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6. Post-Mortem Imaging

Author

Dabadie, Alexia, Proisy, Maïa, Blondiaux, Eleonore, Piercecchi-Marti, Marie-Dominique, Gorincour, Guillaume, Rey-Salmon, Caroline, editor, and Adamsbaum, Catherine, editor

Published
2018
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10. Appendicitis

Author

Dabadie, Alexia, Petit, Philippe, E. Avni, Fred, editor, and Petit, Philippe, editor

Published
2018
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11. Risk Factors Associated with Traumatic Brain Injury and Implementation of Guidelines for Requesting Computed Tomography After Head Trauma Among Children in France

Author

Roche, Stanislas, primary, Crombé, Amandine, additional, Benhamed, Axel, additional, Hak, Jean-François, additional, Dabadie, Alexia, additional, Fauconnier-Fatus, Clémence, additional, Rega, Adelaïde, additional, Pech-Gourg, Grégoire, additional, Tazarourte, Karim, additional, Seux, Mylène, additional, Acquier, Adrien, additional, and Gorincour, Guillaume, additional

Published
2023
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13. European Pediatric Surgeons' Association Survey on the Use of Splenic Embolization in Blunt Splenic Trauma in Children

Author

Dariel, Anne, additional, Soyer, Tutku, additional, Dingemann, Jens, additional, Pini-Prato, Alessio, additional, Martinez, Leopoldo, additional, Faure, Alice, additional, Oumarou, Mamane, additional, Hassid, Sophie, additional, Dabadie, Alexia, additional, De Coppi, Paolo, additional, Gorter, Ramon, additional, Doi, Tkashi, additional, Antunovic, Sanja Sindjic, additional, Kakar, Mohit, additional, Morini, Francesco, additional, and Hall, Nigel J., additional

Published
2022
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14. Post-Mortem Imaging

Author

Dabadie, Alexia, primary, Proisy, Maïa, additional, Blondiaux, Eleonore, additional, Piercecchi-Marti, Marie-Dominique, additional, and Gorincour, Guillaume, additional

Published
2017
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20. Relevance of Routine Abdominopelvic Ultrasound in Suspected Child Abuse in Children Under 2 years of Age: Review of 15 years of Experience

Author

Martin-Champetier, Antoine, primary, Caujolle, Anaïs, additional, Bosdure, Emmanuelle, additional, Bresson, Violaine, additional, Aschero, Audrey, additional, Desvignes, Catherine, additional, Colavolpe, Nathalie, additional, Pico, Harmony, additional, Seiler, Charlotte, additional, Panuel, Michel, additional, Chaumoitre, Kathia, additional, Petit, Philippe, additional, and Dabadie, Alexia, additional

Published
2021
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22. Ventricular septal defect with anomalous origin of the left descending coronary artery from the right sinus of Valsava and an intraseptal course.

Author

Carles, Guillaume, Peyre, Marianne, Dabadie, Alexia, Macé, Loïc, and Lenoir, Marien

Abstract

Patients with anomalous aortic origin of the left anterior descending coronary artery (AAOCA) from the right sinus of Valsava, and associated with a trans-septal course, are recommended for surgery only when symptoms of ischemia are present. The transconal unroofing method is straightforward and provides good anatomic result. In absence of significant coronary compression, surgical management of the trans-septal coronary course is proposed if the patient is a candidate to cardiac surgery for another reason, such as congenital heart disease. We describe a transconal approach in a patient with a trans-septal coronary artery and a ventricular septal defect. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Relevance of Routine Abdominopelvic Ultrasound in Suspected Child Abuse in Children Under 2 years of Age: Review of 15 years of Experience.

Author

Martin-Champetier, Antoine, Caujolle, Anaïs, Bosdure, Emmanuelle, Bresson, Violaine, Aschero, Audrey, Desvignes, Catherine, Colavolpe, Nathalie, Pico, Harmony, Seiler, Charlotte, Panuel, Michel, Chaumoitre, Kathia, Petit, Philippe, and Dabadie, Alexia

Subjects
ULTRASONIC imaging of the abdomen, PELVIC radiography, ACQUISITION of data methodology, CHILD abuse, RESEARCH methodology, RETROSPECTIVE studies, HUMAN abnormalities, MEDICAL records, COMPUTED tomography, ABDOMINAL injuries, PELVIS, ABDOMINAL radiography, CHILDREN
Abstract

