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1. A personalized model and optimization strategy for estimating blood glucose concentrations from sweat measurements

Author

Yin, Xiaoyu, Peri, Elisabetta, Pelssers, Eduard, Toonder, Jaap den, Klous, Lisa, Daanen, Hein, and Mischi, Massimo

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Background and objective: Diabetes is one of the four leading causes of death worldwide, necessitating daily blood glucose monitoring. While sweat offers a promising non-invasive alternative for glucose monitoring, its application remains limited due to the low to moderate correlation between sweat and blood glucose concentrations, which has been obtained until now by assuming a linear relationship. This study proposes a novel model-based strategy to estimate blood glucose concentrations from sweat samples, setting the stage for non-invasive glucose monitoring through sweat-sensing technology. Methods: We first developed a pharmacokinetic glucose transport model that describes the glucose transport from blood to sweat. Secondly, we designed a novel optimization strategy leveraging the proposed model to solve the inverse problem and infer blood glucose levels from measured glucose concentrations in sweat. To this end, the pharmacokinetic model parameters with the highest sensitivity were also optimized so as to achieve a personalized estimation. Our strategy was tested on a dataset composed of 108 samples from healthy volunteers and diabetic patients. Results: Our glucose transport model improves over the state-of-the-art in estimating sweat glucose concentrations from blood levels (higher accuracy, p<0.001). Additionally, our optimization strategy effectively solved the inverse problem, yielding a Pearson correlation coefficient of 0.98 across all 108 data points, with an average root-mean-square-percent-error of 12%+/-8%. This significantly outperforms the best sweat-blood glucose correlation reported in the existing literature (0.75). Conclusion: Our innovative optimization strategy, also leveraging more accurate modeling, shows promising results, paving the way for non-invasive blood glucose monitoring and, possibly, improved diabetes management.

Published
2024

8. Evaluating assumptions of scales for subjective assessment of thermal environments – Do laypersons perceive them the way, we researchers believe?

Author

Schweiker, Marcel, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea Risky, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha Yacob, Azar, Elie, Bannazadeh, Bahareh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti Aisyah, Daniel, Lyrian, De Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi Prabha, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla Ghaffari, Harimi, Djamila, Hellwig, Runa T, Huebner, Gesche M, Jin, Quan, Jowkar, Mina, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M Donny, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, MC Jeffrey, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, Mino-Rodriguez, Isabel, Montazami, Azadeh, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, de Abreu, Ana Lígia Papst, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph F, Rivera, Ma Isabel, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Suhendri, Suhendri, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu B, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, ZahraSadat

Subjects
Thermal comfort, Thermal sensation, Thermal acceptance, Field study, Scales, Post-Occupancy-Evaluation: Climatic zone, Season, Language, Adaptation, Diversity, Engineering, Built Environment and Design, Building & Construction
Abstract

People's subjective response to any thermal environment is commonly investigated by using rating scales describing the degree of thermal sensation, comfort, and acceptability. Subsequent analyses of results collected in this way rely on the assumption that specific distances between verbal anchors placed on the scale exist and that relationships between verbal anchors from different dimensions that are assessed (e.g. thermal sensation and comfort) do not change. Another inherent assumption is that such scales are independent of the context in which they are used (climate zone, season, etc.). Despite their use worldwide, there is indication that contextual differences influence the way the scales are perceived and therefore question the reliability of the scales’ interpretation. To address this issue, a large international collaborative questionnaire study was conducted in 26 countries, using 21 different languages, which led to a dataset of 8225 questionnaires. Results, analysed by means of robust statistical techniques, revealed that only a subset of the responses are in accordance with the mentioned assumptions. Significant differences appeared between groups of participants in their perception of the scales, both in relation to distances of the anchors and relationships between scales. It was also found that respondents’ interpretations of scales changed with contextual factors, such as climate, season, and language. These findings highlight the need to carefully consider context-dependent factors in interpreting and reporting results from thermal comfort studies or post-occupancy evaluations, as well as to revisit the use of rating scales and the analysis methods used in thermal comfort studies to improve their reliability.

Published
2020

9. Publisher Correction: The Scales Project, a cross-national dataset on the interpretation of thermal perception scales.

