Search

Your search keyword '"Daans, Jasmijn"' showing total 145 results
Start Over Author "Daans, Jasmijn"
145 results on '"Daans, Jasmijn"'

1. Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease

Author

Kara, Firat, Belloy, Michael E., Voncken, Rick, Sarwari, Zahra, Garima, Yadav, Anckaerts, Cynthia, Langbeen, An, Leysen, Valerie, Shah, Disha, Jacobs, Jules, Hamaide, Julie, Bols, Peter, Van Audekerke, Johan, Daans, Jasmijn, Guglielmetti, Caroline, Kantarci, Kejal, Prevot, Vincent, Roßner, Steffen, Ponsaerts, Peter, Van der Linden, Annemie, and Verhoye, Marleen

Published
2021
Full Text
View/download PDF

2. Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

Author

Quarta, Alessandra, Le Blon, Debbie, D'aes, Tine, Pieters, Zoë, Hamzei Taj, Somayyeh, Miró-Mur, Francesc, Luyckx, Evi, Van Breedam, Elise, Daans, Jasmijn, Goossens, Herman, Dewilde, Sylvia, Hens, Niel, Pasque, Vincent, Planas, Anna M., Hoehn, Mathias, Berneman, Zwi, and Ponsaerts, Peter

Published
2019
Full Text
View/download PDF

4. Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María José, De Laere, Maxime, Lee, Wai-Ping, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, De Reu, Hans, Jolanta Keliris, Aneta, Van Audekerke, Johan, Vanreusel, Verdi, Pieters, Zoë, Van der Linden, Annemie, Verhoye, Marleen, Molenberghs, Geert, Hens, Niel, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Berneman, Zwi N., Martínez-Cáceres, Eva María, and Cools, Nathalie

Published
2019
Full Text
View/download PDF

11. Histological Characterization and Quantification of Cellular Events Following Neural and Fibroblast(-Like) Stem Cell Grafting in Healthy and Demyelinated CNS Tissue

Author

Praet, Jelle, primary, Santermans, Eva, additional, Reekmans, Kristien, additional, de Vocht, Nathalie, additional, Le Blon, Debbie, additional, Hoornaert, Chloé, additional, Daans, Jasmijn, additional, Goossens, Herman, additional, Berneman, Zwi, additional, Hens, Niel, additional, Van der Linden, Annemie, additional, and Ponsaerts, Peter, additional

Published
2014
Full Text
View/download PDF

15. Long‐term deprivation of ovarian hormones via ovariectomy alters functional connectivity, brain neurochemistry and white matter integrity in a mouse model of Alzheimer's disease

Author

Kara, Firat, primary, Belloy, Michael E, additional, Voncken, Rick, additional, Sarwari, Zahra, additional, Yadav, Garima, additional, Anckaerts, Cynthia, additional, Langbeen, An, additional, Leysen, Valérie, additional, Shah, Disha, additional, Jacobs, Jules, additional, Hamaide, Julie, additional, Bols, Peter, additional, Van Audekerke, Johan, additional, Daans, Jasmijn, additional, Guglielmetti, Caroline, additional, Kantarci, Kejal, additional, Prevot, Vincent, additional, Rossner, Steffen, additional, Ponsaerts, Peter, additional, Van Der Linden, Annemie, additional, and Verhoye, Marleen, additional

Published
2020
Full Text
View/download PDF

17. Additional file 2: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Abstract

Figure S2. Graphical overview of the protein structure of murine MOG. (PDF 357 kb)

Published
2019
Full Text
View/download PDF

18. Additional file 6: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
body regions, nervous system, fungi, hemic and immune systems, chemical and pharmacologic phenomena
Abstract

Figure S6. Flow cytometric evaluation of the proportion of Treg, Breg and NK cells in splenocytes. (PDF 289 kb)

Published
2019
Full Text
View/download PDF

19. MOESM2 of Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Author

Ben-Nejma, Inès, Keliris, Aneta, Daans, Jasmijn, Ponsaerts, Peter, Verhoye, Marleen, Linden, Annemie Van Der, and Keliris, Georgios