In France, the current recommendation is to perform a routine abdominopelvic ultrasound in any child under 2 years of age who is suspected to have been abused. We retrospectively studied the relevance of this practice in our center over the past fifteen years. This was a descriptive, retrospective study of all children under 2 years of age who had been subject to suspected abuse. Abdominal images and reports were reviewed and cross-referenced with possible clinical and biological signs. Four hundred and five children were included between 2006 and 2020, of whom 296 underwent abdominal imaging (2 initial abdominopelvic CT scans, 4 ultrasounds followed by CT scans, and 290 ultrasounds alone). Four examinations revealed traumatic abnormalities related to abuse. These four children all had clinical or biological anomalies. In the absence of clinical or biological signs, no imagery showed any abnormality related to abuse. [ABSTRACT FROM AUTHOR]

Published
2022
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27. SFCE METRO‐01 four‐drug metronomic regimen phase II trial for pediatric extracranial tumor

Author

Heng-Maillard, Marie-Amélie, Verschuur, Arnauld, Aschero, Audrey, Dabadie, Alexia, Jouve, Elisabeth, Chastagner, Pascal, Leblond, Pierre, Aerts, Isabelle, de Luca, Bénédicte, André, Nicolas, Heng‐maillard, Marie‐amélie, Luca, Bénédicte, Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'Investigation Clinique [Hôpital de la Conception - APHM] (CIC), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Service d'Oncologie Pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Institut Curie [Paris], Aix-Marseille Université - Faculté de pharmacie (AMU PHARM), Aix Marseille Université (AMU), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université Lille Nord de France (COMUE)-UNICANCER

Subjects
Male, [SDV]Life Sciences [q-bio], Gastroenterology, Hemangioendothelioma, extracranial solid tumor, angiogenesis, 0302 clinical medicine, Neoplasms, MESH: Child, metronomic chemotherapy, myoepithelial carcinoma, MESH: Neoplasms, Child, Hematology, pediatric oncology, 3. Good health, Vinblastine, Survival Rate, epithelioid hemangioendothelioma, MESH: Administration, Metronomic, Oncology, 030220 oncology & carcinogenesis, Child, Preschool, Female, Sarcoma, medicine.drug, Adult, medicine.medical_specialty, Adolescent, MESH: Survival Rate, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Neutropenia, Models, Biological, Disease-Free Survival, 03 medical and health sciences, Internal medicine, medicine, Humans, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, MESH: Celecoxib, MESH: Models, Biological, MESH: Adult, medicine.disease, Metronomic Chemotherapy, MESH: Male, Regimen, Celecoxib, Pediatrics, Perinatology and Child Health, Administration, Metronomic, MESH: Disease-Free Survival, Methotrexate, business, MESH: Female, Progressive disease, 030215 immunology
Abstract

Objective To investigate the antitumor activity of a four-drug metronomic chemotherapy (MC) regimen in relapsed/progressing pediatric extracranial solid tumors (EST). The primary objective was clinical benefit (complete response /partial response/stable disease [SD]) after two cycles of therapy (four months). Methods Patients aged ≥4 to 25 years with progressing EST and adequate organ function were eligible. Treatment consisted of an eight-week cycle of oral celecoxib b.i.d., weekly vinblastine, and oral cyclophosphamide for three weeks alternating with oral methotrexate for three weeks, with a two-week rest. The Kepner-Chang two-stage model was used with 10 patients in the first stage. If primary objective was reached in two or more patients, eight additional patients were included according to four groups: neuroblastoma (NBL), soft-tissue sarcoma (STS), bone sarcoma (BS), and miscellaneous (Misc.). Results Forty-four patients were evaluable. The NBL cohort could be expanded to 18 patients: 4 of 18 patients stabilized with MC treatment for 6 (n = 1) and 12 (n = 3) months. In STS, two of seven patients (metastatic hemangioendothelioma and angiosarcoma) had SD for > 2 cycles. One of nine Misc. (metastatic myoepithelial carcinoma) had SD for one year. All patients with BS had progressive disease. One-year progression-free survival of the whole cohort was 6.8% and one-year overall survival was 55.3%. Grade 3 toxicity occurred in 18 patients and grade 4 in 15 patients. The most frequent toxicity was hematologic, predominantly neutropenia. Conclusions This MC has no activity in BS and limited though interesting activity in NBL with some patients being stable for > 1 year. It is not possible to conclude activity in STS and Misc.

