More recent studies point out that hippocampus plays a major role in producing yet another cognitive framework that incorporates not only spatial, but also nonspatial memories---the memory space. However, unlike cognitive maps, memory spaces have been barely studied from a theoretical perspective. Here we propose an approach for modeling hippocampal memory spaces as an epiphenomenon of neuronal spiking activity. First, we suggest that the memory space may be viewed as a finite topological space---a hypothesis that allows treating both spatial and nonspatial aspects of hippocampal function on equal footing. We then model the topological properties of the memory space to demonstrate that this concept naturally incorporates the notion of a cognitive map. Lastly, we suggest a formal description of the memory consolidation process and point out a connection between the proposed model of the memory spaces to the so-called Morris' schemas, which emerge as the most compact representation of the memory structure., Comment: 24 pages, 8 Figures, 1 Suppl. Figure

The spiking activity of principal cells in mammalian hippocampus encodes an internalized neuronal representation of the ambient space---a cognitive map. Once learned, such a map enables the animal to navigate a given environment for a long period. However, the neuronal substrate that produces this map remains transient: the synaptic connections in the hippocampus and in the downstream neuronal networks never cease to form and to deteriorate at a rapid rate. How can the brain maintain a robust, reliable representation of space using a network that constantly changes its architecture? Here, we demonstrate, using novel Algebraic Topology techniques, that cognitive map's stability is a generic, emergent phenomenon. The model allows evaluating the effect produced by specific physiological parameters, e.g., the distribution of connections' decay times, on the properties of the cognitive map as a whole. It also points out that spatial memory deterioration caused by weakening or excessive loss of the synaptic connections may be compensated by simulating the neuronal activity. Lastly, the model explicates functional importance of the complementary learning systems for processing spatial information at different levels of spatiotemporal granularity, by establishing three complementary timescales at which spatial information unfolds. Thus, the model provides a principal insight into how can the brain develop a reliable representation of the world, learn and retain memories despite complex plasticity of the underlying networks and allows studying how instabilities and memory deterioration mechanisms may affect learning process., Comment: 24 pages, 10 figures, 4 supplementary figures

While cognitive representations of an environment can last for days and even months, the synaptic architecture of the neuronal networks that underlie these representations constantly changes due to various forms of synaptic and structural plasticity at a much faster timescale. This raises an immediate question: how can a transient network maintain a stable representation of space? In the following, we propose a computational model for describing emergence of the hippocampal cognitive map in a network of transient place cell assemblies and demonstrate, using methods of algebraic topology, that such a network can maintain a robust map of the environment., Comment: 23 pages, 7 figures, 4 suppl. figures

The mammalian hippocampus plays a principal role in producing a cognitive map of space---an internalized representation of the animal's environment. The neuronal mechanisms producing this map depend primarily on the temporal structure of the hippocampal neurons' spiking activity, which is modulated by the oscillatory extracellular electrical field potential. In this paper, we discuss the integrative effect of the gamma rhythm, one of the principal components of these oscillations, on the ability of the place cell ensembles to encode a spatial map. Using methods of algebraic topology and statistical physics, we demonstrate that gamma-modulation of neuronal activity generates a synchronized spiking of dynamical cell assemblies, which enables learning a spatial map at faster timescales., Comment: 14 pages, 4 figures, 7 supplementary figures

Spatial awareness in mammals is based on an internalized representation of the environment, encoded by large networks of spiking neurons. While such representations can last for a long time, the underlying neuronal network is transient: neuronal cells die every day, synaptic connections appear and disappear, the networks constantly change their architecture due to various forms of synaptic and structural plasticity. How can a network with a dynamic architecture encode a stable map of space? We address this question using a physiological model of a "flickering" neuronal network and demonstrate that it can maintain a robust topological representation of space., Comment: 8 pages, 4 figures

Mammalian hippocampus plays a key role in spatial learning and memory, but the exact nature of the hippocampal representation of space is still being explored. Recently, there has been a fair amount of success in modeling hippocampal spatial maps in rats, assuming a topological perspective on spatial information processing. In this paper, we use the topological model to study $3D$ learning in bats, which produces several insights into neurophysiological mechanisms of the hippocampal spatial mapping. First, we demonstrate functional importance of the cell assemblies for producing accurate maps of the $3D$ environments. Second, the model suggests that the readout neurons in these cell assemblies should function as integrators of synaptic inputs, rather than detectors of place cells' coactivity and allows estimating the integration time window. Lastly, the model suggests that, in contrast with relatively slow moving rats, suppressing $\theta$-precession in bats improves the place cells capacity to encode spatial maps, which is consistent with the experimental observations., Comment: 14 pages, 4 figures, 3 supplementary figures

Place cells in the rat hippocampus play a key role in creating the animal's internal representation of the world. During active navigation, these cells spike only in discrete locations, together encoding a map of the environment. Electrophysiological recordings have shown that the animal can revisit this map mentally, during both sleep and awake states, reactivating the place cells that fired during its exploration in the same sequence they were originally activated. Although consistency of place cell activity during active navigation is arguably enforced by sensory and proprioceptive inputs, it remains unclear how a consistent representation of space can be maintained during spontaneous replay. We propose a model that can account for this phenomenon and suggests that a spatially consistent replay requires a number of constraints on the hippocampal network that affect its synaptic architecture and the statistics of synaptic connection strengths., Comment: 15 pages, 5 figures, Neural Computation, 2016