Abstract

Additional file 2: Figure S2.Time evolution of FC in regions of the DMN network. Each graph shows the FC over time of a specific region. Results are shown as mean ± SEM. Significant [Genotype*Time] interaction and Time effect are indicated with stars and dotted line, respectively. *p

Published
2019
Full Text
View/download PDF

20. Additional file 1: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
body regions, nervous system, fungi, education, psychological phenomena and processes
Abstract

Figure S1. Graphical overview of the culture protocol for murine bone marrow-derived dendritic cells. (PDF 271 kb)

Published
2019
Full Text
View/download PDF

21. Additional file 5: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Abstract

Figure S5. Representation of individual clinical scores. (PDF 349 kb)

Published
2019
Full Text
View/download PDF

22. Additional file 3: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Abstract

Figure S3. Nucleotide sequence of the Sig-full length MOG-LAMP-3 and Sig-extracellular MOG-LAMP-3 constructs. (PDF 385 kb)

Published
2019
Full Text
View/download PDF

23. Additional file 7: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
nervous system, fungi
Abstract

Table S1. Amino acid sequences of the myelin peptides used for screening for inter- and intramolecular epitope spreading. (PDF 317 kb)

Published
2019
Full Text
View/download PDF

24. Additional file 4: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Figure S4. Graphical overview of the experimental set-up of the in vivo experiment. (PDF 279 kb)

Published
2019
Full Text
View/download PDF

25. Additional file 8: of Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María, Laere, Maxime De, Wai-Ping Lee, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, Reu, Hans De, Keliris, Aneta Jolanta, Audekerke, Johan Van, Vanreusel, Verdi, Pieters, Zoë, Linden, Annemie Van Der, Verhoye, Marleen, Molenberghs, Geert, Niel Hens, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Zwi Berneman, Martínez-Cáceres, Eva, and Cools, Nathalie

Subjects
body regions, nervous system, immune system diseases, fungi, nervous system diseases
Abstract

Table S2. Clinical data of MOG35–55 EAE mice. (PDF 393 kb)

Published
2019
Full Text
View/download PDF

27. Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice

Author

Ibrahimi Abdelilah, Daans Jasmijn, Reekmans Kristien, Verschueren Jacob, Tambuyzer Bart, De Vocht Nathalie, Bergwerf Irene, Van Tendeloo Viggo, Chatterjee Shyama, Goossens Herman, Jorens Philippe G, Baekelandt Veerle, Ysebaert Dirk, Van Marck Eric, Berneman Zwi N, Linden Annemie, and Ponsaerts Peter

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract Background Cell transplantation is likely to become an important therapeutic tool for the treatment of various traumatic and ischemic injuries to the central nervous system (CNS). However, in many pre-clinical cell therapy studies, reporter gene-assisted imaging of cellular implants in the CNS and potential reporter gene and/or cell-based immunogenicity, still remain challenging research topics. Results In this study, we performed cell implantation experiments in the CNS of immunocompetent mice using autologous (syngeneic) luciferase-expressing bone marrow-derived stromal cells (BMSC-Luc) cultured from ROSA26-L-S-L-Luciferase transgenic mice, and BMSC-Luc genetically modified using a lentivirus encoding the enhanced green fluorescence protein (eGFP) and the puromycin resistance gene (Pac) (BMSC-Luc/eGFP/Pac). Both reporter gene-modified BMSC populations displayed high engraftment capacity in the CNS of immunocompetent mice, despite potential immunogenicity of introduced reporter proteins, as demonstrated by real-time bioluminescence imaging (BLI) and histological analysis at different time-points post-implantation. In contrast, both BMSC-Luc and BMSC-Luc/eGFP/Pac did not survive upon intramuscular cell implantation, as demonstrated by real-time BLI at different time-points post-implantation. In addition, ELISPOT analysis demonstrated the induction of IFN-γ-producing CD8+ T-cells upon intramuscular cell implantation, but not upon intracerebral cell implantation, indicating that BMSC-Luc and BMSC-Luc/eGFP/Pac are immune-tolerated in the CNS. However, in our experimental transplantation model, results also indicated that reporter gene-specific immune-reactive T-cell responses were not the main contributors to the immunological rejection of BMSC-Luc or BMSC-Luc/eGFP/Pac upon intramuscular cell implantation. Conclusion We here demonstrate that reporter gene-modified BMSC derived from ROSA26-L-S-L-Luciferase transgenic mice are immune-tolerated upon implantation in the CNS of syngeneic immunocompetent mice, providing a research model for studying survival and localisation of autologous BMSC implants in the CNS by real-time BLI and/or histological analysis in the absence of immunosuppressive therapy.