Published
2019

28. Liste des contributeurs

Author

Abgral, Ronan, Beregi, Jean-Paul, Bilfeld, Marie Faruch, Huglo, Damien, Le Jeune, Florence, Pontana, François, Tacher, Vania, Bartoli, Jean-Michel, Boutet, Claire, Boyer, Louis, Brunotte, François, Grenier, Nicolas, Petit, Philippe, Prigent, Alain, Salaün, Pierre-Yves, Abihanna, Michel, Adamsbaum, Catherine, Allary, Alexandre, Anxionnat, René, Attyé, Arnaud, Aubé, Christophe, Auber-Lenoir, Manon, Balleyguier, Corinne, Bailly, Clément, Bani-Sadr, Alexandre, Banos, Jean-Bruno, de Bazelaire, Cédric, Bazot, Marc, Beis, Jean-Noël, Bellin, Marie-France, Benoudiba, Farida, Berteloot, Laureline, Bierry, Guillaume, Blondiaux, Éléonore, Bodard, Sylvain, Bodet-Milin, Caroline, Bonardel, Gérald, Bonneville, Fabrice, Boussel, Loïc, Bousson, Valérie, Boussouar, Samia, Bracard, Serge, Braun, Marc, Bricault, Yvan, Brisse, Hervé, Brunelle, Serge, Brunereau, Laurent, Caramella, Caroline, Carpentier, Françoise, Cassagnes, Lucie, Cassart, Marie, Cassinoto, Christophe, Chammas, Agathe, Chassagnon, Guillaume, Chateil, Jean-François, Chaumet-Riffaud, Philippe, Clément, Olivier, Clerc, Jérôme, Combelles, Sophie, Cotten, Anne, Cotton, François, Cuny, Emmanuel, Cyteval, Catherine, Dabadie, Alexia, Dang, Lan-Anh, Daraï, Émile, Darcourt, Jacques, Dechoux-Vodovar, Sophie, Delacourt, Christophe, Demondion, Xavier, Devred, Philippe, Dormont, Didier, Douek, Philippe, Dournes, Gaël, Dousset, Vincent, Dubrulle, Frédérique, Ducou-Le-Pointe, Hubert, Durand, Chantal, Durand, Emmanuel, Duron, Loïc, Edjilali-Goujon, Myriam, Elmaleh, Monique, Ernst, Olivier, Felici, Florence, Ferey, Solène, Ferrié, Jean-Claude, Fleury, Vincent, Fournier, Laure, Gach, Pierre, Galanaud, Damien, Garcier, Jean-Marc, Gauvrit, Jean-Yves, Ghasarossian, Christian, Gocko, Xavier, Gonzalez, Sandra, Gorincour, Guillaume, Grand, Sylvie, Grange, Loïc, Grévent, David, Guéret, Pascal, Hamet, Blandine, Hélénon, Olivier, Héran, Françoise, Hoeffel, Christine, Humbert, Olivier, Imbert, Patrick, Jacquier, Alexis, Kas, Aurélie, Kraeber-Bodéré, Francoise, Krainik, Alexandre, Kuchcinski, Grégory, de Labriolle-Vaylet, Claire, Lainé, Xavier, Laissy, Jean-Pierre, Laurent, François, Lecler, Augustin, Leclerc, Xavier, Le Corroller, Thomas, Lederlin, Mathieu, Legallois, Damien, Leger, Thomas, Lemaître, Laurent, Lenoir, Marion, Le Roux, Pierre-Yves, Leruste, Sébastien, Lignères, Marie, Lucidarme, Olivier, Manrique, Alain, de Margerie-Mellon, Constance, Maugars, Yves, Meder, Jean-François, Merzoug, Valérie, Midulla, Marco, Millet, Ingrid, Montaudon, Michel, Morel, Baptiste, Moulin, Thierry, Naggara, Olivier, Oppenheim, Catherine, Palard, Xavier, Perdrix, Corinne, Pescatori, Lorenzo, Planel, Sophie, Poncelet, Édouard, Proisy, Maia, Pruvo, Jean-Pierre, Puech, Philippe, Pyatigorskaya, Nadya, Querellou-Lefranc, Solène, Renard-Penna, Raphaëlle, Robin, Philippe, Rocher, Laurence, Rodriguez, Christine, Ronot, Maxime, Rousseau, Caroline, Rousset, Jean, Rouvière, Olivier, Rouzet, François, Roy, Catherine, Savoye-Collet, Céline, Simon, Clémentine, Souillard-Scemama, Raphaëlle, Soussan, Michael, Soyer, Philippe, Taourel, Patrice, Tasu, Jean-Pierre, Thomassin-Naggara, Isabelle, Vernet-Kovacsik, Hélène, Vidal, Vincent, Vignes, Jean-Rodolphe, Vija, Lavina, Vuillez, Jean-Philippe, and Wagner, Mathilde