Author

Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti, Daniel, Lyrian, Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla, Harimi, Djamila, Hellwig, Runa, Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph, Rivera, Ma, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

11. The Scales Project, a cross-national dataset on the interpretation of thermal perception scales.

Author

Schweiker, Marcel, Abdul-Zahra, Amar, André, Maíra, Al-Atrash, Farah, Al-Khatri, Hanan, Alprianti, Rea, Alsaad, Hayder, Amin, Rucha, Ampatzi, Eleni, Arsano, Alpha, Azadeh, Montazami, Azar, Elie, Bahareh, Bannazadeh, Batagarawa, Amina, Becker, Susanne, Buonocore, Carolina, Cao, Bin, Choi, Joon-Ho, Chun, Chungyoon, Daanen, Hein, Damiati, Siti, Daniel, Lyrian, Vecchi, Renata, Dhaka, Shivraj, Domínguez-Amarillo, Samuel, Dudkiewicz, Edyta, Edappilly, Lakshmi, Fernández-Agüera, Jesica, Folkerts, Mireille, Frijns, Arjan, Gaona, Gabriel, Garg, Vishal, Gauthier, Stephanie, Jabbari, Shahla, Harimi, Djamila, Hellwig, Runa, Huebner, Gesche, Jin, Quan, Jowkar, Mina, Kania, Renate, Kim, Jungsoo, King, Nelson, Kingma, Boris, Koerniawan, M, Kolarik, Jakub, Kumar, Shailendra, Kwok, Alison, Lamberts, Roberto, Laska, Marta, Lee, M, Lee, Yoonhee, Lindermayr, Vanessa, Mahaki, Mohammadbagher, Marcel-Okafor, Udochukwu, Marín-Restrepo, Laura, Marquardsen, Anna, Martellotta, Francesco, Mathur, Jyotirmay, McGill, Gráinne, Mino-Rodriguez, Isabel, Mou, Di, Moujalled, Bassam, Nakajima, Mia, Ng, Edward, Okafor, Marcellinus, Olweny, Mark, Ouyang, Wanlu, Papst de Abreu, Ana, Pérez-Fargallo, Alexis, Rajapaksha, Indrika, Ramos, Greici, Rashid, Saif, Reinhart, Christoph, Rivera, Ma, Salmanzadeh, Mazyar, Schakib-Ekbatan, Karin, Schiavon, Stefano, Shooshtarian, Salman, Shukuya, Masanori, Soebarto, Veronica, Tahsildoost, Mohammad, Tartarini, Federico, Teli, Despoina, Tewari, Priyam, Thapa, Samar, Trebilcock, Maureen, Trojan, Jörg, Tukur, Ruqayyatu, Voelker, Conrad, Yam, Yeung, Yang, Liu, Zapata-Lancaster, Gabriela, Zhai, Yongchao, Zhu, Yingxin, and Zomorodian, Zahra

Abstract

Thermal discomfort is one of the main triggers for occupants interactions with components of the built environment such as adjustments of thermostats and/or opening windows and strongly related to the energy use in buildings. Understanding causes for thermal (dis-)comfort is crucial for design and operation of any type of building. The assessment of human thermal perception through rating scales, for example in post-occupancy studies, has been applied for several decades; however, long-existing assumptions related to these rating scales had been questioned by several researchers. The aim of this study was to gain deeper knowledge on contextual influences on the interpretation of thermal perception scales and their verbal anchors by survey participants. A questionnaire was designed and consequently applied in 21 language versions. These surveys were conducted in 57 cities in 30 countries resulting in a dataset containing responses from 8225 participants. The database offers potential for further analysis in the areas of building design and operation, psycho-physical relationships between human perception and the built environment, and linguistic analyses.

Published
2019

13. Practical application of a heuristic model for swim coaches to optimize training.

Author

Ganzevles, Sander, Beek, Peter Jan, Daanen, Hein, and Truijens, Martin

Subjects
SWIMMING coaches, SWIMMING coaching, SWIMMING training, ATHLETE training, HEART beat
Abstract

Swim coaches routinely monitor the performance and performance determining variables of their athletes to optimize training programs in an individual-specific manner with the ultimate aim to swim faster and win races. To interpret the collected data, they require a suitable, and practically useful, conceptual framework, which can be found in the power balance of swimming. For coaches a heuristic model for training and performance optimization based on the power balance has been proposed. We build on this model and illustrate how it can be employed in the training practice using data of an exemplary sub-elite swimmer (700 FINA points), which was collected continuously during two training sessions. Variables that are used in daily swim training practice, such as heart rate (HR), stroke count (SC), stroke rate (SR), and lap time (LT), were measured. By combining external load variables (e.g. LT) and internal load variables (e.g. HR) with technical variables (e.g. SR), the degree to which the swimmer complies with the training program can be determined. The measured values of these variables are presented using a traffic light feedback system indicating the degree of compliance. The traffic light system enables coaches to adjust the program if deemed necessary. It is thus shown how the model and commonly measured variables can assist swim coaches in the design and evaluation of training sessions in their pursuit of personal performance improvement leading to greater athletic success. [ABSTRACT FROM AUTHOR]