Published
2009
Full Text
View/download PDF

28. Plasmid-based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene expression after transplantation in rat spinal cord

Author

Van Tendeloo Viggo FI, D'Haese Patrick, Vermeulen Katrien, Chatterjee Shyama, Spaepen Gie, Daans Jasmijn, Ronsyn Mark W, Van Marck Eric, Ysebaert Dirk, Berneman Zwi N, Jorens Philippe G, and Ponsaerts Peter

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract Background Bone marrow-derived stromal cells (MSC) are attractive targets for ex vivo cell and gene therapy. In this context, we investigated the feasibility of a plasmid-based strategy for genetic modification of human (h)MSC with enhanced green fluorescent protein (EGFP) and neurotrophin (NT)3. Three genetically modified hMSC lines (EGFP, NT3, NT3-EGFP) were established and used to study cell survival and transgene expression following transplantation in rat spinal cord. Results First, we demonstrate long-term survival of transplanted hMSC-EGFP cells in rat spinal cord under, but not without, appropriate immune suppression. Next, we examined the stability of EGFP or NT3 transgene expression following transplantation of hMSC-EGFP, hMSC-NT3 and hMSC-NT3-EGFP in rat spinal cord. While in vivo EGFP mRNA and protein expression by transplanted hMSC-EGFP cells was readily detectable at different time points post-transplantation, in vivo NT3 mRNA expression by hMSC-NT3 cells and in vivo EGFP protein expression by hMSC-NT3-EGFP cells was, respectively, undetectable or declined rapidly between day 1 and 7 post-transplantation. Further investigation revealed that the observed in vivo decline of EGFP protein expression by hMSC-NT3-EGFP cells: (i) was associated with a decrease in transgenic NT3-EGFP mRNA expression as suggested following laser capture micro-dissection analysis of hMSC-NT3-EGFP cell transplants at day 1 and day 7 post-transplantation, (ii) did not occur when hMSC-NT3-EGFP cells were transplanted subcutaneously, and (iii) was reversed upon re-establishment of hMSC-NT3-EGFP cell cultures at 2 weeks post-transplantation. Finally, because we observed a slowly progressing tumour growth following transplantation of all our hMSC cell transplants, we here demonstrate that omitting immune suppressive therapy is sufficient to prevent further tumour growth and to eradicate malignant xenogeneic cell transplants. Conclusion In this study, we demonstrate that genetically modified hMSC lines can survive in healthy rat spinal cord over at least 3 weeks by using adequate immune suppression and can serve as vehicles for transgene expression. However, before genetically modified hMSC can potentially be used in a clinical setting to treat spinal cord injuries, more research on standardisation of hMSC culture and genetic modification needs to be done in order to prevent tumour formation and transgene silencing in vivo.

Published
2007
Full Text
View/download PDF

30. Immune remodelling of stromal cell grafts in the central nervous system : therapeutic inflammation or (harmless) side-effect?

Author

Le Blon, Debbie, Hoornaert, Chloé, Detrez, Jan, Bevers, Sanne, Daans, Jasmijn, Goossens, Herman, De Vos, Winnok, Berneman, Zwi Nisan, and Ponsaerts, Peter