Published
2022
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32. Liste des contributeurs

Author

Abgral, Ronan, Bartoli, Jean-Michel, Boutet, Claire, Darcourt, Jacques, Boyer, Louis, Brunotte, François, Grenier, Nicolas, Petit, Philippe, Prigent, Alain, Salaün, Pierre-Yves, Abihanna, Michel, Adamsbaum, Catherine, Allary, Alexandre, Anxionnat, René, Attyé, Arnaud, Aubé, Christophe, Balleyguier, Corinne, Banos, Jean-Bruno, de Bazelaire, Cédric, Bazot, Marc, Beis, Jean-Noël, Benoudiba, Farida, Bérégi, Jean-Paul, Bierry, Guillaume, Blondiaux, Eléonore, Bodet-Milin, Caroline, Bonardel, Gérald, Bonneville, Fabrice, Boussel, Loïc, Bousson, Valerie, Bracard, Serge, Braun, Marc, Bricault, Yvan, Brisse, Hervé, Cassart, Marie, Carpentier, Françoise, Cassinoto, Christophe, Chateil, Jean-François, Chaumet-Riffaud, Philippe, Clément, Olivier, Clerc, Jérôme, Combelles, Sophie, Cotten, Anne, Cotton, François, Cuny, Emmanuel, Cyteval, Catherine, Dabadie, Alexia, Daraï, Émile, Dechoux-Vodovar, Sophie, de Labriolle-Vaylet, Claire, Delacourt, Christophe, Demondion, Xavier, Devred, Philippe, Dormont, Didier, Douek, Philippe, Dubrulle, Frédérique, Dousset, Vincent, Ducou-le-Pointe, Hubert, Durand, Chantal, Durand, Emmanuel, Duron, Loïc, Elmaleh, Monique, Ernst, Olivier, Felici, Florence, Ferey, Solène, Ferrié, Jean-Claude, Fleury, Vincent, Fournier, Laure, Gach, Pierre, Galanaud, Damien, Garcier, Jean-Marc, Gauvrit, Jean-Yves, Ghasarossian, Christian, Gocko, Xavier, Gonzalez, Sandra, Gorincour, Guillaume, Grand, Sylvie, Grange, Loïc, Grévent, David, Guéret, Pascal, Hélénon, Olivier, Héran, Françoise, Imbert, Patrick, Jacquier, Alexis, Kas, Aurélie, Kraeber-Bodéré, Francoise, Krainik, Alexandre, Kuchcinski, Grégory, Lainé, Xavier, Laissy, Jean-Pierre, Laurent, François, Leclerc, Xavier, Le Corroller, Thomas, Lederlin, Mathieu, Lemaître, Laurent, Legallois, Damien, Lenoir, Marion, Le Roux, Pierre-Yves, Leruste, Sébastien, Lignères, Marie, Lucidarme, Olivier, Manrique, Alain, Maugars, Yves, Meder, Jean-François, Merzoug, Valérie, Millet, Ingrid, Montaudon, Michel, Morel, Baptiste, Moulin, Thierry, Naggara, Olivier, Oppenheim, Catherine, Palard, Xavier, Perdrix, Corinne, Planel, Sophie, Poncelet, Édouard, Proisy, Maia, Pruvo, Jean-Pierre, Querellou-Lefranc, Solène, Renard-Penna, Raphaëlle, Robin, Philippe, Rodriguez, Christine, Ronot, Maxime, Rousseau, Caroline, Rousset, Jean, Rouvière, Olivier, Rouzet, François, Roy, Catherine, Simon, Clémentine, Souillard-Scemama, Raphaëlle, Soussan, Michael, Soyer, Philippe, Tacher, Vania, Taourel, Patrice, Tasu, Jean-Pierre, Thomassin-Naggara, Isabelle, Vernet-Kovacsik, Hélène, Vidal, Vincent, Vignes, Jean-Rodolphe, Vija, Lavina, and Vuillez, Jean-Philippe

Published
2019
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33. Liste des auteurs