Published
2024
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16. COVID-19 and heat waves: New challenges for healthcare systems

Author

Bose-O’Reilly, Stephan, Daanen, Hein, Deering, Katharina, Gerrett, Nicola, Huynen, Maud Maria Theresia Elisabeth, Lee, Jason, Karrasch, Stefan, Matthies-Wiesler, Franziska, Mertes, Hanna, Schoierer, Julia, Shumake-Guillemot, Joy, van den Hazel, Peter, Frank van Loenhout, Joris Adriaan, and Nowak, Dennis

Published
2021
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18. Heat Acclimation

Author

Racinais, Sébastien, Sawka, Michael, Daanen, Hein, Périard, Julien D., Périard, Julien D., editor, and Racinais, Sébastien, editor

Published
2019
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20. Body Core Temperature Assessment in Emergency Care Departments

Author

Daanen, Hein A.M., primary, Hoitinga, Gercora, additional, Kruijt, David J., additional, Koning, Kevin S., additional, Verheijen, Pooh P., additional, de Baas, Sanne I.M., additional, Bergsma, Anouk R., additional, Snethlage, Cathelijne E., additional, Al-Bander, Iman, additional, and Teunissen, Lennart P.J., additional

Published
2024
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24. Response

Author

Alkemade, Puck, primary, Daanen, Hein A. M., additional, Janssen, Thomas W. J., additional, and Eijsvogels, Thijs M. H., additional

Published
2023
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28. Upper-Body versus Lower-Body Cooling in Individuals with Paraplegia during Arm-Crank Exercise in the Heat

Author

Alkemade, Puck (author), Eijsvogels, Thijs M.H. (author), Janssen, Thomas W.J. (author), Jansen, K.M.B. (author), Kingma, Boris R.M. (author), Daanen, Hein A.M. (author), Alkemade, Puck (author), Eijsvogels, Thijs M.H. (author), Janssen, Thomas W.J. (author), Jansen, K.M.B. (author), Kingma, Boris R.M. (author), and Daanen, Hein A.M. (author)

Abstract

PURPOSE: For wheelchair users with a spinal cord injury, the lower body may be a more convenient cooling site than the upper body. However, it remains unknown if leg cooling reduces thermal strain in these individuals. We compared the impact of upper-body versus lower-body cooling on physiological and perceptual outcomes during submaximal arm-crank exercise under heat stress in individuals with paraplegia. METHODS: Twelve male participants with paraplegia (T4-L2, 50% complete lesion) performed a maximal exercise test in temperate conditions, and three heat stress tests (32°C, 40% relative humidity) in which they received upper-body cooling (COOL-UB), lower-body cooling (COOL-LB), or no cooling (CON) in a randomized counterbalanced order. Each heat stress test consisted of four exercise blocks of 15 min at 50% of peak power output, with 3 min of rest in between. Cooling was applied using water-perfused pads, with 14.8-m tubing in both COOL-UB and COOL-LB. RESULTS: Gastrointestinal temperature was 0.2°C (95% confidence interval (CI), 0.1°C to 0.3°C) lower during exercise in COOL-UB versus CON (37.5°C ± 0.4°C vs 37.7°C ± 0.3°C, P = 0.009), with no difference between COOL-LB and CON ( P = 1.0). Heart rate was lower in both COOL-UB (-7 bpm; 95% CI, -11 to -3 bpm; P = 0.01) and COOL-LB (-5 bpm; 95% CI, -9 to -1 bpm; P = 0.049) compared with CON. The skin temperature reduction at the cooled skin sites was larger in COOL-LB (-10.8°C ± 1.1°C) than in COOL-UB (-6.7°C ± 1.4°C, P < 0.001), which limited the cooling capacity in COOL-LB. Thermal sensation of the cooled skin sites was improved and overall thermal discomfort was lower in COOL-UB ( P = 0.01 and P = 0.04) but not in COOL-LB ( P = 0.17 and P = 0.59) compared with CON. CONCLUSIONS: Upper-body cooling more effectively reduced thermal strain than lower-body cooling in individuals with paraplegia, as it induced greater thermophysiological and perceptual benefits., Emerging Materials

Published
2023
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32. List of contributors

Author

Daanen, Hein A.M., primary, Dulgheriu, Ionuț, additional, Früh, Hans-Christian, additional, Goyal, Ashvani, additional, Gries, Thomas, additional, Ionescu, Irina, additional, Jana, Prabir, additional, Jhanji, Yamini, additional, Klingele, Josef, additional, Loghin, Emil-Constantin, additional, Loghin, Maria-Carmen, additional, Lutz, Volker, additional, Machova, Katerina, additional, Nayak, Rajkishore, additional, Niebel, Volker, additional, Nijhar, Kanwalpreet, additional, Padhye, Rajiv, additional, Patnaik, Asis, additional, Patnaik, Sweta, additional, Psikuta, Agnes, additional, Saggiomo, Marco, additional, Simonis, Kristina, additional, Singh, Amanpreet, additional, Vilumsone-Nemes, Ineta, additional, and Wischnowski, Marko, additional