Subjects
Human medicine, Biology, Engineering sciences. Technology
Abstract

Over the past two decades, several cell types with fibroblast-like morphology, including mesenchymal stem/stromal cells, but also other adult, embryonic and extra-embryonic fibroblast-like cells, have been brought forward in the search for cellular therapies to treat severe brain injuries and/or diseases. Although current views in regenerative medicine are highly focused on the immune modulating and regenerative properties of stromal cell transplantation in vivo, many open questions remain regarding their true mode of action. In this perspective, this study integrates insights gathered over the past 10 years to formulate a unifying model of the cellular events that accompany fibroblast-like cell grafting in the rodent brain. Cellular interactions are discussed step-by-step, starting from the day of implantation up to 10 days after transplantation. During the short period that precedes stable settlement of autologous/syngeneic stromal cell grafts, there is a complex interplay between hypoxia-mediated cell death of grafted cells, neutrophil invasion, microglia and macrophage recruitment, astrocyte activation and neo-angiogenesis within the stromal cell graft site. Consequently, it is speculated that regenerative processes following cell therapeutic intervention in the CNS are not only modulated by soluble factors secreted by grafted stromal cells (bystander hypothesis), but also by in vivo inflammatory processes following stromal cell grafting. Copyright © 2016 John Wiley & Sons, Ltd.

Published
2017

31. Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Author

Guglielmetti, Caroline, Le Blon, Debbie, Santermans, Eva, Salas-Perdomo, Angelica, Daans, Jasmijn, De Vocht, Nathalie, Shah, Disha, Hoornaert, Chloé, Praet, Jelle, Peerlings, Jurgen, Kara, Firat, Bigot, Christian, Mai, Zhenhua, Hens, Niels, Hendrix, Sven, Verhoye, Marleen, Planas, Anna M, Berneman, Zwi, Van der Linden, Annemie, and Ponsaerts, Peter

Subjects
magnetic resonance imaging, demyelination, multiple sclerosis
Abstract

Detrimental inflammatory responses in the central nervous system are a hallmark of various brain injuries and diseases. With this study we provide evidence that lentiviral vector-mediated expression of the immune-modulating cytokine interleukin 13 (IL-13) induces an alternative activation program in both microglia and macrophages conferring protection against severe oligodendrocyte loss and demyelination in the cuprizone mouse model for multiple sclerosis (MS). First, IL-13 mediated modulation of cuprizone induced lesions was monitored using T2-weighted magnetic resonance imaging and magnetization transfer imaging, and further correlated with quantitative histological analyses for inflammatory cell influx, oligodendrocyte death, and demyelination. Second, following IL-13 immune gene therapy in cuprizone-treated eGFP+ bone marrow chimeric mice, we provide evidence that IL-13 directs the polarization of both brain-resident microglia and infiltrating macrophages towards an alternatively activated phenotype, thereby promoting the conversion of a pro-inflammatory environment toward an anti-inflammatory environment, as further evidenced by gene expression analyses. Finally, we show that IL-13 immune gene therapy is also able to limit lesion severity in a pre-existing inflammatory environment. In conclusion, these results highlight the potential of IL-13 to modulate microglia/macrophage responses and to improve disease outcome in a mouse model for MS.

Published
2016
Full Text
View/download PDF

33. In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants

Author

Hoornaert, Chloé C.J., Verbeeck, Louca, Quarta, Alessandra, De Vocht, Nathalie, Lemmens, Evi, Goossens, Herman, van der linden, Annemie, Roobrouck, Valerie V.D., Verfaillie, Catherine, Hendrix, Sven, Moser, Muriel, Luyckx, Evi, Berneman, Zwi Nisan, Ponsaerts, Peter, Reekmans, Kristien, Dhainaut, Maxime, Guglielmetti, Caroline, Le Blon, Debbie, Dooley, Dearbhaile, Fransen, Erik, Daans, Jasmijn, Hoornaert, Chloé C.J., Verbeeck, Louca, Quarta, Alessandra, De Vocht, Nathalie, Lemmens, Evi, Goossens, Herman, van der linden, Annemie, Roobrouck, Valerie V.D., Verfaillie, Catherine, Hendrix, Sven, Moser, Muriel, Luyckx, Evi, Berneman, Zwi Nisan, Ponsaerts, Peter, Reekmans, Kristien, Dhainaut, Maxime, Guglielmetti, Caroline, Le Blon, Debbie, Dooley, Dearbhaile, Fransen, Erik, and Daans, Jasmijn