Author

Adamsbaum, Catherine, Akkari, Samia, Arama, Emmanuel, Aschero, Audrey, Aubart, Mélodie, Avni, Fred E, Beccaria, Kevin, Bertrand, Margaux, Bessou, Pierre, Blondiaux, Éléonore, Blouet, Marie, Boddaert, Nathalie, Boumerzoug, Meriem, Boutry, Nathalie, Brisse, Hervé, Cardoen, Liesbeth, Chateil, Jean-François, Colavolpe, Nathalie, Dabadie, Alexia, Dangouloff-Ros, Volodia, Delmas, Jean, Desvignes, Catherine, le Pointe, Hubert Ducou, Durand, Chantal, El Fayoumi, Mohamed, Elmaleh-Bergès, Monique, Falip, Céline, Ferey, Solène, Fievet, Adèle, Franchi-Abella, Stéphanie, Garel, Catherine, Grangette, Ève, Grévent, David, Habre, Céline, Hassani, Adnan, Lahoche, Annie, Le Cam, Solène, Lérisson, Héloïse, Levy, Raphaël, Mathiot, Anne, Morel, Baptiste, Nicolas, Nayla, Ouerd, Linda, Petit, Philippe, Pico, Harmony, Priso, Réne-Hilaire, Rapilat, Daniela, Rocher, Laurence, Roux, Charles-Joris, Seiler, Charlotte, Taveau, Catherine Sembély, Suffee, Cécile, Perre, Saskia Vande, Verpillat, Pauline, and Vivier, Pierre-Hugues

Published
2022
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34. Liste des collaborateurs

Author

Auloge, Pierre, Baron-Sarrabère, Marie-Pierre, Bonafé, Alain, Byl, David, Chaumoitre, Kathia, Coget, Arthur, Coze, Stéphanie, Cyteval, Catherine, Dabadie, Alexia, Faget, Claire, Hamard, Aymeric, Heautot, Jean-Francois, Laneelle, Damien, Larbi, Ahmed, Larralde, Antoine, Lederlin, Mathieu, Mahe, Guillaume, Mandoul, Caroline, de Champfleur, Nicolas Menjot, Millet, Ingrid, Mohammad, Hélène, Orliac, Céline, Panuel, Michel, Scemama, Ugo, Stefanovic, Xavier, Taourel, Patrice, Tas, Marine, Thouvenin, Yann, Verheyden, Cécile, and Zins, Marc

Published
2019
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37. SFCE METRO-01 four-drug metronomic regimen phase II trial for pediatric extracranial tumor.

Author

Heng-Maillard MA, Verschuur A, Aschero A, Dabadie A, Jouve E, Chastagner P, Leblond P, Aerts I, De Luca B, and André N

Subjects
Adolescent, Adult, Celecoxib adverse effects, Child, Child, Preschool, Disease-Free Survival, Female, Humans, Male, Neoplasms mortality, Survival Rate, Administration, Metronomic, Celecoxib administration & dosage, Models, Biological, Neoplasms drug therapy
Abstract

Objective: To investigate the antitumor activity of a four-drug metronomic chemotherapy (MC) regimen in relapsed/progressing pediatric extracranial solid tumors (EST). The primary objective was clinical benefit (complete response /partial response/stable disease [SD]) after two cycles of therapy (four months)., Methods: Patients aged ≥4 to 25 years with progressing EST and adequate organ function were eligible. Treatment consisted of an eight-week cycle of oral celecoxib b.i.d., weekly vinblastine, and oral cyclophosphamide for three weeks alternating with oral methotrexate for three weeks, with a two-week rest. The Kepner-Chang two-stage model was used with 10 patients in the first stage. If primary objective was reached in two or more patients, eight additional patients were included according to four groups: neuroblastoma (NBL), soft-tissue sarcoma (STS), bone sarcoma (BS), and miscellaneous (Misc.)., Results: Forty-four patients were evaluable. The NBL cohort could be expanded to 18 patients: 4 of 18 patients stabilized with MC treatment for 6 (n = 1) and 12 (n = 3) months. In STS, two of seven patients (metastatic hemangioendothelioma and angiosarcoma) had SD for > 2 cycles. One of nine Misc. (metastatic myoepithelial carcinoma) had SD for one year. All patients with BS had progressive disease. One-year progression-free survival of the whole cohort was 6.8% and one-year overall survival was 55.3%. Grade 3 toxicity occurred in 18 patients and grade 4 in 15 patients. The most frequent toxicity was hematologic, predominantly neutropenia., Conclusions: This MC has no activity in BS and limited though interesting activity in NBL with some patients being stable for > 1 year. It is not possible to conclude activity in STS and Misc., (© 2019 Wiley Periodicals, Inc.)

Published
2019
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