Published
2018
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43. Sex differences in temperature-related all-cause mortality in the Netherlands

Author

Economics of Global Environmental Change, UU LEG Research UUSE Multidisciplinary Economics, Folkerts, Mireille A., Bröde, Peter, Botzen, W. J.Wouter, Martinius, Mike L., Gerrett, Nicola, Harmsen, Carel N., Daanen, Hein A.M., Economics of Global Environmental Change, UU LEG Research UUSE Multidisciplinary Economics, Folkerts, Mireille A., Bröde, Peter, Botzen, W. J.Wouter, Martinius, Mike L., Gerrett, Nicola, Harmsen, Carel N., and Daanen, Hein A.M.

Published
2022

45. Heat preparedness and exertional heat illness in Paralympic athletes: A Tokyo 2020 survey.

Author

Alkemade, Puck, Daanen, Hein A. M., Janssen, Thomas W. J., Broad, Elizabeth, Goosey-Tolfrey, Victoria L., Ibusuki, Tatsuru, Kneepkens, Hiske, Périard, Julien D., and Eijsvogels, Thijs M. H.

Subjects
*ATHLETES with disabilities, *PREPAREDNESS, *ACCLIMATIZATION, *INTERNET surveys, *DIZZINESS
Abstract

Paralympic athletes may be at increased risk for exertional heat illness (EHI) due to reduced thermoregulatory ability as a consequence of their impairment. This study investigated the occurrence of heat-stress related symptoms and EHI, and the use of heat mitigation strategies in Paralympic athletes, both in relation to the Tokyo 2020 Paralympic Games and previous events. Paralympic athletes competing in Tokyo 2020 were invited to complete an online survey five weeks prior to the Paralympics and up to eight weeks after the Games. 107 athletes (30 [24–38] years, 52% female, 20 nationalities, 21 sports) completed the survey. 57% of respondents had previously experienced heat-stress related symptoms, while 9% had been medically diagnosed with EHI. In Tokyo, 21% experienced at least one heat-stress related symptom, while none reported an EHI. The most common symptom and EHI were, respectively, dizziness and dehydration. In preparation for Tokyo, 58% of respondents used a heat acclimation strategy, most commonly heat acclimatization, which was more than in preparation for previous events (45%; P = 0.007). Cooling strategies were used by 77% of athletes in Tokyo, compared to 66% during past events (P = 0.18). Cold towels and packs were used most commonly. Respondents reported no medically-diagnosed EHIs during the Tokyo 2020 Paralympic Games, despite the hot and humid conditions in the first seven days of competition. Heat acclimation and cooling strategies were used by the majority of athletes, with heat acclimation being adopted more often than for previous competitions. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Differences in swimming smoothness between elite and non-elite swimmers.

Author

Ganzevles, Sander P. M., Beek, Peter J., Daanen, Hein A. M., Coolen, Bart M. A., and Truijens, Martin J.

Subjects
MOTION, MULTIPLE regression analysis, TIME, ACCELEROMETERS, MOVEMENT disorders, PHYSIOLOGICAL effects of acceleration, ACCELEROMETRY, COMPARATIVE studies, SCAPULA, DESCRIPTIVE statistics, RESEARCH funding, SWIMMING, ATHLETIC ability
Abstract

The aim of the study was to investigate whether jerk cost (JC) can discriminate between swimming levels. Nine elite and nine non-elite swimmers swam a 50-m front-crawl sprint wearing a 3D accelerometer on their back between the inferior angles of the scapulae. Lap times and JC were calculated from the acceleration signal and compared between groups and between swimmers within a group. The elite swimmers swam significantly faster lap times than the non-elite swimmers (p < 0.001). They did so with significantly lower levels of JC compared to the non-elite swimmers (p = 0.005). Furthermore, a stepwise multiple linear regression showed JC accounted for 32.9% of the variation in lap time of the elite swimmers. These results indicate that it is possible to discriminate elite from non-elite swimmers using JC: elite swimmers swim with lower JCs than non-elite swimmers. Additionally, swimming at higher speed is associated with more accelerations and decelerations in both elite and non-elite swimmers, which is reflected by higher JCs and lower smoothness. In sum, JC provides an index of swimming technique that is easy to use in training practice. [ABSTRACT FROM AUTHOR]

Published
2023
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