Abstract

Transplantation of mesenchymal stem cells (MSCs) into injured or diseased tissue—for the in situ delivery of a wide variety of MSC-secreted therapeutic proteins—is an emerging approach for the modulation of the clinical course of several diseases and traumata. From an emergency point-of-view, allogeneic MSCs have numerous advantages over patient-specific autologous MSCs since “off-the-shelf” cell preparations could be readily available for instant therapeutic intervention following acute injury. Although we confirmed the in vitro immunomodulatory capacity of allogeneic MSCs on antigen-presenting cells with standard coculture experiments, allogeneic MSC grafts were irrevocably rejected by the host's immune system upon either intramuscular or intracerebral transplantation. In an attempt to modulate MSC allograft rejection in vivo, we transduced MSCs with an interleukin-13 (IL13)-expressing lentiviral vector. Our data clearly indicate that prolonged survival of IL13-expressing allogeneic MSC grafts in muscle tissue coincided with the induction of an alternatively activated macrophage phenotype in vivo and a reduced number of alloantigen-reactive IFNγ- and/or IL2-producing CD8+ T cells compared to nonmodified allografts. Similarly, intracerebral IL13-expressing MSC allografts also exhibited prolonged survival and induction of an alternatively activated macrophage phenotype, although a peripheral T cell component was absent. In summary, this study demonstrates that both innate and adaptive immune responses are effectively modulated in vivo by locally secreted IL13, ultimately resulting in prolonged MSC allograft survival in both muscle and brain tissue. Stem Cells 2016;34:1971–1984., SCOPUS: ar.j, FLWOA, info:eu-repo/semantics/published

Published
2016

34. Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Author

Le Blon, Debbie, primary, Guglielmetti, Caroline, additional, Hoornaert, Chloé, additional, Quarta, Alessandra, additional, Daans, Jasmijn, additional, Dooley, Dearbhaile, additional, Lemmens, Evi, additional, Praet, Jelle, additional, De Vocht, Nathalie, additional, Reekmans, Kristien, additional, Santermans, Eva, additional, Hens, Niel, additional, Goossens, Herman, additional, Verhoye, Marleen, additional, Van der Linden, Annemie, additional, Berneman, Zwi, additional, Hendrix, Sven, additional, and Ponsaerts, Peter, additional

Published
2016
Full Text
View/download PDF

35. Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Author

Guglielmetti, Caroline, primary, Le Blon, Debbie, additional, Santermans, Eva, additional, Salas-Perdomo, Angelica, additional, Daans, Jasmijn, additional, De Vocht, Nathalie, additional, Shah, Disha, additional, Hoornaert, Chloé, additional, Praet, Jelle, additional, Peerlings, Jurgen, additional, Kara, Firat, additional, Bigot, Christian, additional, Mai, Zhenhua, additional, Goossens, Herman, additional, Hens, Niel, additional, Hendrix, Sven, additional, Verhoye, Marleen, additional, Planas, Anna M., additional, Berneman, Zwi, additional, van der Linden, Annemie, additional, and Ponsaerts, Peter, additional

Published
2016
Full Text
View/download PDF

37. In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants

Author

Hoornaert, Chloé J., primary, Luyckx, Evi, additional, Reekmans, Kristien, additional, Dhainaut, Maxime, additional, Guglielmetti, Caroline, additional, Le Blon, Debbie, additional, Dooley, Dearbhaile, additional, Fransen, Erik, additional, Daans, Jasmijn, additional, Verbeeck, Louca, additional, Quarta, Alessandra, additional, De Vocht, Nathalie, additional, Lemmens, Evi, additional, Goossens, Herman, additional, Van der Linden, Annemie, additional, Roobrouck, Valerie D., additional, Verfaillie, Catherine, additional, Hendrix, Sven, additional, Moser, Muriel, additional, Berneman, Zwi N., additional, and Ponsaerts, Peter, additional

Published
2016
Full Text
View/download PDF

39. Early Inflammatory Responses following Cell Grafting in the CNS Trigger Activation of the Subventricular Zone: A Proposed Model of Sequential Cellular Events

Author

Praet, Jelle, primary, Santermans, Eva, additional, Daans, Jasmijn, additional, Le Blon, Debbie, additional, Hoornaert, Chloé, additional, Goossens, Herman, additional, Hens, Niel, additional, Van Der Linden, Annemie, additional, Berneman, Zwi, additional, and Ponsaerts, Peter, additional

Published
2015
Full Text
View/download PDF

40. Cuprizone‐induced demyelination and demyelination‐associated inflammation result in different proton magnetic resonance metabolite spectra

Author

Praet, Jelle, primary, Orije, Jasmien, additional, Kara, Firat, additional, Guglielmetti, Caroline, additional, Santermans, Eva, additional, Daans, Jasmijn, additional, Hens, Niel, additional, Verhoye, Marleen, additional, Berneman, Zwi, additional, Ponsaerts, Peter, additional, and Van der Linden, Annemie, additional

Published
2015
Full Text
View/download PDF

41. Distinct In Vitro Properties of Embryonic and Extraembryonic Fibroblast-Like Cells are Reflected in their in Vivo Behavior following Grafting in the Adult Mouse Brain

Author

Costa, Roberta, primary, Bergwerf, Irene, additional, Santermans, Eva, additional, De Vocht, Nathalie, additional, Praet, Jelle, additional, Daans, Jasmijn, additional, Le Blon, Debbie, additional, Hoornaert, Chloé, additional, Reekmans, Kristien, additional, Hens, Niel, additional, Goossens, Herman, additional, Berneman, Zwi, additional, Parolini, Ornella, additional, Alviano, Francesco, additional, and Ponsaerts, Peter, additional

Published
2015
Full Text
View/download PDF

45. Cell Type-Associated Differences in Migration, Survival, and Immunogenicity following Grafting in CNS Tissue

Author

Praet, Jelle, primary, Reekmans, Kristien, additional, Lin, Dan, additional, De Vocht, Nathalie, additional, Bergwerf, Irene, additional, Tambuyzer, Bart, additional, Daans, Jasmijn, additional, Hens, Niel, additional, Goossens, Herman, additional, Pauwels, Patrick, additional, Berneman, Zwi, additional, Van Der Linden, Annemie, additional, and Ponsaerts, Peter, additional

Published
2012
Full Text
View/download PDF

47. Clinical Potential of Intravenous Neural Stem Cell Delivery for Treatment of Neuroinflammatory Disease in Mice?

Author

Reekmans, Kristien P., primary, Praet, Jelle, additional, De Vocht, Nathalie, additional, Tambuyzer, Bart R., additional, Bergwerf, Irene, additional, Daans, Jasmijn, additional, Baekelandt, Veerle, additional, Vanhoutte, Greetje, additional, Goossens, Herman, additional, Jorens, Philippe G., additional, Ysebaert, Dirk K., additional, Chatterjee, Shyama, additional, Pauwels, Patrick, additional, Van Marck, Eric, additional, Berneman, Zwi N., additional, Van Der Linden, Annemie, additional, and Ponsaerts, Peter, additional

Published
2011
Full Text
View/download PDF

49. Recognition of cellular implants by the brain's innate immune system

Author

Bergwerf, Irene, primary, Tambuyzer, Bart, additional, De Vocht, Nathalie, additional, Reekmans, Kristien, additional, Praet, Jelle, additional, Daans, Jasmijn, additional, Chatterjee, Shyama, additional, Pauwels, Patrick, additional, Linden, Annemie, additional, Berneman, Zwi N, additional, and Ponsaerts, Peter, additional

Published
2010
Full Text
View/download PDF

50. Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice

Author

Bergwerf, Irene, primary, De Vocht, Nathalie, additional, Tambuyzer, Bart, additional, Verschueren, Jacob, additional, Reekmans, Kristien, additional, Daans, Jasmijn, additional, Ibrahimi, Abdelilah, additional, Van Tendeloo, Viggo, additional, Chatterjee, Shyama, additional, Goossens, Herman, additional, Jorens, Philippe G, additional, Baekelandt, Veerle, additional, Ysebaert, Dirk, additional, Van Marck, Eric, additional, Berneman, Zwi N, additional, Linden, Annemie Van Der, additional, and Ponsaerts, Peter, additional

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results